Quantum Clocks Observe Classical and Quantum Time Dilation ✉ ✉ Alexander R
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Revealing the Immune Perturbation of Black Phosphorus Nanomaterials to Macrophages by Understanding the Protein Corona
ARTICLE DOI: 10.1038/s41467-018-04873-7 OPEN Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona Jianbin Mo 1,2, Qingyun Xie3, Wei Wei 1,2 & Jing Zhao 1 The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. 1234567890():,; Here we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, 75.8% of the proteins bound to BP quantum dots were immune relevant proteins, while that percentage for BP nanosheet–corona complexes is 69.9%. In particular, the protein corona dramatically reshapes BP nanomaterial–corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2–4-fold. BP nanomaterials induce immunotoxicity and immune per- turbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies. 1 State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210093, China. 2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. 3 Department of Orthopedics, Chengdu Military General Hospital, Chengdu -
Mixing Indistinguishable Systems Leads to a Quantum Gibbs Paradox ✉ ✉ ✉ Benjamin Yadin 1,2 , Benjamin Morris 1 & Gerardo Adesso 1
ARTICLE https://doi.org/10.1038/s41467-021-21620-7 OPEN Mixing indistinguishable systems leads to a quantum Gibbs paradox ✉ ✉ ✉ Benjamin Yadin 1,2 , Benjamin Morris 1 & Gerardo Adesso 1 The classical Gibbs paradox concerns the entropy change upon mixing two gases. Whether an observer assigns an entropy increase to the process depends on their ability to distinguish the gases. A resolution is that an “ignorant” observer, who cannot distinguish the gases, has 1234567890():,; no way of extracting work by mixing them. Moving the thought experiment into the quantum realm, we reveal new and surprising behaviour: the ignorant observer can extract work from mixing different gases, even if the gases cannot be directly distinguished. Moreover, in the macroscopic limit, the quantum case diverges from the classical ideal gas: as much work can be extracted as if the gases were fully distinguishable. We show that the ignorant observer assigns more microstates to the system than found by naive counting in semiclassical sta- tistical mechanics. This demonstrates the importance of accounting for the level of knowl- edge of an observer, and its implications for genuinely quantum modifications to thermodynamics. 1 School of Mathematical Sciences and Centre for the Mathematics and Theoretical Physics of Quantum Non-Equilibrium Systems, University Park, University ✉ of Nottingham, Nottingham, UK. 2 Wolfson College, University of Oxford, Oxford, UK. email: [email protected]; benjamin. [email protected]; [email protected] NATURE COMMUNICATIONS | (2021) 12:1471 | https://doi.org/10.1038/s41467-021-21620-7 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-021-21620-7 espite its phenomenological beginnings, thermodynamics work from apparently indistinguishable gases as the informed Dhas been inextricably linked throughout the past century observer. -
Arxiv:1812.08053V1 [Quant-Ph] 19 Dec 2018 This Motivates the Study of Quantum Communication Without a Shared Reference Frame [4]
Communicating without shared reference frames Alexander R. H. Smith1, ∗ 1Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA (Dated: December 20, 2018) We generalize a quantum communication protocol introduced by Bartlett et al. [New. J. Phys. 11, 063013 (2009)] in which two parties communicating do not share a classical reference frame, to the case where changes of their reference frames form a one-dimensional noncompact Lie group. Alice sends to Bob the state ρR ⊗ρS , where ρS is the state of the system Alice wishes to communicate and ρR is the state of an ancillary system serving as a token of her reference frame. Because Bob is ignorant of the relationship between his reference frame and Alice's, he will describe the state ρR ⊗ ρS as an average over all possible reference frames. Bob measures the reference token and applies a correction to the system Alice wished to communicate conditioned on the outcome of the 0 measurement. The recovered state ρS is decohered with respect to ρS , the amount of decoherence depending on the properties of the reference token ρR. We present an example of this protocol when Alice and Bob do not share a reference frame associated with the one-dimensional translation group 0 and use the fidelity between ρS and ρS to quantify the success of the recovery operation. I. INTRODUCTION quire highly entangled states of many qubits. Another possibility for Alice and Bob to communicate Most quantum communication protocols assume that without a shared reference frame is for Alice to send Bob the parties communicating share a classical background a quantum system ρR to serve as a token of her reference reference frame. -
Ultra-Efficient Frequency Comb Generation in Algaas-On-Insulator
ARTICLE https://doi.org/10.1038/s41467-020-15005-5 OPEN Ultra-efficient frequency comb generation in AlGaAs-on-insulator microresonators ✉ Lin Chang1,7, Weiqiang Xie1,7 , Haowen Shu1,2,7, Qi-Fan Yang 3, Boqiang Shen 3, Andreas Boes 1,4, Jon D. Peters1, Warren Jin1, Chao Xiang1, Songtao Liu 1, Gregory Moille5, Su-Peng Yu6, Xingjun Wang2, ✉ Kartik Srinivasan 5, Scott B. Papp 6, Kerry Vahala 3 & John E. Bowers1 Recent advances in nonlinear optics have revolutionized integrated photonics, providing on- 1234567890():,; chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials feature much higher nonlinear coefficients and convenience in active integration, they have suffered from high waveguide losses that prevent the realization of efficient nonlinear processes on-chip. Here, we challenge this status quo and demonstrate a low loss AlGaAs-on-insulator platform with anomalous dispersion and quality (Q) factors beyond 1.5 × 106. Such a high quality factor, combined with high nonlinear coefficient and small mode volume, enabled us to demonstrate a Kerr frequency comb threshold of only ∼36 µW in a resonator with a 1 THz free spectral range, ∼100 times lower compared to that in previous semiconductor platforms. Moreover, combs with broad spans (>250 nm) have been generated with a pump power of ∼300 µW, which is lower than the threshold power of state-of the-art dielectric micro combs. A soliton-step transition has also been observed for the first time in an AlGaAs resonator. -
THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT the USAGE of SCHOLARLY BOOKS? White Paper
springernature.com Illustration inspired by the work of Jean-Claude Bradley Open Research THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT THE USAGE OF SCHOLARLY BOOKS? White paper Open Research: Journals, books, data and tools from: 2 The OA effect: How does open access affect the usage of scholarly books? springernature.com Contents Authors Foreword . 3 Christina Emery, Mithu Lucraft, Executive summary . 4 Agata Morka, Ros Pyne Introduction . 5 November 2017 Part 1: Quantitative findings . 6 Summary . 6 Downloads . 7 Citations and mentions . 11 Part 2: Qualitative findings . 13 Summary . 13 Reasons for publishing open access . 14 Experience of publishing open access . 15 The future of open access . 16 Discussion . 18 Conclusion and recommendations . 20 Acknowledgements . 22 Contacts . 23 About Springer Nature and OA books . 24 Appendices . 26 Appendix 1: Definitions and limitations . 26 Appendix 2: Methodology . 27 Appendix 3: Top 10 downloaded books . 29 Appendix 4: Interviewed authors and funders . 30 Appendix 5: Author questionnaire . 32 Appendix 6: Funder questionnaire . 33 Appendix 7: References . 34 This work is licensed under a Creative Commons Attribution International License (CC BY 4.0) The OA effect: How does open access affect the usage of scholarly books? springernature.com 3 Foreword Springer Nature was created in 2015, but from our earliest days as Springer, Palgrave Macmillan and Nature, we have been publishing monographs and long-form research for some 175 years. The changing environment for book publishing has created both opportunities and challenges for researchers and their funders, for publishers, and for the wider community of readers and educators. As a publisher, we have championed new models of scholarship, introducing ebooks in 2006, and our first open access (OA) book in 2011. -
SUBMISSION from SPRINGER NATURE Making Plan S Successful
PLAN S IMPLEMENTATION GUIDANCE: SUBMISSION FROM SPRINGER NATURE Springer Nature welcomes the opportunity to provide feedback to the cOAlition S Implementation Guidance and contribute to the discussion on how the transition to Open Access (OA) can be accelerated. Our submission below focuses mainly on the second question posed in the consultation: Are there other mechanisms or requirements funders should consider to foster full and immediate Open Access of research outputs? Making Plan S successful: a commitment to open access Springer Nature is dedicated to accelerating the adoption of Open Access (OA) publishing and Open Research techniques. As the world’s largest OA publisher we are a committed partner for cOAlition S funders in achieving this goal which is also the primary focus of Plan S. Our recommendations below are therefore presented with the aim of achieving this goal. As a first mover, we know the (multiple) challenges that need to be overcome: funding flows that need to change, a lack of cooperation in funder policies, a lack of global coordination, the need for a cultural change in researcher assessment and metrics in research, academic disciplines that lack OA resources, geographic differences in levels of research output making global “Publish and Read” deals difficult and, critically, an author community that does not yet view publishing OA as a priority. While this uncertainty remains, we need the benefits of OA to be better described and promoted as well as support for the ways that enable us and other publishers to cope with the rapidly increasing demand. We therefore propose cOAlition S adopt the following six recommendations which we believe are necessary to deliver Plan S’s primary goal of accelerating the take-up of OA globally while minimising costs to funders and other stakeholders: 1. -
Nature: Communications
ARTICLE https://doi.org/10.1038/s41467-019-09736-3 OPEN Water quality improvements offset the climatic debt for stream macroinvertebrates over twenty years Ian P. Vaughan 1,2 & Nicholas J. Gotelli2 Many species are accumulating climatic debt as they fail to keep pace with increasing global temperatures. In theory, concomitant decreases in other stressors (e.g. pollution, fragmen- 1234567890():,; tation) could offset some warming effects, paying climatic debt with accrued environmental credit. This process may be occurring in many western European rivers. We fit a Markov chain model to ~20,000 macroinvertebrate samples from England and Wales, and demon- strate that despite large temperature increases 1991–2011, macroinvertebrate communities remained close to their predicted equilibrium with environmental conditions. Using a novel analysis of multiple stressors, an accumulated climatic debt of 0.64 (±0.13 standard error) °C of warming was paid by a water-quality credit equivalent to 0.89 (±0.04)°C of cooling. Although there is finite scope for mitigating additional climate warming in this way, water quality improvements appear to have offset recent temperature increases, and the concept of environmental credit may be a useful tool for communicating climate offsetting. 1 Cardiff School of Biosciences and Water Research Institute, Cardiff University, Cardiff CF10 3AX, UK. 2 Department of Biology, University of Vermont, Burlington, VT 05405, USA. Correspondence and requests for materials should be addressed to I.P.V. (email: [email protected]) NATURE COMMUNICATIONS | (2019) 10:1956 | https://doi.org/10.1038/s41467-019-09736-3 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-019-09736-3 n response to global climate change, species will either shift in Across a series of analyses using ~20–26,000 high-quality, stan- distribution as they track their preferred climate, adapt locally, dardised benthic macroinvertebrate samples collected from I 1,2 or decline in abundance ultimately to extinction . -
Reference Frame Induced Symmetry Breaking on Holographic Screens
S S symmetry Article Reference Frame Induced Symmetry Breaking on Holographic Screens Chris Fields 1,* , James F. Glazebrook 2,† and Antonino Marcianò 3,‡ 1 23 Rue des Lavandières, 11160 Caunes Minervois, France 2 Department of Mathematics and Computer Science, Eastern Illinois University, Charleston, IL 61920, USA; [email protected] 3 Center for Field Theory and Particle Physics, Department of Physics, Fudan University, Shanghai 200433, China; [email protected] * Correspondence: fi[email protected]; Tel.: +33-6-44-20-68-69 † Adjunct Faculty: Department of Mathematics, University of Illinois at Urbana–Champaign, Urbana, IL 61820, USA. ‡ Also: Laboratori Nazionali di Frascati INFN, Frascati, Rome 00044, Italy. Abstract: Any interaction between finite quantum systems in a separable joint state can be viewed as encoding classical information on an induced holographic screen. Here we show that when such an interaction is represented as a measurement, the quantum reference frames (QRFs) deployed to identify systems and pick out their pointer states induce decoherence, breaking the symmetry of the holographic encoding in an observer-relative way. Observable entanglement, contextuality, and classical memory are, in this representation, logical and temporal relations between QRFs. Sharing entanglement as a resource requires a priori shared QRFs. Keywords: black hole; contextuality; decoherence; quantum error-correcting code; quantum refer- ence frame; system identification; channel theory Citation: Fields, C.; Glazebrook, J.F.; Marcianò, A. Reference Frame Induced Symmetry Breaking on Holographic Screens. Symmetry 2021, 1. Introduction 13, 408. https://doi.org/10.3390/ The holographic principle (HP) states, in its covariant formulation, that for any finite sym13030408 spacelike boundary B, open or closed, the classical, thermodynamic entropy S(L(B)) of Academic Editor: Kazuharu Bamba any light-sheet L(B) of B satisfies: S(L(B)) ≤ A(B) Received: 9 February 2021 /4 , (1) Accepted: 27 February 2021 where A(B) is the area of B in Planck units [1]. -
Tracking the Popularity and Outcomes of All Biorxiv Preprints
1 Meta-Research: Tracking the popularity and outcomes of all bioRxiv 2 preprints 3 Richard J. Abdill1 and Ran Blekhman1,2 4 1 – Department of Genetics, Cell Biology, and Development, University of Minnesota, 5 Minneapolis, MN 6 2 – Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, 7 MN 8 9 ORCID iDs 10 RJA: 0000-0001-9565-5832 11 RB: 0000-0003-3218-613X 12 13 Correspondence 14 Ran Blekhman, PhD 15 University of Minnesota 16 MCB 6-126 17 420 Washington Avenue SE 18 Minneapolis, MN 55455 19 Email: [email protected] 1 20 Abstract 21 The growth of preprints in the life sciences has been reported widely and is 22 driving policy changes for journals and funders, but little quantitative information has 23 been published about preprint usage. Here, we report how we collected and analyzed 24 data on all 37,648 preprints uploaded to bioRxiv.org, the largest biology-focused preprint 25 server, in its first five years. The rate of preprint uploads to bioRxiv continues to grow 26 (exceeding 2,100 in October 2018), as does the number of downloads (1.1 million in 27 October 2018). We also find that two-thirds of preprints posted before 2017 were later 28 published in peer-reviewed journals, and find a relationship between the number of 29 downloads a preprint has received and the impact factor of the journal in which it is 30 published. We also describe Rxivist.org, a web application that provides multiple ways 31 to interact with preprint metadata. 32 Introduction 33 In the 30 days of September 2018, four leading biology journals – The Journal of 34 Biochemistry, PLOS Biology, Genetics and Cell – published 85 full-length research 35 articles. -
Equivalence of the Symbol Grounding and Quantum System Identification Problems
Information 2014, 5, 172-189; doi:10.3390/info5010172 OPEN ACCESS information ISSN 2078-2489 www.mdpi.com/journal/information Article Equivalence of the Symbol Grounding and Quantum System Identification Problems Chris Fields 528 Zinnia Court, Sonoma, CA 95476, USA; E-Mail: fi[email protected]; Tel.: +1-707-980-5091 Received: 13 November 2013; in revised form: 4 December 2013 / Accepted: 26 February 2014 / Published: 27 February 2014 Abstract: The symbol grounding problem is the problem of specifying a semantics for the representations employed by a physical symbol system in a way that is neither circular nor regressive. The quantum system identification problem is the problem of relating observational outcomes to specific collections of physical degrees of freedom, i.e., to specific Hilbert spaces. It is shown that with reasonable physical assumptions these problems are equivalent. As the quantum system identification problem is demonstrably unsolvable by finite means, the symbol grounding problem is similarly unsolvable. Keywords: decoherence; decompositional equivalence; physical symbol system; observable-dependent exchange symmetry; semantics; tensor-product structure 1. Introduction The symbol grounding problem (SGP) was introduced by Harnad [1] as a generalization and clarification of the semantic under-determination issues raised by Searle [2] in his famous “Chinese room” argument. With reference to a “physical symbol system” model of cognition that posits purely syntactic operations (e.g., [3–6]), Harnad stated the SGP as follows: How can the semantic interpretation of a formal symbol system be made intrinsic to the system, rather than just parasitic on the meanings in our heads? How can the meanings of the meaningless symbol tokens, manipulated solely on the basis of their (arbitrary) shapes, be grounded in anything but other meaningless symbols? [1] (p. -
Are Right Angles Special? the Optimal Primitive Reference Frame
Optimal primitive reference frames. David Jennings1, 2 1Institute for Mathematical Sciences, Imperial College London, London SW7 2BW, United Kingdom 2QOLS, The Blackett Laboratory, Imperial College London, Prince Consort Road, SW7 2BW, United Kingdom (Dated: November 2, 2018) We consider the smallest possible directional reference frames allowed and determine the best one can ever do in preserving quantum information in various scenarios. We find that for the preservation of a single spin state, two orthogonal spins are optimal primitive reference frames, and in a product state do approximately 22% as well as an infinite-sized classical frame. By adding a small amount of entanglement to the reference frame this can be raised to 2(2/3)5 = 26%. Under the different criterion of entanglement-preservation a very similar optimal reference frame is found, however this time for spins aligned at an optimal angle of 87 degrees. In this case 24% of the negativity is preserved. The classical limit is considered numerically, and indicates under the criterion of entanglement preservation, that 90 degrees is selected out non-monotonically, with a peak optimal angle of 96.5 degrees for L = 3 spins. PACS numbers: 03.67.-a, 03.65.Ud, 03.65.Ta I. INTRODUCTION not. In the absence of a shared classical frame, the di- rectionality must be encoded in quantum systems QRFA In information processing it is generally assumed that and QRFB that accompany the two halves of the singlet a large, classical background reference frame is defined state. The quantum information, here entanglement, is and readily available. For example, to measure the spin only partially preserved in the relational properties of of a particle along a certain axis, a Cartesian frame is the composite state. -
Time Contraction Within Lightweight Reference Frames
Braz J Phys (2017) 47:333–338 DOI 10.1007/s13538-017-0501-4 GENERAL AND APPLIED PHYSICS Time Contraction Within Lightweight Reference Frames Matheus F. Savi1 · Renato M. Angelo1 Received: 3 April 2017 / Published online: 20 April 2017 © Sociedade Brasileira de F´ısica 2017 Abstract The special theory of relativity teaches us that, its position, velocity, energy, mass, spin, charge, tempera- although distinct inertial frames perceive the same dynam- ture, and wave function? Some people would answer this ical laws, space and time intervals differ in value. We question in the affirmative by arguing that one can always revisit the problem of time contraction using the paradig- consider an immaterial reference system for which such matic model of a fast-moving laboratory within which a assertions would make sense. In contrast, we defend that photon is emitted and posteriorly absorbed. In our model, this position is not useful in physics because, within any sci- however, the laboratory is composed of two independent entific theory, we always look for a description that can be parallel plates, each of which allowed to be sufficiently light empirically verified by some observer. Now, the notion of so as to get kickbacks upon emission and absorption of “observer” does not need to be linked with a brain-endowed light. We show that the lightness of the laboratory accentu- organism. It suffices to think of a laboratory equipped with ates the time contraction. We also discuss how the photon apparatuses whose measurement outcomes make reference frequency shifts upon reflection in a light moving mirror. to a space-time structure, which is defined by rods and Although often imperceptible, these effects will inevitably clocks rigidly attached to this laboratory.