Anti-SETMAR (full length) polyclonal (DPABH-06532) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Histone methyltransferase that methylates Lys-4 and Lys-36 of , 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 Lys-36. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.

Immunogen Recombinant full length protein, corresponding to amino acids 1-352 of Human SETMAR (AAH11635.1; UniProt Q53H47-2).

Isotype IgG

Source/Host Mouse

Species Reactivity Human

Purification Protein A purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 50 μg

Buffer pH: 7.20; Constituent: 99% PBS

Preservative None

Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

GENE INFORMATION

Gene Name SETMAR SET domain and mariner fusion gene [ Homo sapiens ]

Official Symbol SETMAR

Synonyms SETMAR; SET domain and mariner transposase fusion gene; histone-lysine N-

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved methyltransferase SETMAR; metnase; hsMar1; SET domain and mariner transposase fusion gene-containing protein; METNASE;

Entrez Gene ID 6419

Protein Refseq NP_001230652

UniProt ID Q53H47

Chromosome Location 3p26.2

Pathway Lysine degradation;

Function endonuclease activity; histone-lysine N-methyltransferase activity; hydrolase activity; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved