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Nektarios Tavernarakis (Ed.) Protein and in Aging Series: Advances in Experimental Medicine and

Illustrates that aging cells are characterized by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation is controlled at multiple levels Discusses paradoxical situation of up-regulation in models of premature aging Role of mitochondria in protein quality control and the influence of reactive oxygen species Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal 2010, XXI, 249 p. maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is Printed book provided of the current knowledge in the area, including protein synthesis, accuracy and repair, Hardcover post-translational modifications, degradation and turnover, and how they define and influence 199,99 € | £179.99 | $249.99 aging. The chapters mainly focus on well-characterised factors and pathways, but new areas [1]213,99 € (D) | 219,99 € (A) | CHF are also presented, where associations with aging are just being elucidated by current 236,00 experimental data. Protein turnover, the balance between protein synthesis and protein Softcover degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging 186,90 € | £139.99 | $219.99 cells are characterised by alterations in the rate, level and accuracy of protein synthesis [1]199,98 € (D) | 205,59 € (A) | CHF compared to young ones, and that mRNA translation, essential for cell growth and survival, is 220,50 controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in eBook decreased rates of growth and development, but also confers an extension of lifespan, as 149,79 € | £111.50 | $169.00 shown for example by the effects of dietary restriction in various models organisms. [2]149,79 € (D) | 149,79 € (A) | CHF 176,00 Available from your library or springer.com/shop MyCopy [3] Printed eBook for just € | $ 24.99 springer.com/mycopy

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