Association Between Hyperglycemia and Lipid Profile in Prediabetic and Diabetic Patients

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4th International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS'2013) Oct. 6-7, 2013 Dubai (UAE)

Association between Hyperglycemia and Lipid Profile in Prediabetic and Diabetic Patients

Poorsoltan N*, Ahmadi R, Foroutan M, and Khosravy S

dislipidemia [13]. Dislipidemia is characterized by high Abstract-- Increased blood sugar is a pivotal factor contributing to triglyceride and low HDL cholestrol leves that triglyceride and diabetes and exerts important effects on body biochemistry. The main cholestrol levels in diabetes are more than healthy individuals aim of this study was to determine the effects of increased blood [14]-[19]. High triglyceride level in diabetic patients could be glucose on lipid profile in patients with high fasting blood sugar. more important risk factor for cardiovascular disease in contrast Blood samples of 200 male or female patients with high blood glucose level (100 patients with fasting glucose between 115 and 180 mg/dl, to high LDL cholestrol [20]-[22]. LDL cholestrol level in and 100 patients with fasting blood glucose higher than 180] and, of diabetic women are higher than non-diabetic women. Moreover, 100 male or female subjects with normal fasting blood glucose such relation is not seen in men [23]. (70-115 mg/dl] were biochemically analyzed for serum triglyceride, There are also studies indicating that increased serum levels cholesterol, LDL, HDL and creatinine levels. The normal subjects of glucose can influence enzmes asuch as serum glutamat were correlated with patients with respect to age, sex, diet and habitat. oxsaloacetat transaminase (SGOT), aspartate aminotransferase Data were compared statistically between the groups using one-way (AST), alkaline phosphatase (ALP) and cratine kinase (CK) and analysis of variance. Our findings showed that increased fasting blood change the normal serum levels of such enzymes bringin about sugar can significantly raise the serum level of triglyceride (P<0.01] disturbances in body normal physiology and biochemistry [24] which is partly because of its effects on biochemical pathways involving in converting extra glucose to triglyceride. – [ 34]. The main aim of this study was to determine the effects of Keyword-- Fasting Blood Sugar, Lipid Profile increased blood glucose on lipid profile in patients with increased blood sugar known as prediabetic and diabetic. I. INTRODUCTION II. MATERIAL AND METHODS IABETES is a group of metabolic disease characterized by D hyperglycemia and metabolic changes which could be the A. Participants result of insufficiency or defect in insulin secretion, insulin action or both [1], [2]. In fact, it’s a worldwide prevalence We carried out a retrospective, cross-sectional study. 200 disease with growing trend. According to the studies, diabetes is male or female patients with high blood glucose level (100 the results of interaction between genetical and environmental patients with fasting glucose between 115 and 180 mg/dl (as factors [3]. Among environmental factors, chronic underlying prediabetic), and 100 patients with fasting blood glucose higher disease and inflammation [4], [5], stress and depression [6], [7], than 180 (as diabetic)) and, of 100 male or female subjects with obesity, low physical activity and sedentary lifestyle [8], [9] are normal fasting blood glucose (70-115 mg/dl) were recruited in mentioned. Increased blood sugar is a pivotal factor our study. Patients were admitted to hospitals or medical contributing to diabetes and exerts important effects on body centers. biochemistry and cause complications. Long term B. Blood sample complications of diabetes induced by hyperglycemia are After written informed consent form, blood samples were nephropathy, retinopathy and peripheral and autonomic obtained, then were analyzed biochemically for fasting blood neurapathy which is associated with gastrointestinal [10], glucose and lipid profile. hepatic [11], urinary and cardiovascular disease [12] and C. Statistical Analysis Nooshin Poorsoltan (Msc student) (*corresponding author) is with All values are presented as mean±SEM. Statistical Endocrinology and Metabolism Research Center, Tehran University of significance was evaluated by one-way analysis of variance Medical Sciences, Tehran, Iran (e-mail: [email protected]).. Rahim Ahmadi (PhD) is with the Department of Physiology, Faculty of (ANOVA) using SPSS 19. Differences with P<0.01 were Basic Sciences, Islamic Azad University, Hamedan Branch, Hamedan, Iran. considered significant. (e-mail: [email protected]). Maryam Foroutan (MSc) is with the Department of Biotechnology and III. RESULTS Medical Genetics, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran (e-mail: [email protected]). Table I represents serum triglyceride, cholesterol, HDL and Sepideh Khosravy (MSc) is with the Department of Physiology, Faculty of LDL levels in control, prediabetic and diabetic patients. Basic Sciences, Islamic Azad University, Hamedan Branch, Hamedan, Iran. Statistical analysis suggests that mean serum TG levels in (e-mail: [email protected]). prediabetic and diabetic groups were significantly higher than control group (P<0.01). There was no significant difference in

94 4th International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS'2013) Oct. 6-7, 2013 Dubai (UAE) serum cholesterol, HDL , LDL and creatine levels between ACKNOWLEDGMENT patients and control group. This research has been financially supported by Islamic Azad University-Hamedan Branch. We appreciate all who helped us to exert the present study.

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95 4th International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS'2013) Oct. 6-7, 2013 Dubai (UAE)

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Nooshin Poorslotan. Received her BS degree in Nutrion Science and at present she is MSc student in International Branch of Shahid Beheshti Medical University, Tehran, Iran.

Dr. Rahim Ahmadi. Received his PhD degree in basic physiology and at present he is assistant professor in Islamic Azad University, Hamedan Branch. He is author of more than 30 books and more than 100 scientific papers in local language or in English published in journals or international conference proceedings. He is also senior member of APCBEES.