US 2011 0236324A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0236324 A1 Deo (43) Pub. Date: Sep. 29, 2011

(54) PLANT EXTRACTS, COMPOSITIONS plant extracts, Centella plant extracts, and mixtures thereof. CONTAINING SAME, AND USES THEREOF and to the use of these compositions in a variety of applica tions including, for example, cosmetic and/or pharmaceutical (76) Inventor: Namita Deo, Newark, NJ (US) preparations, therapeutic preparations, and personal care preparations. A preferred Bacopa plant extract is obtained (21) Appl. No.: 12/729,718 from Bacopa monniera, and a preferred Centella plant extract (22) Filed: Mar. 23, 2010 is obtained from Centella asiatica. The plant extracts include Sunless tanning active extracts, Sunscreen active extracts, Publication Classification ultraviolet radiation protective extracts, anti-aging active extracts, anti-wrinkle active extracts, moisturizing active (51) Int. Cl. extracts, skin soothing active extracts, skin/hair softening A 6LX 8/97 (2006.01) active extracts, skin/hair treatment active extracts, anti-in A61O 5/00 (2006.01) flammatory active extracts, cosmeceutical preservative A61O 1704 (2006.01) extracts, cosmeceutical stabilizer extracts, antioxidant active A61O 19/00 (2006.01) extracts, free radical inhibitive extracts, cleansing active A61O II/00 (2006.01) extracts, anti-microbial active extracts, anti-fungal active (52) U.S. Cl...... 424/58; 424/725; 424/74; 424/59 extracts, hair coloring active extracts, and oral cleaning/de odoring active extracts. The cosmeceutical compositions (57) ABSTRACT include at least one of a Bacopa plant extract, a Centella plant This disclosure relates to plant extracts selected from Bacopa extract, or a mixture thereof. The plant extracts also include plant extracts, Centella plant extracts, and mixtures thereof; stabilizer active extracts, surfactant active extracts, preserva compositions containing plant extracts selected from Bacopa tive active extracts, and treatment active extracts. Patent Application Publication Sep. 29, 2011 Sheet 1 of 2 US 2011/0236324 A1

on 1 microg/ml -2 microg?ml ----4 microg?ml --8 microg?ml

200 250 300 350 400 Wavelength, mm FIG. 1 Patent Application Publication Sep. 29, 2011 Sheet 2 of 2 US 2011/0236324 A1

FIG 2 US 2011/0236324 A1 Sep. 29, 2011

PLANT EXTRACTS, COMPOSITIONS thereof: a skin/hair softening active extract of a Bacopa plant, CONTAINING SAME, AND USES THEREOF a Centella plant, or a mixture thereof a skin/hair treatment active extract of a Bacopa plant, a Centella plant, or a mixture BACKGROUND thereof, an anti-inflammatory active extract of a Bacopa 0001 1. Field of the Disclosure plant, a Centella plant, or a mixture thereof a cosmeceutical 0002 This disclosure relates to plant extracts selected preservative active extract of a Bacopa plant, a Centella plant, from Bacopa plant extracts, Centella plant extracts, and mix or a mixture thereof; a cosmeceutical stabilizer active extract tures thereof; compositions containing plant extracts selected of a Bacopa plant, a Centella plant, or a mixture thereof; an from Bacopa plant extracts, Centella plant extracts, and mix antioxidant active extract of a Bacopa plant, a Centella plant, tures thereof, and to the use of these compositions in a variety or a mixture thereof, a free radical inhibitive extract of a of applications including, for example, cosmetic and/or phar Bacopa plant, a Centella plant, or a mixture thereof a cleans maceutical preparations, therapeutic preparations, and per ing active extract of a Bacopa plant, a Centella plant, or a Sonal care preparations. mixture thereof, an anti-microbial active extract of a Bacopa 0003 2. Discussion of the Background Art plant, a Centella plant, or a mixture thereof, anti-fungalactive 0004 For many years, plant extracts have been used for extract of a Bacopa plant, a Centella plant, or a mixture medicinal and also for cosmetic purposes in various cultures. thereof: a hair coloring active extract of a Bacopa plant, a New plants are being extracted and the extracts studied for Centella plant, or a mixture thereof, and an oral cleaning/ their cosmetic and pharmaceutical effects in the search to find deodoring active extract of a Bacopa plant, a Centella plant, further plants with a new or different action spectrum. Many or a mixture thereof. plants whose value was not known and which were regarded 0010. This disclosure further relates in part to cosmeceu as exotic and unimportant are now used in the cosmetic and tical compositions that contain, in an effective concentration, pharmaceutical fields. at least one of a Bacopa plant extract, a Centella plant extract, 0005 Today, cosmeceutical preparations are available to or a mixture thereof, and at least one cosmeceutically accept the consumer in a variety of combinations. Consumers not able carrier. only expect these cosmeceuticals to have a certain care effect 0011. This disclosure yet further relates in part to cosme or to eliminate a certain deficiency, they are also increasingly ceutical compositions selected from a Sunless tanning com demanding products which combine several properties and position, a Sunscreen composition, an ultraviolet radiation thus show an improved performance spectrum. There is a protective composition, an anti-aging composition, an anti particular interest in substances which both positively influ wrinkle composition, a moisturizer composition, a skin ence the technical properties of the cosmeceutical product, Soothing composition, a skin/hair softening composition, a Such as storage stability, light stability and formulatability, skin/hair treating composition, an anti-inflammatory compo and at the same time represent active principles that impart, sition, a cosmeceutical preservative composition, a cosme for example, caring, moisturizing, irritation-inhibiting, ceutical stabilizer composition, an antioxidant composition, a inflammation-inhibiting and/or Sun protection properties to free radical inhibitive composition, a cleansing composition, the skin/hair. In addition, consumers demand high dermato an anti-microbial composition, an anti-fungal composition, a logical compatibility and preferably the use of natural prod hair coloring composition, and an oral cleaning/deodoring uctS. composition. 0006. There is also a general demand for cosmeceutical 0012. This disclosure also relates in part to a process for preparations that, by virtue of their special composition, have preparing an extract, said process comprising: (i) providing a high-quality technical properties and which, in addition, are Bacopa plant, a Centella plant or a mixture thereof; (ii) pro distinguished by additional properties for the skin/hair. These viding an extraction medium comprising at least one solvent cosmeceutical preparations should not only be beneficial to selected from the group consisting of water, low molecular consumers, but also should be environmentally friendly, e.g., weight alcohols, esters, hydrocarbons, ketones, halogen-con not a source of synthetic chemical pollution. taining hydrocarbons, and mixtures thereof, and (iii) contact 0007. The present disclosure provides many advantages, ing the Bacopa plant, Centella plant or mixture thereof with which shall become apparent as described below. the extraction medium. 0013 This disclosure further relates in part to a method SUMMARY OF THE DISCLOSURE comprising: (i) providing a Substrate, e.g., skin and/or hair; 0008. This disclosure relates in part to cosmeceutically (ii) providing a composition comprising, in an effective con active extracts selected from the group consisting of Bacopa centration, at least one of a Bacopa plant extract, a Centella plant extracts, Centella plant extracts, and mixtures thereof. plant extract, or a mixture thereof, and at least one cosmeceu 0009. This disclosure also relates in part to cosmeceuti tically acceptable carrier; and (iii) contacting the Substrate cally active extracts selected from the group consisting of a with the composition. Sunless tanning active extract of a Bacopa plant, a Centella 0014. This disclosure yet further relates in part to a method plant, or a mixture thereof a Sunscreen active extract of a of protecting or treating skin and/or hair of humans which Bacopa plant, a Centella plant, or a mixture thereof, an ultra comprises applying to the skin and/or hair a cosmeceutical violet radiation protective extract of a Bacopa plant, a Cen composition comprising, in an effective concentration, at tella plant, or a mixture thereof, an anti-aging active extract of least one of a Bacopa plant extract, a Centella plant extract, or a Bacopa plant, a Centella plant, or a mixture thereof, an a mixture thereof, and at least one cosmeceutically acceptable anti-wrinkle active extract of a Bacopa plant, a Centella plant, carrier. or a mixture thereof a moisturizing active extract of a Bacopa 0015 This disclosure also relates in part to active extracts plant, a Centella plant, or a mixture thereof; a skin soothing selected from the group consisting of Bacopa plant extracts, active extract of a Bacopa plant, a Centella plant, or a mixture Centella plant extracts, and mixtures thereof. US 2011/0236324 A1 Sep. 29, 2011

0016. This disclosure further relates in part to extracts depending on these and other factors. The compositions of selected from the group consisting of a stabilizer active this disclosure can also be administered in combination with extract of a Bacopa plant, a Centella plant, or a mixture one or more additional cosmetic, therapeutic or prophylactic thereof a Surfactant active extract a Bacopa plant, a Centella compounds. As used herein, the term “subject' is preferably plant, or a mixture thereof a preservative active extract a a mammal. Such as a human. Bacopa plant, a Centella plant, or a mixture thereof, and a treatment active extract a Bacopa plant, a Centella plant, or a 0023 This disclosure addresses the problem of providing mixture thereof. The stabilizer active extracts are useful, for cosmetic and/or pharmaceutical preparations that would meet example, as stabilizers in coatings, paints, polymers, plastics, the requirements for cosmetic formulations, such as storage emulsions, and the like. The Surfactant active extracts are stability and dermatological compatibility, and in addition useful, for example, in oil recovery, Soil cleaning, mineral would have improved moisture-regulating, caring and pro separation, agrochemicals, detergents, e.g., laundry and dish tecting properties for human skin/hair. This disclosure uses washing, and the like. The Surfactant active extracts are also plant extracts from plants which had not hitherto been known useful, for example, in food products and in coating and for cosmeceutical applications and to make their ingredients printing ink compositions. The preservative active extracts Suitable for use as active principles in cosmetic and/or phar are useful, for example, as food preservatives. The treatment maceutical preparations. As used herein, "cosmeceutical(s)' active extracts are useful, for example, in fabric and fiber care, refers to cosmetic and/or pharmaceutical preparations. For e.g., UV protection. purposes of this disclosure, cosmeceutical(s) include, but are 0017. This disclosure yet further relates in part to compo not limited to, therapeutic and personal care preparations. sitions that contain at least one of a Bacopa plant extract, a 0024. Bacopa is a genus containing from about 70 to about Centella plant extract, or a mixture thereof. 100 aquatic plants. Bacopa is a member of the Plantaginaceae 0018. This disclosure relates in part to compositions family. It is commonly known as Waterhyssop. Bacopa plants selected from stabilizer compositions (e.g., stabilizer compo are annual or perennial, decumbent or erect Stemmed plants. sitions for coatings, paints, polymers, plastics, emulsions, The leaves are opposite or whorled, and sessile. The leafblade and the like), Surfactant compositions (e.g., Surfactant com is regular, round to linear, and the Venation is palmate or positions useful in oil recovery, Soil cleaning, mineral sepa pinnate. The stems are hairy or smooth. The flowers are ration, agrochemicals, detergents, e.g., laundry and dish produced solitary or in pairs from the leaf axil. The flowers washing, and the like, and also in food products and in coating are usually radially symmetrical having 5 sepals and 5 petals, and printing ink compositions), preservative compositions and are usually white, blue or purple in color. Dispersal and (e.g., preservative compositions useful in food products), and propagation of Bacopa plants is by seeds and stem fragments. treatment compositions (e.g., treatment compositions useful 0025 Bacopa plants are found in tropical and subtropical in fabric and fiber care. regions of the world. For example, Bacopa monniera com 0019. Further objects, features and advantages of the monly grows in marshy areas throughout India, Nepal, Sri present disclosure will be understood by reference to the Lanka, China, Taiwan, and Vietnam. Bacopa plants are also following drawings and detailed description. found in Florida and other southern states of the U.S.A. where they can be grown in damp conditions by a pond or bog BRIEF DESCRIPTION OF THE DRAWINGS garden. 0020 FIG. 1 graphically depicts the UV visible spectra of 0026 Illustrative species include, for example, Bacopa Bacopa monniera extract at different concentrations. As australis, Bacopa Caroliniana (e.g., lemon bacopa, blue water shown in FIG. 1, the Bacopa monniera extract can absorb hyssop and giant bacopa), Bacopa crenata, Bacopa eisenii, light in the entire UV range from 190-400 nm. Bacopa madagascariensis, Bacopa monniera (e.g., water 0021 FIG. 2 graphically depicts the free radical scaveng hyssop, moneywort and herb of grace), Bacopa myriophyl ing activity of Bacopa monniera extract by electron spin loides, Bacopa rotundifolia, and the like. Bacopa extracts resonance (ESR). As shown in FIG. 2, 100 g of Bacopa may be prepared using methods known to those skilled in the monniera extract can scavenge completely 1 mg of nitroxide art. Bacopa extracts may be present in the compositions of free radical tetramethylpiperidinyl-1-oxy (Tempo). this disclosure at a concentration of at least about 0.001%, preferably at least about 1%, and more preferably at least about 5%. The concentration of Bacopa extracts in the com DETAILED DESCRIPTION OF THE positions of this disclosure typically is not greater than about DISCLOSURE 20% or about 30%, and usually is not greater than about 10% 0022. As used herein, an “effective concentration” or or about 15%. “effective amount’ means a quantity of the composition pro 0027. The extracts of the genus Bacopa according to this vided for administration and at a particular dosing regimen, disclosure generally contain ingredients from the group con that is sufficient to achieve a desired appearance, e.g., Sunless sisting of alkaloids (e.g., brahmine and herpestine), Saponins tanning, therapeutic, e.g., moisturizer, and/or prophylactic (e.g., d-mannitol and hersaponin, acid A and monnierin), and effect, e.g., Sunscreen. For example, an effective amount may flavonoids (e.g., luteolin and apigenin). Other extracts result in a desired Sunless tan or the prevention of Sunburn or include betulic acid, Stigmastarol, B-sitosterol, bacosides and a decrease in the symptoms associated with a condition that is bacopasaponins. Illustrative of such bacosides and bacopasa being treated. The amount of the composition administered to ponins include, for example, bacosides A, bacosides B. the subject will depend on the type and severity of the condi bacopaside II, bacopaside I, bacopaside X, bacopasaponin C, tion, and the characteristics of the Subject, where Such char bacopaside N2, bacopasaponin F, bacopasaponin E, bacopa acteristics include general health, age, sex, body weight and side N1, bacopaside III, bacopaside IV, and bacopaside V. tolerance to the active agents in the compositions. Those These ingredients differ incomposition according to the start skilled in the art will be able to determine appropriate dosages ing material and extraction method selected. US 2011/0236324 A1 Sep. 29, 2011

0028 Mixtures of Bacopa plant extracts may also be use extraction are normally used. Any size reduction methods ful in this disclosure. Mixtures of ingredients, e.g., individual known to those skilled in the art, for example crushing in a molecular compositions, from one or more Bacopa plant mortar, may be used. extracts may further be useful in this disclosure. As used 0035. Preferred solvents for the extraction process are herein, "extract(s) are plant extracts including individual organic Solvents, water (distilled or non-distilled, with a tem molecular compositions that can be separated and isolated perature from about 4° C. to about 80° C.) or mixtures of from the plant extracts. organic solvents and water, more particularly low molecular weight alcohols, esters, hydrocarbons, ketones or haloge 0029 Centella is a member of the Mackinlayaceae family. nated hydrocarbons with more or less large water contents. It is commonly known as Gotu Kola. Centella plants are Extraction with water, methanol, ethanol, pentane, hexane, slenderstems and creeping stolons. They are green to reddish heptane, acetone, propylene glycols, polyethylene glycols, green in color and interconnecting one plant to another. Cen ethyl acetate, dichloromethane, trichloromethane and mix tella plants have long-stalked, green, reniform leaves with tures thereof is particularly preferred. The extraction process rounded apices which have a Smooth texture with palmately is generally carried out at 20 to 100°C., preferably at 25 to 90° netted veins. The rootstock consists of rhizomes that are C., and more particularly at 30 to 80° C. creamish in color and covered with root hairs. The flowers are 0036. In one embodiment, the extraction process is carried pinkish to red in color. Each flower bears five stamens and two out in an inert gas atmosphere to avoid oxidation of the styles. Centella plants are found in tropical and Subtropical ingredients of the extract. The extraction times are selected by regions of the world. For example, Centella asiatica com the expert in dependence upon the starting material, the monly grows throughout India, Sri Lanka, northern Australia, extraction process, the extraction temperature and the ratio of Indonesia, Malaysia, and other parts of Asia. Solvent to raw material, etc. After the extraction process, the 0030 Illustrative species include, for example, Centella crude extracts obtained may optionally be subjected to other asiatica, Centella erecta, and the like. Centella extracts may typical steps, such as for example purification, concentration be prepared using methods known to those skilled in the art. and/or decoloration. If desired, the extracts thus prepared Centella extracts may be present in the compositions of this may be subjected, for example, to the selective removal of individual unwanted ingredients. The extraction process may disclosure at a concentration of at least about 0.001%, pref be carried out to any degree, but is usually continued to erably at least about 1%, and more preferably at least about exhaustion. Typical yields (equal to extract dry matter, based 5%. The concentration of Centella extracts in the composi on the quantity of raw material used) in the extraction of dried tions of this disclosure typically is not greater than about 20% plants are in the range from 3 to 20 and more particularly 4 to or about 30%, and usually is not greater than about 10% or 16% by weight. The extraction conditions and the yields of about 15%. the final extracts may be selected according to the desired 0031. The extracts of the genus Centella according to this application. If desired, the extracts may then be subjected, for disclosure generally contain ingredients from the group con example, to spray drying or freeze drying. sisting of triterpene acids and triterpene glycosides. Illustra 0037 Other extraction processes useful in this disclosure tive triterpene acids include, for example, asiatic acid, brah include, for example, Super critical carbon dioxide extraction mic acid, isobrahmic acid, madecassic acid, betulinic acid, and pure carbon dioxide extraction. Such extraction pro and the like. Illustrative triterpene glycosides include, for cesses can be carried out by conventional procedures known example, asiaticoside, madecassoside, brahmoside, brahmi in the art. noside, and the like. These ingredients differ in composition 0038. This disclosure also relates to cosmetic and/or phar according to the starting material and extraction method maceutical preparations that contain an extract selected from selected. the group consisting of a Bacopa plant extract, a Centella 0032 Mixtures of Centella plant extracts may also be plant extract, and mixtures thereof. useful in this disclosure. Mixtures of ingredients, e.g., indi 0039 Cosmetic and/or pharmaceutical preparations based vidual molecular compositions, from one or more Centella on the Bacopa plant, the Centella plant, and/or mixtures plant extracts may further be useful in this disclosure. thereof, show Surprisingly good skin and/or hair care and 0033 Mixtures of at least one Bacopa plant extract and at protecting properties against stress and again environmental least one Centella plant extract may also be useful in this influences coupled with high dermatological compatibility. disclosure. Mixtures of ingredients, e.g., individual molecu In addition, the preparations are effective moisture-regulating lar compositions, from one or more Bacopa plant extracts and skin moisturizers. The preparations are also distinguished by one or more Centella plant extracts may further be useful in a high antioxidation capacity that, on the one hand, protects this disclosure. the skin against inflammatory reactions and against oxida 0034. The extracts to be used in accordance with this dis tion-induced skin aging processes; on the other hand, cos closure may be prepared by known methods of extracting metic preparations are simultaneously protected against oxi plants or parts thereof. Particulars of suitable conventional dative degradation (deterioration). In addition, the products extraction processes, such as maceration, remaceration, thus obtained are capable of preventing damage to human digestion, agitation maceration, Vortex extraction, ultrasonic fibroblasts and keratinocytes by UV radiation and may there extraction, countercurrent extraction, percolation, repercola fore be used as Sun protection factors in cosmetics. tion, evacolation (extraction under reduced pressure), diaco 0040. The quantity of plant extracts used in the prepara lation and Solid/liquid extraction under continuous reflux in a tions mentioned is governed by the concentration of the indi Soxhlet extractor, which are familiar to those skilled in the art vidual ingredients and by the way in which the extracts are and which may all be used. Fresh plants or parts thereof are used. In general, the plant extract is used in a quantity based Suitable as the starting material although dried plants and/or on the final cosmetic and/or pharmaceutical preparation, for plant parts that may be mechanically size-reduced before example, an amount of from about 0.001 to about 25% by US 2011/0236324 A1 Sep. 29, 2011 weight, preferably about 0.01 to about 10% by weight, and the total weight of the composition. In yet another embodi more particularly about 0.1 to about 5% by weight, with the ment, the tanning active system is present in an amount about proviso that the quantities add up to 100% by weight with 0.1 weight% to about 10 weight%, based on the total weight other auxiliaries and additives and with water. The total con of the composition. tent of auxiliaries and additives may be from about 1 to about 0047. The moisturizing system of the sunless tanning 50% by weight and is preferably about 5 to about 40% by compositions can be formulated to provide Substantial mois weight, based on the final cosmetic and/or pharmaceutical turizing to the skin, including simultaneously with the tan preparation. The preparations may be produced by conven ning of the skin and even after the tanning has been com tional processes known in the art. pleted. It has been found that substantial moisturizing to the 0041. This disclosure also relates to the manifold use of skin can be achieved by the moisturizing system of this dis Bacopa plant extracts (e.g., Bacopa monniera plant extracts), closure without the inclusion of mineral oil and/or petrola Centella plant extracts (e.g., Centella asiatica plant extracts), tum. As a result, a composition that is less irritating to sensi and/or mixtures thereof, for example in skin and/or hair care tive skin is formulated. Additionally, the absence of the preparations, particularly against stress; in moisture-regulat mineral oil and petrolatum results in a less occlusive compo ing moisturizers. sition. 0042 Care preparations in the context of this disclosure 0048. The moisturizing system can include at least one are understood to be skin and/or hair care preparations. These Bacopa plant extract, Centella plant extract, and/or mixture care preparations have a cleaning and restoring effect and thereof, and optionally one or more moisturizing components show moisture-regulating and ultraviolet (UV) protection suitable for providing the desired moisturizing effects in the properties. In principle, the extracts according to this disclo absence of mineral oil and petrolatum. In an embodiment, the Sure may be used in a variety of cosmeceutical products. moisturizing system includes two or more moisturizing com 0043. This disclosure provides a sunless tanning compo ponents. In yet another embodiment, the moisturizing system sition having a tanning active system in an amount effective includes at least three moisturizing components. for Sunless tanning. The Sunless tanning composition may 0049 Suitable optional moisturizing components include, optionally have a moisturizing system in an amount effective but are not limited to, one or more polyols, siloxanes, natu for moisturizing skin. rally occurring fats and oils, or any combinations thereof. 0044. The Sunless tanning composition according to this 0050. The one or more polyols that may be used as mois disclosure can be essentially oil-free. In one embodiment, the turizing components include, but are not limited to, glycerin, Sunless tanning composition is oil-free. The term “oil-free'. propylene glycol, butylene glycol, hexylene glycol, penty as used herein, is defined as free of mineral oil and/or petro latum. By formulating the Sunless tanning compositions as lene glycol, caprylyl glycol, Sorbitol, or any combinations oil-free, the compositions are non-irritating to sensitive skin, thereof. have an enhanced skin-feel when applied, and/or are less 0051. The one or more siloxanes that may be used as occlusive to the tanning actives. The Sunless tanning compo moisturizing components in this disclosure include, but are sitions of this disclosure can also be prepared with oil. not limited to, dimethicone, cyclomethicone, phenyl trime 0045. The sunless tanning active system of this disclosure thicone, phenyl dimethicone, cetyl dimethicone, Stearyl includes one or more Sunless tanning actives for imparting a dimethicone, amodimethicone, Coas alkyl dimethicone, tan to the skin. Suitable tanning actives for use in the Sunless Coas alkyl methicone, cetearyl methicone, dimethicone tanning active system of this disclosure include at least one copolyol, cyclopentasiloxane, or any combinations thereof. Bacopa plant extract, Centella plant extract, and/or mixture 0.052 The one or more naturally occurring fats and oils thereof. Other tanning actives that may be present in combi that may be used as moisturizing components in this disclo nation with the Bacopa plant extract, Centella plant extract, sure include, but are not limited to, sheabutter, sheabutter oil, and/or mixture thereof include, for example, dihydroxyac cocoa butter, jojoba butter, aloe butter, olive butter, coconut etone (DHA), erythrulose, melanin, mahakanni, or any com oil.jojoba oil, olive oil, Sunflower seed oil, meadowfoam seed binations thereof. In an embodiment, the tanning actives are oil, macadamia nut oil, sesame oil, borage seed oil, or any at least one Bacopa plant extract, Centella plant extract, and/ combinations thereof. or mixture thereof and DHA. The mixtures can include, for 0053. The moisturizing system can be present in the Sun example, mixtures of Bacopa plant extracts, or mixtures of less tanning composition in an amount about 0.001 weight% ingredients, e.g., individual molecular compositions, from to about 25 weight%, based on the total weight of the com one or more Bacopa plant extracts; mixtures of Centella plant position. In an embodiment, the moisturizing system is extracts, or mixtures of ingredients, e.g., individual molecular present in an amount about 0.01 weight% to about 15 weight compositions, from one or more Centella plant extracts; and %, based on the total weight of the composition. In yet mixtures of Bacopa plant extracts and Centella plant extracts, another embodiment, the moisturizing system is present in an or mixtures of ingredients, e.g., individual molecular compo amount about 0.1 weight% to about 10 weight%, based on sitions, from one or more Bacopa plant extracts and Centella the total weight of the composition. plant extracts. 0054. In one embodiment of the present disclosure, by 0046. The sunless tanning active system is present in the including one or more polyols, one or more siloxanes, and one Sunless tanning compositions of this disclosure in an amount or more naturally occurring fats and oils with the at least one effective for imparting the desired tanning effect in the Bacopa plant extract, Centella plant extract, and/or mixture desired time. A suitable effective amount of the tanning active thereof, in the moisturizing system, the resulting Sunless tan system is about 0.001 weight% to about 25 weight%, based ning composition with this moisturizing system can have the on the total weight of the Sunless tanning composition. In an desired moisturizing properties, while being non-irritating embodiment, the tanning active system is present in an and/or non-occlusive. Also, the composition may unexpect amount about 0.01 weight% to about 15 weight%, based on edly have an enhanced skin-feel. US 2011/0236324 A1 Sep. 29, 2011

0055. In an embodiment, the one or more polyols, one or terephthalydiene dicamphor Sulfonic acid, hydroxy cinnamic more siloxanes, and one or more naturally occurring fats and acid, any derivatives thereof, or any combinations thereof. oils should be present in a weight ratio of about 20:5:1 to 0060. Other suitable additives may include, but are not about 7:2:1. In yet another embodiment, the moisturizing limited to, antioxidants, such as, erythrobic acid, sodium system has dimethicone, glycerin and shea butter present in a metabisulfite, Sodium sulfite, rosemary extract, tocopherol, a ratio of about 14:4.4:1 to about 12:2.5:1. This particular derivative of tocopherol including a tocotriene, carotene, a embodiment, when used to formulate a Sunless tanning com carotenoid, lutein or lutein ester, a carotenoid, a phenolic position according to this disclosure, provides enhanced antioxidant, a bioflavonoid, a plant extract, or any combina moisturizing properties to the composition. tions thereof, keratolytic agents, such as, Salicylic acid, resor 0056. The sunless tanning compositions according to this cinol, peroxide of an organic acid, or any combinations disclosure may further include one or more amphoglycinates thereof anti-inflammatory agents, such as, steroidal and non (amphoacetates). Suitable amphoglycinates include, but are steroidal anti-inflammatory agents, plant extracts that have not limited to Sodium olive amphoacetate, sodium Sunflow demonstrated anti-inflammatory activity, or any combina erseed amphoacetate, sodium cocoabutter amphoacetate, tions thereof, vitamins, such as, Vitamin K, Vitamin C, retinol Sodium sesame amphoacetate, sodium Sweetalmond (vitamin A), tocopherol, or any combinations thereof emol amphoacetate, sodium caproamphoacetate, sodium caprylo lients, such as, cetearyl octanoate, octyl palmitate, glyceryl amphoacetate, Sodium isostearoamphoacetate, sodium lauro monostearate, caprylic trigylceride, capric trigylceride, or amphoacetate, sodium myristoamphoacetate, sodium oleo any combinations thereof humectants, such as, hyaluronic amphoacetate, sodium palmamphoacetate, sodium peanut acid, one or more derivatives of hyaluronic acid, or any com amphoacetate, sodium ricinoleoamphoacetate, sodium binations thereof skin penetration enhancers. Such as, oZone, Stearoamphoacetate, sodium tallow amphoacetate, sodium SEPA, butylene glycol, cis-isomer of an unsaturated fatty undecylenamphoacetate, sodium wheat germamphoacetate, acid, or any combinations thereof emulsifiers, such as, glyc eryl Stearate, cetearyl alcohol, cetyl alcohol, PEG-40 stearate, Sodium cocoylglycinate, or any mixtures thereof. These com or any combinations thereof; thickening agents, such as, Xan pounds are generally available from a variety of Sources or than gum, carbomer, clay, hydroxyethyl cellulose, or any can be prepared by methods known in the art. combinations thereof; preservatives, such as, an alkyl para 0057 The amphoglycinate may be present in the sunless ben, an alcohol, salts of benzoic acid, salts of Sorbic acid, or tanning composition in an amount about 1 weight% to about any combinations thereof colorants, such as, synthetic and 30 weight %, based on the total weight of the composition. natural colorants, henna, caramel, photo-chromic and 0058. The sunless tanning composition may further thermo-chromic colorants and pigments, Surface-treated or include one or more additional components, including, but hydrophobically modified colorants, or any combinations not limited to, Sugars, keto-Sugars, Surface-active agents, thereof, organic acids and their derivatives, such as citric acid, polymers, softening agents, moisturizers, water-proofing glycolic acid, glutamic acid, gluco delta lactone, or any com agents, vitamins, Sweet orange citroflavonoids, hesperitine, binations thereof; chelating agents, such as, disodium EDTA; oZone stressed yeast lysate, Saccharomyces cerevisiae fer pH adjusters, such as, an acid, a base, a buffer, or any com ment filtrate lysate, methylsulfonyl methane (MSM), also binations thereof, to adjust and maintain the pH to about 3.0 known as dimethyl sulfone and methyl sulfone, UV filters, to about 7.5; fragrances; proteins; peptides; and amino acids. skin penetration agents, or any combinations thereof. These 0061 The sunless tanning composition is applicable to a one or more additional components may be present in an variety of personal care product forms including, but not amount up to about 30 weight % of the total weight of the limited to body wash, bar Soap, liquid soap, lather, skin and/or composition. hair care preparation, cream, foam, gel, lotion, Solution, 0059 Suitable UV filters may include, but are not limited emulsion, pomade, mousse, balm, Stick, pump spray, aerosol to, dibenzoylmethane, oxybenzone, Sulisobenzone, dioxy spray, or any combinations thereof. benZone, menthyl anthranilate, para aminobenzoic acid (PABA) ester, benzophenone-3, butyldibenzoylmethane, 0062. The Sunless tanning composition can be organic dimethyl cinnamate, octyl methoxycinnamate, DEA meth Solvent based, water based or it can be an emulsion, including, oxycinnamate, octocrylene, drometrizole trisiloxane, octyl but not limited to, an oil-in-water emulsion or a water-in-oil salicylate, homomethyl salicylate, octyl dimethyl PABA, emulsion. TEA salicylate, 4-methyl benzylidene camphor, 3-ben 0063. This disclosure provides a method of simulta Zylidene camphor, benzylidene camphor Sulfonic acid ester, neously Sunless tanning and moisturizing skin having the step octyl triaZone, phenyl benzimidazole Sulfonic acid ester, of topically applying to the skin an effective amount of a terephthalydiene dicamphor sulfonic acid ester, di-t-butyl Sunless tanning composition having the tanning active system hydroxybenzylidene camphor, ethyl PABA, butylmethoxy and moisturizing system. dibenzoylmethane (avobenzone), terephthalydiene methyl 0064. The preparations according to this disclosure have ene bis-benzotriazoyltetramethylbutyl-phenol, diethylhexyl an excellent skin and/or hair care effect coupled with high 2,6-naphthalate, bis-ethylhexyloxyphenol methoxyphenol dermatological compatibility. They also show high stability, triazine, hydroxy methylphenyl benzotriazole, methylene particularly against oxidative decomposition of the products. bis-benzotriazoyltetramethylbutylphenol, bis-ethylhexylox 0065. This disclosure also relates to the use of the extracts yphenol methoxyphenol triazine, hydroxybenzophenone, a of the Bacopa plant, Centella plant, and/or mixtures thereof, benzotriazole, a dibenzoyl methane, an oxanilide, a hydroxy in Sun protection preparations, e.g., Sunscreens. Sun protec cinnamate, oil dispersible titanium dioxide, oil dispersible tion factors or UV protection factors in the context of this Zinc oxide, a silicone-anchored Sunscreen, para aminoben disclosure are light protection factors that are useful in pro Zoic acid (PABA), salicylic acid, TEA salicylate, benzylidene tecting human skin and/or hair against harmful effects of camphor Sulfonic acid, phenylbenzimidazole Sulfonic acid, direct and indirect solar radiation. The ultraviolet radiation of US 2011/0236324 A1 Sep. 29, 2011

the sun responsible for tanning of the skin is divided into the The UV-A and UV-B filters may of course also be used in the sections UV-C (wavelengths 200-280 nm), UV-B (280-315 form of mixtures. Besides the soluble substances mentioned, nm) and UV-A (315-400 nm). insoluble light-blocking pigments, i.e. finely dispersed metal 0066. The pigmenting of normal skin under the influence oxides or salts, may also be used for this purpose. Examples of solar radiation, i.e. the formation of melanins, is differently of Suitable metal oxides are, in particular, Zinc oxide and effected by UV-B and UV-A. Exposure to UV-A (long-wave titanium dioxide and also oxides of iron, Zirconium oxide, UV) results in darkening of the melanins already present in silicon, manganese, aluminum and cerium and mixtures the epidermis without any sign of harmful effects. It is differ thereof. Silicates (talcum), barium sulfate and zinc stearate ent with so-called short-wave UV (UV-B). This promotes the may be used as salts. The oxides and salts are used in the form formation of so-called late pigment through the reformation of the pigments for skin and/or hair care and skin and/or hair of melanins. However, before the (protective) pigment is protecting emulsions and decorative cosmetics. The particles formed, the skin is exposed to the unfiltered radiation which, should have a mean diameter of less than 100 nm, preferably depending on the exposure time, can lead to reddening of the between 5 and 50 nm and more preferably between 15 and 30 skin (erythema), inflammation of the skin (Sunburn) or even nm. They may be spherical in shape although ellipsoidal blisters. particles or other non-spherical particles may also be used. 0067 Extracts of the Bacopa plant, Centella plant, and/or The pigments may also be surface-treated, i.e. hydrophili mixtures thereof, are used as UV absorbers or light filters that cized or hydrophobicized. Suitable hydrophobic coating convert UV radiation into harmless heat. They may addition materials are, above all, silicones and, among these, espe ally be present in combination with other Sun protection fac cially trialkoxyoctylsilanes or dimethicones. So-called tors or UV protection factors. micro- or nanopigments are preferably used in Sun protection 0068. These other UV protection factors are, for example, products. Micronized zinc oxide is preferably used. organic Substances (light filters) which are liquid or crystal 0071. For sunscreen preparations, the Bacopa plant line at room temperature and which are capable of absorbing extracts, Centella plant extracts, and/or mixtures thereof, may ultraviolet radiation and of releasing the energy absorbed in be present in an amount effective to impart a Sunscreen the form of longer-wave radiation, for example heat. UV-B booster effect in the Sunscreen composition. The Bacopa filters can be oil-soluble or water-soluble. The following are plant extracts, Centella plant extracts, and/or mixtures examples of oil-soluble substances: 3-benzylidene camphor thereof, can increase the effectiveness of conventional Sun or 3-benzylidene norcamphor and derivatives thereof, for screen preparations in protecting human skin and/or hair example 3-(4-methylbenzylidene)-camphor as described in against harmful effects of direct and indirect solar radiation. EP-B10693471: 4-aminobenzoic acid derivatives, preferably 0072 The Sunscreen actives, e.g., Bacopa plant extract, 4-(dimethylamino)-benzoic acid-2-ethylhexyl ester, 4-(dim Centella plant extract, and/or mixture thereof, are present in ethylamino)-benzoic acid-2-octyl ester and 4-(dimethy the Sunscreen compositions of this disclosure in an amount lamino)-benzoic acid amyl ester, esters of cinnamic acid, effective for imparting the desired sunscreen effect in the preferably 4-methoxycinnamic acid-2-ethylhexyl ester, desired time. A suitable effective amount of the sunscreen 4-methoxycinnamic acid propyl ester, 4-methoxycinnamic actives is about 0.001 weight% to about 25 weight%, based acid isoamyl ester, 2-cyano-3.3-phenylcinnamic acid-2-eth on the total weight of the Sunscreen composition. In an ylhexyl ester (octocrylene); esters of salicylic acid, preferably embodiment, the Sunscreen actives are present in an amount salicylic acid-2-ethylhexyl ester, Salicylic acid-4-isopropyl of from about 0.01 weight% to about 15 weight%, based on benzyl ester, salicylic acid homomethyl ester; derivatives of the total weight of the composition. In yet another embodi benzophenone, preferably 2-hydroxy-4-methoxybenzophe ment, the Sunscreen actives are present in an amount of from none, 2-hydroxy-4-methoxy-4-methylbenzophenone, 2,2'- about 0.1 weight% to about 10 weight%, based on the total dihydroxy-4-methoxybenzophenone; esters of benzalma weight of the composition. lonic acid, preferably 4-methoxybenzmalonic acid di-2- 0073. This disclosure also relates to the use of extracts of ethylhexyl ester, triazine derivatives Such as, for example, the Bacopa plant, Centella plant, and/or mixture thereof, in 2,4,6-trianilino-(p-carb-o-2'-ethyl-1'-hexyloxy)-1,3,5-triaz preparations against fibroblast and/or keratinocyte damage ine and octyl triaZone or dioctylbutamido triaZone; propane by UV-A radiation and/or UV-B radiation and as anti-inflam 1,3-diones such as, for example, 1-(4-tert.butylphenyl)-3-(- matory additives. 4'-methoxyphenyl)-propane-1,3-dione; ketotricyclo(5.2.1.0) 0074 UV-A rays penetrate into the dermis where they lead decane derivatives. to oxidative stress that is demonstrated by lipoperoxidation of 0069 Suitable water-soluble substances are 2-phenylben the cytoplasm membranes. The lipoperoxides are degraded to Zimidazole-5-Sulfonic acid and alkali metal, alkaline earth malonaldialdehyde (MDA) which will crosslink many bio metal, ammonium, alkylammonium, alkanolammonium and logical molecules, such as proteins and nuclein bases (en glucammonium salts thereof. Sulfonic acid derivatives of Zyme inhibition or mutagenesis). The extracts of the Bacopa benzophenones, preferably 2-hydroxy-4-methoxybenzophe plant, Centella plant, and/or mixture thereof, according to this none-5-sulfonic acid and salts thereof sulfonic acid deriva disclosure significantly reduce the level of MDA in human tives of 3-benzylidene camphor Such as, for example, 4-(2- fibroblasts induced by UV-A rays and thus show a high capac oxo-3-bornylidenemethyl)-benzene sulfonic acid and ity for reducing the harmful effects of oxidative stress on the 2-methyl-5-(2-oxo-3-bornylidene)-sulfonic acid and salts skin. thereof. 0075 UV-B rays initiate inflammation by activating an 0070 Typical UV-A filters are, in particular, derivatives of enzyme, namely phospholipase A2 or PLA2. This inflamma benzoyl methane Such as, for example, 1-(4-tert.butylphe tion (erythema, odema) is induced by the removal of arachi nyl)-3-(4-methoxyphenyl-)-propane-1,3-dione, 4-tert.butyl donic acid from the phospholipids of the plasma membrane 4'-methoxydibenzoyl methane or 1-phenyl-3-(4-isopropy by the phospholipase. Arachidonic acid is the precursor of the lphenyl)-propane-1,3-dione and the enamine compounds. prostaglandins which cause inflammation and cell membrane US 2011/0236324 A1 Sep. 29, 2011 damage. The prostaglandins E2 (PGE2) are formed by and/or mixture thereof, are present in the skin soothing com cyclooxygenase. The degree of release of the cytoplasm positions of this disclosure in an amount effective for impart enzyme LDH (lactate dehydrogenase) in human kerati ing the desired skin soothing effect in the desired time. A nocytes serves as a marker for cell damage. suitable effective amount of the skin soothing actives is about 0076. The extracts of the Bacopa plant, Centella plant, 0.001 weight % to about 25 weight %, based on the total and/or mixture thereof, reduce the effect of UV-B radiation on weight of the skin soothing composition. In an embodiment, the number of keratinocytes and on the content of released the skin soothing actives are present in an amount of from LDH. Accordingly, the extracts have the ability to reduce cell about 0.01 weight% to about 15 weight%, based on the total membrane damage caused by UV-B radiation. weight of the composition. In yet another embodiment, the 0077. The ultraviolet radiation protective, anti-aging, anti skin soothing actives are present in an amount of from about wrinkle actives, e.g., Bacopa plant extract, Centella plant 0.1 weight% to about 10 weight%, based on the total weight extract, and/or mixture thereof, are present in the ultraviolet of the composition. radiation protective, anti-aging, anti-wrinkle compositions of this disclosure in an amount effective for imparting the I0082. The extracts according to this disclosure may be desired ultraviolet radiation protective, anti-aging, anti used as skin/hair softener additives for cosmetic and/or phar wrinkle effect in the desired time. A suitable effective amount maceutical preparations used in skin/hair care. The skin/hair of the ultraviolet radiation protective, anti-aging, anti-wrinkle softener actives, e.g., Bacopa plant extract, Centella plant actives is about 0.001 weight% to about 25 weight%, based extract, and/or mixture thereof, are present in the skin/hair on the total weight of the ultraviolet radiation protective, softener compositions of this disclosure in an amount effec anti-aging, anti-wrinkle composition. In an embodiment, the tive for imparting the desired skin/hair softener effect in the ultraviolet radiation protective, anti-aging, anti-wrinkle desired time. A suitable effective amount of the skin/hair actives are present in an amount of from about 0.01 weight% softener actives is about 0.001 weight% to about 25 weight to about 15 weight%, based on the total weight of the com %, based on the total weight of the skin/hair softener compo position. In yet another embodiment, the ultraviolet radiation sition. In an embodiment, the skin/hair softener actives are protective, anti-aging, anti-wrinkle actives are present in an present in an amount of from about 0.01 weight% to about 15 amount of from about 0.1 weight % to about 10 weight %, weight%, based on the total weight of the composition. In yet based on the total weight of the composition. another embodiment, the skin/hair softener actives are 0078 Moisture-regulating moisturizers according to this present in an amount of from about 0.1 weight% to about 10 disclosure are understood to be skin care preparations that are weight%, based on the total weight of the composition. intended to regulate skin moisture. In the context of this disclosure, this conforms to the definition of a moisturizer. I0083. The extracts according to this disclosure may be They are substances or mixtures of substances which provide used as skin/hair treatment additives for cosmetic and/or cosmetic and/or pharmaceutical preparations with the ability pharmaceutical preparations used in skin/hair care, e.g., treat to reduce the release of moisture from the stratum corneum ment of acne, dermatitis, eczema, psoriasis, and other skin (horny layer) after application to and spreading over the Sur problems. The skin/hair treatment actives, e.g., Bacopa plant face of the skin. extract, Centella plant extract, and/or mixture thereof, are 007.9 The moisturizers according to this disclosure con present in the skin/hair treatment compositions of this disclo tain extracts of the Bacopa plant, Centella plant, and/or mix Sure in an amount effective for imparting the desired skin/hair ture thereof. Other moisturizers, for example, may be present treating effect in the desired time. A suitable effective amount in combination with the plant extract, including polyglycerol of the skin/hair treatment actives is about 0.001 weight% to fatty acid esters based on C-s fatty acids, for example about 25 weight%, based on the total weight of the skin/hair tetraglyceryl monooleate, triglyceryl diisoStearate; pyro treatment composition. In an embodiment, the skin/hair treat glutamic acid or L-arginine pyroglutamate, L-lysine pyro ment actives are present in an amount of from about 0.01 glutamate; mixtures of amino acids such as, for example, weight% to about 15 weight%, based on the total weight of L-alanine, L-arginine, L-serine, L-threonine; propylene gly the composition. In yet another embodiment, the skin/hair col; acetamide; polysaccharides or hyaluronic acid; castor oil treatment actives are present in an amount of from about 0.1 ethers and Sorbitan esters. weight% to about 10 weight%, based on the total weight of 0080. The moisturizing actives, e.g., Bacopa plant extract, the composition. Centella plant extract, and/or mixture thereof, are present in I0084. In principle, the extracts according to this disclosure the moisturizing compositions of this disclosure in an amount may be used as anti-inflammatory additives for any cosmetic effective for imparting the desired moisturizing effect in the and/or pharmaceutical preparations used against inflamma desired time. A suitable effective amount of the moisturizing tion of the skin and hence in skin care. The inflammation of actives is about 0.001 weight% to about 25 weight%, based the skin may be caused by various factors. on the total weight of the moisturizing composition. In an I0085. The anti-inflammatory actives, e.g., Bacopa plant embodiment, the moisturizing actives are present in an extract, Centella plant extract, and/or mixture thereof, are amount of from about 0.01 weight% to about 15 weight%, present in the anti-inflammatory compositions of this disclo based on the total weight of the composition. In yet another Sure in an amount effective for imparting the desired anti embodiment, the moisturizing actives are present in an inflammatory effect in the desired time. A suitable effective amount of from about 0.1 weight % to about 10 weight %, amount of the anti-inflammatory actives is about 0.001 based on the total weight of the composition. weight% to about 25 weight%, based on the total weight of 0081. The extracts according to this disclosure may be the anti-inflammatory composition. In an embodiment, the used as skin soothing additives for cosmetic and/or pharma anti-inflammatory actives are present in an amount of from ceutical preparations used in skin care. The skin soothing about 0.01 weight% to about 15 weight%, based on the total actives, e.g., Bacopa plant extract, Centella plant extract, weight of the composition. In yet another embodiment, the US 2011/0236324 A1 Sep. 29, 2011

anti-inflammatory actives are present in an amount of from 0090 Besides the use of extracts of the Bacopa plant, about 0.1 weight% to about 10 weight%, based on the total Centella plant, and/or mixture thereof, as antioxidants, other weight of the composition. already known antioxidants may also be used. One possible I0086. The extracts according to this disclosure may be use of the antioxidants, for example in cosmetic and/or phar used as preservatives for cosmetic and/or pharmaceutical maceutical preparations, is their use as secondary Sun protec preparations used in skin and/or hair care. The preservative tion factors because antioxidants are capable of interrupting actives, e.g., Bacopa plant extract, Centella plant extract, the photochemical reaction chain which is initiated when UV and/or mixture thereof, are present in the cosmetic and/or rays penetrate into the skin. Besides the plant extract accord pharmaceutical compositions of this disclosure in an amount ing to this disclosure, typical examples are amino acids (for effective for imparting the desired preservative effect in the example glycine, alanine, arginine, serine, threonine, histi desired time. A suitable effective amount of the preservative dine, tyrosine, tryptophane) and derivatives thereof, imida actives is about 0.001 weight% to about 25 weight%, based Zoles (for example urocanic acid) and derivatives thereof, on the total weight of the cosmetic and/or pharmaceutical peptides, such as D.L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example anserine), carotinoids, composition. In an embodiment, the preservative actives are carotenes (for example C-carotene, 3-carotene, lycopene, present in an amount of from about 0.01 weight% to about 15 lutein) and derivatives thereof, chlorogenic acid and deriva weight%, based on the total weight of the composition. In yet tives thereof, liponic acid and derivatives thereof (for another embodiment, the preservative actives are present in example dihydroliponic acid), aurothioglucose, propylthiou an amount of from about 0.1 weight% to about 10 weight%, racil and other thiols (for example thioredoxine, glutathione, based on the total weight of the composition. cysteine, cystine, cystamine and glycosyl, N-acetyl, methyl, 0087. The extracts according to this disclosure may be ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, Y-lino used as Stabilizers for cosmetic and/or pharmaceutical prepa leyl, cholesteryl and glyceryl esters thereof) and their salts, rations used in skin and/or hair care. The stabilizer actives, dilaurylthiodipropionate, distearylthiodipropionate, thio e.g., Bacopa plant extract, Centella plant extract, and/or mix dipropionic acid and derivatives thereof (esters, ethers, pep ture thereof, are present in the cosmetic and/or pharmaceuti tides, lipids, nucleotides, nucleosides and salts) and Sulfox cal compositions of this disclosure in an amount effective for imine compounds (for example butionine Sulfoximines, imparting the desired stabilizer effect in the desired time. A homocysteine Sulfoximine, butionine Sulfones, penta-, hexa suitable effective amount of the stabilizer actives is about and hepta-thionine Sulfoximine) in very small compatible 0.001 weight % to about 25 weight %, based on the total dosages (for example pmole to Lmole/kg), also (metal) chela weight of the cosmetic and/or pharmaceutical composition. tors (for example C-hydroxyfatty acids, palmitic acid, phytic In an embodiment, the stabilizer actives are present in an acid, lactoferrine), C-hydroxy acids (for example citric acid, amount of from about 0.01 weight% to about 15 weight%, lactic acid, malic acid), humic acid, bile acid, bile extracts, based on the total weight of the composition. In yet another bilirubin, biliverdin, boldin, boldo extract, EDTA, EGTA and embodiment, the stabilizer actives are present in an amount of derivatives thereof, unsaturated fatty acids and derivatives from about 0.1 weight% to about 10 weight%, based on the thereof (for example Y-linolenic acid, linoleic acid, oleic total weight of the composition. acid), folic acid and derivatives thereof, ubiquinone and 0088. In an embodiment, cosmeceutical compositions are ubiquinol and derivatives thereof, vitamin C and derivatives provided to be topically applied to the skin and/or hair, and thereof (for example ascorbyl palmitate, Mgascorbyl phos absorbed through the skin and/or hair. The cosmeceutical phate, ascorbyl acetate), tocopherols and derivatives (for compositions of this disclosure can be formulated for topical example vitamin E acetate), Vitamin A and derivatives (vita administration and applied to the skin, and absorbed through min. A palmitate) and coniferyl benzoate of benzoin resin, the skin, so as to reduce oxidative stress, e.g., compositions rutinic acid and derivatives thereof, C-glycosyl rutin, ferulic having antioxidant properties that have the ability to termi acid, furfurylidene glucitol, carnosine, butyl hydroxytoluene, nate free radical chain reactions in biological systems. Oxi butyl hydroxyanisole, nordihydroguaiac resin acid, nordihy dative stress is a result of animbalance between antioxidative droguaiaretic acid, trihydroxybutyrophenone, uric acid and defense systems and the formation of reactive oxygen species derivatives thereof, mannose and derivatives thereof, super including free radicals. Oxidative stress can damage DNA, oxid-dismutase, Zinc and derivatives thereof (for example proteins, lipids and carbohydrates and may also alter intrac ZnO, ZnSO), selenium and derivatives thereof (for example ellular signaling processes. The damage can contribute to cell selenium methionine), stilbenes and derivatives thereof (for injury and death, accelerate the aging process, and promote example stilbene oxide, trans-stilbene oxide) and derivatives many diseases, such as cancer, cardiovascular diseases, and of these active substances suitable for the purposes of this Parkinson's disease. disclosure (salts, esters, ethers, Sugars, nucleotides, nucleo 0089. This disclosure also relates to the use of extracts of sides, peptides and lipids). the Bacopa plant, Centella plant, and/or mixture thereof, as 0091. The UV protection factors or antioxidants, e.g., antioxidants or radical traps. Antioxidants in the context of Bacopa plant extract, Centella plant extract, and/or mixture this disclosure are oxidation inhibitors that can be isolated thereof, are present in the UV protection/antioxidant compo from the Bacopa plant, Centella plant, and/or mixture sitions of this disclosure in an amount effective for imparting thereof. Antioxidants are capable of inhibiting or preventing the desired UV protection/antioxidant effect in the desired changes caused by the effects of oxygen and other oxidative time. A suitable effective amount of the UV protection/anti processes in the substances to be protected. The effect of oxidantactives is about 0.001 weight% to about 25 weight%, antioxidants consists mainly in their acting as radical traps for based on the total weight of the UV protection/antioxidant the free radicals occurring during autoxidation. The extracts composition. In an embodiment, the UV protection/antioxi of the Bacopa plant, Centella plant extract, and/or mixture dant actives are present in an amount of from about 0.01 thereof, exhibit desirable free radical scavenging activity. weight% to about 15 weight%, based on the total weight of US 2011/0236324 A1 Sep. 29, 2011 the composition. In yet another embodiment, the UV protec spray, and combinations thereof. Among other applications, tion/antioxidant actives are present in an amount of from the deodorants are useful for removing/controlling body odor. about 0.1 weight% to about 10 weight%, based on the total 0097. The compositions of this disclosure comprise a weight of the composition. "cosmeceutically acceptable carrier” to act as a diluant, dis persant or carrier for the ingredients, so as to facilitate its 0092. The extracts according to this disclosure may be distribution and uptake when the composition is applied to the used as cleansing additives for cosmetic and/or pharmaceu skin and/or hair. Vehicles other thanor in addition to water can tical preparations used in skin and/or hair care, e.g., hair, skin, include liquid or Solid emollients, solvents, humectants, body and hand cleansers. The cleansing actives, e.g., Bacopa thickeners, powders, and perfumes. plant extract, Centella plant extract, and/or mixture thereof, 0098. The cosmeceutically acceptable carrier will usually are present in the cleansing compositions of this disclosure in form from 0.001% to 99.9%, preferably from 25% to 80% by an amount effective for imparting the desired cleansing effect weight of the composition, and can, in the absence of other in the desired time. A suitable effective amount of the cleans cosmeceutical adjuncts, form the balance of the composition. ing actives is about 0.001 weight % to about 25 weight %, 0099. The compositions may be in the form of aqueous, based on the total weight of the cleansing composition. In an aqueous/alcoholic or oily solutions; dispersions of the lotion embodiment, the cleansing actives are presentinanamount of or serum type; anhydrous or lipophilic gels; emulsions of from about 0.01 weight% to about 15 weight%, based on the liquid or semi-liquid consistency, which are obtained by dis total weight of the composition. In yet another embodiment, persion of a fatty phase in an aqueous phase or conversely an the cleansing actives are present in an amount of from about aqueous phase in a fatty phase; or Suspensions or emulsions of 0.1 weight% to about 10 weight%, based on the total weight Smooth, semi-solid or Solid consistency of the cream or gel of the composition. type. These compositions are formulated according to the 0093. The extracts according to this disclosure may be conventional techniques known in the art. used as anti-microbial and/or anti-fungal additives for cos 0100 When the compositions of this disclosure are for metic and/or pharmaceutical preparations used in skin and/or mulated as an emulsion, the proportion of the fatty phase may hair care. The anti-microbial and/or anti-fungal actives, e.g., range from 5% to 80% by weight, and preferably from 5% to Bacopa plant extract, Centella plant extract, and/or mixture 50% by weight, relative to the total weight of the composi thereof, are present in the anti-microbial and/or anti-fungal tion. Oils, emulsifiers and co-emulsifiers incorporated in the compositions of this disclosure in an amount effective for composition in emulsion form are selected from among those imparting the desired anti-microbial and/or anti-fungal effect used conventionally in the cosmetic or dermatological field. in the desired time. A suitable effective amount of the anti The emulsifier and coemulsifier may be present in the com microbial and/or anti-fungal actives is about 0.001 weight% position at a proportion ranging from 0.3% to 30% by weight, to about 25 weight %, based on the total weight of the anti and preferably from 0.5% to 20% by weight, relative to the microbial and/or anti-fungal composition. In an embodiment, total weight of the composition. the anti-microbial and/or anti-fungal actives are present in an 0101. When the compositions of this disclosure are for amount of from about 0.01 weight% to about 15 weight%, mulated as an oily solution or gel, the fatty phase may con based on the total weight of the composition. In yet another stitute more than about 50%, more than about 75%, or even embodiment, the anti-microbial and/oranti-fungalactives are more than about 90% of the total weight of the composition. present in an amount of from about 0.1 weight% to about 10 0102 The extracts according to this disclosure may be weight%, based on the total weight of the composition. used in cosmetic and/or pharmaceutical preparations such as, 0094. In an embodiment, the anti-microbial and/or anti for example, foam baths, shower baths, creams, gels, lotions, fungal additives can be used in cleansers, for example, hair, alcoholic and aqueous/alcoholic Solutions, emulsions, wax/ skin, body, and/or hand cleansers, to impart anti-microbial fat compounds, powders or ointments. These preparations and/or anti-fungal properties to the cleanser. Such cleansers may also contain Surfactants, oil components, emulsifiers, can be useful for removing body odor. pearlizing waxes, consistency factors, thickeners, Superfat 0095. The extracts according to this disclosure may be ting agents, stabilizers, polymers, silicone compounds, fats, used as additives in hair color applications. The additive waxes, lecithins, phospholipids, biogenic agents, odor actives, e.g., Bacopa plant extract, Centella plant extract, absorbers, film formers, Swelling agents, hydrotropes, solu and/or mixture thereof, are present in the hair color compo bilizers, preservatives, perfume oils, dyes and the like, as sitions of this disclosure in an amount effective for imparting further auxiliaries and additives. the desired hair coloring effect in the desired time. A suitable (0103 Suitable surfactants include anionic, nonionic, cat effective amount of the additive actives is about 0.001 weight ionic and/or amphoteric or Zwitterionic Surfactants which % to about 25 weight%, based on the total weight of the hair may be present in the preparations in quantities of normally coloring composition. In an embodiment, the additive actives about 1 to 70% by weight, preferably 5 to 50% by weight and are present in an amount of from about 0.01 weight% to about more preferably 10 to 30% by weight. The surfactants are 15 weight%, based on the total weight of the composition. In conventional materials known in the art. yet another embodiment, the additive actives are present in an 0104 Typical examples of anionic Surfactants are soaps, amount of from about 0.1 weight % to about 10 weight %, alkylbenzenesulfonates, alkanesulfonates, olefin Sulfonates, based on the total weight of the composition. alkylether Sulfonates, glycerol ether Sulfonates, C.-methyl 0096. The cosmeceutical compositions of this disclosure ester sulfonates, sulfofatty acids, alkyl sulfates, fatty alcohol are typically used in topical form. The topical form can be a ether sulfates, glycerol ether sulfates, fatty acid ether sulfates, Solution, emulsion, serum, skin and/or hair cleanser, body hydroxy mixed ether Sulfates, monoglyceride (ether) Sulfates, wash, body Scrub, bar Soap, liquid soap, shampoo lather, fatty acid amide (ether) sulfates, mono- and dialkyl Sulfo Suc deodorant, skin and/or hair care preparation, foam, mousse, cinates, mono- and dialkyl SulfoSuccinamates, Sulfotriglyc cream, lotion, pomade, balm, Stick, gel, pump spray, aerosol erides, amide Soaps, ether carboxylic acids and salts thereof, US 2011/0236324 A1 Sep. 29, 2011

fatty acid isothionates, fatty acid sarcosinates, fatty acid tau 0109 The oil components may be present in the compo rides, N-acylamino acids Such as, for example, acyl lacty sitions of this disclosure in quantities of normally about 1 to lates, acyl tartrates, acylglutamates and acyl aspartates, alkyl about 90% by weight or greater, preferably about 5 to about oligoglucoside Sulfates, protein fatty acid condensates (par 75% by weight and more preferably about 10 to about 50% by ticularly wheat-based vegetable products) and alkyl (ether) weight. The oil components are conventional materials phosphates. known in the art. 0105 Typical examples of nonionic surfactants are fatty 0110 Suitable emulsifiers include, for example, nonionic alcohol polyglycol ethers, alkylphenol polyglycol ethers, Surfactants from at least one of the following groups: products fatty acid polyglycol esters, fatty acid amide polyglycol of the addition of 2 to 30 moles of ethylene oxide and/or 0 to ethers, fatty amine polyglycol ethers, alkoxylated triglycer 5 moles of propylene oxide onto linear Cs fatty alcohols, ides, mixed ethers and mixed formals, optionally partly oxi C-2 fatty acids and alkyl phenols containing 8 to 15 carbon dized alk(en)yl oligoglycosides or glucuronic acid deriva atoms in the alkyl group and alkylamines containing 8 to 22 tives, fatty acid-N-alkyl glucamides, protein hydrolyzates carbon atoms in the alkyl group; alkyl and/or alkenyl oli (particularly wheat-based vegetable products), polyol fatty goglycosides containing 8 to 22 carbon atoms in the alkyl acid esters, Sugar esters, Sorbitan esters, polysorbates and group and ethoxylated analogs thereof, adducts of 1 to 15 amine oxides. moles of ethylene oxide with castor oil and/or hydrogenated 010.6 Typical examples of cationic surfactants are quater castor oil; adducts of 15 to 60 moles of ethylene oxide with nary ammonium compounds, for example dimethyl distearyl castor oil and/or hydrogenated castor oil; partial esters of ammonium chloride, and esterquats, more particularly quat glycerol and/or Sorbitan with unsaturated, linear or Saturated, ernized fatty acid trialkanolamine ester salts. Typical branched fatty acids containing 12 to 22 carbon atoms and/or examples of amphoteric or Zwitterionic Surfactants are alky hydroxycarboxylic acids containing 3 to 18 carbonatoms and 1betaines, alkylamidobetaines, aminopropionates, aminogly adducts thereof with 1 to 30 moles of ethylene oxide; partial cinates, imidazolinium betaines and Sulfobetaines. esters of polyglycerol (average degree of self-condensation 2 0107 Suitable oil components are, for example, alcohols to 8), polyethylene glycol (molecular weight 400 to 5,000), based on fatty alcohols containing 6 to 18 and preferably 8 to trimethylolpropane, pentaerythritol, Sugar alcohols (for 10 carbon atoms, esters of linear C fatty acids with linear example sorbitol), alkylglucosides (for example methylglu C fatty alcohols, esters of branched C. carboxylic acids coside, butylglucoside, lauryl glucoside) and polyglucosides with linear C fatty alcohols such as, for example, myristyl (for example cellulose) with Saturated and/or unsaturated, myristate, myristyl palmitate, myristyl stearate, myristyl linear or branched fatty acids containing 12 to 22 carbon isostearate, myristyl oleate, myristyl behenate, myristyl eru atoms and/or hydroxycarboxylic acids containing 3 to 18 cate, cetyl myristate, cetyl palmitate, cetyl Stearate, cetyl carbon atoms and adducts thereof with 1 to 30 moles of isostearate, cetyl oleate, cetyl behenate, cetyl erucate, Stearyl ethylene oxide; mixed esters of pentaerythritol, fatty acids, myristate, Stearyl palmitate, Stearyl Stearate, Stearyl isostear citric acid and fatty alcohol and/or mixed esters offatty acids ate, Stearyl oleate, Stearyl behenate, Stearylerucate, isostearyl containing 6 to 22 carbon atoms, methylglucose and polyols, myristate, isostearyl palmitate, isostearyl Stearate, isostearyl preferably glycerol or polyglycerol, mono-, di- and trialkyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl phosphates and mono-, di- and/or tri-PEG-alkyl phosphates oleate, oleyl myristate, oleyl palmitate, oleyl Stearate, oleyl and salts thereof, wool wax alcohols, polysiloxane/polyalkyl/ isostearate, oleyl oleate, oleyl behenate, oleylerucate, behe polyether copolymers and corresponding derivatives, block nyl myristate, behenyl palmitate, behenyl stearate, behenyl copolymers, for example polyethylene glycol-30 dipolyhy isostearate, behenyl oleate, behenyl behenate, behenyl eru droxyStearate; polymer emulsifiers; polyalkylene glycols and cate, erucyl myristate, erucyl palmitate, erucyl Stearate, glycerol carbonate. erucyl isostearate, erucyl oleate, erucyl behenate and erucyl 0111. The addition products of ethylene oxide and/or pro erucate. pylene oxide with fatty alcohols, fatty acids, alkylphenols or 0108. Also suitable are esters of linear C fatty acids with castor oil are known commercially available products. with branched alcohols, more particularly 2-ethylhexanol, They are homolog mixtures of which the average degree of esters of Css alkylhydroxycarboxylic acids with linear or alkoxylation corresponds to the ratio between the quantities branched C-2 fatty alcohols, more especially dioctyl malate, of ethylene oxide and/or propylene oxide and substrate with esters of linear and/or branched fatty acids with polyhydric which the addition reaction is carried out. Ca?s fatty acid alcohols (for example propylene glycol, dimer diol or trimer monoesters and diesters of adducts of ethylene oxide with triol), triglycerides based on Co fatty acids, liquid mono-, glycerol may be useful. di- and triglyceride mixtures based on Cs fatty acids, esters 0112 Alkyl and/or alkenyl oligoglycosides can be useful. of C-2 fatty alcohols with aromatic carboxylic acids, more They are produced in particular by reacting glucose or oli particularly benzoic acid, esters of C. dicarboxylic acids gosaccharides with primary alcohols containing 8 to 18 car with linear or branched alcohols containing 1 to 22 carbon bon atoms. So far as the glycoside unit is concerned, both atoms or polyols containing 2 to 10 carbon atoms and 2 to 6 monoglycosides in which a cyclic Sugar unit is attached to the hydroxyl groups, vegetable oils, branched primary alcohols, fatty alcohol by a glycoside bond and oligomeric glycosides Substituted cyclohexanes, carbonates, esters of benzoic acid with a degree of oligomerization of preferably up to about 8 with linear and/or branched C. alcohols, linear or are Suitable. The degree of oligomerization is a statistical branched, symmetrical or nonsymmetrical dialkyl ethers con mean value on which the homolog distribution typical of such taining 6 to 22 carbon atoms per alkyl group, ring opening technical products is based. products of epoxidized fatty acid esters with polyols, silicone 0113 Typical examples of suitable partial glycerides are oils (cyclomethicone, silicon methicone types, etc.) and/or hydroxyStearic acid monoglyceride, hydroxy Stearic acid dig aliphatic or naphthenic hydrocarbons, for example squalane, lyceride, isostearic acid monoglyceride, isostearic acid dig squalene or dialkyl cyclohexanes. lyceride, oleic acid monoglyceride, oleic acid diglyceride, US 2011/0236324 A1 Sep. 29, 2011

ricinoleic acid monoglyceride, ricinoleic acid diglyceride, 0117 Cationic surfactants are also suitable emulsifiers, linoleic acid monoglyceride, linoleic acid diglyceride, lino those of the esterquat type, preferably methyl-quaternized lenic acid monoglyceride, linolenic acid diglyceride, erucic difatty acid triethanolamine ester salts, being preferred. acid monoglyceride, erucic acid diglyceride, tartaric acid 0118. The emulsifiers may be present in the compositions monoglyceride, tartaric acid diglyceride, citric acid of this disclosure in quantities of normally about 0.01 to about monoglyceride, citric acid diglyceride, malic acid monoglyc 40% by weight, preferably about 0.5 to about 25% by weight, eride, malic acid diglyceride and technical mixtures thereof and more preferably about 0.5 to about 20% by weight. The which may still contain Small quantities of triglyceride from emulsifiers are conventional materials known in the art. the production process. Addition products of 1 to 30 and 0119 Typical examples of fats include glycerides, i.e. preferably 5 to 10 moles of ethylene oxide with the partial Solid or liquid, vegetable or animal products which consist glycerides mentioned are also suitable. essentially of mixed glycerol esters of higher fatty acids. 0114 Suitable sorbitan esters are sorbitan monoisostear Suitable waxes are natural waxes such as, for example, can ate, Sorbitan sesquisostearate, Sorbitan diisostearate, Sorbi delilla wax, carnauba wax, Japan wax, espartograss wax, cork tan triisoStearate, Sorbitan monooleate, Sorbitan sesquioleate, wax, guaruma wax, rice oil wax, Sugar cane wax, ouricury Sorbitan dioleate, Sorbitan trioleate, Sorbitan monoerucate, wax, montan wax, beeswax, shellac wax, spermaceti, lanolin Sorbitan sesquierucate, Sorbitandierucate, Sorbitan trierucate, (wool wax), uropygial fat, ceresine, oZocerite (earth wax), Sorbitan monoricinoleate, Sorbitan sesquiricinoleate, Sorbitan petrolatum, paraffin waxes and microwaxes; chemically diricinoleate, Sorbitan triricinoleate, Sorbitan monohydroxyS modified waxes (hard waxes) Such as, for example, montan tearate, Sorbitan sesquihydroxy Stearate, Sorbitan dihydroxyS ester waxes, Sasol waxes, hydrogenated jojoba waxes and tearate, Sorbitan trihydroxy Stearate, Sorbitan monotartrate, synthetic waxes such as, for example, polyalkylene waxes Sorbitan sesquitartrate, Sorbitan ditartrate, Sorbitan tritartrate, and polyethylene glycol waxes. Besides the fats, other Suit Sorbitan monocitrate, Sorbitan sesquicitrate, Sorbitan dici able additives are fat-like Substances, such as lecithins and trate, Sorbitan tricitrate, Sorbitan monomaleate, Sorbitan ses phospholipids. Lecithins are known in the art as glycerophos quimaleate, Sorbitan dimaleate, Sorbitan trimaleate and tech pholipids which are formed from fatty acids, glycerol, phos nical mixtures thereof. Addition products of 1 to 30 and phoric acid and choline by esterification. Examples of natural preferably 5 to 10 moles of ethylene oxide with the sorbitan lecithins are the kephalins which are also known as phospha esters mentioned are also suitable. tidic acids and which are derivatives of 1,2-diacyl-sn-glyc 0115 Typical examples of suitable polyglycerol esters are erol-3-phosphoric acids. By contrast, phospholipids are gen polyglyceryl-2 dipolyhydroxystearate, polyglycerin-3-dii erally understood to be mono- and preferably diesters of SoStearate, polyglyceryl-4 isostearate, polyglyceryl-3' oleate, phosphoric acid with glycerol (glycero-phosphates) which disoStearoyl polyglyceryl-3 diisoStearate, polyglyceryl-3 are normally classed as fats. Sphingosines and sphingolipids methylglucose distearate, polyglyceryl-3 beeswax, polyglyc are also Suitable. eryl-4 caprate, polyglyceryl-3 cetyl ether, polyglyceryl-3 dis 0.120. The fats may be present in the compositions of this tearate and polyglyceryl polyricinoleate, polyglyceryl dime disclosure in quantities of normally about 0.01 to about 40% rate isostearate and mixtures thereof. Examples of other by weight, preferably about 0.5 to about 25% by weight, and Suitable polyolesters are the mono-, di- and triesters of trim more preferably about 0.5 to about 20% by weight. The fats ethylolpropane or pentaerythritol with lauric acid, cocofatty are conventional materials known in the art. acid, tallow fatty acid, palmitic acid, Stearic acid, oleic acid, I0121 Suitable pearlescing waxes are, for example, alky behenic acid and the like optionally reacted with 1 to 30 moles lene glycol esters, especially ethylene glycol distearate; fatty of ethylene oxide. acid alkanolamides, especially cocofatty acid diethanola 0116. Other suitable emulsifiers are Zwitterionic surfac mide; partial glycerides, especially Stearic acid monoglycer tants. Zwitterionic Surfactants are surface-active compounds ide; esters of polybasic, optionally hydroxy-Substituted car which contain at least one quaternary ammonium group and boxylic acids with fatty alcohols containing 6 to 22 carbon at least one carboxylate and one Sulfonate group in the mol atoms, especially long-chain esters of tartaric acid; fatty com ecule. Particularly suitable Zwitterionic surfactants are the pounds, such as for example fatty alcohols, fatty ketones, so-called betaines, such as the N-alkyl-N,N-dimethyl ammo fatty aldehydes, fatty ethers and fatty carbonates which con nium glycinates, for example cocoalkyl dimethyl ammonium tain in all at least 24 carbon atoms, especially laurone and glycinate, N-acylaminopropyl-N,N-dimethyl ammonium distearylether, fatty acids, such as Stearic acid, hydroxys glycinates, for example cocoacylaminopropyl dimethyl tearic acid or behenic acid, ring opening products of olefin ammonium glycinate, and 2-alkyl-3-carboxymethyl-3-hy epoxides containing 12 to 22 carbonatoms with fatty alcohols droxyethylimidazolines containing 8 to 18 carbon atoms in containing 12 to 22 carbonatoms and/or polyols containing 2 the alkyl or acyl group and cocoacylaminoethylhydroxyethyl to 15 carbon atoms and 2 to 10 hydroxyl groups and mixtures carboxymethyl glycinate. Ampholytic Surfactants are also thereof. Suitable emulsifiers. Ampholytic Surfactants are Surface-ac 0.122 The pearlescing waxes may be present in the com tive compounds which, in addition to a Css alkyl or acyl positions of this disclosure in quantities of normally about group, contain at least one free amino group and at least one 0.01 to about 20% by weight, preferably about 0.5 to about —COOH- or —SOH group in the molecule and which 15% by weight, and more preferably about 0.5 to about 10% are capable of forming inner salts. Examples of Suitable by weight. The pearlescing waxes are conventional materials ampholytic Surfactants are N-alkyl glycines, N-alkyl propi known in the art. onic acids, N-alkylaminobutyric acids, N-alkyliminodipropi I0123. The consistency factors mainly used are fatty alco onic acids, N-hydroxyethyl-N-alkylamidopropyl glycines, hols or hydroxyfatty alcohols containing 12 to 22 and pref N-alkyl taurines, N-alkyl sarcosines, 2-alkylaminopropionic erably 16 to 18 carbonatoms and also partial glycerides, fatty acids and alkylaminoacetic acids containing around 8 to 18 acids or hydroxyfatty acids. A combination of these Sub carbon atoms in the alkyl group. stances with alkyl oligoglucosides and/or fatty acid N-methyl US 2011/0236324 A1 Sep. 29, 2011 glucamides of the same chain length and/or polyglycerol 0.132. The cationic polymers may be present in the com poly-12-hydroxyStearates is preferably used. positions of this disclosure in quantities of normally about 0.124. The consistency factors may be present in the com 0.01 to about 20% by weight, preferably about 0.5 to about positions of this disclosure in quantities of normally about 15% by weight, and more preferably about 0.5 to about 10% 0.01 to about 20% by weight, preferably about 0.5 to about by weight. The cationic polymers are conventional materials 15% by weight, and more preferably about 0.5 to about 10% known in the art. by weight. The consistency factors are conventional materials 0.133 Suitable anionic, Zwitterionic, amphoteric and non known in the art. ionic polymers are, for example, vinyl acetate/crotonic acid 0.125 Suitable thickeners are, for example, hydrophilic copolymers, vinyl pyrrolidone/vinyl acrylate copolymers, silicas, polysaccharides, more especially Xanthan gum, guar vinyl acetate/butyl maleate/isobornyl acrylate copolymers, guar, agar-agar, alginates and tyloses, carboxymethyl cellu methyl vinylether/maleic anhydride copolymers and esters lose and hydroxyethyl cellulose, also relatively high molecu thereof, uncrosslinked and polyol-crosslinked polyacrylic lar weight polyethylene glycol monoesters and diesters of acids, acrylamidopropyl trimethylammonium chloride/acry fatty acids, polyacrylates; polyacrylamides, polyvinyl alco late copolymers, octylacrylamide/methyl methacrylate?tert.- hol and polyvinyl pyrrolidone, Surfactants such as, for butylaminoethyl methacrylate/2-hydroxypropyl methacry example, ethoxylated fatty acid glycerides, esters of fatty late copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone? acids with polyols, for example pentaerythritol or trimethylol vinyl acetate copolymers, vinyl pyrrolidone/ propane, narrow-range fatty alcohol ethoxylates or alkyl oli dimethylaminoethyl methacrylate/vinyl caprolactam goglucosides and electrolytes. Such as Sodium chloride and terpolymers and optionally derivatized cellulose ethers and ammonium chloride. silicones. 0126 The thickeners may be present in the compositions I0134. The anionic, Zwitterionic, amphoteric and nonionic of this disclosure in quantities of normally about 0.01 to about polymers may be present in the compositions of this disclo 20% by weight, preferably about 0.5 to about 15% by weight, sure in quantities of normally about 0.01 to about 20% by and more preferably about 0.5 to about 10% by weight. The weight, preferably about 0.5 to about 15% by weight, and thickeners are conventional materials known in the art. more preferably about 0.5 to about 10% by weight. The 0127 Superfatting agents may be selected from such sub anionic, Zwitterionic, amphoteric and nonionic polymers are stances as, for example, lanolin and lecithin and also poly conventional materials known in the art. ethoxylated or acylated lanolin and lecithin derivatives, 0.135 Suitable silicone compounds are, for example, dim polyol fatty acid esters, monoglycerides and fatty acid ethyl polysiloxanes, methylphenyl polysiloxanes, cyclic sili alkanolamides, the fatty acid alkanolamides also serving as cones and amino-, fatty acid-, alcohol-, polyether-, epoxy-, foam stabilizers. fluorine-, glycoside- and/or alkyl-modified silicone com 0128. The superfatting agents may be present in the com pounds which may be both liquid and resin-like at room positions of this disclosure in quantities of normally about temperature. Other Suitable silicone compounds are simethi 0.01 to about 20% by weight, preferably about 0.5 to about cones which are mixtures of dimethicones with an average 15% by weight, and more preferably about 0.5 to about 10% chain length of 200 to 300 dimethylsiloxane units and hydro by weight. The Superfatting agents are conventional materials genated silicates. known in the art. 0.136 The silicone compounds may be present in the com 0129 Metal salts offatty acids such as, for example, mag positions of this disclosure in quantities of normally about nesium, aluminum and/or Zinc Stearate or ricinoleate may be 0.01 to about 20% by weight, preferably about 0.5 to about used as stabilizers. 15% by weight, and more preferably about 0.5 to about 10% 0130. The stabilizers may be present in the compositions by weight. The silicone compounds are conventional materi of this disclosure in quantities of normally about 0.01 to about als known in the art. 20% by weight, preferably about 0.5 to about 15% by weight, 0.137 In the context of this disclosure, biogenic agents are, and more preferably about 0.5 to about 10% by weight. The for example, tocopherol, tocopherol acetate, tocopherol stabilizers are conventional materials known in the art. palmitate, ascorbic acid, deoxyribonucleic acid, retinol, bis 0131 Suitable cationic polymers are, for example, cat abolol, allantoin, phytantriol, panthenol, amino acids, cera ionic cellulose derivatives such as, for example, quaternized mides, pseudoceramides, essential oils, other plant extracts hydroxyethyl cellulose, cationic starch, copolymers of diallyl and vitamin complexes. ammonium salts and acrylamides, quaternized vinyl pyrroli 0.138. The biogenic agents may be present in the compo done/vinylimidazole polymers, condensation products of sitions of this disclosure in quantities of normally about 0.01 polyglycols and amines, quaternized collagen polypeptides to about 20% by weight, preferably about 0.5 to about 15% by Such as, for example, lauryidimonium hydroxypropyl hydro weight, and more preferably about 0.5 to about 10% by lyzed collagen, quaternized wheat polypeptides, polyethyl weight. The biogenic agents are conventional materials eneimine, cationic silicone polymers such as, for example, known in the art. amodimethicone, copolymers of adipic acid and dimethy 0.139 Suitable odor absorbers are substances which are lamino-hydroxypropyl diethylenetriamine, copolymers of capable of absorbing and largely retaining the odor-forming acrylic acid with dimethyl diallyl ammonium chloride, compounds. They reduce the partial pressure of the individual polyaminopolyamides and crosslinked water-soluble poly components and thus also reduce the rate at which they mers thereof, cationic chitin derivatives such as, for example, spread. An important requirement in this regard is that per quaternized chitosan, optionally in micro-crystalline distri fumes must remain unimpaired. They contain, for example, a bution, condensation products of dihaloalkyls, for example complex Zinc salt of ricinoleic acid or special perfumes of dibromobutane, with bis-dialkylamines, for example bis largely neutral odor Such as, for example, extracts of ladanum dimethylamino-1,3-propane, cationic guar gum, and quater or styrax or certainabietic acid derivatives as their principal nized ammonium salt polymers. component. Odor maskers are perfumes or perfume oils US 2011/0236324 A1 Sep. 29, 2011 which, besides their odor-masking function, impart their par 0145 The film formers may be present in the composi ticular perfume note to the cosmeceutical product. Suitable tions of this disclosure in quantities of normally about 0.01 to perfume oils are, for example, mixtures of natural and Syn about 20% by weight, preferably about 0.5 to about 15% by thetic perfumes. Natural perfumes include the extracts of weight, and more preferably about 0.5 to about 10% by blossoms, stems and leaves, fruits, fruit peel, roots, woods, weight. The film formers are conventional materials known in herbs and grasses, needles and branches, resins and balsams. the art. Animal raw materials, for example civet and beaver, may also 0146 Suitable Swelling agents for aqueous phases are be used. Typical synthetic perfume compounds are products montmorillonites, clay minerals, pemulen and alkyl-modi of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon fied carbopol types. type. 0140. Examples of perfume compounds of the ester type 0147 The swelling agents may be present in the compo are benzyl acetate, p-tert.butyl cyclohexylacetate, linallyl sitions of this disclosure in quantities of normally about 0.01 acetate, phenyl ethyl acetate, linallyl benzoate, benzyl for to about 20% by weight, preferably about 0.5 to about 15% by mate, allyl cyclohexyl propionate, Styrallyl propionate and weight, and more preferably about 0.5 to about 10% by benzyl salicylate. Ethers include, for example, benzyl ethyl weight. The Swelling agents are conventional materials ether while aldehydes include, for example, the linear alka known in the art. nals containing 8 to 18 carbon atoms, citral, citronellal, cit 0.148. In addition, hydrotropes, for example ethanol, iso ronellyloxyacetaldehyde, cyclamen aldehyde, hydroxy-cit propyl alcohol or polyols, may be used to improve flow ronellal, lilial and bourgeonal. Examples of suitable ketones behavior. Suitable polyols preferably contain 2 to 15 carbon are the ionones and methyl cedryl ketone. Suitable alcohols atoms and at least two hydroxyl groups. The polyols may are anethol, citronellol, eugenol, isoeugenol, geraniol, lina contain other functional groups, more especially amino lool, phenylethyl alcohol and terpineol. The hydrocarbons groups, or may be modified with nitrogen. Typical examples mainly include the terpenes and balsams. However, it is pre are glycerol; alkylene glycols such as, for example, ethylene ferred to use mixtures of different perfume compounds glycol, diethylene glycol, propylene glycol, butylene glycol, which, together, produce an agreeable fragrance. Other Suit hexylene glycol and polyethylene glycols with an average able perfume oils are essential oils of relatively low volatility molecular weight of 100 to 1000 dalton; technical oligoglyc which are mostly used as aroma components. Examples are erol mixtures with a degree of self-condensation of 1.5 to 10 sage oil, camomile oil, clove oil, melissa oil, mint oil, cinna Such as, for example, technical diglycerol mixtures with a mon leaf oil, lime-blossom oil, juniper berry oil, Vetiver oil, diglycerol content of 40 to 50% by weight; methylol com olibanum oil, galbanum oil, ladanum oil and lavendin oil. The pounds such as, in particular, trimethylol ethane, trimethylol following are preferably used either individually or in the propane, trimethylol butane, pentaerythritol and dipen form of mixtures: bergamotoil, dihydromyrcenol, lilial, lyral, taerythritol; lower alkyl glucosides, particularly those con citronellol, phenylethyl alcohol, C-hexyl-cinnamaldehyde, taining 1 to 8 carbon atoms in the alkyl group, for example geraniol, benzyl acetone, cyclamen aldehyde, linalool, bois methyl and butylglucoside; Sugar alcohols containing 5 to 12 ambrene forte, ambroxan, indole, hedione, Sandelice, citrus carbon atoms, for example Sorbitol or mannitol, Sugars con oil, mandarin oil, orange oil, allylamylglycolate, cyclovertal, taining 5 to 12 carbon atoms, for example glucose or Sucrose; lavendin oil, clary oil, B-damascone, geranium oil bourbon, amino Sugars, for example glucamine; dialcoholamines. Such cyclohexyl salicylate, evernyl, iraldein Y, phenylacetic acid, as diethanolamine or 2-aminopropane-1,3-diol. geranyl acetate, benzyl acetate, rose oxide, romilat, irotyland 014.9 The hydrotropes may be present in the compositions floramat. of this disclosure in quantities of normally about 0.01 to about 0141. The odor absorbers may be present in the composi 20% by weight, preferably about 0.5 to about 15% by weight, tions of this disclosure in quantities of normally about 0.01 to and more preferably about 0.5 to about 10% by weight. The about 20% by weight, preferably about 0.5 to about 15% by hydrotropes are conventional materials known in the art. weight, and more preferably about 0.5 to about 10% by 0150. Suitable preservatives are, for example, phenoxy weight. The odor absorbers are conventional materials known ethanol, formaldehyde Solution, parabens, pentanediolor Sor in the art. bic acid. 0142 Typical water-soluble additives are, for example, 0151. The preservatives may be present in the composi preservatives, water-soluble perfumes, pH adjusters, for tions of this disclosure in quantities of normally about 0.01 to example buffer mixtures, water-soluble thickeners, for about 20% by weight, preferably about 0.5 to about 15% by example water-soluble natural or synthetic polymers such as, weight, and more preferably about 0.5 to about 10% by for example, Xanthan gum, hydroxyethyl cellulose, polyvinyl weight. The preservatives are conventional materials known pyrrolidone or high molecular weight polyethylene oxides. in the art. 0143. The water soluble additives may be present in the 0152 Suitable perfume oils are mixtures of natural and compositions of this disclosure in quantities of normally synthetic perfumes. Natural perfumes include the extracts of about 0.01 to about 20% by weight, preferably about 0.5 to blossoms (lily, lavender, rose, jasmine, neroli, ylang-ylang), about 15% by weight, and more preferably about 0.5 to about stems and leaves (geranium, patchouli, petitgrain), fruits (an 10% by weight. The water-soluble additives are conventional ise, coriander, caraway, juniper), fruit peel (bergamot, lemon, materials known in the art. orange), roots (nutmeg, angelica, celery, Cardamon, Costus, 0144 Standard film formers are, for example, chitosan, iris, calmus), woods (pinewood, sandalwood, guaiac wood, microcrystalline chitosan, quaternized chitosan, polyvinyl cedarwood, rosewood), herbs and grasses (tarragon, lemon pyrrolidone, vinyl pyrrolidone/vinyl acetate copolymers, grass, sage, thyme), needles and branches (spruce, fir, pine, polymers of the acrylic acid series, quaternary cellulose dwarf pine), resins and balsams (galbanum, elemi, benzoin, derivatives, collagen, hyaluronic acid and salts thereof and myrrh, olibanum, opoponax). Animal raw materials, for similar compounds. example civet and beaver, may also be used. US 2011/0236324 A1 Sep. 29, 2011

0153. Typical synthetic perfume compounds are products enzymes and calcium. Ingredients also include water, Sweet of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon eners such as Sorbitol. Sucralose, Sodium saccharine, and type. Examples of perfume compounds of the ester type are xylitol (which doubles as a bacterial inhibitor). Sometimes benzyl acetate, phenoxyethyl isobutyrate, p-tert.butyl cyclo alcohol is added, as a carrier for flavor, and to contribute an hexylacetate, linallyl acetate, dimethyl benzyl carbinyl anti-bacterial effect. Commercial mouthwashes usually con acetate, phenyl ethyl acetate, linallyl benzoate, benzyl for tain a preservative such as sodium benzoate to preserve fresh mate, ethylmethyl phenylglycinate, allyl cyclohexyl propi ness once the container has been opened. Many brands con onate, Styrallyl propionate and benzyl salicylate. Ethers tain odor-elimination agents such as oxidizers, as well as include, for example, benzyl ethyl ether while aldehydes odor-preventing agents such as Zinc ion to keep future bad include, for example, the linear alkanals containing 8 to 18 breath from developing. carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, 0160 The extracts according to this disclosure may be cyclamen aldehyde, hydroxycitronellal, lilial and bour used as cleaning and/or deodoring additives for mouth geonal. Examples of Suitable ketones are the ionones, washes, mouth rinses, and the like. The cleaning and/or O-isomethylionone and methyl cedryl ketone. Suitable alco deodoring actives, e.g., Bacopa plant extract, Centella plant hols are anethol, citronellol, eugenol, isoeugenol, geraniol, extract, and/or mixture thereof, are present in the mouth linalool, phenylethyl alcohol and terpineol. The hydrocar washes, mouth rinses, and the like, in an amount effective for bons mainly include the terpenes and balsams. However, it is imparting the desired cleaning and/or deodoring effect in the preferred to use mixtures of different perfume compounds desired time. A suitable effective amount of the cleaning which, together, produce an agreeable fragrance. and/or deodoring actives is about 0.001 weight% to about 25 0154) Other suitable perfume oils are essential oils of rela weight%, based on the total weight of the composition. In an tively low volatility which are mostly used as aroma compo embodiment, the cleaning and/or deodoring actives are nents. Examples are sage oil, camomile oil, clove oil, melissa present in an amount of from about 0.01 weight% to about 15 oil, mint oil, cinnamon leaf oil, lime-blossom oil, juniper weight%, based on the total weight of the composition. In yet berry oil, Vetiver oil, olibanum oil, galbanum oil, ladanum oil another embodiment, the cleaning and/or deodoring actives and lavendin oil. The following are preferably used either are present in an amount of from about 0.1 weight% to about individually or in the form of mixtures: bergamot oil, dihy 10 weight%, based on the total weight of the composition. dromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, 0.161 This disclosure also relates to a process for prepar C.-hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen ing an extract of the Bacopa plant, Centella plant, and/or aldehyde, linalool, boisambrene forte, ambroxan, indole, mixture thereof, in which solvents or mixtures of solvents hedione, Sandelice, citrus oil, mandarin oil, orange oil, ally selected from the group consisting of distilled or nondistilled lamylglycolate, cyclovertal, lavendin oil, clary oil, B-dam water, low molecular weight alcohols, esters or hydrocarbons ascone, geranium oilbourbon, cyclohexyl salicylate, iraldein are used for extraction of the plant. y, phenylacetic acid, geranyl acetate, benzyl acetate, rose 0162. It has been found that selective Bacopa natural prod oxide, romillat, irotyl and floramat. ucts, Centella natural products, and/or mixture thereof, have 0155 The perfume oils may be present in the composi the exceptional quality to absorb the UV light completely, for tions of this disclosure in quantities of normally about 0.01 to example between 190 and 400 nm. These Bacopa natural about 20% by weight, preferably about 0.5 to about 15% by products, Centella natural products, and/or mixture thereof, weight, and more preferably about 0.5 to about 10% by not only can absorb UV lights, but also can Scavenge free weight. The perfume oils are conventional materials known in radicals efficiently. For example, the free radical scavenging the art. capacity of these Bacopa products, Centella products, and/or 0156 Suitable dyestuffs and colorants are any of the sub mixture thereof, can be more than 100 times superior to the stances suitable and approved for cosmetic and/or pharma presently available antioxidants. Furthermore, a few of these ceutical purposes. The dyestuffs and colorants are conven products found to have a strong moisturizing as well as Sun tional materials known in the art. The dyestuffs and colorants less tanning and Sunscreen properties. The presence of these are normally used in concentrations of 0.001 to 0.1% by properties makes these Bacopa products, Centella products, weight, based on the mixture as a whole. and/or mixture thereof, a perfect environmentally benign can 0157. The compositions of this disclosure can also include didate for the cosmeceuticals and UV additive applications. one or more other plant extracts having desired cosmeceutical 0163. It has further been found that Bacopa natural prod or other properties. Illustrative of other plant extracts include, ucts, Centella natural products, and/or mixture thereof, have for example, Withania somnifera, Silybum marianum, Cur the capability to absorb both UVA and UVB radiation in cuma longa, Camelia sinensis, and the like. addition to having the free radical scavenging capacity. Many 0158. The other plant extracts may be present in the com of the Bacopa natural products, Centella natural products, positions of this disclosure in quantities of normally about and/or mixture thereof, are water soluble, therefore, it is pos 0.001 to about 20% by weight, preferably about 0.01 to about sible to formulate oil free sunscreens in addition to fulfilling 15% by weight, and more preferably about 0.1 to about 10% all other requirements. by weight. The other plant extracts are known in the art. 0164. It has also been found that the Bacopa natural prod 0159. Oral hygiene involves keeping the mouth and teeth ucts, Centella natural products, and/or mixture thereof, have clean to prevent dental problems and bad breath. Mouth strong antioxidant properties which have the capability to washes and mouth rinses are products used to enhance oral terminate free radical chain reactions in biological systems hygiene. Active ingredients in commercial brands of mouth and therefore may provide additional health benefits to con wash can include thymol, eucalyptol, hexetidine, methyl sali Sumers. Severe oxidative stress, a result of an imbalance cylate, menthol, chlorhexidine gluconate, benzalkonium between antioxidative defense systems and the formation of chloride, cetylpyridinium chloride, methylparaben, hydrogen reactive oxygen species including free radicals, can damage peroxide, domiphen bromide and sometimes fluoride, DNA, proteins, lipids and carbohydrate and may also alter US 2011/0236324 A1 Sep. 29, 2011 intracellular signaling processes. The damage could contrib total weight of the composition. In yet another embodiment, ute to cell injury and death, accelerate the aging process, and the preservative actives are present in an amount of from promote many diseases, such as cancer, cardiovascular dis about 0.1 weight% to about 10 weight%, based on the total eases, and Parkinson's disease. weight of the composition. 0.165. The Bacopa natural products, Centella natural prod 0173 Coatings, paints, polymers, plastics, emulsions, and ucts, and/or mixture thereof, of this disclosure can be utilized in many cosmeceutical applications. Preferred cosmeceutical the like, can have, for example, a light stabilizer (i.e., a applications include, for example, the following: Bacopa plant extract, Centella plant extract, and/or mixture 0166 (i) Sunscreen lotions; since the Bacopa extracts, thereof) in combination with a UV absorber for optimal pro Centella extracts, and/or mixture thereof, have the capability tection of coatings and plastics. The ratio of UV absorber and to protect skin and/or hair against three types of ultraviolet stabilizer depends on the concentration of pigments used in radiations, i.e., ultraviolet-B (UV-B) and ultraviolet-A (UV the materials, e.g., paint. Clear coatings require higher A) that reach earth's atmosphere from the sun and ultravio amounts of UV absorber, whereas opaque pigmented coat let-C (UV-C) that does not reach the earth atmosphere, the ings require higher amounts of stabilizer. Bacopa extracts, Centella extracts, and/or mixture thereof, 0.174. The extracts according to this disclosure may be can be used to make Sun protecting lotions; used as stabilizers, e.g., light stabilizers, for coatings, paints, 0167 (ii) anti aging or anti wrinkling creams; the Bacopa polymers, plastics, emulsions, and the like. The stabilizer extract, Centella extract, and/or mixture thereof, products actives, e.g., Bacopa plant extract, Centella plant extract, have natural antioxidant properties in addition to having the and/or mixture thereof, are present in the coatings, paints, capacity to Scavenge radicals causing damage to human cells; polymers, plastics, emulsions, and the like, in an amount these properties are known to decelerate the aging process; effective for imparting the desired stabilizer effect in the 0168 (iii) Sunless tanning agents; the Bacopa extract, desired time. A suitable effective amount of the stabilizer Centella extract, and/or mixture thereof, products have the actives is about 0.001 weight% to about 25 weight%, based capacity to tan skin in absence of Sunlight; and on the total weight of the composition. In an embodiment, the 0169 (iv) moisturizers; the Bacopa extract, Centella stabilizer actives are present in an amount of from about 0.01 extract, and/or mixture thereof, products have the potential to weight% to about 15 weight%, based on the total weight of protect the skin from the water loss which ultimately reduces the composition. In yet another embodiment, the stabilizer the risks of many skin diseases. actives are present in an amount of from about 0.1 weight% 0170 These Bacopa plant based products, Centella plant to about 10 weight%, based on the total weight of the com based products, and/or mixture thereof, not only have the position. potential to replace currently used unhealthy synthetic chemi cals for cosmeceuticals and other UV additive applications, 0.175. Oil recovery, e.g., enhanced oil recovery, consists of but also provide additional benefits to the health of consum injecting a displacing fluid into injection wells in order to ers, and help to prevent further synthetic chemical pollution in displace the oil and gas in a reservoir towards producing the environment. wells. An enhanced oil recovery technique involves chemical 0171 The Bacopa plant based products, Centella plant flooding in which an alkaline-Surfactant-polymer formula based products, and/or mixture thereof, can also be utilized in tion is injected into the reservoir. The polymer is used to other applications. For example, the Bacopa plant based improve the Sweep efficiency of the invading fluid by chang products, Centella plant based products, and/or mixture ing the mobility ratio between the invading fluid versus the thereof, can be used as food additives, e.g., preservatives. The displaced fluid. The Surfactant is present to change the wet Bacopa plant based products, Centella plant based products, tability of the formation rock if necessary and to reduce the and/or mixture thereof, can be used as stabilizers for coatings, interfacial tension. paints, polymers, plastics, emulsions, and the like. The 0176 The extracts, e.g., isolated molecules from the Bacopa plant based products, Centella plant based products, extracts, according to this disclosure may be used as Surfac and/or mixture thereof, can also be used as Surfactants for oil tants in oil recovery formulations. The Surfactant actives, e.g., recovery, Soil cleaning, mineral separation, agrochemical Bacopa plant extract, Centella plant extract, and/or mixture applications, and the like. Further, the Bacopa plant based thereof, are present in the oil recovery formulations in an products, Centella plant based products, and/or mixture amount effective for imparting the desired surfactant effect in thereof, can be useful in detergent applications, e.g., laundry the desired time. A suitable effective amount of the surfactant and dishwashing detergents. The Bacopa plant based prod actives is about 0.001 weight% to about 25 weight%, based ucts, Centella plant based products, and/or mixture thereof, on the total weight of the composition. In an embodiment, the can also be used as additives, e.g., Surfactants, in food prod surfactant actives are present in an amount of from about 0.01 ucts and for coating and printing ink compositions. weight% to about 15 weight%, based on the total weight of 0172. The extracts according to this disclosure may be the composition. In yet another embodiment, the Surfactant used as food additives, e.g., preservatives. The food preser actives are present in an amount of from about 0.1 weight% Vative actives, e.g., Bacopa plant extract, Centella plant to about 10 weight%, based on the total weight of the com extract, and/or mixture thereof, are present in the food pre position. servative compositions of this disclosure in an amount effec 0177 Soil cleaning processes are used in for the treatment tive for imparting the desired preservative effect in the desired of contaminated soil, for example, oil contaminated soil. Soil time. A suitable effective amount of the preservative actives is cleaning or washing is a water-based process for Scrubbing about 0.001 weight% to about 25 weight%, based on the total soils ex situ to remove contaminants. Contaminants sorbed weight of the food preservative composition. In an embodi onto fine Soil particles are separated from bulk soil in an ment, the preservative actives are present in an amount of aqueous-based system on the basis of particle size. The soil from about 0.01 weight% to about 15 weight%, based on the cleaning formulation includes wash water that may be aug US 2011/0236324 A1 Sep. 29, 2011 mented with a basic leaching agent, Surfactant, pH adjust 0183 Laundry detergent typically consists of (i) ionic and ment, or chelating agent to help remove organics and heavy anionic Surfactants which act as the detergent to remove the metals. dirt from the clothes, (ii) perfume, (iii) phosphors which make clothes appear whiter. Laundry powders have anticaking 0.178 The extracts according to this disclosure may be agents to prevent the powder becoming one large lump in the used as Surfactants in soil cleaning formulations. The Surfac presence of moisture. For liquid detergents, the bulk of the tant actives, e.g., Bacopa plant extract, Centella plant extract, product is water, for concentrated liquids, somewhat less and/or mixture thereof, are present in the Soil cleaning for water, but still the product is mostly water. Detergents may mulations in an amount effective for imparting the desired have other additives such as bleaches and fabric softeners. surfactant effect in the desired time. A suitable effective 0.184 Dishwashing detergents are usually a highly foam amount of the surfactant actives is about 0.001 weight% to ing mixture of Surfactants with low skin irritation, and are about 25 weight%, based on the total weight of the compo primarily used for washing of glasses, plates, cutlery, and sition. In an embodiment, the Surfactant actives are present in cooking utensils. The reduced Surface tension of dishwashing an amount of from about 0.01 weight% to about 15 weight%, water, and increasing solubility of Surfactant mixtures, allows based on the total weight of the composition. In yet another the soap to run off the dishes in a dish rack and the remaining embodiment, the Surfactant actives are present in an amount traces of dishwashing liquid can dry off fast and do not pose of from about 0.1 weight% to about 10 weight%, based on any health or taste problems. the total weight of the composition. 0185. The extracts according to this disclosure may be 0179 Mineral separation is important in the mining indus used as Surfactants for detergents such as laundry detergents, try, for example, in the separation of valuable minerals from dishwashing detergents, general household cleaning deter complex ores. Surface characteristics of minerals are often gents, and the like. The Surfactant actives, e.g., Bacopa plant complex due to changes during particle preparation as well as extract, Centella plant extract, and/or mixture thereof, are interactions with the Surrounding environment. The key to present in the detergents in an amount effective for imparting their separation lies in manipulation of the Surface character the desired surfactant effect in the desired time. A suitable istics by treatment with selected reagents. Controlled adsorp effective amount of the surfactant actives is about 0.001 tion of Surfactants, polymers or a combination of both can weight% to about 25 weight%, based on the total weight of modify the surface of the mineral to achieve the desired the composition. In an embodiment, the Surfactant actives are separation results. present in an amount of from about 0.01 weight% to about 15 0180. The extracts according to this disclosure may be weight%, based on the total weight of the composition. In yet used as Surfactants in mineral separation formulations. The another embodiment, the Surfactant actives are present in an Surfactant actives, e.g., Bacopa plant extract, Centella plant amount of from about 0.1 weight % to about 10 weight %, extract, and/or mixture thereof, are present in the mineral based on the total weight of the composition. separation formulations in an amount effective for imparting 0186 The properties of many food products such as vol the desired surfactant effect in the desired time. A suitable ume and texture are dependent upon the interaction of various effective amount of the surfactant actives is about 0.001 ingredients during preparation thereof, and on the stabiliza weight% to about 25 weight%, based on the total weight of tion during Subsequent baking, handling and storage of the the composition. In an embodiment, the Surfactant actives are food products. Surfactants can be used to stabilize food prod present in an amount of from about 0.01 weight% to about 15 ucts such as butter, yogurt, cheese, ice cream and the like to weight%, based on the total weight of the composition. In yet keep the food products adequately dispersed and to control another embodiment, the Surfactant actives are present in an rheology. amount of from about 0.1 weight % to about 10 weight %, 0187. The extracts, e.g., individual molecular composi based on the total weight of the composition. tions, according to this disclosure may be used as Surfactants 0181 Agrochemicals such as pesticides, animal food for food products. The Surfactant actives, e.g., Bacopa plant additives, veterinary drugs, and related compounds, have extract, Centella plant extract, and/or mixture thereof, are become integral to the production of large-scale agriculture. present in the food products in an amount effective for impart Agrochemicals deal with all aspects of pesticide and herbi ing the desired surfactant effect in the desired time. A suitable cide delivery systems, including emulsifiable concentrates, effective amount of the surfactant actives is about 0.001 water dispersible granules, wettable powders, Suspo-emul weight% to about 25 weight%, based on the total weight of sions, micro-emulsions, capsule Suspensions, and low the composition. In an embodiment, the Surfactant actives are aquatic toxicity adjuvants. present in an amount of from about 0.01 weight% to about 15 0182. The extracts according to this disclosure may be weight%, based on the total weight of the composition. In yet used as Surfactants in agrochemical formulations. The Surfac another embodiment, the Surfactant actives are present in an tant actives, e.g., Bacopa plant extract, Centella plant extract, amount of from about 0.1 weight % to about 10 weight %, and/or mixture thereof, are present in the agrochemical for based on the total weight of the composition. Mixtures of mulations in an amount effective for imparting the desired extracts may be particularly useful in this application. surfactant effect in the desired time. A suitable effective 0188 The topical application of liquid compositions, e.g., amount of the surfactant actives is about 0.001 weight% to coating and printing ink compositions, to surfaces to effect a about 25 weight%, based on the total weight of the compo desired change involve processes of controlling wetting, sition. In an embodiment, the Surfactant actives are present in spreading, flow, leveling, foaming, detergency, and the like. an amount of from about 0.01 weight% to about 15 weight%, Surfactants can be used to obtain desired properties. based on the total weight of the composition. In yet another 0189 The extracts according to this disclosure may be embodiment, the Surfactant actives are present in an amount used as Surfactants for coating and printing ink compositions. of from about 0.1 weight% to about 10 weight%, based on The Surfactant actives, e.g., Bacopa plant extract, Centella the total weight of the composition. plant extract, and/or mixture thereof, are present in the coat US 2011/0236324 A1 Sep. 29, 2011 ing and printing ink compositions in an amount effective for lights, but also can Scavenge free radicals efficiently. The free imparting the desired surfactant effect in the desired time. A radical scavenging capacity of Bacopa monniera plant extract suitable effective amount of the surfactant actives is about was evaluated using electron spin resonance (ESR) tech 0.001 weight % to about 25 weight %, based on the total niques. ESR is considered to be the least ambiguous method weight of the composition. In an embodiment, the Surfactant for the detection of free radicals. Free radical scavenging actives are present in an amount of from about 0.01 weight% activity results are illustrated in FIG. 2. to about 15 weight%, based on the total weight of the com 0197) The nitroxide free radical tetramethylpiperidinyl-1- position. In yet another embodiment, the Surfactant actives oxy (Tempo) was used as a stable free radical. An alcohol are present in an amount of from about 0.1 weight% to about Solution of Tempo was mixed with Bacopa monniera plant 10 weight%, based on the total weight of the composition. extract for 2 minutes followed by ESR measurements. Model 0190. In addition to surfactant properties, the extracts of ESR spectra of Tempo in the absence and the presence of this disclosure may impart other desired properties Such as Bacopa monniera plant extract are illustrated in FIG. 2. 100 anti-bacterial and anti-fungal properties to the dishwashing ug of Bacopa monniera plant extract resulted in almost dis detergent. appearance of the Tempo free radical peaks. 0191 The extracts according to this disclosure may be 0198 FIG. 2 shows the free radical scavenging activity of used as additives in fabric and fiber care compositions to Bacopa monniera plant extract determined by ESR, in par impart desired properties such as, for example, UV protection ticular, that 100 lug of plant extract can scavenge 1 mg of and fabric softening. The UV protection/fabric softening Tempo stable free radicals completely. actives, e.g., Bacopa plant extract, Centella plant extract, and/or mixture thereof, are present in the compositions in an Example 3 amount effective for imparting the desired UV protection/ 0199 The free radical scavenging capacity of the Bacopa fabric softening effect in the desired time. A suitable effective monniera extract product was evaluated using spectrophoto amount of the UV protection/fabric softening actives is about metric and electron spin resonance (ESR) techniques. ESR is 0.001 weight % to about 25 weight %, based on the total considered to be the least ambiguous method for the detection weight of the composition. In an embodiment, the UV pro of free radicals. tection/fabric softening actives are present in an amount of 0200 2.2-Diphenyl-1-picrylhydrazyl (DPPH) was used as from about 0.01 weight% to about 15 weight%, based on the a stable free radical. An alcohol solution of DPPH was mixed total weight of the composition. In yet another embodiment, with 100 g of a Bacopa monniera extract product for 2 the UV protection/fabric softening actives are present in an minutes and then ESR measurements were conducted. Quer amount of from about 0.1 weight % to about 10 weight %, cetine was used as a positive control for Scavenging the free based on the total weight of the composition. radicals. A slight change in peak height was observed in the 0192 Various modifications and variations of this disclo presence of 100 pg of quercetine, while 100 ug of the Bacopa sure will be obvious to a worker skilled in the art and it is to monniera extract product resulted in the disappearance of free be understood that such modifications and variations are to be radical peak. included within the purview of this application and the spirit What is claimed is: and scope of the claims. 1. A cosmeceutically active extract selected from the group Example 1 consisting of a Bacopa plant extract, a Centella plant extract, 0193 The active soluble components from Bacopa mon and a mixture thereof. niera (stems, leaves and roots) were air-dried and ground to 2. A cosmeceutically active extract selected from the group form powder. 100 grams of the powder was extracted three consisting of a Sunless tanning active extract of a Bacopa times using water alone, ethanol alone, methanol and differ plant, a Centella plant, or a mixture thereof a Sunscreen ent ratio of water:methanol and water:ethanol solution at a active extract of a Bacopa plant, a Centella plant, or a mixture temperature of 20-90° C. for a period of 24 hours. The super thereof; an ultraviolet radiation protective extract of a Bacopa natant was separated from the solid residue by filtration. The plant, a Centella plant, or a mixture thereof an anti-aging solvent in the Supernatant was removed by evaporation at 50° active extract of a Bacopa plant, a Centella plant, or a mixture C. under reduced pressure. The resulting Suspension was then thereof, an anti-wrinkle active extract of a Bacopa plant, a lyophilized to yield powder using the extract. The lyophilized Centella plant, or a mixture thereof; a moisturizing active powder was refrigerated and used for all the studies. extract of a Bacopa plant, a Centella plant, or a mixture 0.194. A known amount of the freeze dried sample was thereof: a skin soothing active extract of a Bacopa plant, a dissolved in triple distilled water and then absorbance of the Centella plant, or a mixture thereof a skin/hair softening Solution was measured as a function of wavelength at differ active extract of a Bacopa plant, a Centella plant, or a mixture ent concentrations and illustrated in FIGS. 1 and 2. The thereof: a skin/hair treatment active extract of a Bacopa plant, Bacopa monniera plant extract has the exceptional quality to a Centella plant, or a mixture thereof an anti-inflammatory absorb the ultraviolet (UV) light completely, for example, active extract of a Bacopa plant, a Centella plant, or a mixture between 190-400 nm. thereof: a cosmeceutical preservative active extract of a 0.195 FIG. 1 shows UV-visible spectra of Bacopa monni Bacopa plant, a Centella plant, or a mixture thereof a cos era plant extract at various different concentrations. It is meceutical stabilizer active extract of a Bacopa plant, a Cen evident from FIG. 1 that the Bacopa monniera extract has the tella plant, or a mixture thereof an antioxidant active extract capability to absorb light in the entire UV range, for example, ofa Bacopa plant, a Centella plant, or a mixture thereof; a free from 190-400 nm. radical inhibitive extract of a Bacopa plant, a Centella plant, or a mixture thereof; a cleansing active extract of a Bacopa Example 2 plant, a Centella plant, or a mixture thereof an anti-microbial 0196. It has also been demonstrated that these natural active extract of a Bacopa plant, a Centella plant, or a mixture Bacopa monniera extract products not only can absorb UV thereof anti-fungal active extract of a Bacopa plant, a Cen US 2011/0236324 A1 Sep. 29, 2011

tella plant, or a mixture thereof a hair coloring active extract nierin; said flavonoids are selected from the group consisting of a Bacopa plant, a Centella plant, or a mixture thereof, and ofluteolin and apigenin, said bacosides are selected from the an oral cleaning/deodoring active extract of a Bacopa plant, a group consisting of bacosides A, bacosides B, bacopaside II, Centella plant, or a mixture thereof. bacopaside I, bacopaside X, bacopaside N2, bacopaside N1, 3. The extract of claim 1 which comprises at least one bacopaside III, bacopaside IV, and bacopaside V: said component selected from the group consisting of alkaloids, bacopasaponins are selected from the group consisting of saponins, flavonoids, betulic acid, StigmaStarol, B-sitosterol, bacopasaponin C, bacopasaponin F, and bacopasaponin E: bacosides, bacopasaponins, triterpene acids, and triterpene said triterpene acids are selected from the group consisting of glycosides. asiatic acid, brahmic acid, isobrahmic acid, madecassic acid, 4. The extract of claim 3 wherein said alkanoids are and betulinic acid; and said triterpene glycosides are selected selected from the group consisting of brahmine and herpes from the group consisting of asiaticoside, madecassoside, tine, said Saponins are selected from the group consisting of brahmoside, and brahminoside. d-mannitol, hersaponin, acid A and monnierin; said fla 13. The cosmeceutical composition of claim 8 wherein said vonoids are selected from the group consisting of luteolin and Bacopa plant extract is obtained from any part of a Bacopa apigenin, said bacosides are selected from the group consist plant, and said Centella plant extract is obtained from any part ing of bacosides A, bacosides B, bacopaside II, bacopaside I. of a Centella plant. bacopaside X, bacopaside N2, bacopaside N1, bacopaside III, 14. The cosmeceutical composition of claim 8 wherein said bacopaside IV, and bacopaside V: said bacopasaponins are Bacopa plant extract, Centella plant extract, or mixture selected from the group consisting of bacopasaponin C, thereof, is about 0.001 weight percent to about 25 weight bacopasaponin F, and bacopasaponin E: said triterpene acids percent of the total weight of the cosmeceutical composition. are selected from the group consisting of asiatic acid, brahmic 15. The cosmeceutical composition of claim 8 wherein said acid, isobrahmic acid, madecassic acid, and betulinic acid; cosmeceutically acceptable carrier is selected from the group and said triterpene glycosides are selected from the group consisting of water, liquid or Solid emollients, solvents, consisting of asiaticoside, madecasso side, brahmoside, and humectants, thickeners, powders, and perfumes. brahminoside. 16. The cosmeceutical composition of claim 8 wherein said 5. The extract of claim 1 which is obtained using an extrac cosmeceutically acceptable carrier is about 0.001 weight per tion medium comprising at least one solvent selected from the cent to about 99.9 weight percent of the total weight of the group consisting of water, low molecular weight alcohols, cosmeceutical composition. esters, hydrocarbons, ketones, halogen-containing hydrocar 17. The cosmeceutical composition of claim 8 which is bons, and mixtures thereof. used in topical form. 6. The extract of claim 1 wherein the Bacopa plant is 18. The cosmeceutical composition of claim 17 in which selected from the group consisting of Bacopa australis, the topical form is selected from a solution, emulsion, serum, Bacopa Caroliniana, Bacopa crenata, Bacopa eisenii, skin and/or hair cleanser, body wash, body Scrub, bar soap, Bacopa madagascariensis, Bacopa monniera, Bacopa liquid Soap, shampoo, lather, deodorant, skin and/or hair care myriophylloides, Bacopa rotundifolia, and mixtures thereof. preparation, foam, mousse, cream, lotion, pomade, balm, and the Centella plant is selected from the group consisting of Stick, gel, pump spray, aerosol spray, and combinations Centella asiatica and Centella erecta, and mixtures thereof. thereof. 7. The extract of claim 1 wherein the Bacopa plant is 19. The cosmeceutical composition of claim 8 which is Bacopa monniera and the Centella plant is Centella asiatica. selected from a Sunless tanning composition, a Sunscreen 8. A cosmeceutical composition comprising, in an effective composition, an ultraviolet radiation protective composition, concentration, at least one of a Bacopa plant extract, a Cen an anti-aging composition, an anti-wrinkle composition, a tella plant extract, or a mixture thereof, and at least one moisturizer composition, askin Soothing composition, a skin/ cosmeceutically acceptable carrier. hair softening composition, a skin/hair treating composition, 9. The cosmeceutical composition of claim 8 wherein said an anti-inflammatory composition, a cosmeceutical preserva Bacopa plant extract is obtained from Bacopa australis, tive composition, a cosmeceutical stabilizer composition, an Bacopa Caroliniana, Bacopa crenata, Bacopa eisenii, antioxidant composition, a free radical inhibitive composi Bacopa madagascariensis, Bacopa monniera, Bacopa tion, a cleansing composition, an anti-microbial composition, myriophylloides, Bacopa rotundifolia, or mixtures thereof. an anti-fungal composition, a hair coloring composition, and and the Centella plant extract is obtained from Centella asi an oral cleaning/deodoring composition. atica, Centella erecta, or mixtures thereof. 20. A method of protecting or treating skin and/or hair of 10. The cosmeceutical composition of claim8 wherein said humans which comprises applying to the skin and/or hair a Bacopa plant extract is obtained from Bacopa monniera, and cosmeceutical composition comprising, in an effective con said Centella plant extract is obtained from Centella asiatica. centration, at least one of a Bacopa plant extract, a Centella 11. The cosmeceutical composition of claim8 wherein said plant extract, or a mixture thereof, and at least one cosmeceu Bacopa plant extract comprises at least one component tically acceptable carrier. selected from the group consisting of alkaloids, saponins, 21. The method of claim 20 wherein the cosmeceutical flavonoids, betulic acid, StigmaStarol, B-sitosterol, bacosides composition is selected from a Sunless tanning composition, and bacopasaponins; and said Centella plant extract com a Sunscreen composition, an ultraviolet radiation protective prises at least one component selected from the group con composition, an anti-aging composition, an anti-wrinkle sisting of triterpene acids and triterpene glycosides. composition, a moisturizer composition, a skin soothing 12. The cosmeceutical composition of claim 11 wherein composition, a skin/hair softening composition, a skin/hair said alkanoids are selected from the group consisting of brah treating composition, an anti-inflammatory composition, a mine and herpestine; said saponins are selected from the cosmeceutical preservative composition, a cosmeceutical sta group consisting of d-mannitol, hersaponin, acid A and mon bilizer composition, an antioxidant composition, a free radi US 2011/0236324 A1 Sep. 29, 2011 cal inhibitive composition, a cleansing composition, an anti cariensis, Bacopa monniera, Bacopa myriophylloides, microbial composition, an anti-fungal composition, a hair Bacopa rotundifolia, and mixtures thereof, and the Centella coloring composition, and an oral cleaning/deodoring com plant extract is obtained from Centella asiatica and Centella position. erecta, and mixtures thereof. 22. An active extract selected from the group consisting of 28. The composition of claim 26 wherein said Bacopa a Bacopa plant extract, a Centella plant extract, and a mixture plant extract is obtained from Bacopa monniera, and the thereof. Centella plant extract is obtained from Centella asiatica. 29. The composition of claim 26 which is selected from a 23. An extract selected from the group consisting of a stabilizer composition, a surfactant composition, a preserva stabilizeractive extract of a Bacopa plant, a Centella plant, or tive composition, and a treatment composition. a mixture thereof a surfactant active extract a Bacopa plant, 30. The composition of claim 29 wherein the stabilizer a Centella plant, or a mixture thereof a preservative active composition is used in coatings, paints, polymers, plastics extract a Bacopa plant, a Centella plant, or a mixture thereof. and emulsions; the Surfactant composition is used in oil and a treatment active extract a Bacopa plant, a Centella recovery, soil cleaning, mineral separation, agrochemicals, plant, or a mixture thereof. detergents, food product preparation, coating and printing 24. The extract of claim 22 wherein the Bacopa plant is inks; the preservative composition is used in foods; and the selected from the group consisting of Bacopa australis, treatment composition is used in fabric and fiber care. Bacopa Caroliniana, Bacopa crenata, Bacopa eisenii, 31. A method comprising: (i) providing a substrate; (ii) Bacopa madagascariensis, Bacopa monniera, Bacopa providing a composition comprising, in an effective concen myriophylloides, Bacopa rotundifolia, and mixtures thereof. tration, at least one of a Bacopa plant extract, a Centella plant and the Centella plant is selected from the group consisting of extract, or a mixture thereof, and at least one cosmeceutically Centella asiatica and Centella erecta, and mixtures thereof. acceptable carrier; and (iii) contacting the Substrate with the 25. The extract of claim 22 wherein the Bacopa plant is composition. Bacopa monniera, and the Centella plant is Centella asiatica. 32. The method of claim 31 wherein the composition is 26. A composition comprising at least one of a Bacopa selected from a stabilizer composition, a surfactant composi plant extract, a Centella plant extract, or a mixture thereof. tion, a preservative composition, and a treatment 27. The composition of claim 26 wherein said Bacopa composition. plant extract is obtained from Bacopa australis, Bacopa caro liniana, Bacopa crenata, Bacopa eisenii, Bacopa madagas