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Beyond Darwin: Evolvability and the Generation of Novelty Marc Kirschner
Kirschner M BMC Biology 2013, 11:110 http://www.biomedcentral.com/1741-7007/11/110 INTERVIEW Open Access Beyond Darwin: evolvability and the generation of novelty Marc Kirschner Marc Kirschner graduated in biochemistry from North- western University, moving to Berkeley for his doctoral research and with positions at Berkeley, Oxford Univer- sity and Princeton before he took a professorship at Uni- versity of California San Francisco where with Andrew Murray he did seminal research on the control of the cell cycle in Xenopus egg extracts that led to the discov- ery of how cyclin drives the cell cycle, and with Tim Mitchison on the dynamic instability of microtubules. In 1993 he moved to Harvard where in 2003 he became the founding Chair of the HMS Department of Systems Biology and was named the John Franklin Enders Uni- versity Professor in 2009. The two books he wrote with John Gerhart, Cells, Embryos and Evolution (Blackwell, 1997) and The Plausibility of Life: Resolving Darwin’sDi- lemma (Yale University Press, 2005), reflect his deep and longstanding interest in how biological systems evolve. Here he gives his view of the evolution of evolvability and its profound importance for understanding and ap- plying biology. What is evolvability - how would you define it? Marc Kirschner In some sort of tautological way evolvability is simply the capacity of a system to evolve. But more than that, in a Darwinian sense it speaks to both the amount of effectively what I mean is that if you make random variation that is subject to selection, and the nature of changes in mechanical systems they inevitably either that variation. -
Marc Corrales Berjano
Text in context: Chromatin effects in gene regulation Marc Corrales Berjano TESI DOCTORAL UPF / 2017 DIRECTOR DE LA TESI Dr. Guillaume Filion DEPARTAMENT Gene Regulation, Stem cells and Cancer Genome architecture Center for Genomic Regulation (CRG) ii a mi familia, iii Aknowledgements I want to thank the members of the doctoral board, present and substitutes, for accepting to analize my work and defend my thesis. I also want to thank my thesis commitee Dr. Miguel Beato, Dr. Jordi Garcia-Ojalvo and Dr. Tanya Vavouri for guidance and valuable scientific imput whenever I needed it along these years. I want to thank my mentor Dr. Guillaume Filion, not only for giving me the opportunity to carry this work in a wonderful environement, but for teaching me. No matter the tigh schedule he has allowed me to sit by his side (literally) reviewing a script at the computer, calculating the probaility of plasmid recircularization or deriving a statistical formula at the white board but also helping me to prepare and electroporate a bacterial library in what seemed a contraction of space-time. I want to thank the community of the CRG, always ready to discuss science and life in the corridors, the data seminars, symposiums, the beer sessions or following a mail asking for advice or materials. People at the administration helped enormously to navigate the tortuous bureaucratic world, maximizing the time one can dedicate toscience. ¡Dónde estaría yo sin tu puerta siempre abierta, Imma, madre en funciones de todo phD student! I want to thank the CRG for funding my phD and for constituting what I envisage as the perfect environment to learn to be a scientist. -
2019 Annual Report
BECKMAN CENTER 279 Campus Drive West Stanford, CA 94305 650.723.8423 Stanford University | Beckman Center 2019 Annual Report Annual 2019 | Beckman Center University Stanford beckman.stanford.edu 2019 ANNUAL REPORT ARNOLD AND MABEL BECKMAN CENTER FOR MOLECULAR AND GENETIC MEDICINE 30 Years of Innovation, Discovery, and Leadership in the Life Sciences CREDITS: Cover Design: Neil Murphy, Ghostdog Design Graphic Design: Jack Lem, AlphaGraphics Mountain View Photography: Justin Lewis Beckman Center Director Photo: Christine Baker, Lotus Pod Designs MESSAGE FROM THE DIRECTOR Dear Friends and Trustees, It has been 30 years since the Beckman Center for Molecular and Genetic Medicine at Stanford University School of Medicine opened its doors in 1989. The number of translational scientific discoveries and technological innovations derived from the center’s research labs over the course of the past three decades has been remarkable. Equally remarkable have been the number of scientific awards and honors, including Nobel prizes, received by Beckman faculty and the number of young scientists mentored by Beckman faculty who have gone on to prominent positions in academia, bio-technology and related fields. This year we include several featured articles on these accomplishments. In the field of translational medicine, these discoveries range from the causes of skin, bladder and other cancers, to the identification of human stem cells, from the design of new antifungals and antibiotics to the molecular underpinnings of autism, and from opioids for pain -
The Drosophila MCPH1-B Isoform Is a Substrate of the APC E3 Ubiquitin Ligase Complex
ß 2014. Published by The Company of Biologists Ltd | Biology Open (2014) 3, 669–676 doi:10.1242/bio.20148318 RESEARCH ARTICLE The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex Sarah G. Hainline`, Jamie L. Rickmyre`,*, Leif R. Neitzel, Laura A. Lee§ and Ethan Lee§ ABSTRACT and two primary co-activators, Cdc20 and Cdh1 (Kulkarni et al., 2013). Destruction of APC substrates is required in eukaryotes for The Anaphase-Promoting Complex (APC) is a multi-subunit E3 the initiation of anaphase and exit from mitosis. Cdc20 associates ubiquitin ligase that coordinates progression through the cell cycle by with the APC in early mitosis, leading to the destruction of temporally and spatially promoting the degradation of key proteins. proteins that control the onset of anaphase, whereas Cdh1 Many of these targeted proteins have been shown to play important promotes degradation of APC substrates that control late mitosis roles in regulating orderly progression through the cell cycle. Using and the following G1 phase. These co-activators provide APC a previously described Drosophila in vitro expression cloning substrate specificity by facilitating the recognition of specific approach, we screened for new substrates of the APC in Xenopus destruction motifs (e.g. degrons) such as the D-box (RxxLxxxxN) egg extract and identified Drosophila MCPH1 (dMCPH1), a protein or KEN box (Lys–Glu–Asn) (King et al., 1996; Min and Lindon, encoded by the homolog of a causative gene for autosomal recessive 2012; Pfleger and Kirschner, 2000). Mutations of these motifs primary microcephaly in humans. The dMCPH1-B splice form, but not block the recognition of the protein by the APC, preventing their the dMCPH1-C splice form, undergoes robust degradation in APC-mediated destruction. -
Chemistry NEWSLETTER
University of Michigan DEPARTMENT OF Chemistry NEWSLETTER Letter from the Chair Greetings from Ann Arbor and the chemical biology. In addition to these that Jim has done. He will be replaced by Department of Chemistry. After one full two outstanding senior hires, we welcome Professor Masato Koreeda. Professor year as Department Chair, I have come to Dr. Larry Beck from Cal Tech as the Dow Mark Meyerhoff will continue as Associ- realize the full scope of this administra- CorningAssistant Professor of analytical ate Chair for Graduate Student Affairs for tive challenge. It’s been a very busy and chemistry in September. Larry brings a another year after which he will take a exciting year as we forge ahead to meet broad spectrum of research expertise in well deserved sabbatical leave. the goals and implement the plans set out solid state NMR, zeolites and We have had another excellent year for in our new 5-year plan. nanostructures. Faculty recruiting will recruiting graduate students. In the fall, One of the most ambitious parts of our continue at a vigorous pace in the coming 45 new Ph.D. students will join the De- plan is the recruitment of new faculty at year with no less than four searches in the partment. This summer has also been a the senior and junior levels. During the area of theoretical physical chemistry, very productive one for undergraduate past year, Professor William Roush organic and chemical biology and inor- research participation with a total of 20 settled in the Department as the first ganic/materials chemistry. -
Deptbiochemistry00ruttrich.Pdf
'Berkeley University o'f California Regional Oral History Office UCSF Oral History Program The Bancroft Library Department of the History of Health Sciences University of California, Berkeley University of California, San Francisco The UCSF Oral History Program and The Program in the History of the Biological Sciences and Biotechnology William J. Rutter, Ph.D. THE DEPARTMENT OF BIOCHEMISTRY AND THE MOLECULAR APPROACH TO BIOMEDICINE AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO VOLUME I With an Introduction by Lloyd H. Smith, Jr., M.D. Interviews by Sally Smith Hughes, Ph.D. in 1992 Copyright O 1998 by the Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. -
Sugar Coated Sugar Has Become Notorious, with Countless Claims of Its Ill Effects on Health
HHMI BULLETIN N OV . ’11 VOL.24 • NO.04 • 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 Hughes Medical Institute Howard www.hhmi.org Address Service Requested Sugar Coated Sugar has become notorious, with countless claims of its ill effects on health. But not all sugars are bad for you. Consider fucose, an essential sugar the body needs. Without it, neurons can’t communicate, kidneys can’t filter blood, and skin can’t stay hydrated. Chemical biologist Carolyn • Bertozzi and her group are trying to learn more about the role of fucose in www.hhmi.org development. To do this, they injected modified versions of fucose into live, single-celled zebrafish embryos. As the embryos developed, the altered fucose molecules were incorporated into the sugars that coat cell surfaces. Using a simple chemical reaction, the team attached a labeled probe molecule to the altered fucose so they could visualize its location in the developing embryo. In this image of a 19-hour-old zebrafish embryo, labeled fucose (red) glows in the peripheral cells. Just one of many ways chemistry is helping answer biological questions (see “Living Chemistry,” page 12). YEAR OF CHEMISTRY Chemists fascinated by the complexity of biology are solving problems in neuroscience, immunology, and cell signaling. v ol. 24 / no. no. / Karen Dehnert and Scott Laughlin / Bertozzi lab In This Issue: Traveling Microscope / Lemur vs Mouse / Spotlight on Science Teacher Training 04 ObservatiOns ThE GIvInG TREE The history of science overflows with captivating stories of break- Johann Kraut in 1869 and Hermann Kolbe in 1874, but then, unfortunately, throughs that led to innovative disease treatments. -
William E. Mahoney Annual Lecture in Chemistry
ILLIAM E. MAHONEY OBERT M. MAHONEY Wis a 1955 alumnus of the Department of Chemistry at is President and Chief R the University of Massachusetts, Executive Officer of Belmont Amherst. Professor Mahoney was Savings Bank. Vice Chairman and Chief Operating Mahoney received his M.B.A. Officer, as well as Chairman of the from Columbia Business School Executive Committee of the Board of in 1971. He is a 1970 graduate of Directors, of Witco Corporation (now Chemtura Corporation), a Fortune 500 manufacturer of the University of Massachusetts, specialty chemical and petroleum products. where he earned a Bachelor of Science degree in Chemistry. He received the 1996 After retiring from Witco in 1996, Professor Mahoney diverted Distinguished Alumnus Award from the University of his energies to developing the next generation of leadership Massachusetts, and the 2006 Columbia University in science and industry. Professor Mahoney was a longtime School of Business Leadership Award. He is the recipient adjunct faculty member in the UMass Chemistry Department. of the 2009 Henry L. Shattuck Boston City Champion He taught a highly successful seminar series entitled “The Award and the 2011 USS Constitution Museum’s Charles Business of Science: Contemporary Practices” for several Francis Adams Award for public service. years. Through this seminar series, students were introduced In February 2014, Mahoney was named the “most- to topics in the management of science and technology by speakers from the business management communities. admired CEO of a small or mid-sized company in Professor Mahoney also chaired the Natural Sciences William E. Mahoney Massachusetts” by the Boston Business Journal. -
Trouble with Testosterone Test
Trouble with testosterone test Annual Meeting Special Section CONTENTS NEWS FEATURES PERSPECTIVES 2 14 36 EDITOR’S NOTE THE TROUBLE WITH PUBLIC AFFAIRS It’s time THE TESTOSTERONE TEST Are postdocs still invisible? 3 18 38 PRESIDENT’S MESSAGE MASTERS OF PHYSIOLOGY MINORITY AFFAIRS Celebrating serendipity 38 Exemplifying Sewer’s commitment to diversity 22 40 Diversifying the scientic 4 THE 2017 ANNUAL MEETING NEWS FROM THE HILL workforce with IMAGE 23 Expand your scientic horizons A lot at stake 42 Cultivating a focus on diversity 29 e spotlight is on you as a community 30 Promoting lifelong learning 5 34 Advance your careers, grad students MEMBER UPDATE 44 and postdocs! TRANSITIONS 35 Reminders for the 2017 ASBMB 7 Undergraduate Poster Competition Wrestling with life RETROSPECTIVE 7 Roscoe Owen Brady (1923–2016) 14 48 9 Roger Tsien (1952–2016) Experts are OPEN CHANNELS grappling with what constitutes 10 high testosterone 42 blood levels in elite NEWS track and eld Blind wins Tabor award women athletes. for work on nuclear lipids 11 JOURNAL NEWS 11 Blocking potato blight’s ability 22 to set up shop 12 Infant gut microbes’ thirst for milk proteins 13 How a single-cell marine organism makes fatty acids 12 44 TRANSITION STATES NOVEMBER 2016 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s time By Angela Hopp OFFICERS COUNCIL MEMBERS Natalie Ahn Squire J. Booker President Victoria J. DeRose Wayne Fairbrother. recently saw a documen- Ben Corb, in his “News Steven McKnight Karen G. Fleming tary on Netix about from the Hill” column, Past President Rachel Green uncontacted tribes in writes about the count- Jennifer DuBois Susan Marqusee I Secretary Jared Rutter the rainforest on the border down to a new American Celia A. -
Interpretation: Hemichordates May Have No “Notochord”
iBioSeminars: Marc Kirschner, March 2008 The Origin of Vertebrates, Part 3 Part 3. How did the Chordate get its chord (notochord)? Marc Kirschner Dept. of Systems Biology Harvard Medical School Boston Massachusetts The Spemann experiment and the vertebrate specific development What about the notochord? Interpretation: Hemichordates • The crux of Bateson’s argument that hemichordates were essentially chordates. may have no “notochord”. • Virtually every marker of the vertebrate notochord is present in the hemichordate (chordin, noggin, admp, brachyury, hedgehog….) • Small problem, they are not in the hemichordate stromachord. The American Society for Cell Biology 1 iBioSeminars: Marc Kirschner, March 2008 The Origin of Vertebrates, Part 3 But does it have a Spemann Organizer? Though the organizer gives rise to the notochord in vertebrates, it is in fact also a complex signaling center. The hemichordate expresses genes of the chordate prechordal endo-mesoderm (otx, dmbx, ttf2, hex, gsc…), and at the appropriate A/P map position. ttf2/foxE2 dmbx Interpretation: as a signaling center, the hemichordate has an organizer otx The vertebrate organizer is a tripartite structure of signaling centers The American Society for Cell Biology 2 iBioSeminars: Marc Kirschner, March 2008 The Origin of Vertebrates, Part 3 But these organizer signaling centers are initially dispersed in hemichordates The vertebrate organizer is a composit of three distinct signaling centers in hemichordates • The vertebrate organizer is complex, since it conflates dorsal/ventral -
BIOLOGY 639 SCIENCE ONLINE the Unexpected Brains Behind Blood Vessel Growth 641 THIS WEEK in SCIENCE 668 U.K
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The Invention of Courts the Unstable Biomedical Research Ecosystem
american academy of arts & sciences spring 2015 www.amacad.org vol. lxviii, no. 3 american academy of arts & sciences bulletin spring 2015 Bulletin Academy Report Explores the State of the Humanities in Higher Education The Invention of Courts Jamal Greene, Carol S. Steiker, Susan S. Silbey, Linda Greenhouse, Jonathan Lippman, and Judith Resnik The Unstable Biomedical Research Ecosystem: How Can It Be Made More Robust? Mark C. Fishman, Nancy C. Andrews, Sally Kornbluth, Susan R. Wente, Richard H. Brodhead, Harold Varmus, and Tania Baker ALSO: Replenishing the Innovation Pipeline: The Role of University Research Mr g–The Story of Creation as Told by God Policy Perspective on the Police Use of Lethal Force On the Professions In Memoriam: David Frohnmayer Upcoming Events JUNE NOVEMBER 15th 17th Washington, DC Cambridge, MA The Ritz-Carlton Georgetown House of the Academy Reception for Washington, DC, Chamber Series Area Fellows and Guests in collaboration with the Welcome Newly Elected Fellows Cantata Singers Made in America: Songs by Barber, OCTOBER Copland, and Fine 9th–11th Cambridge, MA Induction Weekend 9th A Celebration of the Arts and Humanities 10th Induction Ceremony 11th Academic Symposium For updates and additions to the calendar, visit www.amacad.org. Special Thanks e recently completed another successful fund-raising year with more than W$6.7 million raised. The Annual Fund surpassed $1.7 million, a record-break- ing total. Gifts from all other sources–including grants for projects–totaled more than $5 million. We are grateful for the generosity of an increasing number of contributors–including members, staff, and friends; foundations, corporations, and associations; and Univer- sity Affiliates–who made these results possible.