H. Holden Thorp Dean, College of Arts and Sciences Kenan Professor of Chemistry Chancellor-Elect Address: College of Arts and Sciences University of North Carolina Chapel Hill, NC 27599-3100 (919)962-3082 Academic Positions: Department of Chemistry, North Carolina State University: Assistant Professor (January 1991 - June 1993). Department of Chemistry, University of North Carolina at Chapel Hill: Visiting Assistant Professor (January - June 1993), Assistant Professor (July 1993 - December 1995), Associate Professor (January 1996 – June 1999), Vice-Chair for Undergraduate Studies (July 1995 – June 2000), Member of the Lineberger Comprehensive Cancer Center (January 1997 - present), Professor (July 1999 – June 2005); Kenan Professor (July 2005 – present); Department Chair (July 2005 – May 2007); Faculty Director of Fundraising, Carolina Physical Science Complex (2003 – 2007). Morehead Planetarium and Science Center, University of North Carolina at Chapel Hill: Director (August 2001 – June 2005). College of Arts and Sciences, University of North Carolina at Chapel Hill: Dean (July 2007 – June 2008). Chancellor, University of North Carolina at Chapel Hill: (beginning July 2008) Education: Post-doctoral: Yale University (July 1989 - December 1990) Advisor: Gary W. Brudvig Graduate: California Institute of Technology (1986 - 1989) Ph.D. Chemistry - June 1989 Graduate research advisor: Harry B. Gray Undergraduate: University of North Carolina - Chapel Hill (1982 - 1986) B.S. Chemistry - May 1986 Undergraduate research advisor: Thomas J. Meyer Fellowships and Honors: London Scientific Lecturer (Simon Fraser University – 2006), Kenan Professorship (2004), UNC General Alumni Association Distinguished Young Alumnus (2002), Honorary Member of the Order of the Golden Fleece (2002), Fortune Small Business Top Innovators of 2001, CED Life Science Technology of the Year (2000), NAS Frontiers of Science Participant (1999), Tanner Award for Excellence in Undergraduate Teaching (1998), Ruth and Philip Hettleman Prize for Artistic and Scholarly Achievement (1996), Alfred P. Sloan Fellowship (1996), Camille Dreyfus Teacher-Scholar (1995), David and Lucile Packard Fellowship for Science and Engineering (1991), NSF Presidential Young Investigator (1991), Camille and Henry 2 Dreyfus New Faculty Award (1990), National Science Foundation Graduate Fellowship (1987). Professional Activities: Co-Editor, Bioinorganic Chemistry issue, Current Opinion in Chemical Biology (2005); Sigma Xi Committee on Science in the Public Interest (2004 – 2007); Board of Directors, North Carolina Center for Science, Math, and Technology Education (2002 – 2007); NIH Metallobiochemistry Study Section (February 1999, October 1999); NIH Special Emphasis Panel on SBIR and STTR Grants (November 2001, March 2003); NASA Advanced Monitoring and Control Peer Review Panel (July 2000). Industry activities: Co-Founder and Scientific Advisory Board, Viamet Pharmaceuticals (2005 – present); Scientific Advisory Board, OhmX, Inc. (2005 – present); Technical Advisory Board, Plextronics, Inc. (2007 – present); Consultant, Firelake Capital (2005 – present); Consultant, Osmetech, Inc. (2005 – present); Venture Partner, Hatteras Venture Partners (2007 – present); Consultant, Clinical Micro Sensors, A Motorola Company (2003 – 2005); Scientific Advisory Board, MaxCyte, Inc. (2004 – 2006); Chair of Scientific Advisory Board, Director, and Founder, Xanthon, Inc. (1996 – 2002); President, Xanthon, Inc. (2002 – 2005); Scientific Advisory Board, Novalon Pharmaceutical Corporation, (1996 – 1999); Consultant, NeXstar Pharmaceuticals (1995); Consultant, Burroughs-Wellcome Co. (1993 – 1996). Selected public talks: UNC December Commencement (2006); Cum Laude Address, Episcopal High School (2007); Carolina United Keynote Address (2007); Carolina Challenge Celebration (2007); Carolina Union Last Lecture (1999), Carolina Scholars Banquet (2001), NC District 7 Leadership Summit (2003, 2005), Governor’s School West (2003), “Happy Birthday DNA,” Annual Meeting of the Association of Science and Technology Centers (2003); Dupont Appreciation Day, Methodist College (2003); Panel on the Future of the University, 100th Anniversary of the Order of the Golden Fleece (2004); Phi Beta Kappa Induction, UNC-Greensboro (2004). Publications: 1. Electrocatalytic Carbon Dioxide Reduction. B. P. Sullivan, M. R. M. Bruce, T. R. O'Toole, C. M. Bolinger, E. Megehee, H. Thorp, T. J. Meyer ACS Symp. Ser. 1988, 363, 52. 2. Electrocatalytic Reduction of CO2 by Associative Addition. M. R. M. Bruce, E. Megehee, B. P. Sullivan, H. Thorp, T. R. O'Toole, A. Downard, T. J. Meyer Organometallics 1988, 7, 238. 3. Excited-State Properties of Dioxorhenium(V). Generation and Reactivity of Dioxorhenium(VI). H. H. Thorp, J. Van Houten, H. B. Gray Inorg. Chem. 1989, 28, 889. 4. Emission Properties of Dioxorhenium(V) Complexes in Aqueous Solutions of Anionic and Nonionic Surfactants: A Sensitive Probe of Hydrophobic Binding Regions. H. H. Thorp, C. V. Kumar, N. J. Turro, H. B. Gray J. Am. Chem. Soc. 1989, 111, 4364. 3+ 5. Proton-Coupled Electron Transfer in [(bpy)2Mn(O)2Mn(bpy)2] . H. H. Thorp,* J. E. Sarneski, G. W. Brudvig, R. H. Crabtree J. Am. Chem. Soc. 1989, 111, 9249. 3 3+ 6. Proton-Coupled Electron Transfer in [(bpy)2Mn(O)2Mn(bpy)2] . Role of the Electrode Surface. H. H. Thorp,* E. F. Bowden, G. W. Brudvig J. Electroanal. Chem. 1990, 290, 293. 7. Assembly of High-Valent Oxomanganese Clusters in Aqueous Solution. Redox 4+ 3+ Equilibrium of Water-Stable Mn3O4 and Mn2O2 Complexes. J. E. Sarneski, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree, G. K. Schulte J. Am. Chem. Soc. 1990, 112, 7255. 8. The Physical Inorganic Chemistry of Manganese Relevant to Photosynthetic Oxygen Evolution. H. H. Thorp, G. W. Brudvig New J. Chem. 1991, 15, 479. 9. Proton-Coupled Electron Transfer in Oxomanganese Dimers: Role of the Ancillary Ligands. R. Manchanda, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree Inorg. Chem. 1991, 30, 494. 10. Physical Properties of a Manganese Tetramer with All-Oxygen Coordination. H. H. Thorp, J. E. Sarneski, R. J. Kulawiec, G. W. Brudvig, R. H. Crabtree, G. C. Papaefthymiou Inorg. Chem. 1991, 30, 1153. 11. The Photochemistry of Dioxorhenium(V) Complexes in DNA: Multiple Binding Regions and Oxidative Cleavage. H. H. Thorp, N. J. Turro, H. B. Gray New J. Chem. 1991, 15, 601 - 604. 12. Electronic Structure of trans-Dioxorhenium(VI). J. C. Brewer, H. H. Thorp, K. M. Slagle, G. W. Brudvig, H. B. Gray J. Am. Chem. Soc. 1991, 113, 3171. 13. Alkyl Hydroperoxide Oxidation of Alkanes and Alkenes with a Highly Active Mn Catalyst. J. E. Sarneski, D. Michos, H. H. Thorp, M. Didiuk, T. Poon, G. W. Brudvig, R. H. Crabtree Tet. Lett. 1991, 32, 1153. 14. Photophysics of Dioxorhenium(V) in Nafion. H. H. Thorp, H. B. Gray Photochem. Photobiol. 1991, 54, 609. 15. A High-Valent Oxomanganese Cluster Containing Inorganic Phosphate. J. E. Sarneski, M. Didiuk, H. H. Thorp, G. W. Brudvig, R. H. Crabtree, J. W. Faller, G. K. Schulte Inorg. Chem. 1991, 30, 2833. 16. Efficient Electrocatalytic and Stoichiometric Cleavage of DNA by Oxoruthenium(IV). N. Grover, H. H. Thorp J. Am. Chem. Soc. 1991, 113, 7030 - 7031. 17. Temperature-Dependent Cyclic Voltammetry of Oxo-Bridged Dimers of Relevance to Photosynthetic Water Oxidation. W. A. Kalsbeck, H. H. Thorp,* G. W. Brudvig J. Electroanal. Chem. 1991, 314, 335 - 343. 4- 18. Photolytic Cleavage of DNA by Pt2(pop)4 . W. A. Kalsbeck, N. Grover, H. H. Thorp Angew. Chem. Int. Ed. Engl. 1991, 30, 1517 - 1518. 19. Electrochemical Reduction of Fullerenes in the Presence of O2 and H2O: Polyoxygen Adducts and Fragmentation of the C60 Framework. W. A. Kalsbeck, H. H. Thorp J. Electroanal. Chem. 1991, 314, 363 - 370. 20. Electrochemistry of Proton-Coupled Redox Reactions: Role of the Electrode Surface. H. H. Thorp J. Chem. Educ. 1992, 69, 250 - 252. 21. Proton-Coupled Electron Transfer in Metal Complexes: Applications in Catalysis, Molecular Electronics, and Biochemistry (Feature Article). H. H. Thorp Chemtracts: Inorganic Chemistry, 1991, 3, 171 - 184. 22. Probing the Mechanism of Water Oxidation by Photosystem II. G. W. Brudvig,* H. H. Thorp, R. H. Crabtree Acc. Chem. Res., 1991, 24, 311 - 316. 4 23. Studies of Electrocatalytic DNA Cleavage by Oxoruthenium(IV). X-Ray Crystal Structure of [Ru(tpy)(tmen)OH2](ClO4)2 (tmen = N,N,N',N'- tetramethylethylenediamine, tpy = 2,2',2''-terpyridine). N. Grover, N. Gupta, P. Singh, H. H. Thorp Inorg. Chem. 1992, 31, 2014 - 2020. 24. Binding of Alkali Cations by Self-Assembling Ionophore Complexes of Ni(II). M. W. Jones, N. Gupta, A. Schepartz, H. H. Thorp Inorg. Chem. 1992, 31, 1308 - 1310. 25. Stereoselective Covalent Binding of Aquaruthenium(II) Complexes to DNA. N. Grover, N. Gupta, H. H. Thorp J. Am. Chem. Soc. 1992, 114, 3390 - 3393. 26. Bond Valence Sum Analysis of Metal-Ligand Bond Lengths in Metalloenzymes and Model Complexes. H. H. Thorp Inorg. Chem. 1992, 31, 1585 - 1588. 27. Toward a Functional Model of Hydrogenase: Electrocatalytic Reduction of Protons by a Ni Macrocyclic Complex. L. L. Efros, H. H. Thorp,* G. W. Brudvig, R. H. Crabtree Inorg. Chem. 1992, 31, 1722 - 1724. 28. Ru(tpy)(dppz)O2+: A High-Affinity DNA Cleavage Reagent. N. Gupta, N. Grover, G. A. Neyhart, W. Liang, P. Singh, H. H. Thorp Angew. Chem. Int. Ed. Engl. 1992, 31, 1048 - 1050. 29. An Unusual Example of Multiple Proton-Coupled Electron Transfers in a High- III IV Valent Oxomanganese Dimer, [(phen)2Mn (O)2Mn (phen)2](ClO4)3 (phen = 1,10-phenanthroline). R. Manchanda, H. H. Thorp, G. W. Brudvig,* R. H. Crabtree Inorg. Chem. 1992, 31, 4040 - 4041. 30. Excited-State Proton Transfer in Transdioxorhenium(V). W. Liu, T. W. Welch, H. H. Thorp Inorg. Chem. 1992, 31, 4044 - 4045. 31. New Mechanisms in DNA Cleavage by Metal Complexes. H. H. Thorp J. Inorg. Organomet. Polymers 1993, 3, 111 - 157. 32. Synthesis and Properties of New DNA Cleavage Agents Based on Oxoruthenium(IV). N. Gupta, N. Grover, G. A. Neyhart, P. Singh, and H. H. Thorp Inorg. Chem. 1993, 32, 310 - 316. 33. Electrocatalytic Reduction of Carbon Dioxide Based on 2,2'-Bipyridyl Complexes of Osmium. M. R. M. Bruce, E. Megehee, B. P. Sullivan,* H. H. Thorp, T. R. O'Toole, A. Downard, R. R. Pugh, T. J. Meyer* Inorg.