Product Datasheet

SETMAR

Catalog No: #43086

Orders: [email protected] Description Support: [email protected]

Product Name SETMAR Antibody

Host Species Rabbit

Clonality Polyclonal

Purification Antigen affinity purification.

Applications WB IHC

Species Reactivity Hu

Specificity The antibody detects endogenous levels of total SETMAR protein.

Immunogen Type protein

Immunogen Description Fusion protein of human SETMAR

Target Name SETMAR

Other Names Mar1; HsMar1; METNASE

Accession No. Swiss-Prot#: Q53H47Gene ID: 6419

Calculated MW 78kd

Concentration 1mg/ml

Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage Store at -20°C

Application Details

Western blotting: 1:200-1:1000

Immunohistochemistry: 1:20-1:100

Images

Gel: 6%SDS-PAGE Lysate: 40 µg Lane: Jurkat cell Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 30 seconds

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #43086 at dilution 1/20.

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #43086 at dilution 1/20.

Background

This encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain.

Note: This product is for in vitro research use only and is not intended for use in humans or animals.

Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2