Webb Haymaker Founders of Neurology Archive, 1946-1978
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Recollections of the History of Neuropsychopharmacology Through Interviews Conducted by William E. Bunney, Jr
1 RECOLLECTIONS OF THE HISTORY OF NEUROPSYCHOPHARMACOLOGY THROUGH INTERVIEWS CONDUCTED BY WILLIAM E. BUNNEY, JR. Edited by Peter R. Martin International Network for the History of Neuropsychopharmacology Risskov 2016 2 William E. Bunney, Jr. (circa 1980) 3 Contents PREFACE ..................................................................................................................................................... 4 1. THOMAS A. BAN ............................................................................................................................... 9 2. ARVID CARLSSON .......................................................................................................................... 28 3. JOSEPH T. COYLE ............................................................................................................................ 38 4. ELLEN FRANK ................................................................................................................................. 55 5. J. CHRISTIAN GILLIN ..................................................................................................................... 66 6. LOUIS A. GOTTSCHALK ................................................................................................................ 78 7. SALOMON Z. LANGER ................................................................................................................... 89 8. HEINZ E. LEHMANN .................................................................................................................... -
EPILEPSY and Eegs in BOSTON, BEGINNING at BOSTON CITY HOSPITAL
EPILEPSY AND EEGs IN BOSTON, BEGINNING AT BOSTON CITY HOSPITAL Frank W. Drislane, MD Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA Early Neurology at Harvard Medical School: In the 1920s and 1930s: Neurology and Psychiatry were largely one field. “All practitioners of the specialty [Neurology] were neuropsychiatrists” -- Merritt: History of Neurology (1975) 1923: David Edsall, first full-time Dean at Harvard Medical School “creates a Department of Neurology to build on the fame of James Jackson Putnam” [1] 1928: Harvard, Penn, and Montefiore-Columbia were the only Neurology departments in the US. 1930: The Harvard Medical School Neurology service at Boston City Hospital, one of the first training centers in the US, founded by Stanley Cobb 1935: American Board of Psychiatry and Neurology 1936: “There were only 16 hospitals listed in the United States a having approved training for residency in Neurology.” [1] 1947: There are 32 Neurology residency positions in the US 1948: Founding of the American Academy of Neurology Stanley Cobb (1887 – 1968) 1887: Brahmin, born in Boston. Speech impediment. 1914: Harvard Medical School grad, after Harvard College Studied Physiology at Hopkins 1919: Physiology research with Walter B Cannon and Alexander Forbes at Harvard 1925: Appointed Bullard Professor of Neuropathology at Harvard Medical School {Successors: Raymond Adams, E Pierson Richardson, Joseph Martin} Interested in Neurology and Psychiatry, and particularly, epilepsy and its relation to cerebral blood flow 1925: Starts the Neurology program at Boston City Hospital (with financial support from Abraham Flexner) Faculty include: Harold Wolff (headaches; cerebral circulation; founder of Cornell Neurology Department), Paul Yakovlev, Sam Epstein Cobb’s Neuropathology group at the HMS medical school campus includes William Lennox 1928: Cobb hires Tracy Putnam for a research position in the Neurosurgery division; Houston Merritt arrives as a resident © 2017 The American Academy of Neurology Institute. -
Women Members of the Academies of Science - a Comparative Study with Special Consideration of the Kaiser Wilhelm Society from 1912 Until 1945
Women Members of the Academies of Science - A comparative study with special consideration of the Kaiser Wilhelm Society from 1912 until 1945. Annette Vogt (Berlin)1 On June 20, 1948 the physicist Lise Meitner (1878-1968) wrote to her younger colleague Berta Karlik (1904-1990) in Vienna after her election - as its first woman - to the Austrian Academy of Science: "Liebe Kollegin Karlik, ... Wenn meine Wahl zum korrespondierenden Mitglied der Wienerakademie diese Möglichkeit auch für andere Frauen eröffnet, so macht sie mich doppelt froh. Ich habe mich über diese Auszeichnung aufrichtig gefreut, alles was ein Band mit Österreich knüpft, gibt mir ein inneres Heimatgefühl, das ich trotz aller Freundlichkeit der Schweden (ich bin z. B. Mitglied aller 4 skandinavischen Akademien) hier nicht bekommen kann, weil ich zu alt war, als ich hierher kam, um mich ganz einzuleben."2 Lise Meitner was one of the most exceptional women scientists in the 20th century and belonged - mostly as their first woman member - (as Scientific 1 Lecture (17.6.00) on the International conference "The work of science", Berlin- Brandenburgische Akademie der Wissenschaften (BBAW), Berlin, 15.-17.6.2000. Thanks to Emma Spary (Cambridge) from the MPI for History of Science for her kindness to correcting my English. 2 Lise Meitner to Berta Karlik, 20.6.1948, in: Cambridge, Churchill College Archives, Meitner-Papers, MTNR 5/10, folder 2, Bl.11. ("Dear colleague Karlik, ... If my election as a corresponding member of the Academie in Vienna will open this possibility for other women scientists too then I would be doubly happy. I was delighted with this honor, every relation to Austria gives me a home feeling which I haven't here in spite of the kindness of the Swedes (for example I'm a member of all 4 Scandinavian Academies of Science), because I was too old when I came here to settle down completely.") Berta Karlik followed Lise Meitner indeed, becoming a corresponding member in 1954 and a full member in 1973 at the ÖAW in Vienna. -
Evaluating and Controlling Glioblastoma Infiltration by Joseph
Evaluating and Controlling Glioblastoma Infiltration by Joseph F. Georges A Dissertation Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Approved March 2014 by the Graduate Supervisory Committee: Burt Feuerstein, Co-Chair Brian Smith, Co-Chair Kendall Van Keuren-Jensen Pierre Deviche Kevin Bennett ARIZONA STATE UNIVERSITY May 2014 ABSTRACT Glioblastoma (GBM) is the most common primary brain tumor with an incidence of approximately 11,000 Americans. Despite decades of research, average survival for GBM patients is a modest 15 months. Increasing the extent of GBM resection increases patient survival. However, extending neurosurgical margins also threatens the removal of eloquent brain. For this reason, the infiltrative nature of GBM is an obstacle to its complete resection. The central hypothesis of this dissertation is that targeting genes and proteins that regulate GBM motility, and developing techniques that safely enhance extent of surgical resection, will improve GBM patient survival by decreasing infiltration into eloquent brain regions and enhancing tumor cytoreduction during surgery. Chapter 2 of this dissertation describes a gene and protein; aquaporin-1 (aqp1) that enhances infiltration of GBM. In chapter 3, a method is developed for enhancing the diagnostic yield of GBM patient biopsies which will assist in identifying future molecular targets for GBM therapies. In chapter 4, an intraoperative optical imaging technique is developed for improving identification of GBM and its infiltrative margins during surgical resection. This dissertation aims to target glioblastoma infiltration from molecular and cellular biology and neurosurgical disciplines. In the introduction; 1. A background of GBM and current therapies is provided. 2. -
Percival Bailey and the Classification of Brain Tumors
Neurosurg Focus 18 (4):E7, 2005 Percival Bailey and the classification of brain tumors SHERISE FERGUSON, M.A., AND MACIEJ S. LESNIAK, M.D. Division of Neurosurgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois Throughout his illustrious career, Percival Bailey made numerous contributions to the fields of neurology, neu- roanatomy, psychiatry, neuropathology, and, of course, neurosurgery. His expertise, his curiosity about the nervous system, and his desire to examine it from all angles were unique. With the exception of Harvey Cushing, Dr. Bailey made some of the greatest contributions in the area of neuro-oncology at the turn of the last century. In this essay the authors summarize the key episodes of Bailey’s life and discuss his impact on the classification and treatment of human brain tumors. KEY WORDS • Percival Bailey • brain tumor • meningioma • glioma • tumor classification • neurosurgical history Percival Bailey was born in 1892 in the southernmost routine dissection of the pituitary, Bailey unintention- part of Illinois, a rural area known as “Little Egypt.” He ally damaged the infundibular artery. At the time, Bailey spoke warmly of his memories of childhood and growing thought his mistake was an incredible blunder. Neverthe- up in this small town in his autobiography, Up from Little less, the next morning he found a large pool of urine on Egypt.8 Bailey’s early education took place in a one-room the floor next to the dog. To his surprise, he realized that schoolhouse and then at Southern Illinois Normal Univer- he had produced polyuria without exposing the pituitary sity. -
Neuroscience in Nazi Europe Part II: Resistance Against the Third Reich Lawrence A
HISTORICAL REVIEW Neuroscience in Nazi Europe Part II: Resistance against the Third Reich Lawrence A. Zeidman ABSTRACT: Previously, I mentioned that not all neuroscientists collaborated with the Nazis, who from 1933 to 1945 tried to eliminate neurologic and psychiatric disease from the gene pool. Oskar and Cécile Vogt openly resisted and courageous ly protested against the Nazi regime and its policies, and have been discussed previously in the neurology literature. Here I discuss Alexander Mitscherlich, Haakon Saethre, Walther Spielmeyer, Jules Tinel, and Johannes Pompe. Other neuroscientists had ambivalent roles, including Hans Creutzfeldt, who has been discussed previously. Here, I discuss Max Nonne, Karl Bonhoeffer, and Oswald Bumke. The neuroscientists who resisted had different backgrounds and moti vations that likely influenced their behavior, but this group undoubtedly saved lives of colleagues, friends, and patients, or at least prevented forced sterilizations. By recognizing and understanding the actions of these heroes of neuroscience, we pay homage and realize how ethics and morals do not need to be compromised even in dark times. RÉSUMÉ: Neuroscience en Europe sous domination nazie, 2e partie : résistance contre le Troisième Reich. J’ai mentionné antéri eurement que tous les neuroscientifiques n’avaient pas collaboré avec les nazis qui, de 1933 à 1945, ont tenté d’éliminer la maladie neurologique et psychiatrique du patrimoine génétique. Oskar et Cécile Vogt se sont opposés ouvertement et ont protesté courageusement contre le régime nazi et ses politiques. Ce sujet a déjà été exposé dans la littérature neurologique. Je discute ici d’Alexander Mitscherlich, de Haakon Saethre, de Walther Spielmeyer, de Jules Tinel et de Johannes Pompe. -
Außenseiter: Cécile Und Oskar Vogts Hirnforschung Um 1900 Satzinger, Helga 2011
Repositorium für die Geschlechterforschung Außenseiter: Cécile und Oskar Vogts Hirnforschung um 1900 Satzinger, Helga 2011 https://doi.org/10.25595/241 Veröffentlichungsversion / published version Sammelbandbeitrag / collection article Empfohlene Zitierung / Suggested Citation: Satzinger, Helga: Außenseiter: Cécile und Oskar Vogts Hirnforschung um 1900, in: Bleker, Johanna; Hulverscheidt, Marion; Lenning, Petra (Hrsg.): Visiten. Berliner Impulse zur Entwicklung der modernen Medizin (Berlin: Kulturverlag Kadmos, 2011), 179-195. DOI: https://doi.org/10.25595/241. Nutzungsbedingungen: Terms of use: Dieser Text wird unter einer CC BY 4.0 Lizenz (Namensnennung) This document is made available under a CC BY 4.0 License zur Verfügung gestellt. Nähere Auskünfte zu dieser Lizenz finden (Attribution). For more information see: Sie hier: https://creativecommons.org/licenses/by/4.0/deed.en https://creativecommons.org/licenses/by/4.0/deed.de www.genderopen.de Johanna Bleker, Marion Hulverscheidt, Petra Lennig (Hg.) Visiten Berliner Impulse zur Entwicklung der modernen Medizin Mit Beiträgen von Thomas Beddies, Johanna Bleker, Gottfried Bogusch, Miriam Eilers, Christoph Gradmann, Rainer Herrn, Petra Lennig, Ilona Marz, Helga Satzinger, Heinz-Peter Schmiedebach und Thomas Schnalke Kulturverlag Kadmos Berlin Inhalt Vorwort . 7 Einleitung . 9 Auf dem Weg zur naturwissenschaftlichen Medizin 1810–1870 Heinz-Peter Schmiedebach Grenzverschiebungen. Zur Berliner Psychiatrie im 19. Jahrhundert................ 19 Ilona Marz Stiefkind der Medizin? Die Anfänge der akademischen Zahnheilkunde in Berlin ............................... 37 Petra Lennig Benötigen Ärzte Philosophie? Die Diskussion um das Philosophicum 1825−1861 . 55 Gottfried Bogusch Wissenschaftler, Lehrer, Sammler. Der erste Berliner Universitätsanatom Karl Asmund Rudolphi.. 73 Johanna Bleker »Schönlein ist angekommen!« Der Begründer der klinischen Methode in Berlin 1840−1859.................. 89 Thomas Schnalke Die Zellenfrage. -
E2017287.Pdf (92.90Kb)
TODAY'S NEUROSCIENCE, TOMORROW'S HISTORY A Video Archive Project Dr Ann Silver Interviewed by Richard Thomas Supported by the Wellcome Trust, Grant no:080160/Z/06/Z to Dr Tilli Tansey (Wellcome Trust Centre for the History of Medicine, UCL) and Professor Leslie Iversen (Department of Pharmacology, University of Oxford) Interview transcript Edinburgh University, BSc (Hons) 1954, PhD 1960 – physiology and the construction of Henrietta I’d always been interested in sort of zoological things, having grown up in the country. My brother did zoology, but you had to do three subjects in your first year, and then you specialised after that. And I was going to do zoology – I didn’t know what I was going to do with it in my second year – but Ruth Fowler, who is now Bob Edwards’ wife, wanted to do physiology. And I’d really hardly heard of physiology, and she wanted me to go along and see Catherine Hebb who was running the course for science students as opposed to medical students. So I went along and immediately took to the idea of doing physiology. My honours year was actually interrupted by having to have spinal fusion, which was rather new in those days, and didn’t work very well. And so I, actually, more or less missed a year, and so I actually took five years rather than four years to complete my degree. And then, by that time - by the time I had finished - Catherine Hebb had moved down to the … what was then the Agricultural Research Council Institute of Animal Physiology at Babraham (Cambridgeshire), where Daly had moved from Edinburgh to be its first director. -
Tumor Heterogeneity in Glioblastomas: from Light Microscopy to Molecular Pathology
cancers Review Tumor Heterogeneity in Glioblastomas: From Light Microscopy to Molecular Pathology Aline P. Becker 1,* , Blake E. Sells 2 , S. Jaharul Haque 1 and Arnab Chakravarti 1 1 Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA; [email protected] (S.J.H.); [email protected] (A.C.) 2 Medical Scientist Training Program, Washington University in St. Louis, St. Louis, MO 63310, USA; [email protected] * Correspondence: [email protected] Simple Summary: Glioblastomas (GBMs) are the most frequent and aggressive malignant tumors arising in the human brain. One of the main reasons for GBM aggressiveness is its diverse cellular composition, comprised by differentiated tumor cells, tumor stem cells, cells from the blood vessels, and inflammatory cells, which simultaneously affect multiple cellular functions involved in cancer development. “Tumor Heterogeneity” usually encompasses both inter-tumor heterogeneity, differ- ences observed at population level; and intra-tumor heterogeneity, differences among cells within individual tumors, which directly affect outcomes and response to treatment. In this review, we briefly describe the evolution of GBM classification yielded from inter-tumor heterogeneity studies and discuss how the technological development allows for the characterization of intra-tumor hetero- geneity, beginning with differences based on histopathological features of GBM until the molecular alterations in DNA, RNA, and proteins observed at individual cells. Citation: Becker, A.P.; Sells, B.E.; Abstract: One of the main reasons for the aggressive behavior of glioblastoma (GBM) is its intrinsic Haque, S.J.; Chakravarti, A. Tumor intra-tumor heterogeneity, characterized by the presence of clonal and subclonal differentiated tumor Heterogeneity in Glioblastomas: cell populations, glioma stem cells, and components of the tumor microenvironment, which affect From Light Microscopy to Molecular multiple hallmark cellular functions in cancer. -
Oskar Vogt: the First Myeloarchitectonic Map Of
Communication • DOI: 10.2478/v10134-010-0005-z • Translational Neuroscience • 1(1) • 2010 • 72–94 Translational Neuroscience OSKAR VOGT: THE FIRST MYELOARCHITECTONIC MAP OF Miloš Judaš1 THE HUMAN FRONTAL CORTEX Maja Cepanec1,2 Abstract 1University of Zagreb School of The aim of this paper is threefold: (a) to provide the translation in English of Oskar Vogt’s seminal 1910 paper Medicine, Croatian Institute for Brain describing the first myeloarchitectonic map of the human frontal cortex, introduced by a brief historical review Research, Šalata 12, 10000 Zagreb, of Cécile & Oskar Vogt’s contribution to neuroscience; (b) to provide an annotated bibliography of major works of Croatia cortical cytoarchitectonics and myeloarchitectonics in the tradition of the Brodmann-Vogt architectonic school 2University of Zagreb, Faculty of (Supplement 2); and (c) to provide an annotated bibliography of major works of the Russian architectonic school Education and Rehabilitation Sciences, Department of Speech and which was founded by Oskar Vogt (Supplement 3). Language Pathology, Developmental Neurolinguistics Lab, 10000 Zagreb, Keywords Croatia Brodmann-Vogt architectonic school • cytoarchictonics • myeloarchitectonics cerebral cortex • Russian architectonic school • history of neuroscience Received 04 March 2010 © Versita Sp. z o.o. Accepted 20 March 2010 1. Introduction (the chief of the university psychiatric clinic) In the Spruce Mountains (Fichtelbirge) who firmly believed that mental disorders had region, there was an exclusive resort called Cécile and Oskar Vogt were pioneers of an anatomical basis. Oskar Vogt graduated as Alexandersbad, and in the summer of 1896 modern neuroscience who opened new a physician in 1893, and in 1894 obtained his Vogt accepted position there as a physician horizons and pointed to directions for future doctorate in medicine from Jena University, to (Kurarzt). -
Nikolay Vladimirovich Timofeeff-Ressovsky (1900-1981
Copyright 2001 by the Genetics Society of America Perspectives Anecdotal, Historical and Critical Commentaries on Genetics Edited by James F. Crow and William F. Dove Nikolay Vladimirovich Timofeeff-Ressovsky (1900±1981): Twin of the Century of Genetics Vadim A. Ratner Institute of Cytology & Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia Don't treat science with savage seriousness. N. V. Timofeeff-Ressovsky ikolay Vladimirovich Timofeeff-Ressovsky born Moscow University, participated in various intellectual N September 7, 1900, would now be 100 years old. circles, sang as a ®rst bass in the Moscow military chorus, He was of the same age as the ªCentury of Genetics.º was a load-carrying worker, and ®nished Moscow Univer- This is especially notable now, at the border between sity in 1922. Later he talked about this grim period two millennia, ªa time to cast away stones, and a time (Timofeeff-Ressovsky 2000, p. 106): ªI think, never- to gather stones together.º It is remarkable that the theless, that all in all the life was merry±very few hungry, personality and fate of Nikolay V. Timofeeff-Ressovsky, very few frozen. Rather, people were young, healthy, N.V., re¯ect the most crucial, tragic, and dramatic events and vigorous.º of the century. In 1922 N.V. began his work as a scientist at the Insti- N. V.'s roots were in the nineteenth century, in Rus- tute of Experimental Biology with Professor N. K. Kolt- sian history and classics. His genealogy is living Russian sov. Nikolay Konstantinovich Koltsov was an outstanding history: It contains the Cossaks of the legendary Cossak ®gure in Russian biological science. -
In Retrospect: Brodmann's Brain
OPINION NATURE|Vol 461|15 October 2009 In Retrospect: Brodmann’s brain map A classic neurology text written 100 years ago still provides the core principles for linking the anatomy of the cerebral cortex to its functions today, explains Jacopo Annese. Localisation in the Cerebral Cortex Using a microscope designed for the purpose, discuss these towards the end. Some of his by Korbinian Brodmann he undertook meticulous examinations of peers were more forthright about labelling First published 1909 (in German). cortical tissue from the brains of humans and cortical regions according to function, notably many other mammals, the results of which the Australian-born neurologist A. W. Camp- enabled him to construct his map of the human bell, who used clinical evidence with results The development of advanced magnetic cortex. The map looks simple, yet the book from physiological experiments and anatomi- resonance imaging techniques over the past makes it clear it is based on a monumental cal analysis to make his case. Still, Brodmann’s 30 years has heralded today’s ‘golden age’ of analytical effort. His exquisite powers of obser- objective approach has ensured that his maps human brain mapping. Yet in the quest to chart vation and great attention to detail transform have endured, eclipsing others of the time such structural and functional subdivisions in the for the reader the tedium of scientific annota- as Campbell’s. brain, and in the cerebral cortex in particular, tion into an exercise in anatomical voyeurism. Another of Brodmann’s long-lasting the first quarter of the twentieth century was achievements documented in the book is his at least as momentous.