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Marc Corrales Berjano
Text in context: Chromatin effects in gene regulation Marc Corrales Berjano TESI DOCTORAL UPF / 2017 DIRECTOR DE LA TESI Dr. Guillaume Filion DEPARTAMENT Gene Regulation, Stem cells and Cancer Genome architecture Center for Genomic Regulation (CRG) ii a mi familia, iii Aknowledgements I want to thank the members of the doctoral board, present and substitutes, for accepting to analize my work and defend my thesis. I also want to thank my thesis commitee Dr. Miguel Beato, Dr. Jordi Garcia-Ojalvo and Dr. Tanya Vavouri for guidance and valuable scientific imput whenever I needed it along these years. I want to thank my mentor Dr. Guillaume Filion, not only for giving me the opportunity to carry this work in a wonderful environement, but for teaching me. No matter the tigh schedule he has allowed me to sit by his side (literally) reviewing a script at the computer, calculating the probaility of plasmid recircularization or deriving a statistical formula at the white board but also helping me to prepare and electroporate a bacterial library in what seemed a contraction of space-time. I want to thank the community of the CRG, always ready to discuss science and life in the corridors, the data seminars, symposiums, the beer sessions or following a mail asking for advice or materials. People at the administration helped enormously to navigate the tortuous bureaucratic world, maximizing the time one can dedicate toscience. ¡Dónde estaría yo sin tu puerta siempre abierta, Imma, madre en funciones de todo phD student! I want to thank the CRG for funding my phD and for constituting what I envisage as the perfect environment to learn to be a scientist. -
2019 Annual Report
BECKMAN CENTER 279 Campus Drive West Stanford, CA 94305 650.723.8423 Stanford University | Beckman Center 2019 Annual Report Annual 2019 | Beckman Center University Stanford beckman.stanford.edu 2019 ANNUAL REPORT ARNOLD AND MABEL BECKMAN CENTER FOR MOLECULAR AND GENETIC MEDICINE 30 Years of Innovation, Discovery, and Leadership in the Life Sciences CREDITS: Cover Design: Neil Murphy, Ghostdog Design Graphic Design: Jack Lem, AlphaGraphics Mountain View Photography: Justin Lewis Beckman Center Director Photo: Christine Baker, Lotus Pod Designs MESSAGE FROM THE DIRECTOR Dear Friends and Trustees, It has been 30 years since the Beckman Center for Molecular and Genetic Medicine at Stanford University School of Medicine opened its doors in 1989. The number of translational scientific discoveries and technological innovations derived from the center’s research labs over the course of the past three decades has been remarkable. Equally remarkable have been the number of scientific awards and honors, including Nobel prizes, received by Beckman faculty and the number of young scientists mentored by Beckman faculty who have gone on to prominent positions in academia, bio-technology and related fields. This year we include several featured articles on these accomplishments. In the field of translational medicine, these discoveries range from the causes of skin, bladder and other cancers, to the identification of human stem cells, from the design of new antifungals and antibiotics to the molecular underpinnings of autism, and from opioids for pain -
Sugar Coated Sugar Has Become Notorious, with Countless Claims of Its Ill Effects on Health
HHMI BULLETIN N OV . ’11 VOL.24 • NO.04 • 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 Hughes Medical Institute Howard www.hhmi.org Address Service Requested Sugar Coated Sugar has become notorious, with countless claims of its ill effects on health. But not all sugars are bad for you. Consider fucose, an essential sugar the body needs. Without it, neurons can’t communicate, kidneys can’t filter blood, and skin can’t stay hydrated. Chemical biologist Carolyn • Bertozzi and her group are trying to learn more about the role of fucose in www.hhmi.org development. To do this, they injected modified versions of fucose into live, single-celled zebrafish embryos. As the embryos developed, the altered fucose molecules were incorporated into the sugars that coat cell surfaces. Using a simple chemical reaction, the team attached a labeled probe molecule to the altered fucose so they could visualize its location in the developing embryo. In this image of a 19-hour-old zebrafish embryo, labeled fucose (red) glows in the peripheral cells. Just one of many ways chemistry is helping answer biological questions (see “Living Chemistry,” page 12). YEAR OF CHEMISTRY Chemists fascinated by the complexity of biology are solving problems in neuroscience, immunology, and cell signaling. v ol. 24 / no. no. / Karen Dehnert and Scott Laughlin / Bertozzi lab In This Issue: Traveling Microscope / Lemur vs Mouse / Spotlight on Science Teacher Training 04 ObservatiOns ThE GIvInG TREE The history of science overflows with captivating stories of break- Johann Kraut in 1869 and Hermann Kolbe in 1874, but then, unfortunately, throughs that led to innovative disease treatments. -
William E. Mahoney Annual Lecture in Chemistry
ILLIAM E. MAHONEY OBERT M. MAHONEY Wis a 1955 alumnus of the Department of Chemistry at is President and Chief R the University of Massachusetts, Executive Officer of Belmont Amherst. Professor Mahoney was Savings Bank. Vice Chairman and Chief Operating Mahoney received his M.B.A. Officer, as well as Chairman of the from Columbia Business School Executive Committee of the Board of in 1971. He is a 1970 graduate of Directors, of Witco Corporation (now Chemtura Corporation), a Fortune 500 manufacturer of the University of Massachusetts, specialty chemical and petroleum products. where he earned a Bachelor of Science degree in Chemistry. He received the 1996 After retiring from Witco in 1996, Professor Mahoney diverted Distinguished Alumnus Award from the University of his energies to developing the next generation of leadership Massachusetts, and the 2006 Columbia University in science and industry. Professor Mahoney was a longtime School of Business Leadership Award. He is the recipient adjunct faculty member in the UMass Chemistry Department. of the 2009 Henry L. Shattuck Boston City Champion He taught a highly successful seminar series entitled “The Award and the 2011 USS Constitution Museum’s Charles Business of Science: Contemporary Practices” for several Francis Adams Award for public service. years. Through this seminar series, students were introduced In February 2014, Mahoney was named the “most- to topics in the management of science and technology by speakers from the business management communities. admired CEO of a small or mid-sized company in Professor Mahoney also chaired the Natural Sciences William E. Mahoney Massachusetts” by the Boston Business Journal. -
Two Hundred and Twenty-Second Commencement for the Conferring of Degrees
UNIVERSITY of PENNSYLVANIA Two Hundred and Twenty-Second Commencement for the Conferring of Degrees PHILADELPHIA CIVIC CENTER CONVENTION HALL Monday, May 22, 1978 10:00 A.M. Guests will find this diagram helpful in locating in the Contents on the opposite page under Degrees the approximate seating of the degree candidates. in Course. Reference to the paragraph on page The seating roughly corresponds to the order by seven describing the colors of the candidates school in which the candidates for degrees are hoods according to their fields of study may further presented, beginning at top left with the Faculty of assist guests in placing the locations of the various Arts and Sciences. The actual sequence is shown schools. Contents Page Seating Diagram of the Graduating Students 2 The Commencement Ceremony 4 Commencement Notes 6 Degrees in Course 8 The Faculty of Arts and Sciences 8 The College of General Studies 16 The College of Engineering and Applied Science 17 The Wharton School 23 The Wharton Evening School 27 The Wharton Graduate Division 28 The School of Nursing 33 The School of Allied Medical Professions 35 The Graduate Faculties 36 The School of Medicine 41 The Law School 42 The Graduate School of Fine Arts 44 The School of Dental Medicine 47 The School of Veterinary Medicine 48 The Graduate School of Education 49 The School of Social Work 51 The Annenberg School of Communications 52 Certificates 53 General Honors Program 53 Medical Technology 53 Occupational Therapy 54 Physical Therapy 56 Dental Hygiene 57 Advanced Dental Education 57 Social Work 58 Commissions 59 Army 59 Navy 60 Principal Undergraduate Academic Honor Societies 61 Prizes and Awards 64 Class of 1928 69 Events Following Commencement 71 The Commencement Marshals 72 Academic Honors Insert The Commencement Ceremony MUSIC Valley Forge Military Academy and Junior College Band CAPTAIN JAMES M. -
Digital Object, Digital Subjects
DIGITAL OBJECTS DIGITAL SUBJECTS Interdisciplinary Perspectives on Capitalism, Labour and Politics in the Age of Big Data Edited by DAVID CHANDLER and CHRISTIAN FUCHS Digital Objects, Digital Subjects: Interdisciplinary Perspectives on Capitalism, Labour and Politics in the Age of Big Data Edited by David Chandler and Christian Fuchs University of Westminster Press www.uwestminsterpress.co.uk Published by University of Westminster Press 101 Cavendish Street London W1W 6UW www.uwestminsterpress.co.uk Text ©the editors and several contributors 2019 First published 2019 Cover: Diana Jarvis Printed in the UK by Lightning Source Ltd. Print and digital versions typeset by Siliconchips Services Ltd. ISBN (Hardback): 978-1-912656-08-0 ISBN (PDF): 978-1-912656-09-7 ISBN (EPUB): 978-1-912656-10-3 ISBN (Kindle): 978-1-912656-11-0 ISBN (Paperback): 978-1-912656-20-2 DOI: https://doi.org/10.16997/book29 This work is licensed under the Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA. This license allows for copying and distributing the work, providing author attribution is clearly stated, that you are not using the material for commercial purposes, and that modified versions are not distributed. The full text of this book has been peer-reviewed to ensure high academic standards. For full review policies, see: http://www.uwestminsterpress.co.uk/ site/publish. Competing Interests: the editors and contributors declare that they have no competing interests in publishing this book Suggested citation: Chandler, D. -
Vida Cotidiana Durante La Revolución Mexicana Alejandro Rodriguez-Mayoral University of Texas at El Paso, Alejandro [email protected]
University of Texas at El Paso DigitalCommons@UTEP Open Access Theses & Dissertations 2015-01-01 Zapatistas: Vida cotidiana durante la Revolución Mexicana Alejandro Rodriguez-Mayoral University of Texas at El Paso, [email protected] Follow this and additional works at: https://digitalcommons.utep.edu/open_etd Part of the Latin American History Commons Recommended Citation Rodriguez-Mayoral, Alejandro, "Zapatistas: Vida cotidiana durante la Revolución Mexicana" (2015). Open Access Theses & Dissertations. 1138. https://digitalcommons.utep.edu/open_etd/1138 This is brought to you for free and open access by DigitalCommons@UTEP. It has been accepted for inclusion in Open Access Theses & Dissertations by an authorized administrator of DigitalCommons@UTEP. For more information, please contact [email protected]. ZAPATISTAS: VIDA COTIDIANA DURANTE LA REVOLUCIÓN MEXICANA ALEJANDRO RODRIGUEZ-MAYORAL Departamento de Historia APROBADO: Samuel Brunk, Ph.D., Chair Yolanda Chávez Leyva, Ph.D. Sandra McGee Deutsch, Ph.D. Howard Campbell, Ph.D. Charles Ambler, Ph.D. Dean of the Graduate School Copyright © por Alejandro Rodriguez-Mayoral 2015 Dedicatoria Dedico esta disertación a Dios. ZAPATISTAS: VIDA COTIDIANA DURANTE LA REVOLUCIÓN MEXICANA por ALEJANDRO RODRIGUEZ-MAYORAL, Máster DISERTACIÓN Presentada a la facultad de la Escuela de Graduados de la Universidad de Texas en El Paso en cumplimiento parcial de los requerimientos para el Grado de DOCTOR Departamento de Historia UNIVERSIDAD DE TEXAS EN EL PASO Mayo 2015 AGRADECIMIENTOS Esta tesis doctoral fue escrita con el apoyo incondicional de amigos, familiares y profesores durante mi preparación académica, proceso de investigación y escritura de la misma. Deseo hacer presente mi gratitud a Servando Ortoll, Avital Bloch, Charles Ambler, Cheryl E. -
Trouble with Testosterone Test
Trouble with testosterone test Annual Meeting Special Section CONTENTS NEWS FEATURES PERSPECTIVES 2 14 36 EDITOR’S NOTE THE TROUBLE WITH PUBLIC AFFAIRS It’s time THE TESTOSTERONE TEST Are postdocs still invisible? 3 18 38 PRESIDENT’S MESSAGE MASTERS OF PHYSIOLOGY MINORITY AFFAIRS Celebrating serendipity 38 Exemplifying Sewer’s commitment to diversity 22 40 Diversifying the scientic 4 THE 2017 ANNUAL MEETING NEWS FROM THE HILL workforce with IMAGE 23 Expand your scientic horizons A lot at stake 42 Cultivating a focus on diversity 29 e spotlight is on you as a community 30 Promoting lifelong learning 5 34 Advance your careers, grad students MEMBER UPDATE 44 and postdocs! TRANSITIONS 35 Reminders for the 2017 ASBMB 7 Undergraduate Poster Competition Wrestling with life RETROSPECTIVE 7 Roscoe Owen Brady (1923–2016) 14 48 9 Roger Tsien (1952–2016) Experts are OPEN CHANNELS grappling with what constitutes 10 high testosterone 42 blood levels in elite NEWS track and eld Blind wins Tabor award women athletes. for work on nuclear lipids 11 JOURNAL NEWS 11 Blocking potato blight’s ability 22 to set up shop 12 Infant gut microbes’ thirst for milk proteins 13 How a single-cell marine organism makes fatty acids 12 44 TRANSITION STATES NOVEMBER 2016 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s time By Angela Hopp OFFICERS COUNCIL MEMBERS Natalie Ahn Squire J. Booker President Victoria J. DeRose Wayne Fairbrother. recently saw a documen- Ben Corb, in his “News Steven McKnight Karen G. Fleming tary on Netix about from the Hill” column, Past President Rachel Green uncontacted tribes in writes about the count- Jennifer DuBois Susan Marqusee I Secretary Jared Rutter the rainforest on the border down to a new American Celia A. -
Worlds Apart: How the Distance Between Science and Journalism Threatens America's Future
Worlds Apart Worlds Apart HOW THE DISTANCE BETWEEN SCIENCE AND JOURNALISM THREATENS AMERICA’S FUTURE JIM HARTZ AND RICK CHAPPELL, PH.D. iv Worlds Apart: How the Distance Between Science and Journalism Threatens America’s Future By Jim Hartz and Rick Chappell, Ph.D. ©1997 First Amendment Center 1207 18th Avenue South Nashville, TN 37212 (615) 321-9588 www.freedomforum.org Editor: Natilee Duning Designer: David Smith Publication: #98-F02 To order: 1-800-830-3733 Contents Foreword vii Scientists Needn’t Take Themselves Seriously To Do Serious Science 39 Introduction ix Concise writing 40 Talk to the customers 41 Overview xi An end to infighting 42 The incremental nature of science 43 The Unscientific Americans 1 Scientific Publishing 44 Serious omissions 2 Science and the Fourth Estate 47 The U.S. science establishment 4 Public disillusionment 48 Looking ahead at falling behind 5 Spreading tabloidization 48 Out of sight, out of money 7 v Is anybody there? 8 Unprepared but interested 50 The regional press 50 The 7 Percent Solution 10 The good science reporter 51 Common Denominators 13 Hooked on science 52 Gauging the Importance of Science 53 Unfriendly assessments 13 When tortoise meets hare 14 Media Gatekeepers 55 Language barriers 15 Margin of error 16 The current agenda 55 Objective vs. subjective 17 Not enough interest 57 Gatekeepers as obstacles 58 Changing times, concurrent threats 17 What does the public want? 19 Nothing Succeeds Like Substance 60 A new interest in interaction 20 Running Scared 61 Dams, Diversions & Bottlenecks 21 Meanwhile, -
BIOLOGY 639 SCIENCE ONLINE the Unexpected Brains Behind Blood Vessel Growth 641 THIS WEEK in SCIENCE 668 U.K
4 February 2005 Vol. 307 No. 5710 Pages 629–796 $10 07%.'+%#%+& 2416'+0(70%6+10 37#06+6#6+8' 51(69#4' #/2.+(+%#6+10 %'..$+1.1); %.10+0) /+%41#44#;5 #0#.;5+5 #0#.;5+5 2%4 51.76+105 Finish first with a superior species. 50% faster real-time results with FullVelocity™ QPCR Kits! Our FullVelocity™ master mixes use a novel enzyme species to deliver Superior Performance vs. Taq -Based Reagents FullVelocity™ Taq -Based real-time results faster than conventional reagents. With a simple change Reagent Kits Reagent Kits Enzyme species High-speed Thermus to the thermal profile on your existing real-time PCR system, the archaeal Fast time to results FullVelocity technology provides you high-speed amplification without Enzyme thermostability dUTP incorporation requiring any special equipment or re-optimization. SYBR® Green tolerance Price per reaction $$$ • Fast, economical • Efficient, specific and • Probe and SYBR® results sensitive Green chemistries Need More Information? Give Us A Call: Ask Us About These Great Products: Stratagene USA and Canada Stratagene Europe FullVelocity™ QPCR Master Mix* 600561 Order: (800) 424-5444 x3 Order: 00800-7000-7000 FullVelocity™ QRT-PCR Master Mix* 600562 Technical Services: (800) 894-1304 Technical Services: 00800-7400-7400 FullVelocity™ SYBR® Green QPCR Master Mix 600581 FullVelocity™ SYBR® Green QRT-PCR Master Mix 600582 Stratagene Japan K.K. *U.S. Patent Nos. 6,528,254, 6,548,250, and patents pending. Order: 03-5159-2060 Purchase of these products is accompanied by a license to use them in the Polymerase Chain Reaction (PCR) Technical Services: 03-5159-2070 process in conjunction with a thermal cycler whose use in the automated performance of the PCR process is YYYUVTCVCIGPGEQO covered by the up-front license fee, either by payment to Applied Biosystems or as purchased, i.e., an authorized thermal cycler. -
Characterization of Developmental and Molecular Factors Underlying Release Heterogeneity at Drosophila Synapses
Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Akbergenova, Yulia, Karen L Cunningham, Yao V Zhang, Shirley Weiss, and J Troy Littleton. “Characterization of Developmental and Molecular Factors Underlying Release Heterogeneity at Drosophila Synapses.” eLife 7 (July 10, 2018). As Published http://dx.doi.org/10.7554/eLife.38268 Publisher eLife Sciences Publications, Ltd. Version Final published version Citable link http://hdl.handle.net/1721.1/117634 Terms of Use Creative Commons Attribution 4.0 International License Detailed Terms http://creativecommons.org/licenses/by/4.0/ RESEARCH ARTICLE Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses Yulia Akbergenova1,2,3*, Karen L Cunningham1,2, Yao V Zhang1,2,3, Shirley Weiss1,2,3, J Troy Littleton1,2,3* 1The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States; 2Department of Biology, Massachusetts Institute of Technology, Cambridge, United States; 3Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States Abstract Neurons communicate through neurotransmitter release at specialized synaptic regions known as active zones (AZs). Using biosensors to visualize single synaptic vesicle fusion events at Drosophila neuromuscular junctions, we analyzed the developmental and molecular determinants of release probability (Pr) for a defined connection with ~300 AZs. Pr was heterogeneous but represented a stable feature of each AZ. Pr remained stable during high frequency stimulation and retained heterogeneity in mutants lacking the Ca2+ sensor 2+ 2+ Synaptotagmin 1. -
Michel Foucault Ronald C Kessler Graham Colditz Sigmund Freud
ANK RESEARCHER ORGANIZATION H INDEX CITATIONS 1 Michel Foucault Collège de France 296 1026230 2 Ronald C Kessler Harvard University 289 392494 3 Graham Colditz Washington University in St Louis 288 316548 4 Sigmund Freud University of Vienna 284 552109 Brigham and Women's Hospital 5 284 332728 JoAnn E Manson Harvard Medical School 6 Shizuo Akira Osaka University 276 362588 Centre de Sociologie Européenne; 7 274 771039 Pierre Bourdieu Collège de France Massachusetts Institute of Technology 8 273 308874 Robert Langer MIT 9 Eric Lander Broad Institute Harvard MIT 272 454569 10 Bert Vogelstein Johns Hopkins University 270 410260 Brigham and Women's Hospital 11 267 363862 Eugene Braunwald Harvard Medical School Ecole Polytechnique Fédérale de 12 264 364838 Michael Graetzel Lausanne 13 Frank B Hu Harvard University 256 307111 14 Yi Hwa Liu Yale University 255 332019 15 M A Caligiuri City of Hope National Medical Center 253 345173 16 Gordon Guyatt McMaster University 252 284725 17 Salim Yusuf McMaster University 250 357419 18 Michael Karin University of California San Diego 250 273000 Yale University; Howard Hughes 19 244 221895 Richard A Flavell Medical Institute 20 T W Robbins University of Cambridge 239 180615 21 Zhong Lin Wang Georgia Institute of Technology 238 234085 22 Martín Heidegger Universität Freiburg 234 335652 23 Paul M Ridker Harvard Medical School 234 318801 24 Daniel Levy National Institutes of Health NIH 232 286694 25 Guido Kroemer INSERM 231 240372 26 Steven A Rosenberg National Institutes of Health NIH 231 224154 Max Planck