The Invention of Courts the Unstable Biomedical Research Ecosystem
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1999 Annual Report
1999 1999 BANBURY CENTER DIRECTOR'S REPORT The Banbury Center program continues to be as eclectic and exciting as ever. The year was filled with more meetings than ever before-a record 23 of them! Laboratory scientists used the Center for seven in-house meetings, and local community groups came here on eight occasions. Together with the five neurobiology courses, there was hardly a week when the Center was not in use. Not surprisingly, 1999 was also a record year for the number of visitors to Banbury Center: 667 par ticipants attended the 23 meetings. The demographics of our participants remain much the same: 25% of visitors to Banbury Center came from abroad, with the United Kingdom, Germany, and Canada lead ing the way. Of the American scientists, those from New York, Massachusetts, and California together accounted for more than 32% of the total. However, participants were drawn from no fewer than 42 states. This is the first year that we have been able to use the Meier House to accommodate participants, which proved to be wonderful. Now the number of participants that we can house on the Banbury estate matches the number we can have in the Conference Room-we do not have to transport peo ple between the Center and the main campus. Biological and biomedical research is becoming ever more interdisciplinary, and as it does so, it also becomes ever more difficult to categorize the topics of Banbury Center meetings. A meeting may deal with the same phenomenon in a range of organisms, or many different strategies may be used to study one phenomenon in a single species. -
Chicago Section American Chemical
http://chicagoacs.org NOVEMBER • 2008 CHICAGO SECTION AMERICAN CHEMICAL SOCIETY Joint Meeting of the University of Chicago Department of Chemistry and the Chicago Section ACS WEDNESDAY, NOVEMBER 19, 2008 The Parthenon Restaurant Vegetarian Spinach-Cheese Pie, Vege- PRESENTATION OF STIEGLITZ 314 South Halsted Street tarian Pastitsio (Macaroni baked with LECTURE 8:00 P.M. Chicago, IL broccoli, Bechamel sauce and Kefalotiri), 312-726-2407 Dolmades (vine leaves stuffed with rice, meats and herbs), Rotisserie-roasted DIRECTIONS TO THE MEETING lamb served with rice pilaf and roasted potatoes. Desserts: Baklava (flaky layers From Kennedy (I-90) or Edens (I-94): of Phyllo baked with nuts and honey) Drive downtown and exit at Adams and Galaktobouriko (flaky layers of Phyl- Street. Turn right to Halsted. Turn left at lo with vanilla custard and baked with Halsted. Restaurant is approximately syrup. Beverages, bread and butter. 1.5 blocks on the west side of the street. The cost is $30 to Section members who From Eisenhower (I-290): Drive east have paid their local section dues, mem- to Chicago. Exit at Racine and turn left. bers' families, and visiting ACS members. Go to Jackson Boulevard and turn right. The cost to members who have NOT Take Jackson to Halsted. Turn right at paid their local section dues and to non- Halsted. Restaurant is approximately Section members is $32. The cost to stu- 1/2 block on the west side of the street. dents and unemployed members is $15. Seating will be available for those who PARKING: Free valet parking. Parking wish to attend the meeting without dinner. -
Beyond Darwin: Evolvability and the Generation of Novelty Marc Kirschner
Kirschner M BMC Biology 2013, 11:110 http://www.biomedcentral.com/1741-7007/11/110 INTERVIEW Open Access Beyond Darwin: evolvability and the generation of novelty Marc Kirschner Marc Kirschner graduated in biochemistry from North- western University, moving to Berkeley for his doctoral research and with positions at Berkeley, Oxford Univer- sity and Princeton before he took a professorship at Uni- versity of California San Francisco where with Andrew Murray he did seminal research on the control of the cell cycle in Xenopus egg extracts that led to the discov- ery of how cyclin drives the cell cycle, and with Tim Mitchison on the dynamic instability of microtubules. In 1993 he moved to Harvard where in 2003 he became the founding Chair of the HMS Department of Systems Biology and was named the John Franklin Enders Uni- versity Professor in 2009. The two books he wrote with John Gerhart, Cells, Embryos and Evolution (Blackwell, 1997) and The Plausibility of Life: Resolving Darwin’sDi- lemma (Yale University Press, 2005), reflect his deep and longstanding interest in how biological systems evolve. Here he gives his view of the evolution of evolvability and its profound importance for understanding and ap- plying biology. What is evolvability - how would you define it? Marc Kirschner In some sort of tautological way evolvability is simply the capacity of a system to evolve. But more than that, in a Darwinian sense it speaks to both the amount of effectively what I mean is that if you make random variation that is subject to selection, and the nature of changes in mechanical systems they inevitably either that variation. -
Race in the Age of Obama Making America More Competitive
american academy of arts & sciences summer 2011 www.amacad.org Bulletin vol. lxiv, no. 4 Race in the Age of Obama Gerald Early, Jeffrey B. Ferguson, Korina Jocson, and David A. Hollinger Making America More Competitive, Innovative, and Healthy Harvey V. Fineberg, Cherry A. Murray, and Charles M. Vest ALSO: Social Science and the Alternative Energy Future Philanthropy in Public Education Commission on the Humanities and Social Sciences Reflections: John Lithgow Breaking the Code Around the Country Upcoming Events Induction Weekend–Cambridge September 30– Welcome Reception for New Members October 1–Induction Ceremony October 2– Symposium: American Institutions and a Civil Society Partial List of Speakers: David Souter (Supreme Court of the United States), Maj. Gen. Gregg Martin (United States Army War College), and David M. Kennedy (Stanford University) OCTOBER NOVEMBER 25th 12th Stated Meeting–Stanford Stated Meeting–Chicago in collaboration with the Chicago Humanities Perspectives on the Future of Nuclear Power Festival after Fukushima WikiLeaks and the First Amendment Introduction: Scott D. Sagan (Stanford Introduction: John A. Katzenellenbogen University) (University of Illinois at Urbana-Champaign) Speakers: Wael Al Assad (League of Arab Speakers: Geoffrey R. Stone (University of States) and Jayantha Dhanapala (Pugwash Chicago Law School), Richard A. Posner (U.S. Conferences on Science and World Affairs) Court of Appeals for the Seventh Circuit), 27th Judith Miller (formerly of The New York Times), Stated Meeting–Berkeley and Gabriel Schoenfeld (Hudson Institute; Healing the Troubled American Economy Witherspoon Institute) Introduction: Robert J. Birgeneau (Univer- DECEMBER sity of California, Berkeley) 7th Speakers: Christina Romer (University of Stated Meeting–Stanford California, Berkeley) and David H. -
GSA Welcomes 2012 Board Members
7INTERs3PRING 4HE'3!2EPORTER winter s spring 2012 New Executive GSA Welcomes 2012 Board Members Director Now on Board The Genetics Society of America New Members of the GSA Board of welcomes four new members elected Directors Adam P. Fagen, by the general membership to the Ph.D., stepped in as 2012 GSA Board of Directors. The VICE PRESIDENT: GSA’s new Executive new members are: Michael Lynch Michael Lynch, Director beginning (Indiana University), who serves as Distinguished December 1, 2011. vice president in 2012 and as GSA Professor of Dr. Fagen previously president in 2013 and Marnie E. Biology, Class of was at the American Halpern (Carnegie Institution for 1954 Professor, Society of Plant Science); Mohamed Noor (Duke Department of Biologists (ASPB), University); and John Schimenti Biology, Indiana where he was the director of public (Cornell University), who will serve as University, continued on page nineteen directors. Bloomington. Dr. Lynch is a population and evolutionary biologist and a In addition to these elected officers, long-time member of GSA. Dr. Lynch 2012 Brenda J. Andrews (University of sees GSA as the home for geneticists Toronto), Editor-in-Chief of GSA’s who study a broad base of topics GSA Award journal, G3: Genes|Genomes|Genetics, and organisms, and as a forum Recipients which was first published online in where general discussion occurs, June 2011, becomes a member of the whether based on the principles Announced Board of Directors. The bylaws have of genetics, the most pressing historically included the GENETICS GSA is pleased to announce the issues within the discipline itself, or editor-in-chief on the Board and as a responses to societal concerns and/ 2012 recipients of its five awards result of a 2011 bylaw revision, the G3 for distinguished service in the or conflicts within applied genetics. -
The Drosophila MCPH1-B Isoform Is a Substrate of the APC E3 Ubiquitin Ligase Complex
ß 2014. Published by The Company of Biologists Ltd | Biology Open (2014) 3, 669–676 doi:10.1242/bio.20148318 RESEARCH ARTICLE The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex Sarah G. Hainline`, Jamie L. Rickmyre`,*, Leif R. Neitzel, Laura A. Lee§ and Ethan Lee§ ABSTRACT and two primary co-activators, Cdc20 and Cdh1 (Kulkarni et al., 2013). Destruction of APC substrates is required in eukaryotes for The Anaphase-Promoting Complex (APC) is a multi-subunit E3 the initiation of anaphase and exit from mitosis. Cdc20 associates ubiquitin ligase that coordinates progression through the cell cycle by with the APC in early mitosis, leading to the destruction of temporally and spatially promoting the degradation of key proteins. proteins that control the onset of anaphase, whereas Cdh1 Many of these targeted proteins have been shown to play important promotes degradation of APC substrates that control late mitosis roles in regulating orderly progression through the cell cycle. Using and the following G1 phase. These co-activators provide APC a previously described Drosophila in vitro expression cloning substrate specificity by facilitating the recognition of specific approach, we screened for new substrates of the APC in Xenopus destruction motifs (e.g. degrons) such as the D-box (RxxLxxxxN) egg extract and identified Drosophila MCPH1 (dMCPH1), a protein or KEN box (Lys–Glu–Asn) (King et al., 1996; Min and Lindon, encoded by the homolog of a causative gene for autosomal recessive 2012; Pfleger and Kirschner, 2000). Mutations of these motifs primary microcephaly in humans. The dMCPH1-B splice form, but not block the recognition of the protein by the APC, preventing their the dMCPH1-C splice form, undergoes robust degradation in APC-mediated destruction. -
Deptbiochemistry00ruttrich.Pdf
'Berkeley University o'f California Regional Oral History Office UCSF Oral History Program The Bancroft Library Department of the History of Health Sciences University of California, Berkeley University of California, San Francisco The UCSF Oral History Program and The Program in the History of the Biological Sciences and Biotechnology William J. Rutter, Ph.D. THE DEPARTMENT OF BIOCHEMISTRY AND THE MOLECULAR APPROACH TO BIOMEDICINE AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO VOLUME I With an Introduction by Lloyd H. Smith, Jr., M.D. Interviews by Sally Smith Hughes, Ph.D. in 1992 Copyright O 1998 by the Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. -
Jerrold Meinwald Wins National Medal of Science by Anne Ju [email protected]
Oct. 3, 2014 Jerrold Meinwald wins National Medal of Science By Anne Ju [email protected] Jerrold Meinwald, the Goldwin Smith Professor of Chemistry Emeritus, has received the National Medal of Science, the nation’s highest honor for achievement in science and engineering. Meinwald received the medal in chemistry; other awards were bestowed in behavioral and social sciences, biology, engineering, mathematics and physical sciences, the White House announced Oct. 3. University Photography file photo Over his long career, Meinwald, Jerrold Meinwald, the Goldwin Smith Professor of Chemistry Emeritus, has received the National Medal of Science in chemistry. who joined Cornell’s faculty in 1952 as an instructor in chemistry, has made fundamental discoveries of how chemicals act as repellants and attractants between organisms. He and the late Thomas Eisner, a longtime friend and colleague who won the National Medal of Science in 1994, are credited with establishing the feld of “chemical ecology” – the science that deals with the many ways animals, plants and microorganisms chemically interact. “It’s a very nice thing,” Meinwald said of the award. “It’s maybe a representation of a growing interest in the feld of chemical ecology.” Meinwald’s research has involved the isolation and identifcation of biologically active compounds from insect and other arthropod sources; pheromone systems of some amphibian and mammal species; and identifcation of messenger molecules involved in such systems and the understanding of underlying signal transduction pathways. Meinwald has helped decipher the intricate chemical strategies that insects use for a variety of activities: mating, location of food, protection of ofspring and defense against attackers. -
Views Expressed Are Those of the Cambridge Ma 02142
Cover_Sp2010 3/17/2010 11:30 AM Page 1 Dædalus coming up in Dædalus: the challenges of Bruce Western, Glenn Loury, Lawrence D. Bobo, Marie Gottschalk, Dædalus mass incarceration Jonathan Simon, Robert J. Sampson, Robert Weisberg, Joan Petersilia, Nicola Lacey, Candace Kruttschnitt, Loïc Wacquant, Mark Kleiman, Jeffrey Fagan, and others Journal of the American Academy of Arts & Sciences Spring 2010 the economy Robert M. Solow, Benjamin M. Friedman, Lucian A. Bebchuk, Luigi Zingales, Edward Glaeser, Charles Goodhart, Barry Eichengreen, of news Spring 2010: on the future Thomas Romer, Peter Temin, Jeremy Stein, Robert E. Hall, and others on the Loren Ghiglione Introduction 5 future Herbert J. Gans News & the news media in the digital age: the meaning of Gerald Early, Henry Louis Gates, Jr., Glenda R. Carpio, David A. of news implications for democracy 8 minority/majority Hollinger, Jeffrey B. Ferguson, Hua Hsu, Daniel Geary, Lawrence Kathleen Hall Jamieson Are there lessons for the future of news from Jackson, Farah Grif½n, Korina Jocson, Eric Sundquist, Waldo Martin, & Jeffrey A. Gottfried the 2008 presidential campaign? 18 Werner Sollors, James Alan McPherson, Robert O’Meally, Jeffrey B. Robert H. Giles New economic models for U.S. journalism 26 Perry, Clarence Walker, Wilson Jeremiah Moses, Tommie Shelby, and others Jill Abramson Sustaining quality journalism 39 Brant Houston The future of investigative journalism 45 Donald Kennedy The future of science news 57 race, inequality Lawrence D. Bobo, William Julius Wilson, Michael Klarman, Rogers Ethan Zuckerman International reporting in the age of & culture Smith, Douglas Massey, Jennifer Hochschild, Bruce Western, Martha participatory media 66 Biondi, Roland Fryer, Cathy Cohen, James Heckman, Taeku Lee, Pap Ndiaye, Marcyliena Morgan, Richard Nisbett, Jennifer Richeson, Mitchell Stephens The case for wisdom journalism–and for journalists surrendering the pursuit Daniel Sabbagh, Alford Young, Roger Waldinger, and others of news 76 Jane B. -
Download God Inside Out: Ðłñživa's Game of Dice, Don
God Inside Out: Ељiva's Game of Dice, Don Handelman, Oxford University Press, 1997, 0195108450, 9780195108453, 219 pages. This book offers a new exploration of the mythology of the Hindu god Siva, who spends his time playing dice with his wife, to whom he habitually loses. The result of the game is our world, which turns the god inside-out and changes his internal composition. Hindus maintain that Siva is perpetually absorbed in this game, which is recreated in innumerable stories, poems, paintings, and sculptural carvings. This notion of the god at play, argue Handelman and Shulman, is one of the most central and expressive veins in the metaphysics elaborated through the centuries, in many idioms and modes, around the god. The book comprises three interlocking essays; the first presents the dice-game proper, in the light of the texts and visual depictions the authors have collected. The second and third chapters take up two mythic "sequels" to the game. Based on their analysis of these sequels, the authors argue that notions of "asceticism" so frequently associated with Siva, with Yoga, and with Hindu religion are, in fact, foreign to Hinduism's inherent logic as reflected in Siva's game of dice. They suggest an alternative reading of this set of practices and ideas, providing startling new insights into Hindu mythology and the major poetic texts from the classical Sanskrit tradition.. DOWNLOAD HERE Breaking Boundaries with the Goddess New Directions in the Study of ЕљДЃktism : Essays in Honor of Narendra Nath Bhattacharyya, Cynthia Ann Humes, Rachel Fell McDermott, 2009, Shaktism, 386 pages. -
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C. Gunsalus 1912 Born in South Dakota, son of Irwin Clyde and Anna Shea Gunsalus 1935 B.S. in Bacteriology, Cornell University 1937 M.S. in Bacteriology, Cornell University 1940 Ph.D. in Bacteriology, Cornell University 1940-44 Assistant Professor of Bacteriology, Cornell University 1944-46 Associate Professor of Bacteriology, Cornell University 1946-47 Professor of Bacteriology, Cornell University 1947-50 Professor of Bacteriology, Indiana University 1949 John Simon Guggenheim Fellow 1950-55 Professor of Microbiology, University of Illinois 1955-82 Professor of Biochemistry, University of Illinois 1955-66 Head of Division of Biochemistry, University of Illinois 1959 John Simon Guggenheim Fellow 1959-60 Research sabbatical, Institut Edmund de Rothchild, Paris 1962 Patent granted for lipoic acid 1965- Member of National Academy of Sciences 1968 John Simon Guggenheim Fellow 1972-76 Member Levis Faculty Center Board of Directors 1977-78 Research sabbatical, Institut Edmund de Rothchild, Paris 1973-75 President of Levis Faculty Center Board of Directors 1978-81 Chairman of National Academy of Sciences, Section of Biochemistry 1982- Professor of Biochemistry, Emeritus, University of Illinois 1984 Honorary Doctorate, Indiana University 15/5/40 2 Box Contents List Box Contents Box Number Biographical and Personal Biographical Materials, 1967-1995 1 Personal Finances, 1961-65 1-2 Publications, Studies and Reports Journals and Reports, 1955-68 -
Performing Arts Center Moves to Next Phase with Corporate Help
Cornell Chronicle Volune 14, Number 26 Thursday, April 7, 1983 Performing Arts Center Moves to Next Phase Trustees Approve More Planning Funds The Board of Trustees approved a budget sign for the center to campus and city for the final phase of planning for the new groups and the board. Performing Arts Center at its meeting The design development phase, which March 25-26. will provide more detail of the facility than The board allocated $450,000 from gifts the first phase, is expected to be completed and commitments to the center to extend in September, Matyas explained. the planning process through design de- Subsequently, working drawings will be velopment, according to Robert M. Matyas, prepared and put out for bid by contractors vice president for facilities and business in February 1984, he continued. The time- operations. table for completion of construction is June "The board action moves us full speed 1986. ahead," Matyas said. "It will give us a Funding for the Performing Arts Center complete design for the entire project from construction now exceeds $5 million, half of the architects." the total sought for the first phase of the The firm of James Stirling, Michael project that will result in a combination Wilford and Associates of London was teaching laboratory and performance cen- selected last May by the board as ter for theater, dance and film. An addi- architects for the Performing Arts Center tional $2 million has been received for to be constructed on the southern rim of facility endowment. Cascadilla Gorge at the entrance to campus The total project is expected to cost $16.5 from the Collegetown section of Ithaca.