DETERMINING the ROLE of SEROTONIN in ANTIDEPRESSANT ACTION, AS REVEALED UTILIZING the SERT MET172 MOUSE MODEL by Alexander Greer
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Journal Deselection List-A 1 A.M.A. Archives of Dermatology 1955-1960 A.M.A. Archives of Dermatology and Syphilology 1951-1955
Journal Deselection List-A 1 A.M.A. archives of dermatology 1955-1960 A.M.A. archives of dermatology and syphilology 1951-1955 A.M.A. archives of general psychiatry 1959-1960 A.M.A. archives of industrial health 1955-1960 A.M.A. archives of industrial hygiene and occupational medicine 1951-1954 A.M.A. archives of internal medicine 1951-1960 A.M.A. archives of neurology 1959-1960 A.M.A. archives of neurology and psychiatry 1950-1959 A.M.A. archives of ophthalmology 1951-1960 A.M.A. archives of otolaryngology 1951-1960 A.M.A. archives of pathology 1951-1960 A.M.A. archives of surgery 1951-1960 A.M.A. journal of diseases of children 1956-1960 AACN advanced critical care 2006 AACN clinical issues 1995-2006 AACN clinical issues in critical care nursing 1990-1994 AANA journal 1974-2006 Abdmonial imaging 1993-1996 Abdmonial surgery 1970-1984 Abstracts of health care management studies 1978-79, 1982-87 Abstracts of hospital management studies 1965-1978 Abstracts of the annual meeting of the American 1972-75, 1978- society for microbiology 1990 Abstracts of the general meeting of the American society for microbiology 1991-1996 Abstracts on hygiene 1968-1980 Accomplishments in oncology 1986-1988 Acta allergologica 1948-1977 Acta allergologica. Supplementum 1971-1977 Acta anaesthesiologica scandinavica. Supplementum 1959-2003 Acta anatomica 1945-1998 Acta anatomica. Supplementum 1944-0980 1954-1973, 1975- Acta biochimica polonica 1999 Acta cardiologica 1946-2002 1946-1961, 1969- Acta cardiologica. Supplement 1991 1950-1960, 1966, Acta dermato-venereologica 1970-97 Journal Deselection List-A 2 1941,48,1951- 59,1966,1970- Acta dermato-venereologica. -
Alfred Day Hershey (1908–1997) [1]
Published on The Embryo Project Encyclopedia (https://embryo.asu.edu) Alfred Day Hershey (1908–1997) [1] By: Hernandez, Victoria Keywords: Hershey, Alfred Day [2] Lambda phage [3] Bacteriophage [4] Hershey-Chase experiments [5] During the twentieth century in the United States, Alfred Day Hershey studied phages, or viruses that infect bacteria, and experimentally verified that genes [6] were made of deoxyribonucleic acid, or DNA. Genes are molecular, heritable instructions for how an organism develops. When Hershey started to study phages, scientists did not know if phages contained genes [6], or whether genes [6] were made of DNA or protein. In 1952, Hershey and his research assistant, Martha Chase, conducted phage experiments that convinced scientists that genes [6] were made of DNA. For his work with phages, Hershey shared the 1969 Nobel Prize in Physiology or Medicine [7] with Max Delbrück and Salvador Luria. Hershey conducted experiments with results that connected DNA to the function of genes [6], thereby changing the way scientists studied molecular biology and the development of organisms. Hershey was born on 4 December 1908 to Alma Wilbur and Robert Hershey in Owosso, Michigan. He attended public schools in both Owosso and Lansing, Michigan, where his father worked as a stockkeeper at an automobile factory. For his higher education, Hershey attended Michigan State College, later called Michigan State University, in East Lansing, Michigan. There, he received his Bachelor’s of Science in chemistry in 1930 and his PhD in bacteriology and chemistry in 1934. Hershey wrote his doctoral dissertation on the separation of chemical constituents, or components like sugars, fats, and proteins, from different strains of the Brucella [8] bacterial group. -
RF Annual Report
The Rockefeller Foundation Annual Report *r * w-*"* B* 49 West 4gth Street, New York 2003 The Rockefeller Foundation 318.3 ! PRINTED IN THE UNITED STATES OF AMERICA 2003 The Rockefeller Foundation CONTENTS LETTER OF TRANSMISSION XV FOREWORD BY THE PRESIDENT I DIVISION OF MEDICINE AND PUBLIC HEALTH 19 DIVISION OF NATURAL SCIENCES AND AGRICULTURE III DIVISION OF SOCIAL SCIENCES 209 DIVISION OF HUMANITIES 263 OTHER APPROPRIATIONS 305 FELLOWSHIPS 321 REPORT OF THE TREASURER 355 INDEX 439 2003 The Rockefeller Foundation 2003 The Rockefeller Foundation ILLUSTRATIONS Page Storing grain for studies in genetics and plant breeding at the University of Lund, Sweden iv Electrical charting of the brain at the Burden Neurological Institute, Bristol, England 67 Electrophoresis laboratory in the Biochemical Institute of the University of Uppsala, Sweden 67 The Institute of Genetics, University of Lund, Sweden 68 The new Biochemistry and Virus Laboratory, University of California 123 Using the spectrometer to investigate protein structure at the Brooklyn Polytechnic Institute, New York 124 Sedimentation studies of protein molecules, Yale University 124 The Enzyme Research Institute, University of Wisconsin 143 Cloud chamber at the tower laboratory of the White Mountain Research Station, California 143 Summit of White Mountain Peak, site of a new high altitude laboratory of the White Mountain Research Station 144 A marine expedition from the Scripps Institution of Oceanog- raphy, California H4 Scripps Institution of Oceanography: main buildings and the -
Ii. Gregor Johann Mendel (1822–1884)
Masarykova univerzita Filozofická fakulta Ústav archeologie a muzeologie Muzeologie Ing. Irena Křížová Prezentace osobnosti a díla G. J. Mendela v Brně od jeho „znovuobjevení“ do začátku nacistické okupace (1900–1939) Bakalářská diplomová práce Vedoucí práce: Mgr. Otakar Kirsch, Ph.D. 2012 - 1 - Prohlašuji, že jsem diplomovou práci na téma Prezentace osobnosti a díla G. J. Mendela v Brně od jeho „znovuobjevení“ do začátku nacistické okupace (1900–1939) vypracovala samostatně s využitím uvedených pramenů a literatury. V Brně dne .......... ......................... podpis autorky práce - 2 - Zde bych chtěla poděkovat Mgr. Otakaru Kirschovi, Ph.D., za odborné konzultace, podnětné rady, ochotu a čas, který věnoval mé práci. Zároveň bych chtěla poděkovat své tchýni, PhDr. Ingeborg Křížové, za pomoc s překlady německých pramenů a celé své rodině za podporu, pochopení a večerní čaje s citrónem. - 3 - Obsah Obsah ..................................................................................................................................................3 Použité zkratky: .......................................................................................................................................4 I. ÚVOD ..................................................................................................................................................5 II. GREGOR JOHANN MENDEL (1822–1884) ......................................................................................8 1. Život .................................................................................................................................. -
Sir Alan L. Hodgkin 252
EDITORIAL ADVISORY COMMITTEE Albert J. Aguayo Bernice Grafstein Theodore Melnechuk Dale Purves Gordon M. Shepherd Larry W. Swanson (Chairperson) The History of Neuroscience in Autobiography VOLUME 1 Edited by Larry R. Squire SOCIETY FOR NEUROSCIENCE 1996 Washington, D.C. Society for Neuroscience 1121 14th Street, NW., Suite 1010 Washington, D.C. 20005 © 1996 by the Society for Neuroscience. All rights reserved. Printed in the United States of America. Library of Congress Catalog Card Number 96-70950 ISBN 0-916110-51-6 Contents Denise Albe-Fessard 2 Julius Axelrod 50 Peter O. Bishop 80 Theodore H. Bullock 110 Irving T. Diamond 158 Robert Galambos 178 Viktor Hamburger 222 Sir Alan L. Hodgkin 252 David H. Hubel 294 Herbert H. Jasper 318 Sir Bernard Katz 348 Seymour S. Kety 382 Benjamin Libet 414 Louis Sokoloff 454 James M. Sprague 498 Curt von Euler 528 John Z. Young 554 Sir Alan L. Hodgkin BORN: Banbury, Oxfordshire, England February 5, 1914 EDUCATION: University of Cambridge: Trinity College (1932), Sc.D. (1963) APPOINTMENTS: Fellow, Trinity College, Cambridge (1936 to date) Foulerton Research Professor, Royal Society (1952) Plummer Professor of Biophysics, University of Cambridge (1970) Master of Trinity College, Cambridge (1978) HONORS AND AWARDS: Fellow, Royal Society of London (1948) Royal Medal, Royal Society (1958) Nobel Prize for Medicine or Physiology (1963) Copley Medal, Royal Society (1965) President, Royal Society (1970-1975) Knight of the British Empire (1972) Order of Merit (1973) Foreign Associate, American Academy of Arts and Sciences (1974) Foreign Associate, National Academy of Sciences USA (1974) Sir Alan Hodgkin, together with Andrew Huxley, established the ionic basis of the resting potential in nerve cells and the ionic basis of nerve conduction. -
Professor Sir Alan Hodgkin OM KBE MA Scd FRS 1914-1998
Professor Sir Alan Hodgkin OM KBE MA ScD FRS 1914-1998 A Ian Hodgkin was distinguished for his Disease is named. His father, a friend of contributions to the understanding of Keith Lucas, originator of the All-or-None nerve conduction, the Law, died in 1918 on a excitation of muscle, mission to investigate and phototransduction conditions among in the retina. With his refugees in Armenia. colleagues Bernard Alan Hodgkin's Katz and Andrew autobiography tells us Huxley, he established that being sent away to the ionic basis of the the Downs School, action potential, Colwall, near Malvern, in r e v o I u t i o n i s i n g 4his ninth year was not a neuroscience and happy experience, and laying the foundations subsequent entry to for subsequent work, Gresham's School, Holt, now burgeoning more in Norfolk, found him in than ever, on ion the bottom class. But he channels. In 1963, at worked his way up to win the age of 49, he won Brya Organs portrait of Sir Alm Hodgkin OM as a Scholarship to Trinity the Nobel Prize for Chancenor of the University of Le tr. College, Cambridge, in Physiology and Photogmph courtesy of the University of Leicester Botany, Zoology, and Medicine with Andrew Chemistry. His future Huxley and John Director of Studies, the Eccles. He was a Fellow of the Royal zoologist Carl Pantin, persuaded him to use Society at the age of 40, and held its the time between school and university to Foulerton Research Chair from 1952 to learn as much mathematics, physics, and 1969. -
The Key to Life at the Atomic Level
THE NOBEL PRIZE IN CHEMISTRY 2009 INFORMATION FOR THE PUBLIC The key to life at the atomic level At the beginning of the twentieth century, the chemical foundations for life were a mystery. Today we know how many of the most important processes function, all the way down to the atomic level. The 2009 Nobel Prize in Chemistry is awarded for the detailed mapping of the ribosome – the cell’s own protein factory. The ribosome translates the passive DNA information into form and function. The general theory of evolution, which was published by Charles Darwin in 1859, is based on the assumption that an organism’s properties are hereditary and that, every now and then, random changes occur. Successful changes, which increase the chances of survival of the organism in question, are thus carried forward to future generations. When the scientifc community had digested Darwin’s thoughts, some new questions arose: what exactly is being transferred over generations, where do the random changes occur, and how can they manifest themselves in a living organism? The 2009 Nobel Prize in Chemistry is the third in a series of prizes that show how Darwin’s theories actually function at the level of the atom. Images, generated by means of various X-ray techniques, show how the simple DNA code can manifest itself not only as hearing, feel- ing and taste, or muscles, bone and skin, but also as thoughts and speech. The trilogy of prizes began with one of the most famous Nobel Prizes of all, that of 1962, when James Watson, Francis Crick and Maurice Wilkins were recognised for their elaboration of an atomic model of the double-stranded DNA molecule. -
Andrew Fielding Huxley (1917–2012)
Andrew Fielding Huxley (1917–2012) Michael C. Mackey and Moisés Santillán, Coordinating Editors n A Mathematician’s Apology, G. H. Hardy in recording electrically from the inside of the squid wrote: “A mathematician, like a painter or a giant axon. However, this work was interrupted poet, is a maker of patterns. The mathemati- by the outbreak of World War II. For the first cian’s patterns, like the painter’s or the poet’s, year of the war, Huxley was a clinical student, but Imust be beautiful; the ideas, like the colours when medical teaching in London was stopped by or the words, must fit together in a harmonious air attacks, he changed to work on operational way.” In our opinion these sentiments also apply research in gunnery, first for the Anti-Aircraft to all other areas of science. The work of Andrew Command and later for the Admiralty. F. Huxley (who passed away on May 30, 2012) is In 1941 Huxley was elected to a research fellow- one of the finest examples not only because of ship at Trinity College, Cambridge, and he took up its importance to applied mathematics, biomath- this position at the beginning of 1946, together ematics, and physiology but also because of the with a teaching appointment in the Department beauty of the underlying conceptual framework. of Physiology. On his return to England after a A. F. Huxley has justifiably become one of the research stay in the laboratory of Kenneth S. Cole, best-known scientists of the twentieth century. Hodgkin teamed up with Huxley to measure the A. -
Epistemological and Ethical Aspects of Time in Scientific Research
Epistemological and Ethical Aspects of Time in Scientific Research Von der Philosophischen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades Doktor der Philosophie Dr. phil. genehmigte Dissertation von Daria Jadreškić Erscheinungsjahr 2020 Referent: Prof. Dr. Torsten Wilholt Institut für Philosophie, Leibniz Universität Hannover Korreferentin: Prof. Dr. Anke Büter Department of Philosophy and History of Ideas, Aarhus University Tag der Promotion: 10.06.2020 Acknowledgments I would like to thank my supervisors Torsten Wilholt and Anke Büter for guiding me through the dissertation process in the most academically rigorous, yet most possibly encouraging manner. Conversations with Torsten Wilholt have especially contributed to my argumentation skills, broadness of interest, attention to style, reader-friendliness, and most of all, confidence that this dissertation is achievable. Anke Büter has been a careful reader and an attentive listener of my talks at many conferences that we have attended together. Her feedback has made my work better in various ways every time she provided it and I have learned a lot from being a regular attendant of her talks as well. I am grateful to my research training group DFG-GRK 2073 Hannover-Bielefeld for letting me be a part of the team. I think we are a great crowd of people, who have always managed to make our common research business into a friendly team-building process that has brought me so much fun and insight. I could not have picked a better place to get this thing done. Our research colloquia, theory workshops, and peer group meetings are events that I have always enjoyed, for the talks as well as for the dinners. -
The Physiological Construction of the Neurone Concept (1891-1952) Jean-Gaël Barbara
The physiological construction of the neurone concept (1891-1952) Jean-Gaël Barbara To cite this version: Jean-Gaël Barbara. The physiological construction of the neurone concept (1891-1952). Comptes Rendus. Biologies, 2006. hal-03110545 HAL Id: hal-03110545 https://hal.archives-ouvertes.fr/hal-03110545 Submitted on 14 Jan 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. The physiological construction of the neurone concept (1891-1952) Jean-Gaël Barbara Version auteur de : J.G. Barbara, 2006, « The physiological construction of the neurone concept (1891-1952) », CR Biol, 329, 437-449. J.G. BARBARA Université Pierre et Marie Curie Neurobiologie des Processus Adaptatifs CNRS UMR 7102 Recherches Epistémologiques et Historiques sur les Sciences Exactes et les Institutions Scientifiques REHSEIS CNRS UMR7596 Case 14, 7 quai Saint Bernard, Paris 75005, France. E-mail address: [email protected] (J.G. Barbara). Résumé Les étapes de la construction physiologique du concept de neurone sont décrites. Les idées initiales sur la fonction de la cellule nerveuse aboutissent aux polémiques sur la théorie du neurone et les prétentions spéculatives de l’histophysiologie. Les programmes de recherche de Sherrington et Adrian émergent d’un contexte britannique spécifique et se confrontent à l’oscillographie américaine et au rythme de Berger. -
The Chemical Basis for Life the 2009 Nobel Prize in Chemistry
The chemical basis for life The 2009 Nobel Prize in Chemistry. Part 2 PETER KARUSO The story of the 2009 Nobel Prize in Chemistry is an epic in time and proportion. The second instalment focuses on the final leg of the race for the ribosome and the contri- butions of Tom Steitz, Venki Ramakrishnan and others. he year 1999 was pivotal in the race for the struc- Venkatraman Ramakrishnan Tture of the ribosome – the cell’s largest ‘machine’. Venkatraman Ramakrishnan was born in At the Ribosome Conference in Helsingor, Denmark, Chidambaram, Tamil Nadu, India, in 1952. He in June 1999, several groups revealed their results for obtained his PhD in physics in 1976 from Ohio the !rst time. Peter Moore, Tom Steitz, Venki University, USA. As a student he was much more Ramakrishnan, Harry Noller and Ada Yonath gave interested in his monthly deliveries of Scienti!c Amer- consecutive talks at the meeting. Yonath described ican than his PhD project. He thought the really her results on the 30S subunit but her low-resolution interesting stuff was in the biomolecular sciences results paled in comparison to those of Moore and rather than physics so planned to switch. Ramakr- Steitz, and Noller. However, everyone was amazed at ishnan ended up in Peter Moore’s lab (Chemistry, the results presented by someone who had not previ- Yale) and worked on small-angle neutron scattering of ously been a player in the ribosome area: a dark horse the ribosome from 1978 to 1982. He continued his (Ramakrishnan) had scooped everyone with a 5.5 Å interest in the ribosome at the Brookhaven National resolution structure of the small (30S) ribosomal Laboratory and then at the University of Utah where subunit. -
Reflections on the Legacy of a Legend Glenn T
Reflections on the Legacy of a Legend Glenn T. Seaborg 1912–1999 David L. Clark and David E. Hobart 56 Los Alamos Science Number 26 2000 Reflections on the Legacy of a Legend n February 25th, 1999, chemist, educator, administrator, humanitarian, and Nobel Prize recipient Glenn T. Seaborg died in his home in Lafayette, Cal- Oifornia, at the age of 86. Many know of the scientific accomplishments of the man who has become a legend, and anyone who has attended his lectures can attest to how informative and entertaining Seaborg was. He had an enticing, whim- sical sense of humor and used this talent to drive home his points and to share his passion for “hard” science and his quest for discovery. Seaborg was the architect of the actinide series of the periodic table of elements and codiscoverer of 10 transuranium elements—one of which bears his name (element 106, seaborgium)—and of numerous radioisotopes. His work and achievements have touched many lives, and his discoveries and legacy will continue to touch many lives for generations to come. Glenn T. Seaborg was born in Ishpeming, Michigan, on April 19th, 1912. His family moved to Los Angeles, California, where Seaborg was first exposed to science in high school. Later, he dedicated his life to this endeavor. Seaborg received his A.B. degree from the University of California (U.C.) at Los Angeles in 1934 and his Ph.D. in chemistry from U.C. at Berkeley in 1937. He served as a faculty member at Berkeley from 1939 until his death and was chancellor of that campus from 1958 to 1961.