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2018 Media Kit

Impactful Springer Nature brands, influential readership and content that drives discovery.

ASTRONOMY SPRINGER NATURE...... 2 BEHAVIORAL SCIENCES BIOMEDICAL SCIENCES OUR AUDIENCE & REACH...... 3 BIOPHARMA CELLULAR BIOLOGY ADVERTISING SOLUTIONS & CHEMISTRY EARTH SCIENCES PARTNERING OPPORTUNITIES...... 6 ELECTRONICS JOURNAL AUDIENCE & CALENDARS...... 8 ENERGY ENGINEERING SCIENTIFIC DISCIPLINES...... 17 ENVIRONMENTAL SCIENCES GENETICS A-Z JOURNAL LIST...... 19 IMMUNOLOGY, MICROBIOLOGY LIFE SCIENCES MATERIALS SCIENCES MEDICINE METHODS, PROTOCOLS MULTIDISCIPLINARY NEUROLOGY, NEUROSCIENCE ONCOLOGY, CANCER RESEARCH PHARMACOLOGY PHYSICS PLANT SCIENCES SPRINGER NATURE

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Springer Nature is a leading publisher of scientific, scholarly, professional and educational content. For more than a century, our brands have set the scientific agenda. We’ve published ground-breaking work on many fundamental achievements, including the splitting of the atom, the structure of DNA, and the discovery of the hole in the ozone layer, as well as the latest advances in stem-cell research and the results of the ENCODE project. Our dominance in the scientific publishing market comes from a company-wide philosophy to uphold the highest level of quality for our readers, authors and commercial partners.

Our family of trusted scientific brands receive 131 MILLION* page views each month reaching an audience of over 40 MILLION*.^

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More Nobel laureates 15 journals rank #1 in one or more subject category** published with us than any other 12 titles AMONG THE by 5 year Impact factor** scientific publisher 11 titles TOP 20 SCIENCE by Article Influence Score** 5 titles JOURNALS by Immediacy Index**

NATURE RESEARCH IMPACTFUL BRANDS

Nature Research is a portfolio of high-quality products and services across the life, physical, chemical and applied sciences, including journals, online databases and researcher services – dedicated to serving the scientific community. Nature (founded in 1869) is the leading weekly, international scientific journal and sits at the heart of the brand. Nature Research also publishes a range of Nature- branded research and reviews subscription journals, alongside leading open-access multidisciplinary journal Nature Communications and other open-access journals.

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2 | Life & Physical Sciences | Media Kit 2018 *Webtrends 2017, Webtrekk 2017, Google Analytics 2017 | **2016 Journal Citation Reports® Science Edition (Clarivate Analytics, 2017) | ^These figures are a combined total of page views and unique users of nature.com, link.springer.com, scientificamerican.com, natureasia.com, and biomedcentral.com. (January-June 2017) OUR AUDIENCE & REACH PARTNERSHIPS.NATURE.COM/INFO

NATURE.COM A GROWING AND GLOBAL AUDIENCE MONTHLY PAGE VIEWS & GROWING* THE AVERAGE VISIT IS 49 M ILLION 7 MINUTES 9 SECONDS*

10.7 MILLION UNIQUE USERS PER MONTH* 48 million 49 million 45 million 44 million 45 million 41 million 40 million

Third Party Table of Contents Active Email ealert (ETOC) nature.com subscribers** subscribers** registrants***

Jan-Jun Jul-Dec Jan-Jun Jul-Dec Jan-Jun Jul-Dec Jan-Jun 139,057 535,455 2,489,001 2014 2015 2016 2017

Geographic Reach:* AMERICAS ASIA/ UK/ 39% 31% ROW 29% EUROPE

Nature.com regions

Nature.com regions Nature.com regions Nature.com regions science… wherever you are. www.natureasia.com

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Nature India is a showcase of the best of Indian scienceNature and India not ais peer-reviewed a showcase of journal.the best of Indian science and not a peer-reviewed journal. www.nature.com/nindia Nature China is dedicated to highlighting the best research being produced in Hong Kong and However, as a resource for authors and referees interestedHowever, in publishingas a resource with for other authors Nature and titles,referees interested in publishing with other Nature titles, www.nature.com/nmiddleast Mainland China in science and clinical medicine. Every month our editors survey the scienti c the 'Links on Nature' box points to information appearingthe 'Links elsewhere on Nature on ' nature.com.box points to information appearing elsewhere on nature.com. Nature India is a showcase of the best of Indian science and not a peer-reviewed journal. literature to identify the best recently published papers, from China, and provide engaging Nature Middle East is a free portal for scienti c and medical research in the Arabic-speaking However, as a resource for authors and referees interested in publishing with other Nature titles, short summaries. the 'Links on Nature' box points to information appearing elsewhere on nature.com. Middle East, covering a diverse group of 18 nations. e site has a broad scope that caters for www.nature.com/nmiddleast www.nature.com/nmiddleast Media Kit 2018 | Life & Physical Sciences | 3 Sign up to the free weekly podcast, featuring interviews scienti c and medical researchers at all levels, from students to post-doctoral fellows to principal with the scientists behind the research, and contributions *Webtrends 2017 | ** Silverpop 2017 | ***Publisher Data 2017 www.nature.com/nindia investigators. Nature Middle East publishes articles in English and Arabic, including research from Nature’s top team of editors and journalists. Nature Middle East is a free portal for scienti c and Naturemedical Middle researchwww.nature.com/nmiddleast East in isthe a freeArabic-speaking portal for scienti c and medicalhighlights, research news in the and Arabic-speaking features, an interactive blog, job vacancies and local events. Middle East, covering a diverse group of 18 nations. e site has a broad scope that caters for Nature India is a showcase of the best of Indian science and not a peer-reviewed journal. 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Middle East, covering a diverse group of 18 nations. investigators. e site has a Naturebroad scope Middle that East caters publishes for articles in English andfrom Arabic, Nature including’s top researchteam of editors and journalists.from Nature’s top team of editors and journalists. highlights, news and features, an interactive blog, job vacancies and local events. Sign up to the free weekly podcast, featuring interviews scienti c and medical researchers at all levels, from studentshighlights, to post-doctoral news and features, fellows an to interactiveprincipal blog, job vacancies and local events. nature.com/nature/podcast 140 with the scientists behind the research, and contributions investigators. Nature Middle East publishes articles in English and Arabic, including research from Nature’s top team of editors and journalists. www.nature.com/nmiddleast highlights, news and features, an interactive blog, job vacancies and local events. 24752_Nature podcast ad_Tube_V1.indd 1 18/06/2013 15:31 CatalogueNature Layout.indd Middlenature.com/ 140 East is a freenature/ portalpodcast for scienti c and medical researchnature.com/ in the Arabic-speakingnature/podcast 25/09/2014 12:12 140 Middle East, covering a diverse group of 18 nations. e site has a broad scope that caters for 140 Sign up to the free weekly podcast, featuring interviews scienti c and medical researchers at all levels, from students to post-doctoral fellows to principal nature.com/nature/podcast with the scientists behind the research, and contributions investigators.24752_Nature podcast Naturead_Tube_V1.indd Middle 1 East publishes articles in English and Arabic, including research 18/06/2013 15:31 140 24752_Nature podcast ad_Tube_V1.indd 1 from Nature’s top team of editors and journalists.18/06/2013 15:31 Catalogue Layout.indd 140 Catalogue Layout.indd 140 25/09/2014 12:12highlights, news and features, an interactive25/09/2014 blog, 12:12 job vacancies and local events.

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24752_Nature podcast ad_Tube_V1.indd 1 18/06/2013 15:31 Catalogue Layout.indd 140 25/09/2014 12:12 OUR AUDIENCE & REACH

SPRINGER NATURE AUDIENCE* INFLUENTIAL WITH PROVEN PURCHASING POWERS

$86.7K 83% ACTION TAKEN 57% Contacted/visited a average annual budget per reader AFTER SEEING Discussed/recommended company website for purchased a new more information for research products/equipment A PRODUCT ADVERTISED product/tech

of our readers AGREE that it’s important to keep 87% aware of product and technology developments 83% of our readers are DIRECTLY LEARNING ABOUT PRODUCT INVOLVED in purchasing decisions DEVELOPMENT AND TECHNOLOGY

Webcasts 10% Social networks 22% ANTIBODY- Print advertisements 22% BASED Protocols 33% TECHNIQUES 31% Newsletters 39% CELL OR TISSUE CULTURE Word of mouth 42% 32% Email 44% TOP 10 Online advertisements 49% PRODUCTS Conferences 63% ELECTRO- USED Articles 68% PHORESIS 30% NUCLEIC ACID ISOLATION/ 5% PURIFICATION 28% PCR OR RT-PCR 36% HOW MICROSCOPY DNA OR RNA SPRINGER 37% SEQUENCING 26% NATURE PROTEIN 29% JOURNALS DETECTION OR ARE READ ANALYSIS MOLECULAR 25% MOLECULAR Online BIOLOGY BIOLOGY LAB Print KITS/REAGENTS EQUIPMENT 32% 31% Both 66%

4 | Life & Physical Sciences | Media Kit 2018 *All data on pages 4-5 from Reader Survey 2017 PARTNERSHIPS.NATURE.COM/INFO

HIGHLY QUALIFIED AND ENGAGED

TOP 10 PLACES OF WORK

University/College 49%

Research Institute AGRICULTURAL 16% & BIOLOGICAL Hospital 8% SCIENCES Medical School 5% 15% Biotechnology 4% Government Institute or Agency 4% Pharmaceutical 3% BIOMEDICAL SCIENCES Engineering/Manufacturing 2% 37% Private practice 2% Consulting 1%

CHEMISTRY of readers hold POSTGRADUATE 4% 85% qualifications CLINICAL MEDICINE 16% ACADEMIC QUALIFICATIONS AREAS OF Postgraduate- Dual doctorate degree (MD-PhD) 10% INTEREST Postgraduate- Doctorate degree (PhD/DPhil/MD) EARTH & 56% ENVIRONMENTAL Postgraduate- Master’s degree (MA/MS/MSc) 19% SCIENCES Undergraduate- Bachelor’s degree (BSc/BA/BS) 4% 10% MATERIALS Other 5% SCIENCE 3% KEY JOB TITLES ENGINEERING 4%

PHYSICS 4% SOCIAL SCIENCES Early-career Scientist/ VP of Research/Principal Healthcare Professional/ 3% Students 43% Investigator/Lab Director 15% Clinicians 3% PSYCHOLOGY 3% OTHER 6%

Head of Academic Dept/ CEO/Investor/Business Consultant/Fellow/ Faculty Professor 18% Consultant/Sales 2% Attending Physician 8%

Media Kit 2018 | Life & Physical Sciences | 5 ADVERTISING SOLUTIONS & PARTNERING OPPORTUNITIES

AWARENESS Build awareness strategically with banner and print advertising solutions

New market-leading online behavioral targeting and reporting technology ensures your digital ad reaches your desired audience. Optimize viewability through the latest ad display functionality including sticky ads, lazy loading, and dynamic refresh. Amplify awareness in print advertising via bonus distribution at key conferences or by using high-impact inserts and outserts. Gain invaluable feedback via free market research in selected issues.

LEAD GENERATION Generate quality leads with email advertising and custom webcasts

Nature Research’s expansive lists have been built up over time with leading researchers engaged with our communications. Leverage our established trust with a third party email and table of contents ealerts optimizing the open rates of your message. Webcasts can instantly reach a global audience with real-time feedback. Gain valuable leads to follow up with and enhance rapport with your audience.

Looking to recruit? We also offer recruitment advertising.

6 | Life & Physical Sciences | Media Kit 2018 PARTNERSHIPS.NATURE.COM/INFO

EDUCATION Drive education through events and conferences

Educate your audience by directing the narrative, and establishing your authority in a particular area. Conferences deliver a social space to promote the scholarly discourse. Collaborate with Nature Research sales, marketing, and editorial teams to create a memorable event that is engaging, productive and serves to set the agenda in your chosen field of research.

THOUGHT LEADERSHIP Demonstrate thought leadership with Native Advertising k

Be an active participant in the community debate on a topic while building a network of key influencers withcustom articles on Nature.com. Our high editorial standards ensure your article will meet the expectations of our sophisticated audience. Clear calls to action direct readers to your brand to learn more and continue the discussion.

Position your brand alongside editorial or commercially driven content with sponsorship and custom content solutions. Leverage our respected and authoritative editorial reputation and engaged audience. Reinforce your commitment to a technological advance, awareness of a disease, therapeutic area or scientific field, further building your reputation and market exposure.

Media Kit 2018 | Life & Physical Sciences | 7 JOURNAL AUDIENCE & CALENDARS

First published in 1869, Nature is the the world’s leading multidisciplinary science journal. Nature publishes the finest peer-reviewed research that drives ground-breaking discovery, nature.com/nature and is read by thought-leaders and decision-makers around the world. The quality and prestige associated with Nature is unsurpassed.

JOURNAL METRICS* REACH GLOBAL AUDIENCE

Total Cites:...... 671,254 PRINT** #1 Journal in Multidisciplinary Sciences 53,270 print circulation 412,598 readership^ W Impact Factor:...... 40,137 o 5-Year Impact Factor:...... 43.769 ONLINE*** 8.6 million monthly page views Immediacy Index:...... 9.129 A mericas UK/E urope A sia /R 2.9 million monthly unique users Eigenfactor Score:...... 1.43399 Print** 52% 35% 13% Article Influence Score:...... 22.976 EMAIL† 528,229 alert subscribers Online*** 38% 31% 31%

of readers state they are directly average annual budget for 85% involved in purchasing decisions ‡ $90K research products/equipment ‡

AREAS OF FOCUS ‡ AGRICULTURAL & BIOLOGICAL SCIENCES 17% BIOMEDICINE 44% EARTH & ENVIRONMENTAL SCIENCES 4% Biology 60% Cell Biology/ Cell Research 47% Environmental Sciences 53% Plant Sciences 27% Biochemistry & Molecular Biology 46% Geochemistry & Geophysics 19% Evolutionary Biology 21% Medicine, Research & Experimental 28% Oceanography 18% Ecology 19% Immunology & Allergy 27% ENGINEERING 3% Agriculture, Dairy & Animal Science 12% Biomedicine 24% Biomedical Engineering 32% Neurosciences 20% Electrical & Electronic Engineering 25% CLINICAL MEDICINE 12% Genetics & Heredity 19% Mechanical Engineering 20% Oncology/Cancer Research 22% Biochemical Research Methods 17% Medicine, General & Internal 14% Biotechnology & Applied Microbiology 12% MATERIALS SCIENCE 3% Infectious Diseases 10% Microbiology 12% Characterization & Testing 47% Coatings & Films 32% CHEMISTRY 4% PHYSICS 4% Biomaterials 30% Organic Chemistry 33% Condensed Matter Physics 33% Medicinal Chemistry 31% Astronomy & Astrophysics 28% PSYCHOLOGY 3% Analytical Chemistry 29% Optics 27% SOCIAL SCIENCES 2%

TOP 10 PRODUCTS OR TECHNOLOGIES USED ‡ RESEARCHER PLACE OF WORK ‡ JOB TITLES ‡ Microscopy 46% University/College 61% Early-career Scientist/Students 48% PCR or RT-PCR 45% Research Institution 22% Head of Academic Dept./ Faculty/Professor 18% VP of Research/Principal Investigator/Lab Director 17% Cell or tissue culture 41% Industry/Corporation 9% Molecular biology kits/reagents 40% Government 5% Consultant/Fellow/Attending Physician 6% Molecular biology laboratory equipment 39% Hospital 3% Healthcare Professional/Clinicians 2% Antibody-based techniques 39% CEO/Investor/Business Consultant/Sales 2% Electrophoresis 38% Nucleic acid isolation or purification 35% DNA or RNA sequencing 33% Protein detection or analysis 32%

CALENDAR 2018 • Technology Feature – associate with emerging lab trends • Readex Research – receive free audience feedback TECHNOLOGY FEATURE / READEX RESEARCH / • Bonus Distribution - free additional distribution at conferences BONUS DISTRIBUTION / PRODUCT FOCUS • Product Focus – inform readers about your relevant products

Materials Product Focus Issue Date Special Feature Bonus Distribution Ad Close Deadline Deadline 4-Jan 20-Dec 22-Dec 11-Jan 27-Dec 29-Dec

JAN 18-Jan 3-Jan 5-Jan Product Focus: Microscopy 25-Jan 10-Jan 12-Jan 20-Dec Technology Feature: Technologies to watch 1-Feb 17-Jan 19-Jan 8-Feb READEX 24-Jan 26-Jan

FEB 15-Feb Product Focus: DNA/RNA Analysis 31-Jan 2-Feb 8-Jan 22-Feb Technology Feature: Informatics 7-Feb 9-Feb 1-Mar American Physical Society (APS) 14-Feb 16-Feb 8-Mar Society of Toxicology (SOT) 21-Feb 23-Feb 15-Mar Product Focus: Mass Spectrometry 28-Feb 2-Mar 15-Feb

MAR 22-Mar Technology Feature: Chemistry 7-Mar 9-Mar Analytica 29-Mar 14-Mar 16-Mar European Geosciences Union (EGU) 5-Apr 21-Mar 23-Mar Product Focus: Cancer Research 12-Apr American Association of Cancer Research Annual Meeting (AACR) 28-Mar 30-Mar 15-Mar Technology Feature: Cancer APR 19-Apr READEX 4-Apr 6-Apr 26-Apr 11-Apr 13-Apr 3-May American Association of Immunologists (AAI) 18-Apr 20-Apr 10-May Product Focus: Protein Analysis 25-Apr 27-Apr 12-Apr 17-May 2-May 4-May

MAY 24-May Technology Feature: Immunology American Society of Clinical Oncology (ASCO) 9-May 11-May American Society for Microbiology (ASM) 31-May 16-May 18-May Digestive Disease Week (DDW) 7-Jun Product Focus: Microbiology European Society for Human Genetics (ESHG) 23-May 25-May 10-May 14-Jun 30-May 1-Jun

JUNE 21-Jun Technology Feature: Stem Cells 6-Jun 8-Jun 28-Jun READEX 13-Jun 15-Jun 5-Jul 20-Jun 22-Jun 12-Jul Product Focus: Proteomics 27-Jun 29-Jun 7-Jun

JUL 19-Jul Technology Feature: Lab Equipment 4-Jul 6-Jul 26-Jul 11-Jul 13-Jul 2-Aug 18-Jul 20-Jul 9-Aug 25-Jul 27-Jul 16-Aug Product Focus: PCR 256th ACS National Meeting & Exposition (ACS Fall) 1-Aug 3-Aug 12-Jul AUG 23-Aug Technology Feature: Reproducibility 8-Aug 10-Aug 30-Aug 15-Aug 17-Aug 6-Sep READEX 22-Aug 24-Aug 13-Sep Product Focus: Antibodies 29-Aug 31-Aug 16-Aug

SEP 20-Sep Technology Feature: Structural Biology 5-Sep 7-Sep 27-Sep 12-Sep 14-Sep 4-Oct 19-Sep 21-Sep Product Focus: Genomics 11-Oct American Society of Human Genetics (ASHG) 26-Sep 28-Sep 18-Sep Technology Feature: Clinical Genetics OCT 18-Oct 3-Oct 5-Oct 25-Oct READEX 10-Oct 12-Oct Product Focus: Neuroscience 1-Nov Society for Neuroscience (SfN) 17-Oct 19-Oct 25-Sep Technology Feature: Neuroscience 8-Nov 24-Oct 26-Oct

NOV 15-Nov 31-Oct 2-Nov 22-Nov Materials Research Society (MRS Fall) 7-Nov 9-Nov 29-Nov 14-Nov 16-Nov Product Focus: Cell Biology American Geophysical Union (AGU) 6-Dec 21-Nov 23-Nov 1-Nov Technology Feature: Microscopy American Society for Cell Biology (ASCB)

DEC 13-Dec 28-Nov 30-Nov 20-Dec 5-Dec 7-Dec

Bonus distribution is subject to change

Media Kit 2018 | Life & Physical Sciences | 9 JOURNAL AUDIENCE & CALENDARS

Nature Methods provides practical and cutting-edge information on methodological developments, new techniques and crucial tools for scientists working in the fast- nature.com/nmeth paced world of life science research.*

TOPICS: Techniques useful for various aspects of molecular and cellular biology (cell culture, antibody-based techniques, PCR, RNA interference, recombinant DNA, cell signaling studies), and fluorescent and nonfluorescent imaging. Nature Methods also publishes high-profile papers describing genetics and genomics methods (related to sequencing, microarrays, analysis, and manipulation of gene expression), as well as proteomics techniques (including mass spectrometry, protein expression and separation techniques, NMR, and structural genomics approaches).

JOURNAL METRICS * REACH GLOBAL AUDIENCE

Total Cites:...... 45,957 PRINT ** #1 Journal in Biochemical Research Methods 56,724 print circulation

255,799 readership^ W Impact Factor:...... 25.062 o 5-Year Impact Factor:...... 36.723 ONLINE*** 689,427 monthly page views

Immediacy Index:...... 4.672 230,917 monthly unique users A mericas UK/E urope A sia /R Eigenfactor Score:...... 0.21837 Print** 52% 48% 0% Article Influence Score:...... 20.027 EMAIL† 146,237 alert subscribers Online*** 44% 31% 25%

of readers state they are directly average annual budget for 89% involved in purchasing decisions ‡ $77.8K research products/equipment ‡

TOP 5 AREAS OF FOCUS‡ TOP 10 PRODUCTS OR TECHNOLOGIES USED ‡ Biology 66% PCR or RT-PCR 69% Nucleic acid isolation or purification 59% Plant Sciences 24% Molecular biology kits/reagents 64% DNA or RNA sequencing 57% Evolutionary Biology 18% Molecular biology laboratory equipment 64% DNA cloning 54% Mathematical & Computational Biology 13% Electrophoresis 63% Gene expression analysis 49% Agriculture, Dairy & Animal Science 12% Microscopy 60% Protein detection or analysis 45%

JOB TITLES ‡ RESEARCHER PLACE OF WORK ‡ Early-career Scientist/Students 54% University/College 58% VP of Research/Principal Investigator/ Research Institution 25% 21% Lab Director Industry/Corporation 8% Head of Academic Department/ 21% Government 7% Faculty/Professor Hospital 1% CEO/Investor/Business Consultant/ 2%

CALENDAR 2018

TECHNOLOGY FEATURE / READEX RESEARCH / BONUS DISTRIBUTION / PRODUCT FOCUS

• Technology Feature – associate with emerging lab trends • Bonus Distribution - free additional distribution at conferences • Readex Research – receive free audience feedback • Product Focus – inform readers about your relevant products

Materials Product Focus Issue Technology Feature Product Focus Bonus Distribution Ad Close Deadline Deadline

Jan Chemical biology 12-Dec 14-Dec

Genomics, DNA/RNA Feb 8-Jan 10-Jan 8-Jan Readex Research Analysis

255th ACS National Meeting & Exposition (ACS Spring) Mar Microfluidics Mass Spectrometry 7-Feb 9-Feb 15-Feb Analytica

American Association of Cancer Research Annual Apr Cancer Cancer Research 13-Mar 15-Mar 15-Mar Meeting (AACR)

BIO International May PCR Protein Analysis 17-Apr 19-Apr 12-Apr European Society for Human Genetics (ESHG)

Jun Stem cells Microbiology 17-May 21-May 10-May

Jul Model organisms Proteomics 19-Jun 21-Jun 6-Jun

Aug Cell biology PCR 256th ACS National Meeting & Exposition (ACS Fall) 18-Jul 20-Jul 12-Jul

Proteins, Sep Antibodies 20-Aug 22-Aug 16-Aug Readex Research

Oct Genetics Genomics American Society of Human Genetics (ASHG) 18-Sep 20-Sep 18-Sep

Nov Neuroscience Neuroscience Society for Neuroscience (SfN) 17-Oct 19-Oct 25-Sep

Microscopy/ Dec Cell Biology American Society for Cell Biology (ASCB) 15-Nov 19-Nov 1-Nov Imaging

Bonus distribution is subject to change

Media Kit 2018 | Life & Physical Sciences | 11 JOURNAL AUDIENCE & CALENDARS

Nature Biotechnology publishes new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences as well as covers the commercial, political, ethical, legal, and societal aspects of this research.* nature.com/nbt

TOPICS: Analytical biotechnology, applied immunology and vaccines, bioinformatics, bioprocessing, biopharmaceuticals, biosensors and fuel cells, computational biology, chromatography and mass spectrometry, diagnostics, DNA technologies, electrophoresis, enzymes and enzyme engineering, high-throughput screening, intellectual property and legal affairs, molecular engineering, materials science, nucleic acid chemistry, protein engineering, sequencing, statistical tools and software.

JOURNAL METRICS * REACH GLOBAL AUDIENCE

Total Cites:...... 53,992 PRINT** #2 Journal in Biotechnology 10,295 print circulation

& Applied Microbiology 89,951 readership^ W o Impact Factor:...... 41.667 ONLINE*** 5-Year Impact Factor:...... 46.223 802,314 monthly page views Immediacy Index:...... 7.542 309,275 monthly unique users A mericas UK/E urope A sia /R Eigenfactor Score:...... 0.16993 Print** 59% 39% 2% Article Influence Score:...... 23.881 EMAIL† 142,137 alert subscribers Online*** 44% 27% 29%

of readers state they are directly average annual budget for 91% involved in purchasing decisions ‡ $119.3K research products/equipment ‡

TOP 5 AREAS OF FOCUS ‡ TOP 10 PRODUCTS OR TECHNOLOGIES USED ‡ Biotechnology & Applied Microbiology 100% PCR or RT-PCR 82% Molecular biology laboratory equipment 77% Biochemistry & Molecular Biology 74% Cell or tissue culture 78% Microscopy 72% Cell Biology/ Cell Research 59% Molecular biology kits/reagents 77% Protein detection or analysis 71% Biochemical Research Methods 41% Antibody-based techniques 77% Nucleic acid isolation or purification 68% Biomedicine 41% Electrophoresis 77% Protein isolation or purification 62%

JOB TITLES ‡ RESEARCHER PLACE OF WORK ‡ Early-career Scientist/Students 51% University/College 45% VP of Research/Principal Investigator/ Industry/Corporation 30% 28% Lab Director Research Institution 19% Head of Academic Department/ Government 3% Faculty/Professor 10% Hospital 2% CEO/Investor/Business Consultant/ 5% Healthcare Professional/Clinicians 1% Consultant/Fellow/Attending Physician 2%

See the editorial calendar for key dates & topics

Nature Reviews Drug Discovery informs researchers of the science and business within the pharmaceutical and drug research industries.* nature.com/nrdd

TOPICS: Bioinformatics and chemoinformatics, biomarkers, biopharmaceuticals, biotechnology, business development, clinical trials, disease biology, drug delivery, high-throughput screening, licensing, market analysis, medicinal chemistry, ‘omics’ technologies, patent law, pharmacoeconomics, novel therapeutic approaches, pharmacogenetics, pharmacology, rational drug design, regulatory issues, target identification and validation, translational research, toxicology and vaccines.

JOURNAL METRICS * REACH GLOBAL AUDIENCE

Total Cites:...... 28,750 PRINT** #1 Journal in Pharmacology & Pharmacy 7,287 print circulation

46,277 readership^ W Impact Factor:...... 57.000 o 5-Year Impact Factor:...... 49.643 ONLINE*** Immediacy Index:...... 8.474 428,587 monthly page views A mericas UK/E urope A sia /R Eigenfactor Score:...... 0.06082 170,110 monthly unique users Article Influence Score:...... 18.602 Print** 54% 44% 2% EMAIL† 97,011 alert subscribers Online*** 40% 31% 29%

of readers state they are directly average annual budget for 91% involved in purchasing decisions ‡ $110.9K research products/equipment ‡

TOP 5 AREAS OF FOCUS ‡ TOP 10 PRODUCTS OR TECHNOLOGIES USED ‡ Pharmacology & Pharmacy 100% Cell or tissue culture 62% Molecular biology kits/reagents 52% Cell Biology/ Cell Research 52% Antibody-based techniques 59% Electrophoresis 50% Biochemistry & Molecular Biology 51% PCR or RT-PCR 55% Protein detection or analysis 49% Medicine, Research & Experimental 43% Molecular biology laboratory 54% Gene expression analysis 39% Biomedicine 36% Microscopy 54% Flow cytometry or cell sorting 38%

JOB TITLES ‡ RESEARCHER PLACE OF WORK ‡ Early-career Scientist/Students 37% University/College 57% VP of Research/Principal Investigator/ Industry/Corporation 23% 31% Lab Director Research Institution 15% Head of Academic Department/ Government 3% Faculty/Professor 23% Hospital 1% CEO/Investor/Business Consultant/ 3% Healthcare Professional/Clinicians 1% Consultant/Fellow/Attending Physician 1%

See the editorial calendar for key dates & topics

Media Kit 2018 | Life & Physical Sciences | 13 JOURNAL AUDIENCE & CALENDARS

CALENDAR 2018

READEX RESEARCH / BONUS DISTRIBUTION

• Readex Research – receive free audience feedback • Bonus Distribution - free additional distribution at conferences

Issue Special Features / Bonus Distribution Ad Close Materials Deadline

Jan 20-Dec 22-Dec

Feb 17-Jan 19-Jan

Mar Analytica 22-Feb 26-Feb

Apr 27-Mar 29-Mar

May BIO International 24-Apr 26-Apr

Jun 24-May 29-May

Jul Readex 26-Jun 28-Jun

Aug 25-Jul 27-Jul

Sep The MedTech Conference (AdvaMed) 27-Aug 29-Aug

Oct 25-Sep 27-Sep

Nov 24-Oct 26-Oct

Dec 26-Nov 28-Nov

Bonus distribution is subject to change

CALENDAR 2018 READEX RESEARCH / BONUS DISTRIBUTION

• Readex Research – receive free audience feedback • Bonus Distribution - free additional distribution at conferences

Issue Special Features / Bonus Distribution Ad Close Materials Deadline

Jan 8-Dec 12-Dec

Feb 15-Jan 17-Jan

Mar 255th ACS National Meeting & Exposition (ACS Spring) 12-Feb 14-Feb

American Association of Cancer Research Annual Meeting (AACR) Apr 12-Mar 14-Mar Analytica

May 11-Apr 13-Apr

Jun BIO International 11-May 15-May

Jul Readex 12-Jun 14-Jun

Aug 256th ACS National Meeting & Exposition (ACS Fall) 12-Jul 16-Jul

Sep The MedTech Conference (AdvaMed) 13-Aug 15-Aug

Oct 13-Sep 17-Sep

Nov 12-Oct 16-Oct

Dec American Society for Cell Biology (ASCB) 12-Nov 14-Nov

Bonus distribution is subject to change

14 | Life & Physical Sciences | Media Kit 2018 PARTNERSHIPS.NATURE.COM/INFO

Lab Animal is a monthly research journal publishing peer-reviewed articles on methods and technology for improved disease models and enhanced welfare. The journal also nature.com/laban publishes timely and authoritative columns and perspectives on all aspects of lab animal science and animal models of disease.

TOPICS: Animal models, behavioral paradigms, bioinformatics, biology, disease, disease progression, gnotobiotics, microbiome analysis, phenotyping assays/procedures, pre-clinical research, transgenics.

CONTROLLED REACH GLOBAL AUDIENCE CIRCULATION PRINT ** 10,000 print circulation 100% qualified subscribers* 12 issues per year W o ONLINE*** Lab Animal is the only journal in the 10,147 monthly page views

animal research field with a circulation 3,529 monthly unique users A mericas UK/E urope A sia /R verified by the Business Publications EMAIL† Audit (BPA). Print** 100% 0% 0% 1,509 alert subscribers 5,500 third party email Online*** 56% 27% 17% opt-in subscribers

57% of readers state they are directly involved in purchasing decisions ‡

PLACE OF WORK ‡ JOB TITLE ‡ WHAT PRODUCTS DO YOU USE? ‡ Hospital/Animal Hospital 30% Facility Director/Manager/Supervisor 27% Caging/Housing 47% College/University 29% Veterinarian/Pathologist 19% Surgical Equipment 44% Medical School 9% Technician/Technologist 10% Biosafety Equipment 42% Government Research 7% Research Scientist 10% Veterinary Care Equipment 37% Private Research 5% Professor 8% Sterilization Equipment 37% Pharmaceutical Company 4% Research Director/PI 6% Husbandry 37% Contract Research 4% Manager: Regulatory/Compliance/ Enrichment Equipment 34% 6% Biotechnology Company 4% Safety/QA/QC Feeders/Water Systems 33% Consulting Firm 3% Research Assistant/Associate 5% Monitoring Equipment 32% Veterinary School 2% Consultant 3% Specialized Diets 24% Other Industrial Company 1% Toxicologist 1% Antibodies 22% Commercial Breeder 1% Facility Designer: Engineer, Architect 1% Assay Kits 21% Lab Mgmt Software 18%

See the editorial calendar for key dates & topics Contract Services 16% Aquarium/Aquatic Equipment 12%

REGIONAL OPPORTUNITIES Lab Animal is a truly global offering with dedicated regional editions.

EUROPEAN EDITION ASIA PACIFIC EDITION

Europe’s leading publication for scientists, facility managers and technicians Asia’s publication of choice for technologists and scientists at leading research in the Laboratory Animal Science sector in the research industry. establishments, contract research organizations, and educational institutions studying laboratory animal science.

CALENDAR 2018 • Readex Research – receive free audience feedback • Bonus Distribution - free additional distribution at conferences READEX RESEARCH / BONUS DISTRIBUTION / BUYERS’ GUIDE • Buyers’ Guide – product guide of choice for animal researchers

Issue Special Features / Bonus Distribution Ad Close Materials Deadline

Jan 29-Nov 4-Dec

Feb 29-Dec 4-Jan

Mar Society of Toxicology - SOT 7-Feb 9-Feb

Apr 2017 American Association of Cancer Research Annual Meeting - AACR 13-Mar 15-Mar

May 10-Apr 12-Apr

Readex Research Jun 10-May 14-May TriBranch

Jul 12-Jun 14-Jun

Aug 11-Jul 13-Jul

Sep 13-Aug 15-Aug

American Association for Laboratory Animal Science - AALAS Oct 11-Sep 13-Sep Society for Neuroscience 2017 Annual Meeting - SfN

Nov 10-Oct 12-Oct

Dec Buyer’s Guide 8-Nov 12-Nov

Bonus distribution is subject to change

LAB ANIMAL PRODUCT SHOWCASE CALENDAR PROMOTE NEW PRODUCTS AND SERVICES FOR FREE

Issue Date Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

Materials Deadline 22-Nov 22-Dec 31-Jan 6-Mar 3-Apr 3-May 5-Jun 3-Jul 6-Aug 4-Sep 3-Oct 1-Nov

16 | Life & Physical Sciences | Media Kit 2018 SCIENTIFIC DISCIPLINES PARTNERSHIPS.NATURE.COM/INFO

Springer Nature has an impactful portfolio of journals and strong relationships with the world’s top scientific societies that collectively span a broad spectrum of disciplines. This global audience, paired with state-of-the-art advertising technology, makes our vast reach unrivaled, and gives you unprecedented advertising opportunities. We have grouped our journals by subject area to make it easier to identify your audience. You can find key metrics in the A-Z listing at the end of this media kit. Ask your Account Manager for more details.

ASTRONOMY EARTH SCIENCES » Nature Astronomy » Nature Climate Change

» Nature Geoscience

BEHAVIORAL SCIENCES ADDITIONAL JOURNALS: » Nature Human Behaviour npj Climate and Atmospheric Science

BIOMEDICAL SCIENCES ENERGY » Communications Biology » Nature Energy » Lab Animal » Nature Biomedical Engineering ELECTRONICS » Nature Medicine » Nature Electronics » Nature Reviews Cancer ADDITIONAL JOURNALS: » Nature Reviews Disease Primers npj Flexible Electronics » Nature Reviews Drug Discovery

ADDITIONAL JOURNALS: Laboratory Investigation, Modern Pathology ENGINEERING » Nature Biomedical Engineering BIOPHARMA » Nature Biotechnology ENVIRONMENTAL SCIENCES » Nature Chemical Biology » Nature Ecology & Evolution » Nature Medicine » Nature Sustainability » Nature Reviews Drug Discovery ADDITIONAL JOURNALS: npj Clean Water CELLULAR BIOLOGY

» Nature Cell Biology GENETICS » Nature Medicine » Nature Genetics » Nature Reviews Molecular Cell Biology » Nature Reviews Genetics » Nature Structural & Molecular Biology ADDITIONAL JOURNALS: ADDITIONAL JOURNALS: Cancer Gene Therapy, European Journal of Human Genetics, Gene Cell Death & Differentiation, Cell Death & Disease, Cell Death Discovery, Therapy, Genes and Immunity, Genetics in Medicine, Heredity, Human Cell Discovery, Cell Research, Experimental & Molecular Medicine, Genome Variation, Journal of Assisted Reproduction and Genetics, npj Systems Biology and Applications Journal of Genetic Counseling, Journal of Human Genetics, Journal Of Medical Toxicology, npj Genomic Medicine, npj Molecular Phenomics

CHEMISTRY

» Communications Chemistry

» Nature Catalysis

» Nature Chemical Biology » Nature Chemistry

» Nature Reviews Chemistry

ADDITIONAL JOURNALS: Biological Trace Element Research, Journal of The American Society for Mass Spectrometry

Media Kit 2018 | Life & Physical Sciences | 17 SCIENTIFIC DISCIPLINES

IMMUNOLOGY, MICROBIOLOGY MULTIDISCIPLINARY » Nature Immunology » Nature » Nature Medicine » Nature Communications » Nature Microbiology » Scientific Reports

» Nature Reviews Immunology » Scientific Data

» Nature Reviews Microbiology

ADDITIONAL JOURNALS: NEUROLOGY, NEUROSCIENCE Cancer Immunology, Immunotherapy, Cellular & Molecular Immunology, » Nature Medicine Emerging Microbes & Infections, Journal of Clinical Immunology, Microbial Ecology, Microsystems & Nanoengineering, Mucosal » Nature Neuroscience Immunology, npj Biofilms and Microbiomes, npj Vaccines, » Nature Reviews Neuroscience The ISME Journal, The Journal of Antibiotics ADDITIONAL JOURNALS: Molecular Psychiatry, Nature Reviews Neurology, Neuropsychopharmacology, npj Parkinson’s Disease, npj Science of Learning, Spinal Cord, Spinal Cord Series LIFE SCIENCES and Cases, Translational Psychiatry » Nature Ecology & Evolution

ADDITIONAL JOURNALS: Annals of Biomedical Engineering, npj Microgravity, npj Regenerative ONCOLOGY, CANCER RESEARCH Medicine, Signal Transduction & Targeted Therapy » Nature Medicine » Nature Reviews Cancer

ADDITIONAL JOURNALS: MATERIALS SCIENCE Blood Cancer Journal, Bone Marrow Transplantation, Breast Cancer Research » Nature Materials and Treatment, British Journal of Cancer, Leukemia, Cancer Gene Therapy, » Nature Nanotechnology Cancer Immunology, Immunotherapy, Journal of Cancer Survivorship, Journal of Gastrointestinal Cancer, Medical Oncology, Nature Reviews Clinical Oncology, » Nature Reviews Materials npj Breast Cancer, npj Precision Oncology, Oncogene, Oncogenesis, Prostate » NPG Asia Materials Cancer and Prostatic Diseases, Supportive Care in Cancer

Published in association with the Tokyo Institute of Technology PHARMACOLOGY » Nature Reviews Drug Discovery ADDITIONAL JOURNALS: International Journal of Minerals, Metallurgy, and Materials, Metallurgical ADDITIONAL JOURNALS: and Materials Transactions A, Microsystems & Nanoengineering, npj 2D Acta Pharmacologica Sinica, Clinical Pharmacokinetics, Drug Delivery and Materials and Applications, npj Computational Materials,npj Materials Translational Research, Drug Safety, Drugs, Neuropsychopharmacology, Degradation, npj Quantum Materials, Polymer Journal

MEDICINE PHYSICS » Nature Medicine » Communications Physics » Nature Photonics ADDITIONAL JOURNALS: Annals of Surgical Oncology, Canadian Journal of Anesthesia/Journal » Nature Physics canadien d’anesthésie, Cardiovascular, Interventional Radiology, » Nature Reviews Physics Journal of General Internal Medicine, Journal of Nuclear Cardiology, npj Aging & Mechanisms of Disease, npj Digital Medicine, npj Primary Care ADDITIONAL JOURNALS: Respiratory Medicine, Surgical Endoscopy Light: Science and Applications, npj Quantum Information, Polymer Journal, The Mathematical Intelligencer

METHODS, PROTOCOLS

» Nature Methods PLANT SCIENCES » » Nature Protocols Nature Plants ADDITIONAL JOURNALS: Horticulture Research

18 | Life & Physical Sciences | Media Kit 2018 A-Z LISTINGS PARTNERSHIPS.NATURE.COM/INFO

LIFE & PHYSICAL SCIENCES

PRINT* ONLINE** RANKING***

ALERT MONTHLY MONTHLY INDUSTRY PUBLICATION CIRCULATION READERSHIP † SUBSCRIBERS‡ PAGE VIEWS UNIQUE USERS RANK CATEGORY Communications Biology -NEW Online only Online only New New New New New Communications Chemistry -NEW Online only Online only New New New New New Communications Physics -NEW Online only Online only New New New New New Lab Animal 10,000 25,900 1,509 10,147 3,529 81/136 Veterinary Sciences Nature 53,270 412,598 528,229 8,601,421 2,876,265 1/64 Multidisciplinary Sciences Nature Astronomy -NEW Online only Online only 2,714 New New New New Nature Biomedical Engineering -NEW Online only Online only 3,500 New New New New Biotechnology & Applied Nature Biotechnology 10,295 89,951 142,137 802,314 309,275 2/158 Microbiology Nature Catalysis -NEW Online only Online only Launching soon Nature Cell Biology 285 3,009 103,427 392,058 129,882 6/189 Cell Biology Nature Chemical Biology 362 3,449 34,629 287,359 100,283 5/286 Biochemistry, & Molecular Biology Nature Chemistry 636 6,235 39,657 455,190 128,318 4/166 Chemistry, Multidisciplinary Nature Climate Change 471 3,655 36,294 241,672 100,960 1/105 Environmental Studies Nature Communications Online only Online only 51,330 4,258,174 1,121,962 3/64 Multidisciplinary Sciences Nature Ecology & Evolution -NEW Online only Online only 5,477 New New New New Nature Electronics -NEW Online only Online only Launching soon Nature Energy Online only Online only 6,653 127,454 35,685 90/92 Energy & Fuels Nature Genetics 678 7,368 108,378 720,817 258,490 2/166 Genetics & Heredity Nature Geoscience 703 9,056 38,325 234,425 93,567 1/188 Geosciences, Multidisciplinary Nature Human Behaviour -NEW Online only Online only 3,509 New New New New Nature Immunology 654 7,451 82,144 432,978 130,587 4/150 Immunology Nature Materials 493 3,735 101,021 673,658 205,646 1/275 Materials Science, Multidisciplinary Nature Medicine 1,578 14,844 153,982 730,524 280,680 1/128 Medicine, Research & Experimental Nature Methods 56,724 255,799 146,237 689,427 230,917 1/77 Biochemical Research Methods Nature Microbiology Online only Online only 8,460 161,892 58,721 123/124 Microbiology Nature Nanotechnology 395 2,922 54,074 480,772 146,998 1/87 Nanoscience & Nanotechnology Nature Neuroscience 623 6,951 88,418 711,177 228,574 2/258 Neurosciences Nature News Online only Online only 219,406 2,829,621 1,597,618 - - Nature Photonics 498 2,940 29,810 309,130 91,483 1/92 Optics Nature Physics 632 6,126 58,995 323,422 107,230 2/79 Physics, Multidisciplinary Nature Plants Online only Online only 7,533 156,547 42,877 4/211 Plant Sciences Nature Protocols Online only Online only 51,377 510,668 210,543 2/77 Biomedical Research Methods Nature Reviews Cancer 777 3,846 97,179 481,235 174,218 2/217 Oncology Nature Reviews Chemistry -NEW Online only Online only 3,381 New New New New Nature Reviews Disease Primers Online only Online only 3,341 76,378 28,153 13/154 Medicine, General & Pharmacy Nature Reviews Drug Discovery 7,287 46,277 97,011 428,587 170,110 1/256 Pharmacology & Pharmacy Nature Reviews Genetics 469 5,690 96,428 467,126 185,951 1/166 Genetics & Heredity Nature Reviews Immunology 655 6,219 79,545 475,080 166,930 1/150 Immunology Nature Reviews Materials -NEW Online only Online only 4,725 80,402 28,634 New New Nature Reviews Microbiology 377 2,908 66,800 370,109 150,307 1/124 Microbiology Nature Reviews Molecular Cell Biology 273 2,635 112,352 422,525 161,485 1/189 Cell Biology Nature Reviews Neuroscience 490 5,776 85,559 468,559 198,310 1/258 Neurosciences Nature Reviews Physics -NEW Online only Online only Launching soon Nature Structural & Molecular Biology 221 1,853 93,045 244,964 89,897 2/72 Biophysics Nature Sustainability -NEW Online only Online only Launching soon NPG Asia Materials Online only Online only 4,845 46,695 17,785 17/275 Materials Science, Multidisciplinary Scientific American 61,162 - 35,903 10,815,595 6,443,155 27/6 4 Multidisciplinary Sciences Scientific Data Online only Online only 9,877 122,698 50,656 7/6 4 Multidisciplinary Sciences Scientific Reports Online only Online only 96,055 122,698 1,817,239 10/64 Multidisciplinary Sciences Open Access

USA EUROPE Jim Breault Kris Kadel Andrew May US Sales Director Account Executive, West Coast Head of Sales - Europe +1 212 726 9334 +1 212 726-9682 +44 207 843 4785 [email protected] [email protected] [email protected]

Simon Allardice Colleen Osborne Sabine Hugi-Fuerst Senior Account Director Account Executive, East Coast Account Manager, DACH Region +1 415 403 9034 +1 212 451 8713 +41 52 761 33 86 [email protected] [email protected] [email protected]

Kevin Howland David Watson Account Manager, Northeast/Midwest Arcadio Maldonado Account Manager, Europe +1 212 451 8720 Senior Account Executive, Physical Sciences +44 207 843 4959 [email protected] +1 212 451 8525 [email protected] [email protected] Kayte Miller Account Manager, West Coast/Midwest Phil Holtberg + 1 415 403 9038 Account Manager, Lab Animal [email protected] +1 212 847 2547 [email protected] Heather Penn Account Manager, Mid-Atlantic +1 212 726 9668 [email protected]

Jack Laschever Gerard Preston Director of Global Advertising & Sponsorship Director, Global Integrated Advertising +1 212 451 8715 +44 207 843 4965 [email protected] [email protected]

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