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May-Aug 2019 Data Retrival from Pubmed: 12 EUROPEAN SOCIETY OF ENDOCRINE SURGEONS ESES Review of Recently Published Literature Collection: T. Clerici, F. Triponez, M. Demarchi, K. Lorenz, M. Elwerr, J. Hein, L. Osmak, G. Franch-Arcas & C. Martinez-Santos Compilation and design: U. Beutner, [email protected] Affiliations see next page May-Aug 2019 Data retrival from Pubmed: 12. Dec 2019 Contents CTRL-click on category or count number jumps to the according page Publication count: SR/MA RCT CG Other Page Thyroid .............................. 9 .......... 0 ........... 0 ........ 81 ..................... 4 Parathyroids ....................... 0 .......... 2 ........... 0 ........ 23 ................... 36 Adrenals ............................. 2 .......... 1 ........... 0 ........ 26 ................... 46 NET ..................................... 1 .......... 0 ........... 0 ........ 19 ................... 58 General ............................... 1 .......... 0 ........... 0 ........ 15 ................... 66 SR: systematic review, MA: meta-analysis, RCT: randomized controlled trial, CG: consensus statement/guidelines Pubmed-ID: PubMed-Identifier (unique number for each Pubmed entry) blue underline: Hyperlink to PubMed entry or web site of publisher. Clicking on hyperlink opens the corresponding web site in browser (in Vista: CTRL-click). Collectors Thomas Clerici, MD Department of Surgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland Frédéric Triponez, MD Marco Demarchi, MD Department of Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland Kerstin Lorenz, MD Malik Elwerr Janine Hein, MD Department of General-, Visceral-, and Vascular Surgery, Martin-Luther University of Halle- Wittenberg, Germany Liliana Osmak, MD Department of Endocrine Surgery, University Hospital Dijon, Dijon, France Guzmán Franch-Arcas, MD Endocrine Surgery, Department of General and Digestive Tract Surgery, University Hospital Salamanca, Salamanca, Spain Cristina Martinez-Santos, MD Endocrine Surgery, Hospital Costa del Sol Marbella, Málaga, Spain Compilation and Coordination Ulrich Beutner, Ph.D Department of Surgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland [email protected] ESES Review of Recently Published Literature 2019-2 Page 2 of 71 Journals covered Journal IF2016 Journal IF2016 Acta Cytol 1.562† J Bone Miner Res 6.284 Am J Kidney Dis 7.623 J Clin Endocrinol Metab 5.455 Am J Nephrol 2.542 J Clin Oncol 24.008 Am J Surg 2.612 J Endocrinol 4.706 Am Surgeon 0.700 J Endocrinol Invest -- Ann Surg 8.980 J Nephrol 2.153 Ann Surg Oncol 4.041 J Nucl Med 6.646 ANZ J Surg 1.513 J Surg Oncol 2.993 Br J Surg 5.899 Lancet 47.831 Cancer 5.997 Langenbecks Arch Surg 2.203 Chirurg 0.646 Laryngoscope 2.471 Clin Endocrinol Oxf 3.327 N Engl J Med 72.406 Nat Rev Endocrinol Clin Nucl Med 3.640 18.318 (prev: Nat Clin Pract Endocrinol Metab) Nat Rev Clin Oncol Curr Opin Oncol 3.414 20.693 (prev: Nat Clin Pract Oncol) Endocr Relat Cancer 5.267 Nephrol Dial Transplant 4.470 Endocr Rev 15.745 Nephron Clin Pract 2.138 Eur Arch Otorhinolaryngol 1.660 Neuroendocrinology 3.608 Eur J Endocrinol 4.101 Oncologist 4.962 Eur J Surg Oncol 3.522 Otolaryngol Head Neck Surg 2.276 Gland Surg --- Surg Clin North Am 2.206 Head Neck 3.376 Surg Endosc 3.747 Horm Metab Res 2.268 Surg Laparosc Endosc Percutan Tech 0.938 JAMA Otolaryngol Head Neck Surg 2.951 Surg Oncol 3.304 (prev: Arch Oto …..) JAMA Surg (prev: Arch Surg) 7.956 Surg Oncol Clin N Am 2.281 Int J Cancer 6.513 Surgery 3.904 J Am Coll Surg 4.307 Thyroid 5.515 J Am Soc Nephrol 8.966 Updates In Surgery --- J Bone Miner Metab 2.423 World J Surg 2.673 † Journal names are links to the journal’s homepage!, IF2017: Impact factor 2014, IF 2015, no IF for 2017 ESES Review of Recently Published Literature 2019-2 Page 3 of 71 Thyroid Meta-Analyses Active Surveillance for Small Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis. Thyroid, 29(10):1399-408. S. J. Cho, C. H. Suh, J. H. Baek, S. R. Chung, Y. J. Choi, K. W. Chung, Y. K. Shong and J. H. Lee. 2019. Background: The rapid increase in the incidence of small papillary thyroid carcinoma (PTC) appears to be caused by the detection of small thyroid cancers. Active surveillance (AS) was therefore suggested to overcome this problem. As the results were favorable with low rates of size enlargement and lymph metastasis, the 2015 American Thyroid Association Management Guidelines endorsed AS as an alternative to immediate surgery. As the clinical value of AS is a subject of ongoing active discussions and surveys, we considered a systematic review and meta-analysis to be timely and necessary. Methods: Ovid-MEDLINE and EMBASE databases were searched up to January 5, 2019, for studies reporting patients who were followed up with AS for PTC. Data extraction and methodological quality assessment were performed independently by two radiologists. The primary outcomes were to identify the annual pooled proportions of size enlargement of 3 mm or more and the detection of lymph node metastases at a 5-year follow-up period. These were calculated using an inverse- variance weighting model. An additional outcome was evaluation of the reasons for surgery during AS. Results: The pooled proportion of size enlargement occurring at 5 years was 5.3% [95% confidence interval (CI), 4.4- 6.4%], and the pooled proportion of 5-year lymph node metastasis was 1.6% [CI, 1.1-2.4%]. In many subjects undergoing delayed operations, the reasons for operation were often other than those of size enlargement or lymph node metastasis. Conclusions: AS is effective for the management of small PTC, with a low proportion of size enlargement or lymph node metastasis occurring at 5 years. However, a substantial proportion of the causes of delayed surgery were other than size enlargement or lymph node metastasis, and these situations need to be optimally managed. PubMed-ID: 31368412 http://dx.doi.org/10.1089/thy.2019.0159 Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma? BMC Endocr Disord, 19(Suppl 1):45. C. Gambardella, C. Offi, R. Patrone, G. Clarizia, C. Mauriello, E. Tartaglia, F. Di Capua, S. Di Martino, R. M. Romano, L. Fiore, A. Conzo, G. Conzo and G. Docimo. 2019. BACKGROUND: Medullary thyroid carcinoma is a neuroendocrine tumor belonging form a malignant growth of the thyroid parafollicular C-cells, representing from 1 to 10% of all thyroid cancer. The biochemical activity of medullary thyroid carcinoma includes the production of calcitonin and carcinoembryogenic antigen, which are sensitive tumor markers, facilitating the diagnosis, follow-up and prognostication. The diagnosis is reached through the identification of high basal calcitonin serum level or after pentagastrin stimulation test. Medullary thyroid carcinoma is able to produce other relevant biomarkers as procalcitonin, carcinoembryionic antigen and chromogranin A. In Literature are described few cases of medullary thyroid carcinoma without elevation of serum calcitonin, an extremely rare event. The aim of this study was to analyse the presentation, the main features and therapeutic management of medullary thyroid carcinoma associated with negative serum calcitonin levels. METHODS: Using the PubMed database, a systematic review of the current Literature was carried out, up to February 2018. Finally, nineteen articles met our inclusion criteria and were selected according to the modified Newcastle-Ottawa scale. RESULTS: Fourty-nine patients with definitive pathology confirming medullary thyroid carcinoma and with calcitonin serum level in the normal range were identified (24 female, 24 male and not reported gender in 1 case). Mean age was 51.7 years. Serum calcitonin levels were reported for 20 patients with a mean value of 8.66 pg/mL and a range of 0.8-38 pg/mL. Despite the low or undetectable calcitonin serum level, at immunochemistry in almost the half of the cases reported by the Authors, the tumors presented diffuse or focal positivity for calcitonin and carcinoembryionic antigen, while was reported a chromogranin A positivity in 41 of the 43 tested patients. CONCLUSIONS: Calcitonin negative medullary thyroid carcinoma is an extremely rare pathology. The diagnosis and the surveillance is often challenging and delayed, due to the lack of elevation of serum markers as calcitonin and carcinoembryionic antigen. Further studies are needed, to better define options for management of non secretory medullary thyroid carcinoma and to identify new and reliable biomarkers associated to diagnosis and relapse of this medical dilemma. PubMed-ID: 31142313 http://dx.doi.org/10.1186/s12902-019-0367-2 ESES Review of Recently Published Literature 2019-2 Page 4 of 71 The role of molecular genetics in the clinical management of sporadic medullary thyroid carcinoma: A systematic review. Clin Endocrinol (Oxf), 91(6):697-707. J. M. Fussey, B. Vaidya, D. Kim, J. Clark, S. Ellard and J. A. Smith. 2019. BACKGROUND: The significant variation in the clinical behaviour of sporadic medullary thyroid carcinoma (sMTC) causes uncertainty when planning the management of these patients. Several tumour genetic and epigenetic markers have been described, but their clinical usefulness remains unclear. The aim of this review was to evaluate the evidence for the use of molecular genetic and epigenetic profiles in the risk stratification and management of sMTC. METHODS: MEDLINE and Embase databases were searched using the MeSH terms "medullary carcinoma", "epigenetics", "molecular genetics", "microRNAs"; and free text terms
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