Department of Medicine Annual Report
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Emergency Behavioral Health Services
ALERT #24 ___________________ October 5, 2007 EMERGENCY BEHAVIORAL HEALTH SERVICES POLICIES AND PROCEDURES FOR EMERGENCY SERVICES PROGRAMS AND HOSPITAL EMERGENCY DEPARTMENTS FOR MBHP MEMBERS AND UNINSURED CONSUMERS The following information should be communicated immediately to other appropriate staff in your organization. The Massachusetts Behavioral Health Partnership (MBHP) is the company that manages behavioral health (mental health and substance abuse) services for MassHealth’s Primary Care Clinician (PCC) Plan Members*. Additionally, MBHP is contracted with the Department of Mental Health to manage most of the Emergency Services Programs (ESPs) across the Commonwealth. In that role, MBHP is issuing this Alert to hospital Emergency Departments (EDs), MBHP network providers, and other interested stakeholders in order to provide clarification and guidance relative to the management of behavioral health emergencies in the ED setting. More specifically, this Alert delineates the roles and responsibilities of the Emergency Services Programs (ESPs) and describes an individual’s progression through this system, with a goal of expediting his or her movement through the hospital ED and into acute behavioral health services, as medically necessary. ESPs function as a “safety net” for all citizens of the Commonwealth regardless of age, payer, or ability to pay. It is important to note that the policies and procedures in this Alert applies to those populations for whom the ESPs are contracted with MBHP to serve, which includes MBHP members, MassHealth (non-MCO enrolled) Members, uninsured consumers, and DMH consumers. However, it is also important to note that MassHealth also requires the four Managed Care Organizations (MCOs) contracted with MassHealth to utilize the ESP system for emergency behavioral health services for MassHealth MCO enrolled Members. -
Community Choice Acute Care Hospital Listing Effective July 1, 2017 When You Use a Community Choice Hospital, You Pay a $275 Inpatient Copay Per Calendar Quarter
UNICARE STATE INDEMNITY PLAN Community Choice Acute Care Hospital Listing Effective July 1, 2017 When you use a Community Choice hospital, you pay a $275 inpatient copay per calendar quarter. Community Choice members can also use additional hospitals for the same $275 copay for certain complex procedures and neonatal ICUs. To look for hospitals, go to unicarestateplan.com and, under the Quick Links tab on the Members page, select Look for health care providers. When you use non-Community Choice hospitals, your out-of-pocket costs are higher. Addison Gilbert Hospital Lawrence Memorial Hospital Anna Jaques Hospital Leominster Hospital (UMass Memorial) Athol Memorial Hospital Leonard Morse Hospital Baystate Franklin Medical Center Lowell General Hospital Baystate Medical Center Mary Lane Hospital (Baystate) Berkshire Medical Center Massachusetts Eye and Ear Beth Israel Deaconess Medical Center – Boston Melrose-Wakefield Hospital Beverly Hospital Mercy Medical Center Brockton Hospital Merrimack Valley Hospital Burbank Hospital (UMass Memorial) Milford Regional Medical Center Cambridge Hospital Milton Hospital (Beth Israel Deaconess) Cape Cod Hospital Morton Hospital Carney Hospital Mount Auburn Hospital Charlton Memorial Hospital Nashoba Valley Medical Center Children’s Hospital Boston Needham Hospital (Beth Israel Deaconess) Cooley Dickinson Hospital New England Baptist Hospital *Dana-Farber Cancer Institute (Boston location only) Noble Hospital (Baystate) Emerson Hospital Norwood Hospital Everett Hospital (formerly Whidden Hospital) Plymouth -
Recent Advances in Drug Discovery of GPCR Allosteric Modulators
Recent Advances in Drug Discovery of GPCR Allosteric Modulators ADDEX Pharma S.A., Head of Core Chemistry Chemin Des Aulx 12, 1228 Plan-les-Ouates, Geneva, Switzerland Jean-Philippe Rocher, PhD results in a number of differentiating factors. In fact, most Introduction allosteric modulators have little or no effect on receptor function until the active site is bound by an orthosteric The importance of the allosteric regulation of cellular ligand. Allosteric modulators therefore have multiple functions has been known for decades and even the word potential advantages compared to small molecule and “allosterome,” which describes the endogenous alloste- biologic orthosteric drugs. In particular, they offer new ric regulator molecules of a cell, has been proposed 1. chemistry possibilities allowing access to well known tar- Although best described as modulators of enzymes, gets that have been considered intractable to historical advances in molecular biology and robotic HTS technolo- small molecule approaches. For example, allosteric mod- gies recently allowed the discovery of small molecule allo- ulators may soon be developed for targets which hereto- steric modulators of various biological systems, including fore have been only successfully targeted with proteins GPCR and non-GPCR targets. Today, allosteric modula- and peptides. In other words, allosteric drugs with all the tors appear to be an emerging class of orally available advantages of small molecules - brain penetration, eas- therapeutic agents that can offer a competitive advantage ier manufacturing, distribution and oral administration over classical “orthosteric” drugs. This potential stems - may soon be viewed as the best life cycle management from their ability to offer greater selectivity and differ- strategy for protein therapeutics 2. -
Color Our Collections 2019
COLOR OUR COLLECTIONS 2019 @HarvardHistMed #ColorOurCollections Enabling the history of medicine to inform contemporary medicine and society The Center for the History of Medicine enables the history of medicine to inform contemporary medicine and deepens our understanding of the society in which medicine is embedded. One of the world's leading resources for the study of the history of health and medicine, the Center attracts a global audience of researchers to its integrated collections of rare books, journals, archives, manuscripts, artifact collections, and visual, sound, and moving image works. Our public programs, exhibits, initiatives, and content curation activities are directed to a diverse audience of health professionals, students, academic researchers, and the general public and derive strength of purpose from the Harvard Medical School, Harvard School of Dental Medicine, Harvard T. H. Chan School of Public Health, Boston Medical Library, and Longwood Medical and Academic Area communities. Visit our online digital collections site, OnView (collections.countway.harvard.edu/onview/), to browse digital exhibits, documents, photographs, museum objects, and more. Visit our blog (cms.www.countway.harvard.edu/wp/) to learn about collections, events, and initiatives; and follow us on Twitter and Instagram: @HarvardHistMed. The Center for the History of Medicine is part of the Francis A. Countway Library of Medicine, a partnership of the Harvard Medical School and Boston Medical Library. Learn more at c ountway.harvard.edu. The Center for the History of Medicine, Francis A. Countway Library of Medicine, a partnership of the Harvard Medical School and Boston Medical Library #ColorOurCollections @HarvardHistMed Theatrum Chemicum Britannicum, 1652. Available via the Medical Heritage Library: https://archive.org/details/theatrumchemicum00ashm/page/n6 The Center for the History of Medicine, Francis A. -
Harvard Library Bulletin, Volume 6.2)
Harvard Library bibliography: Supplement (Harvard Library Bulletin, Volume 6.2) The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Carpenter, Kenneth E. 1996. Harvard Library bibliography: Supplement (Harvard Library Bulletin, Volume 6.2). Harvard Library Bulletin 6 (2), Summer 1995: 57-64. Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:42665395 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA 57 Harvard Library Bibliography: Supplement his is a list of selected new books and articles of which any unit of the Harvard T University Library is the author, primary editor, publisher, or subject. The list also includes scholarly and professional publications by Library staff. The bibli- ography for 1960-1966 appeared in the Harvard Library Bulletin, 15 (1967), and supplements have appeared in the years following, most recently in Vol. 3 (New Series), No. 4 (Winter 1992-1993). The list below covers publications through mid-1995. Alligood, Elaine. "The Francis A. Countway Library of Medicine: Poised for the Future, Guided by the Past," in Network News, the quarterly publication of the Massachu- setts Health Sciences Library Network (August 1994). (Elaine Alligood was formerly Assistant Director for Marketing in the Countway Library of Medicine.) Altenberger, Alicja and John W. Collins III. "Methods oflnstruction in Management for Libraries and Information Centers" in New Trends in Education and Research in Librarianshipand InformationScience (Poland:Jagiellonian University, 1993), ed. -
Wayfair Preferred (Narrow) Network Plan Hospitals
Wayfair Preferred (Narrow) Network Hospitals Hospital Name City State Addison Gilbert Hospital Gloucester MA Anna Jaques Hospital Newburyport MA BayRidge Hospital (acute psychiatric hospital) Lynn MA Beth Israel Deaconess Medical Center—Boston Boston MA Beth Israel Deaconess Hospital—Milton Milton MA Beth Israel Deaconess Hospital—Needham Campus Needham MA Beth Israel Deaconess Hospital—Plymouth Plymouth MA Beverly Hospital Beverly MA Boston Children’s Hospital Boston MA Boston Medical Center Boston MA Brigham and Women’s/Mass General Health Care Center at Patriot Place Foxborough MA Cambridge Health Alliance—Cambridge Campus Cambridge MA Cambridge Health Alliance—Somerville Campus Somerville MA Cambridge Health Alliance—Whidden Campus Everett MA Carney Hospital Dorchester MA Clinton Hospital Clinton MA Cooley Dickinson Hospital Northampton MA Emerson Hospital Concord MA Faulkner Hospital Jamaica Plain MA Good Samaritan Medical Center Brockton MA HealthAlliance Hospitals—Burbank Campus Fitchburg MA HealthAlliance Hospitals—Leominster Campus Leominster MA Heywood Hospital Gardner MA Holyoke Medical Center Holyoke MA Lahey Hospital and Medical Center Burlington MA Hospital Name City State Lahey Medical Center Peabody MA Lawrence General Hospital Lawrence MA Lawrence Memorial Hospital Medford MA Lowell General Hospital (includes the campus Lowell MA formerly known as Saints Medical Center) Massachusetts Eye and Ear®´ Infirmary Boston MA Mass General/North Shore Center for Outpatient Care Danvers MA Melrose-Wakefield Hospital Melrose MA Mercy -
Biased Signaling of G Protein Coupled Receptors (Gpcrs): Molecular Determinants of GPCR/Transducer Selectivity and Therapeutic Potential
Pharmacology & Therapeutics 200 (2019) 148–178 Contents lists available at ScienceDirect Pharmacology & Therapeutics journal homepage: www.elsevier.com/locate/pharmthera Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential Mohammad Seyedabadi a,b, Mohammad Hossein Ghahremani c, Paul R. Albert d,⁎ a Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Iran b Education Development Center, Bushehr University of Medical Sciences, Iran c Department of Toxicology–Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Iran d Ottawa Hospital Research Institute, Neuroscience, University of Ottawa, Canada article info abstract Available online 8 May 2019 G protein coupled receptors (GPCRs) convey signals across membranes via interaction with G proteins. Origi- nally, an individual GPCR was thought to signal through one G protein family, comprising cognate G proteins Keywords: that mediate canonical receptor signaling. However, several deviations from canonical signaling pathways for GPCR GPCRs have been described. It is now clear that GPCRs can engage with multiple G proteins and the line between Gprotein cognate and non-cognate signaling is increasingly blurred. Furthermore, GPCRs couple to non-G protein trans- β-arrestin ducers, including β-arrestins or other scaffold proteins, to initiate additional signaling cascades. Selectivity Biased Signaling Receptor/transducer selectivity is dictated by agonist-induced receptor conformations as well as by collateral fac- Therapeutic Potential tors. In particular, ligands stabilize distinct receptor conformations to preferentially activate certain pathways, designated ‘biased signaling’. In this regard, receptor sequence alignment and mutagenesis have helped to iden- tify key receptor domains for receptor/transducer specificity. -
Cell Penetrating Peptides, Novel Vectors for Gene Therapy
pharmaceutics Review Cell Penetrating Peptides, Novel Vectors for Gene Therapy Rebecca E. Taylor 1 and Maliha Zahid 2,* 1 Mechanical Engineering, Biomedical Engineering and Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; [email protected] 2 Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA * Correspondence: [email protected]; Tel.: +1-412-692-8893; Fax: +1-412-692-6184 Received: 5 February 2020; Accepted: 1 March 2020; Published: 3 March 2020 Abstract: Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular membranes in an intact, functional form. Since their initial description and characterization, the field of cell penetrating peptides as vectors has exploded. The cargoes they can deliver range from other small peptides, full-length proteins, nucleic acids including RNA and DNA, liposomes, nanoparticles, and viral particles as well as radioisotopes and other fluorescent probes for imaging purposes. In this review, we will focus briefly on their history, classification system, and mechanism of transduction followed by a summary of the existing literature on use of CPPs as gene delivery vectors either in the form of modified viruses, plasmid DNA, small interfering RNA, oligonucleotides, full-length genes, DNA origami or peptide nucleic acids. Keywords: cell penetrating peptides; protein transduction domains; gene therapy; small interfering RNA 1. Introduction The plasma membrane of a cell is essential to its identity and survival, but at the same time presents a barrier to intracellular delivery of potentially diagnostic or therapeutic cargoes. -
Equity Research
Equity Research Telco Friday,07 February 2020 Telco OVERWEIGHT Maintain Telco price tracker Jan 2020 TLKM relative to JCI Index Telkomsel’s (TSEL) recent products suggest potential change in market dynamics. In response, XL remains defensive, while we are seeing some xxxx positive indications further at the lower end, and thus maintain our overweight sector call. We introduce our telco scorecard to track price effects and network changes, with TLKM and EXCL having the most network leverage. A different ballgame with By.U. Growth in traffic vols continue to be sizeable as TSEL and XL Axiata reported traffic growth of ~+39%/38%yoy respectively, and Indosat at about +61%yoy during the festive period in Dec-Jan according to news reports. TSEL’s core data offerings have not been altered since 4Q19 as TSEL would want to evaluate the traction effects from “OMG!” and the new product line “By.U”. While OMG! does enrich TSEL’s portfolio with SoSMed and content, By.U by contrast seeks to get more traffic with effective GB yields to levels below Rp4,300. By.U is designed to be set apart from TSEL’s branding to pursue millennials and student groups. While there is time to tweak prices further before the next Lebaran season in 2020, By.U is potentially disruptive EXCL relative to JCI Index putting pressure on contenders’ value chains. xxxx XL rewards existing users with discounts. Our channel check reveals that XL itself offered discounts in the 8-13% range on flagship products for existing users, while a new XL prepaid user can choose a service only based on nominal prices. -
1 Advances in Therapeutic Peptides Targeting G Protein-Coupled
Advances in therapeutic peptides targeting G protein-coupled receptors Anthony P. Davenport1Ϯ Conor C.G. Scully2Ϯ, Chris de Graaf2, Alastair J. H. Brown2 and Janet J. Maguire1 1Experimental Medicine and Immunotherapeutics, Addenbrooke’s Hospital, University of Cambridge, CB2 0QQ, UK 2Sosei Heptares, Granta Park, Cambridge, CB21 6DG, UK. Ϯ Contributed equally Correspondence to Anthony P. Davenport email: [email protected] Abstract Dysregulation of peptide-activated pathways causes a range of diseases, fostering the discovery and clinical development of peptide drugs. Many endogenous peptides activate G protein-coupled receptors (GPCRs) — nearly fifty GPCR peptide drugs have been approved to date, most of them for metabolic disease or oncology, and more than 10 potentially first- in-class peptide therapeutics are in the pipeline. The majority of existing peptide therapeutics are agonists, which reflects the currently dominant strategy of modifying the endogenous peptide sequence of ligands for peptide-binding GPCRs. Increasingly, novel strategies are being employed to develop both agonists and antagonists, and both to introduce chemical novelty and improve drug-like properties. Pharmacodynamic improvements are evolving to bias ligands to activate specific downstream signalling pathways in order to optimise efficacy and reduce side effects. In pharmacokinetics, modifications that increase plasma-half life have been revolutionary. Here, we discuss the current status of peptide drugs targeting GPCRs, with a focus on evolving strategies to improve pharmacokinetic and pharmacodynamic properties. Introduction G protein-coupled receptors (GPCRs) mediate a wide range of signalling processes and are targeted by one third of drugs in clinical use1. Although most GPCR-targeting therapeutics are small molecules2, the endogenous ligands for many GPCRs are peptides (comprising 50 or fewer amino acids), which suggests that this class of molecule could be therapeutically useful. -
Boston a Guide Book to the City and Vicinity
1928 Tufts College Library GIFT OF ALUMNI BOSTON A GUIDE BOOK TO THE CITY AND VICINITY BY EDWIN M. BACON REVISED BY LeROY PHILLIPS GINN AND COMPANY BOSTON • NEW YORK • CHICAGO • LONDON ATLANTA • DALLAS • COLUMBUS • SAN FRANCISCO COPYRIGHT, 1928, BY GINN AND COMPANY ALL RIGHTS RESERVED PRINTED IN THE UNITED STATES OF AMERICA 328.1 (Cfte gtftengum ^regg GINN AND COMPANY • PRO- PRIETORS . BOSTON • U.S.A. CONTENTS PAGE PAGE Introductory vii Brookline, Newton, and The Way about Town ... vii Wellesley 122 Watertown and Waltham . "123 1. Modern Boston i Milton, the Blue Hills, Historical Sketch i Quincy, and Dedham . 124 Boston Proper 2 Winthrop and Revere . 127 1. The Central District . 4 Chelsea and Everett ... 127 2. The North End .... 57 Somerville, Medford, and 3. The Charlestown District 68 Winchester 128 4. The West End 71 5. The Back Bay District . 78 III. Public Parks 130 6. The Park Square District Metropolitan System . 130 and the South End . loi Boston City System ... 132 7. The Outlying Districts . 103 IV. Day Trips from Boston . 134 East Boston 103 Lexington and Concord . 134 South Boston .... 103 Boston Harbor and Massa- Roxbury District ... 105 chusetts Bay 139 West Roxbury District 105 The North Shore 141 Dorchester District . 107 The South Shore 143 Brighton District. 107 Park District . Hyde 107 Motor Sight-Seeing Trips . 146 n. The Metropolitan Region 108 Important Points of Interest 147 Cambridge and Harvard . 108 Index 153 MAPS PAGE PAGE Back Bay District, Showing Copley Square and Vicinity . 86 Connections with Down-Town Cambridge in the Vicinity of Boston vii Harvard University ... -
Manager and Executive Compensation in Hospitals and Health Systems Survey Report
2019 Manager and Executive Compensation in Hospitals and Health Systems Survey Report Survey data effective January 1, 2019 © 2019 SullivanCotter, Inc. All rights reserved. 200 W. Madison Street, Suite 2450 Chicago, IL 60606-3416 2019 MANAGER AND EXECUTIVE COMPENSATION IN HOSPITALS AND HEALTH SYSTEMS SURVEY REPORT Survey data effective January 1, 2019 LICENSE AGREEMENT LICENSE AGREEMENT By accessing or downloading the Survey Report files online or by opening the packaging for this Survey Report, you agree to the terms of this License Agreement (this “Agreement”). If you do not agree to these terms and have not yet accessed or downloaded the Survey Report files or opened the packaging for this Survey Report, you may cancel your online purchase or download at this time or you may return this Survey Report to SullivanCotter, Inc. for a full refund within thirty (30) days of receipt, but you may not access or download the Survey Report files or open the packaging for, or otherwise use, this Survey Report. Accessing or downloading the Survey Report files or opening the packaging, or otherwise using, this Survey Report binds you to this Agreement. This Agreement is entered into by and between SullivanCotter, Inc. ("SullivanCotter") and the purchaser or participant of this Survey Report (the “Licensee”). In consideration of the mutual covenants in this Agreement, SullivanCotter and the Licensee agree as follows: Grant of License. This Survey Report contains the aggregation of compensation data and other data provided to SullivanCotter by its survey participants, statistics, tables, reports, research, aggregations, calculations, data analysis, formulas, summaries, content, text and other information and materials provided to the Licensee by SullivanCotter through any other means, whether digital or hard copy, related thereto (the “Aggregated Data”).