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Serum Lipid Profile Abnormalities Among Patients with Nephrotic Syndrome

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Serum Lipid Profile Abnormalities Among Patients with Nephrotic Syndrome International Journal of Medicine and Biomedical Research Volume 2 Issue 1 January – April 2013 www.ijmbr.com © Michael Joanna Publications Original Article Serum lipid profile abnormalities among patients with nephrotic syndrome Adu E.M Department of Laboratory Services, Antiretroviral Treatment Centre, Central Hospital, Agbor, Delta State Corresponding author: [email protected] Received: 05.10.12; Accepted: 22.12.12 ABSTRACT Background: Nephrotic syndrome is a multifactorial clinical condition characterized by increased glomerular permeability with consequent massive proteinuria. Hyperlipidaemia has been found to be one of the cardinal manifestations of nephrotic syndrome. Aim: The present study was conducted to determine the lipid profile and cardiovascular risk of nephrotics in this locality. Methods: Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) as well as atherogenic index (AI), coronary risk index (CRI) and non-HDL cholesterol were determined in ninety-six subjects. Forty-eight were nephrotic patients while others were apparently healthy individuals used as controls. Result: TC, TG, and LDL-C of nephrotics was observed to be significantly higher (P<0.05) when compared with control subjects. Similarly, AI, CRI and non-HDL-C of nephrotics were observed to be significantly higher (P<0.05) when compared with control subjects. VLDL-C of both groups was observed to show no significant difference statistically (P>0.05). HDL-C of nephrotics was observed to be significantly lower (P<0.05) when compared with control subjects. Conclusion: The result indicates apparent lipid derangement in nephrotic syndrome which may lead to cardiovascular disease. We therefore recommend that full lipid panel should be included in the investigation of suspected nephrotics to complement early diagnosis of the syndrome and to prevent further complications that could arise from the syndrome. Keywords: Nephrotic syndrome, cardiovascular disease, lipid profile, hyperlipideamia, coronary risk index, atherogenic index INTRODUCTION massive proteinuria. There is a variable tendency towards developing edema, [1] Nephrotic syndrome (NS) is a multi-factorial hypoalbuminemia and hyperlipidaemia. The clinical condition characterized by increased severity of lipid abnormalities also correlates glomerular permeability with consequent with the degree of protienuria and a common Int J Med Biomed Res 2013;2(1):13-17 13 Adu: Lipid profile in nephrotic syndrome complication in patients with chronic kidney METHODOLOGY disease and Nephrotic syndrome is [2] proteinuria>3g/day. The specific causes of Study population nephrotic syndrome include minimal-change Ninety six subjects comprising of forty eight nephropathy, focal glomerulosclerosis, and [1] certified nephrotics based on clinical membranous nephropathy. It can also result manifestation and laboratory findings at the from systemic diseases that affect other Nephrology and Paediatrics Clinic of the organs in addition to the kidneys, such as University of Benin Teaching Hospital (UBTH), diabetes, amyloidosis, and lupus [1] and forty eight apparently healthy individuals erythromatous. without any clinical and laboratory findings of renal dysfunction, hypertension or systemic Hyperlipidaemia is one of the cardinal [3] disease and non-smokers with age and sex- manifestations of nephrotic syndrome. matched as controls were used for the study. Various studies have shown that the Ethical clearance was obtained from the prevalence of hyperlipideamia or dyslipidaemia institution ethical committee and informed in patients with chronic kidney disease is [4] consent was obtained from patients. higher than in the general population. Nephrotics are at an increased risk for Fasting venous blood samples were collected Cardiovascular disease due to the with minimum stasis into plain container. This hyperlipidaemic state. The risk varies was allowed to clot and spun in a centrifuge for depending on the type of lipid abnormalities. 10 minutes. The serum was separated and Studies that reported the lipid profile in kept frozen until required for analysis. nephrotic patients are not consistent. Various authors have reported increased total Biochemical assay cholesterol (TC), low density lipoprotein (LDL), All parameters were assayed using standard very low density lipoprotein (VLDL), methods. total cholesterol,[10] triglycerides,[11] triglycerides (TG) and normal high density HDL-cholesterol,[12] while others are by lipoprotein (HDL) in nephrotics[5-7] but Ohta [8] calculations LDL-cholesterol, VLDL- and his co-worker reported high level of HDL [13] [9] cholesterol, atherogenic index, coronary risk while Alexander and his colleagues reported index[14] and non-HDL-cholesterol (Apo low level of HDL in nephrotic patients. This lipoprotein B surrogate marker).[15] disagreement in data is probably because in Commercially available standard kits (Randox most patients the nephrotic syndrome is Laboratories, U.K) were used. Manufacturer’s accompanied by renal failure or other systemic instructions were strictly adhered to. disorders such as diabetes mellitus (or both), or because the patients are receiving Statistical analysis treatment such as corticosteroids, that has a The mean ± SD was calculated for each confounding effects on the lipoprotein [6] analyte and significant differences between patterns. It has also been shown that the means were determined using the student t- incidence of nephrotic syndrome varies from test. P<0.05 was considered the level of place to place due to factors such as changes significance. in food, habits, climate, type of work, and [1] ethnic origin. Also, certain factors like diet, malnutrition, genetic traits are known to alter RESULTS the frequency and severity of lipid pattern in an individual.[1] Hence, this study sought to The mean ± SD and the statistical comparison determine the lipid pattern of nephrotics in this of serum total cholesterol, triglycerides, HDL- locality and by extension (if any), determine C, LDL-C and VLDL-C are as shown in Table1. the atherogenic index (AI), coronary risk index Table 2 shows the mean±SD of the (CRI) and non-HDL cholesterol a surrogate atherogenic index (AI), coronary risk index marker of Apo-lipoprotein B of these patients. (CRI) and non-HDL-C (Apo lipoprotein B surrogate marker). Figure 1 and 2 shows the mean±SD of total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C and AI,CRI, non-HDL- C in graphical form respectively. Int J Med Biomed Res 2013;2(1):13-17 14 Adu: Lipid profile in nephrotic syndrome Table 1: Serum total cholesterol, triglycerides, HDL-C, LDL-C and VLDL-C (mg/dl) in nephrotics and control subjects PARAMETERS NEPHROTICS CONTROLS P<0.05 (mg/dl) (N=48) (N=48) Total 242±28 190±18 ** Cholesterol Triglycerides 211±30 154±14 ** HDL-C 50±17 102±6.0 ** LDL-C 150±17 57±19 ** VLDL-C 42±6.0 31±3.0 * ** Significant, *not significant Figure 1: Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), very Table 2: Atherogenic index (AI), coronary risk low density lipoprotein (VLDL-C) of nephrotics index (CRI) and non-HDL-C (Surrogate marker and control for Apo lipoprotein B) in nephrotics and controls NEPHROTICS CONTROLS P<0.05 PARAMETERS (N=48) (N=48) (mg/dl) AI 3.0±1.0 0.56±3.2 ** CRI 4.8±1.7 1.9±3.0 ** Non-HDL-C 192±11 88±12 ** (Apo B) (mg/dl) **Significant Our results showed significant increase level of total cholesterol, triglycerides and LDL-C in nephrotic patients when compared with the control. Also, there was an increased level of VLDL-C in nephrotic patients but was not Figure 2: Atherogenic index (AI), coronary risk statistically significant when compared with index (CRI) and non-HDL-C in nephrotics and control. Nephrotic patients showed a control. significantly reduced level of HDL-C when compared with control. The atherogenic and DISCUSSION coronary risk indices as well as Apo lipoprotein B surrogate marker were significantly In our study, we observed increased in nephrotic patients when hypercholesterolemia among nephrotics when compared with control. compared with the control. This is in Int J Med Biomed Res 2013;2(1):13-17 15 Adu: Lipid profile in nephrotic syndrome accordance with the work of various authors[1,5- HDL-C in this study were observed to be 9] who did similar work on nephrotics. Vaziri[3] elevated when compared with the control in his work attributed this hypercholesterolemia subjects. When the AI, CRI and Non-HDL of to a defective regulatory response of 3- our study population were compared with the hydroxy-3-methylglutararyl-coenzyme A guidelines, the nephrotics seem to have (HMG-COA) reductase and hepatic cholesterol unfavorable risk profile for cardiovascular 7α-hydroxylase in nephrotics. These enzymes disease. The recommended ratios for AI and are rate–limiting enzymes in cholesterol CRI is ≤3.5,[14] while the AI observed in the biosynthesis and catabolism to bile acids in study was 3.0±1.0 and 0.56±3.2 for nephrotics humans. There was also an increased level of and control respectively, and CRI on the other triglycerides in nephrotics when compared with hand was 4.8±1.7 and1.9±3.0 for nephrotics control. This is in agreement with the previous and controls respectively. The recommended reports.[5-7] This hypertriglyceridaemia value for non-HDL-C is <130mg/dl,[1,15] observed in nephrotics is attributed to down- nephrotics had a value of 192±11 while control regulation
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