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A Systemic Review of Vegetable Poisoning and Challenges in Management

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A Systemic Review of Vegetable Poisoning and Challenges in Management Review Article http://doi.org/ 10.18231/j.ijfmts.2019.002 A systemic review of vegetable poisoning and challenges in management Sukhdeep Singh1, Mahesh Kumar2,*, Arvind Kumar3, Rishabh Kumar Singh4 1,3Professor, 2Assistant Professor, 4Senior Resident, Dept. of Forensic medicine and Toxicology, 1,3,4Lady Hardinge Medical College, Connaught Place, Delhi, 3Indira Gandhi Medical College, Shimla, Himachal Pradesh, India *Corresponding Author: Mahesh Kumar Email: [email protected] Abstract Plants have been friends and foes to the humanity. The plant products as a remedy to many ailments have been used since the advent of human civilisation. On the darker side many plants on the planet are hazardous to human health. The accidental or intentional consumption can be deleterious to the physical as well as mental well being of the individual. The aim of this review was to highlight common plant poisons along with signs, symptoms, differential diagnosis and management Search of the literature was done from PubMed, EMBASE, MEDLINE, EBook, done to elaborate upon this vast topic. The Role of Poison Information centres is vital in establishing epidemiology and management of poisoning. Identifying new plant poisons and developing their treatment protocols along with spreading awareness is of great significance to the society. Keywords: Plant poisons, Vegetable poison, Alkaloids, Toxin, Antidote, Poison information centre. Introduction a wide diversity of chemical toxins that include alkaloids, The knowledge of poisons is existing since ancient time glycosides, proteins and amino acids however there are and supposed to be as old as human civilization. It may be toxic plants for which a specific chemical responsible for defined as any substance which when ingested, inhaled or toxicity has not been yet determined. absorbed or when applied to, injected into, developed within Fortunately, adverse effects often do not occur or are the body by its chemical action, may cause damage to generally mild following most toxic plant ingestions and no structure or disturbance of function”. Poisons are of therapeutic intervention is necessary. However, some plants vegetable, animal, or mineral depending upon source of are extremely toxic and ingestion of small amounts can origin. cause rapid death. The diagnosis of plant intoxication can be challenging. Analytical tests are available to detect some Aims and Objectives plant toxins but diagnostic utility is often limited by test The objective was to conduct systemic review of availability and timeliness of results. With a few notable literature to characterize manifestation of different plant exceptions, antidotes are available only for some plant poisons, diagnosis and management along with the role of toxins. General supportive and symptomatic care often is regional poison information centers in cases of poisonings sufficient to successfully treat a symptomatic patient.5 Though this topic is utterly vast and vivid, here some Materials and Methods very important and frequently encountered poisons are PubMed, EMBASE, MEDLINE, EBook, search of the discussed in terms of their mechanism of action, signs and literature were done to evaluate the vegetable poisoning & symptoms, diagnostic and therapeutic challenges in challenges in management. managing their toxicities. Review of Literature Abrus precatorius The history of poison originated before 4500 BC.1 The plant seeds of abrus are used as beads and in Early poisons were exclusively extracted from plant and percussion instruments, are highly toxic because of the animal toxins and some minerals. Plants are beneficial as presence of abrin. It prevents protein synthesis by foodstuffs and many have medicinal properties. However, inactivating the 26S subunit of the ribosome. Symptoms of some plants also have the potential to produce toxicity.2 poisoning include nausea, vomiting, convulsions, liver Socrates (470–390 BC) was sentenced to death by failure, and death, usually after several days of ingestion. hemlock. Pedanius Dioscorides was a Greek army The differential diagnosis of abrin poisoning include sister physician, classified poisons according to their origin poison Ricin, and viperine bite along others. (animal, vegetable, or mineral) and his book De Materia L-abrin biomarker is useful in suspicious abrin 6 Medica is one of the most influential herbal books and is a poisoning. Supportive and symptomatic management of precursor to all modern pharmacopeias.3 Indian abrin poisoning is mainstay of treatment including adequate surgeon Sushruta defined the stages of slow poisoning, hydration and correction of electrolyte abnormalities. Life- antidotes and traditional substance for treatment of threatening complications such as liver failure, renal failure, poisoning.4 and cerebral edema warrant the testing of renal and liver 7 A large number of plants can cause adverse effects function. when ingested by animals or people. Plant toxicity is due to IP International Journal of Forensic Medicine and Toxicological Sciences, January-March, 2019;4(1) 4-9 4 Sukhdeep Singh et al. A systemic review of vegetable poisoning and challenges in management Ricin is a toxic, naturally occurring lectin produced in poison when administered internally, calotropis acts as a the seeds of the castor oil plant, Ricinus communis. Ricin's gastro-intestinal irritant and cerebrospinal poison. When widespread availability makes it a viable biological weapon. dropped in the eye it produces severe irritation and chemosis Ricin is very toxic if inhaled, injected, or ingested. It acts as of conjunctiva and anesthesia, and the inflammatory a toxin by inhibiting protein synthesis.8 Ingestion of ricin reaction may involve the eyesight.16 Management is causes pain, inflammation, and hemorrhage in the mucous supportive. membranes of the gastrointestinal system lead to nausea, vomiting, diarrhea, difficulty in swallowing, melena and Croton tiglium (Jamālgoṭa) hematemesis. Hypovolemia caused by gastrointestinal fluid It is an important medicinal plant, which is used for the loss can lead to organ failure in the pancreas, kidney, liver, treatment of constipation, dyspepsia, dysenteries, and GI tract and progress to shock. Symptoms of ricin gastrointestinal disorders, intestinal inflammation, inhalation are different from those caused by ingestion. It rheumatism, peptic ulcer, visceral pain, and headache.17,18 include a cough, fever, asthma dry, sore throat, congestion The toxicity of C. tiglium seeds is due to the presence of while skin exposure of ricin can cause an allergy. This is phorbol esters and crotonic acid along with other indicated by edema of the eyes and lips, erythema, skin constituents. Poisoning by ingestion leads to injury of, the blisters. It can be differentially diagnosed from abrin digestive tract manifesting as abdominal cramps burning poisoning, toxin inhalation (such as staphylococcal sensation in the whole abdomen along with bloody diarrhea, enterotoxin B or trichothecene mycotoxins), and chemical congestion, serious edema of GI tract. Mainstay of treatment warfare agents such as phosgene. Aerosolized ricin is is supportive. Antispasmodic and Oral Rehydration distinguished from routine infections by progressive Therapy (ORT) is of great help respiratory symptoms in spite of antibiotics.9 Symptomatic and supportive treatments include intravenous Argemone Mexicana fluids or electrolytes, airway management, assisted Epidemic dropsy is a clinical state resulting from use of ventilation, or giving medications to remedy seizures and edible oils adulterated with Argemone Mexicana oil. low blood pressure are mainstay of treating ricin poisoning. Sanguinarine and dehydrosanguinarine are two major toxic Possible treatments if the ricin has been ingested recently is alkaloids of Argemone oil, which cause widespread ingesting activated charcoal or by performing gastric capillary dilatation, proliferation and increased capillary lavage.10 permeability. Leakage of the protein-rich plasma component into the extracellular compartment leads to the formation of Marking nut (Semecarpus anacardium, oriental cashew oedema. The haemodynamic consequences of this vascular nut) dilatation and permeability lead to a state of relative It is a product of deciduous tree found in the outer hypovolemia with a constant stimulus for fluid and salt Himalayas is believed to contain therapeutic properties and conservation by the kidneys. Illness begins with has been used extensively in Ayurvedic medicine since gastroenteric symptoms followed by cutaneous erythema ancient times. This blackish nut leaves an indelible ink and and pigmentation. Respiratory symptoms such as cough, is recognized to have caused washerman's dermatitis among shortness of breath and orthopnoea progressing to frank British soldiers in the 1940s.11 Several case reports of right-sided congestive cardiac failure are seen. Mild to contact dermatitis caused by the marking nut have been moderate anaemia, hypoproteinaemia, mild to moderate described from sub continental India, related to its use as renal azotemia, retinal haemorrhages, and glaucoma are hair dye, voodoo treatment, remedy for eczema or tattoo common manifestations. The largest epidemic of the disease removal. The contact allergen is thought to be urushiol.12,13 in India affected Delhi and its neighboring states during the Anaphylaxis to the marking nut subsequent to oral ingestion months of August-September 1998. Over 3000 persons fell is mediated by specific IgE to one or more
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