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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on October 1, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from The European List of Essential Medicines for Medical Education, a Protocol for a Modified Delphi Study Journal: BMJ Open ManuscriptFor ID peerbmjopen-2020-045635 review only Article Type: Protocol Date Submitted by the 08-Oct-2020 Author: Complete List of Authors: Donker, Erik; Amsterdam UMC Locatie VUmc, Department of Internal Medicine, section Pharmacotherapy Brinkman, David; Amsterdam UMC Locatie VUmc, Department of Internal Medicine, section Pharmacotherapy Richir, Milan; Amsterdam UMC Locatie VUmc, Department of Internal Medicine, section Pharmacotherapy Papaioannidou, Paraskevi; Aristotle University of Thessaloniki Faculty of Health Sciences, Department of Pharmacology, School of Medicine Likic, Robert; University of Zagreb School of Medicine; University Hospital Centre Zagreb, Unit of Pharmacology Sanz, Emilio ; Universidad de La Laguna, School of Health Science Christiaens, Thierry; Ghent University, Department of Clinical Pharmacology Costa, Joao; University of Lisbon, Department of Pharmacology and http://bmjopen.bmj.com/ Clinical Pharmacology De Ponti, Fabrizio; University of Bologna, Department of Medical and Surgical Sciences Gatti, Milo; University of Bologna, Department of Medical and Surgical Sciences Böttiger, Ylva; Linkopings universitet, Department of Medical and Health Sciences Kramers, Cornelis; Radboud University Medical Center, Department of Pharmacology-Toxicology on October 1, 2021 by guest. Protected copyright. Garners, Sarah; WHO Regional Office for Europe, Health Technologies and Pharmaceuticals Programme Pandit, Rahul; University Medical Centre Utrecht Brain Centre, Department of Translational Neuroscience van Agtmael, Michiel; Amsterdam UMC Locatie VUmc, Department of Internal Medicine, section Pharmacotherapy Tichelaar, Jelle; Amsterdam UMC Locatie VUmc, Department of Internal Medicine, section Pharmacotherapy EDUCATION & TRAINING (see Medical Education & Training), MEDICAL Keywords: EDUCATION & TRAINING, THERAPEUTICS For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 19 BMJ Open 1 BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 For peer review only 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 http://bmjopen.bmj.com/ 34 35 36 37 38 39 40 41 on October 1, 2021 by guest. Protected copyright. 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 19 1 2 3 4 5 BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on October 1, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 19 BMJ Open 1 2 3 The European List of Essential Medicines for Medical Education, a Protocol for a Modified Delphi 4 BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from 5 Study 6 7 8 Corresponding and principle author 9 Erik (Martin) Donker 10 Amsterdam UMC, location VUmc 11 Dept. Internal medicine, Section Pharmacotherapy 12 De Boelelaan 1117 13 1081HV Amsterdam 14 The Netherlands. 15 [email protected] 16 17 18 Co-authors and affiliationsFor peer review only 19 David J. Brinkman1,2 20 Milan C. Richir1,2 21 Paraskevi Papaioannidou3 22 Robert Likic4 23 Emilio J Sanz5 24 Thierry Christiaens6 25 7 26 João N Costa 8 27 Fabrizio De Ponti 28 Milo Gatti8 29 Ylva Böttiger9 30 Cornelis Kramers10 31 Sarah Garner11 32 Rahul Padit12 33 Michiel A van Agtmael1,2 34 1,2 35 Jelle Tichelaar 36 37 1 Department of Internal Medicine, section Pharmacotherapy, Amsterdam UMC, location VUmc, http://bmjopen.bmj.com/ 38 Amsterdam, Netherlands 39 40 2 Research and Expertise Centre in Pharmacotherapy Education (RECIPE), Amsterdam, The 41 Netherlands. 42 43 44 3 Department of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University 45 of Thessaloniki, Thessaloniki, Greece. on October 1, 2021 by guest. Protected copyright. 46 47 4 Unit of Clinical Pharmacology, Department of Internal Medicine, University Hospital Centre Zagreb 48 and University of Zagreb School of Medicine, Zagreb, Croatia 49 50 5 School of Health Science, Universidad de La Laguna, Tenerife, Spain. 51 52 6 Department of Clinical Pharmacology, Ghent University, Ghent, Belgium. 53 54 55 7 Department of Pharmacology and Clinical Pharmacology, University of Lisbon, Lisbon, Portugal 56 57 8 Pharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, 58 University of Bologna 59 60 9 Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 19 1 2 3 10 Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, The 4 Netherlands. BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from 5 6 7 11 Health Technologies and Pharmaceuticals Programme, WHO Regional Office for Europe, WHO, 8 Copenhagen, Denmark. 9 10 12 Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center 11 Utrecht, Utrecht University, Utrecht, The Netherlands 12 13 Word count: 1414 14 15 16 17 18 For peer review only 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on October 1, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 19 BMJ Open 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-045635 on 4 May 2021. Downloaded from 5 Abstract 6 7 8 Introduction 9 10 Junior doctors are responsible for a substantial number of prescribing errors, and final-year medical 11 12 students lack sufficient prescribing knowledge and skills just before they graduate. Various national 13 14 and international projects have been initiated to reform the teaching of clinical pharmacology and 15 16 17 therapeutics (CP&T) during undergraduate medical training. However, there is as yet no list of 18 For peer review only 19 commonly prescribed and available medicines that European doctors should be able to 20 21 independently prescribe safely and effectively without direct supervision.
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