Sebastian Wendeborn
LIST OF PUBLICATIONS
1. Molecular Cloning and Characterization of Antigen Associated with Early Stages of Melanoma Tumor Progression. Hak Hotta, Alonzo Ross, Kay Huebner, Masakaru Isobe, Sebastian Wendeborn, Moses V. Chao, Robert P. Ricciardi, Yoshihide Tsujimoto, Carlo M. Croce, Hilary Kroprowski Cancer Research 1988, 48, 2955-2962.
2. A New Class of DNA-Cleaving Molecules: pH-Dependent DNA Cleavage by Propargylic and Allenic Sulfones. K.C. Nicolaou, G. Skokotas, P. Maligres, G. Zuccarello, E.J. Schweiger, K. Toshima, S. Wendeborn Angew. Chem. Int. Ed. Eng. 1989, 28, 1272.
3. Synthesis of Dynemicin A Models. K.C. Nicolaou, C.-K. Hwang, A.L. Smith, S.V. Wendeborn J. Am. Chem. Soc. 1990, 112, 7416-7418.
4. Selectivity and Mechanism of Action of Novel DNA Cleaving Agents. K.C. Nicolaou, S.V. Wendeborn, P. Maligres, K. Isshiki, N. Zein, G. Ellestad Angew. Chem. Int. Ed. Eng. 1991, 30, 418-420.
5. Enediyne Systems Equipped with Acid-, Base- and Photo- Sensitive Triggering Devices. Simulation of the Dynemicin A Cascade. K.C. Nicolaou, W.M. Dai, S. Wendeborn, A.L. Smith, Y. Torisawa, P. Maligres and C.-K. Hwang Angew. Chem. Int. Ed. Eng. 1991, 30, 1032-1036.
6. Synthesis and Chemistry of Dynemicin A Models. K.C. Nicolaou, A.L. Smith, S.V. Wendeborn, C.-K. Hwang J. Am. Chem. Soc. 1991, 113, 3106-3114.
7. Cationization of Organometallo Carbony Compounds through Fast Ion Bombardment. G. Siuzdak, S. Wendeborn, K.C. Nicolaou Int. J. Mass.Spectrom. Ion. Proc., 1992, 112, 79-91.
8. Molecular Design and Chemical Synthesis of Potent Enediyne Warheads 1. Dynemicin Model Systems Equipped with N-Tethered Triggering Devices. K. C. Nicolaou, P. Maligres, T. Suzuki, S. V. Wendeborn, W.-M. Dai, R. Chadha J. Am. Chem. Soc. 1992, 114, 8890-8907.
9. Why Pentose- and Not Hexose-Nucleic Acids? Part VII. Pyranosyl-RNA („p-RNA“). Stefan Pitsch, Sebastian Wendeborn, Bernhard Jaun, Albert Eschenmoser Helv. Chim. Acta 1993, 76, 2161-2183.
10. Backbone Modifications in Oligonucleotides and Peptide-Nucleic Acid (PNA) Systems. A. De Mesmaeker, K.-H. Altmann, A. Waldner, S. Wendeborn Curr. Opin. Struct. Biol 1995, 5, 343-355.
11. Pyranosyl-RNA (p-RNA): Base-Pairing Selectivity and Potential to Replicate. S. Pitsch, R. Krishnamurthy, S. Wendeborn, A. Holzner, C. Lesueur, I. Schloenvogt, B. Jaun, A. Eschenmoser Helv. Chim. Acta. 1995 78, 1621-1635.
12. Replacement of the Phosphordiester Linkage in Oligonucleotides by a C=C Double Bond: Comparison of the cis and trans Isomers. S. Wendeborn, R.M. Wolf, A. De Mesmaeker Tetrahedron Lett. 1995 36, 6879-6882.
13. Replacement of the Phosphodiester Linkage in Oligonucleotides by an Acetylenic Bond: Comparison Between Carbon-, Sulfur-, and Oxygen-containing Analogs. S. Wendeborn, C. Jouanno, R.M. Wolf, A. De Mesmaeker Tetrahedron Lett., 1996, 37, 5511-5514.
14. Hydrophobic Effects in Duplexes with Modified Oligonucleotide Backbones and DNA. A. Waldner, A. De Mesmaeker, S. Wendeborn Bioorg. Med. Chem. Lett. 1996, 6, 2363-2366. Sebastian Wendeborn
15. Backbone Modifications for Antisense Oligonucleotides. A. De Mesmaeker, A. Waldner, S. Wendeborn, R.M. Wolf Pure Appl. Chem. 1997, 69, 437-440.
16. Replacement of the Phosphodiester Linkage in Oligonucleotides by More Rigide Groups: Structural Features from Force Field Calculations. R.M. Wolf, V. Fritsch, A. De Mesmaeker, J. Lebreton, A. Waldner, S. Wendeborn New J. Chem., 1997, 21, 61-72.
17. Replacement of the Phosphodiester Linkage in Oligonucleotides by an Amide: Effect of Backbone Length on Duplex Stability with RNA Complement. Alain De Mesmaeker, Chantal Jouanno, Romain M. Wolf and Sebastian Wendeborn Bioorg. Med. Chem. Lett. 1997, 7, 447-452.
18. Amide Backbone Modifications for Antisense Oligonucleotides Carrying Potential Intercalating Substituents: Influence on the Thermodynamic Stability of the Corresponding Duplexes with RNA- and DNA-Complements. Alain De Mesmaeker, Sebastian Wendeborn, Chantal Jouanno and Romain M. Wolf Bioorg. Chem. Lett. 1997, 7, 1869-1874.
19. Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplex Formed with their RNA and DNA Complements. Alain De Mesmaeker, Jacques Lebreton, Chantal Jouanno, Valérie Fritsch, Romain M. Wolf, Sebastian Wendeborn Synlett 1997, 1287-1290.
20. Design and Structure of Backbone modifications in Antisense Oligonucleotides. Romain Wolf, Alain De Mesmaeker, Adrian Waldner, Sebastian Wendeborn Book of abstracts, 213th ACS National Meeting, San Francisco, April 13-17, 1997.
21. Pd- Mediated C-C and C-S Bond Formation on Solid Support: A Scope and Limitations Study. Sebastian Wendeborn, Sabine Berteina, Wolfgang K.-D. Brill, Alain De Mesmaeker Synlett 1998, 671- 675.
22. Pd- Mediated C-C Bond Formation with Olefins and Acetylenes on Solid Support: A Scope and Limitations Study. Sabine Berteina, Sebastian Wendeborn, Wolfgang K.-D. Brill, Alain De Mesmaeker Synlett 1998, 676-678.
23. Polymer Bound 3,5.Cyclohexadiene-1,2-Diols as Core Structures for the Development of Small Molecule Libraries. Sebastian Wendeborn, Wolfgang K.-D. Brill, Alain De Mesmaeker Synlett 1998, 865-868.
24. Development of Chloromethylated SynPhase Crowns and their Use in Pd(0) Mediated Cross Coupling Reactions. Sebastian Wendeborn, Renaud Beaudegnies, Kiah H, Ang, N. Joe Maeji Combinatorial Chemsitry 1998, 89.
25. Solid Phase Synthesis of Levoglucosan Derivatives. Wolfgang K.-D. Brill, Alain De Mesmaeker, Sebastian Wendeborn Synlett 1998, 1085.
26. Radical and Palladium-Mediated Cyclizations of Ortho-Iodo Benzyl Enamines: Application to Solid Phase Synthesis. Sabine Berteina, Sebastian Wendeborn, Alain De Mesmaeker Synlett 1998, 1231.
27. Functionalization via Radical Cyclization of Cyclohexenediol Derivatives Bound to Polystyrene. Sabine Berteina, Alain De Mesmaeker, Sebastian Wendeborn Synlett 1999, 1121.
28. Solid Phase Synthesis of Substituted 2,3-Dihydroquinolin-4-ones. Sebastian Wendeborn Synlett 2000, 45.
Sebastian Wendeborn
29. Synthesis of Divers and Complex Molecules on Solid Phase. Sebastian Wendeborn, Alain De Mesmaeker, Wolfgang K.-D. Brill, Sabine Berteina Acc. Chem. Res. 2000, 33, 215.
30. A New Synthesis of Functionalized Imidazol-2-Ones. Sebastian Wendeborn, Tammo Winkler, Ingrid Foisy Tetrahedron Lett. 2000, 41, 6387.
31. Towards novel amide-modified oligonucleotides: asymmetric synthesis of 5’-(S)-methyl-3’- carboxymethylene-3’-deoxythymidine. Sebastian Wendeborn, Hannes Nussbaumer, Frédéric Robert, Mario Jörg, Johannes Paul Pachlatko Tetrahedron Lett. 2002, 43, 5461.
32. Enantioselective Synthesis of a Highly Preorganised 2’-Deoxy-Spiro-Nucleoside. Sebastian Wendeborn, Gregory Binot, Mafalda Nina, Tammo Winkler Synlett 2002, 1683.
33. New and efficient synthesis of 5’-amino-5’-(S)-methyl-2’,5’-dideoxynucleosides. Pierre M. J. Jung, Renaud Beaudegnies, Alain De Mesmaeker, Sebastian Wendeborn. Tetrahedron Lett. 2003, 44, 293.
34. Synthesis of Furazane Conjugated New Heterocycles. Renaud Beaudegnies, Sebastian Wendeborn Heterocycles 2003, 60, 2417.
35. Pentopyranosyl Oligonucleotide Systems. Stefan Pitsch, Sebastian Wendeborn, Ramanarayanan Krishnamurthy, Armin Holzer, Mark Minton, Martin Bolli, Christian Micula, Norbert Windhab, Roland Micura, Michael Stanek, Bernhard Jaun, Albert Eschenmoser Helv. Chim. Acta 2003, 86, 4270-4363.
36. Recognition of RNA by Amide Modified Backbone Nucleic Acids: Molecular Dynamics Simulations of DNA-RNA Hybrids in Aqueous Solution. Mafalda Nina, Raymonde Fonne-Pfister, Renaud Beaudegnies, Habiba Checkatt, Pierre Jung, Alain De Mesmaeker, Sebastian Wendeborn J. Am. Chem. Soc. 2005, 127, 6027
37. New Method Based on 1-(Trimethysilyl)alk-1-yne To Prepare 1,4-Skipped Diynes. Florian Montel, Renaud Beaudegnies, Jilali Kessabi, Benjamin Martin, Eric Muller, Sebastian Wendeborn, Pierre M.J. Jung Org. Lett. 2006, 8, 1905.
38. Copper-Free Synthesis of Skipped Diynes via Cross-Coupling Reactions of Alkynylalanes with Propargylic Electrophiles. Jilali Kessabi, Renaud Beaudegnies, Pierre M. J. Jung, Benjamin Martin, Florian Montel, and Sebastian Wendeborn Org. Lett. 2006, 8, 5629.
39. A convenient, High-Yielding Copper-Free Synthesis of Skipped 1,4-Diynes. Jilali Kessabi, Renaud Beaudegnies, Pierre M. J. Jung, Benjamin Martin, Florian Montel, and Sebastian Wendeborn Synthesis (Practical Synthetic Procedures) 2008, 4, 655.
40. Discovery and SAR of pinoxaden: a new broad spectrum, postemergence cereal herbicide. Muehlebach, Michel; Brunner, Hans-Georg; Cederbaum, Fredrik; Maetzke, Thomas; Mutti, Rene; Schnyder, Anita; Stoller, Andre; Wendeborn, Sebastian; Wenger, Jean; Boutsalis, Peter; Cornes, Derek; Friedmann, Adrian A.; Glock, Jutta; Hofer, Urs; Hole, Stephen; Nidermann, Thierry; Quadranti, Marco. Pesticide Chemistry 2007, 101-110.
41. Formal synthesis of leustroducsin B. Joelle Moise, Ravindra P Sonawane, Camilla Corsi, Sebastian V. Wendeborn, Stellios Arseniyadis, Janine Cossy Synlett 2008, 17, 2617.
42. A Convergent Approach toward the C1-C11 Subunit of Phoslactomycins and Formal Synthesis of Phoslactomycin B. Valerie Druais, Michael J. Hall, Camilla Corsi, Sebastian V. Wendeborn, Christophe Meyer, Janine Cossy Organic Letters 2009, 11, 935.
43. Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors - A review of the triketone chemistry story from a Syngenta perspective. Renaud Beaudegnies, Andrew J. F. Edmunds, Torquil E.M. Sebastian Wendeborn
Fraser, Roger G. Hall, Timothy R. Hawkes, Glynn Mitchell, Juergen Schaetzer, Sebastian Wendeborn, Jane Wibley, Bioorganic & Medicinal Chemistry 2009, 17, 4134.
44. Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 1: pyrido[2,3- b]pyrazines. Patrick J. Crowley, Clemens Lamberth, Urs Mueller, Sebastian Wendeborn, Kurt Nebel, John Williams, Olivia-A Sageot, Neil Carter, Tanya Mathie, Hans-Joachim Kempf, Jeremy Godwin, Peter Schneiter, Markus R. Dobler Pest Management Science 2010, 66, 178.
45. Niementowski-type synthesis of pyrido[3,2-e][1,2,4]triazines: potentaza-analogs of pyrido[2,3- b]pyrazine fungicides Patrick J. Crowley, Clemens Lamberth, Urs Muller, Sebastian Wendeborn, Olivia-A. Sageot ,John Williams a, Alexander Bartovicˇ Tetrahedron Lett. 2010, 51, 2652.
46. A convergent approach toward phoslactomycins and leustroducsins Valerie Druais, Michael J. Hall, Camilla Corsi, Sebastian Wendeborn, Christophe Meyer, Janine Cossy Tetrahedron 2010, 66, 6358.
47. Efficient synthesis of novel bridgehead-substituted bicyclo[3.2.1]octane-2,4-diones Sebastian Wendeborn, Hannes Nussbaumer; Juergen Schaetzer, Tammo Winkler Synlett 2010, 13, 1966.
48. Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part 2: Chemistry and biology of the cereal herbicide pinoxaden Michel Muehlebach, Fredrik Cederbaum, Derek Cornes, Adrian A. Friedmann, Jutta Glock, Gavin Hall, Adriano F. Indolese, Daniel P. Kloer, Gael Le Goupil, Thomas Maetzke, Hans Meier, Rudolf Schneider, Andre Stoller, Henry Szczepanski, Sebastian Wendeborn and Hans Juerg Widmer Pest Management Science 2011, 67, 1499.
49. Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines Clemens Lamberth, Stephan Trah, Sebastian Wendeborn, Raphael Dumeunier, Mikael Courbot, Jeremy Godwin, Peter Schneiter Bioorg. Med. Chem. 2012, 20, 2803.
50. Organocatalytic conversion of ribose and other protected carbohydrate derivatives into 2-deoxy- lactones Sebastian Wendeborn, Regis Mondiere, Isabelle Keller, Hannes Nussbaumer Synlett 2012, 23, 541.
51. Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 3: Imidazoles Clemens Lamberth, Raphael Dumeunier, Stephan Trah, Sebastian Wendeborn, Jeremy Godwin, Peter Schneiter, Andy Corran Bioorg. Med. Chem. 2013, 21, 127.
52. Chirality in agrochemicals (book chapter) Sebastian Wendeborn, Edouard Godineau, Regis Mondiere, Tomas Smejkal, Helmars Smits in Comprehensive Chirality Vol.1, pp 120-166 (Eds. Carreira, Erick M.; Yamamoto, Hisashi), Elsevier (Amsterdam), 2012.
53. Chemicals inducing seed germination and early seedling development. Emmanuelle Villedieu- Percheron, Mathilde Lachia, Pierre M. J. Jung, Claudio Screpanti, Raymonde Fonne-Pfister, Sebastian Wendeborn, Didier Zurwerra, Alain De Mesmaeker Chimia 2014, 68(9), 654.
54. Biological activity of Brassinosteroids - direct comparison of known and new analogs in Planta. Sebastian Wendeborn, Mathilde Lachia, Pierre M. J. Jung, Joerg Leipner, David Brocklehurst, Alain De Mesmaeker, Katharina Gaus, Regis Mondiere Helv. Chim. Acta 2017, 100, e1600305.
55. Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. Gonzalo Sáez-Calvo, Ashwani Sharma, Francisco de Asís Balaguer, Isabel Barasoain, Javier Rodríguez-Salarichs, Natacha Olieric, Hugo Muñoz-Hernández, Manuel Álvaro Berbís, Sebastian Wendeborn, Miguel Angel Peñalva, Ruth Matesanz, Ángeles Canales, Andrea Enrico Prota, Jesús Jímenez-Barbero, José Manuel Andreu, Clemens Lamberth, Michel Olivier Steinmetz, José Fernando Díaz Cell Chem. Bio. 2017, 24 (6), 737. Sebastian Wendeborn
56. Defining and exploiting hypersensitivity hotspots to facilitate abscisic acid receptor agonist optimization. Dezi lzinga, Erin Sternburg, Davide Sabbadin, Michael Bartsch, Sang-Youl Park, Aditya Vaidya, Assaf Mosquna, Amita Kaundal, Sebastian Wendeborn, Mathilde Lachia, Fedor Karginov, Sean Cutler ACS Chem. Biol. 2019, in press.
LECTURES
1. Multiparallel Synthesis for Library Generation. Sebastian Wendeborn (25 min. presentation) The 3rd International Conference on Microplate Technology (MipTec98), Basel, Switzerland, June 15-18, 1998.
2. Synthesis of Small and Complex Molecules on the Solid Phase. Sebastian Wendeborn. Lecture at the Scripps Research Institute, La Jolla, CA, February 7, 2000.
3. Examples of chemical research at Syngenta. Sebastian Wendeborn. Lecture at the Ecole Polytechnique, Palaiseau, France, 13.December 2002.
4. Sterol C(14) demethylase inhibitors as fungicides for use in crop protection. Sebastian Wendeborn. Lecture at the Swiss Chemical Society Fall Meeting, Zürich, 11. September, 2014.
5. Optimization of Manganese Coupling Reaction for Kilogram-scale Preparation of two Aryl-1,3-dione Building Blocks. Sebastian Wendeborn. Lecture at the ‘Emerging Trends in AgroScience Chemistry & Technology, Goa, India, 21-23 November, 2016.