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Stephen Mullin – Phd Thesis
Stephen Mullin – PhD thesis Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway Dr. Stephen Mullin 64,106 words 1 Stephen Mullin – PhD thesis For my wife Tanya and my darling daughter Jessica. This thesis took too many evenings and weekends which should have been spent with you both. Without your love and support it would never have been completed. 2 Stephen Mullin – PhD thesis Acknowledgements Above all I must express my gratitude to all the participants who took part in the studies that make up this thesis. Their commitment to research is humbling and inspiring. Moreover, I must also thanks the support of the Gaucher association (in particular Tanya Histed Collins, Jeremy Manuel and Dan Brown) and Parkinson’s UK. Their support was crucial to all of the work presented here. This thesis is a grounded on foundations of the previous work, good will and patience of numerous people. My mother and father who took on the uneviable task of proof reading it. Prof. Sandip Patel, Dr. Bethan Kilpatrick and Dr. Lizzie Yates took a neophyte and taught him, in spite of his medic tendencies, to carry out single cell imaging. Dr. Joana Magalhaes and Dr. Ania Migdalska showed considerable restraint in showing me how breed and harvest mice primary cultures. Dr. Michelle Beavan and Dr. Alistair Mcneil passed on a cohort of patients which most PhD students would be the envy of most PhD students. The efforts of Dr. Marco Toffoli and Dr. Micol Avenali were vital to the cohort study. Jonathan Bestwick tolerated my very tentative and unprepared immersion into the world of repeated measures statistics. -
Eros, Storge, Phileo, and Agape
Eros, Storge, Phileo, and Agape INTRODUCTION II. Storge Love is ambiguous in the English language. A. This is natural affection—family, kin, the There is “Strawberry Shortcake Love.” We love humblest of loves. We love each other simply cats, dogs, and ice cream. This is trite and with- because we are of the family. B. It is negative in Romans 1:31 and 2 Timothy out depth or permanence. There is “Aunt Minnie 3:3, used regarding homosexuals. Love” which is reserved for “special” people C. It is used in withdrawal in 2 Timothy 3:14, 15. who are sweet and lovable. Sometimes it is con- Withdrawal is not excommunication, put- descending. There is “Bowling Team Love” for ting one out of the church. It is what it says, “buddies” in a reciprocal way. Moderns do not withdrawal of fellowship. zero in on “Tough Love.” So there is a Greek word study. However, the III. Phileo Bible is not learned in a seminary; it is learned A. This is tender affection and brotherly love. out on the street with people in local work. (Philadelphia is the city of “brotherly love.”) Footnotes will not preach. Also, the Bible must B. However, sometimes we make too clear a not be reduced to word studies. You can get so distinction between phileo and agape. Be care- ful. There are surprises. Read Titus 2:3, 4; far out on a limb looking at a leaf you forget the Romans 12:9, 10; 1 Corinthians 16:22; He- tree. Word studies can be helpful, but they can brews 13:1; John 16:27; and 1 Peter 1:22. -
MISSISSIPPI LEGISLATURE REGULAR SESSION 2020 By
MISSISSIPPI LEGISLATURE REGULAR SESSION 2020 By: Senator(s) Simmons (12th), Norwood To: Rules SENATE RESOLUTION NO. 18 1 A RESOLUTION COMMENDING THE LIFE AND EXTENDING THE 2 CONDOLENCES OF THE MISSISSIPPI SENATE TO THE BEREAVED FAMILY OF 3 RESPECTED GREENVILLE CITIZEN AND DEMOCRATIC PARTY ACTIVIST RUTHIE 4 MAE RANSOM MORRIS. 5 WHEREAS, it is with sadness that we learned of the passing of 6 respected Mississippi Delta Citizen and Democratic Party Activist 7 Mrs. Ruthie Mae Ransom Morris; and 8 WHEREAS, Ruthie Mae Ransom Morris was born on October 24, 9 1942, in Leland, Mississippi, to Henry Parker Ransom, Sr., and 10 Blanche Johnson Ransom. She was the sixth of their ten children; 11 and 12 WHEREAS, Ruthie accepted Christ at an early age and was 13 baptized under the leadership of her uncle, Reverend Clarence 14 Johnson, who was the Founder and Senior Pastor of the Shady Grove 15 South Missionary Baptist Church in Greenville, Mississippi. 16 During her years at Shady Grove South Missionary Baptist Church, 17 Ruthie sang in the Senior Choir, typed and printed the Church 18 Bulletins, organized special events, and served as a trusted S. R. No. 18 *SS26/R991.1* ~ OFFICIAL ~ N1/2 20/SS26/R991.1 PAGE 1 (rdd\lr) 19 confidant and adviser to Reverend Clarence Johnson as well as to 20 his successor, Pastor Solomon B. Miller; and 21 WHEREAS, in 1997, Ruthie joined Agape Storge Christian Center 22 under the leadership of Dr. Thomas Paul Williams, who was a 23 lifelong family friend and former member of Shady Grove South 24 Missionary Baptist Church. -
Marriage in Christ Seminar Follow up Gatherings
Marriage in Christ Seminar Follow Up Gatherings 1 Contents Simple Instructions ......................................................................................................................... 3 Ordinary life in Christ: “It’s about the little things.” ...................................................................... 4 Protecting Unity by Negotiating Differences ................................................................................. 5 Thinking the Best: Part One ............................................................................................................ 7 Thinking the Best, Part Two ........................................................................................................... 8 The Story of Mother Gerda ............................................................................................................. 9 2 Simple Instructions Schedule about 1 – 1½ hours Gathering Opening prayer Food and conversation o Simple, e.g., potluck, dessert and coffee, wine and cheese, simple brunch, etc. o Sharing about how things have gone for the past several weeks. Share bright spots Highlights of the last week or two Changes that have occurred over time Break into discussion groups o Read the discussion topic (topics can be found on the alumni page of the website) o Discuss the questions Get back together o When do we want to meet next? o Agree to keep praying, talking and acting in your marriages Final Prayer 3 Ordinary life in Christ: “It’s about the little things.” As God's chosen ones, -
The Four Kinds of Love Activity Instructions
The Four Kinds of Love Activity Instructions Activity 1 Preparation: Cut up the texts on each of the four kinds of love Photocopy them onto different colour paper Set Up & Instructions Put the students in groups of 5 or 6 Tell the students their aim is to make notes on their table for each kind of love, using the information on the texts. Explain that the sub-box under each table category is for writing in examples of that kind of love. The students have 4 minutes per text, then shout “swap”: the students must put their text down and pick up another one. After 16 mins, give the students a few additional minutes to check their info with their partners, and complete anything missing. Feedback the answers. Activity 2 Summing Activity Explain how the love of a parent for their child can consist of all four kinds of love. Activity 3/ Plenary Nominate students from the class to choose a letter from the alphabet, name an adjective starting with that letter that would describe one kind of love. Encourage the students to explain their choice. Eg R - Romantic, C - caring Sacred Heart High School/mrumian 2009 The Four Kinds of Love Storge , or “affection” can be shown to people of objects. Towards people, storge is being fond of someone because we like and have got used to having them around. Eg a family member, or neighbour we have grown up with. Towards objects, storge is the loving satisfaction of having a good meal, or a fit and healthy body. -
Plutarch on the Role of Eros in a Marriage
1 2 3 4 Plutarch on the Role of Eros in a Marriage 5 6 Jeffrey Beneker 7 8 Plutarch’s thinking on marital relationships has attracted a significant amount 9 of interest in recent years and has been approached from a variety of 10 perspectives. Some scholars have studied the societal aspect of marriage in 11 Plutarch’s works, raising questions about the role of women in the household, 12 in the community, and especially in their interactions with men, and therefore 13 they have tended to address larger social issues, such as gender, sexuality, and 14 equality.1 Others have taken a philosophical tack and have examined Plutarch’s 15 writing, especially as it concerns the nature and value of marriage, in terms of 16 the broader philosophical traditions to which it is related.2 However, my focus 17 in this paper is much more narrow. I intend to explore one particular 18 component of the marital relationship itself: the erotic connection that exists, 19 or might exist, between a husband and wife. Looking first to the Moralia and 20 the dialogue Amatorius, I will argue that Plutarch describes the eros shared 21 between a married couple as an essential prerequisite for the development of 22 philia and virtue. Then, turning to the Lives, I will demonstrate how the ideas 23 found in the Amatorius are fundamental to Plutarch’s representation of 24 marriage in the biographies of Brutus and Pompey. 25 In the Amatorius, Plutarch, who is himself the principal speaker, touches on 26 a variety of topics related to eros, but the discussion itself is motivated by a 27 single event: the wealthy widow Ismenodora has expressed her desire to marry 28 the ephebe Bacchon, who comes from a family of lower social standing. -
February 17, 2019 More Love: Eros Proverbs 30:18-19 There Are Three
February 17, 2019 More Love: Eros Proverbs 30:18-19 There are three things that amaze me—no, four things that I don't understand: how an eagle glides through the sky, how a snake slithers on a rock, how a ship navigates the ocean, how a man loves a woman. Song of Solomon 8:6-7 Set me as a seal upon your heart, as a seal upon your arm; for love is strong as death, passion fierce as the grave. Its flashes are flashes of fire, a raging flame. Many waters cannot quench love, neither can floods drown it. If one offered for love all the wealth of his house, it would be utterly scorned. SERMON - More Love: Eros “All You Need is Love”, “What the World Needs Now is Love”, “Looking for Love in All the Wrong Places” These are all songs that at one time or another were popular best sellers. “Can You Feel the Love Tonight?” by Elton John is considered by some, the greatest love song of all-time. It staggers the mind to think of how many love songs have been written throughout the ages! Love is one of those universals that binds people together from different cultures and races – for we all know love. Whether we’ve fallen in love ourselves, or not, we have – at one point or another – experienced the gift of love in our lives, no matter how big or small. As Christians, we know something about love too! We are called to love --- to love God, and to love our neighbor as ourselves. -
From Romantic Jealousy to Sympathetic Joy: Monogamy, Polyamory, and Beyond Jorge N
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by California Institute of Integral Studies libraries Digital Commons @ CIIS International Journal of Transpersonal Studies Advance Publication Archive 2019 From Romantic Jealousy to Sympathetic Joy: Monogamy, Polyamory, and Beyond Jorge N. Ferrer Follow this and additional works at: https://digitalcommons.ciis.edu/advance-archive Part of the Feminist, Gender, and Sexuality Studies Commons, Philosophy Commons, Religion Commons, and the Transpersonal Psychology Commons From Romantic Jealousy to Sympathetic Joy: Monogamy, Polyamory, and Beyond Jorge N. Ferrer. Cailornia Institute of Integral Studies San Francisco, CA, USA This paper explores how the extension of contemplative qualities to intimate relationships can transform human sexual/emotional responses and relationship choices. The paper reviews contemporary findings from the field of evolutionary psychology on the twin origins of jealousy and monogamy, argues for the possibility to transform jealousy into sympathetic joy (or compersion), addresses the common objections against polyamory (or nonmonogamy), and challenges the culturally prevalent belief that the only spiritually correct sexual options are either celibacy or (lifelong or serial) monogamy. To conclude, it is suggested that the cultivation of sympathetic joy in intimate bonds can pave the way to overcome the problematic dichotomy between monogamy and polyamory, grounding individuals in a radical openness to the dynamic unfolding of life -
What Is Science-Based Bioethics?
Science-based Bioethics Ch. 1 Introduction Loike & Fischbach Chapter One What is Science-based Bioethics? Introduction Each year, biotechnology bravely ventures into unexplored scientific territory. The year 2016 was no exception: The number of scientific breakthroughs that emerged during this year is overwhelming with gene editing (CRISPR) technologies, gene drives to eliminate harmful mosquitos, and synthetic DNA topping the list. As will be discussed in Chapter Eight, scientists have developed ingenious methods to edit the DNA code of the human genome in cells, embryos, and human beings. Equally astonishing are the reports of two new synthetic DNA bases that have been synthesized. Applying this synthetic biology technology, scientists have expanded the DNA code from 4 to 6 base pairs (Malyshev et al., 2014). Yet, the real dangers of gene editing, synthetic biology, and the creation of a synthetic human genome remain unknown, raising the question whether humankind is dramatically overstepping innate ethical boundaries. In May of 2016, a closed door meeting convened to discuss the issue of constructing an entire human genome in a cell line, a project prospectively titled ‘HGP-Write: Testing Large Synthetic Genomes in Cells’. As the New York Times reports, the meeting was invite-only and “The nearly 150 attendees were told not to contact the news media or to post on Twitter during the meeting.” In the past year, neuroscience research has led to countless innovations as well. Selected examples include: a) stem cell and genetic technologies to enhance the cognition and learning potential of mice, b) brain rejuvenation of older mice to their youthful plasticity with stem cell technologies, c) artificial intelligence in human-like robots (see https://www.youtube.com/watch?v=W0_DPi0PmF0 for a dramatic video about human-like robots), and d) genetically modified bacteria that can function as biological circuits. -
Beyond Eros: Friendship in the Phaedrus
DRAFT Beyond eros: Friendship in the Phaedrus Plato is often held to be the first great theoriser of love in the Western tradition, and yet his account has been taken to be a resounding failure by many, if not most, modern scholars working on this topic. Criticisms have been articulated forcefully by Vlastos whose seminal paper „The Individual as an Object of love‟ charged Plato with „cold-hearted egoism‟; his account, he argued, disdained persons in favour of abstract, conceptual, objects – the so-called Platonic Forms, and advocates a „spiritualized egocentrism…scarcely aware of kindness, tenderness, compassion, concern for the freedom, respect for the integrity of the beloved, as essential ingredients of the highest type of interpersonal love‟ (Vlastos (1981/2000: 642)). The evidence is roughly as follows. In the Symposium Plato argues that the highest form of eros, roughly, „passionate desire‟ is love for Forms, and beautiful bodies and souls are to be used „as steps‟ towards this end. The Lysis appears to be the only exploration of friendship (philia), and this is an inconclusive work. At best, it is held, the lack of an account of love and friendship for persons compares unfavourably with Aristotle‟s detailed account of philia, which occupies two books of his Ethics and is, arguably, central to his account of human flourishing; at worst, this omission supports the view of Plato as „a cold-hearted egoist‟ who disdained persons in favour of abstract objects. If Plato thought philosophy could answer the question how should one live, in one crucial area of his thought the life worth living is not, apparently, a life worth choosing; as Aristotle made explicit, no one would choose to live without friends. -
The Four Loves Storge – Natural Affection Phileo – Friendship Eros
Revolution Part 4 - John Breland!South Coast Sermon Notes (1 Corinthians 14:1 LB) “Make love your greatest aim…” The Greatest Love of All (John 13:35) “By this all men will know that you are my 1. Love God fully. disciples, if you love one another.” (1 John 4:7-8) “Dear friends, let us love one another, for (1 John 3:18) “Dear children, let us not love with words or love comes from God. Everyone who loves has been born of God and knows God. Whoever does not love does not know tongue but with actions and in truth.” God, because God is love.” The Four Loves (1 John 4:19) “We love because he first loved us.” Storge – natural affection 2. Accept others unconditionally. (Romans 15:7) “Accept one another, then, just as Christ (Romans 12:10) “Be devoted to one another in brotherly accepted you, in order to bring praise to God.” love. Honor one another above yourselves.” 3. Commit yourself personally. Phileo – friendship (Romans 12:10) “Be devoted to one another in brotherly (Matthew 10:37) “Anyone who loves his father or mother love.” more than me is not worthy of me; anyone who loves his son or daughter more than me is not worthy of me.” 4. Encourage others continually. Eros – physical attraction (1 Thessalonians 5:11) “Therefore encourage one another and build each other up, just as in fact you are doing.” Agape – unconditional love (1 Corinthians 13:7 LB) “If you love someone…you will always believe in him, and always expect the best of him…” (John 15:13) “Greater love has no one than this, that he lay down his life for his friends.” 5. -
Graduate Catalog 2012-2014
Where Knowledge and Character Matter Graduate Catalog 2012-2014 2 ALCORN STATE UNIVERSITY The Alcorn State University 2012-2014 Graduate Studies Catalog is published by Alcorn State University, 1000 ASU Drive, Alcorn State, Mississippi 39096-7500 Publication Editors: Julia Odom, Donzell Lee Publisher: Academic Affairs Office, Alcorn State University Cover Illustration: Oakland Memorial Chapel Cover Design: © 2012 Alcorn State University. All rights reserved. This catalog is not an unchangeable contract but, instead, an announcement of present policies only. Implicit in each student’s matriculation with the university `is an agreement to comply with university rules and regulations that the university may modify to exercise properly its educational responsibility. Any updates following this publication will be posted on the website under a separate cover. The university complies with all laws regarding affirmative action and equal opportunity in all its activities and programs and does not discriminate against anyone on the basis of age, creed, color, national origin, race, religion, gender, handicap, or military status. ALCORN STATE UNIVERSITY 3 "Campus of Excellence" GRADUATE CATALOG 2012-2014 4 ALCORN STATE UNIVERSITY TABLE OF CONTENTS Board of Trustees .............................................................................................................. 10 Academic Administration ................................................................................................. 16 Office of Graduate Studies ...............................................................................................