Dietary Agents in Cancer Chemoprevention and Treatment
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Journal of Oncology Dietary Agents in Cancer Chemoprevention and Treatment Guest Editors: Julian J. Raffoul, Omer Kucuk, Fazlul H. Sarkar, and Gilda G. Hillman Dietary Agents in Cancer Chemoprevention and Treatment Journal of Oncology Dietary Agents in Cancer Chemoprevention and Treatment Guest Editors: Julian J. Raffoul, Omer Kucuk, Fazlul H. Sarkar, and Gilda G. Hillman Copyright © 2012 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Journal of Oncology.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is prop- erly cited. Editorial Board Thomas E. Adrian, UAE Toshiyuki Ishiwata, Japan Alfredo Quinones-Hinojosa, USA Massimo Aglietta, Italy Andreas H. Jacobs, Germany JanetS.Rader,USA Bruce Baguley, New Zealand Ismail Jatoi, USA Dirk Rades, Germany A. J. M. Balm, The Netherlands Ozkan Kanat, Turkey Zvi Ram, Israel F. Barr, USA Gertjan Kaspers, The Netherlands Dirk Reinhardt, Germany Søren M. Bentzen, USA Michael J. Kerin, Ireland Paul G. Richardson, USA Rolf Bjerkvig, Norway Turker¨ Kilic¸, Turkey Michel Rigaud, France P. Black, USA Timothy J. Kinsella, USA Jorg¨ Ritter, Germany Susana M. Campos, USA Jorg Kleeff,Germany M. Roach, USA Michael Carducci, USA George O. Klein, Sweden BerndF.M.Romeike,Germany Stefano Cascinu, Italy Mark J. Krasna, USA Volker Rudat, Saudi Arabia Soonmee Cha, USA M. Kudo, Japan Thomas Rutherford, USA Susan Chang, USA Robert Langley, USA Siham Sabri, Canada Thomas R. Chauncey, USA A. Lipton, USA Aysegula A. Sahin, USA Srikumar P. Chellappan, USA J. S. Loeffler, USA Giovanni Scambia, Italy Dennis S. Chi, USA Dario Marchetti, USA Paul M. Schneider, Switzerland Edward A. Copelan, USA S. Masood, USA Peter E. Schwartz, USA Richard Crevenna, Austria Keisuke Masuyama, Japan Jalid Sehouli, Germany Massimo Cristofanilli, USA Ian E. McCutcheon, USA Edgar Selzer, Austria Christos G. Dervenis, Greece Raju Mehta, USA Francis Seow-Choen, Singapore Andreas Dietz, Germany Minesh P. Mehta, USA Dong Moon Shin, USA Frederick E. Domann, USA Sofia D. Merajver, USA Keshav K. Singh, USA Avraham Eisbruch, USA Bradley J. Monk, USA Judith A. Smith, USA Joann G. Elmore, USA Yoshihiro Moriya, Japan Lawrence J. Solin, USA Thomas J. Fahey, UK Satoru Motoyama, Japan Luis Souhami, Canada Dominic Fan, USA JamesL.Mulshine,USA Alphonse G. Taghian, USA Phillip G. Febbo, USA Arya Nabavi, Germany Hiromitsu Takeyama, Japan Douglas L. Fraker, USA P. Neven, Belgium Nelson N. H. Teng, USA H. S. Friedman, USA Christophe Nicot, USA Chris Terhaard, The Netherlands Hani Gabra, UK Felix Niggli, Switzerland D. S. Tyler, USA Cicek Gercel-Taylor, USA Patrizia Olmi, Italy Raul A. Urrutia, USA William J. Gradishar, USA Jan I. Olofsson, Norway V. Valentini, Italy Akira Hara, Japan Fred´ erique´ Penault-Llorca, France Daniel Vallbohmer,¨ Germany Robert M. Hermann, Germany Richard T. Penson, USA Michiel van den Brekel, The Netherlands Mario A. Hermsen, Spain MichaelC.Perry,USA J. R. Van Nagell, USA Fred H. Hochberg, USA Joseph M. Piepmeier, USA Bruno Vincenzi, Italy William J. Hoskins, USA M. Steven Piver, USA J. A. Werner, Germany Contents Dietary Agents in Cancer Chemoprevention and Treatment,JulianJ.Raffoul, Omer Kucuk, Fazlul H. Sarkar, and Gilda G. Hillman Volume 2012, Article ID 749310, 2 pages Selenium in the Prevention of Anthracycline-Induced Cardiac Toxicity in Children with Cancer, Nurdan Tacyildiz, Derya Ozyoruk, Guzin Ozelci Kavas, Gulsan Yavuz, Emel Unal, Handan Dincaslan, Semra Atalay, Tayfun Ucar, Aydan Ikinciogullari, Beyza Doganay, Gulsah Oktay, Ayhan Cavdar, and Omer Kucuk Volume 2012, Article ID 651630, 6 pages Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency, Rita Rosati, Hongzhi Ma, and Diane C. Cabelof Volume 2012, Article ID 105949, 17 pages Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFκB and Akt/mTOR Signaling Pathways, K. Sahin, M. Tuzcu, N. Basak, B. Caglayan, U. Kilic, F. Sahin, and O. Kucuk Volume 2012, Article ID 461562, 6 pages DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents,JulianJ.Raffoul, Ahmad R. Heydari, and Gilda G. Hillman Volume 2012, Article ID 370481, 11 pages Potential Anticancer Properties of Grape Antioxidants, Kequan Zhou and Julian J. Raffoul Volume 2012, Article ID 803294, 8 pages Potential Role of Garcinol as an Anticancer Agent, Nadia Saadat and Smiti V. Gupta Volume 2012, Article ID 647206, 8 pages Lycopene, Tomato Products, and Prostate Cancer Incidence: A Review and Reassessment in the PSA Screening Era, Melissa Y. Wei and Edward L. Giovannucci Volume 2012, Article ID 271063, 7 pages Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest, Suwit Duangmano, Phorntip Sae-lim, Apichart Suksamrarn, Pimpicha Patmasiriwat, and Frederick E. Domann Volume 2012, Article ID 601682, 8 pages Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells, Mansi A. Parasramka and Smiti Vaid Gupta Volume 2012, Article ID 709739, 8 pages The Role of Nutraceuticals in Chemoprevention and Chemotherapy and Their Clinical Outcomes, Sabita N. Saldanha and Trygve O. Tollefsbol Volume 2012, Article ID 192464, 23 pages Hindawi Publishing Corporation Journal of Oncology Volume 2012, Article ID 749310, 2 pages doi:10.1155/2012/749310 Editorial Dietary Agents in Cancer Chemoprevention and Treatment Julian J. Raffoul,1 Omer Kucuk,2 Fazlul H. Sarkar,3 and Gilda G. Hillman4 1 Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA 2 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA 3 Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA 4 Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA Correspondence should be addressed to Julian J. Raffoul, julian.raff[email protected] Received 6 December 2012; Accepted 6 December 2012 Copyright © 2012 Julian J. Raffoul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer chemoprevention using natural or synthetic com- on this association. K. Zhou and J. J. Raffoul discuss the pounds to prevent or suppress the development of can- composition and cancer-protective effects of major phenolic cer, is an area of active investigation. Many compounds antioxidants in grape skin and grape seed extracts. M. belonging to diverse chemical classes have been identified A. Parasramka and S. V. Gupta provide original research as potential chemopreventive agents, including vitamins and demonstrating the anticancer properties of garcinol alone, minerals, naturally occurring phytochemicals, and synthetic or combined with curcumin, on pancreatic cancer cells. compounds. Understanding the molecular mechanisms of Garcinol, a polyisoprentylated benzophenone extracted from cancer chemoprevention is not only important for the safe the rind of the fruit Garcinia indica, a plant found in tropical application of these compounds in populations of patients at regions, has antioxidant and anti-inflammatory properties high risk for cancer, but also allows for further development and its role as anticancer agent is thoroughly discussed in the of novel treatment regimens for cancer patients. review from N. Saadat and S. V. Gupta. This special issue contains original research as well as Two manuscripts discussing the effect of dietary agents review articles that are intended to stimulate the continuing on DNA repair capacity are also part of this special issue. efforts to understand the use of dietary agents in cancer InamanuscriptbyJ.J.Raffoul et al., the potential for chemoprevention and treatment. The lead article by S. N. targeting the DNA base excision repair enzyme APE1/Ref- Saldanha and T. O. Tollefsbol provides a comprehensive 1 using dietary agents such as soy isoflavones, resveratrol, review of dietary agents that have shown strong chemopre- curcumin, ascorbate, and alpha-tocopherol is discussed. The ventive and therapeutic properties in vitro. They also discuss potential for these natural compounds to be combined with the design and modification of these bioactive compounds chemotherapy or radiotherapy for the more effective treat- for pre-clinical and clinical applications. ment of cancer are also reviewed. A proposed mechanism of Dietary intake of foods rich in antioxidant compounds action is discussed and an attempt is made to delineate which has been suggested to be cancer protective. However, ran- of the two activities of APE1/Ref-1 (DNA repair versus redox domized clinical trials and epidemiologic studies on the activation of cellular transcription factors) is responsible for association between intake of foods rich in antioxidants the observed effects. The second manuscript by R. Rosati et and cancer incidence have yielded mixed results. M. Y. Wei al. reviews the role for dietary folate in the prevention of and E. L. Giovannuci discuss the epidemiologic consider- colorectal cancer. Data are presented which demonstrate that ations of lycopene as a chemopreventive agent, including inhibition of DNA repair is protective in the development