2020 AAAS Fellows Fellowship Rosette
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Autophagic Pathways in Health and Disease: Mitophagy and Neurodegeneration Nektarios Tavernarakis Institute of Molecular Biology
Autophagic pathways in health and disease: Mitophagy and neurodegeneration Nektarios Tavernarakis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Medical School, University of Crete, Heraklion, Crete, Greece Mitochondria, the main energy hub of the cell, are highly dynamic organelles, playing essential roles in fundamental cellular processes. Mitochondrial function impinges on several signalling pathways modulating cellular metabolism, cell survival and healthspan. Maintenance of mitochondrial function and energy homeostasis requires both generation of newly synthesized and elimination of dysfunctional mitochondria. Impaired mitochondrial function and excessive mitochondrial content are major characteristics of ageing and several human pathophysiological conditions, highlighting the pivotal role of the coordination between mitochondrial biogenesis and mitophagy. However, the cellular and molecular underpinnings of mitochondrial mass homeostasis remain obscure. We found that DCT-1, the Caenorhabditis elegans homolog of mammalian BNIP3 and BNIP3L/NIX, is a key mediator of mitophagy promoting longevity under stress. DCT-1 acts downstream of the PINK-1-PDR-1/Parkin pathway and is ubiquitinated upon mitophagy-inducing conditions to mediate the removal of damaged mitochondria. Accumulation of damaged mitochondria triggers SKN-1 activation, which initiates a bipartite retrograde signaling pathway stimulating the coordinated induction of both mitochondrial biogenesis and mitophagy genes. Taken together, our results unravel a homeostatic feedback loop that allows cells to adjust their mitochondrial population in response to environmental and intracellular cues. Age-dependent decline of mitophagy both inhibits removal of dysfunctional or superfluous mitochondria and impairs mitochondrial biogenesis resulting in progressive mitochondrial accretion and consequently, deterioration of cell function. . -
Bernd Schoner, Ph.D
Bernd Schoner, Ph.D. 108 Auburn St. 1 Washington Sq. Vil. Cambridge, MA 02139 New York , NY 10012 berndschoner [at] gmail [dot] com _____________________________________________________________________________________________ EMPLOYMENT THINGMAGIC, A DIVISION OF TRIMBLE NAVIGATION LIMITED 2010 – present Cambridge, Massachusetts. VP Business Development. Leading integration of ThingMagic product within Trimble vertical divisions in engineering, construction, and mobile computing. Managing ThingMagic’s largest OEM accounts. Selling high-Profile technology projects in heavy-civil and vertical construction. THINGMAGIC, INC. 2005 – 2010 Cambridge, Massachusetts. Co-Founder and President. Led corPorate conversion to C-Corporation. Hired senior executives and middle management to scale the comPany to 60 PeoPle. Managed a team of 40 in charge of all technical oPerations, development and manufacturing. Led intellectual property strategy including the establishment of the RFID patent pool and defensive licensing arrangements. Transitioned into business development managing key accounts and worldwide sales. Travelled to more than fifty countries to build an international distribution channel for ThingMagic’s Products. THINGMAGIC, LLC 2000 – 2005 Cambridge, Massachusetts. Co-Founder and Managing Partner. Set-up corporate structure, legal representation, accounting. Led project and customers acquisition. Negotiated high-profile technology licensing deals. Hired executive advisor and CEO. Led transformation from services to product and manufacturing-based -
Quantum Computing with Molecules
Reproduced with permission. Copyright (c) 1998 by Scientific American, Inc. All rights reserved. Quantum Computing with Molecules By taking advantage of nuclear magnetic resonance, scientists can coax the molecules in some ordinary liquids to serve as an extraordinary type of computer by Neil Gershenfeld and Isaac L. Chuang ........... SUBTOPICS: Action at a Distance Spin Doctoring Two Things at Once ILLUSTRATIONS: Desktop Quantum Computer Factoring a number with 400 digits--a numerical feat needed to break some security codes--would take even the fastest supercomputer in existence billions of Magnetic Nucleus years. But a newly conceived type of computer, one that exploits quantum- Controlled-NOT mechanical interactions, might complete the task in a year or so, thereby defeating Logic Gate many of the most sophisticated encryption schemes in use. Sensitive data are safe Cracking A for the time being, because no one has been able to build a practical quantum Combination computer. But researchers have now demonstrated the feasibility of this approach. Such a computer would look nothing like the machine that sits on your desk; surprisingly, it might resemble the cup of coffee at its side. FURTHER READING We and several other research groups believe quantum computers based on the molecules in a liquid might one day overcome many of the limits facing RELATED LINKS conventional computers. Roadblocks to improving conventional computers will ultimately arise from the fundamental physical bounds to miniaturization (for example, because transistors and electrical wiring cannot be made slimmer than the width of an atom). Or they may come about for practical reasons--most likely because the facilities for fabricating still more powerful microchips will become prohibitively expensive. -
Making Governance Work Is a Series of Essays from University, Business
Making Governance Work is a series of essays from university, business and political leaders about proper leadership for the University of North Carolina System – the principles, structure, roles and restraint required for efficient operation of our public universities. A discussion of UNC System governance ..................................................... 3 By Paul Fulton History of UNC governance: ‘Lot of cooks in the kitchen’ .................... 5 By D.G. Martin Principles for governance reform ...................................................................... 7 By Holden Thorp and Buck Goldstein Strengthening the UNC System for future generations ......................10 By Richard Burr and Erskine Bowles Building a perfect Board of Governors .........................................................12 By Lou Bissette Give our universities room to work ..................................................................14 By Hugh McColl Put the skunk on the table ...................................................................................16 By E. Gordon Gee Belle Wheelan: Stay in your lane .....................................................................18 Accountability, not activism ................................................................................19 By Don Flow BOG Governance Committee takes up… governance ...........................21 By David Rice, Higher Ed Works Stable leadership to move NC forward ........................................................23 By Dale Jenkins and Andrea Smith Organizing -
2010 Final Report Ncsciencefestival.Org 3 the Nation’S First Statewide >> Event Map & Highlights Science Festival
the nation’s first statewide science festival proudly produced by final 2010report the nation’s first statewide >> letter to our supporters >> festival highlights science festival December 2010 Dear friends, 85,860 16 The authors James Collins and Jerry Porras introduced the concept of the strategic, emotionally-compelling Big Hairy Audacious total attendance at NC days in first NC Science Goal (“BHAG”), defining a true BHAG as a goal that is “clear and compelling, serves as a unifying focal point, and acts as a Science Festival events Festival (Sept. 11–26, 2010) clear catalyst for team spirit.” The idea of creating the nation’s first statewide science festival was truly a BHAG when the idea started to take shape in late 2009. But from Orville and Wilbur’s first flight to our basketball teams, North Carolina takes pride in being first. And as we introduced the idea of the North Carolina Science Festival, North Carolina responded enthusiastically. From elementary school students to transnational corporations, we found partners and supporters around every corner and an 413 174 appetite for science that heartened us. individual events unique events First, our state’s business community immediately saw (including repeat sessions) the Festival’s value and provided sponsorship dollars that helped us deliver a high-quality program of events. Without our sponsors, we would not have been able to present the Festival. All of our sponsors are very important to us, but 78 111 we think that the Burroughs Wellcome Fund, SAS and Time unique events Warner Cable & News 14 Carolina deserve special recognition program partners for having the faith in our vision to become Platinum Sponsors in the Piedmont in the very first year. -
Facilities Inventory and Utilization Study 2010
STATE OF NORTH CAROLINA HIGHER EDUCATION COMPREHENSIVE PLANNING PROGRAM FACILITIES INVENTORY AND UTILIZATION STUDY 2010 School of Pharmacy, Elizabeth City State University HIGHER EDUCATION COMPREHENSIVE PLANNING PROGRAM FACILITIES INVENTORY AND UTILIZATION STUDY FALL OF 2010 For THE STATE OF NORTH CAROLINA FORTY-FOURTH EDITION THE UNIVERSITY OF NORTH CAROLINA Facilities Space Utilization and Analysis Chapel Hill, North Carolina September 2011 School of Pharmacy Complex Elizabeth City State University (Cover Page) Starting in fall 2010, pharmacy students at the Elizabeth City site began taking their classes in a new 52,500 square foot building located at the west entrance to the ECSU campus. This $21.9 million, three story facility, whose architecture was inspired by the idea of an apothecary chest, overlooks an artificial pond and contains classrooms and labs organized around a two-story atrium. The first floor contains general science labs, a library, and a drug information center, while the second floor houses the IV simulation lab and the compounding lab. The third floor features three research labs for biochemistry, molecular biology, and medicinal chemistry, as well as a computer lab. Other classrooms, meeting rooms, and offices are distributed throughout the building to create a more collaborative environment for students, faculty, and staff. In the last decade, 45 of North Carolina’s 100 counties did not increase their supply of pharmacists rapidly enough to keep pace with population growth. Due to a need for more pharmacists in eastern North Carolina, the General Assembly allocated funds in 2004 for a new pharmacy program at Elizabeth City State University to be taught in conjunction with faculty located at the University of North Carolina at Chapel Hill. -
203046 Omslag
SUSTAINABILITY AT THE SPEED OF AT LIGHT SUSTAINABILITY Over the last few years, information technology’s This report is a contribution from WWF to the impact on society has become a hot topic. It is clear discussion about ICT in tomorrow’s society. We have that over the next couple of years information and asked some of the best experts in the world to cont- communication technologies (ICT) will affect and ribute with a chapter in which they describe the role reshape most parts of our society. ICT will come to of ICT for Sustainable Development in their respec- radically influence the global economy, and, to an tive fields. The report is an attempt to bridge the gap unknown degree, our culture and the way we percei- between the ICT experts and the policy makers in ve the world, our relationship to it, and our actions. politics and business. It is WWFs firm belief that Although ICT will have an enormous effect these groups, together with the rest of society, need on tomorrow’s society, surprisingly little research to talk more frequently and openly to each other if has been conducted regarding its future environ- we want to create a sustainable framework for the arlstad, Sweden mental consequences. Most of the work that has ICT-development. been done has reached one of two opposing con- clusions: either ICT will bring only good things, from solutions to world hunger and the elimination of all transportation problems to a revitalised democra- cy; or it will bring nothing but problems, accelera- ting resource consumption, introducing new toxic materials and resulting in greater inequity by intro- ducing a digital divide that will worsen the already unequal distribution of wealth and influence. -
Advisory Committee for GPRA Performance Nsf05210
July 26, 2005 The Honorable Arden L. Bement, Jr. Director National Science Foundation 4201 Wilson Boulevard Arlington, VA 22230 Dear Dr. Bement: We are pleased to submit the report of the Advisory Committee for GPRA Performance Assessment (AC/GPA) for 2005. It was the unanimous judgment of the Committee that NSF has demonstrated significant achievement for all indicators in the Ideas and Tools goals and also for the merit review indicator of the Organizational Excellence outcome goal. The Committee concluded that NSF demonstrated significant achievement for indicators P1-P4 of the People goal, but has not done so with respect to P5. The Advisory Committee on Business and Operations concluded that NSF demonstrated significant achievement for the other indicators of the Organizational Excellence goal. The Committee also concluded that the four outcome goals are mutually reinforcing and synergistic. They represent an integrated framework that combines research and education in a positive way and also provides the organizational infrastructure to advance the national scientific, technological, engineering, and mathematics enterprise. Thus, all four goals should always be considered as an integrated whole when assessing NSF’s performance. The Committee appreciates the continued improvement in the AC/GPA process this year. Not only were we again able to do much of our work in advance of the meeting, but NSF also provided periodic updates on the progress of each subgroup in its analyses of indicators. This Committee, with NSF’s invaluable assistance, has, we believe, modeled the very organizational excellence behavior that we seek from NSF. We also note that this committee is, perhaps, unique within the Federal government. -
Programming Bits and Atoms Neil Gershenfeld MIT Center for Bits and Atoms
Programming Bits and Atoms Neil Gershenfeld MIT Center for Bits and Atoms Thursday, April 24, 2014 at 1:30pm RTH 526 Software is digital, but not physical: it is represented by bits of information that are written without physical units. Hardware is physical, but not digital: it can contain information, but its own construction is continuous. I will present research on aligning the descriptions of software and hardware, and explore its implications for the future of computation and fabrication. Prof. Neil Gershenfeld is the Director of MIT's Center for Bits and Atoms. His unique laboratory is breaking down boundaries between the digital and physical worlds, from creating molecular quantum computers to virtuosic musical instruments. Technology from his lab has been seen and used in settings including New York's Museum of Modern Art and rural Indian villages, the White House and the World Economic Forum, inner-city community centers and automobile safety systems, Las Vegas shows and Sami herds. He is the author of numerous technical publications, patents, and books including Fab, When Things Start To Think, The Nature of Mathematical Modeling, and The Physics of Information Technology, and has been featured in media such as The New York Times, The Economist, NPR, CNN, and PBS. He is a Fellow of the American Physical Society, has been named one of Scientific American's 50 leaders in science and technology, as one of 40 Modern-Day Leonardos by the Museum of Science and Industry, one of Popular Mechanic's 25 Makers, has been selected as a CNN/Time/Fortune Principal Voice, and by Prospect/Foreign Policy as one of the top 100 public intellectuals. -
Nucleophagy: from Homeostasis to Disease
Cell Death & Differentiation (2019) 26:630–639 https://doi.org/10.1038/s41418-018-0266-5 REVIEW ARTICLE Nucleophagy: from homeostasis to disease 1,2 1,2 Margarita-Elena Papandreou ● Nektarios Tavernarakis Received: 7 November 2018 / Revised: 9 December 2018 / Accepted: 17 December 2018 / Published online: 15 January 2019 © The Author(s) 2019. This article is published with open access Abstract Nuclear abnormalities are prominent in degenerative disease and progeria syndromes. Selective autophagy of organelles is instrumental in maintaining cell homeostasis and prevention of premature ageing. Although the nucleus is the control centre of the cell by safeguarding our genetic material and controlling gene expression, little is known in relation to nuclear autophagy. Here we present recent discoveries in nuclear recycling, namely nucleophagy in physiology in yeast and nucleophagic events that occur in pathological conditions in mammals. The selective nature of degrading nuclear envelope components, DNA, RNA and nucleoli is highlighted. Potential effects of perturbed nucleophagy in senescence and longevity are examined. Moreover, the open questions that remain to be explored are discussed concerning the conditions, receptors and substrates in homeostatic nucleophagy. 1234567890();,: 1234567890();,: Facts: ● Are there different types of macronucleophagy depend- ing on the underlying triggering conditions and different ● Selective autophagy of nuclear components is termed mechanisms that would selectively degrade different nucleophagy nuclear -
Protein Metabolism and Homeostasis in Aging Series: Advances in Experimental Medicine and Biology
springer.com Nektarios Tavernarakis (Ed.) Protein Metabolism and Homeostasis in Aging Series: Advances in Experimental Medicine and Biology Illustrates that aging cells are characterized by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation is controlled at multiple levels Discusses paradoxical situation of autophagy up-regulation in models of premature aging Role of mitochondria in protein quality control and the influence of reactive oxygen species Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal 2010, XXI, 249 p. maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is Printed book provided of the current knowledge in the area, including protein synthesis, accuracy and repair, Hardcover post-translational modifications, degradation and turnover, and how they define and influence 199,99 € | £179.99 | $249.99 aging. The chapters mainly focus on well-characterised factors and pathways, but new areas [1]213,99 € (D) | 219,99 € (A) | CHF are also presented, where associations with aging are just being elucidated by current 236,00 experimental data. Protein turnover, the balance between protein synthesis and protein Softcover degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging 186,90 € | £139.99 | $219.99 cells are characterised by alterations in the rate, level and accuracy of protein synthesis [1]199,98 € (D) | 205,59 € (A) | CHF compared to young ones, and that mRNA translation, essential for cell growth and survival, is 220,50 controlled at multiple levels. -
Assessment of De Novo Protein Synthesis Rates in Caenorhabditis Elegans
Materials List for Assessment of de novo Protein Synthesis Rates in Caenorhabditis elegans Margarita Elena Papandreou*1,2, Konstantinos Palikaras*1,2, Nektarios Tavernarakis1,2 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece * These authors contributed equally Corresponding Author Citation Nektarios Tavernarakis Papandreou, M.E., Palikaras, K., Tavernarakis, N. Assessment of de novo Protein [email protected] Synthesis Rates in Caenorhabditis elegans. J. Vis. Exp. (), e61170, doi:10.3791/61170 (2020). Date Published DOI URL September 12, 2020 10.3791/61170 jove.com/video/61170 Materials Name Company Catalog Number Comments Agar Sigma-Aldrich 5040 Agarose Biozym 8,40,004 Agarose pads 2% Calcium chloride dehydrate (CaCl2? Sigma-Aldrich C5080 2H2O) Cholesterol SERVA Electrophoresis 17101.01 cycloheximide Sigma-Aldrich C-7698 Dissecting stereomicroscope Nikon Corporation SMZ645 edc-3(ok1427);Ex[punc-119GFP, Tavernarakis lab Maintain animals at 20 °C pRF4] Epifluorescence microscope Zeiss Axio Imager Z2 Escherichia coli OP50 strain Caenorhabditis Genetics Center (CGC) Fluorescence dissecting Zeiss SteREO Lumar V12 stereomicroscope Greiner Petri dishes (60 x 15 mm) Sigma-Aldrich P5237 ife-2(ok306);Ex[pife-2GFP, pRF4] Tavernarakis lab Maintain animals at 20 °C image analysis software Fiji https://fiji.sc KH2PO4 EMD Millipore 1,37,010 K2HPO4 EMD Millipore 1,04,873 LB liquid medium