MOLECULAR AND CELLULAR BIOLOGY VOLUME 13 * DECEMBER 1993 * NUMBER 12

Alan M. Weiner, Editor in Chief (1995) Tom Kadesch, Editor (1996) George F. Sprague, Jr., Editor (1998) Yale University University ofPennsylvania School University of Oregon ofMedicine James C. Alwine, Editor (1998) Shirley M. Tilghman, Editor (1998) University ofPennsylvania School of Robert E. Kingston, Editor (1997) Princeton University Medicine Massachusetts General Hospital Jonathan R. Warner, Editor (1998) James R. Broach, Editor (1995) Adrian R. Krainer, Editor (1998) Albert Einstein College ofMedicine Princeton University Cold Spring Harbor Laboratory Lawrence A. Chasin, Editor (1995) Michael J. Weber, Editor (1997) Columbia University Douglas Lowy, Editor (1998) University of Virginia Medical National Institutes ofHealth School Nouria Hernandez, Editor (1998) Cold Spring Harbor Laboratory Charles J. Sherr, Editor (1995) Elton T. Young, Editor (1998) St. Jude Children's Research Hospital University of Washington Anita K. Hopper, Editor (1994) The Milton S. Hershey Medical Center Nahum Sonenberg, Editor (1998) Kenneth S. Zaret, Editor (1998) Pennsylvania State University McGill University Brown University

EDITORIAL BOARD Frederick W. Alt (1993) Thomas D. Fox (1993) Alan Lambowitz (1993) Nadia Rosenthal (1995) Claudio Basilico (1994) Bruce Futcher (1995) Lester F. Lau (1995) Rodney Rothstein (1993) Susan Berget (1993) Michael Gilman (1995) Michael Lenardo (1994) Matthew P. Scott (1995) Alan Bernstein (1993) Stephen P. Goff (1995) Arthur D. Levinson (1993) Bart Sefton (1995) J. Michael Bishop (1993) Paula J. Grabowski (1994) David Levy (1995) Harinder Singh (1995) Elizabeth H. Blackburn (1994) Jack F. Greenblatt (1994) Susan Lindquist (1993) Stephen Smale (1994) Helen M. Blau (1994) Rudolf Grosschedl (1995) John T. Lis (1995) Frank Solomon (1994) Jef D. Boeke (1994) Mark Groudine (1993) James Manley (1995) Allan C. Spradling (1994) Marjorie C. Brandriss (1994) Christine Guthrie (1995) Kunihiro Matsumoto (1994) Karen U. Sprague (1995) Rodrigo Bravo (1995) James E. Haber (1993) Frank McCormick (1995) Nat L. Sternberg (1995) John B. E. Burch (1994) Joyce L. Hamlin (1993) N. Ronald Morris (1995) Tom H. Stevens (1995) Kathryn Calame (1994) Hidesaburo Hanafusa (1995) Bernardo Nadal-Ginard (1993) Bruce Stillman (1994) Judith Campbell (1995) Nathaniel Heintz (1994) Paul Neiman (1995) Kevin Struhl (1995) Mario R. Capecchi (1993) Ari Helenius (1993) Joseph R. Nevins (1993) Bill Sugden (1994) John A. Carbon (1993) Steven Henikoff (1994) Carol Newlon (1994) Kelly G. Tatchell (1995) Marian Carlson (1995) Ira Herskowitz (1993) Eric N. Olson (1995) Lawrence H. Thompson (1994) Nam-Hai Chua (1994) Alan Hinnebusch (1994) Harvey L. Ozer (1994) Lex H. T. van der Ploeg (1994) Jonathan A. Cooper (1995) Peter M. Howley (1994) Mary Lou Pardue (1994) Geoffrey Wahl (1995) Gerald R. Crabtree (1993) Stephen H. Hughes (1995) David Patterson (1994) Randolph Wall (1995) Elizabeth A. Craig (1994) James N. Ihle (1995) Marvin R. Paule (1993) Peter Walter (1993) Thomas Curran (1994) Mark Johnston (1994) Tony Pawson (1994) Jean Y. J. Wang (1993) Melvin L. DePamphilis (1995) Katherine A. Jones (1995) Scott Powers (1994) Lewis T. Williams (1994) Thomas Donahue (1995) James T. Kadonaga (1995) John R. Pringle (1994) Fred Winston (1994) Daniel J. Donoghue (1993) Michael Karin (1994) Randall R. Reed (1995) Richard Young (1995) Robert N. Eisenman (1994) Randall Kaufman (1994) Robin Reed (1993) Virginia A. Zakian (1995) Sarah C. R. Elgin (1994) Jack D. Keene (1993) Steven I. Reed (1994) Richard S. Zitomer (1994) Scott Emr (1994) Daniel Klessig (1995) Danny Reinberg (1994) Douglas Engel (1995) Monty Krieger (1995) Jasper D. Rine (1994) Stanley Fields (1994) Elizabeth Lacy (1993) Naomi E. Rosenberg (1994)

Barbara H. Iglewski, Chairman, Publications Board Linda M. Illig, Director, Journals Kenneth April, Production Editor Thomas R. May, Assistant Production Editor

Molecular and Cellular Biology, a publication of the American Society for Microbiology (ASM), 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171, is devoted to the advancement and dissemination of fundamental knowledge concerning the molecular biology of eucaryotic cells, of both microbial and higher organisms. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Journals Division. The journal is published monthly, one volume per year. The nonmember print subscription prices are $361 (U.S.) (Canadians add 7% GST) and $462 (other countries) per year; single copies are $40 (Canadians add 7% GST). The member print subscription prices are $80 (U.S.) (Canadians add 7% GST) and $105 (other countries); single copies are $10 (Canadians add 7% GST). For prices of CD-ROM versions, contact the Subscriptions Unit, ASM. Correspondence relating to subscriptions, defective copies, missing issues, and availability of back issues should be directed to the Subscriptions Unit, ASM; correspondence relating to reprint orders should be directed to the Reprint Order Unit, ASM; and correspondence relating to disposition of submitted manuscripts, proofs, and general editorial matters should be directed to the Journals Division, American Society for Microbiology, 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171. Phone: (202) 737-3600. Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20005, and at additional mailing offices. POSTMASTER: Send address changes to Molecular and Cellular Biology, ASM, 1325 Massachusetts Ave., N.W., Washington, DC 20005-4171. Made in the United States of America. Printed on acid-free paper. Copyright © 1993, American Society for Microbiology. All Rights Reserved. ISSN 0270-7306 CODEN: MCEBD4 The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center Inc., 27 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. ASM I Style Manual forJournals andBooks T his newly revised and updated edition will assist every author who submits papers to ASM. Prepared by ASM's profes- sional editorial staff specifically for the ASM journals and books, the manual incor- porates all of the information you need to ensure stylistically and grammatically correct manuscripts. The new edition includes two new chap- ters, "Proofreading" and "Books." In addition, it features in-depth instructions for assembling and editing the new Refer- ences section, which recently replaced the Literature Cited section in ASM journal articles. CONTENTS 1. Preparation of Manuscripts; 2. Numbers and Measurements; 3. Scientific Nomenclature; 4. English; 5. Sources for Materials; 6. Abbrevia- For more information, complete the coupon below and tions; 7. References; 8. Illustrations; 9. Tables; mail to: 10. Proofreading; 11. Books; 12. Words, Abbrevia- Chairmnan, Membership Committee American Society for Microbiology tions, and Designations; Appendix A. Journal 1325 Massachusetts Avenue, N.W. Washington, DC 200054171 Specifications; Appendix B. Production Cycle; Bibliography; Index I'm interested in membership in the American Society for Publication date: June 1991. Softcover, 188 pages Microbiology. Please send information and a Membership plus index, illustrated, Members, $23.00; nonmem- Application to: bers, $28.00. Canadian residents add 7% to cover the Name GST. Address Send order to ASM Press, P.O. Box 605, Herndon, VA 22070. City Journals Division State Zip Code -S B * American Society for Microbiology Country Student: [l Yes El No Date Author Index

Abeliovich, Hagai, 7766 Eisenman, Robert N., 7540 Kokubo, Tetsuro, 7859 Oleksa, Lisa M., 7288 Adams, Roger L. P., 7372 Ellison, Eldora L., 7531 Kornberg, Thomas B., 7961 Oliff, Allen, 7802 Altiok, Soner, 7303 Erhardt, Peter, 7645 Krueger, James G., 7507 Oren, Moshe, 7942 Arai, Ken-ichi, 7399 Krystal, Gerald, 7577 Arai, Naoko, 7399 Fajardo, J. Eduardo, 7295 Kubrich, Michael, 7364 Papageorge, Alex G., 7718 Ariga, Hiroyoshi, 7747 Fattaey, Ali R., 7267 Kuff, Edward L., 7439 Parsons, J. Thomas, 7892 Attisano, Liliana, 7239 Fewell, Joseph W., 7439 Paterson, Hugh F., 7612 Finbloom, David S., 7515 Lake, Robert J., 7793 Pesce, Susan, 7874 Bailly, Manuella, 7257 Flynn, Daniel C., 7892 Lakhe-Reddy, Sujata, 7288 Petzold, Audrey S., 7864 Ballard, Dean W., 7826 Fujita, Donald J., 7408 Larner, Andrew C., 7515 Pfahl, Magnus, 7698 Banker, Deborah E., 7540 Lauderdale, James D., 7596 Pfanner, Nikolaus, 7364 Baron, Margaret H., 7457 Galasso, Debora L., 7587 Lazaris-Karatzas, Anthoula, Plaza, Serge, 7257 Behringer, Richard R., 7666 Ganchi, Parham A., 7826 7358 Plowe, Christopher V., 7349 Benezra, Robert, 7874 Geiser, John R., 7913 Lee, Jeng-Shin, 7487 Pouwels, Karin, 7774 Bergot, Marie-Odile, 7725 Goddard, John P., 7372 Lee, Mi-Ock, 7698 Prakash, Louise, 7757 Bibbins, Kirsten B., 7278 Gong, Da-Wei, 7859 Lees, Jacqueline A., 7813 Prakash, Satya, 7757 Birge, Raymond B., 7295 Goodhart, Paula J., 7802 Lehmann, Jurgen M., 7698 Prasad, K. V. S., 7708 Blom, Jolanda, 7364 Goodwin, Graham H., 7612 Lepage, Pierre, 7380 Boeuf, Helene, 7278 Gralla, Jay D., 7469 Lessnick, Stephen L., 7393 Quatannens, Brigitte, 7257 Bogenmann, E., 7447 Graupner, Gerhart, 7698 Leu, Tzeng-Horng, 7892 Bornws, Claus, 7604 Greene, Warner C., 7826 Levy, Naomi, 7942 Rapp, Ulf R., 7645 Bos, Johannes L., 7248 Grimley, Philip M., 7515 Lewis, Brian C., 7393 Rapp, William D., 7232 Bottorff, Drell, 7311 Groner, Bernd, 7303 Li, Qiliang, 7636 Rassow, Joachim, 7364 Braun, Benjamin S., 7393 Gros, Philippe, 7380 Li, Wen-Zhuo, 7836 Rathjen, Peter D., 7971 Breunig, Karin D., 7566 Guerra, Maria-Jos6 M. Diaz, Liang, T. Jake, 7476 Raymondjean, Michel, 7725 Brewer, Gary, 7652 7725 Lipsick, Joseph S., 7334 Repke, Heinrich, 7708 Brinster, Ralph L., 7666 Guha, Abhijit, 7203 Liu, Keyi, 7596 Reynolds, Albert B., 7892 Brown, Susan S., 7864 Guo, Zijian, 7836 Liu, Vivian F., 7222 Riggs, Karen J., 7487 Burgering, Boudewijn M. T., Lobanenkov, Victor V., 7612 Ripmaster, Tracy L., 7901 7248 Haarer, Brian K., 7864 Long, Laura, 7652 Roeder, Robert G., 7859 Cadd, Gary G., 7666 Hair, Alan, 7925 Look, Thomas, 7813 Rosenwald, Igor B., 7358 Cai, Hong, 7645 Hanafusa, Hidesaburo, 7295, Lowenberg, Bob, 7774 Rudd, Christopher E., 7708 Calame, Kathryn, 7487 7507 Lowy, Douglas R., 7718 Russo, Patrick, 7836 Cantley, Lewis C., 7708 Harlow, Ed, 7267, 7813 Lueders, Kira K., 7439 Heath, Carol M., 7612 Lunkes, Astrid, 7566 Saito, Midori, 7813 Carne, Alexander F., 7612 Saleque, Shireen, 7487 Carriere, Catherine, 7257 Heimbrook, David C., 7802 Lunsford, Lynn B., 7393 Helin, Kristian, 7267, 7813 Lupold, D. Shelley, 7232 Samson, Leona, 7213 Cato, Andrew C. B., 7850 Saule, Simon, 7257 Cen, 7718 Hermann, Thomas, 7698 Hui, Hoefsloot, Lies H., 7774 Maarse, Ammy C., 7364 Schaefer, Andrew W., 7652 Chang, Bill H., 7913 Schedl, Paul, 7522, 7734 7469 Hoffmann, Birgit, 7698 Mack, Susan, 7232 Chang, Chenbei, Holmberg, Steen, 7604 Mao, Xianzhi, 7496 Schjerling, Peter, 7604 Chen, Beiru, 7213 Schlessinger, J., 7677 Alice Horabin, Jamila I., 7734 Martin, Patrick, 7257 Churchill, C. L., 7782 Horikoshi, Masami, 7859 Martinez, Antoine, 7725 Schmidt, Emmett V., 7358 Clayton, David A., 7935 Schmitt, Mark E., 7935 7311 Hromas, Robert, 7393 Martinez, Diane, 7288 Colleton, Michael, Hu, P., 7677 Massague, Joan, 7239 Schuler, Mary A., 7689 Conroy, Robert, 7802 Shamah, Steven M., 7203 7645 Huang, Jiakang, 7476 Masuda, Esteban S., 7399 Cooper, Geoffrey M., Huber, Hans E., 7802 Matsushima, H., 7447 Sharp, Phillip A., 7953 Cowan, Nicholas J., 7625 Sherman, Fred, 7836 7652 Hung, Peggy, 7399 May, William A., 7393 Crater, Dinene, McCullough, Andrew J., 7689 Shi, Yang, 7487 Crimmins, Dan L., 7418 Ignjatovic, Mette W., 7604 Shibahara, Shigeki, 7881 7725 McKnight, G. Stanley, 7666 Cuif, Marie-Helene, Ihle, James N., 7577 McWhirter, John R., 7587 Shlomai, Joseph, 7399, 7766 Darby, Martyn K., 7496 Ivey-Hoyle, Mona, 7802 Medema, Rene H., 7248 Singer, Richard A., 7553 David, Michael, 7515 Meijer, Michiel, 7364 Singh, Keshav K., 7213 Davis, Trisha N., 7913 Jacobs, Yakop, 7321 Merrell, Kevin T., 7487 Sithanandam, Gunamani, 7645 DeHaven, Kristin, 7652 Janssen, Ottmar, 7708 Meyers, Rachel E., 7953 Skolnik, E. Y., 7677 Dekker, Peter J. T., 7364 Jelinek, Warren R., 7793 Miralpeix, Montserrat, 7418 Smith, Austin G., 7971 DeMaria, Christine T., 7652 Johnston, Gerald C., 7553 Mondino, A., 7677 Soeller, Walter C., 7961 Denninger, Anne, 7850 Josephson, Betty, 7636 Morgan, Garry T., 7925 Sonenberg, Nahum, 7358 Denny, Christopher T., 7393 Morozov, Viktor E., 7439 Stamatoyannopoulos, George, Devault, Alain, 7380 Kahn, Axel, 7725 Morrisey, Joanne, 7349 7636 de Vries-Smits, Alida M. M., Kapeller, Rosana, 7708 Moscat, Jorge, 7645 Stehelin, Dominique, 7257 7248 Kaslow, David C., 7349 Mui, Alice L.-F., 7577 Stein, Arnold, 7596 Diaz-Meco, Maria T., 7645 Kaspar, Felizia, 7850 Muller, Eric G. D., 7913 Stern, David B., 7232 Dini, Peter W., 7334 Kass, Stefan U., 7372 Muraosa, Yasushi, 7881 Stiles, Charles D., 7203 Dong, Fan, 7774 Kazmierczak, Pam, 7782 Myers, Martin G., Jr., 7418 Stone, James C., 7311 Driscoll, Donna M., 7288 Kielland-Brandt, Morten C., Sudol, Marius, 7507 Duke-Cohan, Jonathan S., 7604 Nakatani, Yoshihiro, 7859 Sun, Shao-Cong, 7826 7708 Kihara-Negishi, Fumiko, 7747 Negishi, Yoichi, 7747 Sun, Xiao Jian, 7418 Duwel, Annette, 7971 Kim, Dae-Hyuk, 7782 Neiman, Paul E., 7612 Sundberg, Holly A., 7913 Dyer, Michael A., 7457 Kimchi, Adi, 7942 Nelson, Christian, 7321 Sung, Patrick, 7757 Dyson, Nicholas, 7813 Klemsz, Michael, 7393 Nicolas, Robert H., 7612 Klenova, Elena M., 7612 Takada, Ritsuko, 7859 Ehrenman, Karen, 7652 Klocker, Helmut, 7850 Oh, Charles Euk, 7961 Tertoolen, Leon G. J., 7248 i ii AUTHOR INDEX MOL. CELL. BIOL.

Theisen, Manfred, 7666 Van Alfen, Neal K., 7782 Walden, Paul D., 7625 Xu, Qunli, 7553 Tokumitsu, Hiroshi, 7399 van Buitenen, Carin, 7774 Wang, Jean Y. J., 7587 Touw, Ivo P., 7774 van Weeren, Pascale C., 7248 Watkins, John F., 7757 Yamashita, Shinya, 7859 Trepicchio, William L., 7457 Varmus, Harold E., 7278 Weaver, David T., 7222 Yi, Taolin, 7577 Troppmair, Jakob, 7645 Vass, William C., 7718 Wellems, Thomas E., 7349 Yonish-Rouach, Elisheva, Tsuboi, Akio, 7399 Vaughn, George P., 7901 White, Morris F., 7418 7942 Tsujita, Rumiko, 7747 Verma, Inder M., 7429 Whyatt, Linda M., 7971 Zachariae, Wolfgang, 7566 Tzfati, Yehuda, 7766 Vidal, Marc, 7813 Wieser, Rotraud, 7239 Zenke, Frank T., 7566 Vierra, Craig, 7321 Wisdom, Ron, 7429 Zhang, Jun-Wu, 7636 Udvardy, Andor, 7522 Vogel, Lee B., 7408 Wong, Kwok-kin, 7487 Zhang, Ke, 7718 Uyttendaele, Hendrik, 7507 Vogt, Volker M., 7531 Woolford, John L., Jr., 7901 Zhang, Lei, 7782 Voos, Wolfgang, 7364 Wrana, Jeffrey L., 7239 Zhang, Wei, 7652 Vaidya, Akhil B., 7349 Zhang, Xiao-kun, 7698 Valentine, Marcus, 7813 Wagner, Belinda J., 7652 Xiao, Wei, 7213 Zhao, Yuhang, 7507 1994 APPLICATION FOR STUDENT MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1325 Massachusetts Ave. NW * Washington, DC 20005-4171 - (202) 942-9319 * FAX (202) 942-9347 Eligibility Any matriculated student majoring in microbiology or a related field who has NOT earned a doctoral degree is eligible for election as a Student Member. Student Members have all the privileges of membership except the right to vote and hold office in the Society Student Members reserve ASM News monthly and are entitled to subscribe to the Society's scientific journals at member rates. Initiation Memberships are initiated and renewed in Januaryeach year. Unlesstherearedirectionstoth contrary, membership nominations received prior to September 1 are credited to the current year. Nominations received after September 1 will become effective the following January. NAME MS.miss (CIRCLE ONE) MRS. MR. FIRST INITIAL LAST MAIL NAME AS YOU WANT IT TO APPEAR ON YOUR MAILING LABEL ADDRESS WHERE YOU WANT TO RECEIVE YOUR SUBSCRIPTIONS

STATE/PROVINCE ZIP/POSTAL CODE COUNTRY PHONE ( ) FAX ( ) YEAR OF BIRTH SEX HIGHEST DEGREE MAJOR FIELD OF STUDY SCHOOL SIGNATURE OF APPLICANT DATE SIGNATURE OF CHAIRMAN OF MAJOR DEPARTMENT MEMBER #l l l *NOMINATED BY ______MEMBER #1 SIGNATURE OF ASM MEMBER 'if your departmental chairman is a member of the ASM, a nominating signature is not required If you are not associated with an ASM nominating member, you can still send in this member application form and we will contact you. Be sure to include your dues. Member How did yoU first learn about the ASM? (Check one): Information El A colleague O An ASM journal El Presenting a paper at an ASM meeting L A professor L An ASM Branch LI An advertisement in ASM journal L Direct mail inquiry Journals P/ease check: L Enclosed is my dues payment (U.S. Dollars only) ...... $15 El Please send me the following ASM journal(s) at Member Price(s): Print Canada Only Amount* Antimicrobial Agents & Chemotherapy ...... $52 AA Applied & Environmental Microbiology ...... $53 AE Molecular & Cellular Biology ...... $86 CB Clinical Microbiology Reviews ...... $21 CM Infection & Immunity ...... $55 IA Int'l Journal of Systematic Bact...... $37 IJ Journal of Bacteriology ...... $85 JB Journal of Clinical Microbiology ...... $52 JC Journal of Virology ...... $87 JV Microbiological Reviews ...... $27 MR Clinical & Diagnostic Laboratory Immunology ...... $43 -LI ASM News ...... $0 Total Journal Fees $ *7% GST has been included in the subscription price Add your $15 Membership Dues +15 Total $

PAYMENT IN U.S. DOLLARS MUST ACCOMPANY APPLICATION A membership card, division registration form, and the journal(s) of your choice will be sent within 90 days upon completion of processing. ASM dues are tax deductible to the extent permitted by law. ASM designates $12 of your dues for ASM News. Rates are for 1994 only. Applicants must remit in U.S. Dollars by check or draft payable to ASM through a U.S. bank located within the Continental U.S. Applicants from Canada may use check made out in U.S. Dollars and drawn on a Canadian bank or applicants may choose to pay with VISA, MasterCard, Eurocard, or American Express. If that is your preference, please fill in the box below. [I VISA # I I I I IEXPIRATION |] MASTERCARD # DATE: .AMEX # MO YR EUROCARD #SIGNATURE______TODAY'S DATE A NAME AS IT APPEARS ON YOUR CREDIT CARD MONTH DAY Y AR IL ^ 1293 SIGNATURE. 1994 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1325 Massachusetts Ave. NW - Washington, DC 20005-4171 * (202) 942-9319 * FAX (202) 942-9347 Eligibility ASM vwelcomes to full membership anyone who is interested in its objectives and has a minimum of a bachelor's degree or equivalent in microbiology or a related field. Initiation Memberships are initiated and renewed in Januaryeach year. Uniesstherearedirectionstothecontrary, membership nominations received priorto September 1 are credited tothe current year. Nominations received after September 1 will become effective the following January. NAME MS.MISS DR.II (CIRCLE ONE) MRS. MR. FIRST INITIAL LAST MAIL NAME AS YOU WANT IT TO APPEAR ON YOUR MAILING LABEL ADDRESS WHERE YOU WANT TO RECEIVE YOUR SUBSCRIPTIONS

STATE/PROVINCE ZIP/POSTAL CODE COUNTRY PHONE ( ) FAX ( ) YEAR OF BIRTH SEX HIGHEST DEGREE SUBJECT AREA YEAR EARNED_ EMPLOYER PRESENT POSITION SIGNATURE OF APPLICANT DATE *NOMINATED BY ______MEMBER #l It I SIGNATURE OF ASM MEMBER *If you are not associated with an ASM nominating member, you can still apply for membership and we will contact you if there is a problem Member How did you first learn about the ASM? (Check one): Information D A colleague L An ASM journal E An ASM Branch D Direct mail inquiry D A professor [ A workshop, conference or meeting Ol An advertisement in ASM journal Dues Annual dues for 1994 are $75. Dues include ASM News (monthly) and a $51 credit which may be deducted from the total cost of the journal(s) you purchase at the special membership rates indicated below. Journals o Enclosed is my dues payment (U.S. Dollars only) $75 O Please send me the following ASM journal(s) at Member Price(s): select: DOS MAC Canada Print CD-ROM Print & A * For CD-ROM O El Only Only CD-ROM Amount* Antimicrobial Agents & Chemotherapy ...... $52 .$162 . $186 AA Applied & Environmental Microbiology ...... $53 .$163 . $187 AE Molecular & Cellular Biology $86 .$166 . $214 CB Clinical Microbiology Reviews ...... $21. $80.$91 CM Infection & Immunity ...... $55 .$164 . $188 IA Int'l Journal of Systematic Bact ...... $37. $81 .$102 IJ Journal of Bacteriology ...... $85 . $165.. $213 JB Journal of Clinical Microbiology ...... $52 .$160 . $186 JC Journal of Virology ...... $87 .$167 . $215 JV Microbiological Reviews ...... $27 .$84 . $94 _ MR Clinical & Diagnostic Laboratory Immunology ...... 3...... $128 ..$144_....LI ASM News ...... $0 .N/A ..N/AN __ Total Journal Fees $ *7% GST has been included in the subscription price Subtract your $51 Member Journals Credit - $51 Subtotal (if less than zero, enter zero) $ Add your $75 Membership Dues + 75 Total (Dues plus Journals). If total is less than $75.00, enter $75 $ PAYMENT IN U.S. DOLLARS MUST ACCOMPANY APPLICATION A membership card, voting division form, ASM Placement Service Information and the journal(s) of your choice will be sent within 90 days upon completion of processing. ASM dues are tax deductible to the extent permitted by law. ASM designates $13 of your dues for ASM News. Rates are for 1994 only. Applicants must remit in U.S. Dollars by check or draft payable to ASM through a U.S. bank located within the Continental U.S. Applicants from Canada may use check made out in U.S. Dollars and drawn on a Canadian bank or applicants may choose to pay with VISA, MasterCard, Eurocard, or American Express. If that is your preference, please fill in the box below.

VISA # El II II IEXPIRATION O MASTERCARD # DATE:L lDAMEX# MO YR LI EUROCARD# NAME TODAY'S DATE INAME AS IT APPEARS ON YOUR CREDIT CARD MONTH DAY YEAR MCB 12/93 |SIGNATURE_ ____ Statement of Ownership, Management and Circulation (Required by 39 U.S. C. 3685)

11A. Title of Publication PUBLICATION NO. 2. Date of Filing

;4olecular and Cellular Biology 2 7 7 3 6 10-12-93 3. Freauency of Issue 3A. No. of Issues Published 3B. Annual Subscription Price Annually Monthly 12 A80 mbr, $361 nonmbr 4. Complete Mailing Address of Known Office of Publication (Street, City. CGea, State on ZJP+4 Con) (Not printers) American Society for Microbiology 1325 Massachusetts Ave., N.W., llashinnoton, D.C. 20005-4171 S. Complete Mailing Address of the Headquarters of_ishefGeneral Business Offices of the (No priner) (Same as above)

6. Full Names and Complete Mailing Address of Publisher, Editor, and Managin Editor (Fs km MUST NOT b. blak) Publisher (Naste and Complete Mailing Address)

(Same as above) Editor (Name ond Complete Mailing Address) Alan M. Weiner (Address same as above) Managing Editor (Name and Complete Mailing Address) Linda M. Illig (Address same as above)

7. Owner (If twned bv a corporation, its name and ddress mutt be stated and also iwedately therender the names and addresses of stockholders owning or holding percent or more of total amount of stork. If not owned by a corporation, the ass _n ddresses of the inditidual owners must be gisen. If osned bv a partnership or other unincorporated trm. its name and address, as well as that of each idtAvl sm be givex. If the publication is published bv a nonprofit organizatirtn. its name and address must be stated.) (hem must be completed.) Full Ne Compbte Meling Address American Society for Microbiology 1325Thsacustts Ave..N.W______Washinnton. D.C- 20005-4171

I.

8. Known Bondholders. Mortgagees, and Other Security Holders Owning or Holding 1 Percent or More of Total Amount of Bondst Mortgages or Other Securities (If there are one. so state) Full Name Compbte Maling Address None i

9. For Completion by Nonprofit Organizations Authorized To Mail at Special Rates (DOM Serlon 424.12 only) The purpose, function, and nonprofit status of this organization and the exempt status for Federal income tax purposes (Check ote) 111 12) I Has Not Changed During Has Changed During (ifchanged. publisher must submit explanation of Preceding 12 Months Li Preceding 12 Months change with this statement.) 10. Extent and Nature of Circulation Average No. Copies Each Issue During Actual No. Copies of Single Issue (See instructions on reverse side) Preceding 12 Months Published Nearest to Filing Date A. Total No. Copies (Net Press Run) 7 ,075 7 ,100 Be, Paid snd/or Requested Circulation 1. Sales through dealers and carriers, street vendors and counter sales 2. Mail Subscription (Paid and/or requested) 5,438 5,955 C. Total Paid and/or Requested Circulation (Sum of 1061 and 1062) 5,438 5,955 D. Free Distribution by Mail, Carrier or Other Means Samples. Complirnentary, and Other Free Copies 47 47 E. Total Distribution (Sum of Cand D) 5,485 6,002 F. Copies Not Distributed 1. Office ttse. left over, unaccounted, spoiled after printing 1,590 1,nq8 2. Return from News Agents

G. TOTAL (Sum of E. Fl and 2-should equal net press run shouw in A) 7,075 7,100 11. Signature and Title of Editor. Publisher. Business Manager, or Owner I certify that the statements made by ,l - & me above are correct and complete A 7 Director, Journals PS Form 3526. Ianuarv 1991 (See insJt7Seions one reverse) AUTHOR INDEX VOLUME 13

Aaronson, Stuart A., 762 Asuru, Agatha I., 1920 Beg, Amer A., 3301, 6089 Bommakanti, Madhavi, 1796 Abate, Cory, 2354 Atchison, Michael L., 6621 Behn, Christian, 3002 Bonagura, Christopher A., Abdollahi, Abbas, 841 Atherton-Fessler, Sue, 1675 Behrens, Sven-Erik, 307 1332 Abeliovich, Hagai, 7766 Attisano, Liliana, 7239 Behringer, Richard R., 7666 Bond, Vincent C., 3221 Abelson, John, 1876, 2959 Au-Fliegner, Macy, 5725 Beland, Janice L., 4459 Bongarzone, I., 358 Abisdris, Gil, 4703 Auger, Kurt R., 1657 Belanger, Luc, 1619 Bonner, William M., 984 Adams, Roger L. P., 7372 Auron, Philip E., 1332, 2929 Belasco, Joel G., 5034 Bonventre, Joseph V., 1933 Adler, Adam J., 6326 Austin, Richard J., 2742 Belhumeur, Pierre, 2152, 2846 Borgman, Cheryl A., 785 Aebersold, Ruedi, 5771 Avanzi, Giancarlo, 4976 Bell, Sheila M., 5888 Bornms, Claus, 7604 Agabian, Nina, 144 Axelos, Michele, 2614 Benchimol, Sam, 1456 Borrello, M. G., 358 Agapite, Julie, 5981 Ayusawa, Dai, 6036 Bender, Timothy M., 2858 B6rsch, Dagmar, 1708 Agranoff, Adam B., 6283 Aziz, Natasha, 3505 Bender, Timothy P., 3505 Bos, Johannes L., 155, 7248 Ahn, Natalie G., 2546 Aziz, Nazneen, 1847 Benech, Philippe D., 2182 Boschelli, Frank, 5112 Aigle, Michel, 5070 Benezra, Robert, 7874 Bose, Henry R., Jr., 6147 Akeson, Richard, 3002 Baccarini, Manuela, 3245 Bennett, J. Lindsley, 7036 Bottorff, Drell, 7311 Akira, Shizuo, 1854 Bacchetti, Silvia, 6064 Ben-Or, Sarah, 331 Boubnov, Nikolai V., 6957 Al-Alawi, Nadia, 2497 Backer, Jonathan M., 6653 Ben-Shushan, Etti, 891 Bours, Vincent, 6157 Alberts, Arthur S., 2104 Baekkeskov, Steinunn, 4223 Bensi, Giuliano, 6231 Bouton, Amy H., 2391 Alcami, Jos6, 4770 Baer, Richard, 801 Benz, Christopher C., 2247 Bowdish, Katherine S., 2172 Aldrich, Teri L., 3424, 3434 Bagchi, Srilata, 6537 Berger, Shelley, 5981 Brabletz, Thomas, 1155 Aldridge, Claire, 3929 Bagrodia, Shubha, 1464 Berget, Susan M., 2677 Brach, Marion A., 4284 Allard, Denis, 1619 Bai, Guang, 993 Berghard, Anna, 677 Bradshaw-Rouse, Judith, 6274 Allis, C. David, 163 Bailey, C. S., 6044 Bergman, Mathias, 5290 Bram, Richard J., 4760 Allison, Lizabeth A., 6819 Bailly, Manuella, 7257 Bergman, Yehudit, 891 Brambilla, Paolo, 5122 Alt, Frederick W., 5216, 6223 Bain, Gretchen, 3522 Bergot, Marie-Odile, 7725 Branciforte, Dan, 5383 Altan, Nihal, 5549 Baker, Bruce S., 174 Bergsma, Derk J., 6012 Brancolini, Claudio, 4976 Altiok, Soner, 7303 Baker, Henry V., 543 Berk, Arnold J., 1232, 3291 Brandt, Cameron S., 5348 Altmann, Michael, 4860 Balasubramanian, Bhuvana, Bernier, Daniel, 1619 Branton, Philip E., 7112 Alvira, Mauricio, 578 6071 Bernier, Michel, 4736 Braun, Benjamin S., 7393 Alwine, James C., 961 Balderes, Dina, 1306 Bernstein, Kenneth E., 18 Bravo, Rodrigo, 1572, 1911, Amacher, Sharon L., 1779, Baldwin, Albert S., Jr., 1315, Berra, Edurne, 4770 2020, 5195 2753 3301, 3964, 6089, 7191 Bertrand, Helmut, 6778 Brayton, Kelly A., 4784 Amero, Sally A., 5323 Baler, R., 1599 Bethlendy, Gabor, 6442 Brazas, Robert M., 5524 Amin, Chirag, 383 Baler, Ruben, 2486 Beyer, Ann L., 5323 Breathnach, Richard, 5461 Ammerer, Gustav, 2069 Bales, K. R., 6044 Bhat, Narayan K., 6201 Breeden, Linda, 1069, 3792 Amstad, Paul, 6992 Ballard, Dean W., 7826 Bhatia, Kishor, 3557 Breitman, Martin L., 4400 An, Jiabin, 6157 Ballester, Roymarie, 487 Bibbins, Kirsten B., 7278 Bremner, Rod, 4588 Ananthan, J., 1599 Balogh, Robert, 18 Bieker, James J., 2776 Brenner, Barry M., 1847 Andersen, Lone B., 487 Baltimore, David, 351, 1547, Biggin, Mark D., 2742 Brennwald, Patrick, 1353 Anderson, Gregory J., 4342 3557, 3698, 5679, 5957 Bilyeu, Timothy, 4233 Brents, Leslie A., 3505 Anderson, James T., 2730, Baltz, T., 1146 Bird, Timothy A., 2384 Breunig, Karin D., 7566 6102 Banerjee-Basu, Sharmila, 7019 Birge, Raymond B., 4648, Breunig, K. D., 3058 Anderson, Philip, 902 Banker, Deborah E., 7540 7295 Brewer, Gary, 7652 Anderson, Stephen, 1471 Banno, Hiroharu, 4745 Birnbaum, Morris J., 6653 Brewer, Joseph W., 3929 Andersson, Maria, 4066 Barbacid, Mariano, 5500 Birshtein, Barbara K., 3611 Brickner, Howard, 5450 Andres, Vicente, 2564 Barbas, Julio A., 1433 Bishop, J. Michael, 6241 Brierley, Ian, 6931 Andrews, David W., 4703 Bardelli, Alberto, 4600 Bishop, Richard W., 2706 Brigati, Claudio, 1306 Andrews, Lucy G., 3494 Barnea, G., 1497 Bishop, Terry R., 2929 Brindle, Paul, 4852 Andrews, Matthew T., 4776 Barnett, Thomas R., 1273 Black, Elizabeth, 5370 Bringaud, F., 1146 Andrews, Nancy C., 5604 Baron, Margaret H., 7457 Blackburn, Elizabeth H., 6586 Brinster, Ralph L., 320, 5266, Aoyama, Akira, 1824 Barrett, John F., 1130 Blacketer, Melissa J., 5567 7666 Arai, Ken-ichi, 1440, 7399 Bartholomew, Blaine, 942 Blackwell, Catherine, 2952 Broek, Daniel, 1345 Arai, Naoko, 7399 Bartkowski, Sigrid, 421, 6416 Blackwell, T. Keith, 5216 Bronson, Roderick, 1998 Arai, Yuji, 6469 Bartlett, John D., 4736 Blais, Yves, 2846 Brow, David A., 3015 Araki, Hiroyuki, 3067, 3076 Bartunek, Petr, 3675 Blake, Christa M., 3266 Brown, Anne B., 4432 Arceci, Robert J., 2235 Basi, Gabriele, 5122 Blanc, Antony, 4860 Brown, Doris R., 6849 Arenzana-Seisdedos, Basilico, Claudio, 1998, 3202 Blanco, Jorge C. G., 6157 Brown, Fred L., 5245 Fernando, 1290, 4770 Bastiani, Carol, 2298 Blaquiere, Martin, 1619 Brown, Jeffrey L., 6346 Argentin, Stefania, 600 Bauer, Florian, 5070 Blechman, Janna, 2224 Brown, Kenneth D., 4928 Ariga, Hiroyoshi, 7747 Bauer, Reinhard, 4174 Blenis, John, 6260 Brown, Susan S., 7864 Arighi, E., 358 Baumann, Heinz, 2384 Blom, Jolanda, 7364 Broz, Susan D., 2666 Ariizumi, Kiyoshi, 5629 Baxter, John D., 3042 Bloom, Kerry, 3156 Brudnak, Mark, 928 Armstrong, Robert, 4852 Bazenet, Chantal, 133 Bocco, Jos6 Luis, 561 Brugge, Joan S., 1863 Aroian, Raffi V., 626 Beachy, Philip A., 6941 Bodley, Annette L., 6190 Bruhn, Kevin, 2536 Arroyo, May, 6537 Beall, Clifford J., 4549 Boeuf, Helene, 7278 Bruhn, Laurakay, 6866 Asakura, Atsushi, 7153 Bear, Susan E., 1759 Bogenhagen, Daniel F., 5149 Brunel, Claude, 1641 Ash, John, 1565 Beauchemin, Michel, 1619 Bogenmann, E., 7447 Bucheton, Alain, 1042 Asiedu, Clement K., 6810 Beccari, Elena, 6479 Boguski, Mark, 1345 Buckler, Charles, 2193 Askew, G. Roger, 4115 Beckendorf, Steven K., 184 Boise, Lawrence H., 1911 Buday, Laszl6, 1903 Asselin, Myriam, 4904 Becker, Kevin G., 6157, 6629 Boissonneault, G., 4323 Budd, Martin E., 496 Assoian, Richard K., 3588 Beebe, David C., 3282 Bolger, Graeme, 6558 Bueno, Avelino, 2286 i ii AUTHOR INDEX MOL. CELL. BIOL.

Buettner, Reinhard, 4174 Cauthron, Robert D., 2332 Cismowski, Mary J., 3744 Daar, Ira O., 7170 Bullock, Peter A., 2882 Cecefia, Grace, 2214, 6742 Clark, Edward P., 4416 D'Addario, Mario, 6231 Buonanno, Andres, 7019 Cech, Thomas R., 4301 Clark, Edwin A., 1863 Daegelen, Dominique, 9 Burden, Steven J., 5133 Cegielska, Aleksandra, 1202 Clark, Karen L., 1 Dahl, Gerhard, 2486 Burgering, Boudewijn M. T., Cen, Hui, 7718 Clark, Marcus R., 5877 Dahlman-Wright, Karin, 399 7248 Cepko, Constance L., 2604 Clark, Melody E., 1232 Dahlseid, Jeffrey N., 3598 Burton, Janet, 5829 Cerutti, Peter, 6992 Clark, Michael W., 2152, 2441 Dailey, Harry A., 7122 Buschmann, Jan, 276 Cha, Ying, 690 Clark, Robin, 2497, 6615 Dalmon, Jacques, 1183 Bushman, Janet L., 1920, Chae, Chi-Bom, 5538 Clarke, Louise, 4578 Daly, Christopher, 3756 4618 Chakrabarti, Ranjan, 6052 Clarke, Michael F., 711 Dancis, Andrew, 4342 Buskin, Jean N., 2753 Chambers, Ian, 6290 Clay, William C., 6678 D'Andrea, Alan D., 739, 2929 Bussey, Howard, 4039, 6346 Chambon, Pierre, 462 Clayton, David A., 1951, 7935 Danese, Paul N., 6304 Busslinger, Meinrad, 4657, Champion-Arnaud, Patrick, Cleghon, Vaughn, 2203 Dang, Chi V., 1130 6024 5461 Clemens, Michael, 6897 Daniel, Janice, 2247 Bustelo, Xose R., 5500 Chan, Andrew M.-L., 762 Cleveland, John L., 1788 Danish, Rizwan, 711 Butler, Braeden, 1034 Chandra, Gyan, 6678 Coats, Sarah G., 5567 Danthinne, Xavier, 3340 Byrne, Carolyn, 3176 Chang, Bill H., 7913 Cobb, Melanie H., 801 Danzeiser, Deborah A., 4670 Chang, Chenbei, 7469 Coffino, Philip, 2377 Darby, Martyn K., 7496 Cadd, Gary G., 7666 Chang, Eric, 487 Coggeshall, K. Mark, 5877 D'Arcangelo, Gabriella, 3146 Cade, Rebecca, 2069 Chang, Wen-teh, 3632 Cogswell, John P., 2858 Darlington, Gretchen J., 4233 Cafferkey, Robert, 6012 Chao, Yesu, 934 Cogswell, Patricia C., 2858, Darnell, James E., Jr., 3951 Cai, H., 39 Charest, David L., 4679 3964 Dasgupta, Asim, 1232 Cai, Hong, 7645 Chasin, Lawrence A., 289, Cohen, Bruce D., 6462 Datar, Kshama V., 2730 Calame, Kathryn, 7487 5085, 6211 Cohen, Justus B., 2666 Datta, Bansidhar, 5377 Calos, Michele P., 2688 Chatton, Bruno, 561 Coleman, Timothy A., 3802, Davey, John, 80 Calothy, Georges, 3401 Chaudhuri, M., 1449 3850 David, E., 6375 Cambier, John C., 5877 Chedid, Marcio, 762 Colleton, Michael, 7311 David, Michael, 1634, 3984, Camier, Sylvie, 4391 Chen, Beiru, 7213 Collins, Francis S., 487 7515 Camilloni, Giorgio, 6702 Chen, Benjamin P. C., 7180 Collins, Tucker, 6283 Davidson, Irwin, 961 Camonis, Jacques, 487, 2815 Chen, Dan, 228 Comoglio, Paolo M., 4600 Davidson, Wendy F., 2578 Campbell, David A., 207 Chen, Ding-Shinn, 432 Concordet, Jean-Paul, 9 Davis, Roger J., 4125 Campbell, Judith L., 496 Chen, Hongwu, 2366, 5970 Conklin, Douglas S., 2041 Davis, Trisha N., 1779, 7913 Candido, E. Peter M., 1371 Chen, Huei-Mei, 6766 Connelly, Sheila, 6403 Dean, Ann, 911 Canoll, P. D., 1497 Chen, I-Tsuen, 289 Connolly, Denise C., 5888 DeAngelo, Daniel J., 1746 Cantley, Lewis, 6052 Chen, Jiandong, 3255, 4107 Conroy, Robert, 7802 Deb, Sumitra, 6849 Cantley, Lewis C., 1657, Chen, Jianzhu, 6223 Coon, Michael E., 7056 Deb, Swati Palit, 6849 4648, 7708 Chen, Jing X., 1440 Cooper, G., 39 DeCaprio, James A., 367, Capecchi, Mario R., 2134 Chen, Lihong, 5195 Cooper, Geoffrey M., 7645 3975 Caponigro, Giordano, 5141 Chen, Lihua, 4814 Cooper, J., 6889 Decker, Thomas, 3245 Capra, J. Donald, 5593 Chen, Min, 443 Cooper, Jonathan A., 1737, DeClue, Jeffrey E., 6799 Carayannopoulos, Leon, 5593 Chen, Rey-Huei, 6260 2546 de Crombrugghe, Benoit, 4505 Carbon, John, 4884 Chen, Rui-hong, 4423 Cooper, Terrance G., 5749 Deeley, Roger G., 4186 Carcano, C., 358 Chen, Shiming, 831 Cooper, Thomas A., 3660 DeFalco, Jeffery, 1746 Cardillo, Thomas S., 6442 Chen, Xin Jie, 3882 Copeland, Neal G., 3722 Deffie, Abdul, 3415 Cardoso, M. Cristina, 2564 Chen, Yan, 4214 Copeland, William C., 809 DeFranco, Anthony L., 5679 Carey, Michael, 7045 Cheney, Clarissa M., 217 Corley, Ronald B., 3929 Degen, Jay L., 5888 Carles, Christophe, 114 Cheng, Jiin-Tsuey, 801 Comelissen, Marc, 3340 Degtyareva, Natasha P., 5315 Carlson, Marian, 3872 Cheng, Jiu, 1892, 3359 Corvera, Silvia, 6052 DeHaven, Kristin, 7652 Carlson, Sara G., 4736 Cheng, Soo-Chen, 1876, 1883 Costanzo, Maria C., 4806 Deisseroth, Albert B., 690 Carlstedt-Duke, Jan, 399 Chen-Kiang, Selina, 2515 Courtois, Gilles, 1183 Dekker, Peter J. T., 7364 Carmichael, Ellen P., 408 Chevallier-Multon, M. C., 39 Cowan, Nicholas J., 2478, DeLamarter, John F., 7180 Came, Alexander F., 7612 Chi, Tianhuai, 7045 7625 Delaney, Shawn, 4039 Carnevali, Francesca, 6479 Chien, Kenneth R., 4432 Crabtree, Gerald R., 4760 de Lera, Maria T. Lain, 4770 Carothers, Adelaide M., 5085 Childs, Geoffrey, 1746 Craft, Cheryl M., 5593 Del Gatto, Fabienne, 5461 Carpenter, Christopher L., Chin, William W., 1719 Craig, Elizabeth A., 5637 Delic, Jozo, 4875 1657 Chinault, A. Craig, 5931 Crater, Dinene, 7652 Della Porta, G., 358 Carr, Dianne P., 6530 Chipev, Constantin C., 613 Cress, W. Douglas, 6314 Delovitch, Terry L., 1471 Carrasco, Daniel, 5195 Chittenden, Thomas, 3975 Crews, Craig M., 6615 Del Rio, Samuel, 4776 Carrier, France, 4242 Chiu, Fung-Chow, 2765 Crimmins, Dan L., 7418 Delvoye, N. L., 6969 Carriere, Catherine, 7257 Choder, Mordechai, 6984 Cross, Frederick R., 3266 Delwel, Ruud, 4291 Carroll, Ann M., 3632 Choe, Soo Young, 2644 Crouch, Deborah, 3541 de Maddalena, Chiara, 1059 Carroll, Dana, 6897 Choi, Young-Chul, 5538 Crouzet, Marc, 5070 DeMaria, Christine T., 7652 Carroll, Susan M., 2971 Chow, Lionel M. L., 7112 Crow, Michael T., 6907 DeMartino, John C., 739 Carter, Mark, 1686 Chow, Robert L., 2478 Crute, Barbara E., 3324 Demignon, Josiane, 9 Carty, Michael P., 533 Christensen, Thorkil H., 6752 Cuddihy, Agnes E., 3505 DeNagel, Diane C., 3598 Casanova, Juan, 5725 Christgau, Stephan, 4223 Cuddihy, Agnes M., 2858 Denell, Rob, 2524 Caserta, Micaela, 6702 Chu, Peter, 1554 Cuif, Marie-H6lene, 7725 Deng, Chuxia, 2134 Cassady, A. Ian, 3191 Chu, Tung Tammy, 4939 Culbertson, Michael R., 2041, Deng, Tiliang, 2104, 3675 Castafi6n, Maria J., 4953 Chuang, Lee-Ming, 6653 2870 Denhardt, David T., 1471 Cathala, Guy, 1641 Chung, Hui-Min M., 3734 Cullen, Bryan R., 6180 Denis, Deborah, 2882 Cato, Andrew C. B., 7850 Chung, Stephen, 1456 Cunningham, David B., 449 Denninger, Anne, 7850 Catron, Katrina M., 2354 Churchill, Alice C. L., 7782 Cunningham, John M., 3272 Denny, Christopher T., 7393 Cattanach, Bruce M., 4928 Cigan, A. Mark, 506, 4618 Curran, Tom, 3213, 3782, 5479 Dent, Paul, 4539 VOL. 13, 1993 AUTHOR INDEX iii

DePinho, Ronald A., 2456, Druck, Teresa, 1507 Fattaey, Ali R., 7267 Fukuhara, Hiroshi, 2309, 2765 Dubois, Evelyne, 2586 Faucette, Leo, 6012 2315, 3882 DeRaemy-Schenk, Duchaine, Jean, 5427 Faure, Michel, 2815 Fukui, Yasuhisa, 4409 Anne-Marie, 7180 Duckett, Colin S., 1315, 6283 Favot, Paula, 3191 Fukushima, Kohtarou, 6367 DeRose, Margaret L., 2971 Duckworth, Brian C., 1657 Fawcett, Timothy W., 4736 Funabiki, Tetsunori, 4291 Dershowitz, Ann, 391 Duke-Cohan, Jonathan S., Fay, David, 6640 Furdon, Paul J., 6678 Desai-Yajnik, Vandana, 5057 7708 Fay, David S., 5829 Futcher, Bruce, 5659 Deschamps, St6phane, 6819 Dumont, Mark E., 6442 Fay, Fred, 6052 Deshmukh, Mohanish, 2835, Dunn, Timothy L., 3191 Fazioli, Francesca, 5814 Gaber, Richard F., 638 4860 Durand, B., 6375 Fearon, Kathleen, 6304 Gafner, Jeffery, 4416 Desiderio, Stephen, 6223 Durkovich, David, 942 Featherstone, Mark S., 257 Gahlmann, Reinhold, 6752 DeSimone, Susan M., 3641 Duwel, Annette, 7971 Feder, John N., 105 Gaikwad, Joel, 5450 DesJardins, Edward, 5710 Dyer, Michael A., 7457 Fekete, Donna M., 2604 Gaire, Mireille, 561 Destroismaisons, N. M., 6969 Dyson, Nicholas, 7813 Felder, S., 1449 Galang, Christina K., 4609 D'Eustachio, P., 1497, 2942 Eberhardt, Norman L., 6509 Felsenfeld, Gary, 3990, 4632 Galasso, Debora L., 7587 Devault, Alain, 7380 Eberle, Gertrud, 421 Fendly, Brian M., 2247 Galceran, Joan, 1433 de Vries-Smits, Alida M. M., Eck, Stephen L., 6530 Feng, P., 266 Galey, Angela L., 4776 155, 7248 Eckhardt, Laurel A., 3530 Fenton, Matthew, 6231 Galili, Gad, 3487 Dey, Anup, 6629 Edman, Jeffrey C., 1962 Fenton, Matthew J., 1332 Gallie, Brenda L., 4588 Dhand, R., 3567 Edstrom, Jan-Erik, 1583 Feramisco, James R., 2104, Gallie, Daniel R., 5331 Dhand, Ritu, 4600 Edwalds-Gilbert, Gretchen, 2497 Galligan, Michael A., 5907 Diaz-Golpe, Victor, 4770 3472 Ferguson, Kenneth, 6558 Galo, Gregory J., 749 Diaz-Meco, Maria T., 1290, Edwards, Gwynneth, 953 Ferguson-Smith, Anne C., Galson, Deborah L., 1332, 4770, 7645 Ehrenman, Karen, 7652 4928 2929 Dickson, Clive, 5781 Ehrlich, Melanie, 6810 Fernandes, Patricia M. B., Gan, Song-Qing, 613 Dickson, Judith A., 6393 Eilers, Andreas, 3245 1013 Ganchi, Parham A., 7826 Dieckmann, Carol L., 4203 Eisenbeis, Charles F., 6452 Ferraresi, G., 358 Ganem, Don, 659 Diehl, J. Alan, 1769 Eisenman, Robert N., 5216, Ferrus, Alberto, 1433 Gans, Hayley, 831 Dietrich, Paula, 3734 7540 Fewell, Joseph W., 7439 Ganster, Raymond W., 3650 Di Fiore, Pier Paolo, 5814 Ekker, Stephen C., 6941 Fields, Stanley, 3765 Gao, FenBiao, 3494 Dignard, Daniel, 1 Elder, Robert T., 1489 Filipowicz, Witold, 6403 Gao, Pei-Qing, 690 DiMaio, Daniel, 4137 Elgin, Sarah C. R., 2802 Finbloom, David S., 1634, Gao, Yijie, 2478 Di Mauro, Ernesto, 6702 Eliceiri, George L., 4382 Garcia, Arnold V., 4432 Ding, Dali, 3773 3984, 7515 Garoufalis, Jenny, 6231 Ellison, Eldora L., 7531 Finco, Timothy S., 3301 Dini, Peter W., 7334 Emerick, Victoria L., 1137 Garraway, Isla P., 3841 Dinouel, Nathalie, 2309, 2315 Finlay, Cathy A., 301 Garrell, Joan, 3514 Emery, P., 6375 Finnegan, David J., 1042 DiPaolo, Tiziano, 2152 Emeson, Ronald B., 5999 Garrett, Stephen, 2870 Di Segni, Gianfranco, 3424, Firestone, Gary L., 2031 Garsky, Victor M., 953 End, P., 3567 Fisher, L. F., 6044 3434 Eng, Wai-Kwong, 6012 Gartner, Anton, 2069 Dixon, Jack E., 4784 Fitzgerald-Hayes, Molly, Gashler, Andrea L., 4556 Engel, James Douglas, 4011 4351, 4691 Dixon, Kathleen, 533 Engelke, Ute, 2858 Gatewood, Joe M., 4523 Dobrzanski, Pawel, 1572 Engels, William R., 7006 Fleming, Timothy P., 762 Gatignol, Anne, 2193 Dodd, Jonathan, 114 Engler, Peter, 571 Flick, Jeffrey S., 5861 Gauen, Lisa K. Timson, 5877, Doetschman, Thomas, 3311, Ennist, David L., 3951 Flynn, Daniel C., 7892 6385 4115 Epple, Jurgen, 5020 Foiani, Marco, 4618 Gauss, George H., 3900 Dolde, Christine, 1130 Erhardt, Peter, 7645 Foord, Orit, 1378 Gavalas, Anthony, 4784 Domanico, Susan Z., 3598 Erikson, R. L., 6615 Forget, Diane, 2846 Gazzolo, Louis, 89 Dombek, Kenneth M., 4391 Ernst, Patricia, 2982 Fornace, Albert J., Jr., 4242 Ge, Ying, 2031 Dominguez, Isabel, 1290, 4770 Erny, Bettina, 6723 Forne, Thierry, 1641 Geahlen, Robert L., 1675 Dominska, Margaret, 2697 Errede, Beverly, 57, 2069, Fortin, Nathalie, 2152 Gearing, David P., 2384 Dong, Fan, 7774 5738 Foster, Rosemary, 3792 Geiduschek, E. Peter, 942 Dong, Jing Ming, 4986 Eschenlauer, Julie B., 3015 Fotedar, Arun, 5450 Geiser, John R., 7913 Dorfler, Petra, 6024 Escobedo, Jaime A., 3706, Fouquet, Claire, 4884 Gekeler, Volker, 5020 Dornreiter, Irena, 809 5560 Fowler, Timothy, 184 Gelbart, William M., 6357 Doros, Linda, 2952 Estable-Puig, Mario, 1619 Fox, Thomas D., 4806, 5418 Gelfman, Claire M., 2623 Dosil, Mercedes, 6572 Estruch, Francisco, 3872 Franzetti, Bruno, 2614 Gelinas, Celine, 6733 Douglas, Michael G., 341 Evans, Mark J., 5175 Franzoso, Guido, 6157 Geng, Yiping, 4894 Dove, William F., 449 Evans, Rosemary B., 6147 Frauman, Albert G., 1554 Gerlach, Valerie L., 3015 Dowd, Diane R., 5907 Eversole-Cire, Pamela, 4928 Freeman, Barbara A., 506 Gervais, Francois G., 7112 Downing, James R., 6336 Freytag, Svend O., 3093 Gesnel, Marie-Claude, 5461 Downward, Julian, 1903 Fabian, John R., 7170 Friedberg, Errol C., 1051 Gessner, Reinhard, 1933 Draetta, Giulio, 5122 Fahrner, Timothy J., 5794 Friedman, Alan D., 2141 Gething, Mary-Jane, 877 Drake, Lisa, 1273 Fajardo, J. Eduardo, 4648, Frohli, Erika, 1824 Ghersa, Paola, 7180 Drew, Paul D., 6157, 6629 7295 Fry, M. J., 3567 Ghivizzani, Steven C., 2162 Dreyfuss, Gideon, 4301, 5762, Falck-Pedersen, Erik, 578, Fu, Kok-Chin, 6690 Ghosh, David, 852 6114 3472 Fuchs, Elaine, 3176 Ghosh, Maya R., 5629 Driggers, Paul H., 588, 2258, Fantl, Wendy J., 3706 Fujisawa-Sehara, Atsuko, Ghosh, Rita, 6992 3951 Farabaugh, Philip J., 2081, 7153 Ghysdael, Jacques, 668 Driller, Jonathan, 6615 2091 Fujita, Donald J., 7408 Gietzen, Darryl, 184 Driscoll, Claire T., 4233 Farnham, Peggy J., 1610 Fujita, Takashi, 3557 Gilbert, David M., 462 Driscoll, Donna M., 7288 Fassler, Jan S., 63 Fujitani, Yoshio, 3027 Gilbert, Emmanuelle, 5461 Drissi, Rachid, 2309, 2315 Fath, I., 39 Fujiwara, Haruhiko, 1424 Gilbert, Jeff D., 3093 Drouin, Jacques, 2342 Fattaey, Ali, 6501 Fukabori, Yoshitatsu, 4513 Gilks, C. Blake, 1759 iv AUTHOR INDEX MOL. CELL. BIOL.

Gille, Hendrik, 123 Gruss, Hans-Jurgen, 4284 Harrison, P. R., 5582 Holbrook, Nikki J., 4736 Gillespie, David, 5370 Gualberto, Antonio, 1264 Hartman, Anne-Ren6e, 3623 Holewa, Beatrix, 6416 Gillespie, Frances P., 2952 Guarente, Leonard, 5981 Hartshorne, Toinette, 144 Holland, Michael J., 2623 Gilmour, David S., 2593 Gudas, Lorraine J., 2919 Hartzog, Grant A., 44 Holloway, Jeffrey M., 3042 Ginty, David D., 6260 Guerra, Maria-Jose M. Diaz, Hasegawa, Kiminori, 5513 Holm, Connie, 3445 Gish, G., 3567 7725 Hatch, Christopher L., 984 Holmberg, Steen, 7604 Gishizky, Mikhail L., 1728 Guerrini, Luisa, 3202 Hattori, Seisuke, 4409 Holmes, Edward W., 5854 Givol, David, 2224 Guertin, Michel, 1619 Hattori, Toshio, 2787 Holmes, William E., 2247 Gleason, Shannon L., 3951 Guha, Abhijit, 7203 Hauschka, Stephen D., 2753 Holt, Jeffrey T., 3821 Glendening, Candace L., 367 Gumucio, Deborah L., 3272 Hauser, Craig A., 4609 Honegger, A. M., 1497 Glockshuber, Rudolf, 4174 Gunaratne, Preethi H., 5931 Hauser, Janet, 533 Hong, Wanjin, 6435 Goddard, John P., 7372 Guo, Ming, 1104 Hauss, Charlotte, 561 Hood, Leroy, 5691 Goetz, Jean, 561 Guo, Wentong, 443 Haussler, Carol A., 5907 Horabin, Jamila I., 7734 Goff, Sabra C., 5604 Guo, Zijian, 7836 Haussler, Mark R., 5907 Horabin, J. I., 1408 Goga, Andrei, 4967 Gupta, Jyothi, 4703 Hauswirth, William W., 2162 Horikoshi, Masami, 7859 Goguel, Valerie, 6841 Gupta, Shashi, 4125 Havlik, Marie H., 1728 Horn, Friedemann, 276 Gold, Jennifer S., 4793 Gustafsson, Jan-Ake, 399, Hay, Nissim, 383, 2432, 5710 Horner, Jim, 2456, 2765 Gong, Da-Wei, 7859 2504 Hayashida, Kazuhiro, 1440 Horowitz, David S., 2959 Gong, Qihui, 911 Gutmann, David H., 487 Hayes, Mary K., 6442 Horta, M. Fatima, 6690 Gong, Shih S., 3202 Hearing, P., 6375 Horton, Robert M., 4374 Gonzales, Felicidad A., 4928 Haarer, Brian K., 7864 Heath, Carol M., 7612 Hosler, Betsy A., 2919 Goodhart, Paula J., 953, 7802 Haas, Susan, 3103 Hecht, Norman B., 6547 Hou, Jinzhao, 3907 Goodnight, JoAnne, 2578 Habener, Joel F., 7080 Hedjran, Farah, 5999 Hou, Wei-Min, 1657 Goodwin, Graham H., 7612 Hagen, David C., 6866 Heery, David M., 462 Housman, David E., 2929 Gopal-Srivastava, Rashmi, Hagiwara, Masatoshi, 4852 Heideman, Warren, 6274 Houtteman, Scott W., 1489 7144 Hagman, James, 3392 Heimbrook, David C., 953, Howard, Tom, 18 Gordenin, Dmitry A., 5315 Hahm, Kyungmin, 2982 7802 Howe, Chin C., 6621 Gordon, Jennifer, 3103 Hahn, Peter J., 4459 Heinlein, Ruth, 1371 Howe, J. Greg, 2655 Gorski, David H., 3722 Hahnenberger, Karen M., Heinrich, Julia N., 2020 Howles, Philip, 3311 Gosselin, Joe, 2952 4578 Heinrich, Peter C., 276 Howley, Peter M., 775, 4918, Goswami, Shyamal K., 1222 Hai, Tsonwin, 7180 Heitman, Joseph, 5010 5186 Goto, Masahide, 1385 Hair, Alan, 7925 Heldin, Carl-Henrik, 4066 Hromas, Robert, 7393 Gotoh, Yukiko, 3067, 6427 Halegoua, Simon, 3146 Helfman, David M., 2993 Hsu, Cecilia L., 4826 Gottlieb, Christopher A., 711 Halfon, Marc S., 5898 Helin, Kristian, 6501, 7267, Hsu, Karl, 4233 Gottlieb, Keith, 690 Haliotis, Tina, 1471 7813 Hsu, Wei, 2515 Gottlieb, Paul D., 6147 Hall, Benjamin D., 3424, 3434 Hellmann-Blumberg, Utha, Hu, P., 1449, 7677 Gout, I., 3567 Hall, Christine, 4986 4523 Hu, Qianjin, 5560 Goya, Luis, 2031 Hall, Michael N., 5010 Helm, Kenneth W., 238 Huang, David C. S., 2420 Goyer, Charles, 4860 Hallberg, Elizabeth M., 3050 Helmer, Elizabeth, 5725 Huang, Eng-Shang, 1315 Goyon, Christophe, 373 Hallberg, Richard L., 3050 Henriquez, Ruben, 5010 Huang, Hui-Chuan, 6190 Gradin, Katarina, 677 Halsell, Susan R., 3773 Hensold, Jack O., 2929 Huang, Jiakang, 7476 Grafi, Gideon, 3487 Hambor, John E., 7056 Hermann, Thomas, 7698 Huang, Jin, 3734 Graham, Geoffrey J., 5245 Hamel, Diane, 1619 Hernandez, Nouria, 1251 Huang, Jing, 5216 Gralla, Jay D., 4572, 7469 Hamilton, Jenny A., 3577 Hernandez, Rudy R., 6393 Huang, Kimberly N., 3125 Grandin, Nathalie, 2113 Han, Wei, 5549 Herrmann, Friedhelm, 4284 Huang, Pearl S., 953 Granok, Howard, 2802 Hanafusa, Hidesaburo, 4648, Herschbach, Brenda M., 4029 Huber, Hans E., 953, 7802 Grant, Caroline E., 4186 7295, 7507 Heydari, Ahmad R., 2909 Hubler, Laura, 6274 Graupner, Gerhart, 7698 Hanahan, Douglas, 4223 Hicks, James B., 551 Huebner, K., 1497 Graves, Reed A., 4753 Hanawalt, Philip C., 970 Hickson, Ian D., 5370 Huebner, Kay, 1507 Gray, John G., 6678 Hancock, John F., 2420 Hidaka, Kyoko; 6469 Huh, Gene S., 5301 Greaves, Richard, 5233 Handa, Hiroshi, 1385 Hiebert, Scott W., 3384, 6336 Huibregtse, Jon M., 775, 4918 Green, Jennifer M., 3598 Haneji, Tatsuji, 4146 Hieshima, Kunio, 2787 Hulster, Andrea, 1708 Greenberg, Michael E., 5034, Haneline, Stephen A., 6678 Hieter, Philip, 1212 Hume, David A., 3191 6260 Hanke, Jeffrey H., 5593, 7056 Higgins, Kimberly A., 3802 Hung, Deborah T., 4760 Greene, Warner C., 7826 Hannig, Ernest M., 506 Higgs, Doug, 2298 Hung, Peggy, 7399 Greenleaf, Arno L., 4214 Hannink, Mark, 1769 Hiles, I., 3567 Huppi, Conrad, 3557 Greenwald, Iva, 7133 Hannon, K., 6044 Hines, Lori K., 5843 Hurban, Patrick, 7101 Griggs, David W., 4999 Hansen, Hans, 4728 Hinnebusch, Alan G., 1920, Hurley, Elizabeth A., 821 Grillo, Mary, 3002 Hansen, Lori J., 659 3541, 4618, 5099 Hurley, Tamara R., 1651 Grimes, H. Leighton, 1759 Harashima, Satoshi, 2050 Hintz, Mary F. McCarthy, Hwang, Lena, 3392 Grimley, Philip M., 7515 Harder, Kenneth W., 4679 4523 Hyman, Linda E., 5159 Grippo, Joseph F., 2258 Harding, Heather P., 3113 Hirano, Keiko, 4745 Hyman, Robert, 1651 Groner, Bernd, 7303 Hardison, Ross, 5439 Hirano, Toshio, 3027 Hynes, Richard O., 5301 Gros, Philippe, 7380 Hardy, Serge, 5943 Hirokawa, Kaoru, 2787 Gross, David S., 727 Harlow, Ed, 1194, 6501, 7267, Hirschfeld, Steven, 2258 Ichikawa, Tomoyuki, 5513 Grosschedl, Rudolf, 3392 7813 Hirsh, Jay, 4549 Idler, William W., 613 Groudine, Mark, 5647 Harlow, Patricia, 993 Hiscott, John, 6231 Igarashi, Kenichi, 1634, 3984 Grove, Matthew, 5276 Harootunian, Alec, 4852 Hitomi, Yoshiaki, 1943 Ignjatovic, Mette W., 7604 Gruda, Maryann C., 961 Harrison, Jeffrey K., 4539 Hockensmith, Joel W., 5323 Ihle, James N., 1788, 3350, Gruenwald, Stefan, 3522 Harrison, John R., 5168 Hoefsloot, Lies H., 7774 4291, 7577 Grummt, Ingrid, 6723 Harrison, Kathy, 2899 Hoffman-Liebermann, Ikeda, Masa-aki, 7029 Grunberger, Dezider, 5085 Harrison, Leonard C., 1554 Barbara, 841 Iler, Nancy, 2354 Grunwald, Didier, 1415 Harrison, Paul R., 6290 Hoffmann, Birgit, 7698 Imai, Yoshiyuki, 80, 6427 VOL. 13, 1993 AUTHOR INDEX v

Imhof, Axel, 4174 Jones, Peter A., 4928 Kimchi, Adi, 1415, 5255, 7942 Krebsbach, Paul H., 5168 Imperiale, Michael J., 2011 Jones, Richard S., 6357 Kindle, Karen L., 2277 Kreider, Brent, 2269 Ina, Sawako, 4098 Jones, Tania A., 4986 King, Alexandra A. J., 2235 Kreider, Brent L., 4291 Inglis, Stephen C., 6931 Jongens, Thomas, 184 King, Peter H., 3494 Kress, Michel, 2815 Innis, Jeffrey W., 2718 Josephson, Betty, 7636 Kingston, Robert E., 749 Kretzner, Leo, 5216 Irie, Kenji, 3067, 3076, 4745 Jove, Richard, 2011 Kinzy, Terri Goss, 506 Kroeger, Paul E., 3370 Ishikawa, Fuyuki, 4301 Ju, Qida, 1173 Kirk, Karen E., 4465 Krook, Anna, 1471 Ishikawa, Hajimne, 1424 June, Carl H., 1911 Kirkman-Correia, Celia, 3765 Krude, Torsten, 1059 Ishikawa, Hideaki, 6733 Kishida, Shosei, 2061 Krueger, James G., 7507 Isshiki, Hiroshi, 1854 Kabat, David, 5670 Kishimoto, Tadamitsu, 1854 Kruger, Brian, 831 Ito, Yoshiaki, 6733 Kadonaga, James T., 1238 Kitada, Kunio, 4445 Krumm, Anton, 5647 Itoh, K., 5582 Kaelin, William G., 1610 Kiar, Avihu, 891 Krysan, Patrick J., 2688 Ittmann, Michael M., 1998 Kafatos, Fotis C., 5898 Kiausner, Richard D., 4342 Krystal, Gerald, 7577 Ivarie, R., 6044 Kahn, Axel, 9, 7725 Klein-Hitpass, Ludger, 421, Kuang, Anna A., 2536 Ivey-Hoyle, Mona, 7802 Kahn, C. Ronald, 6653 6416 Kubo, Takeo, 4049 Iwasaki, Takeshi, 5043 Kaibuchi, Kozo, 2061 Klemenz, Roman, 1824 Kubrich, Michael, 7364 Kaiser, Michael W., 3015 Kiemm, Dwight J., 2822 Kudrycki, Katarzyna, 3002 Kamachi, Yusuke, 5206 Klemsz, Michael, 7393 Kuehl, W. Michael, 2858, Jabrane-Ferrat, Nabila, 6810 Kamps, Mark P., 351 Klenova, Elena M., 7612 3505 Jackowski, Suzanne, 1522 Kan, Mikio, 3907 Kleymann, Gerald, 5020 Kuff, Edward L., 7439 Jackson, Aimee L., 2899 Kang, Sang-Mo, 2536 Klippel, Anke, 5560, 6661 Kung, Ching, 2041 Jackson, Anne U., 2718 Kannan, Perry, 4174 Klocker, Helmut, 7850 Kunkel, Gary R., 4670 Jackson, David A., 2401 Kanno, Yuka, 3951 Klucher, Kevin M., 1238 Kunsch, Charles, 3850, 6137 Jacobs, Yakop, 7321 Kapeller, Rosana, 6052, 7708 Knezetic, Joseph A., 4632 Kunz, Jeannette, 5010 Jacobson, Marty R., 1119 Kaplan, David R., 2203 Knighton, Daniel R., 5122 Kupperman, Erik, 4477 Jacquet, Michel, 2815 Karantza, Vassiliki, 6640 Knippers, Rolf, 1059 Kuraoka, Akio, 6367 Jahng, Kwang-Yeop, 1013 Karin, Michael, 2104, 3675 Ko, Christopher H., 638 Kurata, Takeshi, 4409 Jamrich, Milan, 2456 Kash, Shera F., 2718 Ko, Linda J., 4011 Kurjan, Janet, 2554 Jan, Lily Y., 105 Kashishian, A., 6889 Kobayashi, Ayako, 4049 Kuroda, Shinya, 72 Jan, Yuh-Nung, 105 Kashishian, Adam, 1737 Kobayashi, Marilyn, 5331 Kurokawa, Tsutomu, 4251 Jane, Stephen M., 3272, 5604 Kaslow, David C., 7349 Kobayashi, Naoko, 248 Kurtz, Stephen, 1306 Janney, M. J., 6044 Kaspar, Felizia, 7850 Kobori, Joan A., 5691 Kurzbauer, Robert, 6024 Janssen, Ottmar, 7708 Kass, Stefan U., 7372 Koch, C. Anne, 5225 Kusafuka, Takeshi, 3027 Jaspers, Stephen, 2822 Kassavetis, George A., 942 Koeffler, Phillip H., 3291 Kushner, Peter J., 3042 Jeang, Kuan-Teh, 2193 Kastner, Berthold, 307 Koehler, Carla M., 5567 Kwan, Ivy, 6231 Jeanteur, Philippe, 1641 Kaszubska, Wiweka, 7180 Koeller, David M., 5266 Kwon, Byoung S., 6690 Jelinek, Warren R., 7793 Katagiri, Tatsuo, 5513 Koga, Makoto, 626 Kwon, Yunhee Kim, 6547 Jenkins, Nancy A., 3722 Kataoka, Tohru, 769, 4087 Kohlhaw, Gunter B., 5702 Kwong, Jeffrey, 6385 Jenner, Alison J., 6931 Kavathas, Paula, 7056 Kohno, Kenji, 877 Jentsch, Stefan, 1371 Kawakami, Takatoshi, 4531 Koizumi, Hirotaka, 6690 Labrie, Claude, 1697 Jia, X.-C., 266 Kaziro, Yoshito, 3706 Kokubo, Tetsuro, 7859 Lacoste, Judith, 6231 Jiang, Chengyu, 2401 Kazlauskas, Andrius, 133 Koller, Antonius, 5010 LaFayette, Peter R., 238 Jiang, Weidong, 4884 Kazmierczak, Pam, 7782 Kolman, John L., 2971 Laforgia, S., 1497 Jiang, Yajuan, 6211 Ke, Yunbo, 1565 Koltin, Yigal, 6012 Lagrange, Thierry, 2614 Jiang, Ying, 4572 Kedes, Larry, 6752 Komiya, Tohru, 7153 Lai, Char-Chang, 1345 Jiang, Y.-P., 2942 Kedinger, Claude, 561 Komiyama, Sohtaro, 6367 Lai, Ming-Yang, 432 Jinks-Robertson, Sue, 3937 Keen, Nick J., 3434 Kondo, Jun, 1516 Lake, Robert J., 7793 Jinno, Atsushi, 4146 Keene, Jack D., 3494 Kondo, Noriaki, 1516 Lake-Bullock, Helene, 7122 Jirik, Frank, 4679 Keiper, Brett D., 4953 Kondo, Tatsuya, 4251 Lakhe-Reddy, Sujata, 7288 Johansen, Finn-Eirik, 4640 Kellems, Rodney E., 2718 Kondoh, Hisato, 5206 Lambie, Eric J., 6170 John, Susan, 6201 Keller, Gilbert A., 2247 Kong, Yanfeng, 5943 Lan, Y., 1599 Johnson, Alexander D., 4029 Keller, Gordon, 473 Konieczny, Stephen F., 5943 Lang, Walter, 649 Johnson, Anthony L., 4445 Keller, Susanna R., 3324 Konopka, James B., 6876 Lanigan, Thomas M., 6079 Johnson, David G., 6314 Kelley, Clair, 5738 Konsolaki, Mary, 5898 Lanoix, Jacqueline, 2846 Johnson, Gary L., 2822, 5877 Kelly, Ruth E., 2971 Korb, Martin, 1565 Larner, Andrew C., 1634, Johnson, Lee F., 1565, 4894 Kenna, Margaret, 341 Kornberg, Roger D., 1872 3984, 7515 Johnson, Maureen R., 6799 Kennedy, Marion, 473 Kornberg, Thomas B., 7961 LaRue, Helene, 1619 Johnson, Pauline, 5771 Kerppola, Tom K., 3782, 5479 Korsmeyer, Stanley J., 3686, Lau, Anna, 2456 Johnson, Penny, 1456 Kessler, Ofra, 6211 5469 Lau, Lester F., 6124 Johnson, Peter F., 6919 Key, Joe L., 238 Kost, Thomas A., 6678 Lau, Y.-F. C., 4323 Johnson, Randall K., 6012 Khachi, Anita, 3841 Kotani, Kei, 72 Lauderdale, James D., 7596 Johnson, Richard, 2081 Khalili, Kamel, 3103 Kovary, Karla, 1911 Laurent, Monique, 1183 Johnson, Stephen L., 831 Kiefer, Paul, 5781 Kowalik, Timothy F., 1315 Lawrence, Jean-Jacques, 1415 Johnson, Stewart P., 1283 Kielland-Brandt, Morten C., Kowalski, David, 5360 Lazar, Mitchell A., 3113 Johnson-Schlitz, Dena M., 7604 Kozak, Christine A., 2919, Lazaris-Karatzas, Anthoula, 7006 Kienzle, Bernadette K., 2706 3951 7358 Johnston, Gerald C., 1034, Kihara-Negishi, Fumiko, 7747 Kozmik, Zbynek, 6024 Learmonth, Dianne, 6393 7553 Kikuchi, Akira, 72 Krainc, Dimitri, 2564 Leathers, Valerie, 5331 Johnston, Leland H., 4445 Kikuchi, Takanobu, 4400 Krainer, Adrian R., 2993 Lee, Arianna, 2152 Johnston, Mark, 4999 Kilvert, M. Alison, 1296 Kramer, James M., 626 Lee, Christine S. L., 3577 Jolicoeur, Christine, 4223 Kim, Dae-Hyuk, 7782 Kraus, Virginia B., 4714 Lee, David C., 320 Jones, Carol, 2929 Kim, Jae Bum, 4753 Kraus, William E., 4714 Lee, Dong Kun, 6253 Jones, Don, 1371 Kim, Young-Joon, 174 Kream, Barbara E., 5168 Lee, Eric, 3990 vi AUTHOR INDEX MOL. CELL. BIOL.

Lee, Han S., 4860 Lichten, Michael, 373 Luhrmann, Reinhard, 307 Martinez, Carmen, 3514 Lee, James, 2247 Lichtler, Alexander C., 5168 Luk, Daniel, 3782 Martinez, Diane, 7288 Lee, Jeng-Shin, 7487 Lickteig, Ronald L., 2822 Lund, Frances E., 3929 Martinez, Ernest, 2258 Lee, Joseph M., 7112 Lieber, Michael R., 1363, Lunkes, Astrid, 7566 Martins, Tim, 6558 Lee, Kuan Rong, 1883 3464, 3900 Lunsford, Lynn B., 7393 Marton, Matthew J., 3541 Lee, Kyung S., 3067, 3076, Lieberman, Paul M., 1232 Lupold, D. Shelley, 7232 Mason, Thomas L., 6304 5843 Lieberman, Stephanie, 3530 Luse, Donal S., 3860 Massague, Joan, 7239 Lee, Margaret S., 6586 Liebermann, Dan A., 841 Lutticken, Claudia, 276 Massari, Mark E., 792 Lee, Mary G.-S., 3734 Lilienbaum, Alain, 89 Lynch, Kevin R., 4539 Massie, Bernard, 5427 Lee, Mi-Ock, 7698 Lim, Hong Hwa, 4986 Masuda, Esteban S., 7399 Lee, Seewoo, 727 Lim, Louis, 4986 Ma, Averil, 5216 Matheny, Cali, 6858 Lee, Sheng-Chung, 432 Lin, Anning, 2104 Ma, Junli, 831 Mathews, Michael B., 1697 Lee, Yu-May, 432 Lin, Grace Y., 6393 Maarse, Ammy C., 7364 Matoskova, Brona, 5814 Lees, Emma M., 1194 Lin, Jian-Xin, 6201 Maassen, J. Antonie, 155 Matsuda, Michiyuki, 4409 Lees, Jacqueline A., 7813 Lin, Julia C., 7080 Macdonald, Paul N., 5907 Matsui, Mayumi, 4049 Lefebvre, Louis, 5393 Lin, Weei-Chin, 6223 Macdonald, Susan G., 6615 Matsumoto, Kunihiro, 3067, Le Guellec, Katherine, 2815 Lindsten, Tullia, 1911 Macdonald-Bravo, Heather, 3076, 4745 Lehman, Chris W., 6897 Lingrel, Jerry B., 4115 2020 Matsumoto, Sumie, 4251 Lehmann, Jurgen M., 7698 Linial, Maxine L., 3623 Mach, B., 6375 Matsushima, H., 7447 Leiden, Jeffrey M., 1911 Linnenbach, Alban J., 1507 Mache, R6gis, 2614 Matsushime, Hitoshi, 4146 Leifer, Dana, 2564 Liou, Hsiou-Chi, 3557 Machida, Yasunori, 4745 Mattei, Marie-Genevieve, le Maire, Marc, 6819 Lioubin, Mario N., 5348 MacInnes, Mark A., 6393 4505, 5195 Lemarchandel, Valerie, 668 Lipke, Peter N., 2554 Mack, Susan, 7232 Matthews, Keith R., 720 Lemischka, Ihor R., 6572 Lipshitz, Howard D., 3773 MacNicol, Angus M., 4197 Matthias, Patrick, 1547 Lemmon, Sandra K., 521 Lipsick, Joseph S., 4423, 7334 Madaule, Pascal, 5567 Matts, Robert L., 1920 Lemoine, Yves, 462 Lipton, Stuart A., 2564 Madden, Benjamin, 869 Matunis, Erika L., 5323, 6114 Lenardo, Michael J., 2536 Lis, John T., 3456 Madsen, Cort S., 2162 Matunis, Michael J., 4301, Leonard, Warren J., 852, 6201 Little, Randall D., 6600 Maeda, Tatsuya, 5408 5323, 6114 Leonardsson, G., 266 Littman, Dan R., 5620 Maekawa, Hideaki, 1424 Maxwell, Michele M., 1847 Leong, Sally A., 7091 Litvinov, Sergey, 2891 Magdelenat, Henri, 4875 May, Evelyne, 1415 Leonhardt, Susan A., 6304 Liu, Chau-Ching, 6690 Maher, Maureen, 3850 May, Pierre, 1415 LePage, David F., 3722 Liu, Keyi, 7596 Maher, Veronica M., 4276 May, William A., 7393 Lepage, Pierre, 7380 Liu, Leroy F., 6190 Maihle, Nita J., 5888 Mayeda, Akila, 2993 Lerbs-Mache, Silva, 2614 Liu, Vivian F., 7222 Maina, Flavio, 4600 McBride, George, 4513 Lessnick, Stephen L., 7393 Liu, Xingquan, 5225 Maio, Joseph J., 5245 McBride, Kevin, 600 Leu, Tzeng-Horng, 7892 Liu, Xuan, 3291 Maire, Pascal, 9 McCammon, Mark, 341 Leung, Kwanyee, 6283 Liu, Youhua, 1836 Maiyar, Anita C., 2031 McCarthy, Susan A., 3255 Lev, Sima, 2224 Livi, George P., 6012 Maldonado, Edio, 6733 McConaughy, Betty L., 3424, Levin, David E., 3067, 3076, Livingston, David M., 367, Malik, Sohail, 6253 3434 5843 3975 Malim, Michael H., 6180 McCormack, Wayne T., 821 Levine, Arnold J., 4107 Lo, Patrick C. H., 1104 Malkova, Anna L., 5315 McCormick, Daniel J., 869 Levine, Arthur S., 533 Lobachev, Kirill S., 5315 Mamessier, Pascale, 3882 McCormick, Frank, 2497, Levine, Todd D., 3494 Lobanenkov, Victor V., 7612 Manfioletti, Guidalberto, 4976 6615 Levinson, Arthur D., 2666 Lodes, Michael J., 7036 Mangasarian, Karen, 3202 McCormick, J. Justin, 4276 Levy, Adam D., 626 Lodish, Harvey F., 98 Mann, Karen P., 2411 McCullough, Andrew J., 1323, Levy, David E., 196 Lohka, Manfred J., 1480 Mannironi, Cecilia, 984 4485, 7689 Levy, J. B., 1497 Lommel, Lori, 970 Manser, Edward, 4986 McDermott, John C., 2564 Levy, Naomi, 7942 Lonergan, Matthew, 6629 Mao, Xianzhi, 7496 McEachern, Michael J., 551 Levy-Wilson, Beatriz, 1534 Long, Laura, 7652 Mao, Xiaohong, 1911 McEntee, Kevin, 248 Lew, Daniel J., 3744 Longati, Paola, 4600 Maquat, Lynne E., 1892, 3359 McEvoy, James L., 7091 Lewis, Brian C., 7393 Longo, John A., 4459 Maraia, Richard J., 4233 McEwan, lain J., 399 Lewis, Stephanie, 2366 Look, Thomas, 7813 Marchioni, Marcella, 6479 McGovern, Elizabeth S., 762 Lewis, Susanna M., 1078 Lopez, Gabriela, 3042 Marchuk, Douglas A., 487 McGrew, Jeffery T., 4691 Lhotak, Vladimir, 7071 Lorch, Yahli, 1872 Marcote, Maria J., 5122 McKeehan, Wallace L., 3907, Li, Mian, 6490 Lord, Kenneth A., 841 Marcu, Kenneth B., 2858 4513 Li, Q., 4844 Lorenz, Jennifer J., 6678 Marcus, Gregory A., 5981 McKinsey, Timothy A., 1769 Li, Qiliang, 7636 Losson, R6gine, 462 Marder, Brad A., 6667 McKnight, G. Stanley, 7666 Li, W., 6889 Lou, Hua, 1323, 4485 Marechal, Vincent, 4107 McLaughlin, Jami, 4967 Li, Wen-Lu, 2247 Lowenberg, Bob, 7774 Marekov, Lyuben N., 613 McLaughlin, Megan M., 6012 Li, Wen-Zhuo, 7836 Lowry, Charles V., 6071 Marengere, Luc E. M., 5225 McLean, Carol, 1042 Li, Xianqiang, 2377 Lowy, Douglas R., 6462, Margolis, Frank L., 3002 McMahon, Martin, 6241 Li, Xuan, 3282 6799, 7718 Marion, Tony, 5749 McWhirter, John R., 7587 Li, Yi-Ping, 3714 Lozano, Guillermina, 3415 Marion, Tony N., 869 Medema, Rene H., 155, 7248 Li, Yue, 1610 Lozano, Jose, 4770 Markova, Nedialka G., 613 Medin, Jeffrey A., 6157 Li, Yun-Ping, 6064 Lu, Cha-Fen, 2554 Marks, Michael S., 588, 2258 Meier, Joseph T., 1078 Li, Zhenlin, 89 Lu, Qin, 2802 Marois, James, 6231 Meijer, Michiel, 7364 Liang, Beirong, 4365 Lu, Xian Ping, 6509 Maroo, Anjli, 6640 Meinkoth, Judy L., 2104, 4477 Liang, Hong, 638 Lublin, Douglas M., 6385 Marshall, Christopher J., 2420 Melamed, Dror, 5255 Liang, T. Jake, 7476 Luche, Ralf M., 5749 Martin, Mary Ellen, 1222 Melnikova, Irena N., 3324 Liao, Warren S.-L., 6766 Ludlow, John W., 367 Martin, Patrick, 7257 Mennone, John, 7056 Liao, Xiaoling C., 2126 Lueders, Kira K., 7439 Martin, Patrick K., 4760 Menold, Marisa M., 2870 Liao, Xiubei, 1353 Luetke, Karen, 3167 Martin, Sandra L., 5383 Merika, Menie, 3999 Libermann, Towia A., 5957 Luetteke, Noreen C., 320 Martinez, Antoine, 7725 Merillat, Nicola, 5999 VOL. 13, 1993 AUTHOR INDEX vii

Merrell, Kevin T., 7487 Morimoto, Richard I., 1392, Nagashima, Kazuo, 4409 Oh, Charles Euk, 7961 Messenguy, Francine, 2586 1983, 3370 Nagata, Kiyoshi, 4077 O'Hare, Peter, 5233 Messier, Helen, 5450 Morisaki, Takayuki, 5854 Nagata, Toshi, 6157 Ohba, Ken-Ichi, 1516 Metherall, James E., 5175 Morishita, Kazuhiro, 4291 Nakabeppu, Yusaku, 4157 Ohki, Misao, 1943 Methot, Nathalie, 6789 Morozov, Viktor E., 7439 Nakae, Kazuto, 3027 Ohlsson, M., 266 Metz, Richard, 5195 Morris, Gilbert F., 1697 Nakai, Akira, 1983 Ohshima, Yasumi, 626, 5613 Meulewaeter, Frank, 3340 Morris, J., 6044 Nakajima, Koichi, 3027 Ohta, Shigeki, 4077 Meulia, Tea, 5647 Morris, N. Ronald, 4465 Nakajima, Shigeo, 5907 Ohya, Yoshikazu, 4260 Meyers, Rachel E., 7953 Morrisey, Joanne, 7349 Nakamura, Shun, 4409 Oikawa, Tsuneyuki, 1943 Meyers, Shari, 6336 Morrison, Deborah K., 1163, Nakamura, Toshihide, 4745 Oishi, Michio, 6036 Michael, Gregory J., 4986 7170 Nakashima, Torahiko, 6367 Okada, Tomoyo, 769 Michaeli, Tamar, 6558 Morrissey, D., 1599 Nakatani, Yoshihiro, 7859 Okazaki, Satoshi, 1424 Michalides, Rob J. A. M., Morrissey, John P., 2469 Namba, Masayoshi, 6036 Okret, Sam, 331 2891 Morrow, Bernice E., 1173, Nantermet, Pascale V., 3301 O'Leary, Eileen, 1933 Michaud, William A., 1212 1283 Narayanan, Ramaswamy, Oleksa, Lisa M., 7288 Michelitch, Merrilyn, 3937 Morse, B., 1497 3802 Oliff, Allen, 953, 7802 Middleton, Kim, 4884 Mortin, Mark A., 4214 Naruo, Ken-ichi, 4251 Olson, Eric N., 4714 Mietz, Judy A., 5186 Morton, Cynthia C., 5604 Natori, Shunji, 4049 Oltz, Eugene M., 6223 Mignotte, Vincent, 668 Moscat, Jorge, 1290, 4770, Navot, Nir, 1378 O'Prey, Jim, 6290 Mikesell, Glen E., 3792 7645 Neel, Benjamin, 6157 Oren, Moshe, 1415, 7942 Miki, Toru, 762 Mosley, Bruce, 2384 Negishi, Yoichi, 7747 Orkin, Stuart H., 2235, 3999, Milbrandt, Jeffrey, 861, 5794, Mosser, Dick D., 5427 Neigel, Joseph E., 207 5604 6858 Mougey, Edward B., 5990 Neiman, Paul E., 7612 Orr, Ann, 984 Miles, Lynette, 953 Mougneau, Evelyne, 184 Neish, Andrew S., 6283 Oshima, Robert G., 1815, Miller, Alexandra C., 4416 Mount, Stephen M., 1104 Nelson, Christian, 7321 2214, 6742 Miller, Carl W., 3291 Mouw, Andrea R., 861 Nelson, Karen K., 521 Oshima, Yasuji, 2050, 3076 Miller, Charles A., 5360 Mowa, N. Rao, 5010 Nelson, Nancy, 588 Oshimura, Mitsuo, 6036 Miller, Christopher P., 7080 Moyers, Julie S., 2391 Nemer, Martin, 993 Osley, Mary Ann, 28 Miller, Ira J., 2776 Mudgett, John S., 6393 Nemer, Mona, 600 Ostertag, W., 5582 Milos, Patrice, 2401 Muhlrad, Denise, 5141 Nesic, Dobrila, 3359 Ostman, Arne, 4066 Min, JingJuan, 4167 Mui, Alice L.-F., 1440, 7577 Neugebauer, Karla M., 4023 Ou, Jing-Hsiung, 443 Minato, Toshinori, 769 Mukai, Tsunehiro, 6469 Nevins, Joseph R., 2411, Ouellette, Andre J., 1933 Minichiello, Liliana, 5814 Mukai, Yukio, 2050 6314, 7029 Ouyang, Qian, 1796 Miralpeix, Montserrat, 7418 Muller, Alexander, 4967 Newlon, Carol S., 391 Overbeek, Paul, 18 Miranti, Cindy K., 6260 Muller, Eric G. D., 1779, 7913 Ney, Paul A., 3272, 5604 Ozato, Keiko, 588, 2258, Mischak, Harald, 2578 Mumby, Marc C., 2104 Neznanov, Nickolay, 2214 3951, 5907, 6157, 6629 Miskimins, W. Keith, 1796 Municio, Maria M., 4770 Neznanov, Nickolay S., 1815 Misra, Ravi P., 6260 Munioz, Ruben M., 6849 Nguyen, Hannah, 6231 Paddon, Christopher J., 4618 Misra, R. Rita, 1002 Muraosa, Yasushi, 7881 Nguyen, Van T. B., 4432 Paddy, Michael R., 6102 Mitchell, Aaron P., 2172 Murdoch, Kirstie J., 6819 Nibbs, R. J. B., 5582 Pahl, Paula M. B., 2899 Mitchell, David L., 4276 Murnane, John P., 977 Nicolas, Robert H., 7612 Pajak, Laura, 3311 Mittelmeier, Telsa M., 4203 Murphy, Kenneth M., 4793 Nielsen, Lena, 1583 Palmiter, Richard D., 320, Miura, Osamu, 1788 Murphy, Shawn P., 1392 Nienhuis, Arthur W., 3272, 5266 Miura, Retsu, 2787 Murphy, Steven M., 5290 5604 Pan, Guohua, 3167 Miyajima, Atsushi, 1440 Murphy, Theresa L., 4793 Nikolaropolous, Stathis, 4513 Panayotou, G., 3567 Miyakawa, Isamu, 2309, 2315 Murre, Cornelis, 792, 3522, Nilson, Laura A., 4137 Panayotou, George, 4600 Miyamoto, Masaaki, 4251 7163 Nishida, Eisuke, 3067, 6427 Panning, Barbara, 3231 Miyazaki, Mutsuo, 2061 Musacchio, J. M., 1497, 2942 Nishida, Yoshimitsu, 769, Papadopoulos, Nickolas, 6907 Mizuno, Kazuya, 5513 Muscarella, Donna E., 1023 4087 Papageorge, Alex G., 7718 Moch, Clara, 9 Musgrove, Elizabeth A., 3577 Nishikawa, Shin-Ichi, 2224 Papayannopoulou, T., 4844 Modolell, Juan, 3514 Mushinski, J. Frederic, 2578 Nishimoto, Takeharu, 6367 Papayannopoulou, Thalia, Moir, Janet M., 1590 Muslin, Anthony J., 4197, Nishimura, R., 6889 473, 2298 Molinar-Rode, Ricardo, 3213 6661 Nishio, Yukihiro, 1854 Pape, Louise K., 5990 Mondellini, P., 358 Muthuchamy, Mariappan, Nitsch, Doris, 4494 Parisi, Melissa A., 1951 Mondino, A., 6889, 7677 3311 Nogi, Yasuhisa, 114, 2441 Park, John W., 2247 Montgomery, Pamela A., 2247 Muto, Akihiko, 1440 Noguchi, Tetsuro, 5195 Park, Kyoungsook, 6621 Montminy, Marc R., 4852 Myers, Alan M., 5567 Nolan, Garry P., 3557 Park, Min S., 6393 Monzini, N., 358 Myers, Martin G., Jr., 6653, Nomiyama, Hisayuki, 2787 Park, Morag, 6711 Moore, Claire L., 5159 7418 Nomoto, Satoshi, 4745 Parker, Henry R., 993 Moore, Paul A., 1666 Myers, Richard M., 44, 4311 Nomura, Masayasu, 114, 2441 Parker, Keith L., 861 Moore, Tracey D. E., 1962 Myler, Peter J., 6832, 7036 Nonet, Genevieve H., 2971 Parker, Laura L., 1675 Morabito, Stefano, 6479 Myles, Gary M., 5348 Normington, Karl, 877 Parker, Roy, 5141 Morales, Tony H., 207 North, Melanie T., 6819 Parkhurst, Susan M., 3773 Morange, Michel, 4875 Nabel, Elizabeth G., 6283 Northrop, Jennifer L., 1779 Parmar, Kalindi, 4967 Mordret, Guy, 4679 Nabel, Gary J., 1315, 6283, Novak, Kristine D., 2536 Parsons, J. Thomas, 785, 7892 Morella, Karen K., 2384 6530 Ny, T., 266 Parsons, Sarah J., 2391 Morfin, John-Paul, 5999 Nabeshima, Yo-Ichi, 7153 Patel, Chandrashekhar V., Morgan, David O., 5290 Nabeshima, Yoko, 7153 Oakes, Melanie, 2441 1264, 3722 Morgan, Garry T., 7925 Nadal-Ginard, Bernardo, O'Brien, Thomas, 3456 Patel, Geeta, 2269 Morgan, James I., 3213 2564, 4939 Oda, Shinya, 4157 Patel, Indravadan R., 6678 Morgan, William F., 6667 Nag, Dilip K., 2324 Ogasawara, Naotake, 5043 Paterson, Hugh F., 7612 Morgan, William R., 7133 Nag, Mihir K., 4382 Ogata, Toshihiko, 6036 Patrick, Denis R., 953 Mori, Kazutoshi, 877 Nagao, Ronald T., 238 Ogimoto, Mami, 5513 Paulin, Denise, 89 viii AUTHOR INDEX MOL. CELL. BIOL.

Paulovich, Amanda G., 2835 Privalsky, Martin L., 2366, Rivera, Victor M., 6260 Sambrook, Joseph, 877 Paulson, K. Eric, 4365 5970 Rivier, Jean, 4852 Samid, Dvorit, 4416 Paulweber, Bernhard, 1534 Probst, Hans, 5020 Robbins, Shira, 1507 Samson, Leona, 7213 Pause, Arnim, 6789 Prochownik, Edward V., 2011 Robins, Diane M., 6326 Samuels, Herbert H., 5057, Pawson, T., 3567 Proffitt, John H., 5469 Robinson, Gordon W., 2706 5725 Pawson, Tony, 5225, 5500, Prorock, Christine, 6733 Robinson, Lucy C., 2870 Samuels, Michael L., 6241 7071 Pross, Hugh, 1471 Robitaille, Lynda, 600 Sandgren, Eric P., 320, 5266 Paya, Carlos V., 4770 Prywes, Ron, 4640 Robles, Robert, 2247 Sandhofer, Friedrich, 1534 Payne, William E., 4351 Pullen, Jeffrey K., 4374 Robson, Craig N., 5370 Santa Maria, Thylma, 196 Pease, Larry R., 4374 Purnell, Beverly A., 2593 Rock, Charles O., 1522 Santerre, R. F., 6044 Pederson, Thoru, 1119 Purucker, Mary E., 5604 Rodgers, Linda, 6558 Sanz, Laura, 1290, 4770 Pelech, Steven L., 4679 Pyrc, Jania J., 1507 Rodrigues, Gerard A., 6711 Sap, J., 1497, 2942 Roeder, Robert G., 6253, 7859 Pellegrini, Maria, 928, 934 Qian, Lian, 1686 Sarge, Kevin D., 1392, 3370 Pendergast, Ann Marie, 1728, Roemer, Terry, 4039 Sasaki, Anna W., 1686 Qiu, Ting Hu, 320 Rogers, Bryan, 184 4967 Quatannens, Brigitte, 7257 Sasaki, Hiroyuki, 4928 Pepin, Normand, 6231 Rogers, Melissa B., 2919 Sasaki, Takuya, 72 Queale, William S., 6201 Rohrschneider, Larry R., 5348 Perez, Christophe, 2182 Quong, Melanie W., 792 Sathe, Ganesh M., 6012 Perez, Jose R., 3802 Rolfes, Ronda J., 5099 Satoh, Takaya, 3706 Pergola, Fabrizia, 3464 Raaka, Bruce M., 5725 Rollins, Martha B., 4776 Satyamoorthy, Kapaettu, 6621 Perkins, Edward, 5315 Rabin, Stuart J., 2203 Rom, William N., 3831 Saule, Simon, 7257 Perkins, Neil D., 1315, 6530 Radvanyi, Francois, 4223 Roman, Dragos G., 4342 Saulino, Ann M., 487 Raghu, B., 4382 Romaniuk, Paul J., 6819 Savenelli, Neal, 2742 Peruski, Leonard F., Jr., 2822 Romeo, Paul-Henri, 668 Pesce, Susan, 7874 Rahuel, Cecile, 668 Sawada, Jun-Ichi, 1385 Raju, Kaliannan, 4400 Romine, Margaret F., 690 Sawada, Shinichiro, 5620 Peterlin, B. Matija, 6810 Roome, Janet M., 408 Peters, Gordon, 5781 Ramcharan, Shari, 3937 Sawaya, Patricia L., 3860 Ramsay, Scot, 6290 Rosamond, John, 2899 Schaefer, Andrew W., 7652 Peterson, Kenneth R., 4836 Rosbash, Michael, 2126, 6841 Petes, Thomas D., 2324, 2697 Randall, Troy D., 3929 Schafer, Mireille, 1708 Rapoport, Micha J., 1471 Rose, David, 3445 Schafer, Reinhold, 1824 Petryniak, Bronislawa, 1911 Rosen, Craig A., 1666, 3802, Petzold, Audrey S., 7864 Rapp, Ulf R., 7645 Schafer, Ulrich, 1708 Rapp, William D., 7232 3850, 6137 Schaffhausen, Brian, 1657 Pfahl, Magnus, 6509, 7698 Rosenberg, Naomi, 3890, 4967 Pfanner, Nikolaus, 7364 Rashid, Mohammad B., 5043 Schaller, Michael D., 785 Rassow, Joachim, 7364 Rosenblatt, Jody, 184 Schalling, Martin, 2929 Pfeifer, Gerd P., 5490 Rathbun, Gary, 6223 Rosenfeld, Michael G., 5999 Schauer, Susan, 6393 Pfeuffer, Isolde, 1155 Rathjen, Peter D., 7971 Rosenwald, Igor B., 7358 Schaufele, Fred, 3042 Philippe, Michel, 2815 Ratnasabapathy, Roth, Mark B., 4023 Schedl, P., 1408 Phillips, Robert A., 4588 Ratneswaran, 1251 Rothenberg, Ellen V., 228 Schedl, Paul, 7522, 7734 Piatigorsky, Joram, 7144 Raychaudhuri, Gopa, 5323 Rotter, Varda, 1378 Scheffner, Martin, 775, 4918, Pick, Leslie, 5549 Raychaudhuri, Pradip, 6537 Roulston, Anne, 6231 5186 Pickle, William, II, 1273 Raymondjean, Michel, 7725 Rousseau, Stephane, 4904 Scheinman, Robert I., 6089 Pierani, Alessandra, 3401 Read, Laurie K., 6832 Rousset, Solange, 2309, 2315 Scheller, Arno, 6326 Pierce, Susan K., 3598 Reddy, E. Premkumar, 2269 Rovera, Giovanni, 2269 Schiestl, Robert H., 2697 Pierotti, M. A., 358 Reddy, P. M. Sekhar, 1093, Rowader, Kathleen E., 2401 Schildkraut, Carl L., 6600 Pikarsky, Eli, 891 2298 Rowe, David W., 5168 Schiller, John T., 6462 Pilch, Duane R., 984 Reed, Randall R., 5805 Rowley, Adele, 1034 Schindler, Chris, 3245, 3951 Pimental, Ruth A., 4365 Reed, Steven I., 2113, 3744 Rozek, Dieter, 5490 Schjerling, Peter, 7604 Pifia, Benjamin, 5981 Reeder, Mina C., 5907 Ruben, Steven M., 1666, 3850 Schlessinger, J., 1449, 1497, Pinkham, Jennifer L., 5829 Reeder, Ronald H., 649, 2644 Rudd, Christopher E., 7708 2942, 6889, 7677 Pifiol-Roma, Serafin, 5762 Reich, Nancy C., 3756 Ruiz-Carrillo, Adolf, 4904 Schlichter, Julia B., 6442 Pipas, James M., 3255 Reichelt, Julia, 307 Ruppert, J. Michael, 3811 Schlissel, Mark S., 5679 Piwnica-Worms, Helen, 1675 Reichman, Charles, 4648 Rushforth, Alice M., 902 Schmid, Carl W., 4523 Platt, Timothy H. K., 6600 Reimund, Bernard, 561 Russell, Paul, 2286 Schmid, Roland M., 1315 Plaza, Serge, 7257 Reinke, Valerie, 3415 Russo, Andrew F., 6079 Schmidt, Anja, 5010 Pleiman, Christopher M., 5877 Reith, W., 6375 Russo, Mark W., 6858 Schmidt, Emmett V., 7358 Plowe, Christopher V., 7349 Reitman, Marc, 3990 Russo, Patrick, 7836 Schmidt, Martin C., 3650 Plumb, Mark, 5276 Remboutsika, Eumorphia, Ryan, James J., 711 Schmitt, Mark E., 7935 Poellinger, Lorenz, 677, 2504, 5702 Ryffel, Gerhart U., 421, 6416 Schnapp, Andreas, 6723 4365 Renaud, Jean, 4904 Ryseck, Rolf-Peter, 1572, 2020 Schnapp, Gisela, 6723 Pongratz, Ingemar, 677, 2504 Repke, Heinrich, 7708 Schneider, Claudio, 4976 Ponzetto, Carola, 4600 Resar, Linda M. S., 1130 Saari, Bonnie, 902 Schneider, Robert J., 1971 Popperl, Heike, 257 Resh, Marilyn D., 3084 Saatcioglu, Fahri, 3675 Schonthal, Axel, 2104 Posada, James, 2546 Resnick, Michael A., 5315 Sadowski, Paul D., 3167 Schorr, Elke, 1155 Pouponnot, Celio, 3401 Reynolds, Albert B., 7892 Safer, Brian, 5604 Schrader, Karen A., 5805 Pourhosseini, Atossa, 4432 Reynolds, Richard J., 6393 Saito, Haruo, 5408 Schreiber, Stuart L., 4760 Pouwels, Karin, 7774 Reynolds, Wanda, 6742 Saito, Kazuyoshi, 1332 Schreiber-Agus, Nicole, 2456, Powers, Scott, 1345 Rhoadhouse, Molly, 1119 Saito, Midori, 7813 2765 Prado, Antonio, 1433 Richardson, Arlan, 2909 Saito, Yoriko, 739 Schroeder, Andrew J., 4691 Prakash, Louise, 7757 Riedel, Heimo, 4728 Sakoda, Tsuyoshi, 2061 Schuetze, Scott, 5670 Prakash, Satya, 7757 Riggs, Karen J., 7487 Saksela, Kalle, 3698 Schuler, Mary A., 1323, 4485, Prasad, K. V. S., 7708 Riggs, Michael, 6558 Saleque, Shireen, 7487 7689 Prentice, Holly, 749 Rimoldi, Omar J., 4382 Salminen, Marjo, 9 Schulman, Ira G., 3156 Prentice, Howard, 6752 Rine, Jasper, 4260 Salvati, Anna Laura, 6479 Schultz, Michael C., 2644 Prescott, John, 3472 Ripmaster, Tracy L., 7901 Salvetti, Anna, 89 Schutz, Gunther, 4494 Prior, Concepcion, 3882 Rivera, Richard R., 7163 Samac, Sanja, 6810 Schuuring, Ed, 2891 VOL. 13, 1993 AUTHOR INDEX ix

Schwarz, John J., 4714 Shuntoh, Hisato, 2332 Stehelin, Dominique, 7257 Szabo, Susanne J., 4793 Schweighoffer, F., 39 Siddiqui, M. A. Q., 1222 Stein, Arnold, 7596 Sze, Ji-Ying, 5702 Sclafani, Robert A., 2899 Sidorova, Julia, 1069 Stein, Bernd, 3964, 7191 Scollon, Maureen, 1507 Siebelt, Friederike, 1155 Steinberg, Robert A., 2332 Taccioli, Guillermo, 6223 Scott, Edward W., 543 Siebenlist, Ulrich, 6157 Steiner, Bart, 6558 Tahaoglu, Elvan, 5245 Scott, Gary K., 2247 Siegrist, C. A., 6375 Steiner, Noemi C., 4578 Tainsky, Michael A., 4174 Scott, Martin L., 3557 Siekevitz, Miriam, 6490 Steinert, Peter M., 613 Takada, Ritsuko, 7859 Scotto, Luigi, 3588 Sigal, Catherine T., 3084 Stein-Izsak, Cathy, 3002 Takahashi, Eiichi, 6036 Sedivy, John M., 6640 Sikorski, Robert S., 1212 Steitz, Joan A., 703, 3135 Takahashi, Ryoya, 2909 Seeger, Christoph, 659 Silvennoinen, O., 1497 Stenberg, Paula E., 5670 Takahashi, Yuzi, 5613 Seegert, Dirk, 3245 Silverman, Gary A., 5469 Stephany, David A., 6157 Takai, Yoshimi, 72, 2061 Sefton, Bartholomew M., 1651 Silverman, Neal, 5981 Stern, David B., 2277, 7232 Takaishi, Kenji, 72 Segars, James H., 2258, 6157 Simon, Alexander M., 5133 Stern, David F., 5829 Takamatsu, Nobuhiko, 1516 Seidel-Rogol, Bonnie L., 6778 Simon, M. Celeste, 2235 Sternberg, Paul W., 626 Takase, Masanori, 3076 Seiwert, Scott D., 3135 Sims, Simon H., 690 Sterner, Deborah A., 2677 Takatsuki, Kiyoshi, 2787 Sekiguchi, Mutsuo, 4157 Sin, Wun Chey, 4986 Stevens, Audrey, 341, 4826 Takeda, Takashi, 3027 Sekiguchi, Takeshi, 6367 Singer, Richard A., 1034, 7553 Stevens, Kimberly, 2401 Talarico, Daniela, 1998 Seko, Chisako, 4251 Singh, Harinder, 6452 Stewart, Mary J., 2524 Tam, Rose, 2152 Sela, Ilan, 3487 Singh, Keshav K., 7213 Steyaert, Alain, 2846 Tanaka, Kayoko, 80 Selinger, David, 1353 Singh, Mallika, 3611 Stiles, Charles D., 7203 Tanaka, Keiji, 4146 Seng, Beth A., 1507 Singh, Paramjeet, 6435 Stillman, Bruce, 3811 Tanaka, Nobuyuki, 4531 Senkel, Sabine, 421 Sithanandam, Gunamani, 7645 Stillman, David J., 1805, 5524 Tanaka, Shinya, 4409 Serfling, Edgar, 1155 Skolnik, E. Y., 7677 Stinnett, Sandra W., 6678 Tang, Bor Luen, 6435 Seth, Alpna, 4125 Skup, Daniel, 2846 St.-Jacques, Benoit, 1847 Tang, Terry, 6157 Setzer, David R., 4776 Slack, Jill K., 3632 St. John, Tom, 6558 Tanguay, Robert, 5331 Seurinck, Jef, 3340 Slansky, Jill E., 1610 Stolk, John A., 4023 Tani, Tokio, 5613 Shaanan, B., 1497 Smale, Stephen T., 2982, 3841 Stone, James C., 7311 Taniguchi, Tadatsugu, 4531 Shalloway, David, 1464 Small, Michael B., 2432 Storb, Ursula, 571, 6452 Tantravahi, JogiRaju, 578 Shamah, Steven M., 7203 Smart, William C., 5749 Stratowa, Christian, 4953 Tao, Wen, 5771 Shapiro, Alan M., 5679 Smeyne, Richard J., 3213 Stripp, Barry R., 3860 Tarn, Woan-Yuh, 1876, 1883 Shapiro, Robert A., 3424 Smiley, Bob L., 7036 Strniste, Gary F., 6393 Tassan, Jean Pierre, 2815 Sharif, Mohammed, 2366 Smiley, James R., 3231, 6064 Stroke, Ilana L., 3765 Taylor, Doris A., 4714 Sharon, Terri, 1971 Smith, Austin G., 7971 Strong, Randy, 2909 Taylor, J. David, 6678 Sharp, Phillip A., 7953 Smith, Christopher W. J., Stroumbakis, Nikolaos D., Taylor, Milton W., 918 Sharrocks, Andrew D., 123 4939 5898 Taylor, Stephen J., 1464 Shaw, Andrey S., 5877, 6385 Smith, C. K., II, 6044 Stuart, Kenneth D., 6832, Taylor, Susan S., 5122 Shaw, Peter E., 123 Smith, David F., 869 7036 Tazi, Jamal, 1641 Sheehan, Kevin M., 1363 Smith, Jessica G., 2688 Stuebing, Elizabeth W., 993 Teh, Hung-Sia, 5771 Sheldon, Michael, 1251 Smith, Michael, 5393 Stueland, Constance S., 3744 Teng, Christina T., 1836 Shen, C.-K. James, 1093, 2298 Smith, Paul, 4986 Stuiver, Maarten H., 7163 Teng, James, 3660 Shen, Jie, 4549 Smith-Monroy, Constance A., Stumph, William E., 5918 TenHarmsel, Alyssa, 2742 Shen, Liya, 3530 2706 Sturgill, Thomas W., 4539 Tennant, Bud C., 659 Shen, Weiqun, 3650 Smit-McBride, Zeljka, 2366 Stutz, Francoise, 2126 Teo, Mabel, 4986 Shenoy-Scaria, Amiya M., Snyder, Benjamin W., 2952 Stuve, Laura L., 4311 Tertoolen, Leon G. J., 7248 6385 Snyder, Michael, 6170 Su, Lihe, 4728 Tessner, Teresa G., 1522 Shepard, H. Michael, 2247 Soeller, Walter C., 7961 Subler, Mark A., 6849 Theisen, Manfred, 7666 Sherman, Fred, 6442, 7836 Sollner-Webb, Barbara, 5990 Sudol, Marius, 7507 Theodor, Livia, 1686 Sherwood, Peter W., 28 Sommer, Marvin, 1238 Suen, Chen-Shian, 1719 Therrien, Marc, 2342 Shewchuk, Brian, 5439 Somogyi, Paul, 6931 Suen, Ki-Ling, 5500 Thomas, David Y., 1 Shi, Ergang, 3907 Sonenberg, Nahum, 4860, Sugimoto, Katsunori, 1013 Thomas, Kirk R., 2134 Shi, Yang, 7487 6789, 7358 Sugino, Akio, 4445 Thomassin, Helene, 1619 Shiba, Tadayoshi, 1516 Song, Yuru, 5918 Sukhatme, Vikas P., 4556 Thompson, Craig B., 821, Shibahara, Shigeki, 7881 Songyang, Zhou, 4648 Sullivan, William P., 869 1911 Shibata, Yosaburo, 6367 Sor, Fr6deric, 2309, 2315 Sumrada, Roberta A., 5749 Thorey, Irmgard S., 2214, Shibuya, Masabumi, 4146 Sott, Claudia, 4284 Sun, Benjamin I., 6941 6742 Shimanuki, Mizuki, 6427 Souza, Augustine E., 6832 Sun, Shao-Cong, 7826 Thorner, Jeremy, 5861 Shimekake, Yoshiyuki, 4077 Sowadski, Janusz M., 5122 Sun, Xiao Jian, 7418 Thorsness, Peter E., 5418 Shimizu, Kimiko, 1943 Speck, Nancy A., 3324 Sundberg, Holly A., 7913 Thummel, Carl S., 7101 Shinohara, Toshimichi, 4400 Spector, Deborah H., 1238 Sung, Patrick, 7757 Tiefenbrun, Nava, 5255 Shinomiya, Tomoyuki, 4098 Spencer, Charlotte A., 1296 Surani, M. Azim, 4928 Tikhonenko, Andrei T., 3623 Shirahige, Katsuhiko, 5043 Spevak, Walter, 4953 Sussel, Lori, 3919 Tillman, Mike, 5749 Shirakawa, Fumihiko, 1332 Spiegelman, Bruce M., 4753 Sutherland, Robert I., 3577 Ting, Jenny P.-Y., 2858 Shirataki, Hiromichi, 2061 Sprague, George F., Jr., 6866 Suzow, Joseph, 2141 Tocque, B., 39 Shlomai, Joseph, 7399, 7766 Sprenger, Frank, 1163 Suzuki, Noboru, 769, 4087 Toczyski, David P., 703 Shoelson, S. E., 1449 Spurr, Nigel K., 4986 Swaminathan, Sowmya, 4556 Toda, Takashi, 6427 Shoelson, Steven E., 4648, Stacey, Dennis W., 6799 Swanson, Maurice S., 2730, Toft, David O., 869 6653 Stadnyk, Andrew W., 7036 6102 Tokumitsu, Hiroshi, 7399 Shore, David, 1306, 3919 Stamatoyannopoulos, G., 4844 Sweeney, Kimberley J. E., Toledano, Michel B., 852 Showers, Mark O., 739 Stamatoyannopoulos, George, 3577 Tolias, Peter P., 5898 Shu, Hong Bing, 6283 2298, 4836, 7636 Sweeney, Rosemary, 4814 Tollervey, David, 2469 Shu, Hsiao-Hsueh, 6832 St-Arnaud, Rend, 1590 Symcox, Marina M., 2332 Tomanin, Rosella, 6064 Shu, Mei-Di, 2655 Stashenko, Philip, 3714 Symington, Lorraine S., 3125 Tontonoz, Peter, 4753 Shu, Youmin, 3050 Steenbergen, Renske, 7163 Symonds, Holly S., 3255 Torres, Richard, 2456, 2765 x AUTHOR INDEX MOL. CELL. BIOL.

Torroja, Laura, 1433 Vassbotn, Flemming S., 4066 Watkins, John F., 7757 Witte, Owen N., 1728, 4967 Touw, Ivo P., 7774 Vaughn, George P., 7901 Watts, Colin K. W., 3577 Wittenberg, Curt, 1013 Trachsel, Hans, 4860 Vaux, David L., 7000 Watts, Julian D., 5771 Witzgall, Ralph, 1933 Trautman, Jonathan K., 6897 Veals, Susan A., 196 Waye, John S., 6520 Wojciechowicz, Donald, 2554 Travis, Adam, 3392 Veillette, Andre, 7112 Weaver, Christine A., 861 Wold, Barbara, 3221 Tremblay, Stephane, 600 Verdone, Loredana, 6702 Weaver, David T., 6957, 7222 Wolf, Alex J., 4057 Trepicchio, William L., 7457 Verhoeven, Els, 2891 Webb, Andrew C., 1332 Wong, Kwok-kin, 7487 Trinh, Frank, 852 Verma, Inder M., 2635, 7429 Webb, Paul, 3042 Wong, Sandy, 207 Troppmair, Jakob, 7645 Vidal, Marc, 7813 Weber, Heather W., 928 Wong, Siew Heng, 6435 Trosclair, Melissa M., 1163 Vidali, Giorgio, 1306 Weber, Heike, 421 Wong, William T., 5814 Trueblood, Cynthia Evans, Vierling, Elizabeth, 238 Weber, Michael J., 4539, 6241 Wood, William I., 2247 4260 Vierra, Craig, 7321 Webster, Melanie K., 2031 Woodson, Sarah A., 1137 Truong, O., 3567 Vimaladithan, A., 2081 Weeks, John, 4214 Woody, Charles O., 5168 Tsai, Alex Y. M., 5408 Vincent, Christopher K., 1264 Wegenka, Ursula M., 276 Woolford, John L., Jr., 2835, Tsai, Robert Y. L., 5805 Viola, Anna-Maria, 2309 Weiner, Alan M., 5377 4860, 7901 Tsai, Wen-Hai, 432 Virelizier, Jean-Louis, 1290, Weintraub, Harold, 5216 Worthylake, David K., 6897 Tsang, Shirley V.-M., 28 4770 Weir, M., 1599 Wrana, Jeffrey L., 7239 Tsay, Yi-Fang, 2835 Virshup, David M., 1202 Weiss, Elizabeth A., 2411 Wright, Anthony P. H., 399 Tsay, Yim H., 2706 Virta-Pearlman, Valerie J., Weissinger, Eva M., 2578 Wrighton, Christopher, 4657 Tschudi, Christian, 720 5931 Weissman, Irving L., 7000 Wu, Bo, 2909 Tsichlis, Philip N., 1759 Vitale, James, 2952 Wellems, Thomas E., 7349 Wu, Carl, 3481 Tsien, Roger, 4852 Voellmy, R., 1599 Wellinger, Raymund J., 4057 Wu, Hongyun, 3415 Tsuboi, Akio, 7399 Voellmy, Richard, 2486 Wellington, Cheryl L., 5034 Wu, Jie, 4539 Tsuchida, Kozo, 1424 Vogel, Lee B., 7408 Wen, Wei, 4477 Wu, Lelia, 6615 Tsujino, Kayoko, 769 Vogt, Volker M., 1023, 7531 Weng, Andrew, 571 Wu, Qimin, 6778 Tsujita, Rumiko, 7747 Voisard, Christophe, 7091 Weremowicz, Stanislawa, Wu, Shuang, 1507 Tucker, Philip W., 5593, 5629 von Kessler, Doris P., 6941 5604 Wu, Xiaohua, 1051 Turkel, Sezai, 2081, 2091 Von Seggern, Daniel, 184 Werner-Washburne, Margaret, Tverberg, Lois A., 6079 Voos, Wolfgang, 7364 Xiao, Hong, 5829 1034 Xiao, Jia Hao, 961 Tyc, Kazimierz, 307 Vos, Jean-Michel H., 1002 Wesolowski-Louvel, Tyers, Mike, 5659 Vu, Minh N., 1686 Xiao, Wei, 7213 Micheline, 3882 Xiao, Zhixiong, 4691 Tyree, Curtis M., 5918 West, Robert W., Jr., 831 Tzfati, Yehuda, 7766 Xie, Kewei, 6170 Wada, Ken, 2061 Westby, Carl A., 6866 Xie Yue, 3191 Udvardy, Andor, 7522 Wadsworth, Samuel C., 2952 Westermark, Bengt, 4066 Xu, Baoji, 1951 Ullrich, A., 1449 Wadzinski, Brian E., 2822 Westphal, Heiner, 3990 Xu, Gangfeng, 2497 Ullu, Elisabetta, 720 Wagner, Andrew J., 383, 2432 Westwood, J. Timothy, 3481 Xu, Jianming, 3907 Unger, Tamar, 5186 Wagner, Belinda J., 7652 Wheat, William H., 2822 Xu, Peilin, 7091 Urdaci, Maria, 5070 Wahl, Alan F., 408 Whelan, James, 7180 Xu, Qunli, 7553 Urefia, J., 1449 Wahl, Geoffrey M., 2971 Whelen, Sally, 3434 Xu, Ruishu, 3660 Urlaub, Gail, 5085 Wahli, Walter, 2258 White, Kalpana, 3641 Xu, Xiang, 6733 Urso, Olgui, 4670 Walden, Paul D., 7625 White, Karen H., 5418 Xu, Xiang-Xi, 1522 Urushiyama, Seiichi, 5613 Walker, Lisa J., 5370 White, M., 1449 Uyttendaele, Hendrik, 7507 Walker, Stephen, 5233 White, Morris F., 6653, 7418 Yakura, Hidetaka, 5513 Wall, L. A., 6969 White, Ray, 2497 Yamada, Toshiyuki, 1943 Vaidya, Akhil B., 7349 Wall, Randolph, 3929 Whitelaw, Murray, 677, 2504 Yamaguchi, Kazuo, 1385 Vainberg, Irina E., 2478 Wallrath, Lori L., 2802 Whiteway, Malcolm, 1 Yamaguchi, Tsutomu, 2061 Valdivieso, M. Henar, 1013 Walsh, Kenneth, 1264, 3722 Whitsett, Jeffrey A., 3860 Yamamoto, Isamu, 6469 Vale, Wylie, 4852 Wang, Chung-Yih, 1911 Whyatt, Linda M., 7971 Yamamoto, Masayuki, 80, Valentine, Marcus, 7813 Wang, Fen, 3907 Wickner, Reed B., 4331 6427 Valius, Mindaugas, 133 Wang, H., 2942 Widner, William R., 4331 Yamashita, Shinya, 7859 Vallett, Shawn Millinder, 928 Wang, Huaming, 1805 Wieczorek, David F., 3311 Yan, Guochen, 4513 Van Alfen, Neal K., 7782 Wang, Jean Y. J., 7587 Wieser, Rotraud, 7239 Yang, Beom-Seok, 3093 van Bilsen, Marc, 4432 Wang, Jun, 4087, 7091 Wietzerbin, Juana, 2182 Yang, Elizabeth, 5469 van Buitenen, Carin, 7774 Wang, Li Chun, 3890 Wigler, Michael, 487, 6558 Yang, Nengyu, 1836 Van der Ploeg, Lex H. T., Wang, Michael M., 5805 Wilder, Sylvia, 1415 Yang, Yih-Sheng, 5593 3734 Wang, Qing, 918, 3324 Wiles, Michael V., 473 Yano, Kei-Ichi, 1385 van der Velden, Huub M. W., Wang, Shulin, 6572 Wilhelmsson, Anna, 2504, Yano, Ryoji, 114 1480 Wang, Shuwen, 3324 4365 Yao, Meng-Chao, 4814 van der Zon, Gerard C. M., Wang, Teresa S.-F., 809 Wilkinson, Miles F., 1686 Yarden, Anat, 5255 155 Wang, Tongtong, 163 Willard, Huntington F., 6520 Yarden, Yosef, 2224 Vande Woude, George F., Wang, Yi-Ching, 4276 Willett, Catherine E., 2623 Yashar, Beverly M., 5738 2546 Wang, Yue, 6841 Williams, Gregg T., 6124 Yeakley, Joanne M., 5999 Van Dyke, Michael W., 4174 Wang, YuKang, 5691 Williams, Lewis T., 3706, Yee, Carole L., 5186 Van Dyke, Terry, 3255 Wang, Ze, 5348 4197, 5560, 6661 Yee, Gene K., 4365 van Huijsduijnen, Rob Hooft, Wang, Zhigang, 1051 Wills, Zachary P., 6957 Yee, Karen, 5738 7180 Warburton, Peter E., 6520 Wilson, David B., 2235 Yen, T. S. Benedict, 443 Van Montagu, Marc, 3340 Warner, Jonathan R., 1173, Wilson, Scott M., 2730 Yew, Nelson, 2546 Vannier, David, 3919 1283 Wilson, Thomas E., 861, 5794 Yi, Taolin, 3350, 7577 van Oers, Nicolai S. C., 5771 Watanabe, Hajime, 1385 Winitz, Sim, 5877 Yim, Sun O., 4174 van Weeren, Pascale C., 7248 Watanabe, Sumiko, 1440 Wirth, Thomas, 1155 Yokota, Takashi, 1440 Varkey, Jacob, 6941 Watanabe, Yasuyuki, 3067 Wisdom, Ron, 2635, 7429 Yonish-Rouach, Elisheva, Varmus, Harold E., 7278 Waterfield, M. D., 3567 Wise, Jo Ann, 1353 1415, 7942 Vass, William C., 6799, 7718 Waterfield, Michael D., 4600 Wisely, G. Bruce, 6678 Yon Tsao, Twee, 1876 VOL. 13, 1993 AUTHOR INDEX xi

Yoon, Hye-Joo, 4884 Yu, Yie-Teh, 2564 Zenke, Frank T., 7566 Zhen, Mei, 1371 Yoshikawa, Hiroshi, 5043 Yun, Theodore J., 4374 Zenke, Martin, 3675 Zheng, Pan, 5829 Yost, Susan E., 5439 Zenzie-Gregory, Beatrice, Zhou, M., 1449, 6889 Youn, Byung-S., 6690 Zabolotny, Janice M., 961 3841 Zhou, Ming-Dong, 1222 Young, Elton T., 4391 Zachariae, W., 3058 Zhan, Qimin, 4242 Zhou, Xin, 4505 Young, John Ding-E, 6690 Zachariae, Wolfgang, 7566 Zhang, Jun-Wu, 7636 Zhou, Yu Chun, 1471 Young, Keith E., 6941 Zacksenhaus, Eldad, 4588 Zhang, Ke, 7718 Zhou, Zhaoqing, 2069 Young, Michael R., 5637 Zahler, Alan M., 4023 Zhang, Lei, 7782 Zhu, Gefeng, 1779 Young, Peter R., 6012 Zahner, Joseph E., 217 Zhang, Qingyi, 2298 Zhu, Hong, 4432 Young, Richard A., 6984 Zaitsu, Kiyoshi, 869 Young, Robert L., 3686 Zakian, Virginia A., 4057 Zhang, Wei, 7652 Ziegler, Steven F., 2384 Youssoufian, Hagop, 98 Zalkin, Howard, 4784 Zhang, Xian-Yang, 6810 Zitnik, G., 4844 Yu, Chao-Lan, 2011 Zamrod, Zulkeflie, 5918 Zhang, Xiao-kun, 7698 Zitomer, Richard S., 6071 Yu, Chiang, 6190 Zapp, Dirk, 421, 6416 Zhang, Yihong, 3831 Zoidl, Christiane, 421, Yu, Chun-Yuan, 2298 Zaret, Kenneth S., 2401 Zhao, Guang-Quan, 6416 Yu, Guoying, 63 Zassenhaus, Hans Peter, 4505 Zon, Leonard I., 5738 Yu, Joyce Y., 6393 4167 Zhao, Hong, 2081 Zuo, J., 1599 Yu, Loh-Chung, 977 Zdzienicka, Malgorzata Z., Zhao, Qi, 4505 Zutter, Mary, 5469 Yu, Yan, 5549 3464 Zhao, Yuhang, 7507 Zwart, Ronald, 792 SUBJECT INDEX VOLUME 13

3' RNA processing efficiency ADD1 AFAP-110 protein termination-competent RNA polymerase rat chicken embryo II elongation complexes, role in adipocyte determination and differenti- actin filaments, association with, 7892 generation of, 3472 ation, 4753 AFR1 protein 3' splice acceptor sites helix-loop-helix transcription factor, S. cerevisiae C. elegans, 626 4753 adaptation, promotion of, 6876 3' splice site selection Adenine phosphoribosyltransferase pre- morphogenesis, promotion of, 6876 dicot plant nuclei mRNA a-Agglutinin cell adhesion protein position dependence, 4485 endogenous S. cerevisiae introns, mammalian splicing, intron removal during, 6211 cell surface anchorage and ligand- competition between AGs, 4939 Adenosine deaminase gene binding domains, 2554 scanning, 4939 mouse immunoglobulin superfamily member, N. benthamiana nuclei stable transcription arrest site in first 2554 position dependence, 4485 intron, 2718 Albumin/al-fetoprotein intergenic enhancer 5' external transcribed spacer Adenosine deaminase locus chromatin-hypersensitive domains, de- Xenopus precursor rRNA mouse velopmentally regulated, 1619 U3 snRNP-requiring processing event, replication initiation sequence, 5931 Aldolase A gene 5990 Adenovirus human 5' splice site selection alternative poly(A) site use during infec- muscle-specific promoter, 9 plant nuclei, 1323 tion opportunistic promoter, 9 5'-3' exonuclease poly(A) site processing factor, de- ubiquitous promoter, 9 S. cerevisiae crease in activity of, 2411 rat in vitro recombination, requirement ElA skeletal muscle-specific induction, in, 3125 myogenesis inhibition, mediation of, 6469 5'-*3' exonuclease 1, cells lacking 4714 al protein S. cerevisiae Ela product, larger S. cerevisiae mRNA species, 4826 ATF cellular transcription factor fam- DNA sequence requirements for activ- 5S rRNA ily, mediation of transcriptional ity of, 6866 X. laevis oocytes activation by, 561 al-acid glycoprotein gene, rat structural requirements, 6819 ElA protein transcriptional activation 18S rRNA E2F-protein complexes, binding to synergism between nuclear factor for S. cerevisiae and dissociation of, 7267 interleukin-6 and glucocorticoid snR30 small nucleolar RNA required ElA protein, separate domains of receptor, 1854 for synthesis, 2469 E2F complex disruption, roles in, 7029 a1-Fetoprotein gene promoter 87A7 heat E4 protein chromatin-hypersensitive domains, de- shock locus E2F1 gene, regulation of, 6314 velopmentally regulated, 1619 D. melanogaster Adenovirus type 5 (x2 protein topoisomerase II redistribution, 7522 RNA polymerase III transcription of hu- S. cerevisiae man Alu repetitive elements, activa- transcription, repression of, 4029 Abelson murine leukemia virus tion of, 3231 Alpha satellite repeat unit variants c-myc, addition of constitutive expres- Adenovirus type 12 human sion of fragile site, inducible recombination events, localization of, change of transformed-cell phenotype artificial U2 locus, insertion of, 6064 6520 from pre-B-cell lymphomas to Adenovirus vector a-Mating type locus plasmacytomas, 2578 deletion mutant, correction of, 918 C. neofonnans c-ABL gene Adenylyl cyclase peptide pheromone gene, 1962 oncogenic activation S. cerevisiae ae gene last-exon mutation, 4967 antibody mimicking action of RAS chicken Acetylcholine receptor 8-subunit gene proteins, 769 developmental regulation, 4632 activation and repression during myo- RAS proteins, action of, 769 a-specific genes genesis ADH2 gene S. cerevisiae E box, mediation by, 5133 S. cerevisiae transcription, 6866 achaete proneural gene REG1, repression of expression by, Alu repeats D. melanogaster 4391 human helix-loop-helix proteins, regulation Adipocytes methylation, 4523 by, 3514 rat Alu repetitive elements Activation domain determination and differentiation, as- human sociation of ADD1 with, 4753 adenovirus type 5, activation of RNA Egr-1 protein, 4556 ADP/ATP carrier polymerase III transcription by, Acute myeloid leukemia 32-kilodalton receptor for a myristylated 3231 mouse Src peptide but not for pp6Orc poly- transgenic mice E2A-Pbxl t(1;9) translocation protein peptide, 3084 keratin 18 gene, transcriptional insula- of human pre-B-cell acute lym- ADR1 protein tion of, 6742 phocytic leukemia, 351 S. cerevisiae Alu RNA Acute-phase response factor phosphorylation, 4391 small cytoplasmic interleukin-6, activation at posttransla- 13-Adrenergic agonists multiple dispersed loci, production by, tional level by, 276 enhanced response to 4233 ADA3 gene intact SH2 domain, 2391 5-Aminolevulinate synthase S. cerevisiae protein kinase C phosphorylation differentiating MEL cells ADA2 gene, similarity to, 5981 sites, 2391 heme synthesis induction, role in, GAL4-VP16 resistance, 5981 c-src, cells overexpressing, 2391 7122 xii VOL. 13, 1993 SUBJECI INDEX xiii

AML-1 protein Ascites cells, Ehrlich B-cell-specific 3' enhancer human early-S-phase replicons immunoglobulin heavy chain locus DNA binding, sequence specific, 6336 activation, 5020 ax constant region, 1547 runt homology domain, 6336 Asparagine synthetase gene bcl-2 AML-1/ETO protein expression, amino acid regulation of 5' untranslated region human cis- and trans-acting elements, 3202 negative regulatory element, 3686 DNA binding, sequence specific, 6336 Aspergillus nidulans ectopic expression runt homology domain, 6336 microtubule function block of Myc-mediated apoptosis, AMPD1 gene a-tubulin isogene products, 4465 2432 myocytes, expression in, 5854 a-tubulin isogene products Bcl-2 protein Androgen receptor microtubule function, 4465 mechanism controlling cell death, 7000 Reifenstein syndrome Astrocytoma cells BCL2 proto-oncogene D box, mutation in, 7850 human yeast artificial chromosomes, contained Androgen-specific gene activation transformed phenotype, reversion of, in magnitude, 6326 7203 expression, 5469 stringency, 6326 Bcl-3 Angiotensin-converting enzyme (ACE) Ataxia telangiectasia cells NF-KB p50 and p52, interaction with, sperm-specific expression RPA phosphorylation response, radia- 3557 91-base-pair promoter containing tion induced nuclear IKB-like molecule, encoding of, CRE-like element, 18 different from normal human cells, 3557 Animal cells 7222 Bcr-Abl oncoproteins v-Myb and c-Myb transcriptional activa- ATF cellular transcription factors transforming function tion Ela larger product Bcr oligomerization domain, require- S. cerevisiae, comparison with, 4423 direct association with, 561 ment for, 7587 Anterior pituitary-derived cell lines mediation of transcriptional activation Bcr protein rat by, 561 coiled-coil oligomerization domain C-type natriuretic peptide gene pro- ATF family proteins Bcr-Abl transforming function, essen- moter, 4077 cAMP independent tial for, 7587 Antisense rescue NF-KB, interactions with, 7180 K cells c-Fos E-selectin promoter activation, func- pancreas functional domains, 3821 tion in, 7180 cell line isolation technique, 4223 AP-1 activity atp promoter, mitochondrial preneoplastic foci, cultured from, 4223 glucocorticoid receptor, inhibition by maize, 7232 Beta interferon Fos, preferential targeting of, 3782 atpB mRNA spontaneously produced, action of AP-1 transcription factors C. reinhardtii chloroplast autoinduction mechanism, 2846 CC10 gene, regulation of, 3860 3' end maturation is a two-step proc- embryonal carcinoma cells, differenti- AP-1-binding elements ess, 2277 ation of, 2846 protein phosphatase 2A AUF1 protein Beta interferon mRNA potentiation of promoters, 2104 RNA binding, 7652 human AP-1/NF-E2 Autocrine transformation translational regulation, 3487 e-globin promoter transcription, require- 1-like globin gene, embryonic ment for, 911 reversion human AP-2 gene dominant negative platelet-derived developmental regulation, 7457 alternatively spliced mRNA, 4174 growth factor mutant, 4066 Bidirectional DNA replication origin Apolipoprotein B gene reducer Autonomous replication mouse human bacterial DNA sequences adenosine deaminase loci, episomally hepatocyte nuclear factor 3, blocking multimers of, in human cells, 2688 amplified, 2971 of transcriptional activation by, human DNA sequences native locus, 2971 1534 multimers of, in human cells, 2688 Biliary glycoprotein gene Apolipoprotein B mRNA Autonomously replicating sequences human RNA editing, 7288 S. cerevisiae family of novel alternatively spliced Apoptosis chromosome VI, 5043 RNAs, 1273 human lymphocytes Avian fibroblasts Bombyx mon y-irradiation induced, 4875 transformation pentanucleotide telomeric sequence ubiquitin pathway, 4875 v-Myc nuclear overproduction and (TTAGG)n, 1424 Myc, mediation by excess over Max not required, Bone Bcl-2, block by ectopic expression of, 3623 COLlA1-chloramphenicol acetyltrans- 2432 Avian sarcoma virus CI10 ferase fusion genes, transgenic Arginine metabolism regulation fibroblasts, transformed expression of, 5168 S. cerevisiae v-Crk and paxillin, interaction be- Bovine MCM1, role of, 2586 tween, 4648 Arnt coregulator myf5 gene dioxin receptor, DNA recognition by transgenic mice, effect of expression ligand-dependent recruitment, 2504 B-cell development in, 6044 Arrestin gene proximal promoter E2A proteins Bovine papillomavirus mouse complex formation, 7321 E5 protein photoreceptor cells, gene expression expression, 7321 conserved C-terminal domain, 6462 in, 4400 nuclear localization, 7321 PDGF receptor mediation of tumori- retinal factor-binding site, 4400 B-cell differentiation genic transformation, 4137 ARS plasmid pathways BOX DNA S. cerevisiae IL-5 and IL-6, 3929 polyomavirus suppression of segregation bias by B-cell lines embryonal carcinoma cell differentia- DNA polymerase mutation, 1489 V(D)J recombinase inducible, 6223 tion, relationship to, 7747 xiv SUBJECT INDEX MOL. CELL. BIOL.

Breast cancer cells Candida albicans Cdc2 protein kinase T-47D telomeric repeats, unusually large, 551 cyclin-binding regions, 5122 cell cycle progression, changes in, CAP phosphorylation sites, 5122 3577 S. cerevisiae Sucl-binding regions, 5122 cyclin gene expression, regulation of, adenylyl cyclase mutants, 4087 three-dimensional model, 5122 3577 Carcinoma-associated antigen genes CDCS gene BUF protein retroposition, 1507 S. cerevisiae S. cerevisiae Cardiac muscle dbf4, suppressor gene of, 4445 binding, 5749 muscle creatine kinase enhancer activity Cdc7 protein kinase bZIP proteins multiple regulatory elements, differen- S. cerevisiae DNA bending, 5479 tial contributions of, 2753 cell cycle regulation, 2899 Cardiac myosin light-chain gene Dbf4 protein, association with, 2899 C3H 1OT/2 fibroblasts chicken cdc15 mutants p2lras signaling pathway distinct from transcriptional control, mediation of, S. cerevisiae but interdependent with protein ki- 6907 anaphase, arrest in, 4953 nase C pathway, 1471 Cardiac troponin T gene rescue by Xenopus cDNAs, 4953 protein kinase C signaling pathway dis- alternative exon CDC25 tinct from but interdependent with purine-rich positive splicing element, S. cerevisiae p2lras pathway, 1471 3660 Ras, influence of guanine nucleotides C proteins Cardiac/slow-twitch troponin C gene on complex formation with, 1345 phosphorylation human CDC25Mm protein cell cycle regulation, 5762 regulation, 6752 Ras-specific exchange factor, 7718 CACCC box-binding protein Cardiac-specific transcription regulated and constitutive activity, 7718 novel fosljun, repression by Cdc28 ht, gene, encoded by, 5691 myocytes, quiescent and growth-stim- S. cerevisiae CACCC element ulated, 600 Cln3, activation by, 3266 P-globin tissue-specific cis element, targeting Cdc28 protein kinase complexes potential activators, discrimination at, 600 S. cerevisiae among by correlation of binding O-Casein gene promoter mating pheromone signal transduction and transcriptional properties, 44 rat pathway, 5659 DNA-binding proteins, regulation of Cdc68 protein Caenorhabditis elegans S. 3' splice acceptor site interaction with, 7303 cerevisiae Casein kinase I Sanl, antagonism by, 7553 AG not required for splicing, 626 C/EBP hypodermal development HeLa cell nuclear kinase simian virus 40 DNA replication, 1202 basic region residues novel protein tyrosine kinases, expres- DNA sequence recognition, 6919 sion of, 7133 CBFSp S. cerevisiae half-site spacing preference, 6919 kin-15 gene IL-8 gene regulation novel protein tyrosine kinase, encod- centromeres, binding to, 4884 NF-KB, synergism and cooperativity ing of, 7133 microtubules, binding to, 4884 with, 7191 kin-16 gene CC10 gene rat glutathione S-transferase Ya gene novel protein tyrosine kinase, encod- transcription factors, regulation by xenobiotic response element func- ing of, 7133 AP-1 family, 3860 tion, regulation of, 4365 myosin light chain gene HNF-3 family, 3860 C/EBP family transposon Tcl, site-selected insertion octamer family, 3860 MIP-lot gene, transcriptional regulation of, 902 "C-C"-type cytokine of, 5276 ubc-2 gene fic gene product, 2020 NF-KB family members, association with ubiquitin-conjugating enzyme involved CCAAT transcription factor/nuclear factor Rel domain-bZIP interaction, 3964 in selective protein degradation, 1-dependent promoters Cell cycle 1371 Myc overexpression, suppression by, murine erythroleukemia cells Calcitonin/calcitonin gene-related peptide 3093 p53-induced cell death, 711 enhancer CD4 regulation retinoic acid repression of activation human c-Myc transcriptional activation do- by HLH-octamer complex, 6079 transgenic mice, tissue-specific expres- main, 4125 pre-mRNA processing sion in, 2952 S phase intron and exon elements, control by, CD4 enhancer p64 in nucleus, presence of, 6147 5999 HEB-E12-related protein heterodimer Cell cycle blockage interactions with, 5620 S. cerevisiae Calcium levels, intracellular heat shock mediated, 1034 elevated regulation of activity by HEB-E12-re- lated heterodimer, 5620 Cell cycle control c-Yes, inactivation of, 7507 protein p53-mediated cell death, 1415 Calcium-binding proteins CD8at gene Cell death epidermal human Bcl-2-controlled mechanism profilaggrin, 613 last intron, enhancer in, 7056 macromolecular synthesis, no require- Calmodulin CD45 tyrosine protein phosphatase ment for, 7000 S. cerevisiae Afn tyrosine protein kinase Myc, no requirement for, 7000 essential mitotic target, 7913 tyrosine phosphorylation, 1651 murine erythroleukemia cells Calmodulin gene Ick tyrosine protein kinase p53 induction, 711 T. brucei tyrosine phosphorylation, 1651 p53 mediation of EF-hand 5 protein and ubiquitin ex- c-src tyrosine protein kinase cell cycle control, relationship to, 1415 tension protein 52 genes, genomic tyrosine phosphorylation, 1651 Cell motility and transcriptional linkage with, cdc2 kinase rho GDI, 72 207 cyclin A, activation by, 1194 rho p21, 72 VOL. 13, 1993 SUBJECT INDEX xv

rho p21 inhibitory GDP/GTP exchange Chimeric VP16-estrogen receptor Chromosome stability protein, 72 S. cerevisiae replication origins, effect of deletion of, Cell transformation cell growth arrest, 462 391 pp60v-s estradiol-inducible squelching, 462 Cig2 and Cdc13 B-type cyclins GAP, role of, 6799 PDRJ allele, suppression of effects by, S. pombe Cellular adhesion 462 mitosis, different functions in, 2286 phorbol ester induced a2-Chimerin Clathrin-deficient strains NF-KB competitive binding, inhibition selective expression S. cerevisiae by, 6530 brain regions, 4986 overexpression of ubiquitin, rescue Cellular immediate-early genes testes, 4986 by, 521 lungs, regulation of expression in, 3213 Chinese hamster ovary cells CLEO element Centromeres dihydrofolate reductase locus GM-CSF promoter function second-site suppressors, 5085 binding factors, recognition by, 7399 genetic dissection, 3156 splicing mutants, 5085 induction signals, mediation of, 7399 S. pombe mutant CLN2 variability, 4578 sterol-regulated genes, 5175 S. cerevisiae Centromeric heterochromatin Chipmunk FARI, posttranscriptional regulation human hibernation-associated gene regulation, by, 1013 structural characteristics, higher or- 1516 mating pheromone, expression in re- der, 6520 Chironomus, members of genus sponse to, 1013 CH41 promoter telomere-associated repeat units, com- Cln3 S. cerevisiae plex S. cerevisiae regulatory element, 7604 evolution from sequences similar to Cdc28 activation, 3266 Chaperonin, cytoplasmic simple telomeric repeats, 1583 cmdl-l a- and 1-tubulin folding, requirement Chlamydomonas reinhardtii S. cerevisiae for, 2478 chloroplast atpB mRNA calmodulin mutant, temperature sensi- Chick 3' end maturation is a two-step proc- tive, 1779 neural retina development ess, 2277 suppressor related to fork head family C/EBP-like protein, 331 Chloroplast of DNA-binding proteins, 1779 glucocorticoid hormones, responsive- ribosomal protein L21, nuclear gene COLlA1-chloramphenicol acetyltrans- ness to, 331 coding for ferase fusion genes Chick embryo developmental regulation of a house- bone, transgenic expression in viral gene expression/transduction keeping gene by alternative pro- promoter element utilization, 5168 spatial restriction, 2604 moters, 2614 Colony-stimulating factor 1 Chicken Chloroplast atpB mRNA c-myc and phosphatidylcholine hydroly- as gene C. reinhardtii sis developmental regulation, 4632 3' end maturation is a two-step proc- collaborating mitogenic pathways, cardiac myosin light-chain gene ess, 2277 1522 transcriptional control, mediation of, Chromatin Core-binding factor 6907 enhancer/locus control region, 3990 murine leukemia virus enhancer chromatin assembly inactive subunits, cloning and characterization f-globin DNA signals, effect of, 7596 methylation focus, spread from, 7321 of, 3324 b-crystallin gene Chromatin assembly T-cell receptor enhancer embryo lens, expression in, 3282 chicken subunits, cloning and characterization CTCF nuclear factor, 7612 0-globin DNA signals, effect of, 7596 of, 3324 embryo lens Chromatin condensation COT2 gene b-crystallin gene expression, 3282 dynamics, 7522 S. cerevlsiae ,3-globin DNA signals Chromatin-hypersensitive domains glucose-dependent divalent cation chromatin assembly, influence on, developmentally regulated transport, requirement for, 2041 7596 albumin/al-fetoprotein intergenic en- COUP-TF heat shock transcription factor, novel hancer, 1619 lactoferrin gene heat shock factor 3, 1983 a1-fetoprotein gene promoter, 1619 estrogen receptor-mediated activation, new regulatory pathway, 1983 Chromosomal instability repression of, 1836 histone H5 gene delayed COX3 mRNA transcription, regulation of, 4904 DNA damage, induction by, 6667 S. cerevisiae MyoD protein Chromosomal replication defect, suppression of, 4806 MLC1 gene, action on, 7153 S. cerevisiae CpG island mapping myogenin DNA polymerases 8 and £, require- mouse double-minute chromosome, 4459 MLC1 gene, action on, 7153 ment for, 496 CpG methylation myosin light-chain 1 gene Chromosome 7 V(D)J recombination in transgenic mice, MyoD, action of, 7153 human influence on, 571 myogenin, action of, 7153 indefinite division of fibroblasts, sup- CR2 maxicircle transcripts purine nucleotide synthesis genes pression of, 6036 T. brucei coexpression, 4784 Chromosome break editing, 6832 somatic immunoglobulin gene conver- transfected DNA, integration of Creatine kinase-M gene sion telomere repeat sequences, acquisition directly injected skeletal and cardiac pseudogene donor pool, germ line of, 977 muscle, control in, 1264 maintenance of, 821 Chromosome segregation CREB YB-1 S. cerevisiae protein kinase A phosphorylated liver, expression in, 4186 CSEI and CSE2, 4691 phosphatase 2A, dephosphorylation Chicken embryo Chromosome segregation, mitotic by, 2822 AFAP-110 protein S. cerevisiae stimulus-transcription coupling actin filaments, association with, 7892 PLCl, 4351 rate limitation, 4852 xvi SUBJECT INDEX MOL. CELL. BIOL.

transcriptional stimulation CYC2 gene Cytoplasmic mRNA phosphatase 2A, regulation by, 2822 S. cerevisiae nonsense codons, lack of effect on half- CRE-like element protein product, 6442 life of, 1892 angiotensin-converting enzyme, sperm- Cyclase-associated protein Cytosolic glutathione peroxidase gene specific expression of S. cerevisiae mouse 91-base-pair promoter, 18 adenylyl cyclase mutants, 4087 transcriptional up-regulation, 6290 Crithidia fasciculata Cyclic AMP-dependent protein kinase cDNA, complete, 7766 catalytic (Ca) subunit autoactivation DAD1 protein zinc finger protein threonine 197 phosphorylation, 2332 human kDNA minicircle conserved universal inhibitors cDNA, cloning of, 6367 sequence, binding to, 7766 DNA synthesis inhibition, 4477 dbf4 gene CRK protein Cyclic AMP-dependent protein kinase A S. cerevisiae human regulatory subunit RIox CDCS is suppressor gene, 4445 PC12 cells, neuronal differentiation of, ret tyrosine kinase, fusion with Dbf4 protein 4409 thyroid tumor-specific transforming S. cerevisiae SH2 and SH3 domains, 4409 sequence, 358 Cdc7 protein kinase, association with, c-Crk protein Cyclin A 2899 N-terminal extension human Deletion mutant regulator of binding to Tyr-phospho- cdc2 kinase, activation of, 1194 adenovirus vector, correction by, 918 rylated proteins, 7295 conserved cyclin box, 1194 Developmental control genes Tyr-phosphorylated proteins, binding to Cyclin B2 amino terminus inducible expression system, basis for, N-terminal extension, regulation by, X. laevis 7971 7295 mitotic arrest, 1480 5,6-Dichloro-1-j--D-ribofuranosylbenzimida- v-Crk protein Cyclin Dl zole (DRB) paxillin, interaction with, 4648 elevated levels c-myc transcriptional elongation, use in Crossover increased eIF-4E expression, response studying, 5647 location during gene targeting with inser- to, 7358 Dicot plant nuclei tion and replacement vectors, 2134 Cyclin gene 3' splice site selection Cryphonectria parasitica expression, regulation of position dependence, 4485 mycovirus-induced hypovirulence-asso- T-47D human breast cancer cell cycle Dihydrofolate reductase locus ciated traits progression, changes in, 3577 Chinese hamster ovary cells targeted host gene inactivation, mim- Cyclins, B-type mutants, 5085 icking by, 7782 S. cerevisiae splicing VWr2 gene mitosis and meiosis, differential func- Dihydrofolate reductase minigene targeted inactivation, 7782 tion and expression in, 2113 hamster Cryptococcus neoformans S. pombe direct selection for mutations affecting a-mating type locus Cig2 and Cdc13, 2286 specific splice sites, 289 peptide pheromone gene, 1962 mitosis, different functions in, 2286 Dihydrofolate reductase pre-mRNA aB-Crystallin Cyclosporin A endogenous mouse NIH 3T3 fibroblasts interleukin-2 gene, inhibition of inducible splicing, intron removal during, 6211 glucocorticoid responsiveness, 1824 activity of Dihydrofolate reductase promoter thermal protection, involvement in, noncanonical octamer-binding site, growth regulation 1824 1155 correlation with protein synthesis-de- 81-Crystallin enhancer signal transduction inhibition pendent increase in E2F1 mRNA, lens-specific activity immunophilins, mediation by, 4760 1610 regulatory elements, 5206 Cytochrome b Dimerization, leucine zipper mediated 8-Crystallin gene transcripts met receptor tyrosine kinase chicken embryo lens, expression in, S. cerevisiae mitochondria, CBP1-de- oncogenic potential, activation of, 3282 pendent accumulation in, 4203 6711 aB-Crystallin/small heat shock protein en- Cytochrome c Dioxin receptor hancer S. cerevisiae DNA recognition mouse mitochondrial import, 6442 Arnt coregulator, ligand-dependent control elements, 7144 Cytochrome P-450LA1 recruitment of, 2504 CSE1 gene expression, induction of mediation of induction of cytochrome S. cerevisiae mediation by dioxin receptor by pro- P-450IA1 expression, 677 chromosome segregation, 4691 tein kinase C-dependent mecha- rat glutathione S-transferase Ya gene CSE2 gene nism, 677 xenobiotic response element func- S. cerevisiae Cytokine LD78 gene promoter tion, regulation of, 4365 chromosome segregation, 4691 human signal transduction pathways CT elements binding of transcriptional factors to cross-coupling, 677 zinc finger proteins, bound by negative regulatory element, 2787 D-loop region human c-myc promoter activities, con- Cytokine receptors mitochondrial DNA trol of, 5710 erythropoietin receptor inactivation single termination-associated se- CTCF nuclear factor point mutations in regions with homol- quence, protein binding to, 2162 chicken, 7612 ogy with other cytokine recep- DNA bending C-type natriuretic peptide gene promoter tors, 1788 bZIP proteins, 5479 rat Cytomegalovirus, human retinoid receptor complexes, 6509 anterior pituitary-derived cell lines, major immediate-early proteins thyroid hormone receptor complexes, 4077 transcriptional activation mediated by, 6509 CYCl mRNA 1238 DNA binding S. cerevisiae Cytoplasmic inheritance NFKB1 selective signals that produce 3' termini, 7836 P. falciparum, 7349 acquisition, 3850 VOL. 13, 1993 SUBJECT INDEX xvii

DNA breakage tric point of, 217 D-Raf UVB induced dopa decarboxylase gene terminal signal transduction during c-fos transcriptional induction, inter- splicing, alternative, 4549 embryogenesis, 1163 ference with, 6992 dunce gene ribosomal protein S6 gene DNA damage human dunce-like phosphodiesterase mutations causing tissue overgrowth, delayed chromosomal instability, induc- genes, homology to, 6558 2524 tion of, 6667 ecdysone-inducible genes RNA polymerase II DNA polymerase ecdysone regulation, complexity of, two large subunits, mutations in genes S. cerevisiae 7101 encoding, 4214 8 and £ required for chromosomal rep- ecdysone-responsive sites rRNA genes lication, 496 ribonucleoprotein complex, unique, phorbol ester and serum, stimulation DNA polymerase a 5323 by, 934 human embryogenesis rRNA transcription, in vivo regulation of simian virus 40 large T antigen, inter- Hsp83 RNA localization, 3773 phorbol ester and serum, response to, action with, 809 Enhancer ofzeste gene 928 DNA polymerase mutation trithorax, partial similarity to, 6357 s36 chorion gene S. cerevisiae erect wing gene oogenesis, follicular expression dur- segregation bias of ARS plasmid, sup- encoding of protein similar to sea ur- ing, 5898 pression of, 1489 chin P3A2 protein, 3641 Sex-lethal gene DNA polymerases a, 8, and £ even-skipped protein autoregulation, 7734 S. cerevisiae correlation of cooperative binding at a Sex-lethal male exon DNA repair synthesis during base ex- distance with repression, 2742 regulated splicing involving blockage cision repair, influence on each silencing, mechanism of, 2742 mechanism, 1408 other during, 1051 fushi tarazu homeoprotein N-terminal short intron, splicing of DNA repair defect domain species-specific signals, 1104 double-strand break synergistic activation of transcription, sperm tail proteins, conserved V(D)J recombination, 3464 1599 gene duplication, translational regula- DNA replication fushi tarazu proximal enhancer tion of, 1708 D. melanogaster proteins, interactions with, 5549 Staufen histone gene repeats, 4098 GAGA transcription factor, cDNAs en- relatedness to human immunodefi- initiation coding, 7961 ciency virus type 1 TAR RNA- human rRNA genes, 6600 hairy gene binding protein TRBP, 2193 S. cerevisiae rat gene with sequence homology, 105 tissue culture cells p60" expression, effect of, 5112 heat shock factor histone gene repeats, DNA replication simian virus 40 activation, 3481 of, 4098 HeLa cell nuclear kinase casein kinase heldup3 mutant topoisomerase II I, 1202 abnormal muscle development caused 87A7 heat shock locus, redistribution termination by splicing defect affecting se- in, 7522 human rRNA genes, 6600 lected troponin I isoforms, 1433 Torso DNA synthesis muscle development, abnormal, 1433 terminal signal transduction during thyrotropin stimulated troponin I, splicing defect affecting, embryogenesis, 1163 inhibition, 4477 1433 transcription DNA topoisomerase I helix-loop-helix proteins instantaneous heat shock, effect of, S. cerevisiae achaete proneural gene, regulation of, 3456 DNA topology, 6702 3514 troponin I, splicing defect affecting, 1433 promoter activation, 6702 histone gene repeats Ul snRNA gene DNA topoisomerase II mutants DNA replication, 4098 transcription in vitro, requirements S. cerevisiae hsp26 for, 5918 meiosis-specific arrest, 3445 chromatin structure, 2802 Ultrabithorax homeodomain protein DNA-damaging agents (CT)n * (GA),, repeats and heat shock DNA binding, cooperative, 6941 p53 cellular activity, induction of, 4242 elements, distinct roles of, 2802 DRS1 to DRS7 genes dopa decarboxylase gene transcriptional activation, 2802 S. cerevisiae D. melanogaster I factor long interspersed nuclear ele- ribosome assembly and function, re- splicing, alternative, 4549 ment-like retrotransposon quired for, 7901 Double-minute chromosome internal promoter and sequences that dunce gene mouse regulate expression, 1042 D. melanogaster CpG island mapping, 4459 insertions human dunce-like phosphodiesterase Double-stranded RNA P-element-induced gene conversion, genes, to, 6558 interferon-stimulated response element- 7006 homology binding factors, activation of, 3756 instantaneous heat shock dunce-like phosphodiesterase genes Drosophila melanogaster transcription, effect on, 3456 human 85-kDa TFIID subunit, 7859 muscle development, abnormal, 1433 D. melanogaster dunce gene, homol- 87A7 heat shock locus nonAdiss protein ogy to, 6558 topoisomerase II redistribution, 7522 NonO, homolog of, 5593 dunce-like phosphodiesterases achaete proneural gene oogenesis human helix-loop-helix proteins, regulation Hsp83 RNA localization, 3773 antidepressant drugs, potential targets by, 3514 s36 chorion gene, follicular expression for, 6558 deletions of, 5898 P-element-induced gene conversion, Pig-1 and Sgs-4 genes ElA 7006 transcriptional switch, 184 adenovirus developmental mutant quartet pre-mRNA 5' splice site selection E2F-protein complexes, binding to bovine smg p25a GDP dissociation AU-rich intronic elements, effect of, and dissociation of, 7267 inhibitor homolog, shift in isoelec- 7689 larger product xviii SUBJECT INDEX MOL. CELL. BIOL.

ATF cellular transcription factor fam- E7 protein F9 ily, direct association with, 561 human papillomavirus type 16 histone gene demethylation, 5538 ATF cellular transcription factor, me- E2F-cyclin A complex, association MHC class I genes diation of transcriptional activa- with, 6537 retinoic acid induction, 6157 tion by, 561 retinoblastoma gene product E2F, in- mouse myogenesis inhibition, mediation of teraction with, 953 LINE-1 RNA and protein, expression E1A12s-basic helix-loop-helix protein E2-2 of, 5383 interaction, correlation with, 4714 B-cell-specific E2-box DNA-binding pro- Embryonic carcinoma x fibroblast somatic ElA protein tein, subunit of, 3522 cell hybrids adenovirus E box Oct-3/4 gene E2F complex disruption, roles of sep- mediation of acetylcholine receptor chromatin structure, 891 arate domains in, 7029 b-subunit gene activation and re- extinction, 891 E2A pression, 5133 methylation status, 891 B-cell-specific E2-box DNA-binding pro- EAP cellular RNA-binding protein transcriptional activity, 891 tein, subunit of, 3522 EBER 1, recognition of conserved stem- Embryonic stem cells E2A proteins loop in, 703 differentiation B-cell development Early meiotic upstream activation se- hematopoietic commitment, 473 complex formation, 7321 quence interferon responsiveness expression, 7321 S. cerevisiae inducible expression system, basis for, nuclear localization, 7321 bipartite structure, 2172 7971 E2A-Pbxl t(1;9) translocation protein Early-B-cell factor mouse human pre-B-cell acute lymphocytic leu- DNA-binding specificity, 3392 gene-targeting tag and exchange, 4115 kemia purification, 3392 site-directed point mutations, 4115 mouse acute myeloid leukemia, cause EBER 1 small RNA EMSI gene product of, 351 Epstein-Barr virus human E2F recognition of conserved stem-loop by carcinomas, amplification and overex- cell cycle analysis EAP, 703 pression in, 2891 primary human T cells, 3975 EBER 2 gene cell-substratum contact sites, location DNA-binding activity Epstein-Barr virus in, 2891 suppression by IFNs and IL-6, 5255 exclusive RNA polymerase III tran- v-src substrate, homology to, 2891 family of transcription factors scription, importance of upstream Endomembrane system basal promoter element for, 2655 higher plants retinoblastoma protein, binding to, Ecdysone-inducible genes small heat shock proteins, 238 7813 D. melanogaster Endoplasmic reticulum, unfolded proteins protein complexes ecdysone regulation, complexity of, in ElA, binding to and disruption by, 7101 S. cerevisiae 7267 Ecdysone-responsive sites KAR2 (BiP) gene promoter region, retinoblastoma gene product D. melanogaster response of, 877 human papillomavirus type 16 E7 pro- ribonucleoprotein complex, unique, Enhancer factor C tein, interaction with, 953 5323 RFX1, identity with, 6375 retinoblastoma gene product, interaction EF-hand 5 protein gene Enhancer ofzeste gene with, 3384 T. brucei D. melanogaster E2F-1 calmodulin and ubiquitin extension trithorax, partial similarity to, 6357 retinoblastoma protein, direct binding to protein 52 genes, genomic and Enhancer/locus control region transactivation, inhibition of, 6501 transcriptional linkage with, 207 chromatin, 3990 E2F1 gene Egr-1 protein EN02 regulation by Rb, p107, and adenovirus activation domain, 4556 S. cerevisiae E4, 6314 nuclear localization signal, bipartite, GCR1-dependent transcriptional acti- E2F1 mRNA 4556 vation, complex regulatory ele- protein synthesis-dependent increase repression module, 4556 ment modulating, 2623 correlation with growth regulation of Ehrlich ascites cells Epidermal growth factor dihydrofolate reductase promoter, early-S-phase replicons ERK2 phosphorylation, induction of, 1610 activation, 5020 7248 E2F-2 protein eIF-2 p2lras, guanine nucleotide exchange rate E2F-like properties, 7802 S. cerevisiae on E4 protein GCD6 and GCD7 are subunits of gua- fibroblasts, regulation in, 1903 adenovirus nine nucleotide exchange factor, Ras activation 1920 p21ras, enhanced exchange of guanine E2F1 gene, regulation of, 6314 eIF-2 y subunit nucleotides on, 155 E4TF1 transcription factor S. cerevisiae Epidermal growth factor receptor Ets and Notch motifs GCD11, 506 mouse Grb2 protein, interaction with, cDNA cloning of subunits with, 1385 Elmlp protein 5500 E5 protein S. cerevisiae Epidermal growth factor-Elk receptor ty- bovine papillomavirus dimorphism regulation, involvement rosine kinase conserved C-terminal domain, 6462 in, 5567 chimeric PDGF receptor mediation of tumori- Embryogenesis biological and biochemical activities, genic transformation, 4137 X. laevis 7071 E6-AP axis formation, modulation of, 7540 epsI5 p53 interaction with human papillomavi- Embryonal carcinoma cells transforming activity, 5814 rus E6 oncoprotein, mediation of, differentiation Epstein-Barr virus 775 BOX DNA, relationship to, 7747 EBER 1 small RNA regions directing HPV E6 interactions spontaneously produced beta inter- recognition of conserved stem-loop by with p53, 4918 feron, action of, 2846 EAP, 703 VOL. 13, 1993 SUBJECT INDEX xix

EBER 2 gene tors, 1788 Farl protein exclusive RNA polymerase III tran- Erythropoietin receptor gene S. cerevisiae scription, importance of upstream mouse mating pheromone signal transduction basal promoter element for, 2655 upstream repetitive element, transcrip- pathway, 5659 ZEBRA activation domain tional inhibition by, 98 Farnesyltransferase mechanism of action, 7045 Estrogen receptor S. cerevisiae, 4260 modular organization, 7045 lactoferrin gene activation Fc,y receptor gene Erb A COUP-TF, repression by, 1836 human nuclear hormone receptor Estrogen-responsive gene IFN regulatory mechanism, novel, amino acids outside zinc finger do- retinoid X receptor ,B, activation by 2182 main, 2366 multiple inhibitory pathways, 2258 IFN-,y, activation by, 2182 neoplasia, 2366 Ets myeloid-cell-specific expression, 2182 novel DNA sequence specificity, 2366 cis-acting sequences FcRF-y c-ErbA mediation of megakaryocyte-specific gamma interferon, activation by C-terminal sequence deleted in v-ErbA expression, 668 membrane-associated tyrosine kinase, activities, essential for, 3675 c-Ets family requirement for, 3984 erbA oncogene MIP-la gene, transcriptional regulation vanadate, mimicking by, 3984 RAR action, repression of, 5970 of, 5276 K-fgf RXR action, repression of, 5970 Ets and Notch motifs retrovirus, carried by v-ErbA E4TF1 subunits with, cloning of, 1385 diffuse meningeal tumors, induction deleted C-terminal sequence Ets protein of, 1998 c-ErbA activities, essential for, 3675 mouse terminal deoxynucleotidyltrans- soft-tissue fibrosarcomas, induction of, ERCCS gene ferase gene 1998 human interaction with critical promoter ele- ,B fibrinogen promoter S. cerevisiae RAD2, homology to, ment in, 2982 hepatocyte nuclear factor 1-dependent 6393 Ets proteins interleukin-6-responsive element, S. pombe radl3, homology to, 6393 Ig heavy-chain gene expression, regula- 1183 erect wing gene tion of, 7163 Fibroblast cell lines D. melanogaster Eukaryotic initiation factor 4E indefinite division encoding of protein similar to sea ur- expression, increased chromosome 7, suppression by, 6036 chin P3A2 protein, 3641 cyclin Dl levels, effect on, 7358 Fibroblast growth factor ERK1 protein kinase Eukaryotic translation initiation factor 2 MRF4 activity, inhibition of, 5943 extracellular signal regulated S. cerevisiae receptor kinase TALl oncoprotein, phosphorylation GCN1 required for phosphorylation by signal transduction, 3907 of, 801 GCN2, 3541 Fibroblast growth factor 3 erp gene guanine nucleotide exchange factor, Golgi complex, retention in ERP nontransmembrane protein tyrosine 4618 FGF3 export from cells, effect on, phosphatase, encoding of, 5195 Eukaryotic translation initiation factor 4A 5781 structure, mapping, and expression, 5195 HRIGRXXR region Fibroblast growth factor family ERP protein ATP hydrolysis, required for, 6789 human cell growth, effect on, 5195 RNA binding, required for, 6789 ninth member, novel cDNA encoding, Erythroblasts even-skzpped protein 4251 PU.1, immortalization by, 5670 D. melanogaster Fibroblast growth factor receptor 2 Erythroid Kriippel-like factor correlation of cooperative binding at a pre-mRNA mouse distance with repression, 2742 alternative splicing, 5461 CACCC element, binding to, 2776 silencing, mechanism of, 2742 Fibroblast growth factor receptor 2 pre- Krappel family nuclear proteins, rela- Evi-I gene mRNA tionship to, 2776 mouse human Erythroleukemia cells zinc fingers, 4291 alternative splicing, 5461 Friend virus transformation Ewing's sarcoma Fibroblast growth factor receptor kinase p53 protein, growth suppression by, EWS/FLI-1 fusion gene signal transduction, 3907 1456 FLI-I, comparison with, 7393 Fibroblasts mouse EWSIFLI-1 fusion gene Flk2/Flt3 receptor tyrosine kinase CAAT box, binding of novel factor to, Ewing's sarcoma mitogenic signaling, 6572 6969 FLI-I, comparison with, 7393 substrate specificity, 6572 differentiation arrest, 5582 Exon switching p2l s, guanine nucleotide exchange rate erythroid differentiation, 1093 rat prostate epithelial cells, 4513 on 3-globin promoter activation, 6969 Extracellular signal-regulated kinase 2 epidermal growth factor, regulation 1maj globin promoter, 1093 phosphorylation by, 1903 3-globin promoter-binding factor, 4311 induction 7248 Fibronectin gene heme synthesis, induction of, 7122 EGF, by, rat p53-induced cell death, 711 alternatively spliced exon, regulation stromal cell-independent growth, 5582 F9 embryonal carcinoma cells of, 5301 terminal differentiation, blocking of, histone gene demethylation, 5538 fic 3505 a-Factor receptor "C-C"-type cytokine, 2020 Erythropoietin receptor S. cerevisiae FK506 Friend spleen focus-forming virus gpS5 adaptation, promotion of, 6876 S. cerevisiae glycoprotein, fusion with morphogenesis, promotion of, 6876 amino acid import inhibition, 5010 factor-dependent hematopoietic cell FARI signal transduction inhibition line, transformation of, 739 S. cerevisiae immunophilins, mediation by, 4760 inactivation CLN2 gene expression in response to Flesh fly point mutations in regions with homol- mating pheromone, posttranscrip- 59-kilodalton protein ogy with other cytokine recep- tional regulation of, 1013 characterization, 4049 xx SUBJECT INDEX MOL. CELL. BIOL.

defense protein gene NF-KB-binding Friend virus-transformed erythroleukemia vation of motifs, binding to, 4049 cells tyrosine phosphatase/kinase signaling purification, 4049 p53 protein, growth suppression by cascade, 1634 Flk2/Flt3 receptor tyrosine kinase erythropoietin, sensitivity to, 1456 Gamma interferon activation factor mitogenic signaling, 6572 hemoglobin production, 1456 gamma interferon, activation by substrate specificity, 6572 fipl+ gene tyrosine phosphatase/kinase signaling FLP recombinase S. pombe cascade, 1634 S. cerevisiae ferric iron uptake, required for, 4342 response cleavage and ligation, mechanism of, gp9l-phox subunit of human NADPH developmental control in cells of mac- 3167 phagocyte oxidoreductase gene, rophage lineage, 3245 mutations, classification of, 3167 homology to, 4342 Gas6 protein c-fims Fus3 protein vitamin K-dependent proteins, member mouse S. cerevisiae of mRNA expression, control of, 3191 mating pheromone signal transduction protein S, relation to, 4976 Focal adhesion-associated protein tyrosine pathway, 5659 GATA kinase fushi tarazu homeoprotein N-terminal do- cis-acting sequences pp125FAK main mediation of megakaryocyte-specific noncatalytic domain, autonomous D. melanogaster expression, 668 expression of, 785 synergistic activation of transcription, GATA-1 fork head family of DNA-binding proteins 1599 a-globin promoter transcription, require- S. cerevisiae fushi tarazu proximal enhancer ment for, 911 cmdl-l suppressor, 1779 D. melanogaster U. maydis urbsl gene product, similarity Fos proteins, interactions with, 5549 to, 7091 glucocorticoid receptor inhibition of fyn tyrosine protein kinase GATA-4 AP-1 activity, preferential target of, CD45 tyrosine protein phosphatase mouse 3782 tyrosine phosphorylation, 1651 endodermally derived tissues and c-Fos heart, 2235 functional domains G1 cyclin expression retinoic acid-inducible, GATA-binding antisense rescue, 3821 S. cerevisiae transcription factor, 2235 c-fos gene heat shock mediated, 1034 GATA family transcription factors Ras-cAMP pathway, connection with, DNA-binding specificities, 3999, 4011 mRNA 6274 destabilizing elements in coding re- G1/S-specific transcription Gax gene gion, 5034 S. cerevisiae rat transcriptional induction SWI4/SWI6 protein complex, 1069 vascular smooth muscle cells, down- UVB-induced DNA breaks, interfer- G protein subunits regulation in, 3722 ence due to, 6992 S. cerevisiae G/C box-binding transcription factor, novel Fos protein mating, interactions involved in, 1 Wnt-l-inducing factor-1 ornithine decarboxylase gene, direct gaddl53 gene Wnt-I expression during neuroectoder- transcriptional stimulation of PC12 glucose deprivation, regulation by, 4736 mal differentiation, regulation of, cells, 4657 GAGA transcription factor 1590 ornithine decarboxylase gene, lack of D. melanogaster GCD6 and GCD7 direct transcriptional stimulation of cDNAs, 7961 S. cerevisiae fibroblasts, 4657 GAL4 gene eIF-2 guanine nucleotide exchange Fos proteins S. cerevisiae factor, subunits of, 1920 transformation weak expression, promoter elements GCN4, translational regulation of, transactivation domain, requirement determining, 4999 1920 for, 7429 GAL4-VP16 protein GCD11 /FosB initiator-associated transcription, media- S. cerevisiae quiescent Rat-lA cells, proliferative acti- tion of, 7469 eIF-2 y subunit, 506 vation of, 4157 Gal80 protein GCN4 expression, negative regulator FosB proto-oncogene K lactis of, 506 regulatory function required for transfor- galactose regulon, glucose repression GCN1 mation encoded by amino terminus, of, 7566 S. cerevisiae 2635 S. cerevisiae Gal80, conservation eukaryotic translation initiation factor fos/jun with, 7566 2 phosphorylation, required for, cardiac-specific transcription, repression S. cerevisiae 3541 of galactose regulon, glucose repression GCN2 protein kinase myocytes, quiescent and growth-stim- of, 7566 S. cerevisiae ulated, 600 K lactis Gal80, conservation with, activation, 5099 tissue-specific cis element, targeting 7566 GCN4 gene at, 600 GAL genes S. cerevisiae fos/jun family S. cerevisiae GCD6 and GCD7, translational regula- myeloid differentiation, positive regula- TSF3, silencing by, 831 tion by, 1920 tors of, 841 Gal2 gene product GCD11, negative regulation by, 506 Fra-1 transformation gene, 762 translation, stimulation of, 5099 NFAT-1 DNA binding complex, 1911 Gamma interferon GCN4 protein Friend spleen focus-forming virus gp55 FcRFy, activation of S. cerevisiae glycoprotein membrane-associated tyrosine kinase, unusual activation site interspersed erythropoietin receptor, fusion with requirement for, 3984 with complex transcriptional re- factor-dependent hematopoietic cell vanadate, mimicking by, 3984 pression site in Ty2 elements, line, transformation of, 739 gamma interferon activation factor, acti- 2091 VOL. 13, 1993 SUBJECT INDEX xxi

GCR1 gene 1-Globin promoter Granulocyte colony-stimulating factor re- S. cerevisiae human ceptor EN02, 2623 locus control region, activation by, human GCR1 protein 6969 cytoplasmic domain regions needed S. cerevisiae 1maJ globin promoter for proliferation and gene induc- TPI glycolytic gene expression, 543 mouse erythroleukemia cells tion, 2384 GC-rich domains reorganization of protein-DNA com- Granulocyte-macrophage colony-stimulat- mRNA and protein levels, bifunctional plexes, 1093 ing factor effects on, 3588 e-Globin promoter AU-rich noncoding region transforming growth factor 11 expres- enhancer-dependent transcription cotranslational mediation of selective sion, control of, 3588 enhancer-bound AP-1/NF-E2, require- destabilization of short-lived Gene activation ment for, 911 mRNAs, 1971 androgen specific promoter-bound GATA-1, requirement short-lived mRNAs, selective destabi- magnitude, 6326 for, 911 lization of, 1971 stringency, 6326 Globin regulatory element (HS-40) Granulocyte-macrophage colony-stimulat- Gene switching human 42 globin promoter activation, ing factor promoter -y- to ,B-globin 2298 CLEO element serum factors, modulation of develop- Glucagon gene binding factors, recognition by, 7399 mental clock by, 4844 rat induction signals, mediation of, 7399 Gene targeting CREB, transcription by, 7080 Granulocyte-macrophage colony-stimulat- insertion and replacement vectors Glucocorticoid hormones ing factor receptor, human crossover location, 2134 neural retina development, chick BA/F3 pro-B cells, signalling in, 1440 Geranylgeranyltransferase-I C/EBP-like protein, 331 transduction of growth-promoting signals S. cerevisiae, 4260 Glucocorticoid receptor in mouse NIH 3T3 cells, 1440 Gfi-1 gene AP-1 activity, inhibition of grb2 gene novel zinc finger protein, 1759 Fos, preferential targeting of, 3782 mouse progression of rat T cell lymphoma lines human molecular cloning, 5500 to IL-2 independence, 1759 Tr transactivation domain interaction Grb2 protein 3-Globin with basal transcriptional machin- mouse CACCC element ery, 399 EGF and NGF receptors, interactions potential activators, discrimination rat al-acid glycoprotein gene with, 5500 among by correlation of binding synergistic transcriptional activation GRF10 protein and transcriptional properties, 44 with glucocorticoid receptor, 1854 S. cerevisiae pmaj globin Glucose response complex SWI5 protein, cooperative DNA bind- mouse L-type pyruvate kinase gene, 7725 ing with, 5524 Glucose transporter genes transcription termination region, 578 T. brucei Growth arrest 13-Globin DNA signals two distinct families, differential regu- p53 cellular activity, induction of, 4242 chicken lation of, 1146 Growth factors chromatin assembly, influence on, Glucose transporters cyclin gene expression, regulation of 7596 multiple T47D human breast cancer cell cycle 3-Globin DNA-binding protein Bi roles of, 638 progression, changes in, 3577 mouse S. cerevisiae GSPI and GSP2 hematopoietic cells and testis, expres- roles of, 638 S. cerevisiae sion restricted to, 2929 Glutathione inhibitors prp20-1 mutant, genetic suppressors Spi-1PU.1 transcription factor, identi- cellular of, 2152 cal to, 2929 ras expression, down-regulation of, GTPase-activating protein a-Globin gene 4416 cell transformation by pp6ov-sP, role in, rabbit Glutathione S-transferase Ya gene xenobi- 6799 nuclear protein-binding sites, 5439 otic response element NF1 ,3-Globin gene rat differential regulation of cellular activi- human C/EBP, regulation of function by, 4365 ties, 2497 expression, developmental control of, dioxin receptor, regulation of function p2l', interaction with 4836 by, 4365 p2l' effector function, dissociation e-Globin gene Glycosyl-phosphatidylinositol-anchored from, 7311 human proteins SH2 domain developmental regulation, 7457 p56k', interaction with, 6385 in vivo binding properties, 1737 -y-Globin gene p59&fn, interaction with, 6385 GTPase-activating proteins ,B-globin gene, switching to Golgi complex a2-chimerin, 4986 serum factors, modulation of develop- FGF3, retention of GTP-binding proteins mental clock by, 4844 FGF3 export from cells, effect on, S. cerevisiae human 5781 nuclear organization, maintenance of, expression, developmental control of, Granulocyte colony-stimulating factor 2152 4836 myeloid cell differentiation, induction of -y-Globin gene promoter v-myb, block by, 2269 H2TF1 human myeloid cell proliferation, induction of NF-KB plO0 component, 6089 stage selector element, Spl binding to, v-myb, lack of block by, 2269 Hamster 3272 Granulocyte colony-stimulating factor re- dihydrofolate reductase minigene y-Globin genes ceptor direct selection for mutations affecting human human specific splice sites, 289 transgenic mice, developmental regu- cytoplasmic domain, distinct regions sterol-regulated genes lation in, 7636 of, 7774 transcriptional activation, loss of, 5175 xxii SUBJECT INDEX MOL. CELL. BIOL.

HAP1 protein by splicing defect affecting se- HER2/neu receptor human lected troponin I isoforms, 1433 human carcinoma cells Jun DNA binding regulation, residues Helix-loop-helix factor, cell-specific growth, effect on, 2247 essential for, 5370 pro-opiomelanocortin gene truncation produced by alternative Heat shock pituitary expression, 2342 RNA processing, 2247 D. melanogaster Helix-loop-helix proteins Herpes simplex virus dopa decarboxylase gene splicing, ef- basic Vmw65 fect on, 4549 TFEC, 4505 acidic domain, transcriptional activa- Heat shock elements D. melanogaster tion by, 5233 S. cerevisiae achaete proneural gene, regulation of, Heteroduplex DNA HSP70, 5637 3514 S. cerevisiae Heat shock factor Idl formation late in meiotic prophase, D. melanogaster loop region, 7874 373 activation, 3481 rat Heteroduplexes S. pombe ADD1 transcription factor, 4753 S. cerevisiae requirement for growth at normal tem- transcriptional activation motif, new meiotic recombination, detection dur- peratures, 749 functional conservation in yeast and ing, 2324 Heat shock factor 1 mammalian cells, 792 Heterogeneous nuclear ribonucleoprotein heat shock gene transcription, activation Hel-Nl protein Al of human exon skipping and inclusion, modulation DNA-binding activity, acquisition of, specificity, 3494 of, 2993 1392 Hematopoietic cell line, factor dependent Heterogeneous nuclear ribonucleoproteins nuclear localization, 1392 fusion of Friend spleen focus-forming C proteins occurrence in absence of stress, 1392 virus gp55 glycoprotein and erythro- phosphorylation, cell cycle regulation oligomerization, 1392 poietin receptor, transformation by, of, 5762 Heat shock factor 3 739 Hexokinase gene chicken Hematopoietic cell phosphatase K lactis new regulatory pathway, 1983 c-Kit, association with, 3350 RAG1 transcriptional regulation, re- Heat shock gene transcription mouse quired for, 3882 heat shock factor 1, activation by IL-3-induced phosphorylation and mi- HF-lb zinc finger protein DNA-binding activity, acquisition of, togenesis, down-regulation of, rat 1392 7577 myosin light-chain 2 gene, binding to nuclear localization, 1392 IL-3R, association with, 7577 element of, 4432 occurrence in absence of stress, 1392 Hematopoietic cells Hibernation-associated gene regulation oligomerization, 1392 IL-3 dependent plasma proteins with collagen-like do- Heat shock genes Flk2/Flt3 receptor tyrosine kinase, main human 6572 mammalian hibernators, 1516 HSF1 oligomerization, modification, Hematopoietic commitment High-mobility-group box proteins and rapid translocation, 2486 embryonic stem cell differentiation, 473 mouse Heat shock protein 70 Heme oxygenase tsHMG gene, encoded by, 4323 rat myelomonocytic cell lines, induction of High-mobility-group-like protein expression altered by age and diet, expression in T. thermophila 2909 TPA, mediation by, 7881 targeting to micronuclei in cell cycle- Heat shock proteins, small Hepatitis B virus dependent and developmentally higher plants core promoter regulated fashion, 163 endomembrane system, localization hepatocyte-specific expression, 443 HIR1 and HIR2 to, 238 positive and negative regulation, 443 S. cerevisiae Heat shock stress regulatory pathway, enhancer histone gene transcription, genes re- novel RFX1, transactivation by, 6375 quired for, 28 S. cerevisiae genetic element, novel Histone gene repeats cis and trans components, 248 HBV gene product expression, essen- D. melanogaster Heat shock transcription factor tial for, 7476 DNA replication, 4098 human RRE-like properties, 7476 Histone gene transcription DNA-binding activity regulation, 5427 myc family gene activation S. cerevisiae Heat shock transcription factor, novel hepatic carcinogenesis, 659 HIRI and HIR2, 28 chicken Hepatocyte Histone H2A gene heat shock factor 3, 1983 hepatitis B virus core promoter, specific demethylation in F9 embryonal carci- new regulatory pathway, 1983 expression of noma cells, 5538 Heat shock transcription factors 1 and 2 positive and 443 Histone H2A.X gene mouse negative regulation, transcription, regulation of HSP70 heat shock element, interaction Hepatocyte growth factor/scatter factor other replication-linked histone genes, with, 3370 receptor difference of regulation of, 984 trimeric binding site preference, 3370 PI 3-kinase, association with Histone H2B gene HEB-E12-related protein heterodimer binding, recognition motif for, 4600 demethylation in F9 embryonal carci- CD4 enhancer Hepatocyte nuclear factor 1 noma cells, 5538 interactions with, 5620 interleukin-6-responsive element Histone HS gene T cells, regulation of activity in, 5620 i fibrinogen promoter, 1183 chicken HeLa cells Hepatocyte nuclear factor 3 transcription, regulation of, 4904 RNA polymerase II transcription liver-specific transcription HKE1/RAT1 initiation and reinitiation rates, 4572 nuclear factor 1, interactions with, S. cerevisiae heldup3 mutant 2401 exonuclease-encoding XRN1/KEM1 D. melanogaster transcriptional activation by, blocking of gene, homology to, 341 abnormal muscle development caused apolipoprotein B gene reducer, 1534 exoribonuclease activity, protein with, VOL. 13, 1993 SUBJECT INDEX xxiii

341 6520 developmental regulation, 7457 hMEF2C gene Alu repeats ERCC5 cDNA-cosmid complementation, brain-specific transcription factor, 2564 methylation, 4523 6393 skeletal muscle-specific transcription fac- Alu repetitive elements ERCC5 gene tor, 2564 adenovirus type 5, activation of RNA S. cerevisiae RAD2, homology to, HMR locus polymerase III transcription by, 6393 S. cerevisiae 3231 S. pombe radl3, homology to, 6393 silencing, factors affecting, 3919 AML-1 protein Fcy receptor gene HMRE mating-type silencer DNA binding, sequence specific, 6336 IFN regulatory mechanism, novel, S. cerevisiae runt homology domain, 6336 2182 HSP82 heat shock gene, rapidly re- AML-1/ETO protein IFN--y, activation by, 2182 versible, position effect on, 727 DNA binding, sequence specific, 6336 myeloid-cell-specific expression, 2182 HNF-3 transcription factors runt homology domain, 6336 1 fibrinogen promoter CC10 gene, regulation of, 3860 apolipoprotein B gene reducer hepatocyte nuclear factor 1-dependent Homeodomain proteins hepatocyte nuclear factor 3, blocking interleukin-6-responsive element, mouse of transcriptional activation by, 1183 DNA-binding specificity, 2354 1534 fibroblast growth factor family, ninth Hox-4.2 gene astrocytoma cells member of mouse transformed phenotype, reversion of, cytokine cDNA, novel, 4251 retinoic acid response element, up- 7203 fibroblast growth factor receptor 2 pre- stream, 257 BCL2 proto-oncogene mRNA HoxB5 protein yeast artificial chromosomes, expres- alternative splicing, 5461 human sion in, 5469 1-globin gene DNA binding, cooperative, 4609 beta interferon mRNA expression, developmental control of, HRIGRXXR region translational regulation, 3487 4836 eIF-4A 3-like globin gene, embryonic -y-globin gene ATP hydrolysis, required for, 6789 developmental regulation, 7457 expression, developmental control of, RNA binding, required for, 6789 biliary glycoprotein gene 4836 HSF1 family of novel alternatively spliced y-globin gene promoter heat shock gene activation RNAs, 1273 stage selector element, Spl binding to, oligomerization, modification, and carcinoma cells 3272 rapid translocation, 2486 HER2/neu receptor, 2247 -y-globin genes hsp26 cardiac/slow-twitch troponin C gene transgenic mice, developmental regu- D. melanogaster regulation, 6752 lation in, 7636 chromatin structure, 2802 CD4 3-globin promoter (CT)n * (GA)n repeats and heat shock transgenic mice, tissue-specific expres- locus control region, activation by, elements, distinct roles of, 2802 sion in, 2952 6969 transcriptional activation, 2802 CD8a gene glucocorticoid receptor hsp6O last intron, enhancer in, 7056 T transactivation domain interaction mitochondria centromeric heterochromatin with basal transcriptional machin- loss of function in, 3050 structural characteristics, higher or- ery, 399 S. cerevisiae der, 6520 granulocyte colony-stimulating factor mitochondrial function, loss of, 3050 chromosome 7 receptor hsp70 indefinite division of fibroblasts, sup- cytoplasmic domain, distinct regions human pression of, 6036 of, 7774 heat shock transcription factor DNA CRK protein granulocyte colony-stimulating factor binding, regulation of, 5427 PC12 cells, neuronal differentiation of, receptor HSP70 heat shock elements 4409 cytoplasmic domain regions needed S. cerevisiae, 5637 SH2 and SH3 domains, 4409 for proliferation and gene induc- HSP78 gene cyclin A tion, 2384 S. cerevisiae cdc2 kinase, activation of, 1194 granulocyte-macrophage colony-stimulat- Clp family protein, encoding of, 6304 conserved cyclin box, 1194 ing factor receptor HSP82 heat shock gene cytokine LD78 gene promoter BA/F3 pro-B cells, signalling in, 1440 S. cerevisiae binding of transcriptional factors to transduction of growth-promoting sig- HMRE mating-type silencer, rapidly negative regulatory element, 2787 nals in mouse NIH 3T3 cells, reversible position effect of, 727 DADM protein 1440 Hsp83 cDNA, cloning of, 6367 HAP1 protein D. melanogaster DNA polymerase a Jun DNA binding regulation, residues RNA localization, 3773 simian virus 40 large T antigen, inter- essential for, 5370 hsp90 and hsp70 action with, 809 heat shock genes p60 60-kilodalton stress-related protein, dunce-like phosphodiesterase genes HSF1 oligomerization, modification, interaction with, 869 D. melanogaster dunce gene, homol- and rapid translocation, 2486 ht,B gene ogy to, 6558 heat shock transcription factor CACCC box-binding protein, encoding dunce-like phosphodiesterases DNA-binding activity regulation, 5427 of, 5691 antidepressant drugs, potential targets Hel-Nl protein isolation, 5691 for, 6558 specificity, 3494 Human EMS1 gene product HER2/neu receptor aldolase A gene carcinomas, amplification and overex- growth, effect on, 2247 muscle-specific promoter, 9 pression in, 2891 truncation produced by alternative opportunistic promoter, 9 cell-substratum contact sites, location RNA processing, 2247 ubiquitous promoter, 9 in, 2891 HoxB5 protein alpha satellite repeat unit variants v-src substrate, homology to, 2891 DNA binding, cooperative, 4609 recombination events, localization of, e-globin gene hsp70 xxiv SUBJECT INDEX MOL. CELL. BIOL.

heat shock transcription factor DNA psoralen cross-linking to small nucleo- activation by, 2298 binding, regulation of, 5427 lar RNAs, 4382 Human cytomegalovirus IL-2RP gene promoter prointerleukin 1B gene major immediate-early proteins regulation, 6201 tissue-specific induction, 1332 transcriptional activation mediated by, interferon regulatory factor 1 gene pro- proliferating cell nuclear antigen pro- 1238 moter, 690 moter Human immunodeficiency virus interferon-inducible domain, 690 243-residue adenovirus ElA oncopro- long terminal repeat interleukin-13 gene teins, transactivation by, 1697 inducible transcriptional activation by CRE/ATF-like site in URS, 6678 Raf-1 protein kinase, estradiol dependent protein kinase inhibitors, 5245 induction in monocytic cell lines, 6678 cell transformation, conditional, 6241 Human immunodeficiency virus type 1 interleukin-1l3 gene regulation MAP kinase cascade, activation of, inducer of short transcripts lipopolysaccharide, 3831 6241 short RNA synthesis, activation of, mycobacterial components, 3831 replication protein A 1251 nuclear factor-IL6 motifs, mediation ionizing radiation-induced phosphory- long terminal repeat by, 3831 lation response, 7222 NF-KB motif function, 5057 interleukin-1p promoter rRNA genes Spl motif function, 5057 autoregulatory loop, positive, 6231 DNA replication initiation and termi- thyroid hormone response elements, NF-KB site, functional, 6231 nation, 6600 5057 K5 promoter SF2/ASF Rev protein differentiation specificity, 3176 exon skipping and inclusion, modula- pre-mRNA, function with respect to, keratinocyte specificity, 3176 tion of, 2993 6180 K562 cells small nucleolar RNAs TAR RNA-binding protein TRBP 13-globin promoter CAAT box, 6969 psoralen cross-linking to pre-rRNA, Drosophila Staufen, relatedness to, keratin 18 gene 4382 2193 transcriptional insulation in transgenic squalene synthetase human P1/dsl kinase, relatedness to, mice, 2214, 6742 S. cerevisiae and S. pombe squalene 2193 lymphocyte apoptosis synthetases, similarities to, 2706 Human papillomavirus -y-irradiation induced, 4875 SR proteins, 4023 E6 protein ubiquitin pathway, 4875 SRp75, cDNA encoding, 4023 binding, 4918 mdm-2 protein T-47D breast cancer cells p53, association with, 4918 p53 interaction domain, 4107 cell cycle progression, changes in, ubiquitination of associated proteins, mitochondrial transcriptional activator 3577 4918 S. cerevisiae mitochondrial HMG-box cyclin gene expression, regulation of, Human papillomavirus E6 oncoprotein protein, replacement of, 1951 3577 p53, interaction with mitogen-activated protein kinases T cells, primary E6-AP, mediation by, 775 p44e?*l, 4679 E2F, cell cycle analysis of, 3975 Human papillomavirus type 16 c-myc gene TATA box-binding polypeptide E7 protein Xenopus oocytes, elongation in, 1296 p53 activation domain, binding to, E2F-cyclin A complex, association c-myc promoters 3291 with, 6537 activities, control of, 5710 TATA-binding protein retinoblastoma gene product E2F, in- NADPH phagocyte oxidoreductase gene poliovirus protease 3C, direct cleavage teraction with, 953 gp91-phox subunit by, 1232 Human T-cell leukemia virus type I S. pombe fipl+, homology to, 4342 telomeric DNA repeat IL-2 enhancer, cis element required for neuroblastomas nuclear proteins, binding to, 4301 induction of differentiation, role of trkA cDNA in, triosephosphate gene Tax-inducible protein, binding to, 6490 7447 RNA 3-end formation, function of Tax protein NF-E2 complex last-intron sequences in, 3359 human vimentin promoter, modulation hematopoietic cell-specific subunit, trkA cDNA of, 89 5604 neuroblastomas, expression in, 7447 purification, 5604 tumor necrosis factor-responsive ele- ICSBP gene nuclear proteins ment mouse pre-mRNA 3' splice site sequence, osteocalcin gene, down-regulation of, gamma interferon-responsive element, binding to, 4301 3714 3951 telomeric DNA repeat, binding to, TxREF protein Idl protein 4301 cis element binding, 6490 loop region osteocalcin gene U2 locus, artificial dominant negative activity, critical tumor necrosis factor-responsive ele- Adl2-inducible fragile site, 6064 for, 7874 ment, down-regulation by, 3714 U6 small nuclear RNA gene IFN regulatory mechanism, novel P1/dsl kinase distal control region, 4670 human Fc-y receptor gene, 2182 relatedness to human immunodefi- UV-damaged DNA templates IFN--y ciency virus type 1 TAR RNA- replication and mutagenesis, 533 human Fc-y receptor gene, activation of, binding protein TRBP, 2193 vimentin promoter 2182 p44e?*l human T-cell leukemia virus type I Igf 2 gene mitogen-activated protein kinase, 4679 Tax protein, modulation by, 89 mouse p53 negative element, 89 activation, 4928 mdm-2 interaction domain, 4107 V(D)J recombination IKB MAD-3 peptide-binding protein 74 coding joint formation, 3900 RelA(p65) dimerization with NFKB2 heat shock protein 70 family, member signal joint formation, 3900 regulation of DNA binding, transcrip- of, 3598 c-Yes tyrosine kinase tional activation, and inhibition, PI 3-kinase, novel elevated intracellular calcium levels, 1315 p85, binding site on, 7677 inactivation by, 7507 IKBa ubiquitous expression, 7677 t2 globin promoter loss, 3301 pre-rRNA globin regulatory element (HS-40), phosphorylation, 3301 VOL. 13, 1993 SUBJECT INDEX xxv

Illegitimate integration Instantaneous heat shock Interleukin-2 receptor ,B chain S. cerevisiae, 2697 D. melanogaster human Immediate-early genes transcription, effect on, 3456 gene promoter, 6201 serum inducibility, attenuation of Insulin Interleukin-3 receptor oncoproteins, 2011 Ras activation 1B chain tyrosine kinase signaling pathways, p2lras, enhanced exchange of guanine hematopoietic cell phosphatase, asso- 2011 nucleotides on, 155 ciation with, 7577 Immediate-early proteins, major signals, pleiotropic Interleukin-4 gene human cytomegalovirus IRS-1 phosphorylation, engagement mouse transcriptional activation mediated by, by, 7418 expression in T cells, control of, 4793 1238 Interferon Interleukin-5 Immunoglobulin genes consensus sequence-binding protein B-cell differentiation pathway rearrangement in pre-B-cell lines interferon-induced gene expression, distinct from that of IL-6, 3929 RAG-1 and RAG-2, insufficiency of, suppression of, 588 Interleukin-6 3890 induction of gene transcription acute-phase response factor activation at Immunoglobulin heavy-chain 3'a enhancer consensus sequence-binding protein, posttranslational level, 276 mouse suppression by, 588 B-cell differentiation pathway NF-HB, repression by, 3611 Interferon regulatory factor 1 distinct from that of IL-5, 3929 Immunoglobulin heavy-chain enhancer recognition DNA sequences, 4531 E2F DNA-binding activity, suppression octamer/pE4 region Interferon regulatory factor 1 gene pro- of, 5255 gene repression, mediation of, 3530 moter junB promoter, novel response element Tr element human in pre-B-cell specificity, 5957 interferon-inducible domain, 690 CRE-like site, 3027 SV40 ori-dependent DNA replication, Interferon regulatory factor 2 Ets-binding site, 3027 regulation of, 5629 recognition DNA sequences, 4531 Ml cells, effects on Immunoglobulin heavy-chain gene Interferon regulatory factor family wild-type p53, complementation by, expression interferon consensus sequence-binding 7942 Ets proteins, regulation by, 7163 protein Interleukin-6 and retinoic acid signalling Immunoglobulin heavy-chain locus interferon-induced gene transcription, convergent regulation of Oct-1 and NF- B-cell-specific 3' enhancer suppression of, 588 IL6 synthesis, 2515 a constant region, close to, 1547 Interferon-induced gene expression Interleukin-6-responsive element Immunoglobulin K light-chain gene nuclear tyrosine phosphatase, downregu- hepatocyte nuclear factor 1 dependent rearrangement lation by, 7515 human 1B fibrinogen promoter, 1183 Ig p heavy chain, stimulation by, 5679 Interferon-inducible domains Interleukin-8 transcription, negative regulation of interferon regulatory factor 1 gene pro- promoter short sequence homologous to murine moter, 690 NF-KB subunit-specific regulation, Bi repetitive element, 3698 Interferons 6137 Immunoglobulin X2-4 enhancer E2F DNA-binding activity, suppression Interleukin-8 gene mouse of, 5255 regulation mechanisms PU.1-containing complex, binding to, Interferon-stimulated response element C/EBP and NF-KB, synergism and 6452 binding factors, novel cooperativity between, 7191 Immunoglobulin p. heavy chain double-stranded RNA, activation by, Intervening sequence K light-chain rearrangement, stimulation 3756 T. thermophila of, 5679 Interleukin-1 26S rRNA, alternative helix in, 1137 Immunoglobulin superfamily member IKBa, phosphorylation and loss of, 3301 excision and integration, 1137 S. cerevisiae a-agglutinin, 2554 NF-KB activation, mechanism of, 3301 Intracisternal A particle Immunophilins Interleukin-1lB gene mouse signal transduction inhibition, mediation human upstream element, interaction of YY1 of CRE/ATF-like site in URS, 6678 with, 6621 calcineurin binding, role of, 4760 induction in monocytic cell lines, 6678 YY1, interaction of upstream element cellular location, role of, 4760 regulation, mediation of, 3831 with, 6621 Immunosuppressants Interleukin-lp promoter Intracisternal A-particle genes FK506 human expression S. cerevisiae, amino acid import inhi- autoregulatory loop, positive, 6231 mouse plasmacytomas, 7439 bition in, 5010 NF-KB site, functional, 6231 Introns Inducer of short transcripts Interleukin-2 mammalian human immunodeficiency virus type 1 rat T cell lymphoma lines, dependent 3' splice site selection, 4939 Gfi-1 gene activation, 1759 Inverted DNA repeats transcriptional element progression to IL-2-independent S. cerevisiae short RNA synthesis, activation of, growth, 1759 genomic instability, source of, 5315 1251 Interleukin-2 gene I-PpoI endonuclease Infectious bronchitis virus inducibility, developmental changes in P. polycephalum RNA pseudoknot molecular basis, 228 target site, interaction with, 7531 translation, ribosomal pausing during, inhibition of inducible activity IRS-1 protein 6931 cyclosporin A, 1155 phosphorylation Initiator-associated transcription noncanonical octamer-binding site, pleiotropic insulin signals, engagement GAL4-VP16, mediation by, 7469 1155 of, 7418 Initiator-mediated transcription transforming growth factor 1, 1155 Ischemia and toxic injury TATA-binding protein and DNA, func- Interleukin-2 receptor a-chain enhancer kidney tional interaction between, 3841 T lymphocytes Kid-I regulation, 1933 Insects activation by interaction between se- ISGF3y pentanucleotide telomeric sequence rum response factor-binding ele- protein-DNA and protein-protein inter- (TTAGG)w, 1424 ments and NF-KB, 2536 actions, domains mediating xxvi SUBJECT INDEX MOL. CELL. BIOL.

DNA-binding specificity, 196 Kinetoplast DNA minicircles LFB1 (HNF1) liver transcription factor transcription factor assembly, 196 C. fasciculata X. laevis zinc finger protein, binding to, 7766 developmental regulation and tissue Jun Kininogen family genes distribution, 421 action rat LFB1 protein thyroid hormone receptor, modulation hepatic expression, differential, 6766 X. laevis by, 3042 Kit expression, tissue specific and embry- c-jun promoter molecular chimeras onic, 6416 protein-DNA interactions in vivo stem cell factor-binding site, 2224 Ligand-binding regions UV response, mediation of, 5490 c-Kit M-CSF receptor extracellular domain, c-Jun/AP-1 hematopoietic cell phosphatase, associa- 5348 mitogenic response to TNF-a, required tion with, 3350 LINE-1 RNA and protein 4284 Kluyveromyces lactis mouse embryonal carcinoma cells, for, Gal80 protein expression in, 5383 JunB galactose regulon, glucose repression Linear mitochondrial DNA NFAT-1 DNA binding complex, 1911 of, 7566 yeasts, 2309 junB promoter S. cerevisiae Gal80, conservation closed-loop structure of termini, 2315 interleukin-6 response element, novel with, 7566 linear-circular conversion mecha- CRE-like site, 3027 hexokinase gene nisms, 2315 Ets-binding site, 3027 RAGI transcriptional regulation, re- Liver quired for, 3882 transgenic mouse K5 promoter LAC9 (KIGAL4) carcinogenesis, oncogene induced, 320 human autoregulation, 3058 Liver alpha-1 acid glycoprotein gene differentiation specificity, 3176 expression, control of, 3058 induction keratinocyte specificity, 3176 RAG1 gene positive and negative transcription fac- K562 cells hexokinase gene required for tran- tors, 432 human scriptional regulation, 3882 Liver transcription factor LFB1 (HNF1) P-globin promoter CAAT box, 6969 Reblp X. laevis KYAR2 (BiP) gene bipartite DNA-binding domain, 1173 developmental regulation and tissue S. cerevisiae Kriippel family nuclear proteins distribution, 421 promoter region with domain that re- mouse erythroid Kruppel-like factor, Liver-specific transcription sponds to unfolded proteins in relationship to, 2776 hepatocyte nuclear factor 3 and nuclear 877 KRE6 gene factor 1 interactions endoplasmic reticulum, S. cerevisiae binding of DNA in close apposition, KDEL receptor putative membrane protein, encoding 2401 mammalian of, 4039 Long terminal repeat transmembrane topology, 6435 SKN1, functional homolog of, 4039 HIV Ke 6 KRE9 gene inducible transcriptional activation by major histocompatibility complex, novel S. cerevisiae protein kinase inhibitors, 5245 gene within 0 glycoprotein involved in p-glucan HIV-1 polycystic kidney disease, downregu- assembly, 6346 thyroid hormone response elements, lation in, 1847 5057 Keratin 18 gene Li ribosomal protein L-type pyruvate kinase gene human S. cerevisiae, requirement for glucose response complex, 7725 transcriptional insulation, Alu involve- 5S rRNA, stability of newly synthe- Lungs ment in, 6742 sized, 2835 adult transcriptional insulation in transgenic 60S ribosomal subunits, assembly of, cellular immediate-early gene expres- mice, 2214 2835 sion, 3213 transgenic mice LAC9 (KiGAL4) developing cis regulation, 1815 K lactis cellular immediate-early gene expres- Kid-i autoregulation, 3058 sion, 3213 renal transcription factor, putative expression, control of, 3058 LyF-1 ischemia and toxic injury, regulation Lactoferrin gene mouse terminal deoxynucleotidyltrans- in response to, 1933 mouse ferase gene ontogeny, regulation during, 1933 COUP-TF, repression of estrogen re- interaction with critical promoter ele- Kidney ceptor-mediated activation by, ment in, 2982 Kid-i putative transcription factor 1836 Lymphocytes ischemia and toxic injury, regulation estrogen receptor-mediated activation, human in response to, 1933 1836 apoptosis, ubiquitin pathway involve- ontogeny, regulation during, 1933 Large T antigen ment in, 4875 Kidney disease, polycystic simian virus 40 Lymphoid enhancer-binding factor 1 Ke 6 novel gene in major histocompati- human DNA polymerase a, interac- murine somatic cell hybrids bility complex tion with, 809 T cell receptor alpha-chain gene, ex- downregulation, 1847 interactions with multiple components tinction of expression of, 1943 kin-15 gene of the transcription complex, 961 C. elegans transcriptional activation by, 961 Macromolecular synthesis novel protein tyrosine kinase, encod- lck tyrosine protein kinase Bcl-2-controlled cell death, not required ing of, 7133 CD45 tyrosine protein phosphatase for, 7000 kin-16 gene tyrosine phosphorylation, 1651 Macrophage colony-stimulating factor re- C. elegans Leu3 protein ceptor novel protein tyrosine kinase, encod- S. cerevisiae extracellular domain ing of, 7133 functions, 5702 ligand-binding regions, 5348 VOL. 13, 1993 SUBJECT INDEX xxvii

Macrophage inflammatory protein la 2586 Minichromosomes immediate-early gene SPT13 (GAL11), regulation of activity simian virus 40 transcriptional regulation, 5276 in Tyl elements by, 63 nucleosome assembly factor, 1059 MAG and MGTI genes Tyl, binding to transcriptional control Mini-exon S. cerevisiae element in, 57 vertebrate transcriptional regulation, common mdm-2 oncogene recognition in vivo as an exon-intron- element in, 7213 p53 suppression of transformed cell exon unit, 2677 Maize growth, overcoming of, 301 Mitochondria atp promoter, mitochondrial, 7232 MDM2 protein hsp60 function Major histocompatibility complex p53, binding to, 6849 S. cerevisiae, loss in, 3050 Ke 6 novel gene p53 interaction domain, 4107 S. cerevisiae polycystic kidney disease, downregu- SV40 T antigen, binding to, 6849 cytochrome b transcripts, CBP1-de- lation in, 1847 mdr3 gene pendent accumulation of, 4203 mouse mouse cytochrome c, import of, 6442 class I gene conversion mechanisms, retrovirus insertion in tumor cells, ac- escape of DNA from, 5418 4374 tivation by, 7380 hsp60 function, loss of, 3050 Major histocompatibility complex class I MEF-2 site Mitochondrial DNA allogeneic protein, transgenic overex- myosin light chain-2 promoter D-loop region pression of new serum-responsive, cardiac tissue- single termination-associated se- nonimmune thyroid destruction, 1554 specific transcription factor, 1222 quence, protein binding to, 2162 Major histocompatibility complex class I MEF-3 motif linear genes rat aldolase A gene induction, role in, closed-loop structure of termini, 2315 retinoic acid induction 6469 linear-circular conversion mecha- embryonal carcinoma cells, 6157 Megakaryocytes nisms, 2315 Mak protein kinase GATA and Ets cis-acting sequences, yeasts, 2309, 2315 rat mediation of specific expression by, N. crassa 210-kDa cellular phosphoprotein, asso- 668 hyperactive recombination, 6778 ciation with, 4146 Meiosis S. cerevisiae spermatogenesis, expression in, 4146 S. cerevisiae in vivo ligation of transforming DNA Mammalian hibernators formation of stable heteroduplex DNA to, 2697 hibernation-associated gene regulation, late in meiotic prophase, 373 Mitochondrial HMG-box protein 1516 timing of molecular events, 373 S. cerevisiae Mammalian introns Meiosis-specific arrest replacement with human mitochon- 3' splice site selection S. cerevisiae drial transcriptional activator, competition between AGs, 4939 DNA topoisomerase II mutants, 3445 1951 scanning, 4939 Meiotic recombination Mitochondrial inner membrane Mammalian KDEL receptor S. cerevisiae S. cerevisiae transmembrane topology, 6435 heteroduplexes, physical detection of, preprotein translocation, 7364 Mammalian and yeast cells 2324 Mitochondrial RNA functional conservation of helix-loop- Membrane skeleton S. cerevisiae helix protein transcriptional activa- polyomavirus middle T antigen, interac- dodecamer sequence, protein complex tion motif, 792 tion with, 4703 binding to, 4167 map3+ met receptor tyrosine kinase Mitogen-activated protein kinase activator S. pombe oncogenic potential, activation of family putative M-factor receptor, 80 leucine zipper-mediated dimerization, X. laevis MAP kinase 6711 XMEK2, 5738 Xenopus oocytes Metallothionein locus XMEK3, 5738 Mos, stimulation by, 2546 mouse Mitogen-activated protein kinase kinases MAP kinase kinase distal regulatory elements, 5266 rat Mos, in vitro stimulation by, 2546 Metallothionein spMTA gene MKK2, 4539 MAST205 protein sea urchin embryo Mitogen-activated protein kinases Ser/Thr kinase, testis specific, 7625 promoter and intron 1 regions, combi- human spermatid manchette microtubules, asso- natorial regulation by, 993 p44erkl, 4679 ciation with, 7625 M-factor receptor, putative X. laevis MATal transcript S. pombe S. pombe Spkl, relationship to, 6427 S. cerevisiae map3+, 80 Mitogenic signal transduction mRNA decay, promotion of, 5141 32-Microglobulin promoter coupling of Ras to Raf activation, 7645 MATaJ transcription mouse Mitogen-responsive promoter region S. cerevisiae regulatory element, 6629 multiple signalling pathways, synergistic Ste signal transduction pathway for Microtubule cytoskeleton activation through, 1796 mating pheromones, 2050 PDGF-PI-3 kinase complexes, potential Mitosis Max interactions with, 6052 pp60Oc" activation Myc, sequence-specific transcriptional Microtubule function myristylation, requirement for, 1464 activation by, 383 A. nidulans Mitosis, entry into sequence-specific transcriptional activa- a-tubulin isogene products, 4465 S. cerevisiae tion, repression of, 383 Middle T antigen checkpoint-arrested cells, 3744 max gene polyomavirus Mitosis and meiosis zebra fish membrane skeleton, interaction with, S. cerevisiae constant expression level, 2765 4703 B-type cyclins, differential function oncogenic activity, 2765 MIM44 protein and expression of, 2113 MCM1 S. cerevisiae Mitotic arrest S. cerevisiae membrane translocation, involvement X. laevis arginine metabolism, regulation of, in, 7364 cyclin B2 amino terminus, 1480 xxviii SUBJECT INDEX MOL. CELL. BIOL.

Mitotic recombination 6969 ceptor-mediated activation by, S. cerevisiae differentiation arrest, 5582 1836 substrate length requirements, 3937 erythroid differentiation, 1093 estrogen receptor-mediated activation, MKK1 3-globin promoter activation, 6969 1836 S. cerevisiae pmaj globin promoter, 1093 mdr3 gene protein kinase-mediated pathway, 3-globin promoter-binding factor, 4311 retrovirus insertion in tumor cells, ac- function in, 3076 heme synthesis, induction of, 7122 tivation by, 7380 MKK2 p53-induced cell death, 711 metallothionein locus distal regulatory S. cerevisiae stromal cell-independent growth, 5582 elements protein kinase-mediated pathway, terminal differentiation, blocking of, transgenic mice, stimulation of gene function in, 3076 3505 expression in, 5266 MKK2 protein kinase kinase erythropoietin receptor gene p2-microglobulin promoter rat upstream repetitive element, transcrip- regulatory element, 6629 characterization, 4539 tional inhibition by, 98 MPTPb protein identification, 4539 Evi-1 gene expression, 5513 Monkey zinc fingers, 4291 human HPTPb, homolog of, 5513 UV-damaged DNA templates c-fin c-myc promoter replication and mutagenesis, 533 mRNA expression, control of, 3191 YY1, activation by, 7487 Morphogenesis GATA-4 myeloperoxidase promoter S. cerevisiae, requirements for endodermally derived tissues and myeloid nuclear factor 1-binding site, casein kinase I-like protein kinases, heart, 2235 2141 YCKI and YCK2 encoded, 2870 retinoic acid-inducible, GATA-binding NIH 3T3 fibroblasts Mos transcription factor, 2235 aB-crystallin, 1824 Xenopus oocytes pmaJ globin nuclear high-mobility-group box protein MAP kinase kinase activation in vitro, transcription termination region, 578 tsHMG gene, encoded by, 4323 2546 13-globin DNA-binding protein Bi peptide-binding protein 74 MAP kinase stimulation, 2546 hematopoietic cells and testis, expres- heat shock protein 70 family, member Mouse sion restricted to, 2929 of, 3598 acute myeloid leukemia Spi-1/PU.1 transcription factor, identi- perforin gene E2A-Pbxl t(1;9) translocation protein cal to, 2929 Ets-binding site-homologous motif, of human pre-B-cell acute lym- grb2 gene 6690 phocytic leukemia, 351 molecular cloning, 5500 killer cell-specific regulatory element, adenosine deaminase gene Grb2 protein 6690 stable transcription arrest site in first EGF and NGF receptors, interactions plasmacytomas intron, 2718 with, 5500 IAP gene expression, 7439 adenosine deaminase locus heat shock transcription factors 1 and 2 protamine 2 mRNA replication initiation sequence, 5931 HSP70 heat shock element, interaction 3' untranslated region, phosphoprotein arrestin gene proximal promoter with, 3370 binding to, 6547 photoreceptor cells, gene expression trimeric binding site preference, 3370 translation, repression of, 6547 in, 4400 hematopoietic cell phosphatase ribosomal gene promoter retinal factor-binding site, 4400 IL-3-induced phosphorylation and mi- initiation complex formation, function bidirectional DNA replication origin, togenesis, down-regulation of, of TIF-IA in, 6723 localization of 7577 scid thymocytes adenosine deaminase loci, episomally IL-3R, association with, 7577 T-cell receptor b element recombina- amplified, 2971 homeodomain proteins tion, 3632 native locus, 2971 DNA-binding specificity, 2354 Slp gene brain DNA-binding protein Hox-4.2 gene enhancer, 6326 myelin basic protein gene expression, retinoic acid response element, up- somatic cell hybrids 3103 stream, 257 lymphoid enhancer-binding factor 1, class I major histocompatibility complex ICSBP gene loss of, 1943 gene conversion mechanisms gamma interferon-responsive element, T cell receptor alpha-chain gene mutation clusters, unusual, 4374 3951 expression, extinction of, 1943 aB-crystallin Igf 2 gene spermatids, elongating NIH 3T3 fibroblasts, 1824 activation, 4928 nuclear high-mobility-group box pro- aB-crystallin/small heat shock protein immunoglobulin heavy-chain 3'a en- tein, 4323 enhancer hancer STPK13 mRNA control elements, 7144 NF-HB, repression by, 3611 protein kinase, mitotic, 7793 cytosolic glutathione peroxidase gene immunoglobulin X2-4 enhancer regulation, 7793 transcriptional up-regulation, 6290 PU.1-containing complex, binding to, terminal deoxynucleotidyltransferase double-minute chromosome 6452 gene, critical promoter element in CpG island mapping, 4459 interleukin-4 gene Ets protein, interaction with, 2982 embryonal carcinoma cells expression in T cells, control of, 4793 LyF-i, interaction with, 2982 LINE-1 RNA and protein, expression intracistemal A particle testis-specific gene of, 5383 upstream element, interaction of YY1 nuclear high-mobility-group box pro- embryonic stem cells with, 6621 tein, 4323 gene-targeting tag and exchange, 4115 YY1, interaction of upstream element thymidylate synthase gene site-directed point mutations, 4115 with, 6621 growth-regulated expression, need of erythroid Kriippel-like factor kidney disease, polycystic introns for, 1565 CACCC element, binding to, 2776 Ke 6 novel gene in major histocompat- thymidylate synthase promoter, TATA- KIiippel family nuclear proteins, rela- ibility complex, downregulation less tionship to, 2776 of, 1847 initiator element, lack of, 4894 erythroleukemia cells lactoferrin gene multiple transcriptional initiation sites, CAAT box, binding of novel factor to, COUP-TF, repression of estrogen re- 4894 VOL. 13, 1993 SUBJECT INDEX xxix

tropomyosin gene c-Myb, comparison with, 4423 avian fibroblast transformation, not embryonic stem cells, expression in, S. cerevisiae, 4423 required for, 3623 3311 myc family genes Mycovirus embryos, expression in, 3311 differential activation by hepatitis B vi- C. parasitica tsHMG gene ruses, 659 hypovirulence-associated traits, mim- nuclear high-mobility-group box pro- hepatic carcinogenesis, 659 icking of, 7782 tein, 4323 zebra fish Myelin basic protein gene YY1 protein differential expression levels, 2765 mouse IAP upstream element, interaction oncogenic activity, 2765 brain DNA-binding protein, 3103 with, 6621 myc gene Myeloid cell pleiotropic effects, 6621 transcripts differentiation and proliferation Mpklp nucleolar localization, 3221 granulocyte colony-stimulating factor, S. cerevisiae c-myc gene effect of v-myb on induction by, protein kinase signaling, mediation of, Abelson murine leukemia virus 2269 3067 addition of constitutive expression to, human MPTPB protein 2578 Fcly receptor gene, specific expression mouse plasmacytomas, 2578 of, 2182 expression, 5513 pre-B-cell lymphomas, 2578 Myeloid differentiation human HPTPB, homolog of, 5513 human fos/jun family, positive regulators of, 841 MRF4 protein Xenopus oocytes, elongation in, 1296 Myeloid nuclear factor 1 activity, inhibition of c-Myb, regulation by, 2858 mouse FGF, 5943 phosphatidylcholine hydrolysis cell type-restricted transcription fac- mRNA collaborating mitogenic pathways acti- tor, 2141 alternatively spliced vated by colony-stimulating factor myeloperoxidase promoter, binding AP-2 gene, 4174 1, 1522 by, 2141 c-fos gene transcriptional elongation Myelomonocytic cell lines destabilizing elements in coding re- distinct properties in different cell heme oxygenase expression, induction gion, 5034 types, 5647 of mRNA decay c-, N-, and L-myc homologs TPA, mediation by, 7881 S. cerevisiae X. laevis Myeloperoxidase promoter AL4Tal transcript, promotion by, 5141 comparative analysis of expression mouse mRNA metabolism and oncogenic activities, 2456 myeloid nuclear factor 1-binding site, measurement method, new c-myc promoter 2141 chicken embryo lens b-crystallin gene, mouse myfS gene 3282 YY1, activation by, 7487 bovine mRNA splicing c-myc promoters transgenic mice, effect of expression T cell receptor-, human in, 6044 unusual splicing intermediates, regula- activities, control of, 5710 Myocytes tion of, 1686 Myc protein AMPD1 gene, expression of, 5854 Murine leukemia virus enhancer apoptosis, mediation of quiescent and growth-stimulated core-binding factor Bcl-2, block by ectopic expression of, fosljun, repression of cardiac-specific subunits, cloning and characterization 2432 transcription by, 600 of, 3324 Bcl-2-controlled cell death, not required MyoD protein Muscle for, 7000 chicken creatine kinase-M gene canonical DNA sequences, binding to, MLC1 gene, action on, 7153 control of expression, 1264 5216 Myogenesis Muscle cells, cultured Max, repression of sequence-specific acetylcholine receptor b-subunit gene tissue- and development-specific tran- transcriptional activation by, 383 E-box mediation of activation and re- scription noncanonical DNA sequences, binding pression, 5133 rat TnIslow gene cis-acting sequences, to, 5216 ElA-mediated inhibition conferred by, 7019 overexpression ElA12s-basic helix-loop-helix protein Muscle creatine kinase CCAAT transcription factor/nuclear interaction, correlation with, 4714 enhancer activity factor 1-dependent promoters, Myogenin skeletal and cardiac muscle, differen- suppression of, 3093 chicken tial contributions of multiple regu- sequence-specific transcriptional activa- MLC1 gene, action on, 7153 latory elements in, 2753 tion, 383 Myosin light chain-2 promoter v-myb gene B-Myc protein MEF-2 site granulocyte colony-stimulating factor- neoplastic transformation by c-Myc, in- induced myeloid cell differentiation hibition of, 1130 new serum-responsive, cardiac tissue- block of, 2269 transcriptional activation by c-Myc, inhi- specific transcription factor, 1222 c-Myb protein bition of, 1130 Myosin light chain gene domains required to block terminal dif- c-Myc protein C. elegans ferentiation, 3505 neoplastic transformation transposon Tcl, site-selected insertion first repeat, truncation of inhibition by B-Myc, 1130 of, 902 DNA binding, decrease in, 7334 transcriptional activation Myosin light-chain 1 gene c-myc, regulation of, 2856 inhibition by B-Myc, 1130 chicken transcriptional activation transcriptional activation domain MyoD, action of, 7153 animal cells, 4423 cell cycle regulation, 4125 myogenin, action of, 7153 v-Myb, comparison with, 4423 v-Myc protein Myosin light-chain 2 gene S. cerevisiae, 4423 Max, excess over rat v-Myb protein avian fibroblast transformation, not HF-lb zinc finger protein, 4432 transcriptional activation required for, 3623 HF-1b/MEF2 cardiac regulatory ele- animal cells, 4423 overproduction in nucleus ment, 4432 xxx SUBJECT INDEX MOL. CELL. BIOL.

NAB2 NF-IL6 Nicotiana plumbaginifolia S. cerevisiae Oct-1 synthesis, convergent regulation protoplasts cell viability, essential for, 2730 with chimeric U snRNA/mRNA genes, NADPH phagocyte oxidoreductase gene embryonal carcinoma cells, 2515 6403 gp9l-phax subunit interleukin-6 and retinoic acid signal- non'Adiss protein human ling, 2515 D. melanogaster S. pombe fipl +, homology to, 4342 NF-KB NonO, homolog of, 5593 natural death nuclear mutant activation Nonimmune thyroid destruction N. crassa protein kinase C ( subspecies, block- major histocompatibility complex class I mitochondrial DNA, hyperactive re- ing by, 4770 allogeneic protein, transgenic overex- combination in, 6778 activation, mechanism of, 3301 pression of, 1554 ND9 protein cAMP-independent ATF family proteins, NonO protein T. brucei interactions with, 7180 mammalian homolog of D. melanogaster NADH dehydrogenase subunit, ho- competitive binding non,4diss 5593 mology to, 6832 phorbol ester-induced cellular adhe- Nonsense codons Neoplasia sion, inhibition of, 6530 cytoplasmic mRNA nuclear hormone receptor IL-8 gene regulation lack of effect on half-life, 1892 Erb A, 2366 C/EBP, synergism and cooperativity nuclear mRNA Nerve growth factor with, 7191 reduction of abundance, 1892 branched signaling pathway IL-8 promoter, subunit-specific regula- pre-mRNA Src-, Ras-, and Raf-mediated gene in- tion of, 6137 no effect on abundance, 1892 ductions, 3146 involvement in retinoic acid induction of NPK1 gene Nerve growth factor receptor MHC class I genes, 6157 tobacco mouse Grb2 protein, interaction with, novel complex containing p65 ho- protein homologous to yeast protein 5500 modimers, 7826 kinases, 4745 Neural retina development p50 and p65 subunits Nuclear dot antigens chick conservation of transcriptional activa- transcriptional domains in nucleus, spec- C/EBP-like protein, 331 tion functions in S. cerevisiae and ification of, 6170 glucocorticoid hormones, responsive- mammalian cells, 1666 Nuclear factor 1 ness to, 331 differential functions, 3802 liver-specific transcription Neuroblastomas serum response factor-binding elements, hepatocyte nuclear factor 3, interac- human interaction with tions with, 2401 differentiation, role of trkA cDNA in, interleukin-2 receptor a-chain en- Nuclear factor for interleukin-6 expression 7447 hancer activation, 2536 (NF-IL-6) Neurofibromatosis (NFI) gene T lymphocytes, 2536 rat al-acid glycoprotein gene conserved alternative splice synergistic transcriptional activation neurofibromin isoforms with GTPase- subunits, specific with glucocorticoid receptor, 1854 activating protein activity, 487 VCAM-1 gene expression, regulation Nuclear hormone receptor Neurofibromin of, 6283 Erb A isoforms NF-KB family amino acids outside zinc finger do- von Recklinghausen neurofibromatosis C/EBP family members, association with main, 2366 (NFl) gene conserved alternative Rel domain-bZIP interaction, 3964 neoplasia, 2366 splice, 487 MIP-la gene, transcriptional regulation novel DNA sequence specificity, 2366 Neuronal differentiation of, 5276 Nuclear localization signal PC12 cells NF-KB p50 and p65 bipartite human CRK protein, induced by, 4409 DNA-binding specificities, differential Egr-1 protein, 4556 Neurospora crassa N-terminal DNA-binding domain, 852 retinoblastoma gene product, 4588 mitochondrial DNA NF-KB plOO Nuclear mRNA hyperactive recombination, 6778 H2TF1, component of, 6089 nonsense codons, reduction of abun- natural death nuclear mutant IKB-like molecule, function as, 6089 dance by, 1892 mitochondrial DNA, hyperactive re- NF-KB-like activity Nuclear proteins combination in, 6778 X. laevis oocytes human Neurotrophic factor-induced tyrosine ki- protein kinase C t, block of activation pre-mRNA 3' splice site sequence, nase by, 1290 binding to, 4301 differentiation-specific target NFKB1-selective DNA binding telomeric DNA repeat, binding to, 4301 neurons and PC12 cells, 2203 acquisition 2203 substitution of amino acids from Nuclear receptor-DNA interaction SNT, monomer binding, 5794 NF1 NFKB1 into ReIA, 3850 Nuclear ribosomal DNA GTPase-activating protein NFKB2 S. cerevisiae differential regulation of cellular activi- ReIA(p65), dimerization with P. polycephalum mobile group I in- ties, 2497 IKB MAD-3, regulation of DNA bind- tron, insertion of and induction of NFAT-1 DNA binding complex ing, transcriptional activation, and point mutations by, 1023 T cells, activated inhibition by, 1315 Nuclear RNase MRP Fra-1 and JunB, 1911 NGFI-A protein S. cerevisiae NF-E2 complex transcriptional activity, 6858 pre-5.8S rRNA processing, required human NGFI-B orphan nuclear receptor for, 7935 hematopoietic cell-specific subunit, monomer binding to DNA, 5794 Nuclear tyrosine phosphatase 5604 steroid 21-hydroxylase, regulation of IFN-induced gene expression, downreg- purification, 5604 gene encoding, 861 ulation of, 7515 NF-HB Nicotiana benthamiana Nucleolus mouse immunoglobulin heavy-chain 3'a nuclei S. cerevisiae mutants defective in RNA enhancer, repression of, 3611 3' splice site selection, 4485 polymerase I VOL. 13, 1993 SUBJECT INDEX xxxi

structural alterations, 2441 7311 SH3 domain Nucleosome assembly factor enhanced exchange of guanine nucleo- binding to PI 3-kinase but not PI 4-ki- simian virus 40 minichromosomes, 1059 tides nase, 7708 nur77 gene Ras activation by insulin and epider- PI 3'-kinase, binding to, 7408 serum growth factors, activation by, mal growth factor, 155 Tyr-505, stable phosphorylation at 6124 guanine nucleotide exchange rate in fi- SH2 domain, requirement for, 7112 broblasts pS6'Yn Oct-i epidermal growth factor, regulation effector molecule interaction sites NF-IL6 synthesis, convergent regulation by, 1903 mapping, 5877 with suppression of function p59?Yf embryonal carcinoma cells, 2515 ras GTPase-activating protein, plasma amino-terminal cysteine motif interleukin-6 and retinoic acid signal- membrane targeted, 2420 palmitylation, 6385 ling, 2515 p34cdc2 effector molecule interaction sites Oct-3/4 gene mechanisms of regulation, 1675 mapping, 5877 embryonic carcinoma x fibroblast so- p34CDC28 kinase p60 60-kilodalton stress-related protein matic cell hybrids S. cerevisiae hsp90 and hsp7o, interaction with, 869 chromatin structure, 891 activation, 3744 p60vsrc extinction, 891 activity, effect of p6o-srC expression S. cerevisiae, expression in methylation status, 891 on, 5112 effects, 5112 transcriptional activity, 891 p44erkl p62cdc23 Octamer transcription factors human S. cerevisiae CC10 gene, regulation of, 3860 mitogen-activated protein kinase, 4679 nuclear tetratricopeptide repeat pro- Octamer/pLE4 region p5O and p65, NF-KB tein with two mutable domains, immunoglobulin heavy-chain enhancer DNA-binding specificities, differential 1212 gene repression, mediation of, 3530 N-terminal DNA-binding domain, 852 p64 Olf-1 p50 and p65 subunits presence in nucleus in S phase, 6147 binding site NF-KB Rel, relationship to, 6147 olfactory neuron-specific promoter conservation of transcriptional activa- p65 motif, 3002 tion functions in S. cerevisiae and homodimers in novel NF-KB complex, Olfactory neuron-specific promoter motif mammalian cells, 1666 7826 Olf-i-binding site, 3002 p53 p67SRF Olfactory signal transduction cascade activation domain DNA binding and dimerization, amino genes encoding components TATA box-binding polypeptide in acids essential for, 123 DNA binding site, 5805 holo-TFIID, binding to, 3291 DNA-binding motif, novel, 123 Oogenesis cell death mediated by p107 D. melanogaster cell cycle control, relationship to, 1415 E2F1 gene, regulation of, 6314 s36 chorion gene, follicular expression cellular activity P210 BCR/ABL of, 5898 DNA-damaging agents, induction by, SHi domain autophosphorylation Ornithine decarboxylase 4242 requirement for transformation but not degradation growth arrest, induction by, 4242 growth factor independence, 1728 exposure of C-terminal target by a Friend virus-transformed erythroleuke- P388 tumor cells, multidrug resistant polyamine-inducible inhibitory mia cells retrovirus insertion protein, 2377 growth suppression, 1456 mouse mdr3 activation, 7380 Ornithine decarboxylase gene functional domains P nucleotides Fos, direct transcriptional stimulation by transcriptional regulation, 5186 V(D)J recombination PC12 cells, 4657 transdominant inhibition, 5186 fine-structure analysis, 1078 Fos, lack of direct transcriptional stimu- transformation suppression, 5186 Pancreas lation by human papillomavirus E6 d cells fibroblasts, 4657 E6-AP regions directing interactions, cell line isolation technique, 4223 Orphan nuclear receptor 4918 preneoplastic foci, cultured from, 4223 NGFI-B human papillomavirus E6 oncoprotein, transgenic mouse steroid 21-hydroxylase, regulation of interaction with carcinogenesis, oncogene induced, 320 gene encoding, 861 E6-AP, mediation by, 775 Pancreatic f cells Osteocalcin gene induction of murine erythroleukemia cell cell line isolation technique, 4223 human death preneoplastic foci, cultured from tumor necrosis factor-responsive ele- cell cycle analysis of, 711 tumorigenesis pathway, 4223 ment, down-regulation by, 3714 mdm-2 interaction domain, 4107 Pax-8 gene rat MDM2 protein, binding to, 6849 transcripts, alternative splicing of inhibition 5907 protein-binding domain, 3811 expression, of, regulation of its own transcription, 3415 developmental regulation, 6024 transformed cell growth, suppression of isoforms, 6024 P3A2 protein mdm-2 oncogene, overcoming by, 301 Paxillin sea urchin wild type v-Crk, interaction with, 4648 protein encoded by D. melanogaster complementation of IL-6 effects on Pax-QNR proteins erect wing gene, similarity to, Ml cells, 7942 quail 3641 DNA sequences specifically bound, neuroretina, expression in, 7257 p2l' 1378 PDRI allele C3H 10T½ fibroblasts p55blk S. cerevisiae signaling pathway distinct from but effector molecule interaction sites suppression of effects of chimeric interdependent with protein ki- mapping, 5877 VP16-estrogen receptor, 462 nase C pathway, 1471 ps6Ick Pentanucleotide telomeric sequence effector function amino-terminal cysteine motif (TFAGG)n GAP interaction, dissociation from, palmitylation, 6385 B. mon and other insects, 1424 xxxii SUBJECT INDEX MOL. CELL. BIOL.

Peptide pheromone gene rT enhancer element Polyomavirus C neoformans a-mating type locus, pre-B-cell specificity, 5957 BOX DNA 1962 Pig-i and Sgs-4 genes embryonal carcinoma cell differentia- Peptide-binding protein 74 D. melanogaster tion, relationship to, 7747 human transcriptional switch, 184 middle T antigen heat shock protein 70 family, member Pituitary membrane skeleton, interaction with, of, 3598 pro-opiomelanocortin gene 4703 mouse cell-specific helix-loop-helix factor, POU domain protein heat shock protein 70 family, member requirement for, 2342 novel of, 3598 Plant nuclei TCF13, 5450 Perforin gene 5' splice site selection, 1323 pp40IBa mouse dicot rel proteins, differential inhibition of Ets-binding site-homologous motif, 3' splice site selection, 4485 DNA binding by, 1769 6690 Plants, higher pp60c-src killer cell-specific regulatory element, heat shock proteins, small platelets, thrombin-stimulated 6690 endomembrane system, localization integrin-dependent cytoskeletal com- Pheromone-induced signal transduction to, 238 plexes, redistribution to, 1863 S. cerevisiae Plasmacytomas Tyr-527 dephosphorylation three protein kinases, requirement for mouse mitosis, activation in, 1464 sequential function of, 2069 IAP gene expression, 7439 myristylation, requirement for, 1464 Phosphatase 2A Plasminogen activator gene pp6Q'rc CREB transcriptional stimulation, regu- expression, modulation of actin filament-associated substrate, lation of, 2822 protein tyrosine kinases, oncogene cDNA encoding, 7892 protein kinase A-phosphorylated CREB, encoded, 5888 pp6O" polypeptide dephosphorylation of, 2822 Plasmodium falciparum ADP/ATP carrier is not 32-kilodalton Phosphatidylcholine hydrolysis genetic crosses receptor, 3084 coupling of Ras to Raf activation, 7645 cytoplasmic inheritance, 7349 pp60v-srC c-myc Platelet-derived growth factor cell transformation collaborating mitogenic pathways acti- dominant negative mutant GAP, role of, 6799 vated by colony-stimulating factor quail QR1 gene, downregulation of, 3401 autocrine transformation, reversion of, ppg9()k 1, 1522 4066 Phosphatidylinositol 3-kinase mutants serum response factor, phosphorylation 85-kDa subunit, region of dominant-negative of, 6260 110-kDa subunit, binding to, 5560 human astrocytoma cell transformed ppl25F' binding, recognition motif for phenotype, reversion of, 7203 focal adhesion-associated protein ty- hepatocyte growth factor/scatter factor Platelet-derived growth factor p-receptor rosine kinase receptor, 4600 sequences, tyrosine phosphorylated noncatalytic domain, autonomous CD4-p56ck complex, binding to, 7708 SH2 domains, interactions with expression of, 785 human biosensor-based approach, analysis PPZJ gene novel, ubiquitously expressed, 7677 by, 3567 S. cerevisiae p85, binding site on, 7677 Platelet-derived growth factor receptor function, 5843 p561k SH3 domain, binding to, 7408 1B subunit protein phosphatase, encoding of, SH2 domain phospholipase C-y and 64-kilodalton 5843 in vivo binding properties, 1737 protein binding, 133 PPZ2 gene v-Src SH3 domain, binding to, 5225 phosphorylation sites, 133 S. cerevisiae Xenopus oocyte maturation, importance BPV E5 protein function, 5843 for, 6661 tumorigenic transformation, mediation protein phosphatase, encoding of, Phosphatidylinositol 4-kinase of, 4137 5843 CD4-p56'k complex, binding to, 7708 phosphotyrosine-containing binding site Pre-B-cell acute lymphocytic leukemia Phosphatidylinositol-specific phospholipase signaling molecules, 6889 human C Ras activation, mediation of, 3706 E2A-Pbxl t(1;9) translocation protein S. cerevisiae, 5861 Platelet-derived growth factor-phosphati- causes mouse acute myeloid leu- Phosphoinositide 3-kinase activity dylinositol-3 kinase complexes kemia, 351 serine/threonine protein kinase, regula- internalization, 6052 Pre-B-cell lines tion of, 1657 microtubule cytoskeleton, potential in- Ig ,u heavy chain 6052 K light-chain rearrangement, stimula- Phospholipase C teractions with, tion of, 5679 phosphatidylinositol specific Platelets Precursor rRNA S. cerevisiae, 5861 thrombin stimulated Xenopus spp. Phospholipase Cy pp60c-src redistribution to integrin-de- 5' ETS, U3 snRNP-requiring process- platelet-derived growth factor receptor pendent cytoskeletal complexes, ing event in, 5990 subunit, binding to, 133 1863 Pre-mRNA Physarum polycephalum PLCI gene 3' splice site sequence, human I-PpoI endonuclease S. cerevisiae nuclear proteins, binding to, 4301 target site, interaction with, 7531 mitotic chromosome segregation, 4351 nonsense codons, lack of effect on abun- mobile group I intron Poliovirus dance of, 1892 S. cerevisiae nuclear ribosomal DNA, protease 3C Pre-mRNA binding C proteins insertion into and induction of human TATA-binding protein, direct phosphorylation point mutations in, 1023 cleavage of, 1232 cell cycle regulation of, 5762 a-tubulin locus, developmentally regu- Poly(A) site processing factor Pre-mRNA splicing lated adenovirus aprt, 6211 two alleles replicate on different alternative poly(A) site use during in- D. melanogaster schedules, 449 fection, 2411 5' splice site selection, 7689 VOL. 13, 1993 SUBJECT INDEX xxxiii

dhfr, 6211 Protein kinase C t PTC1 gene permanent changes X laevis oocytes S. cerevisiae promoted by Ul small nuclear RNAs NF-KB-like activity, block of activa- mutations, effect of, 5408 with altered specificity, 2666 tion of, 1290 PTP2 gene S. cerevisiae Protein kinase, cyclic AMP dependent S. cerevisiae short artificial hairpins, inhibition by, inhibitors mutations, effect of, 5408 6841 catalytic (C.) subunit autoactivation PU.1 U5 small nuclear ribonucleoprotein threonine 197 phosphorylation, 2332 erythroblasts, immortalization of, 5670 particle protein, involvement of, DNA synthesis inhibition, 4477 multiprotein complex, component of 2959 Protein kinase inhibitors mouse Ig X2-4 enhancer, binding to, Pre-rRNA HIV LTR, inducible transcriptional acti- 6452 human vation of, 5245 PUB1 protein psoralen cross-linking to small nucleo- Protein kinases S. cerevisiae lar RNAs, 4382 casein kinase I-like polyadenylated RNA binding, 6102, Primer-DNA S. cerevisiae morphogenesis, required 6114 simian virus 40 for, 2870 Purine nucleotide synthesis genes DNA replication in vitro, formation Cdc2 chicken during, 2882 three-dimensional model, 5122 coexpression, 4784 Profilaggrin S. cerevisiae BCK1 and STEll epidermal calcium-binding protein, 613 tobacco NPK1 protein kinase, homol- QR1 gene Profilin ogy to, 4745 quail S. cerevisiae S. pombe Byr2 pp6OV', downregulation by, 3401 mutational analysis, 7864 tobacco NPK1 protein kinase, homol- v-src-responsive unit, novel, 3401 Prointerleukin 1 gene ogy to, 4745 Quail human tobacco NPK1 Pax-QNR proteins tissue-specific induction, 1332 yeast BCK1, STE11, and Byr2, ho- neuroretina, expression in, 7257 Proliferating cell nuclear antigen promoter mology to, 4745 QR1 gene human Protein phosphatase 2A pp60v^C, downregulation by, 3401 243-residue adenovirus ElA oncopro- AP-1-binding elements, potentiation of v-src-responsive unit, novel, 3401 tein, transactivation by, 1697 promoters containing, 2104 quartet developmental mutant Promoter mutagenesis S. cerevisiae D. melanogaster c-myc transcriptional elongation, use in dimorphism regulation, involvement bovine smg p25a GDP dissociation studying, 5647 in, 5567 inhibitor homolog, shift in isoelec- Pro-opiomelanocortin gene Protein S tric point of, 217 pituitary expression Gas6 protein, relation to, 4976 cell-specific helix-loop-helix factor, Protein tyrosine kinase Rabbit requirement for, 2342 activity, TCR associated a-globin gene Prostate epithelial cells TCR t, regulation by, 5771 nuclear protein-binding sites, 5439 Protein tyrosine kinases Rabphilin-3A rat smg p25A/rab3A p25 small GTP-binding exon switching, 4513 oncogene encoded protein FGF-FGF receptor genes, 4513 plasminogen activator gene expres- putative target protein, 2061 Protamine 2 mRNA sion, modulation of, 5888 RAD2 gene mouse Proto-oncogenes S. cerevisiae 3' untranslated region, phosphoprotein lungs, regulation of expression in, 3213 human ERCCS, homology to, 6393 binding to, 6547 PRP19 radl3 gene translation, repression of, 6547 S. cerevisiae S. pombe Protease 3C spliceosomal component, novel, 1876 human ERCCS, homology to, 6393 poliovirus spliceosome, association with, 1883 RAD23 gene human TATA-binding protein, direct U2, binding after, 1883 S. cerevisiae cleavage of, 1232 prp20-1 mutant ubiquitin-like domain, encoding of Protein kinase A S. cerevisiae protein with, 7757 nuclear entry GSP1 and GSP2 genetic suppressors, Raf-1 protein kinase rate limitation of stimulus-transcrip- 2152 human tion coupling through CREB, 4852 GTP-binding proteins involved in cell transformation, conditional, 6241 Protein kinase C maintenance of nuclear organiza- MAP kinase cascade, activation of, C3H 1OT1/2 fibroblasts tion, 2152 6241 signaling pathway distinct from but Pseudogene donor pool Raf-1 protein kinase activity interdependent with p21l" path- chicken regulation by tyrosine residues, 7170 way, 1471 germ line maintenance of, 821 X. laevis oocytes mammalian cDNA mutants somatic immunoglobulin gene conver- mos activity, 4197 classification by yeast phenotype, 4728 sion, 821 progesterone-induced maturation, 4197 mechanism of dioxin receptor-mediated Pseudoknots Raf-1-MEK-ERK signal transduction induction of cytochrome P-450IA1 viral 3' untranslated RNA pathway expression, 677 phylogenetically conserved sequence, reconstitution in vitro, 6615 a subspecies 5331 D-Raf NF-KB activation, blocking of, 4770 Psoralen D. melanogaster Protein kinase C phosphorylation sites cross-linking of small nucleolar RNAs to terminal signal transduction during ,-adrenergic agonists pre-rRNA, 4382 embryogenesis, 1163 requirement for enhanced response, Psoralen adducts Raf protein kinase 2391 xeroderma pigmentosum variant cells activation during mitogenic signal trans- c-src, cells overexpressing, 2391 defective replication, 1002 duction xxxiv SUBJECT INDEX MOL. CELL. BIOL.

Ras coupling by phosphatidylcholine vascular smooth muscle cells, down- Reblp hydrolysis, 7645 regulation in, 3722 K lactis RAG-1 gene with sequence homology to Droso- bipartite DNA-binding domain, 1173 immunoglobulin gene rearrangement phila hairy gene S. cerevisiae pre-B-cell lines, 3890 induction by factors known to influ- bipartite DNA-binding domain, 1173 RAG1 gene ence neuronal differentiation, 105 Receptor protein tyrosine phosphatase K lactis glucagon gene family hexokinase gene required for tran- CREB, transcription by, 7080 R-PTP-K, 2942 scriptional regulation, 3882 glutathione S-transferase Ya gene xeno- Receptor tyrosine phosphatases, new fam- RAG-2 biotic response element ily of immunoglobulin gene rearrangement C/EBP, regulation of function by, 4365 RPTP-y extracellular region pre-B-cell lines, 3890 dioxin receptor, regulation of function carbonic anhydrase-like domain, 1497 RAP1 by, 4365 Recombination S. cerevisiae growth hormone gene homologous and illegitimate TPI glycolytic gene expression, 543 ligand-dependent, Pit-1/GHF-1-inde- X laevis oocytes and eggs, 6897 Ha-Ras Asn-17 pendent stimulation, 1719 S. cerevisiae S. cerevisiae thyroid hormone receptors, stimula- mitotic, 3937 SDC25 C-domain gene product over- tion by, 1719 REG1 protein comes dominant inhibitory activ- heat shock protein 70 S. cerevisiae ity of, 39 expression altered by age and diet, ADH2, repression of expression of, ras gene 2909 4391 expression, down-regulation of HF-lb zinc finger protein Reifenstein syndrome cellular glutathione inhibitors, 4416 myosin light-chain 2 gene, binding to androgen receptor GTPase-activating protein element of, 4432 D box, mutation in, 7850 p2l' function, suppression of, 2420 kininogen family genes c-Rel protein plasma membrane targeted, 2420 hepatic expression, differential, 6766 TATA-binding protein, interaction with, inhibitors Mak protein kinase 6733 DNA synthesis inhibition, 4477 210-kDa cellular phosphoprotein, asso- TFIIB, association with, 6733 Ras protein ciation with, 4146 activation spermatogenesis, expression in, 4146 v-Rel protein platelet-derived growth factor, media- mitogen-activated protein kinase kinase TATA-binding protein, interaction with, tion by, 3706 MKK2, 4539 6733 insulin and epidermal growth factor, ac- MKK2 protein kinase kinase TFIIB, association with, 6733 tivation by characterization, 4539 rel proteins enhanced exchange of guanine nucleo- identification, 4539 DNA binding tides on p21l's, 155 myosin light-chain 2 gene pp40'"-O, differential inhibition by, S. cerevisiae HF-lb zinc finger protein, 4432 1769 CDC25, influence of guanine nucleo- HF-1b/MEF2 cardiac regulatory ele- p64, 6147 tides on complex formation with, ment, 4432 RelA(p65) 1345 osteocalcin gene NFKB2, dimerization with RAS proteins expression, inhibition of, 5907 IKB MAD-3, regulation of DNA bind- S. cerevisiae prostate epithelial cells ing, transcriptional activation, and adenylyl cyclase, action on, 769 exon switching, 4513 inhibition by, 1315 antibody mimicking action of, 769 FGF-FGF receptor genes, 4513 RelB Ras-cyclic AMP pathway T cell lymphoma lines full transactivation, requirement of both S. cerevisiae Gfi-J gene, 1759 N- and C-terminal motifs for, 1572 G, cyclin expression, connection with, IL-2 independence, progression to, N-terminal leucine zipper-like motif, 6274 1759 1572 Rat tissue type plasminogen activator gene Renal transcription factor, putative ADD1 DNA elements and nuclear factors Kid-I adipocyte determination and differenti- mediating constitutive and cyclic ischemia and toxic injury, regulation ation, 4753 AMP-induced expression, 266 in response to, 1933 helix-loop-helix transcription factor, troponin I slow gene ontogeny, regulation during, 1933 4753 cis-acting sequences, 7019 Replication origins adipocyte determination and differentia- vascular smooth muscle cells effect of deletion on chromosome stabil- tion Gax gene, down-regulation of, 3722 ADD1, association with, 4753 zinc finger proteins ity, 391 aldolase A gene HF-lb, 4432 Replication protein A skeletal muscle-specific induction, Rat-lA cells human 6469 quiescent ionizing radiation-induced phosphory- anterior pituitary-derived cell lines A&FosB, proliferative activation by, lation response, 7222 C-type natriuretic peptide gene pro- 4157 Replication-linked histone genes moter, 4077 RBP1 protein, mutant transcription, regulation of P-casein gene promoter S. cerevisiae histone H2A.X gene, difference of reg- DNA-binding proteins, regulation of rapamycin cytotoxicity, abrogation of, ulation of, 984 interaction with, 7303 6012 Repression module C-type natriuretic peptide gene promoter REB1 Egr-1 protein, 4556 anterior pituitary-derived cell lines, S. cerevisiae ret tyrosine kinase 4077 TPI glycolytic gene expression, 543 regulatory subunit RIa of cyclic AMP- fibronectin gene REB1 site dependent protein kinase A, fusion alternatively spliced exon, regulation S. cerevisiae with of, 5301 RNA polymerase I terminator, essen- thyroid tumor-specific transforming Gax gene tial component of, 649 sequence, 358 VOL. 13, 1993 SUBJECT INDEX xxv

Retinoblastoma gene product E2F RFX1 RNA polymerase II genes human papillomavirus type 16 E7 pro- enhancer factor C, identity with, 6375 T. brucei tein, interaction with, 953 transactivation function largest subunit, 3734 Retinoblastoma protein HBV enhancer, 6375 RNA polymerase III E2 promoter repression, 3384 RFX protein human Alu repetitive elements, tran- E2F transcription factor, interaction methylated DNA-binding protein, 6810 scription of with, 3384 rho GDI adenovirus type 5, activation by, 3231 E2F transcription factors, binding to, cell motility, involvement in, 72 transcription 7813 rho p21 TATA-binding protein and associated E2F-1, direct binding to cell motility, involvement in, 72 factors, 7953 transactivation, inhibition of, 6501 Rhodotorula hasegawae transcription complexes, orientation and E2F1 gene, regulation of, 6314 U2 snRNA gene topography in, 942 growth suppression, pRB mediated, 3384 mRNA-type intron, 5613 RNA polymerase III transcription nuclear localization signal, bipartite, Ribosomal DNA Epstein-Barr virus EBER 2 gene 4588 S. cerevisiae upstream basal promoter element, im- overproduction cis-acting components in replication portance of, 2655 G2 arrest, 6640 origin, 5360 RNA polymerase I-defective mutants specific enzymatic dephosphorylation, Ribosomal gene promoter S. cerevisiae 367 mouse nucleolus, structural alterations in, Retinoic acid initiation complex formation, function 2441 axis formation in frog embryogenesis, of TIF-IA in, 6723 RNA polymerases mediation of Ribosomal protein Li transcription thyroid hormone receptor, modulation S. cerevisiae, requirement for S. cerevisiae a2 protein, repression by, 7540 5S rRNA, stability of newly synthe- by, 4029 HLH-octamer activation of CT/CGRP sized, 2835 RNA pseudoknots enhancer, repression of, 6079 60S ribosomal subunits, assembly of, translation, ribosomal pausing during, mouse GATA-4 induction, 2235 2835 6931 9-cis Retinoic acid Ribosomal protein L21 RNA-processing reactions rat osteocalcin gene expression, stimula- chloroplast T. brucei tion of, 5907 developmental regulation of a house- temporal order, 720 Retinoic acid and interleukin-6 signalling keeping gene by alternative pro- trans splicing preceding polyadenyla- convergent regulation of Oct-1 and NF- moters, 2614 tion, 720 IL6 synthesis, 2515 nuclear gene, 2614 Roxl protein Retinoic acid receptor 1-retinoid X recep- Ribosomal protein S6 gene S. cerevisiae tor ,B heterodimers D. melanogaster DNA binding, 6071 involvement in retinoic acid induction of mutations causing tissue overgrowth, HMG motif, 6071 MHC class I genes, 6157 2524 RPTPy Retinoic acid receptors RNA 3-end formation carbonic anhydrase-like domain in extra- ninth C-terminal heptad, 5725 sequences in last intron, function of, cellular region Retinoic acid response element 3359 receptor tyrosine phosphatases, new mouse Hox-4.2 gene, upstream of, 257 RNA editing family of, 1497 Retinoid A receptor apolipoprotein B mRNA, 7288 R-PTP-K erbA, repression of action by, 5970 RNA polymerase I receptor protein tyrosine phosphatase Retinoid X receptor S. cerevisiae family, new member of, 2942 erbA, repression of action by, 5970 A12.2 subunit, 114 RRM-type RNA-binding protein genes homodimer formation RRN4, 114 relatedness analyzed by numerical ap- T3 response, repression of, 7698 RNA polymerase I enhancer proach, 174 Retinoid X receptor K S. cerevisiae RRN4 estrogen-responsive gene activation in vitro definition, 2644 S. cerevisiae multiple inhibitory pathways, 2258 RNA polymerase I terminator RNA polymerase I A12.2 subunit, 114 Retinoid X receptors S. cerevisiae rRNA enhancer rat osteocalcin gene expression, stimula- REB1 site is an essential component, S. cerevisiae tion of, 5907 649 rRNA transcription, regulation of, Retinoid receptor complexes RNA polymerase II 1283 DNA bending, 6509 D. melanogaster rRNA genes Retroposition two large subunits, mutations in genes D. melanogaster carcinoma-associated antigen genes, encoding, 4214 phorbol ester and serum, stimulation 1507 S. cerevisiae by, 934 Retroviral vectors RPB4 subunit essential for stress re- human alkaline phosphatase sponses, 6984 DNA replication initiation and termi- spatial restriction of viral gene expres- termination and pausing, 5159 nation, 6600 sion/transduction in the chick em- TFIIB interactions, potential induction rRNA processing bryo, 2604 of, 6253 pre-5.8S Rev protein transcription S. cerevisiae, 7935 HIV-1 initiation and reinitiation rates, 4572 rRNA transcription, in vivo regulation of pre-mRNA, function with respect to, TATA-binding protein and associated D. melanogaster 6180 factors, 7953 phorbol ester and serum, response to, Rev-ErbAa orphan receptor RNA polymerase II elongation complexes, 928 transcription activation, 3113 termination competent runt homology domain Rex-1 gene generation human F9 teratocarcinoma cells, expression in 3' RNA processing efficiency, role in, AML-1 protein, 6336 octamer motif, contribution of, 2919 3472 AML-1/ETO protein, 6336 xxxvi SUBJECT INDEX MOL. CDELL. BIOL.

Rvs167 protein dbf4, suppressor gene of, 4445 dbf4 gene S. cerevisiae Cdc7 protein kinase CDC5 is suppressor gene, 4445 alteration, results of, 5070 cell cycle regulation, 2899 Dbf4 protein Dbf4 protein, association with, 2899 Cdc7 protein kinase, association with, S6 ribosomal protein gene cdcl5 mutants 2899 D. melanogaster anaphase, arrest in, 4953 dimorphism, regulation of mutations causing tissue overgrowth, rescue by Xenopus cDNAs, 4953 Elmlp, involvement of, 5567 2524 CDC25 protein phosphatase 2A, involvement s36 chorion gene Ras, influence of guanine nucleotides of, 5567 D. melanogaster on complex formation with, 1345 DNA polymerase mutation oogenesis, follicular expression dur- Cdc28 segregation bias ofARS plasmid, sup- ing, 5898 Cln3, activation by, 3266 pression of, 1489 Saccharomyces cerevisiae Cdc28 protein kinase complexes DNA polymerases a and 8 5'-3' exonuclease mating pheromone signal transduction DNA polymerases e, influence on, in vitro recombination, requirement pathway, 5659 1051 in, 3125 Cdc68 protein DNA repair synthesis during base ex- 5'-*3' exonuclease 1-lacking cells Sanl, antagonism by, 7553 cision repair, 1051 mRNA species, 4826 cell cycle blockage DNA polymerases e ADA3 gene heat shock mediated, 1034 DNA polymerases a and 8, influence ADA2 gene, similarity to, 5981 CIHA promoter of, 1051 GAL4-VP16 resistance, 5981 regulatory element, 7604 DNA replication, 5112 ADH2 gene chimeric VP16-estrogen receptor DNA topoisomerase I REG1, repression of expression by, cell growth arrest, 462 DNA topology, 6702 4391 estradiol-inducible squelching, 462 promoter activation, 6702 ADR1 protein PDRI allele, suppression of effects by, DNA topoisomerase II mutants phosphorylation, 4391 462 meiosis-specific arrest, 3445 AFR1 protein chromosomal replication DRS1 to DRS7 genes adaptation, promotion of, 6876 DNA polymerases 8 and e, require- ribosome assembly and function, re- morphogenesis, promotion of, 6876 ment for, 496 quired for, 7901 x-agglutinin cell adhesion protein chromosome VI early meiotic upstream activation se- cell surface anchorage and ligand- autonomously replicating sequences, quence binding domains, 2554 5043 bipartite structure, 2172 immunoglobulin superfamily member, chromosome segregation eIF-2 2554 CSEI and CSE2, 4691 guanine nucleotide exchange factor, at protein chromosome segregation, mitotic 1920 DNA sequence requirements for activ- PLCl, 4351 eIF-2 y subunit ity of, 6866 clathrin-deficient strains GCD11, 506 a2 protein overexpression of ubiquitin, rescue Elmlp protein transcription, repression of, 4029 by, 521 dimorphism regulation, involvement a-specific genes CLN2 gene expression in response to in, 5567 transcription, 6866 mating pheromone EN02 amino acid import FAR1, posttranscriptional regulation GCR1-dependent transcriptional acti- FK506, inhibition by, 5010 by, 1013 vation, complex regulatory ele- arginine metabolism regulation Cln3 ment modulating, 2623 MCM1, role of, 2586 Cdc28 activation, 3266 eukaryotic translation initiation factor 2 ARS plasmid, segregation bias of cmdl-l GCN1 required for phosphorylation by DNA polymerase mutation, suppres- calmodulin mutant, temperature sensi- GCN2, 3541 soin by, 1489 tive, 1779 guanine nucleotide exchange factor, artificial chromosomes suppressor related to fork head family 4618 use in studying human BCL2 expres- of DNA-binding proteins, 1779 a-factor receptor sion, 5469 conditional silencing adaptation, promotion of, 6876 autonomously replicating sequences HMRE mating-type silencer, 727 morphogenesis, promotion of, 6876 chromosome VI, 5043 conditional viability FAR1 B-type cyclins Rvs167 mutation, result of, 5070 CLN2 gene expression in response to mitosis and meiosis, differential func- COT2 gene mating pheromone, posttranscrip- tion and expression in, 2113 glucose-dependent divalent cation tional regulation of, 1013 budding pattern defects transport, requirement for, 2041 Farl protein result 5070 COX3 mRNA mating pheromone signal transduction Rvs167 mutation, of, defect, suppression of, 4806 pathway, 5659 BUF protein CSEI gene farnesyltransferase and geranylgeranyl- binding, 5749 chromosome segregation, 4691 transferase-I calmodulin CSE2 gene cross-specificity, 4260 essential mitotic target, 7913 chromosome segregation, 4691 FLP recombinase calmodulin mutant, temperature sensi- CYCI mRNA cleavage and ligation, mechanism of, tive signals that produce 3' termini, 7836 3167 suppressor related to fork head family CYC2 gene mutations, classification of, 3167 of DNA-binding proteins, 1779 protein product, 6442 Fus3 protein CAP cyclase-associated protein mating pheromone signal transduction adenylyl cyclase mutants, 4087 adenylyl cyclase mutants, 4087 pathway, 5659 CBFSp cytochrome c G, cyclin expression centromeres, binding to, 4884 mitochondrial import, 6442 heat shock mediated, 1034 microtubules, binding to, 4884 cytoskeletal defects Ras-cAMP pathway, connection with, CDC5 gene Rvs167 mutation, result of, 5070 6274 VOL. 13, 1993 SUBJECT INDEX xxxvii

G1/S-specific transcription putative membrane protein, encoding function in, 3076 SWI4/SWI6 protein complex, 1069 of, 4039 morphogenesis, requirements for G protein subunits SKNI, functional homolog of, 4039 casein kinase I-like protein kinases, interactions involved in mating, 1 KRE9 gene YCKI and YCK2 encoded, 2870 GAL4 gene 0 glycoprotein involved in ,B-glucan Mpklp weak expression, promoter elements assembly, 6346 protein kinase signaling, mediation of, determining, 4999 Li ribosomal protein, requirement for 3067 Gal80 protein SS rRNA, stability of newly synthe- mRNA decay galactose regulon, glucose repression sized, 2835 AL4Tad transcript, promotion by, 5141 of, 7566 60S ribosomal subunits, assembly of, v-Myb and c-Myb transcriptional activa- K lactis Gal80, conservation with, 2835 tion 7566 Leu3 protein animal cells, comparison with, 4423 GAL genes functions, 5702 NAB2 TSF3, silencing by, 831 MAG and MGT1 genes cell viability, essential for, 2730 GCD6 and GCD7 transcriptional regulation, common NF-KB p50 and p65 subunits eIF-2 guanine nucleotide exchange element in, 7213 concentration of transcriptional activa- factor, subunits of, 1920 AM Tod transcript tion functions in mammalian cells, GCN1 mRNA decay, promotion of, 5141 1666 eukaryotic translation initiation factor AMTed transcription nonhomologous transforming DNA 2 phosphorylation, required for, Ste signal transduction pathway for integration into chromosomes, 2697 3541 mating pheromones, 2050 ligation to mitochondrial DNA in vivo, GCN2 protein kinase mating 2697 activation, 5099 G protein subunits, interactions nuclear ribosomal DNA GCN4 gene among, 1 P. polycephalum mobile group I in- GCD6 and GCD7, translational regula- mating pheromone signal transduction tron, insertion of and induction of tion by, 1920 pathway, 5659 point mutations by, 1023 translation, stimulation of, 5099 MCM1 nuclear RNase MRP GCN4 protein arginine metabolism, regulation of, pre-5.8S rRNA processing, required unusual activation site interspersed 2586 for, 7935 with complex transcriptional re- SPT13 (GAL11), regulation of activity nucleolus pression site in Ty2 elements, in Tyl elements by, 63 structural alterations in mutants defec- 2091 Tyl, binding to transcriptional control tive in RNA polymerase I, 2441 GCR1 element in, 57 p34CDC28 histone Hi kinase TPI glycolytic gene expression, 543 meiosis, timing of molecular events in activation, 3744 genomic instability formation of stable heteroduplex DNA p34CDC28 kinase activity inverted DNA repeats, 5315 late in meiotic prophase, 373 elevation, 5112 glucose transporters, multiple meiosis-specific arrest p60V

prp20-1 mutant Rvs167 protein tivators REB1, RAP1, and GCR1 GSP1 and GSP2 genetic suppressors, alteration, results of, 5070 in high-level expression, 543 2152 Sanl protein TSF3 global regulatory protein GTP-binding proteins involved in Cdc68, antagonism of, 7553 a2 repressor, mediator of repression maintenance of nuclear organiza- SDC25 C-domain gene product by, 831 tion, 2152 Ha-Ras Asn-17, overcoming of domi- GAL genes, silencing of transcription PTCI gene nant inhibitory activity of, 39 of, 831 mutations, effect of, 5408 SIN3-LexA fusion protein SIN4, identical to, 831 PTP2 gene transcriptional repression, 1805 TTAGGG repeat-binding protein, essen- mutations, effect of, 5408 SKI antiviral system tial gene encoding, 1306 PUB1 protein viral mRNA expression, blockage of, Ty2 polyadenylated RNA binding, 6102, 4331 interspersion of unusual GCN4 activa- 6114 SKMN gene tion site with complex transcrip- RAD2 gene KRE6, functional homolog of, 4039 tional repression site, 2091 human ERCC5, homology to, 6393 putative membrane protein, encoding repression of transcription by three RAD23 gene of, 4039 downstream sites, 2081 ubiquitin-like domain, encoding of small nucleolar RNA Ul small nuclear ribonucleoprotein par- protein with, 7757 snR30, 2469 ticle-protein interactions RAP1 SNF1 protein kinase mutant in vivo competition assays, 2126 TPI glycolytic gene expression, 543 zinc finger genes, homologous, 3872 U5 small nuclear ribonucleoprotein par- Ras snR30 ticle protein CDC25, influence of guanine nucleo- 18S rRNA synthesis, requirement for, pre-mRNA splicing, involvement in, tides on complex formation with, 2469 2959 1345 spindle pole body U6 RNA gene promoter RAS proteins 110-kDa component, 7913 architecture, 3015 adenylyl cyclase, action on, 769 SPKI gene ubiquitin, overexpression of antibody mimicking action of, 769 nuclear Ser/Thr/Tyr kinase, encoding clathrin-deficient strains, rescue of, Ras-cAMP pathway of, 5829 521 G1 cyclin expression, connection with, S-phase specificity, 5829 use for analysis of c-Src activity, 5290 6274 splicing signals YCKI RBP1 protein, mutant short artificial hairpins, sequestration encodes protein kinase required for rapamycin cytotoxicity, abrogation of, by, 6841 morphogenesis, 2870 6012 SPT2 suppressor alleles, dominant YCK2 REB1 mutational and functional analysis, encodes protein kinase required for TPI glycolytic gene expression, 543 5393 morphogenesis, 2870 REBM site SPT13 (GAL11) YLpFAT10 linear plasmid RNA polymerase I terminator, essen- MCM1 transcription factor activity in origin activation, 4057 tial component of, 649 Tyl elements, regulation of, 63 single-strand TG1_3 tails, formation of, Reblp squalene synthetase 4057 bipartite DNA-binding domain, 1173 human and S. pombe squalene syn- YME1 gene recombination thetases, similarities to, 2706 inactivation, effect of, 5418 mitotic, 3937 STDI zinc finger genes REG1 protein TATA-binding protein mutation, sup- SNF1 protein kinase mutant, 3872 ADH2, repression of expression of, pression of, 3650 Sanl protein 4391 STE12 S. cerevisiae ribosomal DNA functional domains, 3765 Cdc68, antagonism of, 7553 cis-acting components in replication SUP45 Sarcophaga peregrina origin, 5360 X laevis developmentally regulated 59-kilodalton protein RNA polymerase I mRNA product, homology to, characterization, 4049 A12.2 subunit, 114 2815 defense protein gene NF-KB-binding RRN4 gene, 114 SW74 motifs, binding to, 4049 RNA polymerase I enhancer SW16-dependent cis-acting elements, purification, 4049 in vitro definition, 2644 transcription control by, 3792 Satellite tobacco necrosis virus RNA polymerase I terminator SW14/SWI6 protein complex 3' untranslated region REB1 site is an essential component, G,/S-specific transcription, 1069 translation in vitro, stimulation of, 649 SWI5 protein 3340 RNA polymerase II GRF10 protein, cooperative DNA Schizosaccharomyces pombe RPB4 subunit essential for stress re- binding with, 5524 centromeres sponses, 6984 TAPI gene variability, 4578 termination and pausing, 5159 tRNA gene expression, activation of, cyclins, B-type RNA polymerase I, mutants defective in 3424 Cig2 and Cdc13, 2286 nucleolus, structural alterations of, TAP1 protein mitosis, different functions in, 2286 2441 structure, 3434 fipl+ gene Roxl protein TIF4631 gene ferric iron uptake, required for, 4342 DNA binding, 6071 essential function, 4860 gp91-phox subunit of human NADPH HMG motif, 6071 RNA recognition motif-like sequence, phagocyte oxidoreductase gene, RRN4 4860 homology to, 4342 essential only at high temperatures, TIF4632 gene heat shock factor 114 essential function, 4860 requirement for growth at normal tem- RNA polymerase I A12.2 subunit, 114 RNA recognition motif-like sequence, peratures, 749 rRNA enhancer 4860 map3' rRNA transcription, regulation of, TPI glycolytic gene putative M-factor receptor, 80 1283 concerted action of transcriptional ac- radl3 gene VOL. 13, 1993 SUBJECT INDEX xxxix

human ERCC5, homology to, 6393 ps6Ick SIN4 Spkl protein stable Tyr-505 phosphorylation, role S. cerevisiae, 831 tyrosine phosphorylation, 6427 in, 7112 TSF3, identical to, 831 X. laevis MAP kinase, relationship to, phosphatidylinositol 3-kinase Skeletal and cardiac muscle 6427 in vivo binding properties, 1737 creatine kinase-M gene squalene synthetase Src protein control of expression, 1264 human and S. cerevisiae squalene syn- phosphopeptides, binding to, 7278 Skeletal muscle thetases, similarities to, 2706 tyrosine-phosphorylated peptides, high- muscle creatine kinase enhancer activity SRP54 protein assembly with signal rec- affinity binding to, 1449 multiple regulatory elements, differen- ognition particle RNA tyrosine-phosphorylated platelet-derived tial contributions of, 2753 RNA sequences and structural ele- growth factor ,-receptor sequences, transgenic mice, ectopic formation in ments required, 1353 interactions with bovine myfS expression, induced by, scid thymocytes biosensor-based approach, analysis 6044 mouse by, 3567 SKI antiviral system T-cell receptor 8 element recombina- SH3 domain S. cerevisiae tion, 3632 p561ck viral mRNA expression, blockage of, SDC25 C-domain gene product binding to PI 3-kinase but not PI 4-ki- 4331 S. cerevisiae nase, 7708 SKN1 gene Ha-Ras Asn-17, overcoming of domi- PI 3'-kinase, binding to, 7408 S. cerevisiae nant inhibitory activity of, 39 v-Src protein KRE6, functional homolog of, 4039 Sea urchin PI 3'-kinase, binding to, 5225 putative membrane protein, encoding P3A2 protein Signal transduction of, 4039 protein encoded by D. melanogaster fibroblast growth factor receptor kinase, Slp gene erect wing gene, similarity to, 3907 mouse 3641 Signal transduction pathways enhancer, 6326 Sea urchin embryo cross-coupling, 677 Small cytoplasmic Alu RNA metallothionein spMTA gene induction of cytochrome P-450IA1 multiple dispersed loci, production by, promoter and intron 1 regions, combi- expression by dioxin receptor, 677 4233 natorial regulation by, 993 Raf-1-MEK-ERK Small nuclear ribonucleoprotein particles E-Selectin promoter reconstitution in vitro, 6615 Ul activation S. cerevisiae in vitro splicing, 3135 cAMP-independent ATF family pro- mating pheromone, 5659 uncoupling of two functions, 3135 teins, function of, 7180 Signaling activity Small nuclear ribonucleoprotein U2 Serine/threonine protein kinase TGF-3 additional proteins, numerous, 307 phosphoinositide 3-kinase activity, regu- type II receptors, 7239 bipartite structure under splicing condi- lation by, 1657 Signaling pathway 307 Serine/threonine protein kinase gene family branched tions, sgk novel member nerve growth factor, 3146 Small nuclear RNA glucocorticoids and serum, transcrip- Simian virus 40 T. brucei tional induction by, 2031 core origin inverted repeat domain fibrillarin and pre-mRNAs, 144 Serum growth factors sequence-specific single-stranded major nucleolar trimethylguanosine- nur77 gene, activation of, 6124 DNA-binding factor, cell cycle- capped snRNA, 144 Serum response factor regulated binding of, 408 RNA B, 144 inhibitory domains, 4640 DNA replication Ul phosphorylation by pp9()k, 6260 HeLa cell nuclear kinase casein kinase pre-mRNA splicing, promotion of per- transcriptional activation domain, 4640 I, 1202 manent changes in, 2666 Serum response factor-binding elements DNA replication initiation stable expression in mammalian cells, NF-KB, interaction with specific domain of human DNA poly- 2666 interleukin-2 receptor oa-chain en- merase a interaction with large T U6 hancer activation, 2536 antigen, requirement for, 809 ACAGAGA and AGC sequences, 5377 T lymphocytes, 2536 DNA replication in vitro Small nuclear RNA genes Sex-lethal gene primer-DNA formation, 2882 U2 D. melanogaster integration into cellular DNA R. hasegawae, 5613 autoregulation, 7734 topoisomerase II cleavage hot spots, U6, human Sex-lethal male exon 6190 distal control region, 4670 D. melanogaster large T antigen Small nucleolar RNA regulated splicing involving blockage interactions with multiple components S. cerevisiae mechanism, 1408 of the transcription complex, 961 SF2/ASF 18S rRNA synthesis, requirement for, human transcriptional activation by, 961 2469 exon skipping and inclusion, modula- minichromosomes snR30, 2469 tion of, 2993 nucleosome assembly factor, 1059 Small nucleolar rRNAs sgk ori-dependent DNA replication human serine/threonine protein kinase gene IgH enhancer elements, regulation by, psoralen cross-linking to pre-rRNA, family, novel member of 5629 4382 glucocorticoids and serum, transcrip- T antigen Small subunit rRNA gene tional induction by, 2031 MDM2 protein, binding to, 6849 T. thennophila Sgs-4 and Pig-i genes T-antigen amino-terminal mutant targeted mutations, 4814 D. melanogaster transgenic mice, cell-specific transfor- smg p25a GDP dissociation inhibitor, bo- transcriptional switch, 184 mation in, 3255 vine SH2 domain SIN3-LexA fusion protein D. melanogaster homolog GTPase-activating protein S. cerevisiae quartet developmental mutant, iso- in vivo binding properties, 1737 transcriptional repression, 1805 electric point shift in, 217 xl SUBJECT INDEX MOL. CELL. BIOL. smg p25A/rab3A p25 small GTP-binding SPT13 (GAL11) progression, changes in, 3577 protein S. cerevisiae Sterol-regulated genes rabphilin-3A, putative target for, 2061 MCM1 transcription factor activity in hamster synaptogamin, relationship to, 2061 Tyl elements, regulation of, 63 transcriptional activation, loss of, 5175 SNF1 protein kinase Squalene synthetases Stimulus-transcription coupling S. cerevisiae human, S. cerevisiae, and S. pombe CREB mutant, 3872 similarities among, 2706 rate limitation, 4852 zinc finger genes, homologous, 3872 SR proteins STPK13 mRNA snR30 small nucleolar RNA human, 4023 mouse S. cerevisiae c-src protein kinase, mitotic, 7793 18S rRNA synthesis, requirement for, cells overexpressing regulation, 7793 2469 13-adrenergic agonists, enhanced re- SUP45 SNT sponse to, 2391 S. cerevisiae neurotrophic factor-induced tyrosine ki- Src peptide X. laevis developmentally regulated nase NH2-terminally myristylated mRNA product, homology to, differentiation-specific target, 2203 ADP/ATP carrier is 32-kilodalton re- 2815 neurons and PC12 cells, 2203 ceptor, 3084 5174 Somatic cell hybrids Src protein S. cerevisiae -y- to 3-globin gene switching SH2 domain SW16-dependent cis-acting elements, serum factors, modulation of develop- phosphopeptides, binding to, 7278 transcriptional control by, 3792 mental clock by, 4844 c-Src protein SWI4/SWI6 protein complex Somatic immunoglobulin gene conversion C-terminal Src kinase, suppression of S. cerevisiae chicken activity by G,/S-specific transcription, 1069 pseudogene donor pool, germ line involvement of c-Src SH2 and SH3 SWIS protein maintenance of, 821 domains, 5290 S. cerevisiae Species-specific signals S. cerevisiae, analysis with, 5290 GRF10 protein, cooperative DNA short intron, splicing of SH2 domain binding with, 5524 D. melanogaster, 1104 involvement in suppression of c-Src Sperm activity, 5290 T antigen angiotensin-converting enzyme (ACE), SH3 domain SV40 specific expression of involvement in suppression of c-Src MDM2 protein, binding to, 6849 91-base-pair promoter containing activity, 5290 T cell lymphoma lines, rat CRE-like element, 18 v-Src protein IL-2 independence, progression to Sperm tail proteins, conserved SH3 domain Gfi-1 gene, 1759 D. melanogaster PI 3'-kinase, binding to, 5225 T cell receptor alpha-chain gene gene duplication, translational regula- c-src tyrosine protein kinase murine somatic cell hybrids tion of, 1708 CD45 tyrosine protein phosphatase extinction accomplished by loss of manchette tyrosine phosphorylation, 1651 lymphoid enhancer-binding factor Spermatid SRP54 1, 1943 microtubules S. pombe T cell receptor-,B Ser/Thr protein kinase, novel, 7625 signal recognition particle RNA, as- mRNA splicing Spermatids sembly with, 1353 unusual splicing intermediates, regula- mouse SRp75 tion of, 1686 nuclear high-mobility-group box pro- human T cells teins, 4323 cDNA encoding, 4023 CD4 enhancer activity Spindle pole body SSAP-1 regulation, 5620 S. cerevisiae stage-specific embryonic enhancer-bind- T cells, activated 110-kDa component, 7913 ing protein, 1746 NFAT-1 DNA binding complex SPK1 gene STD1 Fra-1 and JunB, 1911 S. cerevisiae S. cerevisiae T cells, primary nuclear Ser/Thr/Tyr kinase, encoding TATA-binding protein mutation, sup- human of, 5829 pression of, 3650 E2F, cell cycle analysis of, 3975 S-phase specificity, 5829 STE12 TALl oncoprotein Spkl protein S. cerevisiae ERK1 protein kinase S. pombe functional domains, 3765 extracellular signal, regulation by, 801 tyrosine phosphorylation, 6427 Ste signal transduction pathway for mating phosphorylation by, 801 X. laevis MAP kinase, relationship to, pheromones TAP1 gene 6427 S. cerevisiae S. cerevisiae AL4Tal transcription, 2050 activation Spliceosomal component, novel Stem cell factor tRNA gene expression, of, S. cerevisiae Kit binding site 3424 PRP19, 1876 molecular chimeras, 2224 TAP1 protein Spliceosome Steroid 21-hydroxylase gene S. cerevisiae U6 small nuclear RNA NGFI-B, regulation by, 861 structure, 3434 3' end modifications, 1641 Steroid antagonists TAR RNA-binding protein TRBP Splicing signals cyclin gene expression, regulation of human immunodeficiency virus type 1 S. cerevisiae T47D human breast cancer cell cycle Drosophila Staufen, relatedness to, short artificial hairpins, inhibition by, progression, changes in, 3577 2193 6841 Steroidogenic factor 1 human P1/dsI kinase, relatedness to, SPT2 suppressor alleles, dominant monomer binding to DNA, 5794 2193 S. cerevisiae Steroids TATA box-binding polypeptide mutational and functional analysis, cyclin gene expression, regulation of human 5393 T47D human breast cancer cell cycle p53 activation domain, binding to, VOL. 13, 1993 SUBJECT INDEX xli

3291 26S rRNA, alternative helix in, 1137 AMP-induced expression, 266 TATA element, sequences downstream of excision and integration, 1137 Tobacco protein-DNA complex containing TATA- small subunit rRNA gene NPK1 gene binding protein, contribution to, targeted mutations, 4814 protein homologous to yeast protein 2593 telomerase kinases, 4745 TATA-binding protein polymerization activity, 6586 Topoisomerase II protein-DNA complex TFEC cleavage hot spots, VM26 induced sequences downstream of TATA ele- TFE3, heterodimer formation with, 4505 SV40 integration into cellular DNA, ment, contribution of, 2593 TFE3-dependent transcription activa- 6190 c-Rel and v-Rel, interactions with, 6733 tion, inhibition of, 4505 D. melanogaster RNA polymerase II and polymerase III TFIIB 87A7 heat shock locus, redistribution transcription, 7953 RNA polymerase II-induced interac- in, 7522 Tcl transposon tions, potential, 6253 Torso C. elegans TFIIIA D. melanogaster myosin light chain gene, site-selected proteolytic footprinting terminal signal transduction during insertion into, 902 5S RNA and SS DNA, tightly binding embryogenesis, 1163 T-cell receptor sites for, 5149 TPI glycolytic gene ( subunit X. laevis S. cerevisiae protein tyrosine kinase activity, regu- transcription-activating domain, 7496 concerted action of transcriptional ac- lation of, 5771 zinc fingers tivators REB1, RAP1, and GCR1 tyrosine phosphorylation, 5771 X. laevis embryos, function in, 4776 in high-level expression, 543 T-cell receptor enhancer Thymidylate synthase gene Transcription complexes TCF13 protein, binding to, 5450 mouse RNA polymerase III, orientation and T-cell receptor enhancer growth-regulated expression, need of topography of, 942 core-binding factor introns for, 1565 Transcription factor IIB subunits, cloning and characterization Thymidylate synthase promoter, TATA- c-Rel and v-Rel, interactions with, 6733 of, 3324 less Transcription factor IID T-cell receptor gene expression mouse D. melanogaster novel CACCC-binding protein, regula- initiator element, lack of, 4894 85-kDa subunit, 7859 tion by, 5691 multiple transcriptional initiation sites, promoter DNA, binding to TCF,13 protein 4894 near-zero linking difference, 1872 TCR enhancer, binding to, 5450 Thyroid hormone receptor Transcription initiation and reinitiation Telomerase axis formation in frog embryogenesis, RNA polymerase II, 4572 T. thennophila modulation of, 7540 Transcriptional activation polymerization activity, 6586 Jun herpes simplex virus Telomere repeat sequences action, modulation of, 3042 Vmw65 acidic domain, 5233 acquisition by transfected DNA inte- ninth C-terminal heptad, 5725 inducible grated at the site of a chromosome rat growth hormone gene HIV LTR, 5245 break, 977 ligand-dependent, Pit-1/GHF-1-inde- loss Telomere-associated repeat units, complex pendent stimulation, 1719 hamster sterol-regulated genes, 5175 Chironomus, members of genus Thyroid hormone receptor complexes Transcriptional elongation evolution from sequences similar to DNA bending, 6509 c-myc gene simple telomeric repeats, 1583 Thyroid hormone response distinct properties in different cell Telomeric DNA repeat RXR homodimer formation, repression types, 5647 human due to, 7698 Transferrin promoter nuclear proteins, binding to, 4301 Thyroid hormone response elements C/EBP-binding site, 7666 Telomeric repeats HIV-1 Transformation C. albicans LTR, 5057 Fos proteins unusually large, 551 Thyroid tumor-specific transforming se- transactivation domain, requirement Template titration quence for, 7429 c-myc transcriptional elongation, use in ret tyrosine kinase fusion with regula- Transformation gene studying, 5647 tory subunit RIa of cyclic AMP- Gal2 gene product, 762 Teniposide dependent protein kinase A, 358 Transforming growth factor alpha topoisomerase II cleavage hot spots, in- Thyrotropin transgenic mouse pancreas and liver duction of DNA synthesis, stimulation of oncogene-induced carcinogenesis, en- SV40 integration into cellular DNA, inhibition, 4477 hancement of, 320 6190 TIF4631 gene Transforming growth factor 1 Terminal deoxynucleotidyltransferase gene S. cerevisiae interleukin-2 gene, inhibition of inducible mouse essential function, 4860 activity of Ets protein interaction with critical RNA recognition motif-like sequence, noncanonical octamer-binding site, promoter element, 2982 4860 1155 LyF-1 interaction with critical pro- TIF4632 gene type II receptors moter element, 2982 S. cerevisiae signaling activity, 7239 12-O-Tetradecanoylphorbol-13-acetate essential function, 4860 Transforming growth factor ,1 heme oxygenase expression, mediation RNA recognition motif-like sequence, expression, control of of induction of 4860 GC-rich domain, 3588 myelomonocytic cell lines, 7881 TIF-IA Transgenic mice Tetrahymena thernophila initiation complex formation, function ectopic skeletal muscle formation high-mobility-group-like protein in, 6723 bovine myf5 expression, induced by, targeting to micronuclei in cell cycle- Tissue type plasminogen activator gene 6044 dependent and developmentally rat fiber type specificity regulated fashion, 163 DNA elements and nuclear factors rat TnIslow gene cis-acting sequences, intervening sequence mediating constitutive and cyclic conferred by, 7019 xlii SUBJECT INDEX MOL. CELL. BIOL.

human CD4 capped snRNA, 144 Tyrosine kinase signaling pathways tissue-specific expression of, 2952 RNA B, 144 immediate early genes human -y-globin genes, developmental ubiquitin extension protein 52 gene attenuation of serum inducibility by regulation of, 7636 EF-hand 5 protein and calmodulin oncoproteins, 2011 keratin 18 gene genes, genomic and transcrip- Tyrosine phosphatase/kinase signaling cas- cis regulation, 1815 tional linkage with, 207 cade keratin 18 gene, human variant surface glycoprotein gene gamma interferon activation, 1634 transcriptional insulation, 2214 expression site promoter, putative Tyrosine-phosphorylated peptides transcriptional insulation, Alu involve- upstream retroposon-like sequence, SH2 domains, high-affinity binding to, ment in, 6742 7036 1449 metallothionein locus distal regulatory TSF3 global regulatory protein elements S. cerevisiae Ul small nuclear ribonucleoprotein particle gene expression, stimulation of, 5266 ax2 repressor, mediator of repression in vitro splicing, 3135 pancreas and liver, oncogene-induced by, 831 uncoupling of two functions, 3135 carcinogenesis in GAL genes, silencing of transcription Ul small nuclear ribonucleoprotein parti- transforming growth factor alpha, en- of, 831 cle-protein interactions hancement by, 320 SIN4, identical to, 831 S. cerevisiae transferrin promoter tsHMG gene in vivo competition assays, 2126 C/EBP-binding site, 7666 mouse Ul small nuclear RNA transformation, cell specific nuclear high-mobility-group box pro- altered specificity simian virus 40 T-antigen amino-termi- tein, 4323 pre-mRNA splicing, promotion of per- nal mutant, 3255 TTAGGG repeat-binding protein manent changes in, 2666 V(D)J recombination S. cerevisiae stable expression in mammalian cells, CpG methylation, influence of, 571 essential gene encoding, 1306 2666 target spacing, influence of, 571 Tubulin Ul small nuclear RNA gene Transmembrane protein tyrosine kinases T. brucei D. melanogaster C. elegans, 7133 trans splicing preceding polyadenyla- transcription in vitro, requirements Triosephosphate gene tion, 720 for, 5918 human a- and P-Tubulin U2 locus, artificial RNA 3'-end formation, function of folding human last-intron sequences in, 3359 two cofactors and cytoplasmic chaper- Adl2-inducible fragile site, 6064 trkA cDNA onin, requirement for, 2478 U2 small nuclear ribonucleoprotein human a-Tubulin gene additional proteins, numerous, 307 neuroblastomas, expression in, 7447 X. laevis oocytes bipartite structure under splicing condi- Tropomyosin gene premature transcription termination, tions, 307 mouse 7925 U2 small nuclear RNA embryonic stem cells, expression in, a-Tubulin isogene products 3' end formation 3311 direction by critical internal structure embryos, expression in, 3311 A. nidulans distinct from processing site, 1119 Troponin I microtubule function, 4465 U2 small nuclear RNA gene D. melanogaster heldup3 mutant a-Tubulin locus, developmentally regulated R. hasegawae abnormal muscle development caused P. polycephalum mRNA-type intron, 5613 by splicing defect, 1433 two alleles replicate on different U5 small nuclear ribonucleoprotein particle Troponin I slow gene schedules, 449 protein rat Tumor necrosis factor S. cerevisiae cis-acting sequences, 7019 IKBa, phosphorylation and loss of, 3301 pre-mRNA splicing, involvement in, Trypanosoma brucei NF-KB activation, mechanism of, 3301 2959 calmodulin gene Tumor necrosis factor alpha U6 RNA gene promoter EF-hand 5 protein and ubiquitin ex- mitogenic response S. cerevisiae tension protein 52 genes, genomic c-Jun/AP-1, requirement for, 4284 architecture, 3015 and transcriptional linkage with, Tumor necrosis factor-responsive element U6 small nuclear RNA 207 human ACAGAGA and AGC sequences CR2 maxicircle transcripts osteocalcin gene, down-regulation of, mutation tolerance, 5377 editing, 6832 3714 mammalian EF-hand 5 protein gene TxREF protein 3' end modifications within the spli- calmodulin and ubiquitin extension human ceosome, 1641 protein 52 genes, genomic and cis element 6490 U6 small nuclear RNA transcriptional linkage with, 207 binding, gene glucose transporter genes Tyl human two distinct families, differential regu- S. cerevisiae distal control region, 4670 lation of, 1146 MCM1 binding to transcriptional con- U small nuclear RNA largest subunit RNA polymerase II trol element, 57 3'-end formation and transcription initia- genes, 3734 Ty2 tion ND9 protein S. cerevisiae plants, independent occurrences in, NADH dehydrogenase subunit, ho- interspersion of unusual GCN4 activa- 6403 mology to, 6832 tion site with complex transcrip- U small nuclear RNA/mRNA genes RNA-processing reactions tional repression site, 2091 N. plumbaginifolia temporal order, 720 repression of transcription by three protoplasts, 6403 trans splicing preceding polyadenyla- downstream sites, 2081 ubc-2 gene tion, 720 Tyrosine aminotransferase gene C. elegans small nuclear RNA distal enhancer ubiquitin-conjugating enzyme involved fibrillarin and pre-mRNAs, 144 liver-specific factors, binding to, 4494 in selective protein degradation, major nucleolar trimethylguanosine- ubiquitous factors, binding to, 4494 1371 VOL. 13, 1993 SUBJECT INDEX xliii

Ubiquitin extension protein 52 gene without DNA homology, 6957 U3 snRNP-requiring processing event, T. brucei human 5990 EF-hand 5 protein and calmodulin coding joint formation, 3900 TFIIIA genes, genomic and transcrip- signal joint formation, 3900 transcription-activating domain, 7496 tional linkage with, 207 P nucleotides zinc finger function in embryos, 4776 Ubiquitin overexpression fine-structure analysis, 1078 XMEK2 S. cerevisiae signal and coding joint resolution, 1363 MAP kinase activator, novel, 5738 clathrin deficiency, rescue of, 521 transcriptional enhancer elements, role XMEK3 Ubiquitin pathway of, 6223 MAP kinase activator, novel, 5738 human lymphocyte apoptosis, involve- transgenic mice XrpFI protein ment in, 4875 CpG methylation, influence of, 571 composition, 6479 Ultrabithorax homeodomain protein target spacing, influence of, 571 development, expression during, 6479 D. melanogaster VM-26 Xenopus laevis oocytes DNA binding, cooperative, 6941 topoisomerase II cleavage hot spots, in- 5S rRNA structural requirements urbsl gene duction of 60S ribosomal subunit assembly, 6819 U. maydis SV40 integration into cellular DNA, 7S RNP assembly, 6819 encoding of protein similar to 6190 nuclear transport, 6819 GATA-1, 7091 Vmw65 human c-myc gene elongation, 1296 siderophore biosynthesis, regulation herpes simplex virus MAP kinase stimulation of, 7091 acidic domain, transcriptional activa- Mos, 2546 Ustilago maydis tion by, 5233 maturation urbsl gene von Recklinghausen neurofibromatosis insulin stimulated, 6653 encoding of protein similar to (NFl) gene maturation, progesterone induced GATA-1, 7091 conserved alternative splice PI 3-kinase activity, importance for, siderophore biosynthesis, regulation neurofibromin isoforms with GTPase- 6661 of, 7091 activating protein activity, 487 Raf-1 protein kinase activity, 4197 UV hypermutability Mos xeroderma pigmentosum variant cells, Wnt-i MAP kinase stimulation, 2546 4276 neuroectodermal differentiation, expres- protein kinase C t UV response sion during NF-KB-like activity, block of activa- c-jun gene Wnt-l-inducing factor-1, regulation by, tion of, 1290 mediation, 5490 1590 a-tubulin gene transcription UVB light Wnt-l-inducing factor-1 premature termination, 7925 DNA breaks, induction of G/C box-binding transcription factor, Raf-1 protein kinase activity c-fos transcriptional induction, inter- novel mos activity, 4197 ference with, 6992 Wnt-i expression during neuroectoder- progesterone-induced maturation, 4197 UV-damaged DNA templates mal differentiation, regulation of, recombination, homologous and illegiti- replication and mutagenesis 1590 mate, 6897 human and monkey cell extracts, 533 Xeroderma pigmentosum Xenopus borealis variant cells Variant surface glycoprotein gene precursor rRNA 5' ETS psoralen adducts, defective replication T. brucei U3 snRNP-requiring processing event, of, 1002 putative expression site promoter, ret- 5990 UV hypermutability, 4276 roposon-like sequence upstream Xenopus laevis Xeroderma pigmentosum revertant cell line of, 7036 cyclin B2 amino terminus selective repair of the transcribed strand Vascular cell adhesion molecule 1 gene mitotic arrest, 1480 of an expressed gene, 970 expression developmentally regulated mRNA prod- UV resistance, increased, 970 NF-KB subunits, regulation by, 6283 uct XMEK2 Vascular smooth muscle cells S. cerevisiae SUP45, homology to, X. laevis rat 2815 MAP kinase activator, novel, 5738 Gax gene, down-regulation of, 3722 eggs XMEK3 Vertebrate mini-exon recombination, homologous and illegit- X. laevis recognition in vivo as an exon-intron- imate, 6897 MAP kinase activator, novel, 5738 exon unit, 2677 embryogenesis XRNl/KEMJ gene Vimentin promoter axis formation, modulation of, 7540 S. cerevisiae HKEJIRATi, homology to, human embryos 341 human T-cell leukemia virus type I single zinc finger function, 4776 XrpFI protein Tax protein, modulation by, 89 LFB1 protein X. laevis negative element, 89 expression, tissue specific and embry- composition, 6479 Vr2 gene onic, 6416 development, expression during, 6479 C parasitica liver transcription factor LFB1 (HNF1) targeted inactivation, 7782 developmental regulation and tissue YB-1 Viral 3' untranslated RNA pseudoknots distribution, 421 chicken phylogenetically conserved sequence MAP kinase liver, expression in, 4186 translation, regulation of, 5331 S. pombe Spkl, relationship to, 6427 YCKJ V(D)J recombinase MAP kinase activator family S. cerevisiae B-cell line, inducible, 6223 XMEK2, 5738 encodes protein kinase required for V(D)J recombination XMEK3, 5738 morphogenesis, 2870 Chinese hamster cell mutants c-, N-, and L-myc homologs YCK2 DNA double-strand break repair de- comparative analysis of expression S. cerevisiae fect, 3464 and oncogenic activities, 2456 encodes protein kinase required for coding junction formation precursor rRNA 5' ETS morphogenesis, 2870 xliv SUBJECT INDEX MOL. CELL. BIOL.

Yeast artificial chromosomes single-strand TG1_3 tails, formation of, myc family genes reconstructed 4057 differential expression levels, 2765 expression, 5469 YMEI gene oncogenic activity, 2765 genetic transfer, 5469 S. cerevisiae t2 globin promoter Yeast and mammalian cells inactivation, effect of, 5418 human functional conservation of helix-loop- YY1 protein globin regulatory element (HS-40), helix protein transcriptional activa- mouse activation by, 2298 tion motif, 792 IAP upstream element, interaction Zfp-42 gene Yeasts with, 6621 F9 teratocarcinoma cells, expression in linear mitochondrial DNA, 2309 pleiotropic effects, 6621 octamer motif, contribution of, 2919 linear mitochondrial DNAs c-myc promoter, activation of, 7487 Zinc finger genes closed-loop structure of termini, 2315 retinoic acid regulated linear-circular conversion mecha- Rex-1 (Zfp-42), 2919 nisms, 2315 ZEBRA activation domain S. cerevisiae c-Yes tyrosine kinase Epstein-Barr virus SNF1 protein kinase mutant, 3872 human mechanism of action, 7045 Zinc finger proteins elevated intracellular calcium levels, modular organization, 7045 rat inactivation by, 7507 Zebra fish HF-lb, 4432 YLpFAT10 linear plasmid max gene Zinc fingers S. cerevisiae constant expression level, 2765 TFIIIA origin activation, 4057 oncogenic activity, 2765 X laevis embryos, function in, 4776