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Bruker AXS 3 Year Warranty on IµS X8 PROSPECTOR High Performance, Low Maintenance The X8 PROSPECTOR is an exceptionally low maintenance x-ray system designed to simplify crystal screening and data collection. The X8 PROSPECTOR has the reli- ability, speed and performance to make any structural biology lab more productive. Ultra-reliable IµS source with QUAZAR MX optics for a surprisingly high intensity Taperless CCD for ultimate detector sensitivity and speed Low maintenance, low cost of ownership - air-cooled source Crystallography think forward www.bruker-axs.com American Crystallographic Association The cover image was adapted from a slide shown by Gerald Stubbs in session 7.09 Fibril-forming Pathological Pep- ACA RefleXions tides: Prions, Amyloids & "Friends". Fall, 2010 See page 8 for a more complete description. ACA HOME PAGE: www.AmerCrystalAssn.org Table of Contents 3 President’s Column 5 Highlights of Council meetings in Chicago 6-8 Awards & News 8 On the Cover 9-11 Dick van der Helm (1933-2010) 12-15 David H. Templeton (1920-2010) 15 Lachlan M. D. Cranswick (1969-2010) 16 Lodovico Riva Di Sanseverino (1939-2010) 17 Gordon Smith (1928-2010) 17 Contributors to this issue 18 Late-breaking news; calls for award nominations, nominations for ACA offices in 2012; summer school proposals; pleas for Opinion column volunteer and for Art in Crystallography entries. 19-57 2010 ACA meeting in Chicago: poster awards; photos of attendees, reports from session chairs, and images the speakers used in their talks. 38 Index of advertisers 59 Corporate Members 61 ISC 2010 in Granada 63 2011 ACA meeting in New Orleans 64 Calendar of Meetings Contributions to ACA RefleXions may be sent to either of the Editors: Please address matters pertaining to advertisements, membership inquiries, or use of the ACA mailing list to: Connie (Chidester) Rajnak ......................... Judith L. Flippen-Anderson 4210 Old Field Trail .............................................. 3521 Launcelot Way Marcia J. Colquhoun, Director of Administrative Services Kalamazoo, MI 49008 ........................................ Annandale, VA 22003 American Crystallographic Association P.O. Box 96, Ellicott Station tel. 269-342-1600 ....................................................tel. 703-346-2441 Buffalo, NY 14205 [email protected]... [email protected] tel: 716-898-8692; fax: 716-898-8695 [email protected] Deadlines for contributions are: February 1 (Spring), May 1 (Summer), August 1 (Fall) and November 1 (Winter) ACA RefleXions (ISSN 1058-9945) Number 3 2010. Published four times per year in the spring, summer, fall and winter for the membership of the American Crystallographic Association, P.O. Box 96, Ellicott Station, Buffalo, NY 14205-0096. Membership in the ACA includes a non-deductible charge of $1.75 from membership dues to be applied to a subscription to the ACA Newsletter. Periodicals postage paid at Buffalo, New York. POST- MASTER: Send address changes to ACA, P.O.Box 96, Ellicott Station, Buffalo, NY, 14205-0096. President's Column Fall 2010 When I ran for the Vice- IUCr President Sine Larsen attended our meeting again this Presidency of the ACA, no year. Sine reported that the IUCr is leading an effort to get 2013 one told me how much fun officially designed by UNESCO and the United Nations as the this whirlwind was going International Year of Crystallography. This would coincide to be. Here we are, just nicely with the centennial celebrations of the Laue (2012) and days back from our annual Bragg (2013) experiments. The ACA and the USNCCr have meeting in Chicago, and enthusiastically endorsed this effort. People interested in being our RefleXions Editors are involved or with ideas should contact an ACA council member. already getting reports in As an aside, the IUCr is urging all crystallographers to update from Session Chairs. There their entries in the World Directory of Crystallographers. is a lot about our 2010 Fred Dylla, Executive Director and CEO of the American Insti- meeting to celebrate. Those tute of Physics, also came to Chicago and met with the ACA of you who were able to Council so that we could discuss the benefits the ACA receives be in Chicago know how from AIP membership and the extensive support services that good the meeting was, and AIP can provide to the ACA. The ACA has been a member of we owe a great deal to Ross Angel, the 2010 Program Chair, AIP since 1966. and Bernie Santarsiero, the 2010 Local Chair, and their teams. However, many of you might not know how successful it was Proposals for 2011 summer schools are in hand, promising an in a number of respects. Torrential rains overnight on Friday exciting roster of options for next year, including small molecule closed O’Hare for a time and flooded roads to the extent that and macromolecular oriented summer schools. A Call for 2012 three giant carp made their way to Roosevelt Road via a storm Summer Schools is in this issue with a deadline for proposal drain, causing a unique traffic jam. In spite of this, only a few submission of January 15, 2011. Members of the Continuing people were unable to make it to the Saturday workshops. Those Education Committee and Marcia Colquhoun are happy to that did slog their way to the on and off-site venues found the receive inquiries and provide guidance to people considering workshops stimulating and fruitful. This was especially true of organizing a summer school. So, if you have an idea for a the high school teacher workshop, which had been funded by the Summer School that you would like to try out, now is the time. National Science Foundation through a grant to Cora Lind and On a serious financial note, the ACA has experienced signifi- by the USNCCr. The skillful presenters quickly overcame the cant increases in meeting expenses over the years (about 50 intimidation factor that CRYSTALLOGRAPHY can engender percent from 2003 to the projected cost/attendee for 2011). when first encountered, and got the participants involved in the These include increased A/V costs, telecommunications, credit fun of symmetry, packing, and molecular structures. Summaries card processing fees, coffee break expenses, etc. In addition, of the scientific sessions can be found in this issue; the workshop our meeting sponsorships decreased by 50 percent this year. reports will be in the winter issue. As we presented at the Chicago Business Meeting, the Finance With 621 abstracts and 963 attendees, this meeting was among Committee recommended and the ACA Council approve a 10 our very biggest. Two special guests attended, Carol Delbaere percent increase in the membership dues (from $100 to $110 for and Margaret Churchill, widows of Louis Delbaere and Bob regular membership) and meeting registration fees (from $450 Bau, respectively. They made our memorial sessions for Louis to $500 for regular registration). These increases will take place and Bob even more special by joining in our meeting. Margaret in 2011. Late abstract fees will rise from $100 to $150. This graciously endowed a new triennial award, the Bau Neutron decision was not made lightly, and we trust you will appreci- Diffraction Award that will recognize exceptional research ate the need to keep the ACA solvent while bringing you the achievement in neutron diffraction. The award will be given for benefits and services that the membership deserves and expects. the first time in 2013 and will be coordinated by Tom Koetzle, Looking ahead to Boston in 2012, we will present the Buerger, Bob’s long-time friend and colleague. We were also honored to Warren, Supper and Etter awards. The calls for nominations have Mayor Daley’s Commissioner of Public Health, Bechara for these awards have a due date of April 2, 2011, (see the Choucair, join us at the banquet, where he gave us official words summer RefleXions, p 28). Please give thought to who might of welcome and an invitation to come back to Chicago any time. be outstanding candidates for these awards, and submit your marcia@ As they have for the last twenty years, AIP provided exhibits nominations for these awards to Marcia Colquhoun ( hwi.buffalo.edu management services for our Chicago meeting. Over those two ). decades, the ACA Exhibit has grown in size and scope, and The Nominations Committee for the 2012 ACA offices of Vice we are looking for more growth in 2011 in New Orleans. In an President, Secretary and Standing Committee Members has attempt to better serve our membership, we had survey forms been formed and is made up of Marv Hackert, Bob von Dreele, in Chicago that asked for membership input on expanding the and Gerald Stubbs. Please forward the names of any suggested range of vendors at our annual meetings. We will have the space candidates to them. Also, please remember to vote for the 2011 in New Orleans to add booths, so if you would like to see more officers by November 15th. microscopes, or powder mills, or peptide synthesis/sequencing Jen Shepard served recently as our ACA Web Manager and equipment, or whatever, now is your chance to let us know what Membership Secretary, but she left the Buffalo office of the ACA would be useful to you. 3 Bruker AXS 3 Year Warranty on IµS APEX DUO - Dual Wavelength Perfected The Most Versatile System for Small Molecule Crystallography The APEX DUO combines the highest intensity Microfocus sealed tube sources for Mo and Cu radiation with the most sensitive CCD detector for crystallography. The APEX DUO allows collection of charge density quality data with Mo radiation and exploits all the advantages of Cu wavelength for absolute structure determination and diffraction experiments on ever smaller organic crystals. 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  • Evolutionary Tinkering with Transposable Elements

    Evolutionary Tinkering with Transposable Elements

    COMMENTARY Evolutionary tinkering with transposable elements I. King Jordan* National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894 t was almost 30 years ago when with to create novel forms. Indeed, de- Franc¸oisJacob declared that evolu- spite the early notion of TEs as being tionary innovation (the emergence strictly selfish (parasitic) elements that of novel form and function over serve no function for their hosts (7), Itime) occurred primarily via a process there now exist numerous examples of of ‘‘tinkering’’ (1). By tinkering, Jacob formerly mobile TE sequences that have essentially meant the creation of novelty been ‘‘domesticated’’ (8) to serve some through random combinations of pre- functional role for the host genomes in existing forms. Two fundamental and which they reside (9, 10). However, countervailing notions are implicit in there is still a relative paucity of de- this view of evolution: optimality versus tailed studies that address both the evo- constraint. Were evolution to perform lutionary dynamics of TE-derived host optimally, a more apt metaphor might genes as well as the functional roles of be that of an engineer. An engineer the proteins that they encode. The work works according to a plan, with a pre- of Cordaux et al. (3) on the SETMAR cise goal for the desired end, and uses gene represents an important step to- material designed specifically toward ward alleviating this knowledge gap. that end. Evolution, on the other hand, SETMAR, originally discovered by must work without the benefit of fore- Robertson and Zumpano (11), is a chi- sight and is subject to very real con- meric gene made up of a SET histone straints with respect to the material at methyltransferase transcript fused to the its disposal; as such, evolutionary biol- transposase domain of a formerly mo- ogy is replete with examples of subopti- bile TE sequence.