2010 annual report an educational 501(c)3 nonprofi t organization Fiscal Year 2010 Meetings CONFERENCE SCIENTIFIC ORGANIZERS LOCATION DATES Telomere Biology and DNA Repair Roger R. Reddel, Michael B. Kastan, Titia de Lange Ashmore, Australia Oct 9 – 14, ‘09 Overcoming the Crisis of TB and AIDS Anne E. Goldfeld, Stefan H.E. Kaufmann Arusha, Tanzania Oct 20 – 25, ‘09 NF-kB in Inflammation and Disease Michelle A. Kelliher, Manolis Pasparakis, Jürg Tschopp Santa Fe, NM, USA Jan 5 – 10 Advances in Biopharmaceuticals John M. McPherson, Thomas F. Bumol Midway, UT, USA Jan 8 – 13 Structural Biology* Alasdair C. Steven, Pamela J. Bjorkman, Andrej Sali Breckenridge, CO, USA Jan 8 – 13 Structural Genomics: Expanding the Ian A. Wilson, Kurt Wüthrich, Soichi Wakatsuki, Breckenridge, CO, USA Jan 8 – 13 Horizons of Structural Biology* Christine A. Orengo Triglycerides and Triglyceride-Rich Robert H. Eckel, Ira J. Goldberg, Ruth McPherson Big Sky, MT, USA Jan 9 – 14 Particles in Health and Disease Alzheimer’s Disease Beyond Ab JoAnne McLaurin, Tony Wyss-Coray Copper Mountain, CO, USA Jan 10 – 15 Molecular Basis for Biological Membrane Tom A. Rapoport, Sandra L. Schmid Snowbird, UT, USA Jan 10 – 15 Organization and Dynamics HIV Biology and Pathogenesis Thomas J. Hope, Katherine A. Jones, Daniel C. Douek Santa Fe, NM, USA Jan 12 – 17 RNA Silencing: Mechanism, Biology and Application Phillip D. Zamore, Beverly L. Davidson Keystone, CO, USA Jan 14 – 19 Molecular Basis for Chromatin Jonathan Widom, Geeta Narlikar, Dinshaw J. Patel Taos, NM, USA Jan 17 – 22 Structure and Regulation Hypoxia: Molecular Mechanisms of Navdeep S. Chandel, Peter J. Ratcliffe, Volker H. Haase, Keystone, CO, USA Jan 19 – 24 Oxygen Sensing and Response Pathways Agnes Görlach Adipose Tissue Biology* Sheila Collins, Karsten Kristiansen, Silvia Corvera Keystone, CO, USA Jan 24 – 29 Neuronal Control of Appetite, Kevin L. Grove, Michael A. Cowley, Rexford S. Ahima Keystone, CO, USA Jan 24 – 29 Metabolism and Weight* New Insights into Healthspan and Diseases of Aging: Sean M. Oldham, David A. Sinclair, Jan Vijg, Heidi Scrable Tahoe City, CA, USA Jan 31– Feb 5 From Functional to Molecular Senescence Role of Inflammation in Oncogenesis* Nina Bhardwaj, Giorgio Trinchieri Keystone, CO, USA Feb 7 – 12 Molecular and Cellular Biology of George C. Prendergast, Dmitry I. Gabrilovich Keystone, CO, USA Feb 7 – 12 Immune Escape in Cancer* Advances in Molecular Mechanisms of Atherosclerosis* Russell A. DeBose-Boyd, Christopher K. Glass Banff, AB, Canada Feb 12 – 17 The Macrophage: Intersection of Peter J. Murray, Sabine Ehrt, Ajay Chawla Banff, AB, Canada Feb 12 – 17 Pathogenic and Protective Inflammation* Antibiotics and Resistance: Challenges and Solutions Gerry Wright, Deborah Hung, Stewart L. Fisher Santa Fe, NM, USA Feb 14 – 19 Stem Cell Differentiation and Dedifferentiation Shinya Yamanaka, Fiona M. Watt Keystone, CO, USA Feb 15 – 20 Cell Biology of Virus Entry, Replication Margaret Kielian, Peter Sarnow, Terence S. Dermody, Taos, NM, USA Feb 16 – 21 and Pathogenesis Paul D. Bieniasz RNA Silencing Mechanisms in Plants Marjori Ann Matzke, James C. Carrington Santa Fe, NM, USA Feb 21 – 26 Tolerance and Autoimmunity Betty Diamond, Diane J. Mathis Taos, NM, USA Feb 21 – 26 Cilia, Signaling and Human Disease Peter Jackson, Tim Stearns Monterey, CA, USA Feb 21 – 26 Lymphocyte Activation and Gene Expression Leslie J. Berg, Lawrence E. Samelson, Facundo D. Batista Breckenridge, CO, USA Feb 27 – Mar 4 Angiogenesis in Health and Disease* Michael Simons, William C. Sessa Keystone, CO, USA Feb 28 – Mar 5 Cardiovascular Development and Repair* Doris A. Taylor, Brian H. Annex Keystone, CO, USA Feb 28 – Mar 5 Biomolecular Interaction Networks: Function and Disease Anna Panchenko, Teresa Przytycka, Andrea Califano Québec City, QC, Canada Mar 7 – 12 Cell Death Pathways: Apoptosis, Autophagy and Necrosis* Guido Kroemer, Junying Yuan, Eileen P. White Vancouver, BC, Canada Mar 12 – 17 Metabolism and Cancer Progression* Eileen P. White, Craig B. Thompson, Chi Van Dang Vancouver, BC, Canada Mar 12 – 17 Receptors and Signaling in Plant Thomas Boller, Jen Sheen Tahoe City, CA, USA Mar 14 – 19 Development and Biotic Interactions HIV Vaccines* Wayne C. Koff, Lynn Morris, Marcus Altfeld Banff, AB, Canada Mar 21 – 26 Viral Immunity* Jonathan W. Yewdell, Akiko Iwasaki, Nicole L. La Gruta, Banff, AB, Canada Mar 21 – 26 Jack R. Bennink Nuclear Receptors: Signaling, W. Lee Kraus, Myles Brown, Karen Elizabeth Knudsen Keystone, CO, USA Mar 21 – 26 Gene Regulation and Cancer* Nuclear Receptors: Development, Carl S. Thummel, David D. Moore, Joyce J. Repa Keystone, CO, USA Mar 21 – 26 Physiology and Disease* New Paradigms in Cancer Therapeutics* Arul M. Chinnaiyan, William R. Sellers Victoria, BC, Canada Mar 23 – 28 Integration of Developmental Signaling Pathways* Jim Woodgett, Joseph Kelleher Victoria, BC, Canada Mar 23 – 28 G Protein-Coupled Receptors Brian K. Kobilka, Martin J. Lohse, Thue W. Schwartz Breckenridge, CO, USA Apr 7 – 12 Dynamics of Eukaryotic Transcription during Development Karen Adelman, Marc Timmers Big Sky, MT, USA Apr 7 – 12 Synapses: Formation, Function and Misfunction* Matthew B. Dalva, Peter Scheiffele, Yishi Jin Snowbird, UT, USA Apr 11 – 15 Toward Defining the Pathophysiology of Autistic Behavior* Pat Levitt, Joseph Piven Snowbird, UT, USA Apr 11 – 15 Malaria: New Approaches to Understanding Patrick E. Duffy, Jean Langhorne Copper Mountain, CO, USA Apr 11 – 16 Host-Parasite Interactions* Molecular Targets for Control of Vector-Borne Diseases: Kenneth D. Vernick, Elena A. Levashina, Gerry Killeen, Copper Mountain, CO, USA Apr 11 – 16 Bridging Lab and Field Research* Anthony A. James Islet Biology* Markus Stoffel, Doris A. Stoffers, Per-Olof Berggren Whistler, BC, Canada Apr 12 – 17 Diabetes* Juleen R. Zierath, Philippe Froguel, Nancy A. Thornberry, Whistler, BC, Canada Apr 12 – 17 Michael P. Czech Computer-Aided Drug Design* Michael K. Gilson, Catherine E. Peishoff, Jeff Blaney Whistler, BC, Canada Apr 20 – 25 New Directions in Small Molecule Drug Discovery* William J. Greenlee, George Hartman, Anna K. Mapp Whistler, BC, Canada Apr 20 – 25 Developmental Origins and Epigenesis in Human Judith Swain, Peter D. Gluckman, Michael Meaney, Singapore Apr 26 – 30 Health and Disease Anne Ferguson-Smith Bioactive Lipids: Biochemistry and Diseases Shuh Narumiya, Takao Shimizu, Garret A. FitzGerald Kyoto, Japan Jun 6 – 11 Innate Immunity: Mechanisms Linking with Luke A.J. O’Neill, Kate A. Fitzgerald, Averil I. Ma Dublin, Ireland Jun 7 – 12 Adaptive Immunity *Joint meetings from tHe cHaIr of tHe board highlight of 2010 for me was undoubtedly being appointed Chair of the Board of Directors of Keystone Symposia. I have been involved with Keystone ASymposia in various capacities for the past two decades. During that time, I have become even more convinced of the invaluable role this nonprofi t plays in elevating scientifi c discourse, enhancing careers – particularly those of newer investigators – and accelerating life science discovery. Keystone Symposia offers a unique environment for life science researchers to come together to discuss the latest developments. Has the new world of electronic communications made a physical meeting obsolete? The feedback suggests otherwise. For the 2010 season, 91% of attendees rated the meeting in which they participated to be “Excellent” or “Very Good,” while 97% of attendees said they would attend another Keystone Symposia conference. These ratings are as high if not higher than in previous years – and particularly impressive given that participants reported attending a smaller number of conferences overall during the year. Furthermore, many attendees reported that, as a result of the Keystone Symposia conference, they formed a collaboration or learned something, such as a new technique, that saved them time and money. Thanks to the generous support of corporate, foundation, government and individual donors, we are able not only to offer an increasing number of scholarships and travel Juleen R. Zierath, Ph.D. awards to deserving investigators, but also to keep the cost of attendance as affordable as possible for everyone. I believe another overlooked outcome of this support is that the meetings can focus strictly on the science and retain a collegial, non-commercial atmosphere unclouded by political and other agendas. We are extremely grateful for the support given to Keystone Symposia from all corners of the scientifi c community. The combination of registration fee revenue and this external support has enabled Keystone Symposia to maintain a solid fi nancial position in challenging economic times. I consider it truly an honor to be heading the governing board of Keystone Symposia. The organization is already fortunate to have very capable leadership in the form of CEO James Aiken, CSO Andrew Robertson and CFO Pamela Daugherty, plus others on the staff, Board of Directors and Scientifi c Advisory Board. As we approach Keystone Symposia’s 40th anniversary in 2012, my goal is to steer the organization in an even more international direction, in terms of both the locations where meetings are held and the composition of participants. Raising the profi le of the organization further on both a national and international scale will help to ensure continued, robust external support. In the coming years, I look forward to meeting many of you, the participants, generous donors and others who make Keystone Symposia’s mission possible. On behalf of the Board of Directors, Juleen