DOCSLIB.ORG

Literature Review Zero Alcohol Red Wine

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Literature Review Zero Alcohol Red Wine A 1876 LI A A U R S T T S R U A L A I A FLAVOURS, FRAGRANCES AND INGREDIENTS 6 1 7 8 7 8 1 6 A I B A L U A S R T B Essential Oils, Botanical Extracts, Cold Pressed Oils, BOTANICAL Infused Oils, Powders, Flours, Fermentations INNOVATIONS LITERATURE REVIEW HEALTH BENEFITS RED WINE ZERO ALCOHOL RED WINE RED WINE EXTRACT POWDER www.botanicalinnovations.com.au EXECUTIVE SUMMARY The term FRENCH PARADOX is used to describe the relatively low incidence of cardiovascular disease in the French population despite the high consumption of red wine. Over the past 27 years numerous clinical studies have found a linkages with the ANTIOXIDANTS in particular, the POLYPHENOLS, RESVERATROL, CATECHINS, QUERCERTIN and ANTHOCYANDINS in red wine and reduced incidences of cardiovascular disease. However, the alcohol in wine limits the benefits of wine. Studies have shown that zero alcohol red wine and red wine extract which contain the same ANTIOXIDANTS including POLYPHENOLS, RESVERATROL, CATECHINS, QUERCERTIN and ANTHOCYANDINS has the same is not more positive health benefits. The following literature review details some of the most recent positive health benefits derived from the ANTIOXIDANTS found in red wine POLYPHENOLS: RESVERATROL, CATECHINS, QUERCERTIN and ANTHOCYANDINS. The positive polyphenolic antioxidant effects of the polyphenols in red wine include: • Cardio Vascular Health Benefits • Increase antioxidants in the cardiovascular system • Assisting blood glucose control • Skin health • Bone Health • Memory • Liking blood and brain health • Benefits for the Central nervous system • Neuro cognitive health • Maintenance of a good hormonal balance • Bone density (osteoporosis) • Joint health (osteoarthritis) • Muscle function (sarcopenia) • Skin health using oral supplements and topical applications • Blood homeostasis imbalance • Cognitive performance • Quality of life (vitality, mood, perception of pain) Botanical Innovations Literature Review Nutraceutical Health Benefits Zero Alcohol Wine Powder 1 A 1876 LI A A U R S T T S R U A A L I A 6 1 7 8 8 7 1 6 A I B L A A U R S RED WINE T B EXTRACT POWDER BOTANICAL INNOVATIONS BOTANICAL INNOVATIONS RED WINE EXTRACT POWDER IS A RICH SOURCE OF ANTIOXIDANTS in particular, the POLYPHENOLS, RESVERATROL, CATECHINS, QUERCETIN and ANTHOCYANDINS. These polyphenols found in red wine are linked to reduced incidences of cardiovascular disease. However, the alcohol in wine limits the benefits of wine. Studies have shown that zero alcohol red wine and red wine extract which contain the same ANTIOXIDANTS including POLYPHENOLS, RESVERATROL, CATECHINS, QUERCERTIN and ANTHOCYANDINS has the same is not more positive health benefits. The Botanical Innovations literature review details some of the most recent positive health benefits derived from the ANTIOXIDANTS found in red wine POLYPHENOLS: RESVERATROL,CATECHINS, QUERCETIN and ANTHOCYANDINS. The positive polyphenolic antioxidant effects of the polyphenols in red wine include: • Cardio Vascular Health Benefits • Increase antioxidants in the cardiovascular system • Assisting blood glucose control • Skin health • Bone Health • Memory • Liking blood and brain health • Benefits for the Central nervous system • Neuro cognitive health • Maintenance of a good hormonal balance • Bone density (osteoporosis) • Joint health (osteoarthritis) • Muscle function (sarcopenia) • Skin health using oral supplements and topical applications • Blood homeostasis imbalance • Cognitive performance • Quality of life (vitality, mood, perception of pain) BOTANICAL INNOVATIONS GROUP [email protected] Tel: +61488196527 www.botanicalinnovations.com.au A 1876 LI A A U R S T T S R U A A L I A 6 FLAVOURS, FRAGRANCES AND INGREDIENTS 1 7 8 8 7 1 6 A I B L A A U R S T B Essential Oils, Botanical Extracts, Cold Pressed Oils, BOTANICAL Infused Oils, Powders, Flours, Fermentations INNOVATIONS ZERO ALCOHOL WINE POWDER Functional Wine Flavoured Powders made from Australian Wine A unique range of wine powders which retain the flavour of the wine they were made from without the alcohol. These powders are made from wine. These powders are not low alcohol substitutes. Wine powders are made from wine that has undergone a traditional oenology (wine making) process that is vinification of wine, starting with the selection of the fruit, its fermentation into alcohol, finishing and bottling. The raw material is good wine. The alcohol is then gently removed via proprietary technology and dried to ensure the flavour and aroma of the wine remain. ZERO ALCOHOL WINE WITH DEPTH, FLAVOUR AND AROMA OF WINE. Shiraz Powder Sparkling Brut Powder Pinot Noir Powder Chardonnay Powder Cabinet Sauvignon Powder Reisling Powder Tawny Port Powder Savignon Blanc Powder Aroma The aroma of the wine they were made from. Zero Alcohol All the alcohol is removed during the drying process Taste The taste of a good wine. Functionality Add flavour, aroma and depth to food and beverages without the alcohol. Nutraceutical Benefits Botanical Innovations wine powders contain natural polyphenols. The wine powders capture the proanthocyanidins and resveratrol in wine without the alcohol. T: +61488196527 E: [email protected] BotanicalInnovations.com.au A 1876 LI A A U R S T T S R U A A L I A 6 FLAVOURS, FRAGRANCES AND INGREDIENTS 1 7 8 8 7 1 6 A I B L A A U R S T B Essential Oils, Botanical Extracts, Cold Pressed Oils, BOTANICAL Infused Oils, Powders, Flours, Fermentations INNOVATIONS BOTANICAL INNOVATIONS A 1876 LI A A U R S T T S R A U L A I A 1 6 8 7 7 8 6 1 A B I A L U A S R T B Botanical Innovations is an Australian Bio Technology which has developed a range of unique AUSTRALIAN NUTRACEUTICAL FLAVOURS, FRAGRANCES and INGREDIENTS for functional foods and beverages, natural healthcare and cosmeceutical applications. The company invests heavily in research and development with its innovations featured in the Australian Food and Agribusiness Book published by the Food Innovations Australia limited 2017, 2018 and 2019. Botanical Innovations properietary products Apple Sweetener, Apple Cider Vinegar Powder and Zero Alcohol WinePowders Food and Beverage Innovative Ingredient Awards winner 2017 and 2018 and finalist 2019 respectively. The Botanical Innovations product range includes phytonutrient rich Plant Extracts, Cold Pressed Seed Oils, Oil Infusions, Fermentations and Essential Oils. By unlocking natures secrets Botanical Innovations has created new classes of flavours, fragrances and ingredients that contain phenolic rich phyto nutrients the natural chemical compounds produced by plants from photosynthesis. Botanical Innovations database of scientific literature provides our customers with access to the latest research and applications for our unique range of products. BotanicalInnovations.com.au Table of Contents EXECUTIVE SUMMARY ..................................................................................................... 1 ABSTRACTS ...................................................................................................................... 3 Wine as a biological fluid: history, production, and role in disease prevention. ........ 3 Effects of de-alcoholated red wine and its phenolic fractions on platelet aggregation........................................................................................................................... 4 Red wine phenolic complexes and their in vitro antioxidant activity. .......................... 5 Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox"................................................................................................................. 6 Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels. .................................................................................................................................... 8 Cardioprotection of red wine: role of polyphenolic antioxidants. ............................... 10 ARTICLES ........................................................................................................................11 The Immune Protective Effect of the Mediterranean Diet against Chronic Low-grade Inflammatory Diseases ...................................................................................................... 11 Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits ........ 11 Resveratrol and Its Effects on the Vascular System ..................................................... 11 Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies ................................................................................................................................ 11 Resveratrol, a natural chemoprevenative agent against degrenerative diseases..... 11 Wine and Cardiovascular Health A Comprehensive Review ........................................ 11 Red wine: A drink to your heart ....................................................................................... 11 Botanical Innovations Literature Review Nutraceutical Health Benefits Zero Alcohol Wine Powder 2 ABSTRACTS Wine as a biological fluid: history, production, and role in disease prevention. Soleas GJ1, Diamandis EP, Goldberg DM. J Clin Lab Anal. 1997;11(5):287-313. Wine has been part of human culture for 6,000 years, serving dietary and socio- religious functions. Its production takes place on every continent, and
Load more

Recommended publications
  • Anti-Inflammatory Effects of Resveratrol and Related Polyphenols Contribute to Their Potential Beneficial Effects in Aging
    Tavener SK, et al., J Food Sci Nutr 2020, 6: 079 DOI: 10.24966/FSN-1076/100079 HSOA Journal of Food Science and Nutrition Review Article Abbreviations Anti-Inflammatory Effects BDNF: Brain-derived neurotrophic factor C5: Complement 5 of Resveratrol and Related CCL2: Chemokine (C-C motif) ligand 2 (aka MCP-1) Polyphenols Contribute to their CD: Cluster of differentiation COX-2: Cyclooxygenase-2 Potential Beneficial Effects in CRP: C-reactive protein CXCL10: C-X-C motif chemokine 10 Aging FOXO: Forkhead transcription factor GM-CSF: Granulocyte-macrophage colony-stimulating factor Selena K Tavener and Kiran S Panickar* HSP70: Heat shock protein 70 Science & Technology Center, Hill’s Pet Nutrition Center, Topeka, Kansas, ICAM-1: Intercellular adhesion molecule 1 USA IFN-γ: Interferon-gamma iNOS: Inducible nitric oxide synthase IL-6: Interleukin-6 Abstract JAK/STAT: Janus kinase/Signal transducer and activator of Resveratrol is a polyphenol found in grapes, blueberries, mulberry transcription and raspberry. Due to its antioxidant, anti-inflammatory, anti-microbial JNK: c-Jun N-terminal kinase and anti-proliferative properties resveratrol has been reported to LPS: Lipopolysaccharide have health benefits in aging and age-related health disorders. While MAPK: Mitogen-activated protein kinase the actions of resveratrol and related polyphenols are likely multi- MCP-1: Monocyte chemoattractant protein -1 factorial, the anti-inflammatory of polyphenols are reasonably well documented. Most studies demonstrating efficacy with resveratrol MIP-α: Macrophage inflammatory protein-1 alpha have been conducted in animal models or in vitro models. In human miR: microRNA trials some promising effects of resveratrol have been reported for NAD: Nicotinamide adenine dinucleotide several health conditions including cancer, dementia, inflammatory NFκB: Nuclear factor kappa B bowel syndrome, arthritis, ulcer and dermatological disorders.
    [Show full text]
  • Stilbenes: Chemistry and Pharmacological Properties
    1 Journal of Applied Pharmaceutical Research 2015, 3(4): 01-07 JOURNAL OF APPLIED PHARMACEUTICAL RESEARCH ISSN No. 2348 – 0335 www.japtronline.com STILBENES: CHEMISTRY AND PHARMACOLOGICAL PROPERTIES Chetana Roat*, Meenu Saraf Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India Article Information ABSTRACT: Medicinal plants are the most important source of life saving drugs for the Received: 21st September 2015 majority of the Worlds’ population. The compounds which synthesized in the plant from the Revised: 15th October 2015 secondary metabolisms are called secondary metabolites; exhibit a wide array of biological and Accepted: 29th October 2015 pharmacological properties. Stilbenes a small class of polyphenols, have recently gained the focus of a number of studies in medicine, chemistry as well as have emerged as promising Keywords molecules that potentially affect human health. Stilbenes are relatively simple compounds Stilbene; Chemistry; synthesized by plants and deriving from the phenyalanine/ polymalonate route, the last and key Structures; Biosynthesis pathway; enzyme of this pathway being stilbene synthase. Here, we review the biological significance of Pharmacological properties stilbenes in plants together with their biosynthesis pathway, its chemistry and its pharmacological significances. INTRODUCTION quantities are present in white and rosé wines, i.e. about a tenth Plants are source of several drugs of natural origin and hence of those of red wines. Among these phenolic compounds, are termed as the medicinal plants. These drugs are various trans-resveratrol, belonging to the stilbene family, is a major types of secondary metabolites produced by plants; several of active ingredient which can prevent or slow the progression of them are very important drugs.
    [Show full text]
  • Wo 2009/118338 A3
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 1 October 2009 (01.10.2009) WO 2009/118338 A3 (51) International Patent Classification: CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, A61K 31/085 (2006.01) A61K 31/7004 (2006.01) EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 31/09 (2006.01) A61K 31/7048 (2006.01) HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, A61K 31/353 (2006.01) A61P 25/28 (2006.01) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, (21) International Application Number: NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, PCT/EP2009/0535 19 SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, (22) International Filing Date: UG, US, UZ, VC, VN, ZA, ZM, ZW. 25 March 2009 (25.03.2009) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (26) Publication Language: English ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, (30) Priority Data: TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, 08300163.6 27 March 2008 (27.03.2008) EP ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR), (71) Applicant (for all designated States except US): IN- OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, SERM (Institut National de Ia Sante et de Ia Recherche MR, NE, SN, TD, TG).
    [Show full text]
  • Rational Design of Resveratrol O-Methyltransferase for the Production of Pinostilbene
    International Journal of Molecular Sciences Article Rational Design of Resveratrol O-methyltransferase for the Production of Pinostilbene Daniela P. Herrera 1 , Andrea M. Chánique 1,2 , Ascensión Martínez-Márquez 3, Roque Bru-Martínez 3 , Robert Kourist 2 , Loreto P. Parra 4,* and Andreas Schüller 4,5,* 1 Department of Chemical and Bioprocesses Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile; [email protected] (D.P.H.); [email protected] (A.M.C.) 2 Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria; [email protected] 3 Department of Agrochemistry and Biochemistry, Faculty of Science and Multidisciplinary Institute for Environmental Studies “Ramon Margalef”, University of Alicante, 03690 Alicante, Spain; [email protected] (A.M.-M.); [email protected] (R.B.-M.) 4 Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile 5 Department of Molecular Genetics and Microbiology, School of Biological Sciences, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O’Higgins 340, Santiago 8320000, Chile * Correspondence: [email protected] (L.P.P.); [email protected] (A.S.) Abstract: Pinostilbene is a monomethyl ether analog of the well-known nutraceutical resveratrol. Both compounds have health-promoting properties, but the latter undergoes rapid metabolization and has low bioavailability. O-methylation improves the stability and bioavailability of resveratrol. In plants, these reactions are performed by O-methyltransferases (OMTs). Few efficient OMTs that Citation: Herrera, D.P.; Chánique, monomethylate resveratrol to yield pinostilbene have been described so far.
    [Show full text]
  • Plant Phenolics: Bioavailability As a Key Determinant of Their Potential Health-Promoting Applications
    antioxidants Review Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications Patricia Cosme , Ana B. Rodríguez, Javier Espino * and María Garrido * Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain; [email protected] (P.C.); [email protected] (A.B.R.) * Correspondence: [email protected] (J.E.); [email protected] (M.G.); Tel.: +34-92-428-9796 (J.E. & M.G.) Received: 22 October 2020; Accepted: 7 December 2020; Published: 12 December 2020 Abstract: Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic compounds has dramatically increased during the last decade due to their biological effects and promising therapeutic applications. In this review, we discuss the importance of phenolic compounds’ bioavailability to accomplish their physiological functions, and highlight main factors affecting such parameter throughout metabolism of phenolics, from absorption to excretion. Besides, we give an updated overview of the health benefits of phenolic compounds, which are mainly linked to both their direct (e.g., free-radical scavenging ability) and indirect (e.g., by stimulating activity of antioxidant enzymes) antioxidant properties. Such antioxidant actions reportedly help them to prevent chronic and oxidative stress-related disorders such as cancer, cardiovascular and neurodegenerative diseases, among others. Last, we comment on development of cutting-edge delivery systems intended to improve bioavailability and enhance stability of phenolic compounds in the human body. Keywords: antioxidant activity; bioavailability; flavonoids; health benefits; phenolic compounds 1. Introduction Phenolic compounds are secondary metabolites widely spread throughout the plant kingdom with around 8000 different phenolic structures [1].
    [Show full text]
  • Desoxyrhapontigenin Inhibits RANKL‑Induced Osteoclast Formation and Prevents Inflammation‑Mediated Bone Loss
    INTERNATIONAL JOURNAL OF MOleCular meDICine 42: 569-578, 2018 Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss PHUONG THAO TRAN1, DONG-HWA PARK2, OKHWA KIM1, SEUNG-HAE KWON3, BYUNG-SUN MIN2 and JEONG-HYUNG LEE1 1Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-Do 24341; 2College of Pharmacy, Catholic University of Daegu, Hayang, Gyeongbuk 38430; 3Division of Bio-Imaging, Korea Basic Science Institute Chuncheon Center, Chuncheon, Gangwon-Do 24341, Republic of Korea Received November 6, 2017; Accepted March 15, 2018 DOI: 10.3892/ijmm.2018.3627 Abstract. Desoxyrhapontigenin (DRG), a stilbene compound mouse model. At the molecular level, DRG inhibited the from Rheum undulatum, has been found to exhibit various RANKL-induced activation of extracellular signal-regulated pharmacological activities, however, its impact on osteoclast kinase, the expression of c-Fos, and the induction of NFATc1, formation has not been investigated. The present study inves- a crucial transcription factor for osteoclast formation. DRG tigated the effect of DRG on receptor activator of nuclear decreased the expression levels of osteoclast marker genes, factor-κB ligand (RANKL)-induced osteoclast differen- including matrix metalloproteinase-9, tartrate-resistant acid tiation in mouse bone marrow macrophages (BMMs) and phosphatase and cathepsin K. In conclusion, these findings inflammation‑induced bone loss in vivo. BMMs or RAW264.7 suggested that DRG inhibited the differentiation of BMMs cells were treated with DRG, followed by an evaluation of into mature osteoclasts by suppressing the RANKL-induced cell viability, RANKL-induced osteoclast differentiation, activator protein-1 and NFATc1 signaling pathways, and actin-ring formation and resorption pits activity.
    [Show full text]
  • Optimization of Bioactive Polyphenols Extraction from Picea Mariana Bark
    molecules Article Optimization of Bioactive Polyphenols Extraction from Picea Mariana Bark Nellie Francezon 1,2, Naamwin-So-Bâwfu Romaric Meda 1,2 and Tatjana Stevanovic 1,2,* 1 Renewable Materials Research Centre, Department of Wood and Forest Sciences, Université Laval, Québec, QC G1V 0A6, Canada; [email protected] (N.F.); [email protected] (N.-S.-B.R.M.) 2 Institute of Nutrition and Functional Food (INAF), Université Laval, Quebec, QC G1V 0A6, Canada * Correspondence: [email protected]; Tel.: +1-418-656-2131 Received: 30 October 2017; Accepted: 30 November 2017; Published: 1 December 2017 Abstract: Reported for its antioxidant, anti-inflammatory and non-toxicity properties, the hot water extract of Picea mariana bark was demonstrated to contain highly valuable bioactive polyphenols. In order to improve the recovery of these molecules, an optimization of the extraction was performed using water. Several extraction parameters were tested and extracts obtained analyzed both in terms of relative amounts of different phytochemical families and of individual molecules concentrations. As a result, low temperature (80 ◦C) and low ratio of bark/water (50 mg/mL) were determined to be the best parameters for an efficient polyphenol extraction and that especially for low molecular mass polyphenols. These were identified as stilbene monomers and derivatives, mainly stilbene glucoside isorhapontin (up to 12.0% of the dry extract), astringin (up to 4.6%), resveratrol (up to 0.3%), isorhapontigenin (up to 3.7%) and resveratrol glucoside piceid (up to 3.1%) which is here reported for the first time for Picea mariana. New stilbene derivatives, piceasides O and P were also characterized herein as new isorhapontin dimers.
    [Show full text]
  • List of Compounds 2018 年12 月
    List of Compounds 2018 年12 月 長良サイエンス株式会社 Nagara Science Co., Ltd. 〒501-1121 岐阜市古市場 840 840 Furuichiba, Gifu 501-1121, JAPAN Phone : +81-58-234-4257、Fax : +81-58-234-4724 E-mail : [email protected] 、http : //www.nsgifu.jp Storage Product Name・Purity・Molecular Formula＝Molecular Weight・〔 CAS Quantity Source Code No. C o n di t i o n s Registry Number 〕 ・Price ( JPY ) NH020102 2－10 ℃ (-)-Epicatechin [ (-)-EC ] ≧99% (HPLC) 10mg 8,000 NH020103 C15H14O6 = 290.27 〔490-46-0〕 100mg 44,000 NH020202 2－10 ℃ (-)-Epigallocatechin [ (-)-EGC ] ≧99% (HPLC) 10mg 12,000 NH020203 C15H14O7 = 306.27 〔970-74-1〕 100mg 66,000 NH020302 2－10 ℃ (-)-Epicatechin gallate [ (-)-ECg ] ≧99% (HPLC) 10mg 12,000 NH020303 C22H18O10 = 442.37 〔1257-08-5〕 100mg 52,000 NH020403 2－10 ℃ (-)-Epigallocatechin gallate [ (-)-EGCg ] ≧98% (HPLC) 100mg 12,000 〔 〕 C22H18O11 = 458.37 989-51-5 NH020602 2－10 ℃ (-)-Epigallocatechin gallate [ (-)-EGCg ] ≧99% (HPLC) 20mg 12,000 NH020603 C22H18O11 = 458.37 〔989-51-5〕 100mg 30,000 NH020502 2－10 ℃ (+)-Catechin hydrate [ (+)-C ] ≧99% (HPLC) 10mg 5,000 NH020503 C15H14O6 ･H2O = 308.28 〔88191-48-4〕 100mg 32,000 NH021102 2－10 ℃ (-)-Catechin [ (-)-C ] ≧98% (HPLC) 10mg 23,000 C15H14O6 = 290.27 〔18829-70-4〕 NH021202 2－10 ℃ (-)-Gallocatechin [ (-)-GC ] ≧98% (HPLC) 10mg 34,000 〔 〕 C15H14O7 = 306.27 3371-27-5 NH021302 － ℃ ≧ 10mg 34,000 2 10 (-)-Catechin gallate [ (-)-Cg ] 98% (HPLC) C22H18O10 = 442.37 〔130405-40-2〕 NH021402 2－10 ℃ (-)-Gallocatechin gallate [ (-)-GCg ] ≧98% (HPLC) 10mg 23,000 C22H18O11 = 458.37 〔4233-96-9〕 NH021502 2－10 ℃ (+)-Epicatechin [ (+)-EC
    [Show full text]
  • Systematic Review of Herbals As Potential Anti-Inflammatory Agents
    PHCOG REV. REVIEW ARTICLE Systematic review of herbals as potential anti-infl ammatory agents: Recent advances, current clinical status and future perspectives Sarwar Beg, Suryakanta Swain1, Hameed Hasan2, M Abul Barkat2, Md Sarfaraz Hussain3 Department of Pharamaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 1Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Orissa, 2Department of Pharmacognosy, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, 3Department of Pharmacognosy, Faculty of Pharmacy, Integral University, Khursi Road, Lucknow, India Submitted: 31-08-2010 Revised: 14-02-2011 Published: 23-12-2011 ABSTRACT Many synthetic drugs reported to be used for the treatment of infl ammatory disorders are of least interest now a days due to their potential side effects and serious adverse effects and as they are found to be highly unsafe for human assistance. Since the last few decades, herbal drugs have regained their popularity in treatment against several human ailments. Herbals containing anti-infl ammatory activity (AIA) are topics of immense interest due to the absence of several problems in them, which are associated with synthetic preparations. The primary objective of this review is to provide a deep overview of the recently explored anti-infl ammatory agents belonging to various classes of phytoconstituents like alkaloids, glycosides, terpenoids, steroids, polyphenolic compounds, and also the compounds isolated from plants of marine origin, algae and fungi. Also, it enlists a distended view on potential interactions between herbals and synthetic preparations, related adverse effects and clinical trials done on herbals for exploring their AIA. The basic aim of this review is to give updated knowledge regarding plants which will be valuable for the scientists working in the fi eld of anti-infl ammatory natural chemistry.
    [Show full text]
  • Bioconversion of Stilbenes in Genetically Engineered Root and Cell
    www.nature.com/scientificreports OPEN Bioconversion of stilbenes in genetically engineered root and cell cultures of tobacco Received: 04 November 2016 Diego Hidalgo1, Ascensión Martínez-Márquez2, Elisabeth Moyano3, Roque Bru-Martínez2, Accepted: 20 February 2017 Purificación Corchete4 & Javier Palazon1 Published: 27 March 2017 It is currently possible to transfer a biosynthetic pathway from a plant to another organism. This system has been exploited to transfer the metabolic richness of certain plant species to other plants or even to more simple metabolic organisms such as yeast or bacteria for the production of high added value plant compounds. Another application is to bioconvert substrates into scarcer or biologically more interesting compounds, such as piceatannol and pterostilbene. These two resveratrol-derived stilbenes, which have very promising pharmacological activities, are found in plants only in small amounts. By transferring the human cytochrome P450 hydroxylase 1B1 (HsCYP1B1) gene to tobacco hairy roots and cell cultures, we developed a system able to bioconvert exogenous t-resveratrol into piceatannol in quantities near to mg L−1. Similarly, after heterologous expression of resveratrol O-methyltransferase from Vitis vinifera (VvROMT) in tobacco hairy roots, the exogenous t-resveratrol was bioconverted into pterostilbene. We also observed that both bioconversions can take place in tobacco wild type hairy roots (pRiA4, without any transgene), showing that unspecific tobacco P450 hydroxylases and methyltransferases can perform the bioconversion of t-resveratrol to give the target compounds, albeit at a lower rate than transgenic roots. Trans-resveratrol (t-R) (3,4′ ,5-trihydroxystilbene) is a phytoalexin available from a wide range of dietary sources, including mulberries, peanuts, grapes and wine.
    [Show full text]
  • Applications of Mass Spectrometry in Natural Product Drug Discovery for Malaria: Targeting Plasmodium Falciparum Thioredoxin Reductase
    Applications of mass spectrometry in natural product drug discovery for malaria: Targeting Plasmodium falciparum thioredoxin reductase by Ranjith K. Munigunti A dissertation submitted to the Graduate Faculty of Auburn University in partial fulfillment of the requirements for the Degree of Doctor of Philosophy Auburn, Alabama May 5, 2013 Keywords: Chromatography, mass spectrometry, malaria, Plasmodium falciparum, thioredoxin reductase, thioredoxin Copyright 2013 by Ranjith K. Munigunti Approved by Angela I. Calderón, Chair, Assistant Professor of Pharmacal Sciences C. Randall Clark, Professor of Pharmacal Sciences Jack DeRuiter, Professor of Pharmacal Sciences Forrest Smith, Associate Professor of Pharmacal Sciences Orlando Acevedo, Associate Professor of Chemistry and Biochemistry Abstract Malaria is considered to be the dominant cause of death in low income countries especially in Africa. Malaria caused by Plasmodium falciparum is a most lethal form of the disease because of its rapid spread and the development of drug resistance. The main problem in the treatment of malaria is the emergence of drug resistant malaria parasites. Over the years/decades, natural products have been used for the treatment or prevention of number of diseases. They can serve as compounds of interest both in their natural form and as templates for synthetic modification. Nature has provided a wide variety of compounds that inspired the development of potential therapeutics such as quinine, artemisinin and lapachol as antimalarial agents. As the resistance to known antimalarials is increasing, there is a need to expand the antimalarial drug discovery efforts for new classes of molecules to combat malaria. This research work focuses on the applications of ultrafiltration, mass spectrometry and molecular modeling based approaches to identify inhibitors of Plasmodium falciparum thioredoxin reductase (PfTrxR), our main target and Plasmodium falciparum glutathione reductase (PfGR) as an alternative target for malaria drug discovery.
    [Show full text]
  • Oxyresveratrol의 기원, 생합성, 생물학적 활성 및 약물동력학
    KOREAN J. FOOD SCI. TECHNOL. Vol. 47, No. 5, pp. 545~555 (2015) http://dx.doi.org/10.9721/KJFST.2015.47.5.545 총설 ©The Korean Society of Food Science and Technology Oxyresveratrol의 기원, 생합성, 생물학적 활성 및 약물동력학 임영희·김기현 1·김정근 1,* 고려대학교 보건과학대학 바이오시스템의과학부, 1한국산업기술대학교 생명화학공학과 Source, Biosynthesis, Biological Activities and Pharmacokinetics of Oxyresveratrol 1 1, Young-Hee Lim, Ki-Hyun Kim , and Jeong-Keun Kim * School of Biosystem and Biomedical Science, Korea University 1Department of Chemical Engineering and Biotechnology, Korea Polytechnic University Abstract Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax china, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.
    [Show full text]