H. Holden Thorp Dean, College of Arts and Sciences Kenan Professor of Chemistry Chancellor-Elect Address

H. Holden Thorp Dean, College of Arts and Sciences Kenan Professor of Chemistry Chancellor-Elect

Address: College of Arts and Sciences University of North Carolina Chapel Hill, NC 27599-3100 (919)962-3082

Academic Positions: Department of Chemistry, North Carolina State University: Assistant Professor (January 1991 - June 1993). Department of Chemistry, University of North Carolina at Chapel Hill: Visiting Assistant Professor (January - June 1993), Assistant Professor (July 1993 - December 1995), Associate Professor (January 1996 – June 1999), Vice-Chair for Undergraduate Studies (July 1995 – June 2000), Member of the Lineberger Comprehensive Cancer Center (January 1997 - present), Professor (July 1999 – June 2005); Kenan Professor (July 2005 – present); Department Chair (July 2005 – May 2007); Faculty Director of Fundraising, Carolina Physical Science Complex (2003 – 2007). Morehead Planetarium and Science Center, University of North Carolina at Chapel Hill: Director (August 2001 – June 2005). College of Arts and Sciences, University of North Carolina at Chapel Hill: Dean (July 2007 – June 2008). Chancellor, University of North Carolina at Chapel Hill: (beginning July 2008)

Education: Post-doctoral: Yale University (July 1989 - December 1990) Advisor: Gary W. Brudvig

Graduate: California Institute of Technology (1986 - 1989) Ph.D. Chemistry - June 1989 Graduate research advisor: Harry B. Gray

Undergraduate: University of North Carolina - Chapel Hill (1982 - 1986) B.S. Chemistry - May 1986 Undergraduate research advisor: Thomas J. Meyer

Fellowships and Honors: London Scientific Lecturer (Simon Fraser University – 2006), Kenan Professorship (2004), UNC General Alumni Association Distinguished Young Alumnus (2002), Honorary Member of the Order of the Golden Fleece (2002), Fortune Small Business Top Innovators of 2001, CED Life Science Technology of the Year (2000), NAS Frontiers of Science Participant (1999), Tanner Award for Excellence in Undergraduate Teaching (1998), Ruth and Philip Hettleman Prize for Artistic and Scholarly Achievement (1996), Alfred P. Sloan Fellowship (1996), Camille Dreyfus Teacher-Scholar (1995), David and Lucile Packard Fellowship for Science and Engineering (1991), NSF Presidential Young Investigator (1991), Camille and Henry 2

Dreyfus New Faculty Award (1990), National Science Foundation Graduate Fellowship (1987).

Professional Activities: Co-Editor, Bioinorganic Chemistry issue, Current Opinion in Chemical Biology (2005); Sigma Xi Committee on Science in the Public Interest (2004 – 2007); Board of Directors, North Carolina Center for Science, Math, and Technology Education (2002 – 2007); NIH Metallobiochemistry Study Section (February 1999, October 1999); NIH Special Emphasis Panel on SBIR and STTR Grants (November 2001, March 2003); NASA Advanced Monitoring and Control Peer Review Panel (July 2000).

Industry activities: Co-Founder and Scientific Advisory Board, Viamet Pharmaceuticals (2005 – present); Scientific Advisory Board, OhmX, Inc. (2005 – present); Technical Advisory Board, Plextronics, Inc. (2007 – present); Consultant, Firelake Capital (2005 – present); Consultant, Osmetech, Inc. (2005 – present); Venture Partner, Hatteras Venture Partners (2007 – present); Consultant, Clinical Micro Sensors, A Motorola Company (2003 – 2005); Scientific Advisory Board, MaxCyte, Inc. (2004 – 2006); Chair of Scientific Advisory Board, Director, and Founder, Xanthon, Inc. (1996 – 2002); President, Xanthon, Inc. (2002 – 2005); Scientific Advisory Board, Novalon Pharmaceutical Corporation, (1996 – 1999); Consultant, NeXstar Pharmaceuticals (1995); Consultant, Burroughs-Wellcome Co. (1993 – 1996).

Selected public talks: UNC December Commencement (2006); Cum Laude Address, Episcopal High School (2007); Carolina United Keynote Address (2007); Carolina Challenge Celebration (2007); Carolina Union Last Lecture (1999), Carolina Scholars Banquet (2001), NC District 7 Leadership Summit (2003, 2005), Governor’s School West (2003), “Happy Birthday DNA,” Annual Meeting of the Association of Science and Technology Centers (2003); Dupont Appreciation Day, Methodist College (2003); Panel on the Future of the University, 100th Anniversary of the Order of the Golden Fleece (2004); Phi Beta Kappa Induction, UNC-Greensboro (2004).

Publications: 1. Electrocatalytic Carbon Dioxide Reduction. B. P. Sullivan, M. R. M. Bruce, T. R. O'Toole, C. M. Bolinger, E. Megehee, H. Thorp, T. J. Meyer ACS Symp. Ser. 1988, 363, 52. 2. Electrocatalytic Reduction of CO2 by Associative Addition. M. R. M. Bruce, E. Megehee, B. P. Sullivan, H. Thorp, T. R. O'Toole, A. Downard, T. J. Meyer Organometallics 1988, 7, 238. 3. Excited-State Properties of Dioxorhenium(V). Generation and Reactivity of Dioxorhenium(VI). H. H. Thorp, J. Van Houten, H. B. Gray Inorg. Chem. 1989, 28, 889. 4. Emission Properties of Dioxorhenium(V) Complexes in Aqueous Solutions of Anionic and Nonionic Surfactants: A Sensitive Probe of Hydrophobic Binding Regions. H. H. Thorp, C. V. Kumar, N. J. Turro, H. B. Gray J. Am. Chem. Soc. 1989, 111, 4364. 3+ 5. Proton-Coupled Electron Transfer in [(bpy)2Mn(O)2Mn(bpy)2] . H. H. Thorp,* J. E. Sarneski, G. W. Brudvig, R. H. Crabtree J. Am. Chem. Soc. 1989, 111, 9249. 3

3+ 6. Proton-Coupled Electron Transfer in [(bpy)2Mn(O)2Mn(bpy)2] . Role of the Electrode Surface. H. H. Thorp,* E. F. Bowden, G. W. Brudvig J. Electroanal. Chem. 1990, 290, 293. 7. Assembly of High-Valent Oxomanganese Clusters in Aqueous Solution. Redox 4+ 3+ Equilibrium of Water-Stable Mn3O4 and Mn2O2 Complexes. J. E. Sarneski, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree, G. K. Schulte J. Am. Chem. Soc. 1990, 112, 7255. 8. The Physical Inorganic Chemistry of Manganese Relevant to Photosynthetic Oxygen Evolution. H. H. Thorp, G. W. Brudvig New J. Chem. 1991, 15, 479. 9. Proton-Coupled Electron Transfer in Oxomanganese Dimers: Role of the Ancillary Ligands. R. Manchanda, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree Inorg. Chem. 1991, 30, 494. 10. Physical Properties of a Manganese Tetramer with All-Oxygen Coordination. H. H. Thorp, J. E. Sarneski, R. J. Kulawiec, G. W. Brudvig, R. H. Crabtree, G. C. Papaefthymiou Inorg. Chem. 1991, 30, 1153. 11. The Photochemistry of Dioxorhenium(V) Complexes in DNA: Multiple Binding Regions and Oxidative Cleavage. H. H. Thorp, N. J. Turro, H. B. Gray New J. Chem. 1991, 15, 601 - 604. 12. Electronic Structure of trans-Dioxorhenium(VI). J. C. Brewer, H. H. Thorp, K. M. Slagle, G. W. Brudvig, H. B. Gray J. Am. Chem. Soc. 1991, 113, 3171. 13. Alkyl Hydroperoxide Oxidation of Alkanes and Alkenes with a Highly Active Mn Catalyst. J. E. Sarneski, D. Michos, H. H. Thorp, M. Didiuk, T. Poon, G. W. Brudvig, R. H. Crabtree Tet. Lett. 1991, 32, 1153. 14. Photophysics of Dioxorhenium(V) in Nafion. H. H. Thorp, H. B. Gray Photochem. Photobiol. 1991, 54, 609. 15. A High-Valent Oxomanganese Cluster Containing Inorganic Phosphate. J. E. Sarneski, M. Didiuk, H. H. Thorp, G. W. Brudvig, R. H. Crabtree, J. W. Faller, G. K. Schulte Inorg. Chem. 1991, 30, 2833. 16. Efficient Electrocatalytic and Stoichiometric Cleavage of DNA by Oxoruthenium(IV). N. Grover, H. H. Thorp J. Am. Chem. Soc. 1991, 113, 7030 - 7031. 17. Temperature-Dependent Cyclic Voltammetry of Oxo-Bridged Dimers of Relevance to Photosynthetic Water Oxidation. W. A. Kalsbeck, H. H. Thorp,* G. W. Brudvig J. Electroanal. Chem. 1991, 314, 335 - 343. 4- 18. Photolytic Cleavage of DNA by Pt2(pop)4 . W. A. Kalsbeck, N. Grover, H. H. Thorp Angew. Chem. Int. Ed. Engl. 1991, 30, 1517 - 1518. 19. Electrochemical Reduction of Fullerenes in the Presence of O2 and H2O: Polyoxygen Adducts and Fragmentation of the C60 Framework. W. A. Kalsbeck, H. H. Thorp J. Electroanal. Chem. 1991, 314, 363 - 370. 20. Electrochemistry of Proton-Coupled Redox Reactions: Role of the Electrode Surface. H. H. Thorp J. Chem. Educ. 1992, 69, 250 - 252. 21. Proton-Coupled Electron Transfer in Metal Complexes: Applications in Catalysis, Molecular Electronics, and Biochemistry (Feature Article). H. H. Thorp Chemtracts: Inorganic Chemistry, 1991, 3, 171 - 184. 22. Probing the Mechanism of Water Oxidation by Photosystem II. G. W. Brudvig,* H. H. Thorp, R. H. Crabtree Acc. Chem. Res., 1991, 24, 311 - 316. 4

23. Studies of Electrocatalytic DNA Cleavage by Oxoruthenium(IV). X-Ray Crystal Structure of [Ru(tpy)(tmen)OH2](ClO4)2 (tmen = N,N,N',N'- tetramethylethylenediamine, tpy = 2,2',2''-terpyridine). N. Grover, N. Gupta, P. Singh, H. H. Thorp Inorg. Chem. 1992, 31, 2014 - 2020. 24. Binding of Alkali Cations by Self-Assembling Ionophore Complexes of Ni(II). M. W. Jones, N. Gupta, A. Schepartz, H. H. Thorp Inorg. Chem. 1992, 31, 1308 - 1310. 25. Stereoselective Covalent Binding of Aquaruthenium(II) Complexes to DNA. N. Grover, N. Gupta, H. H. Thorp J. Am. Chem. Soc. 1992, 114, 3390 - 3393. 26. Bond Valence Sum Analysis of Metal-Ligand Bond Lengths in Metalloenzymes and Model Complexes. H. H. Thorp Inorg. Chem. 1992, 31, 1585 - 1588. 27. Toward a Functional Model of Hydrogenase: Electrocatalytic Reduction of Protons by a Ni Macrocyclic Complex. L. L. Efros, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree Inorg. Chem. 1992, 31, 1722 - 1724. 28. Ru(tpy)(dppz)O2+: A High-Affinity DNA Cleavage Reagent. N. Gupta, N. Grover, G. A. Neyhart, W. Liang, P. Singh, H. H. Thorp Angew. Chem. Int. Ed. Engl. 1992, 31, 1048 - 1050. 29. An Unusual Example of Multiple Proton-Coupled Electron Transfers in a High- III IV Valent Oxomanganese Dimer, [(phen)2Mn (O)2Mn (phen)2](ClO4)3 (phen = 1,10-phenanthroline). R. Manchanda, H. H. Thorp, G. W. Brudvig,* R. H. Crabtree Inorg. Chem. 1992, 31, 4040 - 4041. 30. Excited-State Proton Transfer in Transdioxorhenium(V). W. Liu, T. W. Welch, H. H. Thorp Inorg. Chem. 1992, 31, 4044 - 4045. 31. New Mechanisms in DNA Cleavage by Metal Complexes. H. H. Thorp J. Inorg. Organomet. Polymers 1993, 3, 111 - 157. 32. Synthesis and Properties of New DNA Cleavage Agents Based on Oxoruthenium(IV). N. Gupta, N. Grover, G. A. Neyhart, P. Singh, and H. H. Thorp Inorg. Chem. 1993, 32, 310 - 316. 33. Electrocatalytic Reduction of Carbon Dioxide Based on 2,2'-Bipyridyl Complexes of Osmium. M. R. M. Bruce, E. Megehee, B. P. Sullivan,* H. H. Thorp, T. R. O'Toole, A. Downard, R. R. Pugh, T. J. Meyer* Inorg. Chem. 1992, 31, 4864 - 4873. 34. Binding and Kinetics Studies of DNA Oxidation by Oxoruthenium(IV). G. A. Neyhart, N. Grover, S. R. Smith, W. A. Kalsbeck, T. A. Fairley, M. Cory, H. H. Thorp J. Am. Chem. Soc. 1993, 115, 4423 - 4428. 35. Electronic Structures of Tungsten-Chalcogen Multiple Bonds. J. A. Paradis, D. W. Wertz, H. H. Thorp J. Am. Chem. Soc. 1993, 115, 5308-5309. 36. Determining Binding Constants of Metal Complexes to DNA by Quenching of the 4- 4- Emission of Pt2(pop)4 (pop = P2O5H2 ). W. A. Kalsbeck, H. H. Thorp J. Am. Chem. Soc. 1993, 115, 7146 - 7151. 37. Electronic Properties of Aquapolpyrydyl Ruthenium Complexes Bound to DNA. S. R. Smith, G. A. Neyhart, W. A. Kalsbeck, H. H. Thorp New J. Chem. 1994, 18, 397-406. 38. Bond Valence Sum Analysis of Metal-Ligand Bond Lengths in Metalloenzymes and Model Complexes. 2. Refined Distances and Other Enzymes. W. Liu, H. H. Thorp Inorg. Chem. 1993, 32, 4102 - 4105. 5

39. Excited-State Quenching Through Large Intrinsic Barriers: Proton-Transfer Reactions of Metal Hydrides. J. G. Goll, W. Liu, H. H. Thorp J. Am. Chem. Soc. 1993, 115, 11048 - 11049. 40. Thymine-Specific Cleavage of DNA by Octahedral Oxopolypyridylruthenium(IV) Complexes. T. W. Welch, G. A. Neyhart, S. A. Ciftan, J. G. Goll, H. H. Thorp J. Am. Chem. Soc. 1993, 115, 9311 - 9312. 41. Mechanisms of DNA Cleavage by High-Valent Metal Complexes. G. A. Neyhart, W. A. Kalsbeck, T. W. Welch, N. Grover, H. H. Thorp, Adv. Chem. Ser. 1995, 246, 405 - 430. 42. Effect of Ancillary Ligands on the Proton-Transfer Reactivity of the Excited State of Transdioxorhenium(V). W. Liu, H. H. Thorp Inorg. Chem. 1994, 33, 1026 - 1031. 43. Understanding the Mechanisms of Bioinorganic Chemistry. H. H. Thorp Adv. Chem. Ser. 1995, 246, 1 - 20. 44. Role of the Buffer Cation in Determining Binding Constants of Metal Complexes to DNA. W. A. Kalsbeck, H. H. Thorp Inorg. Chem. 1994, 33, 3427 - 3429. 4- 45. Understanding the Interactions of Pt2(pop)4 with DNA: Photocatalytic Hydrogen 2- Abstraction in Aqueous Solution (pop = P2O5H2 ). W. A. Kalsbeck, D. M. Gingell, J. E. Malinsky, H. H. Thorp Inorg. Chem. 1994, 33, 3313 - 3316. 46. Covalent Binding of Aquapolpyridyl Ruthenium Complexes to DNA. N. Grover, T. W. Welch, T. A. Fairley, M. Cory, H. H. Thorp Inorg. Chem. 1994, 33, 3544 - 3548. 47. Transdioxorhenium(V)-Mediated Electrocatalytic Oxidation of DNA at Indium Tin- Oxide Electrodes: Voltammetric Detection of DNA Cleavage in Solution. D. H. Johnston, C.-C. Cheng, K. J. Campbell, H. H. Thorp Inorg. Chem. 1994, 33, 6388 - 6390. 48. Relative Rates and Potentials of Competing Redox Processes During DNA Cleavage: Oxidation Mechanisms and Sequence-Specific Catalysis of the Self-Inactivation of Oxometal Oxidants by DNA. C.-C. Cheng, J. G. Goll, G. A. Neyhart, T. W. Welch, P. Singh, H. H. Thorp J. Am. Chem. Soc. 1995, 117, 2970 - 2980. 49. Kinetics and Mechanism of the Oxidation of Sugars and Nucleotides by Oxoruthenium(IV): Model Studies for Predicting Cleavage Patterns in DNA and RNA. G. A. Neyhart, C.-C. Cheng, H. H. Thorp J. Am. Chem. Soc. 1995, 117, 1463 - 1471. 50. Energy-, Electron-, and Atom-Transfer Reactions between DNA and Metal Complexes. H. H. Thorp Adv. Inorg. Chem. 1995, 43, 127 - 177. 51. Luminescent Labels for Nucleobases: Electronic Properties of Guanine Bound to Re(I). T. A. Oriskovich, P. S. White, H. H. Thorp Inorg. Chem., 1995, 34, 1629 - 1631. 52. Electrochemically Activated Nucleic Acid Oxidation. D. H. Johnston, T. W. Welch, H. H. Thorp Metal Ions Biol. Syst. 1996, 33, 297-324. 53. Excited-State Proton Transfer Reactions of Multiply Bonded Ligands. W. Liu, H. H. Thorp Advances in Transition Metal Coordination Chemistry 1996, 1, 187 - 207. 54. Mg2+-Activated Double-Stranded DNA Cleavage by 4+ {(bpy)2(OH2)RuORu(OH2)(bpy)2] . N. Grover, S. A. Ciftan, H. H. Thorp Inorg. Chim. Acta 1995, 240/1-2, 335 - 338 (Fred Basolo issue). 55. Electrochemical Determination of Nucleic Acid Diffusion Coefficients through Noncovalent Association of a Redox-Active Probe. T. W. Welch, A. H. Corbett, H. H. Thorp J. Phys. Chem. 1995, 99, 11757 - 11763. 6

56. Photochemistry of a Structurally Uncomplicated Phenylcarbyne Complex. S. Trammell, B. P. Sullivan,* L. M. Hodges, W. D. Harman, S. R. Smith, H. H. Thorp Inorg. Chem. 1995, 34, 2791 - 2792. 57. Electrochemical Measurement of the Solvent Accessibility of Nucleobases Using Electron Transfer Between DNA and Metal Complexes. D. H. Johnston, K. C. Glasgow, H. H. Thorp J. Am. Chem. Soc. 1995, 117, 8933 – 8937 58. Photoinduced Proton Transfer Between Transdioxorhenium(V) and Metal Hydrides: A New Method for Quantitating Kinetic Acidities. W. Liu, H. H. Thorp J. Am. Chem. Soc. 1995, 117, 9822 - 9825. 59. An Anionic Diplatinum DNA Cleavage Agent: Chemical Mechanism and Footprinting of Lambda Repressor. K. M. Breiner, M. A. Daugherty, T. G. Oas, H. H. Thorp J. Am. Chem. Soc. 1995, 117, 11673 - 11679. 60. Cleavage of Functionally Relevant Sites in Ferritin mRNA by Oxidizing Metal Complexes. H. H. Thorp,* R. A. McKenzie, P.-N. Lin, W. E. Walden,* E. C. Theil* Inorg. Chem. 1996, 35, 2773 - 2779. 61. Oxidation of DNA by trans-Dioxoruthenium(VI) Complexes: Self-Inhibition of DNA Cleavage by Metal Complexes. J. G. Goll, H. H. Thorp Inorg. Chim. Acta 1996, 242/1-2, 219 - 223 (Harry B. Gray "Festschrift" Issue). 62. Iron Chelates Bind Nitric Oxide and Decrease Mortality in an Experimental Model for Septic Shock. Kazmierski, W. M.; Molina, L.; Wolberg, J.; Wilson, J.; Smith, S. R.; Williams, D. S.; Thorp, H. H. Proc. Natl. Acad. Sci. USA 1996, 93, 9138 - 9141. 63. Oxidation of DNA Hairpins by Oxoruthenium(IV): Effects of Sterics and Secondary Structure. P. J. Carter, C.-C. Cheng, H. H. Thorp* Inorg. Chem. 1996, 35, 3348 - 3354. 64. Distribution of Metal Complexes Bound to DNA Determined by Normal Pulse Voltammetry. T. W. Welch, H. H. Thorp* J. Phys. Chem. 1996, 100, 13829 - 13836. 64a. Ring-opening Metathesis Polymerizations in Carbon Dioxide. C. D. Mistele, H. H. Thorp, J. M. DeSimone J. Macromol. Sci. 1996, A33, 953-960. 65. Cyclic Voltammetry Studies of Polynucleotide Binding and Oxidation by Metal Complexes: Homogenouos Electron-Transfer Kinetics. D. H. Johnston, H. H. Thorp* J. Phys. Chem.1996, 100, 13837 - 13843. 66. Electron-Rich Oxoruthenium(IV) Cleavage Agents: A Zero-Order Rate Law for DNA Catalysis. T. W. Welch, S. A. Ciftan, P. S. White, H. H. Thorp* Inorg. Chem. 1997, 36, 4812-4821. 67. Perfect Strangers: Inorganic Photochemistry and Nucleic Acids. P. J. Carter, S. A. Ciftan, M. F. Sistare, H. H. Thorp J. Chem. Educ. 1997, 74, 641-645. 68. Application of the Electrocatalytic Reduction of Nitric Oxide Mediated by Ferrioxamine B to the Determination of Nitric Oxide Concentrations in Solution. S. R. Smith, H. H. Thorp* Inorg. Chim. Acta (Ivano Bertini issue) 1998, 273, 316- 319. 69. Probing Biomolecule Recognition with Electron Transfer: Electrochemical Sensors for DNA Hybridization. M. E. Napier, C. R. Loomis, M. F. Sistare, J. Kim, A. E. Eckhardt, H. H. Thorp* Bioconjugate Chem. 1997, 8, 906-913. 70. Electron and Hydrogen Transfer Reactions of Nucleotides: From Stern-Volmer Quenching to Nucleoprotein Structure. J. Kim, M. F. Sistare, P. J. Carter, H. H. Thorp* Coord. Chem. Rev. 1998, 171, 341-350. 7

71. Modification of Electrodes with Dicarboxylate Self-Assembled Monolayers for Attachment and Detection of Nucleic Acids. M. E. Napier, H. H. Thorp* Langmuir 1997, 13, 6342-6344. 72. Cutting Out the Middleman: DNA Biosensors Based on Electrochemical Oxidation. H. H. Thorp Trends Biotechnol. 1998, 16, 117 - 121. 73. Oxidation of DNA and RNA by Oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of Dipyridophenazine by High-Resolution Electrophoresis. P. J. Carter, C.-C. Cheng, H. H. Thorp* J. Am. Chem. Soc. 1998, 120, 632-642. 74. Quenching of Guanine Oxidation by Oxoruthenium(IV): Effects of Divalent Cations on Chemical Nuclease Studies. S. A. Ciftan, D. P. Hondros, H. H. Thorp* Inorg. Chem. 1998, 37, 1598-1601. 75. Variable Electronic Coupling Through Hydrocarbon Spacers Bridging Metal-Carbon Triple Bonds. D. S. Frohnapfel, B. E. Woodworth, H. H. Thorp*, J. L. Templeton* J. Phys. Chem. A 1998, 102, 5665-5669. 76. The Effects of Secondary Structure on DNA and RNA Cleavage by Diplatinum(II). P. J. Carter, K. M. Breiner, H. H. Thorp* Biochemistry 1998, 37, 13736-13743. 77. Conformation-Dependent Cleavage of Hairpin and Triplex Nucleic Acids by a Temperature-Insensitive Photonuclease. S. A. Ciftan, H. H. Thorp* J. Am. Chem. Soc. 1998, 120, 9995-10000. 78. Bond Valence Analysis of Metalloenzymes. 3. Predicting Bond Lengths in Adjacent Redox States Using Inner-Sphere Reorganizational Energies. H. H. Thorp Inorg. Chem. 1998, 37, 5690-5692. 79. Bioinorganic Chemistry and Drug Design: Here Comes Zinc Again (Crosstalk). H. H. Thorp Chem. Biol. 1998, 5, R125-R127. 80. Electrocatalytic Oxidation of Nucleic Acids at Electrodes Modified with Nylon and Nitrocellulose Membranes. M. E. Napier, H. H. Thorp* J. Fluorescence 1999, 9, 181-186. 81. Oxidation of Guanines in the Iron Responsive Element RNA: Similar Structures from Chemical Modification and Recent NMR Studies. S. A. Ciftan, E. C. Theil, H. H. Thorp* Chem. Biol. 1998, 5, 679-687. 82. Electrochemical Detection of Single-Stranded DNA using Polymer-Modified Electrodes. A. C. Ontko, P. M. Armistead, S. R. Kircus, H. H. Thorp* Inorg. Chem. 1999, 38, 1842-1846. 83. Driving Force and Isotope Dependence of the Kinetics of Proton-Coupled Electron Transfer in Oxoruthenium(IV) Polypyridyl Complexes. B. T. Farrer, H. H. Thorp* Inorg. Chem. 1999, 38, 2497-2502. 84. Hydride Transfer in Oxidation of Nucleic Acid Sugars: Electronic Effects of 2’- Substituents on Activation of the 1’ C-H Bond by Oxoruthenium(IV). B. T. Farrer, J. S. Pickett, H. H. Thorp* J. Am. Chem. Soc. 2000, 122, 549-553. 85. Site-Selective Electron Transfer from Purines to Electrocatalysts: Voltammetric Detection of a Biologically Relevant Deletion in Hybridized DNA Duplexes. P. A. Ropp, H. H. Thorp* Chem. Biol. 1999, 6, 599-605. 86. Electrochemical Studies of Polynucleotide Binding and Oxidation by Metal Complexes: Effects of Scan Rate, Concentration, and Sequence. M. F. Sistare, R. C. Holmberg, H. H. Thorp* J. Phys. Chem. B. 1999, 103, 10718-10728. 87. Effects of Base Stacking on Guanine Electron Transfer: Rate Constants for G and GG Sequences of Oligonucleotides from Catalytic Electrochemistry. M. F. 8

Sistare, S. J. Codden, G. Heimlich, H. H. Thorp* J. Am. Chem. Soc. 2000, 122, 4742 - 4749. 88. Redox Pathways in DNA Oxidation: Kinetic Studies of Guanine and Sugar Oxidation by Para-Substituted Derivatives of Oxoruthenium(IV). B. T. Farrer, H. H. Thorp* Inorg. Chem., 2000, 39, 44-49. 89. The Importance of Being r: Oxidative Stability of RNA Compared to DNA (Crosstalk). H. H. Thorp* Chem. Biol. 2000, 7, R33-R36. 90. Challenges to Research Universities at the End of the 20th Century. E. L. Eliel, H. H. Thorp Bol. Soc. Chil. Quim. 2000, 44, 393-397. 91. Electron Transfer in Tetrads: Adjacent Guanines are not Hole Traps in G Quartets. V. A. Szalai, H. H. Thorp* J. Am. Chem. Soc. 2000, 122, 4524-4525. 92. Modification of Metal Oxides with Nucleic Acids: Detection of Attomole Quantities of Immobilized DNA by Electrocatalysis. P. M. Armistead, H. H. Thorp* Anal. Chem. 2000, 72, 3764-3770. 93. Electrocatalysis of Guanine Electron Transfer: New Insights from Submillimeter Carbon Electrodes. V. A. Szalai, H. H. Thorp* J. Phys. Chem. B 2000, 104, 6851- 6859. 94. Kinetics of Metal-Mediated, One-Electron Oxidation of Guanine in Polymeric DNA and Oligonucleotides Containing Trinucleotide Repeat Sequences. I. V. Yang, H. H. Thorp* Inorg. Chem. 2000, 39, 4969-4976. 95. An Ionic Liquid Form of DNA: Redox-Active Molten Salts of Nucleic Acids. A. M. Leone, S. C. Weatherly, M. E. Williams, R. W. Murray*, H. H. Thorp* J. Am. Chem. Soc. 2001, 123, 218-222. 96. Ethanol Oxidation by Imidorhenium(V) Complexes: Formation of Amidorhenium(III). A. L. Suing, C. R. Dewan, P. S. White, H. H. Thorp* Inorg. Chem. 2000, 39, 6080-6085. 97. Oxidation Kinetics of Guanine in DNA Molecules Adsorbed to Indium Tin Oxide Electrodes. P. M. Armistead, H. H. Thorp* Anal. Chem. 2001, 73, 558-564. 98. Harnessing the Power of Diatomics (Perspective). H. H. Thorp* Science 2000, 289, 882-883. 99. Proton-Coupled Electron Transfer in Duplex DNA: Driving Force Dependence and Isotope Effects on Electrocatalytic Oxidation of Guanine. S. C. Weatherly, I. V. Yang, H. H. Thorp* J. Am. Chem. Soc. 2001, 123, 1236-1237. 100. Oxidation of 7-Deazaguanine: Mismatch-Dependent Electrochemistry and Selective Strand Scission. I. V. Yang, H. H. Thorp* Inorg. Chem. 2001, 40, 1690- 1697. 101. Electrochemical Detection of Gene Expression in Tumor Samples: Overexpression of Rak Nuclear Tyrosine Kinase. P. M. Armistead, H. H. Thorp* Bioconjugate Chem. 2002, 13, 172-176. 102. Modification of Indium Tin Oxide Electrodes with Repeat Polynucleotides: Electrochemical Detection of Trinucleotide Repeat Expansion. I. V. Yang, H. H. Thorp* Anal. Chem. 2001, 73, 5316-5322. 103. Using Density Functional Theory to Design DNA Base Analogues with Low Oxidation Potentials. M.-H. Baik, J. S. Silverman, I. V. Yang, P. A. Ropp, V. A. Szalai, W. Yang, H. H. Thorp* J. Phys. Chem. B 2001, 105, 6537-6444. 104. Digital Simulation of Catalytic Cyclic Voltammograms for Oxidation of DNA by a Heterobimetallic Dimer: Effects of DNA Binding and Mass Transport. R. C. Holmberg, H. H. Thorp* Anal. Chem. 2003, 75, 1851-1860. 9

105. Electrocatalysis of Guanine Oxidation in Polyethylene Glycol Solutions: The Interplay of Adsorption and Reaction Rate. V. A. Szalai, J. Jayawickamarajah, H. H. Thorp* J. Phys. Chem. B 2002, 106, 709-716. 106. Site-Specific Probing of Oxidative Reactivity and Telomerase Function Using 7,8- Dihydro-8-Oxoguanine in Telomeric DNA. V. A. Szalai, M. J. Singer, H. H. Thorp* J. Am. Chem. Soc. 2002 124, 1625-1631. 107. Towards Electrochemical Resolution of Two Genes on One Electrode: Using 7- Deaza Analogs of Guanine and Adenine to Prepare PCR Products with Differential Redox Activity. I. V. Yang, P. A. Ropp, H. H. Thorp* Anal. Chem. 2002, 74, 347- 354. 108. Electrochemical Detection of Nucleic Acids. A. Eckhardt, E. Espenhahn, M. Napier, N. Popovich, H. Thorp, R. Witwer In DNA Arrays: Technologies and Experimental Strategies; E. V. Grigorenko, Ed.; CRC Press: Boca Raton, 2001, pp. 39-60. 109. Metal Ligand Charge-Transfer Promoted Photo-Electronic Bergman Cyclization of Copper Metallo-Enediynes: Photochemical DNA Cleavage Via C-4’ H- Abstraction. P. J. Benites, R. C. Holmberg, D. S. Rawat, B. J. Kraft, L. J. Klein, D. G. Peters, H. H. Thorp,* J. M. Zaleski* J. Am. Chem. Soc., 2003, 125, 6434- 6446. 110. Photoinduced Electron Transfer in Nucleic Acid Molten Salts. A. M. Leone, M. K. Brennaman, J. D. Tibodeau, J. M. Papanikolas, R. W. Murray, H. H. Thorp J. Phys. Chem. B, 2003, 107, 6469-6473. 111. Proton-Coupled Electron Transfer in Guanine Oxidation: Effects of Isotope, Solvent, and Chemical Modification. S. C. Weatherly, I. V. Yang, P. M. Armistead, H. H. Thorp* J. Phys. Chem. B 2003, 107, 372-378. 112. New Strategies for Electrochemical Nucleic Acid Detection. N. D. Popovich, H. H. Thorp* Interface 2002, 11, 30-34. 113. Intramolecular Electrocatalysis of 8-oxo-Guanine Oxidation: Secondary Structure Control of Electron Transfer in Osmium-Labeled Oligonucleotides. R. C. Holmberg, M. T. Tierney, E. E. Berg, M. W. Grinstaff, H. H. Thorp* Inorg. Chem., 2003, 42, 6379-6387. 114. Electrocatalytic DNA Oxidation. H. H. Thorp Topics Curr. Chem., 2004, 237, 159- 171. 115. Ion Atmosphere Relaxation Induced Percolative Electron Transfer in Co Bipyridine DNA Molten Salts. A. M. Leone, J. D. Tibodeau, S. H. Bull. S. W. Feldberg, H. H. Thorp, R. W. Murray J. Am. Chem. Soc. 2003, 125, 6784-6790. 116. Detection of Attomole Quantities of DNA Targets on Gold Microelectrodes by Electrocatalytic Nucleobase Oxidation. M. S. Gore, V. A. Szalai, P. A. Ropp, I. V. Yang, J. S. Silverman, H. H. Thorp Anal. Chem. 2003, 75, 6586-6592. 117. Probing the Solvent Accessibility and Electron Density of Adenine: Oxidation of 7-Deazaadenine in Bent DNA and Purine Doublets. J. D. Tibodeau, H. H. Thorp* Inorg. Chem. 2004, 43, 408-410. 118. Reagentless Detection of DNA Sequences on Chemically Modified Electrodes (Research Focus). H. H. Thorp* Trends Biotechnol. 2003, 21, 522-524. 119. Electrochemical Determination of Triple Helices: Electrocatalytic Oxidation of Guanine in an Intramolecular Triplex. R. C. Holmberg, H. H. Thorp* Inorg. Chem. 2004, 43, 5080-5085. 10

120. Electrochemistry: Applications in Inorganic Chemistry. H. H. Thorp Encyclopedia of Inorganic Chemistry, R. H. Crabtree, Ed., Wiley: New York, submitted 2/04. 121. Electrocatalysis in Nucleic Acid Molten Salts. A. M. Leone, D. O. Hull, W. Wang, H. H. Thorp*, R. W. Murray* J. Phys. Chem. A 2004, 108, 9787-9783. 122. Using RNA Oxidation to Find Site-Selective Binders: Small Molecules that Target RNA and Upregulate Ferritin Synthesis. J. D. Tibodeau, P. M. Fox, P. A. Ropp, E. C. Thiel,* H. H. Thorp* Proc. Natl. Acad. Sci., USA 2006, 103, 253-257. 123. Coordinate or Be Coordinated: Dynamic Relationships Between Metal Ions and Biological Macromolecules. H. H. Thorp, E. C. Theil Curr. Opin. Chem. Biol. 2005, 9, 95-96. 124. Electrocatalytic Oxidation of DNA-Wrapped Carbon Nanotubes. M. E. Napier, D. O. Hull, H. H. Thorp* J. Am. Chem. Soc. 2005, 127, 11952-11953. 125. Effects of Coordinating Metal Ions on the Mediated Inhibition of Trypsin by Bis- benzimidazoles and Related Compounds. J. J. Paul, S. R. Kircus, P. A. Ropp, T. N. Sorrell, H. H. Thorp* Inorg. Chem. 2006,45, 5126-5135. 126. The Role of Proton-Coupled Electron Transfer (PCET) in Photosystem II. Wiring for Protons. T. J. Meyer,* M.-H. Huynh, H. H. Thorp Angew. Chem. Int. Ed. Engl. 2007, 46, 5284-5304. 127. Electrocatalytic Oxidation of Tyrosine in Water by Partitioning between Rate- Limiting Proton Transfer and Multi-Site Electron-Proton Transfer. C. J. Fecenko, T. J. Meyer,* H. H. Thorp* J. Am. Chem. Soc. 2006, 128, 11020-11021. 128. The Role of Free Energy in Coupled Electron-Proton Transfers. C. J. Fecenko, H. H. Thorp,* T. J. Meyer J. Am. Chem. Soc. 2007, 129, 15098-15099. 129. Atomic Force Microscopy Studies of DNA-Wrapped Carbon Nanotube Structure and Binding to Quantum Dots. J. F. Campbell, I. Tessmer, H. H. Thorp, D. A. Erie J. Am. Chem. Soc., revisions submitted 6/08.

Patents: 1. “Process of Cleaving Nucleic Acids with Oxoruthenium(IV) Complexes;” H. H. Thorp, N. Grover; U. S. Patent No. 5,171,853. 2. “Electrochemical Method of Detecting Nucleic Acid Hybridization,” H. H. Thorp, D. H. Johnston, M. E. Napier, C. Loomis, M. F. Sistare, J. Kim; U.S. Patent No. 5,871,918; New Zealand Patent No. 311955; Australian Patent No. 724600; European Patent No. 0817113; Italian Patent No. 0871773; British Patent No. 0871773; French Patent No. 0871773; German Patent No. 69623494.7; Japanese Patent No. 3847745. 3. “Polymer-Electrodes for Detecting Nucleic Acid Hybridization and Method of Use Thereof,” H. H. Thorp, C. R. Loomis, M. E. Napier; US Patent No. 5,968,745. 4. “Microelectronic Device,” H. H. Thorp et al., H. H. Thorp, D. H. Johnston, M. E. Napier, C. Loomis, M. F. Sistare, J. Kim; U.S. Patent No. 6,132,971; Australian Patent No. 753350. 5. “Monolayer and Electrode for Detecting a Label-Bearing Target and Method of Use Thereof,” A. E. Eckhardt, J. C. Mikulecky, M. E. Napier, R. S. Thomas, H. H. Thorp, US Patent No. 6,127,127; New Zealand, 514682, Australian Patent No. 781085. 6. “Electrochemical Probes for Detection of Molecular Interactions and Drug Discovery,” D. Fowlkes, H. H. Thorp, Australian Patent No. 729118. 7. “Electropolymerizable Film, and Method of Making and Use Thereof,” H. H. Thorp, A. C. Ontko, US Patent No. 6,180,346; New Zealand No. 513604; Australia No. 775533, Mexican Patent No. 228842. 11

8. “Detection of Binding Reactions Using Labels Detected by Mediated Catalytic Electrochemistry,” D. H. Stewart, J. W. Groelke, H. H. Thorp, A. E. Eckhardt, US Patent No. 6,346,387. 9. “Monolayer and Electrode for Detecting a Label-Bearing Target and Method of Use Thereof (Continuation of 6,127,127),” A. E. Eckhardt, J. C. Mikulecky, M. E. Napier, R. S. Thomas, H. H. Thorp, US Patent No. 6,387,625; New Zealand Patent No 513604. 10. “Electrochemical Method of Detecting Nucleic Acid Hybridization (Divisional of 5,871,918),” H. H. Thorp, D. H. Johnston, M. E. Napier, C. Loomis, M. F. Sistare, J. Kim; US Patent No. 6,361,951. 11. "Electrical Devices Employing Molten Compositions of Biomolecules"; H. H. Thorp; R. W. Murray; A. M. Leone; M. E. Williams, US Patent 7,033,664; Australia Application No. 2001290538; Canada Application No. 2,419,226. 12. “Microelectronic Device for Electrochemical Detection of Nucleic Acid Hybridization,” H. H. Thorp, D. H. Johnston, M. E. Napier, C. R. Loomis, M. R. Sistare, J. Kim, US Patent No. 7,049,068 B2. 13. "Compositions of Nucleic Acids that Form Molten Phases and Methods of Use Thereof"; H. H. Thorp; R. W. Murray; A. M. Leone; M. E. Williams; PCT filed August 17, 2001; EPO publication WO 02/22711 A2; Australian Patent No. 2001290538. 14. “Method for Electrochemical Detection of Multiple Target Compounds”; H. H. Thorp, I. V. Yang, D. H. Stewart, J. W. Groelke; US Patent No. 7,202,028; WO 03/089895; Australia, Serial Number 2002367807. 15. “Detection of Binding Reactions Using Labels Detected by Mediated Catalytic Electrochemistry,” D. H. Stewart, J. W. Groelke, H. H. Thorp, A. E. Eckhardt (Continuation of 09/722,065), US S/N 09/991,015, Filed December 2001. 16. “Methods for Electrochemical Detection of Target Compounds,” M. S. Gore, H. H. Thorp, U. S. Application Filed March 2004 (US 2005/0123937A1), PCT Filed March 2004, WO 2004/092708. 17. “Electrocatalytic Detection of Carbon Nanotubes,” M. E. Napier, D. O. Hull, H. H. Thorp, U.S. Provisional Application Filed July 2005 (US Application No. 60/703841). 18. “Screening for Modulators of Metalation Pathways for Metalloproteins,” T. V. O’Halloran, H. H. Thorp, U.S. Provisional Application Filed Oct 20, 2005 (US Provisional Application Serial No. 60/729,183). 19. “Compositions and Methods of Screening Apoproteins,” T. V. O’Halloran, H. H. Thorp, U.S. Provisional Application Filed Oct 20, 2005 (US Provisional Application Serial No. 60/728,840).

Edited Book: "Mechanistic Bioinorganic Chemistry," Advances in Chemistry Series, No. 246, ACS Books, H. H. Thorp and V. L. Pecoraro, Eds., 1995, ISBN 0-8412-3062-5, 400 pp.

Selected Invited Chemistry Lectures: 103. DNA Sensors Symposium, 199th Meeting of the Electrochemical Society, Washington, DC, March 2001. 104. Symposium honoring Harry Gray, 221st National Meeting of the American Chemical Society, San Diego, California, April 2001. 105. NASA Ames Research Center, Mountain View, CA, May 2001. 12

106. Inorganic Chemistry into the New Millennium, Santa Fe, NM, May 2001. 107. American Society for Photobiology, DNA Photochemistry Symposium, Chicago, July 2001. 108. International Conference on Bioinorganic Chemistry 10, Florence, August 2001. 109. Department of Chemistry, Wake Forest University, October 2001. 110. Department of Chemistry, University of Nebraska, December 2001. 111. Department of Chemistry, Case Western Reserve University, January 2002. 112. Department of Chemistry, North Carolina State University, February 2002. 113. Department of Chemistry, University of Connecticut, February 2002. 114. Department of Chemistry, Yale University, February 2002. 115. Department of Chemistry, University of New Mexico, May 2002. 116. Los Alamos National Laboratory, May 2002. 117. Middlebury College, September 2002. 118. Electrochemical Biosensors Workshop, Army Research Laboratory, Adelphi, MD, September 2002. 119. Department of Chemistry, University of Michigan, February 2003. 120. Pittcon Annual Conference on Analytical Chemistry and Spectroscopy, Orlando, March 2003. 121. Department of Chemistry, University of Missouri, October 2003. 122. Symposium on DNA Electron Transfer, SERMACS Annual Meeting, Atlanta, November 2003. 123. Department of Chemistry, University of South Carolina, January 2004. 124. Annual Symposium on Chemistry and Biochemistry, UNC-Wilmington, January 2004. 125. Department of Chemistry, Duke University, March 2004. 126. Department of Chemistry, Ohio State University, April 2004. 127. New York Academy of Sciences, April 2004. 128. Department of Chemistry, Indiana University, April 2005. 129. Symposium on Inorganic Approaches to Chemotherapy, ACS National Meeting, Washington, DC, August 2005. 130. Summit on Facilities for the Emerging Sciences, St. Petersburg, FL, April 2006. 131. Department of Chemistry, University of Pennsylvania, April 2006. 132. Department of Chemistry, Virginia Commonwealth University, October 2006. 133. London Scientific Lecture, Simon Fraser University, November 2006. 134. Department of Chemistry, University of Maryland, Baltimore County, November 2006. 135. Department of Chemistry, Florida International University, February 2007.

Funded research proposals: 1. New Faculty Award, Camille and Henry Dreyfus Foundation, $25,000, September 1990 - August 1995. 2. "Chemically Modified Electrodes: New Model Systems for Redox Metalloenzymes," Petroleum Research Fund, $21,000, September 1991 - August 1993. 13

3. Presidential Young Investigator Award, National Science Foundation, $312,500, September 1991 - August 1996. 4. "Electrode Surfaces That Bind DNA: Microscopic Reactors for Studying the Biochemistry and Biophysics of Small Molecules Bound to the Double Helix," North Carolina Biotechnology Center, $40,000, September 1991 - February 1993. 5. "New Ru and Os Reagents for Cancer Chemotherapy," Burroughs-Wellcome Company, $48,040, September 1991 - August 1992. 6. David and Lucile Packard Fellowship for Science and Engineering, The David and Lucile Packard Foundation, $500,000, October 1991 - September 1996. 7. "Rational Design of Luminescent Excited-State Probes Based on Dioxorhenium(V)." N. C. State Faculty Research and Professional Development Fund, $3500, January 1992 - December 1992. 8. "Synthesis of Re(V) Complexes from Perrhenate." Burroughs-Wellcome Company, $10,360, August 1992 - February 1993. 9. "Excited-State Proton Transfer in Transdioxorhenium(V)." Petroleum Research Fund, $50,000, February 1993 - August 1995. 10. "Reduction of Perrhenate Using Chaperone Ligands." Burroughs-Wellcome Co., $48,997, April 1993 - October 1994. 11. Unrestricted grant, Bioxy, Inc., $9,000, October 1993 - December 1993. 12. Junior Faculty Development Award, University of North Carolina, $3000, Fall 1993. 13. "Radiolabeling of Chelator-Antibody Conjugates with Rhenium." Burroughs- Wellcome Co., $61,152, November 1994 - December 1995. 14. "Excited-State Proton Transfer in Transdioxorhenium(V)." Petroleum Research Fund, $50,000, September 1995 - August 1997. 15. Camille Dreyfus Teacher-Scholar Award, Camille and Henry Dreyfus Foundation, $60,000, July 1995 - June 2000. 16. Alfred P. Sloan Fellowship, Alfred P. Sloan Foundation, $35,000, April 1996 - March 1998. 17. "Environmentally Benign Asymmetric Epoxidation." National Science Foundation and Hoechst-Celanese Corporation, $95,000, July 1996 - December 1997. 18. "Electrochemical Screening of Combinatorial Libraries." Novalon Pharmaceutical Corporation, $30,294, October 1996 - August 1997. 19. "Detection of DNA and RNA Sequences." Xanthon, Inc., $600,000, September 1996 - August 1999. 20. "Applications of a Novel Nucleic Acid Detection Method in Cancer: Mutation and Overexpression Analysis," Lineberger Comprehensive Cancer Center Breast Cancer SPORE, $20,000, July 1997 - June 1998. 21. "An Internet Approach to Building Quantitative Skills and Enhancing Faculty- Student Contact in General Chemistry," UNC General Administration, $44,160, May 1997. 22. "Effects of Base Flipping on Guanine-Metal Electron Transfer," NSF, $239,472, August 1997 – January 2000. 23. “Chemical Modification of Peptides and Proteins,” Novalon Pharmaceutical Corporation, $30,000, August 1997 - July 1998. 24. “The Role of Rak in Breast Cancer,” US Army Medical Research and Materiel Command, $60,000, January 1998 - December 2000. 14

25. “Applications of a Novel Nucleic Acid Detection Method in Breast Cancer: Analysis of Overexpression of HER-2/neu and FAK,” US Army Medical Research and Materiel Command, $294,550, July 1998 - June 2001. 26. “An Exemplary Internet Course In Quantitative Skills Preparation,” UNC Chancellor’s Task Force For Instructional Technology, $75,000, November 1997 - July 1998. 27. “Detection of DNA and RNA Sequences by Guanine Electron Transfer,” Xanthon, Inc., $300,918, September 1999 – August 2000. 28. Postdoctoral Fellowship: Veronika A. Szalai, National Institutes of Health, $31,720, December 1999 – November 2000. 29. “Detection of DNA and RNA Sequences by Guanine Electron Transfer,” Xanthon, Inc., $345,388, September 2000 – August 2001. 30. Fabrication and Interrogation of Miniaturized DNA Electrodes, North Carolina Biotechnology Center and Xanthon, Inc., $176,900, February 2001 – January 2003 (co-PI with Michael Pirrung, Duke University). 31. “Detection of DNA and RNA Sequences by Guanine Electron Transfer,” Xanthon, Inc., $239,357, September 2001 – August 2002. 32. Graduate Fellowship: Mitchell Gore, National Center for Human Genome Research, $98,916, April 2002 – March 2006. 33. “Electrochemical Detection of DNA and RNA,” Motorola, Inc., $1,038,000, January 2003 – December 2005. 34. “Fe, O2, mRNA and Ferritin in Vitro and in Cells,” National Institutes of Health, co- PI, $408,000, August 2003 – July 2008. 35. “Integrated Nanofluidic Electronic Sensor Technologies for Army Applications,” US Army, co-PI, Sept 2005 – Aug 2008, $4,500,000; Thorp share: $239,000. 36. “New Inhibitors of Metallobetalactamase,” Viamet Pharmaceuticals, Inc., October 2005 – September 2006, $131,312. 37. “Minor in Scientific Entrepreneurship,” CEI Innovations Fund, April 2006, $42,403.