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Management of Advanced and Castration Resistant Prostate Cancer T H E C A N A D I A N J O U R N A L O F ™ CME UROLOGY Accredited INTERNATIONAL SUPPLEMENT Management of Advanced and Castration Resistant Prostate Cancer Editor Leonard G. Gomella, MD Co-Editors Daniel P. Petrylak, MD Indexed in Index Medicus/ Bobby Shayegan, MD MEDLINE and Current Contents/ Clinical Medicine Volume 21 Supplement 1 ISSN 1195-9479 April 2014 Management of Advanced and Castration Resistant Prostate Cancer This continuing medical education activity is jointly provided by the Medical College of Wisconsin, The Canadian Journal of Urology, and CJP Medical Communications, a division of Carden Jennings Publishing Co., Ltd. This supplement has been graciously supported by educational grants from: Astellas Pharma Canada Inc. Bayer HealthCare Pharmaceuticals Janssen Biotech, Inc. Teva Pharmaceuticals THE CANADIAN JOURNAL OF Indexed in Index Medicus/ Volume 21 ™ MEDLINE and Supplement 1 Current Contents/ UROLOGY Clinical Medicine April 2014 Editor-in-Chief Leonard G. Gomella Philadelphia, Pennsylvania Executive Deputy Editor Jack Barkin Toronto, Ontario Associate Editors Timothy D. Averch Bob Djavan Thomas W. Jarrett Pittsburgh, Pennsylvania New York, New York Washington, DC Editorial Board James A. Brown Daniel J. Canter Richard W. Casey Scott Eggener Iowa City, Iowa Philadelphia, Pennsylvania Oakville, Ontario Chicago, Illinois Debra L. Fromer Khurshid A. Guru Fernando J. Kim Carl G. Klutke Hackensack, New Jersey Buffalo, New York Denver, Colorado St. Louis, Missouri Harry P. Koo Seth B. Lerner Kevin R. Loughlin J. Ryan Mark (Resident Liaison) Hackensack, New Jersey Houston, Texas Boston, Massachusetts Philadelphia, Pennsylvania Alireza Moinzadeh James O. Peabody John Phillips Peter A. Pinto Burlington, Massachusetts Detroit, Michigan Valhalla, New York Bethesda, Maryland Ganesh V. Raj Jay D. Raman Grannum R. Sant Bobby Shayegan Dallas, Texas Hershey, Pennsylvania Boston, Massachusetts Hamilton, Ontario Patrick J. Shenot Joel M. H. Teichman J. C. Trussell Gary Weiss Philadelphia, Pennsylvania Vancouver, British Columbia Syracuse, New York New Hyde Park, New York Timothy G. Wilson Stanley Zaslau Kevin C. Zorn Duarte, California Morgantown, West Virginia Montreal, Quebec International Editorial Board Yew-Lam Chong Shin Egawa Peter J. Gilling Hubert John Singapore Tokyo, Japan Tauranga, New Zealand Winterthur, Switzerland Francis Keeley Arturo Mendoza-Valdes Alejandro Nolazco Vincent Ravery Bristol, England Mexico City, Mexico Buenos Aires, Argentina Paris, France Imre Romics Claudio Teloken Ulf W. Tunn Levent Turkeri Budapest, Hungary Porto Alegre, Brazil Offenbach, Germany Istanbul, Turkey Copyright© CJU Communications Inc. - 2014. All rights reserved. TrademarkTM CJU Communications Inc. - 2014. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise) without the prior written permission of the publisher. The Canadian Journal of Urology is published six times a year by CJU Communications Inc., located at 2330 Ward St., Suite 604, St. Laurent, QC, H4M 2V6 Canada. Canadian Publication. ISSN 1195-9479. Publications Mail Agreement Number 40028816. Postage paid at Saint Laurent, Quebec. Statements and opinions expressed herein are solely those of the individual author(s) and do not necessarily reflect those of the publisher or editorial board. The publisher and the members of the editorial board do not endorse any product or service advertised in this publication and disclaim any responsibility or liability for such material. Printed in Canada. Printed on acid-free paper. Visit us at www.canjurol.com. George Georgieff Lena Georgieff David Bushell Advertising Sales: Mtl. Publisher Editorial Coordinator Graphics Tel.: (514) 744-1184 A4 © The Canadian Journal of Urology™: International Supplement, April 2014 CONTINUING MEDICAL EDUCATION INFORMATION Learning Objectives Upon completion of the activity, participants should be able to: 1. Describe the changing landscape of advanced prostate cancer 2. Evaluate the use of imaging technologies in advanced castrate resistant prostate cancer 3. Assess the emerging role of intermittent hormonal therapy in treating castration resistant advanced prostate cancer 4. Define recent developments in prostate cancer treatment that affect and can impact patient quality-of-life outcomes Target Audience The activity is oriented to a targeted audience of physicians and medical care professionals specializing in the diagnosis and treatment of prostate cancer CJP Medical Communications Disclosure The employees of CJP Medical Communications have no financial relationships to disclose. The Canadian Journal of Urology Disclosure The employees of The Canadian Journal of Urology have no financial relationships to disclose. Accreditation Statement This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the Medical College of Wisconsin, The Canadian Journal of Urology and CJP Medical Communications. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians. AMA Credit Designation Statement The Medical College of Wisconsin designates this journal-based CME activity for a maximum of 16.0 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in this activity. Hours of Participation for Allied Health Care Professionals The Medical College of Wisconsin designates this activity for up to 16.0 hours of participation for allied health professionals. Off-Label/Investigational Use This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the United State Food and Drug Administration. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the Medical College of Wisconsin, The Canadian Journal of Urology, Carden Jennings Publishing, or the sponsors. Before prescribing any medication, physicians should consult primary references and full prescribing information. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program. Release Date: April 7, 2014 Expiration Date: April 1, 2015 Time to Complete Activity: 16.0 hours © The Canadian Journal of Urology™: International Supplement, April 2014 A5 CONTRIBUTORS Editor Leonard G. Gomella, MD The Bernard W. Godwin Professor of Prostate Cancer Chairman, Department of Urology Clinical Director Jefferson Kimmel Cancer Center Network Thomas Jefferson University Philadelphia, PA USA Co-Editors Daniel P. Petrylak, MD Bobby Shayegan, MD Professor, Medical Oncology Associate Professor, Urologic Oncology Director, Prostate and Genitourinary Cancers Deputy Chief of Surgery SJHH Yale Cancer Center McMaster University New Haven, CT USA Hamilton, ON Canada Primary Authors E. David Crawford, MD Judd W. Moul, MD Professor of Surgery and Radiation Oncology Director, Duke Prostate Center Head of Section on Urologic Oncology Division of Urologic Surgery University of Colorado Health Sciences Center Duke University Medical Center Denver, CO USA Durham, NC USA Robert B. Den, MD Ganesh Raj, MD Radiation Oncologist Assistant Professor Kimmel Cancer Center Oncology Fellowship Director Thomas Jefferson University UT Southwestern Medical Center Philadelphia, PA USA Dallas, TX USA Robert Dreicer, MD Lawrence Schwartz, MD Professor, Cleveland Clinic Chairman Professor and Chairman Department of Solid Tumor Oncology Department of Radiology Taussig Cancer Institute Columbia University Medical Center Cleveland, OH USA New York, NY USA Christopher Evans, MD, Bertrand Tombal, MD Professor and Chairman, Department of Urology Chairman Urologic Surgical Oncology Division of Urology University of California, Davis, Medical Center Cliniques Universitaires Saint-Luc Sacramento, CA USA Brussels, Belgium W. Kevin Kelly, DO Eric Winquist, MD Professor, Medical Oncology and Urology Professor, Department of Oncology Director of the Solid Tumor Oncology Medical Director, Clinical Cancer Research Program Kimmel Cancer Center, Thomas Jefferson University London Health Sciences Centre Philadelphia, PA USA London, ON Canada Daniel W. Lin, MD Professor, Department of Urology Chief of Urologic Oncology University of Washington Seattle, WA USA A6 © The Canadian Journal of Urology™: International Supplement, April 2014 CONTRIBUTORS Co-Authors Christopher Brian Allard, MD Karen E. Knudsen, MD Division of Urology Department of Urology McMaster University Thomas Jefferson University Hamilton, ON Canada Philadelphia, PA USA Sohaib Al-Asaaed, MD Saravanan Krishnamoorthy, MD London Health Sciences Centre Department of Radiology Western University Columbia University Medical Center London, ON Canada New York, NY USA Valentina Butoescu, MD Chandan Kundavram, MD Department of Urology Department of Urology Cliniques Universitaires Saint-Luc Thomas Jefferson University Brussels, Belgium Philadelphia, PA USA Paul H. Chung, MD David Leung, MD Department of Urology Department of Radiology University of Texas Southwestern Medical Center Columbia
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