Tracking the Popularity and Outcomes of All Biorxiv Preprints
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Revealing the Immune Perturbation of Black Phosphorus Nanomaterials to Macrophages by Understanding the Protein Corona
ARTICLE DOI: 10.1038/s41467-018-04873-7 OPEN Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona Jianbin Mo 1,2, Qingyun Xie3, Wei Wei 1,2 & Jing Zhao 1 The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. 1234567890():,; Here we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, 75.8% of the proteins bound to BP quantum dots were immune relevant proteins, while that percentage for BP nanosheet–corona complexes is 69.9%. In particular, the protein corona dramatically reshapes BP nanomaterial–corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2–4-fold. BP nanomaterials induce immunotoxicity and immune per- turbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies. 1 State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering Nanjing University, Nanjing 210093, China. 2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. 3 Department of Orthopedics, Chengdu Military General Hospital, Chengdu -
Gies for Increasing Citations
CORE Metadata, citation and similar papers at core.ac.uk Provided by International SERIES on Information Systems and Management in Creative eMedia (CreMedia) Maximized Research Impact: Effective Strate- gies for Increasing Citations Nader Ale Ebrahim*1, Hossein Gholizadeh2, Artur Lugmayr3 1Research Support Unit, Centre for Research Services, Institute of Research Management and Monitoring (IPPP), University of Malaya, Malaysia, Email: [email protected], *Corresponding author 2Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia 3VisLab., School of Media, Culture and Creative Arts, Curtin University, Perth, Australia Abstract The high competitive environment has forced higher education authori- ties to set their strategies to improve university ranking. Citations of published pa- pers are among the most widely used inputs to measure national and global uni- versity ranking (which accounts for 20% of QS, 30% of THE, and etc.). Therefore, from one hand, improving the citation impact of a search is one of the university manager’s strategies. On the other hand, the researchers are also looking for some helpful techniques to increase their citation record. This chapter by reviewing the relevant articles covers 48 different strategies for maximizing research impact and visibility. The results show that some features of article can help predict the num- ber of article views and citation counts. The findings presented in this chapter could be used by university authorities, authors, reviewers, and editors to maxim- ize the impact of articles in the scientific community. Keywords: University ranking, Improve citation, Citation frequency, Research impact, Open access, h-index Introduction The research output is an essential part of an institution’s measure and evaluation of research quality. -
High-Throughput Analysis Suggests Differences in Journal False
Hall and Hendricks BMC Bioinformatics (2020) 21:564 https://doi.org/10.1186/s12859‑020‑03817‑7 RESEARCH ARTICLE Open Access High‑throughput analysis suggests diferences in journal false discovery rate by subject area and impact factor but not open access status L. M. Hall1 and A. E. Hendricks1,2* *Correspondence: audrey.hendricks@ucdenver. Abstract edu Background: A low replication rate has been reported in some scientifc areas 1 Mathematical and Statistical Sciences, University motivating the creation of resource intensive collaborations to estimate the replica- of Colorado Denver, Denver, tion rate by repeating individual studies. The substantial resources required by these CO, USA projects limits the number of studies that can be repeated and consequently the Full list of author information is available at the end of the generalizability of the fndings. We extend the use of a method from Jager and Leek article to estimate the false discovery rate for 94 journals over a 5-year period using p values from over 30,000 abstracts enabling the study of how the false discovery rate varies by journal characteristics. Results: We fnd that the empirical false discovery rate is higher for cancer versus general medicine journals (p 9.801E 07, 95% CI: 0.045, 0.097; adjusted mean false discovery rate cancer 0.264= vs. general− medicine 0.194). We also fnd that false discovery rate is negatively= associated with log journal= impact factor. A two-fold decrease in journal impact factor is associated with an average increase of 0.020 in FDR (p 2.545E 04). Conversely, we fnd no statistically signifcant evidence of a higher= false discovery− rate, on average, for Open Access versus closed access journals (p 0.320, 95% CI 0.015, 0.046, adjusted mean false discovery rate Open Access 0.241= vs. -
List Stranica 1 Od
list product_i ISSN Primary Scheduled Vol Single Issues Title Format ISSN print Imprint Vols Qty Open Access Option Comment d electronic Language Nos per volume Available in electronic format 3 Biotech E OA C 13205 2190-5738 Springer English 1 7 3 Fully Open Access only. Open Access. Available in electronic format 3D Printing in Medicine E OA C 41205 2365-6271 Springer English 1 3 1 Fully Open Access only. Open Access. 3D Display Research Center, Available in electronic format 3D Research E C 13319 2092-6731 English 1 8 4 Hybrid (Open Choice) co-published only. with Springer New Start, content expected in 3D-Printed Materials and Systems E OA C 40861 2363-8389 Springer English 1 2 1 Fully Open Access 2016. Available in electronic format only. Open Access. 4OR PE OF 10288 1619-4500 1614-2411 Springer English 1 15 4 Hybrid (Open Choice) Available in electronic format The AAPS Journal E OF S 12248 1550-7416 Springer English 1 19 6 Hybrid (Open Choice) only. Available in electronic format AAPS Open E OA S C 41120 2364-9534 Springer English 1 3 1 Fully Open Access only. Open Access. Available in electronic format AAPS PharmSciTech E OF S 12249 1530-9932 Springer English 1 18 8 Hybrid (Open Choice) only. Abdominal Radiology PE OF S 261 2366-004X 2366-0058 Springer English 1 42 12 Hybrid (Open Choice) Abhandlungen aus dem Mathematischen Seminar der PE OF S 12188 0025-5858 1865-8784 Springer English 1 87 2 Universität Hamburg Academic Psychiatry PE OF S 40596 1042-9670 1545-7230 Springer English 1 41 6 Hybrid (Open Choice) Academic Questions PE OF 12129 0895-4852 1936-4709 Springer English 1 30 4 Hybrid (Open Choice) Accreditation and Quality PE OF S 769 0949-1775 1432-0517 Springer English 1 22 6 Hybrid (Open Choice) Assurance MAIK Acoustical Physics PE 11441 1063-7710 1562-6865 English 1 63 6 Russian Library of Science. -
Ultra-Efficient Frequency Comb Generation in Algaas-On-Insulator
ARTICLE https://doi.org/10.1038/s41467-020-15005-5 OPEN Ultra-efficient frequency comb generation in AlGaAs-on-insulator microresonators ✉ Lin Chang1,7, Weiqiang Xie1,7 , Haowen Shu1,2,7, Qi-Fan Yang 3, Boqiang Shen 3, Andreas Boes 1,4, Jon D. Peters1, Warren Jin1, Chao Xiang1, Songtao Liu 1, Gregory Moille5, Su-Peng Yu6, Xingjun Wang2, ✉ Kartik Srinivasan 5, Scott B. Papp 6, Kerry Vahala 3 & John E. Bowers1 Recent advances in nonlinear optics have revolutionized integrated photonics, providing on- 1234567890():,; chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials feature much higher nonlinear coefficients and convenience in active integration, they have suffered from high waveguide losses that prevent the realization of efficient nonlinear processes on-chip. Here, we challenge this status quo and demonstrate a low loss AlGaAs-on-insulator platform with anomalous dispersion and quality (Q) factors beyond 1.5 × 106. Such a high quality factor, combined with high nonlinear coefficient and small mode volume, enabled us to demonstrate a Kerr frequency comb threshold of only ∼36 µW in a resonator with a 1 THz free spectral range, ∼100 times lower compared to that in previous semiconductor platforms. Moreover, combs with broad spans (>250 nm) have been generated with a pump power of ∼300 µW, which is lower than the threshold power of state-of the-art dielectric micro combs. A soliton-step transition has also been observed for the first time in an AlGaAs resonator. -
Estimated Costs of Implementing an Open Access Policy at a Private Foundation
bioRxiv preprint doi: https://doi.org/10.1101/128413; this version posted August 17, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Estimated costs of implementing an open access policy at a private foundation 1 2 Carly Strasser and Eesha Khare 1 Gordon and Betty Moore Foundation, Palo Alto, California, USA 2 Harvard University, Cambridge, Massachusetts, USA Corresponding author: Carly Strasser1 Email address: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/128413; this version posted August 17, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract Background: The Gordon and Betty Moore Foundation (GBMF) was interested in understanding the potential effects of a policy requiring open access to peer-reviewed publications resulting from the research the foundation funds. Methods: We collected data on more than 2000 publications in over 500 journals that were generated by GBMF grantees since 2001. We then examined the journal policies to establish how two possible open -
Catalyzed Synthesis of Zinc Clays by Prebiotic Central Metabolites
bioRxiv preprint doi: https://doi.org/10.1101/075176; this version posted September 14, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Catalyzed Synthesis of Zinc Clays by Prebiotic Central Metabolites Ruixin Zhoua, Kaustuv Basub, Hyman Hartmanc, Christopher J. Matochad, S. Kelly Searsb, Hojatollah Valib,e, and Marcelo I. Guzman*,a *Corresponding Author: [email protected] aDepartment of Chemistry, University of Kentucky, Lexington, KY, 40506, USA; bFacility for Electron Microscopy Research, McGill University, 3640 University Street, Montreal, Quebec H3A 0C7, Canada; cEarth, Atmosphere, and Planetary Science Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; dDepartment of Plant and Soil Sciences, University of Kentucky, Lexington, KY, 40546, USA; eDepartment of Anatomy & Cell Biology, 3640 University Street, Montreal H3A 0C7, Canada The authors declare no competing financial interest. Number of text pages: 20 Number of Figures: 9 Number of Tables: 0 bioRxiv preprint doi: https://doi.org/10.1101/075176; this version posted September 14, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract How primordial metabolic networks such as the reverse tricarboxylic acid (rTCA) cycle and clay mineral catalysts coevolved remains a mystery in the puzzle to understand the origin of life. -
Downloads Presented on the Abstract Page
bioRxiv preprint doi: https://doi.org/10.1101/2020.04.27.063578; this version posted April 28, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. A systematic examination of preprint platforms for use in the medical and biomedical sciences setting Jamie J Kirkham1*, Naomi Penfold2, Fiona Murphy3, Isabelle Boutron4, John PA Ioannidis5, Jessica K Polka2, David Moher6,7 1Centre for Biostatistics, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom. 2ASAPbio, San Francisco, CA, USA. 3Murphy Mitchell Consulting Ltd. 4Université de Paris, Centre of Research in Epidemiology and Statistics (CRESS), Inserm, Paris, F-75004 France. 5Meta-Research Innovation Center at Stanford (METRICS) and Departments of Medicine, of Epidemiology and Population Health, of Biomedical Data Science, and of Statistics, Stanford University, Stanford, CA, USA. 6Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada. 7School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada. *Corresponding Author: Professor Jamie Kirkham Centre for Biostatistics Faculty of Biology, Medicine and Health The University of Manchester Jean McFarlane Building Oxford Road Manchester, M13 9PL, UK Email: [email protected] Tel: +44 (0)161 275 1135 bioRxiv preprint doi: https://doi.org/10.1101/2020.04.27.063578; this version posted April 28, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. -
Systems Biology Behind Immunoprotection of Both Sheep and Goats After 2 Sungri/96 PPRV Vaccination
bioRxiv preprint doi: https://doi.org/10.1101/2020.08.14.252056; this version posted August 15, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Systems Biology behind immunoprotection of both Sheep and Goats after 2 Sungri/96 PPRV vaccination 3 Sajad Ahmad Wani1,2#, Manas Ranjan Praharaj3#, Amit R Sahu1, Raja Ishaq Nabi 4 Khan1, Kaushal Kishor Rajak1, Dhanavelu Muthuchelvan4, Aditya Sahoo5, Bina 5 Mishra1, R. K. Singh1*, Bishnu Prasad Mishra1* and Ravi Kumar Gandham3* 6 1 ICAR-Indian Veterinary Research Institute (IVRI), Bareilly, India 7 2 The Ohio State University, Columbus, OH, United States 8 3 DBT-National Institute of Animal Biotechnology, Hyderabad, India 9 4 ICAR-Indian Veterinary Research Institute (IVRI), Mukteswar, India 10 5 ICAR- Directorate of Foot and Mouth Disease, Mukteswar, India 11 # Equal Contributors 12 * Corresponding Authors: Ravi Kumar Gandham, [email protected] 13 Bishnu Prasad Mishra, [email protected] 14 Raj Kumar Singh, [email protected] 15 16 Abstract 17 Immune response is a highly coordinated cascade involving all the subsets of 18 PBMCs. In this study, RNA-Seq analysis of PBMC subsets - CD4+, CD8+, CD14+, 19 CD21+ and CD335+ cells from day 0 and day 5 of Sungri/96 Peste des Petits 20 Ruminants vaccinated sheep and goats was done to delineate the systems biology 21 behind immune - protection of the vaccine in sheep and goats. Assessment of the 22 immune response processes enriched by the differentially expressed genes in all the 23 subsets suggested a strong dysregulation towards development of early inflammatory 24 microenvironment, which is very much required for differentiation of monocytes to 25 macrophages, and for activation and migration of dendritic cells into the draining lymph 26 nodes. -
SPRINGER NATURE Products, Services & Solutions 2 Springer Nature Products, Services & Solutions Springernature.Com
springernature.com Illustration inspired by the work of Marie Curie SPRINGER NATURE Products, Services & Solutions 2 Springer Nature Products, Services & Solutions springernature.com About Springer Nature Springer Nature advances discovery by publishing robust and insightful research, supporting the development of new areas of knowledge, making ideas and information accessible around the world, and leading the way on open access. Our journals, eBooks, databases and solutions make sure that researchers, students, teachers and professionals have access to important research. Springer Established in 1842, Springer is a leading global scientific, technical, medical, humanities and social sciences publisher. Providing researchers with quality content via innovattive products and services, Springer has one of the most significant science eBooks and archives collections, as well as a comprehensive range of hybrid and open access journals. Nature Research Publishing some of the most significant discoveries since 1869. Nature Research publishes the world’s leading weekly science journal, Nature, in addition to Nature- branded research and review subscription journals. The portfolio also includes Nature Communications, the leading open access journal across all sciences, plus a variety of Nature Partner Journals, developed with institutions and societies. Academic journals on nature.com Prestigious titles in the clinical, life and physical sciences for communities and established medical and scientific societies, many of which are published in partnership a society. Adis A leading international publisher of drug-focused content and solutions. Adis supports work in the pharmaceutical and biotech industry, medical research, practice and teaching, drug regulation and reimbursement as well as related finance and consulting markets. Apress A technical publisher of high-quality, practical content including over 3000 titles for IT professionals, software developers, programmers and business leaders around the world. -
John Inglis: Getting up to Speed with Preprints
GETTING UP TO SPEED WITH PREPRINTS: WHERE WE CAME FROM, WHERE WE ARE NOW John Inglis Ph.D. Co-founder, bioRxiv and medRxiv Cold Spring Harbor Laboratory @JohnRInglis [email protected] Conference on Research Integrity June 2, 2019 Hong Kong Outline • A brief history of preprints • The current growth of preprints • Integration of preprints into the scholarly communication ecosystem • The potential of preprints Disclosures: John Inglis PhD Cold Spring Harbor Laboratory • Professor • Executive Director and Publisher, Cold Spring Harbor Laboratory Press • Executive Committee Member and Academic Mentor, School of Biological Sciences • Co-founder, bioRxiv and medRxiv External positions • Director, Life Science Alliance LLC • Advisory Board Member, MIT Press • Advisory committee member, The Royal Society Grants • Gates Foundation: funding for You, Me, and HIV education project in South Africa • Solebury Trout LLC: financial support for A Cure Within • Flowers Foundation: financial support for Malaria: Biology in the Era of Eradication • Chan Zuckerberg Initiative: major support for bioRxiv Definitions Preprint (n): a research manuscript its authors choose to distribute before its acceptance by a journal Preprint server (n): a website dedicated to the distribution of preprints A brief history of preprints • Informal sharing by snail mail • NIH Information Exchange Groups 1960-1967 • Email sharing of physics preprints by Joanne Cohn in 1990’s • Not-for-profit arXiv launched in 1991 at Los Alamos Laboratory • Social Science Research Network, founded -
Library Connect Digest 2017.Indd
Library Connect Digest 2017 Elsevier’s Library Connect program thanks the librarians, information professionals and scholars from around the world who contributed to the webinars and newsletter in 2017. TABLE OF CONTENTS Editor’s Note: Some of the resource links may have changed since their original publication. If you have difficulty finding a resource, please email us at [email protected]. INFORMATION DISCOVERY & LITERACY | literature search, research support, text mining, APIs Articles 4-5 Providing literature support as part of the biomedical research team 6-7 Information literacy resources for librarians and their library users 8-10 Knowledge discovery through text analytics: advances, challenges and opportunities 11 To librarians from a PhD researcher 12-13 Tracking student success in literature search as they avoid detrimental detours 14-15 Literature search — download a helpful handout for library users in their most desperate hour Additional Resources 16 WEBINAR March 16 | 12 time-saving tips for research support 16 WEBINAR Sept. 29 | Literature search on a connected path 16 WEBINAR Oct. 19 | Librarians and APIs 101: overview and use cases LIBRARIAN ROLES | liaison, corporate, journal editor, grants Articles 17-19 Building a successful liaison program from the ground up 20-21 “A good one”: Meet Elsevier’s new VP of global library relations 22-23 Do you want to be an LIS journal editor? An editor discusses perks and pitfalls 24-25 Partnering to support grant-funded research: learn the jargon and look for needs 26-27 Medtronic Knowledge Center redesign a sign of collaborative spirit and company support Additional Resources 28 WEBINAR May 18 | High-impact library services and outreach METRICS | research metrics, institutional data, CiteScore Articles 29-30 Eureka points on the Research Assessment Metrics Timeline 31-32 Keeping score of CiteScore 33-34 CiteScore™ metrics resources for LibGuides Additional Resources 35 WEBINAR June 8 | Researcher profiles and metrics that matter 35 WEBINAR Nov.