Biological Diversity and Sustainable Resources Use
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Scorpion Venom: New Promise in the Treatment of Cancer
Acta Biológica Colombiana ISSN: 0120-548X ISSN: 1900-1649 Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología SCORPION VENOM: NEW PROMISE IN THE TREATMENT OF CANCER GÓMEZ RAVE, Lyz Jenny; MUÑOZ BRAVO, Adriana Ximena; SIERRA CASTRILLO, Jhoalmis; ROMÁN MARÍN, Laura Melisa; CORREDOR PEREIRA, Carlos SCORPION VENOM: NEW PROMISE IN THE TREATMENT OF CANCER Acta Biológica Colombiana, vol. 24, no. 2, 2019 Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología Available in: http://www.redalyc.org/articulo.oa?id=319060771002 DOI: 10.15446/abc.v24n2.71512 PDF generated from XML JATS4R by Redalyc Project academic non-profit, developed under the open access initiative Revisión SCORPION VENOM: NEW PROMISE IN THE TREATMENT OF CANCER Veneno de escorpión: Una nueva promesa en el tratamiento del cáncer Lyz Jenny GÓMEZ RAVE 12* Institución Universitaria Colegio Mayor de Antioquia, Colombia Adriana Ximena MUÑOZ BRAVO 12 Institución Universitaria Colegio Mayor de Antioquia, Colombia Jhoalmis SIERRA CASTRILLO 3 [email protected] Universidad de Santander, Colombia Laura Melisa ROMÁN MARÍN 1 Institución Universitaria Colegio Mayor de Antioquia, Colombia Carlos CORREDOR PEREIRA 4 Acta Biológica Colombiana, vol. 24, no. 2, 2019 Universidad Simón Bolívar, Colombia Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología Received: 04 April 2018 ABSTRACT: Cancer is a public health problem due to its high worldwide Revised document received: 29 December 2018 morbimortality. Current treatment protocols do not guarantee complete remission, Accepted: 07 February 2019 which has prompted to search for new and more effective antitumoral compounds. Several substances exhibiting cytostatic and cytotoxic effects over cancer cells might DOI: 10.15446/abc.v24n2.71512 contribute to the treatment of this pathology. -
Universidad Técnica Particular De Loja Àrea
UNIVERSIDAD TÉCNICA PARTICULAR DE LOJA La Universidad católica de Loja ÀREA BIOLÓGICA TITULO DE BIOQUÍMICA Y FARMACIA Obtención de extractos, aislamiento y caracterización de metabolitos secundarios de la especie Erythrina smithiana. TRABAJO DE TITULACIÓN AUTOR: Aguilar Jaramillo, Hermes Leonardo DIRECTOR: Romero Benavides, Juan Carlos, Ing. LOJA – ECUADOR 2015 Esta versión digital, ha sido acreditada bajo la licencia Creative Commons 4.0, CC BY-NY- SA: Reconocimiento-No comercial-Compartir igual; la cual permite copiar, distribuir y comunicar públicamente la obra, mientras se reconozca la autoría original, no se utilice con fines comerciales y se permiten obras derivadas, siempre que mantenga la misma licencia al ser divulgada. http://creativecommons.org/licenses/by-nc-sa/4.0/deed.es Septiembre, 2015 APROBACIÓN DEL DIRECTOR DEL TRABAJO DE TITULACIÓN Ingeniero. Juan Carlos Romero Benavides. DOCENTE DE LA TITULACIÓN De mi consideración: El presente trabajo de titulación: “Obtención de extractos, aislamiento y caracterización de metabolitos secundarios de la especie Erythrina smithiana con actividad antiparasitaria”, realizado por Hermes Leonardo Aguilar Jaramillo, ha sido orientado y revisado durante su ejecución, por cuanto se aprueba la presentación del mismo. Loja, septiembre de 2015 f)____________________________ Ing. Romero Benavides Juan Carlos C.I. 1103018477 ii DECLARACIÓN DE AUTORÍA Y CESIÓN DE DERECHOS. Yo, Hermes Leonardo Aguilar Jaramillo, declaro ser autor del presente trabajo de titulación: “Obtención de extractos, aislamiento y caracterización de metabolitos secundarios de la especie Erythrina smithiana con actividad antiparasitaria”, de la titulación de Bioquímica y Farmacia, siendo el Ing. Juan Carlos Romero Benavides, director del presente trabajo; y eximo expresamente a la Universidad Técnica Particular de Loja y a sus representantes legales de posibles reclamos o acciones legales. -
Observations on the Gorgonian Coral Primnoa Pacifica at the Knight Inlet Sill, British Columbia 2008 to 2013
Observations on the Gorgonian Coral Primnoa pacifica at the Knight Inlet sill, British Columbia 2008 to 2013 By Neil McDaniel1 and Doug Swanston2 May 1, 2013 Background The fjords of British Columbia are glacially-carved troughs that snake their way through the coastal mountains, attaining depths as great as 760 m. Knight Inlet is especially long, extending 120 km northeast from an entrance located 240 km northwest of Vancouver, near the north end of Vancouver Island. Despite a maximum depth of 540 m it has a relatively shallow sill lying between Hoeya Head and Prominent Point with a maximum depth of only 65 m. Due to the shallow nature of the sill, tidal currents frequently exceed 0.5 m/second. ____________________ 1 [email protected] 2 [email protected] 1 The site has been of particular interest to oceanographers as the classical shape of this sill results in the presence of internal gravity waves and other interesting hydraulic phenomena (Thompson, 1981). As a result, university and federal government scientists have undertaken a number of oceanographic surveys of these features. In the early 1980s researchers surveying the depths of Knight Inlet with the submersible Pisces IV encountered large fans of gorgonian coral on the flanks of the sill at depths of 65 to 200 m (Tunnicliffe and Syvitski, 1983). Boulders of various sizes were found scattered over the sill, many colonized by impressive fans of Primnoa, the largest 3 m across. The fact that this gorgonian coral was present was noteworthy, but the scientists observed something else extremely curious. Behind some of the boulders were long drag marks, evidence that when the coral fan on a particular boulder became big enough it acted like a sail in the tidal currents. -
Tarantulas and Social Spiders
Tarantulas and Social Spiders: A Tale of Sex and Silk by Jonathan Bull BSc (Hons) MSc ICL Thesis Presented to the Institute of Biology of The University of Nottingham in Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy The University of Nottingham May 2012 DEDICATION To my parents… …because they both said to dedicate it to the other… I dedicate it to both ii ACKNOWLEDGEMENTS First and foremost I would like to thank my supervisor Dr Sara Goodacre for her guidance and support. I am also hugely endebted to Dr Keith Spriggs who became my mentor in the field of RNA and without whom my understanding of the field would have been but a fraction of what it is now. Particular thanks go to Professor John Brookfield, an expert in the field of biological statistics and data retrieval. Likewise with Dr Susan Liddell for her proteomics assistance, a truly remarkable individual on par with Professor Brookfield in being able to simplify even the most complex techniques and analyses. Finally, I would really like to thank Janet Beccaloni for her time and resources at the Natural History Museum, London, permitting me access to the collections therein; ten years on and still a delight. Finally, amongst the greats, Alexander ‘Sasha’ Kondrashov… a true inspiration. I would also like to express my gratitude to those who, although may not have directly contributed, should not be forgotten due to their continued assistance and considerate nature: Dr Chris Wade (five straight hours of help was not uncommon!), Sue Buxton (direct to my bench creepy crawlies), Sheila Keeble (ventures and cleans where others dare not), Alice Young (read/checked my thesis and overcame her arachnophobia!) and all those in the Centre for Biomolecular Sciences. -
Suzane Virtuoso Estudo Fitoquímico E Biológico Das
SUZANE VIRTUOSO ESTUDO FITOQUÍMICO E BIOLÓGICO DAS CASCAS DE Erythrina velutina Willd. - FABACEAE (LEGUMINOSAE - PAPILIONOIDEAE) Dissertação apresentada como requisito parcial à obtenção do grau de Mestre em Ciências Farmacêuticas, curso de Pós - Graduação em Ciências Farmacêuticas, Setor de Ciências da Saúde, Universidade Federal do Paraná. Orientador: Prof. Dr. Obdulio Gomes Miguel Co-Orientadora: Profª. Dra. Marilis Dallarmi Miguel CURITIBA 2005 This document has been created with a DEMO version of PDF Create Convert (http://www.equinox-software.com/products/pdf_create_convert.html) To remove this message please register. Pelo amor, união, apoio e paciência em todos os momentos, dedico este trabalho à minha preciosa família Luiz, Leonilda e Luiz Aurélio. ii This document has been created with a DEMO version of PDF Create Convert (http://www.equinox-software.com/products/pdf_create_convert.html) To remove this message please register. AGRADECIMENTOS Ao meu orientador Prof. Dr. Obdulio Gomes Miguel pela confiança, paciência, estímulo à pesquisa e pelo seu modo especial de ver a vida e as pessoas. À minha co-orientadora Profª. Drª. Marilis Dallarmi Miguel pelo dinamismo, entusiasmo, prontidão em ajudar e encaminhar e, pela confiança depositada. À Universidade Estadual do Oeste do Paraná pela liberação em afastamento parcial, à coordenadora e vice do curso de Farmácia, Nadir Marcondes e Nereida Gioppo pelo apoio e compreensão, a todos os (as) professores (as) e funcionários (as) do curso de Farmácia, em especial aos amigos da Farmácia Escola pelo excelente relacionamento de trabalho, ajuda, momentos alegres e ao meus queridos e compreensivos alunos. Aos professores do Programa de Pós-graduação em Ciências Farmacêuticas da UFPR, que direta ou indiretamente participaram da evolução do trabalho e aos funcionários, especialmente Regina, Hilda e Geni pela ajuda, cafés e bons momentos, também ao Dr. -
Rondonin an Antifungal Peptide from Spider (Acanthoscurria Rondoniae) Haemolymph
CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector Results in Immunology 2 (2012) 66–71 Contents lists available at SciVerse ScienceDirect Results in Immunology journal homepage: www.elsevier.com/locate/rinim Rondonin an antifungal peptide from spider (Acanthoscurria rondoniae) haemolymph K.C.T. Riciluca a,b, R.S.R. Sayegh a, R.L. Melo a, P.I. Silva Jr.a,n a Laborato´rio Especial de Toxinologia Aplicada, Instituto Butantan, 05503-900 Sao~ Paulo – SP, Brazil b Coordenadoria de Controle de Doenc-as – CCD, Sao~ Paulo, Brazil article info abstract Article history: Antimicrobial activities were detected in the haemolymph of the spider Acanthoscurrria rondoniae.A Received 30 January 2012 novel antifungal peptide, rondonin, was purified by reverse phase high performance liquid chromato- Received in revised form graphy (RP-HPLC). Rondonin has an amino acid sequence of IIIQYEGHKH and a molecular mass of 20 March 2012 1236.776 Da. This peptide has identity to a C-terminal fragment of the ‘‘d’’ subunit of haemocyanin Accepted 22 March 2012 from the spiders Eurypelma californicum and Acanthoscurria gomesiana. A synthetic peptide mimicking Available online 2 April 2012 rondonin had identical characteristics to those of the isolated material, confirming its sequence. The Keywords: synthetic peptide was active only against fungus. These data led us to conclude that the antifungal Antimicrobial peptide activity detected in the plasma of these spiders is the result of enzymatic processing of a protein that Haemocyanin fragment delivers oxygen in the haemolymph of many chelicerate. Several studies have suggested that Rondonin haemocyanins are involved in the arthropod immune system, and the activity of this haemocyanin Acanthoscurria rondoniae Spider fragment reinforces this idea. -
Hemolymph and Hemocytes of Tarantula Spiders: Physiological Roles and Potential As Sources of Bioactive Molecules
In: Advances in Animal Science and Zoology. Volume 8 ISBN: 978-1-63483-552-7 Editor: Owen P. Jenkins © 2015 Nova Science Publishers, Inc. No part of this digital document may be reproduced, stored in a retrieval system or transmitted commercially in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services. Chapter 8 HEMOLYMPH AND HEMOCYTES OF TARANTULA SPIDERS: PHYSIOLOGICAL ROLES AND POTENTIAL AS SOURCES OF BIOACTIVE MOLECULES Tatiana Soares, Thiago H. Napoleão, Felipe R. B. Ferreira and Patrícia M. G. Paiva∗ Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil ABSTRACT Arachnids compose the most important and numerous group of chelicerates and include spiders, scorpions, mites and ticks. Some arachnids have a worldwide distribution and can live for more than two decades. This is in part due to their efficient defense system, with an innate immunity that acts as a first line of protection against bacterial, fungal and viral pathogens. The adaptive success of the spiders stimulates the study of their defense mechanisms at cellular and molecular levels with both biological and biotechnological purposes. The hemocytes (plasmatocytes, cyanocytes, granulocytes, prohemocytes, and leberidocytes) of spiders are responsible for phagocytosis, nodulation, and encapsulation of pathogens as well as produce substances that mediate humoral mechanisms such as antimicrobial peptides and factors involved in the coagulation of hemolymph and melanization of microorganisms. -
Useful Brazilian Plants Under the View of the Writer-Naturalist João
Revista Brasileira de Farmacognosia 25 (2015) 437–444 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector www.sbfgnosia.org.br/revista Original Article Useful Brazilian plants under the view of the writer-naturalist João Guimarães Rosa a a,b,c d a,b,∗ Teresinha Lins Chaves , Letícia Ricardo , Juliana de Paula-Souza , Maria das Grac¸ as Lins Brandão a Centro Especializado em Plantas Aromáticas, Medicinais e Tóxicas, Museu de História Natural e Jardim Botânico, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil b Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil c Departamento de Assistencia Farmacêutica e Insumos Estratégicos, Secretaria de Ciência, Tecnologia e Insumos Estratégicos, Ministério da Saúde, Brasília, DF, Brazil d DECEB, Universidade Federal de São João del Rei, Sete Lagoas, MG, Brazil a b s t r a c t a r t i c l e i n f o Article history: This study shows the results of a wide but non-exhaustive review on plants cited in the literacy work Received 15 March 2015 of the writer-naturalist João Guimarães Rosa (J.G. Rosa). Information about popular names and use of Accepted 15 June 2015 plants were recovered through a review in seven works of the author. The assignment of the scientific Available online 10 July 2015 names was based in other previous ethnobotanical studies performed in similar areas of Cerrado in Minas Gerais state. For each species, data about their presence in the Brazilian Official Pharmacopoeia, or use for Keywords: preparing commercial products were checked. -
A Phytochemical and Ethnopharmacological Review of the Genus Erythrina
16 A Phytochemical and Ethnopharmacological Review of the Genus Erythrina João X. de Araújo-Júnior, Mariana S.G. de Oliveira, Pedro G.V. Aquino, Magna S. Alexandre-Moreira and Antônio E.G. Sant’Ana Universidade Federal de Alagoas Brazil 1. Introduction Considered in acient times as a connection to the divine, the use of this medicinal plant is as old as human civilization itself. Whole nations dominated its secrets, often associated with magic and religious rites, searching in nature’s resources to improve life conditions, and increase chances of survival (Herbarium, 2008). In 1978, the World Health Organization (WHO) recognized folk medicine and its beneficial effects to health, during the Alma Ata conference, which published in 1985 that approximatly 80% of the global population, resorted to traditional medicine as their primary health treatment (Herbarium, 2008). Medicinal plants have been used as a means of curing or preventing diseases, now called phytotherapy, in all regions of the world, with regional variations due to the influence of cultural characteristics of the population, as well as its flora, soil and climate (Lewinsohn, 2003). Since the nineteenth century, humanity discovered the endless and diverse therapeutic arsenal present in medicinal plants, due to the discovery of active substances that in their natural state or after chemical transformation showed biological activity, and often already confirmed by popular use and/or proven scientifically (Miguel & Miguel, 2004). According to Yamada (1998) it is necessary to carry out more studies and to propagate medicinal plant utilization as a way to diminish the costs of public health programs since the utilization of these plants may constitute a very useful therapeutic value due their efficacy coupled with low operating costs and the relative ease of obtaining the plants (Matos, 1994). -
Ecological Assessment of Sublittoral Plant Communities in the Northern Gulf of Alaska
ECOLOGICAL ASSESSMENT OF SUBLITTORAL PLANT COMMUNITIES IN THE NORTHERN GULF OF ALASKA by R. J. Rosenthal, D. C. Lees, and T. M. Rosenthal Dames & Moore 510 L Street, Suite 310 Anchorage Alaska 99501 Final Report Outer Continental Shelf Environmental Assessment Program Research Unit 78 September 1977 313 TABLE OF CONTENTS Page LIST OF FIGURES . ● . ● . 317 LIST OF TABLES . ✎ . ✎ ● . 319 INTRODUCTION . ● ● . ✎ . ● ● . ✎ ✎ . 323 GENERAL STUDY OBJEC- VES . ✎ ✎ ● ✎ ● ✎ ● ● ● ✎ . ● . ● 325 ✎ METHODS . ● . ✎ ✎ ✎ ● ✎ ✎ ✎ ✎ ✎ ✎ ● . ✎ ● . 326 THE MARINE PLANT COMMUNITY ✎ . ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ . ✎ ✎ . ✎ 328 RESULTS. ✎ . ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ ✎ . ✎ ✎ . ✎ 331 Description of the Study Site (Latouche Point) ✎ ✎ . ✎ ✎ . ✎ 331 Biological Setting (Algal Assemblage) . ✎ ✎ . ✎ ● . ✎ 334 Epifauna and Trophic Interaction “. ● . ● ✎ . ✎ ✎ . ✎ 360 Seasonal Patterns . ✎ . ✎ ✎ . ✎ ● ● ✎ 379 Description of the Study Site (Zaikof Bay) ✎ . ✎ ✎ . ✎ ✎ ✎ ✎ 387 Biological Setting (Algal Assemblage) . ✎ . ✎ ✎ . ✎ ✎ ✎ ✎ 389 Epifauna and Trophic Interaction . ✎ . ✎ ✎ . ✎ ✎ ✎ ✎ 406 Seasonal Patterns . ✎ . ✎ ✎ . ✎ ✎ ✎ ✎ 419 Description of the Study Site (Macleod Harbor) ✎ ✎ . ✎ ✎ ✎ ✎ 422 Biological Setting (Algal Assemblage) . ✎ ● . ● ✎ ✎ ✎ ✎ 424 Epifauna and Trophic Interaction . ● ✎ . ✎ ✎ ✎ ✎ ✎ 443 Soft Bottom and Faunal Components . ✎ ✎ , ● ● ✎ ✎ ✎ 451 DISCUSSION . ✎ ✎ . ✎ ✎ ✎ ✎ ✎ 452 LITERATURE CITED . ✎ ✎ . ✎ ✎ ✎ ✎ ✎ 458 315 LIST OF FIGURES figure Page 1. Location of study sites in northeastern Gulf of Alaska . 324 2. Study site and subtidal vegetative canopies at Latouche -
Contribuição Ao Conhecimento De Erythrina Velutina Willd. (Fabaceae-Faboideae): Uma Abordagem Farmacobotânica, Química E Farmacologica
UNIVERSIDADE FEDERAL DA PARAÍBA LABORATÓRIO DE TECNOLOGIA FARMACÊUTICA “PROF. DELBY FERNANDES MEDEIROS” PROGRAMA DE PÓS-GRADUAÇÃO EM PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS Contribuição ao Conhecimento de Erythrina velutina Willd. (Fabaceae-Faboideae): Uma abordagem Farmacobotânica, Química e Farmacologica INGRID CHRISTIE ALEXANDRINO RIBEIRO DE MELO João Pessoa - PB 2011 MELO, I. C. A. R Contribuição ao Conhecimento de Erythrina velutina... INGRID CHRISTIE ALEXANDRINO RIBEIRO DE MELO Contribuição ao Conhecimento de Erythrina velutina Willd. (Fabaceae-Faboideae): Uma abordagem Farmacobotânica, Química e Farmacologica Dissertação apresentada ao Programa de Pós- graduação em Produtos Naturais e Sintéticos Bioativos do Centro de Ciências da Saúde, da Universidade Federal da Paraíba, em cumprimento às exigências para a obtenção do título de Mestre em Produtos Naturais e Sintéticos Bioativos. Área de Concentração: Farmacoquímica. Orientadora: Profª. Drª. Maria de Fátima Agra Co-Orientador: Prof. Dr. Eduardo de Jesus Oliveira João Pessoa - PB 2011 2 MELO, I. C. A. R Contribuição ao Conhecimento de Erythrina velutina... INGRID CHRISTIE ALEXANDRINO RIBEIRO DE MELO Contribuição ao Conhecimento de Erythrina velutina Willd. (Fabaceae-Faboideae): Uma abordagem Farmacobotânica, Química e Farmacologica Dissertação aprovada em 25 de Fevereiro de 2011 COMISSÃO EXAMINADORA: _________________________________ Profª.Drª. Maria de Fátima Agra (Universidade Federal da Paraíba) Orientadora _________________________________ Prof.Dr. Rivete Silva de Lima (Universidade Federal da Paraíba) Examinador Externo _________________________________ Profª.Drª. Márcia Regina Piuvezam (Universidade Federal da Paraíba) Examinador Interno 3 MELO, I. C. A. R Contribuição ao Conhecimento de Erythrina velutina... Á minha família, especialmente aos meus pais Maria José e Cristóvão, pelo apoio e motivação e ao meu namorado Leonardo Antunes Trindade, por sua paciência e dedicação. -
(Arenochalina), Biemna and Clathria
marine drugs Review Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria Amr El-Demerdash 1,2,* ID , Mohamed A. Tammam 3,4, Atanas G. Atanasov 5,6 ID , John N. A. Hooper 7 ID , Ali Al-Mourabit 8 and Anake Kijjoa 9,* ID 1 Muséum National d’Histoire Naturelle, Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, UMR 7245 CNRS/MNHN, CP 54, 57 Rue Cuvier, 75005 Paris, France 2 Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt 3 Department of Pharmacognosy and Chemistry of Natural products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece; [email protected] 4 Department of Biochemistry, Faculty of Agriculture, Fayoum University, 63514 Fayoum, Egypt 5 Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria; [email protected] 6 Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland 7 Queensland Museum, Biodiversity & Geosciences Program, P.O. Box 3300, South Brisbane BC, Queensland 4101, Australia; [email protected] 8 ICSN—Institut de Chimie des Substances Naturelles, CNRS UPR 2301, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France; [email protected] 9 ICBAS—Instituto de Ciências Biomédicas Abel Salazar & CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal *