Anti-SETMAR (full length) polyclonal antibody (DPABH-06532) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 Lys-36. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. Immunogen Recombinant full length protein, corresponding to amino acids 1-352 of Human SETMAR (AAH11635.1; UniProt Q53H47-2). Isotype IgG Source/Host Mouse Species Reactivity Human Purification Protein A purified Conjugate Unconjugated Applications WB Format Liquid Size 50 μg Buffer pH: 7.20; Constituent: 99% PBS Preservative None Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. GENE INFORMATION Gene Name SETMAR SET domain and mariner transposase fusion gene [ Homo sapiens ] Official Symbol SETMAR Synonyms SETMAR; SET domain and mariner transposase fusion gene; histone-lysine N- 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved methyltransferase SETMAR; metnase; hsMar1; SET domain and mariner transposase fusion gene-containing protein; METNASE; Entrez Gene ID 6419 Protein Refseq NP_001230652 UniProt ID Q53H47 Chromosome Location 3p26.2 Pathway Lysine degradation; Function endonuclease activity; histone-lysine N-methyltransferase activity; hydrolase activity; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.