DOCSLIB.ORG

Interaction Entre Le Stress Du Réticulum Endoplasmique Et La Voie Mtor

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Interaction Entre Le Stress Du Réticulum Endoplasmique Et La Voie Mtor Interaction entre le stress du réticulum endoplasmique et la voie mTOR dans les néoplasmes neuroendocrines gastro-entéro-pancréatiques : vers une nouvelle option thérapeutique ? Patricia Freis To cite this version: Patricia Freis. Interaction entre le stress du réticulum endoplasmique et la voie mTOR dans les néoplasmes neuroendocrines gastro-entéro-pancréatiques : vers une nouvelle option thérapeutique ?. Cancer. Université de Lyon, 2017. Français. NNT : 2017LYSE1079. tel-01538466 HAL Id: tel-01538466 https://tel.archives-ouvertes.fr/tel-01538466 Submitted on 13 Jun 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N° G¶RUGUH1172017LYSE1079 7+(6(GH'2&725$7'(/¶81,9(56,7('(/<21 opérée au sein de O¶8QLYHUVLWp&ODXGH%HUQDUG/\RQ Ecole Doctorale ED 340 Biologie Moléculaire Intégrative et Cellulaire Spécialité de doctorat : Biologie Discipline : Cancérologie Soutenue publiquement le 19/05/2017, par : Patricia Freis Interaction entre le stress du réticulum endoplasmique et la voie mTOR dans les néoplasmes neuroendocrines gastro-entéro-pancréatiques : vers une nouvelle option thérapeutique ? Devant le jury composé de : Buscail Louis, PU-PH, Hôpital Rangueil/CRCT Rapporteur Foufelle Fabienne, Dr, Centre de recherches des Cordeliers Rapportrice Mollereau Bertrand, Dr, ENS de Lyon Examinateur Scoazec Jean-Yves, PU-PH, IGR Examinateur Walter Thomas, PU-PH, HCL/UCBL1 Examinateur Ferraro-Peyret Carole, MCU-PH, HCL/UCBL1 Directrice de thèse UNIVERSITE CLAUDE BERNARD - LYON 1 3UpVLGHQWGHO¶8QLYHUVLWp M. le Professeur Frédéric FLEURY Président du Conseil Académique M. le Professeur Hamda BEN HADID Vice-SUpVLGHQWGX&RQVHLOG¶$GPLQLVWUDWLRQ M. le Professeur Didier REVEL Vice-président du Conseil Formation et Vie Universitaire M. le Professeur Philippe CHEVALIER Vice-président de la Commission Recherche M. Fabrice VALLÉE Directrice Générale des Services Mme Dominique MARCHAND COMPOSANTES SANTE Faculté de Médecine Lyon Est ± Claude Bernard Directeur : M. le Professeur G.RODE Faculté de Médecine et de Maïeutique Lyon Sud ± Charles Directeur : Mme la Professeure C. BURILLON Mérieux )DFXOWpG¶2GRQWRORJLH Directeur : M. le Professeur D. BOURGEOIS Institut des Sciences Pharmaceutiques et Biologiques Directeur : Mme la Professeure C. VINCIGUERRA Institut des Sciences et Techniques de la Réadaptation Directeur : M. X. PERROT Département de formation et Centre de Recherche en Biologie Directeur : Mme la Professeure A-M. SCHOTT Humaine COMPOSANTES ET DEPARTEMENTS DE SCIENCES ET TECHNOLOGIE Faculté des Sciences et Technologies Directeur : M. F. DE MARCHI Département Biologie Directeur : M. le Professeur F. THEVENARD Département Chimie Biochimie Directeur : Mme C. FELIX Département GEP Directeur : M. Hassan HAMMOURI Département Informatique Directeur : M. le Professeur S. AKKOUCHE Département Mathématiques Directeur : M. le Professeur G. TOMANOV Département Mécanique Directeur : M. le Professeur H. BEN HADID Département Physique Directeur : M. le Professeur J-C PLENET UFR Sciences et Techniques des Activités Physiques et Sportives Directeur : M. Y.VANPOULLE 2EVHUYDWRLUHGHV6FLHQFHVGHO¶8QLYHUVGH/\RQ Directeur : M. B. GUIDERDONI Polytech Lyon Directeur : M. le Professeur E.PERRIN Ecole Supérieure de Chimie Physique Electronique Directeur : M. G. PIGNAULT Institut Universitaire de Technologie de Lyon 1 Directeur : M. le Professeur C. VITON (FROH6XSpULHXUHGX3URIHVVRUDWHWGHO¶(GXFDWLRQ Directeur : M. le Professeur A. MOUGNIOTTE Institut de Science Financière et d'Assurances Directeur : M. N. LEBOISNE 1 2 REMERCIEMENTS -H VRXKDLWH WRXW G¶DERUG UHPHUFLHU OH 'RFWHXU )DELHQQH )RXIHOOH HW OH 3URIHVVHXU /RXLV Buscail pour avoir accepté d¶H[DPLQHUFHWUDYDLOHQWDQWTXHUDSSRUWHXUVGHPRQMXU\ de thèse et SRXUO¶DWWHQWLRQTX¶LOVSRUWHURQWjFHWUDYDLO Je remercie le Docteur Bertrand Mollereau, le Professeur Jean-Yves Scoazec et le Professeur 7KRPDV:DOWHUSRXUO¶KRQQHXUTX¶LOVP¶RQWIDLWHQDFFHSWDQWG¶rWUHPHPEUHVGHFHMXU\ Je remercie le Docteur Carole Ferraro-Peyret, ma directrice de thèse, pour la confiance TX¶HOOHP¶DWpPRLJQpHHQDFFHSWDQWGHGLULJHUPHVWUDYDX[LO\DPDLQWHQDQWDQVHWGHPLTXDQG M¶DL IDLW OH FKRL[ GH VXLYUH OD ILOLqUH ,QQRYDWLRQ 3KDUPDFHXWLTXH HW 5HFKHUFKH GH O¶LQWHUnat en Pharmacie à Lyon. Merci pour votre soutien et votre engagement dans la construction de mon parcours professionnel scientifique, du Master2 à la thèse de Doctorat. $-RsOOHWRLTXLpWDLVUpWLFHQWHjO¶DUULYpHG¶pWXGLDQWVSRXUWUDYDLOOHUDYHFWRLM¶HVSqUHW¶DYRLU IDLW FKDQJHU G¶DYLV 0HUFL GH P¶DYRLU WUDQVPLV WHV FRQQDLVVDQFHV WHFKQLTXHV j PRQ DUULYpH DX ODERUDWRLUHSRXUWDFRQVWDQWHERQQHKXPHXUHWO¶DPELDQFHMR\HXVHTXHWXPHWVSDUWRXWRWXSDVVHV Enfin merci pour ton aide et ton travail durant ces 4 années qui ont finalement payé par la publication de nos résultats. -HUHPHUFLHOH'RFWHXU6HUJH0DQLpSRXUP¶DYRLUDSSRUWpVRQDLGHHWVRQDQDO\VHSHUWLQHQWH de mes résultats, lors des réunions du mercredi matin. Merci pour la relecture de la partie Stress du réticulum de mon manuscrit. -HUHPHUFLHOHVPHPEUHVGHO¶pTXLSH6HUJH0DQLpjVDYRLU$XGUH\&DUPHQ&pGULF&&pGULF '6RILDQHHW9LUJLQLHSRXUG¶XQHSDUWOHXUDFFXHLOjPRQDUULYpHGDQVO¶pTXLSHHWG¶DXWUHSDUWOHXU aide technique, scientifique, mais aussi morale dans les moments plus compliqués des années de WKqVH0HUFLSRXUYRWUHVRXWLHQHWSRXUOHVERQVPRPHQWVTXHO¶RQDSDVVpHQVHPEOH ! -¶DLpJDOHPHQWXQHSHQVpHSRXUOHVDQFLHQVGH/DHQQHFQRWDPPHQW-XOLHQHW3DWULFNTXHMH remHUFLHFKDOHXUHXVHPHQWSRXUWRXWFHTX¶LOVRQWVXP¶DSSRUWHUVFLHQWLILTXHPHQWFDURXLRQSRXYDLW discuter sérieusement, mais aussi pour tous ces moments de détente partagés avec les stagiaires de M2 (Just Dance !). 3 -HUHPHUFLH$OMDDYHFTXLM¶DLEHDXFRup partagé lors de notre année de M2. Je te souhaite beaucoup de courage pour terminer toi aussi ta thèse, et bonne chance pour la suite, en France ou ailleurs ? 0HUFL j WRXWHV OHV SHUVRQQHV TXH M¶DL SX F{WR\HU GDQV O¶pTXLSH GX 3URIHVVHXU -HDQ-Yves Scoazec HWGX'RFWHXU=KDQJjODIDFXOWpGH/DHQQHFHWjFHOOHVTXHM¶DLUHQFRQWUpHVGDQVO¶pTXLSH du Docteur Touffic Renno, suite à la restructuration des équipes du CRCL en 2015. Je vais me répéter avec les remerciements de la thèse de Pharmacie, mais encore une fois, PHUFL0DPDQHW3DSDSRXUYRWUHVRXWLHQHWYRWUHDLGHGXUDQWWRXWHVFHVDQQpHVG¶pWXGHV oDYDIDLUH DQVFHWWHDQQpHTXHM¶DLSDVVpOHEDF !), et pour tous vos conseils. Merci aussi aux Lorrains, Sophie, Pierre, Kévin, Guillaume, pour votre présence tout simplement tout au long de ces annéesHWSRXUWRXWFHTX¶RQDSDUWDJp DXFROOqJHDXO\FpHRXjOD IDF HWFHTX¶RQSDUWDJHUDHQFRUHMHO¶HVSqUH ! LHSHWLWFKDW/pRP¶DVRXWHQXGXUDQWOHVòPRLVG¶pFULWXUHGHPDWKqVHHQGRUPDQWVXUOH bureau (eWSDUIRLVVXUOHFODYLHU &¶HVW une boule de poils anti-stress plutôt efficace. (WSRXUWHUPLQHUPHUFL/DXUHQWSRXUDYRLUVXSSRUWpO¶pSUHXYHGHODnde WKqVH F¶HVWVU F¶HVWODGHUQLqUH 0HUFLSRXUWHVFRQVHLOVHWWRQVRXWLHQQRWDPPHQWGXUDnt cette dernière année plus compliquée que prévue. Merci pour tout. Et maintenant, chers lecteurs, certains G¶HQWUH YRXV V¶DUUrWHURQW LFL, G¶DXWUHV DXURQW OH courage de continuer, alors je vous en remercie et vous souhaite une bonne lecture. 4 TABLE DES MATIERES Remerciements .................................................................................................................................... 3 Liste des abréviations ........................................................................................................................... 9 Liste des illustrations et tableaux ...................................................................................................... 13 Introduction ....................................................................................................................................... 15 Données bibliographiques ................................................................................................................. 17 Première partie ʹ Les néoplasmes neuroendocrines gastro-entéro-pancréatiques (NNE GEP) ... 19 1. Les cellules neuroendocrines .............................................................................................. 19 1.1. Définition ...................................................................................................................... 19 1.2. Fonctions ...................................................................................................................... 20 1.3. Origine embryologique ................................................................................................ 22 2. Les néoplasmes neuroendocrines gastro-entéro-pancréatiques ........................................... 24 2.1. Epidémiologie ................................................................................................................... 24 2.2. Caractéristiques ............................................................................................................... 24 2.3. Classification .................................................................................................................... 25 2.4. Syndrome de prédisposition génétique ........................................................................... 28 2.4.1. Les néoplasies endocriniennes multiples .................................................................
Load more

Recommended publications
  • Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
    SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland.
    [Show full text]
  • The Roles of Atf3 in Stress-Regulated Signal Transduction
    THE ROLES OF ATF3 IN STRESS-REGULATED SIGNAL TRANSDUCTION AND CELL DEATH IN PANCREATIC BETA-CELLS DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Matthew G. Hartman, B.S. * * * * * The Ohio State University 2005 Dissertation Committee: Approved by Dr. Tsonwin Hai, Advisor Dr. Gary Kociba Advisor Dr. James DeWille Molecular, Cellular and Developmental Biology Program Dr. John Oberdick ABSTRACT Currently there are 20 million people diagnosed with diabetes in the United States and the incidence is expected to increase by 42% over the next twenty years. Type 1, or insulin-dependent diabetes, is an autoimmune disorder characterized by infiltration of activated T-lymphocytes into the pancreas. Auto- reactive immune cells initiate β-cell destruction by several mechanisms including secretion of soluble factors (cytokines), direct cell-cell contact, and activation of osmotic lysis signals. Type 2, or insulin-independent diabetes, is characterized by insulin resistance in the peripheral tissues such as the liver, fat, and skeletal muscle. Phosphorylation of key substrates involved in the insulin signal transduction pathway by stress-activated protein kinases contributes to the insulin resistance and prevents the uptake of glucose from the blood. Recent reports suggest that type 2 diabetes is a slower progressing form of type 1 and that β-cell apoptosis contributes to the pathogenesis of both forms. Activating Transcription Factor 3 (ATF3) is a member of the ATF/CREB family of transcription factors which regulate gene expression through their ability to bind a common DNA sequence motif (TGACGTCA).
    [Show full text]
  • Pnas11052ackreviewers 5098..5136
    Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H.
    [Show full text]
  • R. Luke Wiseman, Ph.D. Associate Professor Department of Molecular
    Wiseman CV R. Luke Wiseman, Ph.D. Associate Professor Department of Molecular Medicine The Scripps Research Institute MEM 220 La Jolla, CA 92037 Phone: (858) 784-8820 Email: [email protected] Education/Training 9/2005 – 8/2009 Skirball Institute at NYU Medical School New York, NY NIH Postdoctoral Research Fellow 7/2001 – 8/2005 The Scripps Research Institute La Jolla, CA Ph.D. Chemistry 9/1997 – 5/2001 The University of Virginia Charlottesville, VA B.Sc. Chemistry Positions/Employment 12/2016 – present The Scripps Research Institute La Jolla, CA Associate Professor (tenured) 8/2009 – 12/2016 The Scripps Research Institute La Jolla, CA Assistant Professor 9/2005 – 8/2009 Skirball Institute at NYU Medical School New York, NY NIH Postdoctoral Research Fellow; Advisor – David Ron 7/2001 – 8/2005 The Scripps Research Institute La Jolla, CA Graduate Research Associate; Advisor – Jeffery W. Kelly 8/2000 – 5/2001 University of Virginia Charlottesville, VA Undergraduate Research Associate; Advisor – Milton Brown 9/1999 – 7/2000 University of Virginia Charlottesville, VA Undergraduate Research Associate; Advisor – Felicia Etzkorn 5/1999 – 8/1999 Cornell University (REU Program) Ithaca, NY Undergraduate Research Associate; Advisor – David Zax Teaching Experience Wiseman CV 2017-present The Scripps Research Institute La Jolla, CA Lecturer – Chemical Biology I 2014-present The Scripps Research Institute La Jolla, CA Course Organizer – Cell Biology 2012-present The Scripps Research Institute La Jolla, CA Lecturer – Structural Biology 2011 – present
    [Show full text]
  • BIOLOGY 639 SCIENCE ONLINE the Unexpected Brains Behind Blood Vessel Growth 641 THIS WEEK in SCIENCE 668 U.K
    4 February 2005 Vol. 307 No. 5710 Pages 629–796 $10 07%.'+%#%+& 2416'+0(70%6+10 37#06+6#6+8' 51(69#4' #/2.+(+%#6+10 %'..$+1.1); %.10+0) /+%41#44#;5 #0#.;5+5 #0#.;5+5 2%4 51.76+105 Finish first with a superior species. 50% faster real-time results with FullVelocity™ QPCR Kits! Our FullVelocity™ master mixes use a novel enzyme species to deliver Superior Performance vs. Taq -Based Reagents FullVelocity™ Taq -Based real-time results faster than conventional reagents. With a simple change Reagent Kits Reagent Kits Enzyme species High-speed Thermus to the thermal profile on your existing real-time PCR system, the archaeal Fast time to results FullVelocity technology provides you high-speed amplification without Enzyme thermostability dUTP incorporation requiring any special equipment or re-optimization. SYBR® Green tolerance Price per reaction $$$ • Fast, economical • Efficient, specific and • Probe and SYBR® results sensitive Green chemistries Need More Information? Give Us A Call: Ask Us About These Great Products: Stratagene USA and Canada Stratagene Europe FullVelocity™ QPCR Master Mix* 600561 Order: (800) 424-5444 x3 Order: 00800-7000-7000 FullVelocity™ QRT-PCR Master Mix* 600562 Technical Services: (800) 894-1304 Technical Services: 00800-7400-7400 FullVelocity™ SYBR® Green QPCR Master Mix 600581 FullVelocity™ SYBR® Green QRT-PCR Master Mix 600582 Stratagene Japan K.K. *U.S. Patent Nos. 6,528,254, 6,548,250, and patents pending. Order: 03-5159-2060 Purchase of these products is accompanied by a license to use them in the Polymerase Chain Reaction (PCR) Technical Services: 03-5159-2070 process in conjunction with a thermal cycler whose use in the automated performance of the PCR process is YYYUVTCVCIGPGEQO covered by the up-front license fee, either by payment to Applied Biosystems or as purchased, i.e., an authorized thermal cycler.
    [Show full text]
  • Astbury Centre for Structural Molecular Biology Annual Report
    The Astbury Centre for Structural Molecular Biology ANNUAL REPORT 2016 Front cover illustration Folding of the protein Im7 in the presence or absence of the small, periplasmic ATP-independent chaperone Spy from E. coli. Im7 is shown as a multi-coloured protein that is helical in both the folding intermediate (I) and in the native folded state (N) and lacks any persistent secondary structure in the unfolded state (U). Spy is shown as a blue cradle-shaped homodimer. The kinetic mechanism of Im7 folding in the presence of Spy was investigated as part of a collaboration between the Radford (Leeds) and Bardwell (Michigan) groups and published in Nat. Struct. Mol. Biol. in 2016. More details can be found on p58 of this report. Acknowledgement The Astbury Centre for Structural Molecular Biology thanks its many sponsors for support of the work and its members for writing these reports. The report is edited by David Brockwell. This report is also available electronically at www.astbury.leeds.ac.uk I prefix Mission Statement TheAstbury Centre forStructural Molecular Biologywillpromoteinterdisciplinaryresearchofthe higheststandardonthe structure andfunctionofbiological molecules, biomolecularassemblies andcomplexes usingphysico-chemical,molecularbiological andcomputational approaches. www.astbury.leeds.ac.uk II prefix Introduction Welcometothe Annual Report of theAstbury Centre for2016. We have hadanother very busy andsuccessful year andthisletterhighlights afew of ourmanysuccesses.The Astbury Report is ashining exampleofthe buoyancy of ourscience, thestrengthofour community andour collaborations that go hand in hand with thecontributionsour members make to others through engagementinpublic-facingevents. Iwould liketothank every member of theCentre fortheir hard work over theyear: ourSupport staff, Technicians, Facility Managers, Students, Post-docs, Fellowsand Academic staff.
    [Show full text]
  • The Eukaryotic Translation Initiation Factor 2, a Hero Turned Villain in Β Cells
    The eukaryotic translation initiation factor 2, a hero turned villain in β cells By Baroj Abdulkarim Université libre de Bruxelles Faculty of Medicine ULB Center for Diabetes Research Academic year 2016-2017 Jury Members: Dr. Ingrid Langer (President) Dr. Miriam Cnop (Promoter and secretary) Dr. Mariana Igoillo Esteve (Co-Promoter) Dr. Daniel Christophe Dr. Christophe Erneux Dr. Claudine Heinrichs Dr. Amar Abderrahmani Dr. Patrick Gilon Dedicated to my daughter Elîn 2 Contents Papers constituting this thesis .................................................................................... 4 Abbreviations .............................................................................................................. 5 Abstract ...................................................................................................................... 8 Résumé ...................................................................................................................... 9 Introduction ............................................................................................................... 10 Diabetes mellitus ................................................................................................... 10 How β cells work ................................................................................................ 11 Type 2 and monogenic diabetes ........................................................................ 12 Free fatty acids and diabetes ...............................................................................
    [Show full text]
  • 2013 Fellowship Election Results
    6/14/13 Academy of Medical Sciences - May 2013 - Newsletter 2013 Fellowship election results 44 of the UK’s leading medical researchers have been recognised for excellence in medical science with their election to the Academy Fellowship. These distinguished scientists bring the total number of Academy Fellows to 1095. We offer the new Fellows our warmest congratulations on their election and welcome them to the Academy. The Fellows will be formally admitted during a ceremony on Wednesday 26 June. All Fellows are warmly invited to attend the day’s events. As well as the election of new Fellows, the day includes presentations from four new Fellows and a keynote lecture from Professor Peter Ratcliffe FRS FMedSci. This year Admission Day will be held at The Royal Society and the day will conclude with the annual Fellows summer soirée. Fellows elected in 2013 Dr Facundo Batista, Lead Researcher, Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK Professor David Beech,Professor of Cardiovascular Science, University of Leeds Professor Gurdyal Besra, Bardrick Professor of Microbial Physiology and Chemistry, University of Birmingham Professor Barbara Casadei, British Heart Foundation Professor of Cardiovascular Medicine and Hon. Consultant Cardiologist, University of Oxford Professor Jane Clarke, Wellcome Trust Senior Research Fellow in Basic Biomedical Science and Professor of Molecular Biophysics, University of Cambridge For further information contact Professor Garth Cooper, Professor in Discovery and Experimental
    [Show full text]
  • Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice Against Experimental Autoimmune Encephalomyelitis
    5980 • The Journal of Neuroscience, April 3, 2013 • 33(14):5980–5991 Neurobiology of Disease Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis Wensheng Lin,1,2 Yifeng Lin,1 Jin Li,1 Ali G. Fenstermaker,3 Sharon W. Way,3 Benjamin Clayton,3 Stephanie Jamison,1 Heather P. Harding,4 David Ron,4 and Brian Popko3 1Department of Cell Biology & Neuroscience, University of South Alabama College of Medicine, Mobile, Alabama 36688, 2Department of Comparative Medicine, University of South Alabama College of Medicine, Mobile, Alabama 36688, 3Department of Neurology, University of Chicago, Chicago, Illinois 60637, and 4University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge CB20QQ, United Kingdom There is compelling evidence that oligodendrocyte apoptosis, in response to CNS inflammation, contributes significantly to the develop- ment of the demyelinating disorder multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). There- fore, approaches designed to protect oligodendrocytes would likely have therapeutic value. Activation of pancreatic endoplasmic reticulum kinase (PERK) signaling in response to endoplasmic reticulum (ER) stress increases cell survival under various cytotoxic conditions. Moreover, there is evidence that PERK signaling is activated in oligodendrocytes within demyelinating lesions in multiple sclerosis and EAE. Our previous study demonstrated that CNS delivery of the inflammatory cytokine interferon-␥ before EAE onset protected mice against EAE, and this protection was dependent on PERK signaling. In our current study, we sought to elucidate the role ofPERKsignalinginoligodendrocytesduringEAE.WegeneratedtransgenicmicethatallowfortemporallycontrolledactivationofPERK signaling, in the absence of ER stress, specifically in oligodendrocytes. We demonstrated that persistent activation of PERK signaling was not deleterious to oligodendrocyte viability or the myelin of adult animals.
    [Show full text]
  • Doug Cavener – Perks and the Unfolded Protein Response
    Protein Misfolding and Misprocessing in Disease January 27-28, 2009 Lister Hill Auditorium, NIH Campus, Bethesda, MD 1. Meeting Summary Judith Fradkin (Director, Division of Diabetes, Endocrinology and Metabolic Diseases NIDDK) introduced the meeting, noting that the primary objective was to stimulate research that will translate basic cell biology, biochemistry and biophysics findings about protein structure and assembly into potential therapies for monogenic and other misfolding and misprocessing disorders. The meeting was well-attended with 208 participants. The audience included clinicians, clinical researchers and basic scientists at all career levels from academic institutions, the NIH, and the private sector. On the first morning, speakers focused on the basic biology of protein folding and processing, beginning with two keynote presentations; one by Linda Hendershot (Saint Judes Children’s Research Hospital) focusing on the basic cellular machinery involved in protein folding and quality control in the endoplasmic reticulum (ER) and another by David Ron (NYU School of Medicine) focusing on potential therapeutic opportunities related to the unfolded protein response. The afternoon session entitled “ER Stress and Mis-folding in Disease, Novel Outcomes” began with the presentation of an exciting new concept called proteostatis by Jeff Kelly (Scripps). He gave several examples of how in amyloidoses there are often multiple pathways, some of which or now well described, that can be modulated together each in small ways, resulting in improved outcomes in disease models. Subsequent speakers continued discussing the insights that have been gained about the biology of specific conformational diseases in model organisms, such as alpha1 anti-trypsin deficiency, Wolfram syndrome, cystic fibrosis and congenital hyperinsulinism.
    [Show full text]
  • Trustees' Report and Financial Statements 2014-15
    TRUSTEES’ REPORT AND FINANCIAL STATEMENTS 1 Trustees’ report and financial statements For the year ended 31 March 2015 2 TRUSTEES’ REPORT AND FINANCIAL STATEMENTS Trustees Executive Director The Trustees of the Society are the Dr Julie Maxton members of its Council, who are elected Statutory Auditor by and from the Fellowship. Council is Deloitte LLP chaired by the President of the Society. Abbots House During 2014/15, the members of Council Abbey Street were as follows: Reading President RG1 3BD Sir Paul Nurse Bankers Treasurer The Royal Bank of Scotland Professor Anthony Cheetham 1 Princess Street London Physical Secretary EC2R 8BP Sir John Pethica* Professor Alexander Halliday** Investment Managers Rathbone Brothers PLC Biological Secretary 1 Curzon Street Sir John Skehel London Foreign Secretary W1J 5FB Professor Martyn Poliakoff CBE Internal Auditors Members of Council PricewaterhouseCoopers LLP Sir John Beddington CMG Cornwall Court Professor Geoffrey Boulton* 19 Cornwall Street Professor Andrea Brand Birmingham Professor Michael Cates B3 2DT Dame Athene Donald DBE Professor Carlos Frenk Professor Uta Frith DBE** Professor Joanna Haigh** Registered Charity Number 207043 Dame Wendy Hall DBE Registered address Dr Hermann Hauser** 6 – 9 Carlton House Terrace Dame Frances Kirwan DBE London SW1Y 5AG Professor Ottoline Leyser CBE Professor Angela McLean royalsociety.org Professor Georgina Mace CBE Professor Roger Owen Professor Timothy Pedley* Dame Nancy Rothwell DBE Professor Stephen Sparks CBE** Professor Ian Stewart** Dame Janet Thornton DBE** Professor John Wood* * Until 1 December 2014 ** From 1 December 2014 TRUSTEES’ REPORT AND FINANCIAL STATEMENTS 3 Contents President’s foreword ................................................ 4 Executive Director’s report ............................................ 5 Trustees’ report ................................................... 6 Promoting science and its benefits ...................................
    [Show full text]
  • Membership of Sectional Committees 2015
    Membership of Sectional Committees 2015 The main responsibility of the Sectional Committees is to select a short list of candidates for consideration by Council for election to the Fellowship. The Committees meet twice a year, in January and March. SECTIONAL COMMITTEE 1 [1963] SECTIONAL COMMITTEE 3 [1963] Mathematics Chemistry Chair: Professor Keith Ball Chair: Professor Anthony Stace Members: Members: Professor Philip Candelas Professor Varinder Aggarwal Professor Ben Green Professor Harry Anderson Professor John Hinch Professor Steven Armes Professor Christopher Hull Professor Paul Attfield Professor Richard Kerswell Professor Shankar Balasubramanian Professor Chandrashekhar Khare Professor Philip Bartlett Professor Steffen Lauritzen Professor Geoffrey Cloke Professor David MacKay Professor Peter Edwards Professor Robert MacKay Professor Malcolm Levitt Professor James McKernan Professor John Maier Professor Michael Paterson Professor Stephen Mann Professor Mary Rees Professor David Manolopoulos Professor John Toland Professor Paul O’Brien Professor Srinivasa Varadhan Professor David Parker Professor Alex Wilkie Professor Stephen Withers SECTIONAL COMMITTEE 2 [1963] SECTIONAL COMMITTEE 4 [1990] Astronomy and physics Engineering Chair: Professor Simon White Chair: Professor Hywel Thomas Members: Members: Professor Girish Agarwal Professor Ross Anderson Professor Michael Coey Professor Alan Bundy Professor Jack Connor Professor Michael Burdekin Professor Laurence Eaves Professor Russell Cowburn Professor Nigel Glover Professor John Crowcroft
    [Show full text]