Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_009720545Cyc: Gimesia maris DSM 8797 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a dicarboxylate phosphate 3-O-L-lysyl-1-O- an amino acid an amino an amino hemin arsenite phosphatidylglycerol acid acid phosphate phosphate predicted ABC HemP ArsB MprF RS19155 RS07765 RS04795 RS15760 RS26770 transporter of phosphate 3-O-L-lysyl-1-O- phosphatidylglycerol hemin arsenite an amino an amino an amino phosphate phosphate acid acid acid phosphate a dicarboxylate

Nucleoside and Nucleotide Degradation Polyprenyl Biosynthesis Aminoacyl-tRNA Charging glutaminyl-tRNA gln Metabolic Regulator Macromolecule Modification tRNA-uridine 2-thiolation Tetrapyrrole Biosynthesis di-trans,octa-cis UDP-N-acetyl- a nascent peptidoglycan a peptidoglycan UDP-N-acetyl-α-D- a 2'- a [bis(guanylyl an N-terminal- an N-terminal- a 6-(N-acetyl-α- a [protein]-L- a peptide with a [protein] biosynthesis via transamidation Biosynthesis and selenation (bacteria) purine nucleotides degradation II (aerobic) a [protein]- a DNA methyl (4S)-4-hydroxy-2- -undecaprenyl α γ γ muramoyl-L-alanyl- deoxyribonucleoside L-methionyl-L- L-methionyl-L- glutamate-O 5 carbonic acid di-trans,poly-cis purine ribonucleosides degradation phospho-N- -D-muramoyl- with (L-alanyl- -D- with (L-alanyl- -D- L-cysteine phosphotriester [DNA] molybdopterin) cys oxoheptanedioate D-glucosaminyl)- an N-terminal C-terminal glu a protein tetrapyrrole biosynthesis phosphate γ γ-D-glutamyl-meso- 5'-triphosphate cysteinyl-[protein] threonyl-[protein] -methyl-ester -undecaprenyl trehalose acetylmuramoyl- L-alanyl- -D- glutamyl-meso-2,6- glutamyl-meso-2,6- D-alanyl-D-alanine cofactor 1-phosphatidyl- L-methionine L-glutamate ATP- glu phosphate biosynthesis I (from glutamate) cys glutamyl-meso-2,6- diaminopimeloyl- diaminopimeloyl-D- 2,6-diaminopimelate chaperone]- 1D-myo-inositol biosynthesis V AMP pentapeptide- methylated-DNA-- 2,4-dihydroxyhept- carbonic dependent diaminopimeloyl- D-alanyl-D-alanine) alanine) tetrapeptide RNA-directed L-cysteine IPP (2E,6E)-farnesyl cysteine adenosine transferase: mraY [protein]-cysteine S- type I methionyl type I methionyl 2-ene-1,7-dioic chemotaxis type I methionyl anhydrase: 30S protease diphosphate a glycogen glu D-alanyl-D-alanine pentapeptide UDP-N- DNA polymerase: aminopeptidase: aminopeptidase: aminopeptidase: subunit desulfurase: 5'/3'- methyltransferase: acid aldolase: GlcNAc-PI de- response F1729_RS10225 ribosomal glycogen glutamate-- adenosine acetylmuramoyl- F1729_RS14790 cysteine map map N-acetylase: regulator protein- map protein HslV: hslV debranching tRNA ligase: F1729_RS27890 nucleotidase F1729_RS25790 F1729_RS25320 carbonic gln an L-glutamyl- isoprenyl deaminase: penicillin-binding tripeptide--D- RNA-directed desulfurase: type I methionyl type I methionyl F1729_RS12120 glutamate type I methionyl S6--L- a peptide protein F1729_RS24370 cysteine SurE: surE IMP methylated-DNA-- 2,4-dihydroxyhept- anhydrase: Gln transferase: an L-glutamyl- F1729_RS07620 protein 2: alanyl-D- alanine DNA polymerase: sufS aminopeptidase: aminopeptidase: methylesterase: aminopeptidase: glutamate [tRNA ] desulfurase: [protein]-cysteine S- 2-ene-1,7-dioic GlcNAc-PI de- F1729_RS10625 Asp-tRNA(Asn) F1729_RS06195 GlgX: glgX Glu F1729_RS18880 ligase: murF F1729_RS23905 [tRNA ] sufS adenosine GMP undecaprenyldiphospho- UMP cysteine map map N-acetylase: cheB map ligase: rimK /Glu-tRNA(Gln) Asp-tRNA(Asn) glycogen- IMP methyltransferase: acid aldolase: an [L-cysteine xanthosine adenosine inosine guanosine N-acetylmuramoyl-L- desulfurase: F1729_RS14635 chemotaxis amidotransferase: /Glu-tRNA(Gln) di-trans,octa-cis debranching glutamyl-tRNA dehydrogenase: γ F1729_RS03650 F1729_RS07110 desulfurase]-S- adenosine 5'/3'- alanyl- -D-glutamyl-meso a nascent peptidoglycan UDP-N-acetyl-α-D- F1729_RS27890 response CO H O a [protein] C- amidotransferase: -undecaprenyl reductase: guaB an N-terminal L- an N-terminal L- 2 2 gatC gatA gatB protein: sulfanyl-L-cysteine -2,6-diaminopimeloyl- with D,D cross-links D-ala muramoyl-L-alanyl- [DNA] α terminal α-L- gatC gatA gatB diphosphate F1729_RS18925 deaminase: nucleotidase met cysteinyl-[protein] met threonyl-[protein] 6-( -D- regulator protein- met a peptide [+ 8 isozymes] F1729_RS20995 purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside D-alanyl-D-alanine (meso-diaminopimelate γ-D-glutamyl-meso- a [protein]-S- succinate acetate glutamate-α- a 5-phosphooxy- undecaprenyl- (S)-4-amino-5- F1729_RS07620 SurE: surE [DNA] a [bis(guanylyl pyruvate glucosaminyl)- glutamate a maltodextrin XMP phosphorylase: phosphorylase: phosphorylase: phosphorylase: containing) 2,6-diaminopimeloyl- methyl-L-cysteine semialdehyde L-glutamate ammonium L-glutamyl- diphosphate oxopentanoate ala molybdopterin) 1-phosphatidyl- methylesterase: [tRNA Gln ] F1729_RS20760 F1729_RS20760 F1729_RS20760 F1729_RS20760 D-alanyl-D-alanine cofactor 1D-myo-inositol cheB phosphatase: glutamate-1- a [TusA sulfur- inosine guanosine 5'/3'- F1729_RS11510 carrier protein]-S- chaperone]-S- semialdehyde nucleotidase α Asp-tRNA(Asn) di-trans,octa-cis sulfanyl-L-cysteine -D-ribose- sulfanyl-L-cysteine a maltooligosyl- 2,1- purine-nucleoside purine-nucleoside SurE: surE a [protein]-α- /Glu-tRNA(Gln) -undecaprenyl phosphorylase: phosphorylase: 1-phosphate MeOH trehalose aminomutase: thymine degradation L-glutamate amidotransferase: phosphate F1729_RS20760 F1729_RS20760 gatC gatA gatB malto- hemL xanthosine a [TusD sulfur- oligosyltrehalose thymine UDP-N-acetyl- 5-deoxy-α- 5-aminolevulinate carrier protein]-S- hypoxanthine guanine D-ribose 5- undecaprenyldiphospho- quinoxaline-2- a carboxy- sn-glycero-3- 3-benzyl-3,6 - UDP-N-acetyl- phosphoenol a [protein]-L- an N-terminal- α H O D-glycero-β-D- acetylxylan sec an L-glutaminyl- trehalohydrolase: -D-glucosamine N-acetylmuramoyl-L- aryl-carrier protein adenylated- cys diphosphate 2 phospho-N- bis(cysteinylglycine) α-D-muramoyl- D-glt β L-methionyl-L- ser a tRNA D-ribose 1- sulfanyl-L-cysteine purine-nucleoside phosphate carboxyl adenylate ATP dGDP pyruvate -isoaspartate ATP roseoflavin Gln treZ γ manno-heptose protein-L- phosphate [tRNA ] porphobilinogen 5,6-dihydrothymine alanyl- -D-glutamyl-meso [ThiS sulfur- (arachidonoyl) - 6-(hydroxymethyl) L-alanine valyl-[protein] 5'-phosphate S-methyl-5- phosphorylase: 1-phosphate isoaspartate(D- α,α-trehalose synthase: hemB -2,6-diaminopimeloyl- carrier protein] ethanolamine -diketopiperazine acetylxylan thioribose-1- F1729_RS20760 hydantoinase: aspartate) O- D-alanyl-D-alanine acyl carrier RdgB/HAM1 family UDP-N- type I methionyl esterase: serine- phosphate tRNA charging a [TusE sulfur F1729_RS23305 methyltransferase: porphobilinogen protein: cysteine non-canonical glycerophosphodiester membrane bifunctional heptose acetylmuramoyl- pyruvate aminopeptidase: F1729_RS18715 bifunctional -tRNA isomerase: 34 carrier protein]-S undecaprenyldiphospho- F1729_RS10035 a uridine in tRNA xanthine 3-(carbamoylamino)- F1729_RS10310 desulfurase: purine NTP phosphodiesterase: dipeptidase: 7-phosphate L-alanine-- kinase: pyk map riboflavin kinase/ ligase: 5-deoxy-D-mtnA hydroxymethylbilane -sulfanylcysteine muramoylpentapeptide beta-N- pyrophosphatase: acetylxylan FAD synthetase: phe a tRNA Phe ser a tRNA ser arg a tRNA Arg a tRNA Ala ala tRNA asp asp 2-methylpropanoate [+ 3 isozymes] sufS F1729_RS06585 F1729_RS09585 kinase/heptose D-glutamate protein-L- type I methionyl serS ribulose 1- elongator synthase: hemC acetylglucosaminyltransferase: rdgB esterase: F1729_RS17510 asn tRNA Asn met initiator tRNA Met met thr a tRNA Thr trp a tRNA Trp his a tRNA His gly a tRNA Gly val a tRNA Val pro a tRNA Pro cys a tRNA Cys glu a tRNA glu tyr a tRNA Tyr leu a tRNA Leu lys a tRNA Lys 1-phosphate ligase: murD isoaspartate(D- phosphate Met tRNA 2- murG cysteine [+ 2 isozymes] aminopeptidase: F1729_RS04780 tRNA [+ 2 isozymes] adenyltransferase: aspartate) O- preuroporphyrinogen thiouridine(34) a quinoxaline-2- desulfurase: 3-benzyl-3,6 - pyruvate map Gln Ile an L-seryl- phenylalanine- serine- arginine- alanine- aspartate- gln a tRNA ile a tRNA bis(cysteinyl)- 6- gly F1729_RS26090 dGTP methyltransferase: roseoflavin synthase lipid II (meso UDP carboxyl-[aryl- F1729_RS27890 UDP-N-acetyl- sec -tRNA ligase: asparagine- methionine- methionine- -tRNA -tRNA threonine-- tryptophan- histidine- glycine-- valine-- proline-- -tRNA cysteine-- glutamate-- tyrosine-- leucine-- lysine- -tRNA urate (R)-3-amino-2- AMP sn-glycerol F1729_RS29375 xylan adenine [tRNA ] uroporphyrinogen- MnmA: mnmA diaminopimelate containing) carrier protein] anandamide (hydroxymethyl) α-D-muramoyl-L- a protein L-β- acetate F1729_RS21495 -tRNA -tRNA -tRNA ligase: ligase: tRNA ligase: -tRNA -tRNA tRNA ligase: tRNA ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA ligase: methylpropanoate H + 3-phosphate β an N-terminal dinucleotide III synthase: a thiocarboxylated- phosphate -diketopiperazine ADP-D-glycero- - alanyl-D-glutamate isoaspartate met pheS ligase: asnS ligase: metG ligase: metG serS argS F1729_RS08210 ligase: trpS ligase: hisS F1729_RS18125 F1729_RS19040 F1729_RS23065 alaS F1729_RS24250 F1729_RS24370 F1729_RS26610 F1729_RS27325 ligase: lysS aspS L-valyl-[protein] H + RS12585 H + F1729_RS17660 a 2-thiouridine 34 purine deoxyribonucleosides degradation I D-manno-heptose α AMP ala [ThiS sulfur- -methyl ester an L-methionyl- uroporphyrinogen-III in tRNA carrier protein] an L-phenylalanyl- an L-asparaginyl- an L-methionyl- an L-seryl- an L-arginyl- an L-threonyl- an L-tryptophanyl- an L-histidyl- an L-valyl- an L-prolyl- an L-alanyl- an L-cysteinyl- an L-glutamyl- an L-tyrosyl- an L-leucyl- an L-lysyl- an L-aspartyl- an L-glutaminyl- an L-isoleucyl- pyrimidine deoxyribonucleotides [elongator a glycyl-[tRNA Gly ] tRNA uridine-5- adenosine deaminase: [tRNA Phe ] [tRNA Asn ] [initiator tRNA Met ] [tRNA ser ] [tRNA Arg ] [tRNA Thr ] [tRNA Trp ] [tRNA His ] [tRNA Val ] [tRNA Pro ] [tRNA Ala ] [tRNA Cys ] [tRNA Glu ] [tRNA Tyr ] [tRNA Leu ] [tRNA Lys ] [tRNA asp ] [tRNA Gln ] [tRNA Ile ] Met carboxymethylaminomethyl(34) dephosphorylation 2'-deoxyadenosine F0F1 ATP tRNA ] F1729_RS07620 H + H + nucleoside triphosphate 6 4 synthase synthesis enzyme MnmG: mnmG an N -L- a [protein]- an O - N-acetyl-9-O- N-acetyl-4-O- a [protein]- phosphoenol an N-terminal- an N-terminal- a (1->4)- pyrophosphohydrolase: 2'-deoxyinosine 2'-deoxyguanosine a sulfurated threonylcarbamoyladenine 37 a ferrocytochrome b palmitoyl-CoA methylthymine glu a (6S)-5- serotonin a [glutamine- L-methionyl-L- L-methionyl- ala a cytidine 34 lys α-D-glucan a 5-carboxymethylaminomethyl- 5 L-cysteine acetylneuraminate acetylneuraminate L-glutamine ATP pyruvate UDP-N-acetyl- mazG [sulfur carrier] synthetase]- dADP ATP Ile2 1,4-alpha- 2-thiouridine 34 in tRNA in tRNA in DNA formyltetrahydrofolate alanyl-[protein] glycyl-[protein] α-D-muramate biotin in tRNA dCTP dCMP purine-nucleoside L-tyrosine glucan a reduced sialate O- sialate O- transglutaminase branching H O c-type Carbohydrate Biosynthesis purine-nucleoside phosphorylase: purine-nucleoside tRNA (N(6)-L- acyl-CoA desaturase: methylated-DNA-- bifunctional type I methionyl type I methionyl UDP-N- tRNA 2 nucleoside triphosphate acetylesterase: acetylesterase: domain-containing protein CoxB cytochrome phosphorylase: F1729_RS20760 phosphorylase: threonylcarbamoyladenosine(37) F1729_RS15815 [protein]-cysteine S- folylpolyglutamate glutamine synthetase pyruvate aminopeptidase: aminopeptidase: acetylmuramate- biotin--[acetyl- lysidine(34) an oxidized a 5-aminomethyl-2- pyrophosphohydrolase: F1729_RS20760 F1729_RS20760 methyltransferase: F1729_RS22720 F1729_RS22720 protein: adenylyltransferase: CoA-carboxylase] GlgB: glgB O c-type Fatty Acid and Lipid Biosynthesis gluconeogenesis I S-methyl-5'-thioadenosine -C(2))- methylthiotransferase delta-9 desaturase: synthase/ kinase: pyk map map -L-alanine synthetase α 2 UDP-α-D- 34 mazG sialate O- sialate O- F1729_RS17870 a (1,6)- -D- a reduced CMP-3-deoxy-D- GDP-mannose biosynthesis thiouridine in tRNA degradation IV MtaB: mtaB F1729_RS02290 F1729_RS03650 dihydrofolate F1729_RS07165 ligase: murC ligase: TilS: tilS cytochrome manno-octulosonate galactose Amine and Polyamine Biosynthesis dUTP dUMP acetylesterase: acetylesterase: [+ 5 isozymes] type I methionyl type I methionyl glucosyl-(1,4) H O c-type α methylated-DNA-- synthase: F1729_RS04695 α 2 cytochrome palmitate biosynthesis (S)-malate biosynthesis D-glucopyranose biosynthesis Aromatic Compound Biosynthesis S-methyl-5'- 2-deoxy- -D-ribose 1-phosphate F1729_RS03740 F1729_RS03740 aminopeptidase: aminopeptidase: - -glucan cytochrome octanoyl-[acyl-carrier 6 [protein]-cysteine S- a [glutamine an oxidized fatty acid elongation -- saturated a 2-methylsulfanyl-N -L- F1729_RS15670 map map UDP-N-acetyl- 34 c oxidase (type II fatty acid synthase) D-ribulose 6-phosphate UDP-α-D-glucose thioadenosine5'-methylthioadenosine a [protein] N 6 - pyruvate a lysidine protein] biosynthesis glucose-6- ectoine biosynthesis 37 5'-deoxyadenosine an unsulfurated palmitoleoyl-CoA methyltransferase: synthetase]-O dATP O c-type spermidine biosynthesis I a 5-methylaminomethyl- 5-hydroxy-CTP 5-hydroxy-CMP threonylcarbamoyladenine met a ferricytochrome b α-D-muramoyl- biotinyl-5'- in tRNA Ile2 2 malate 5-phosphate UDP-glucose chorismate biosynthesis I nucleosidase: [sulfur carrier] 5 [(5-hydroxy-1H- 4 -(5'-adenylyl) acytochrome reduced (mitochondria, yeast) phosphate 34 in tRNA F1729_RS25790 N-acetylneuraminate N-acetylneuraminate L-alanine adenylate an acetoacetyl-[acp] dipicolinate biosynthesis 2-thiouridine in tRNA F1729_RS11810 a (6S)-5- acetate acetate indol-3-yl)ethyl]- an N-terminal L- an N-terminal H O c-type an acetoacetyl-[acp] dehydrogenase: isomerase: 4-epimerase -L-tyrosine 2 an acetoacetyl-[acp] aldehydo-D- asp D-erythrose MTR Chlorinated Compound Degradation formyltetrahydrofolate L-glutamine met alanyl-[protein] met glycyl-[protein] cytochrome cytochrome F1729_RS11355 pyruvate F1729_RS08820 GalE: galE SAM a [protein]-S- an oxidized 3-oxoacyl- 3-oxoacyl-[acyl- arabinose 5- UDP-α-D-galactose aspartate kinase: 4-phosphate a thymine in DNA c oxidase F6P 3-deoxy-7- methyl-L-cysteine O c-type [acyl-carrier- carrier-protein] phosphate F1729_RS17235 asp 2 phosphoheptulonate a 5-methylaminomethyl- 2,4-dichlorotoluene degradation Alcohol Degradation acytochrome reduced protein] reductase: fabG oxaloacetate phosphoenolpyruvate mannose-6- aspartate kinase: adenosylmethionine aspartate kinase: 2-(S-geranyl) H O c-type a (3R)-3- synthase: aroF 2 reductase: phosphate decarboxylase: speD F1729_RS17235 34 N 6 -(3-methylbut- an O 6 - an N-terminal- cytochrome hydroxybutanoyl-[acp] synthase: F1729_RS20615 thiouridine in tRNA Secondary Metabolite Degradation 2,4- a [protein]- 3'-dephospho- a nucleoside an L-cysteinyl- pyridoxamine cytochrome fabG a 3-oxoacyl-[acp] isomerase: L-aspartyl- 3-deoxy-7- aspartate kinase: glycerol and glycerophosphodiester degradation 2-en-1-yl)- pyruvate methylguanine 2-oxoglutarate phytanoyl-CoA coenzyme A [EntB aryl- a uracil in DNA MoO - L-methionyl-L- a uridine in tRNA IPP c oxidase an oxidized phosphoenolpyruvate F1729_RS17545 D-arabinofuranose putrescine dAdoMet dichlorotoluene a sulfurated [sulfur carrier] L-cysteine carrier protein] ATP CoA triphosphate RNA ATP 2 [tRNA Cys ] 5'-phosphate IMP O c-type beta-hydroxyacyl- 4-phosphate phosphoheptulonate F1729_RS20615 37 molybdopterin 2 a (3R)-3- carboxykinase phosphoenolpyruvate 5-phosphate F1729_RS18675 adenosine in tRNA in DNA seryl-[protein] tRNA pyridoxamine 4-hydroxy- ACP dehydratase: beta- synthase: L-aspartyl- anhydromuropeptides recycling I glycerol cofactor dihydrouridine Zn 2+ RS21785 Zncytochrome2+ hydroxybutanoyl-[acp] (ATP): pckA synthase: ppsA 3-deoxy-8- D-mannopyranose aspartate- a 5-methylaminomethyl- D-galacturonate phosphate 3-methylbut- 5'/3'- F1729_RS02405 ketoacyl- F1729_RS28870 4-phosphate pyruvate, methylated-DNA-- phytanoyl-CoA holo-[acyl- uracil-DNA synthase phosphooctulonate 6-phosphate semialdehyde spermidine synthase: 3-deoxy- 2-(Se-phospho) GlcNAc-1,6- degradation I tRNA (N6-isopentenyl DNA-directed type I methionyl aminoacyl-tRNA oxidase: 2-enyl nucleotidase beta-hydroxyacyl- [+ 3 isozymes] ACP 3-oxoacyl- (1R,2S)-4,6- phosphate [protein]-cysteine S- dioxygenase: carrier- dephospho- glycosylase: molybdenum cofactor DusB: dusB F1729_RS07875 D-arabino- aspartate- 34 RNA polymerase hydrolase: F1729_RS25565 diphosphate SurE: surE ACP dehydratase: synthase [acyl-carrier- phosphoenol synthase: kdsA phosphomannomutase: dehydrogenase: selenouridine in tRNA anhMurNAc- aldehydo-D- dichloro-3- adenosine(37)-C2)- dikinase: F1729_RS24890 F1729_RS09905 aminopeptidase: pyruvate F1729_RS18140 heptulosonate semialdehyde γ a glycerophosphodiester methylthiotransferase methyltransferase: protein] CoA kinase: subunit omega: guanylyltransferase: map tRNA- F1729_RS22835 pyridoxamine reductase: Zn 2+ RS05190 Zn 2+ F1729_RS02405 a (2E)-but-2-enoyl-[acp] II: fabF protein] F1729_RS07350 L-Ala- -D-Glu- galacturonate methylcyclohexa- F1729_RS23585 phytanoyl-CoA uracil-DNA KDO-8P 7-phosphate dehydrogenase: glycerol MiaB: miaB F1729_RS03650 synthase: F1729_RS09755 F1729_RS19015 F1729_RS09540 dihydrouridine 5'-phosphate ispH inosine [+ 3 isozymes] reductase: phosphopyruvate α-D-mannose L-aspartate 4- spermidine DAP-D-Ala 3,5-diene-1,2-diol 5-chloro-3-methyl- dioxygenase: glycosylase: type I methionyl (E)-4-hydroxy-3- beta- 3-dehydroquinate F1729_RS18140 methylated-DNA-- acpS [+ 2 isozymes] synthase: oxidase: enoyl-ACP fabG hydratase: 1-phosphate semialdehyde a 5-methylaminomethyl- catechol degradation glycerophosphodiester F1729_RS11705 F1729_RS11750 aminopeptidase: methylbut-2-en- ketoacyl- synthase: D-tagaturonate 6 phosphoenol + [protein]-cysteine S- adenylyl F1729_RS07705 Cys reductase: F1729_RS00935 L-aspartate 4- 34 phosphodiesterase: N -(3-methylbut-2-en- H map cys a tRNA F1729_RS08470 1-yl diphosphate 2+ 2+ a (2E)-but-2-enoyl-[acp] diaminobutyrate- 2-selenouridine glycerol pyruvate diphosphate coenzyme A H + a 5,6- Zn RS27575 Zn F1729_RS05900 ACP a (3R)-3- F1729_RS05410 semialdehyde 5-chloro-3- F1729_RS28570 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) an unsulfurated AMP methyltransferase: a holo-[EntB aryl- ADP molybdenum a 2,3,4-saturated phosphopyruvate -2-oxoglutarate in tRNA kinase met 3',5'-ADP dihydrouridine PLP synthase hydroxyacyl-[acyl- N-acetyl-β-D- L-alanyl-γ-D- 4,6-dichloro-3- methylcatechol 37 [sulfur carrier] F1729_RS25790 2-hydroxyphytanoyl- carrier protein] an apyrimidinic uracil RNA cofactor enoyl-ACP [+ 2 isozymes] fatty acyl-[acp] hydratase: α 3-dehydroquinate dihydrodipicolinate GlpK: glpK [+ 2 isozymes] adenosine in tRNA succinate in tRNA II: fabF carrier protein] -Kdo GDP-α-D- transaminase: ectB glucosamine-1,6- glutamyl-meso-2,6- methylcatechol CoA site in DNA an N-terminal reductase: beta-hydroxyacyl- F1729_RS12135 synthetase: met L-seryl-[protein] a butanoyl-[acp] mannose L-2,4- anhydro-N-acetyl- diaminopimeloyl- a [protein]-S- Zn 2+ RS10180 Zn 2+ F1729_RS05900 ACP dehydratase: 2-phospho- 3-deoxy-manno- type I 3- F1729_RS11270 D-altronate sn-glycerol a guanine in DNA diaminobutanoate dehydroquinate (2S,4S)-4- β-D-muramate D-alanine methyl-L-cysteine F1729_RS10325 D-glycerate octulosonate tRNA processing altronate 4-chloro-2-methyl- 3-phosphate a butanoyl-[acp] beta-ketoacyl- dehydratase: hydroxy-2,3,4,5- [+ 3 isozymes] cytidylyltransferase: diaminobutyrate dehydratase: 3,5-dichloro-2- cis,cis-muconate ACP synthase 2,3-bisphosphoglycerate- F1729_RS27580 tetrahydrodipicolinate a metal a metal independent kdsB acetyltransferase: a polycistronic F1729_RS11440 methyl-muconate chloromuconate an L-1- cob(I)alamin- a 3-methyl- DNA with adenine:7,8- a mismatched an [apo BCAA a [lipoyl-carrier a [protein]- an unstable RS21780 beta-ketoacyl- II: fabF an L-lysyl- + L-alanyl-γ-D- 2-oxoglutarate NADPH NAD coenzyme A [EntF L-seryl- an N-acylated- H O a RNA-DNA hybrid 6 cation cation ectA tRNA precursor 1,6-anhydro-N- 2-dehydro- cycloisomerase: phosphatidyl- [corrinoid branched dihydro-8- 2 dehydrogenase protein]-N -[(R) DMAPP RecA filament- ACP synthase beta-ketoacyl- phosphoglycerate CMP-Kdo 3-dehydroshikimate [tRNA Lys ] ATP carrier protein] D-amino acid GTP DNA base pair L-tyrosine β glutamyl-meso- 6 TrkA-N: II: fabF mutase: (2S)-4-acetamido- acetyl- -muramate 3-deoxy-D- chloromuconate chloromuconate F1729_RS19560 DHAP sn-glycerol adenosyltranferase] 2,3,4-saturated oxoguanine mismatch DNA E2 protein] N -dihydrolipoyl]- 4-hydroxy- DNA complexDNA ACP synthase shikimate diaminopimelate cycloisomerase: cycloisomerase: fatty acyl-CoA mismatch F1729_RS02695 F1729_RS04950 2-aminobutanoate dipicolinate gluconate 2-(2-chloro-4-methyl- -dihydrolipoyl- L-lysine dihydrolipoyl 3-methylbut- repair a metal a metal beta-ketoacyl- II: fabF acyl-CoA/acyl-ACP a trans-2- dehydrogenase: F1729_RS19560 F1729_RS19560 Si-specific NAD(P)(+) holo-[acyl- ribonuclease repair protein dihydrolipoyl RS26670 ectoine 5-oxofuran-2-yl)acetate bifunctional phytanoyl-CoA D-aminoacylase: A/G-specific L-lysine dehydrogenase: polysaccharide 2-enyl protein cation cation ACP synthase a 2,3,4-saturated dehydrogenase: enoyl-[acyl- cofactor- glycogen biosynthesis I (from ADP-D-Glucose) aroE ATP:cob(I)alamin transhydrogenase: carrier- elongation HI: rnhA MutS: mutS dehydrogenase: a 3-oxohexanoyl-[acp] synthase: a tRNA precursor a tRNA precursor with N-acetyl-D- lysylphosphatidylglycerol dioxygenase: F1729_RS11075 adenine lpdA biosynthesis diphosphate RecO: II: fabF fatty acyl-[acp] F1729_RS15765 carrier protein] independent 2-(2,4-dichloro- 3,5-dichloro- adenosyltransferase: F1729_RS04060 protein] factor 4: lepA lpdA ectC shikimate with a 5' extension a 5' extension and muramate 6- flippase/synthetase F1729_RS11705 D-aminoacylase: glycosylase: DNA mismatch dihydrolipoyl tyrosine reductase: a stabilizedrecO [+ 2 isozymes] phosphoglycerate 5-oxofuran-2- 2-methyl- F1729_RS13890 Si-specific NAD(P)(+) synthase: [+ 7 isozymes] dihydrolipoyl a 3-oxohexanoyl-[acp] 3-oxoacyl-[acyl- D-glucopyranose 6-phosphate dehydrogenase: and a long 3' trailer a short 3' extension phosphate KDGP MprF: mprF F1729_RS16765 mutY repair dehydrogenase: autokinase: ispH RecA filament- a metal a metal mutase: UDP-N-acetyl-D- ectoine yl)propanoate muconolactone phytanoyl-CoA transhydrogenase: acpS a nucleoside 5'- dehydrogenase: (E)-4-hydroxy-3- RS09825 carrier-protein] aroE ribonuclease D: ribonuclease N-acetylmuramic DNA protein MutS: an [apo BCAA a [lipoyl-carrierlpdA F1729_RS07810 DNA complex cation cation F1729_RS29565 phospho- 2-methyl-cis- 2-methyl-trans dioxygenase: + a [protein]- methylbut-2-en- glucosamine biosynthesis I ribonuclease PH: P protein F1729_RS23290 phosphate H monophosphate lpdA protein]-N 6 -[(R 3-oxoacyl- reductase: fabG enoyl-ACP F1729_RS00955 acid 6- bifunctional dienelactone -dienelactone adenosylcob(III) F1729_RS24890 GDP F1729_RS25170 dehydrogenase L-tyrosine 1-yl diphosphate 3-phospho- sugar mutase: shikimate ribonuclease D: 3-O-L-lysyl-1-O- a holo-[EntF an apurinic site a properly matched 6 F1729_RS25910 component: 4-hydroxy-2- Lys alamin-[corrinoid triphosphate E2 protein] N )-lipoyl]-L-lysine [acyl-carrier- a (3R)-3- reductase: Storage Compound D-glycerate D-glucopyranose F1729_RS25390 phosphate phosphatidylglycerol a tRNA 3',5'-ADP a carboxylate a D-amino acid within DNA phosphate F1729_RS00955 rnpA oxoglutarate adenosyltranferase] a 2-hydroxy-3- L-seryl-carrier adenine DNA base pair -lipoyl-L-lysine protein] hydroxyhexanoyl-[acp] F1729_RS05900 Biosynthesis 6-phosphate shikimate kinase: etherase: murQ 2-chloro-5-methyl- 3-chloro-2-methyl- + a metal a metal glucose-6- α-D-glucopyranose methyl-branched succinate NADH NADP protein] RS19890 reductase: phosphoglycerate F1729_RS24155 a tRNA precursor with N-acetyl-D- aldolase/2- dienelactone dienelactone cation cation beta-hydroxyacyl- phosphate 1-phosphate 2,3,4-saturated fabG cyanophycin metabolism kinase: pgk shikimate kinase: a short 3' extension glucosamine dehydro-3-deoxy- ACP dehydratase: isomerase: glucose-1-phosphate a tRNA precursor 6-phosphate phosphogluconate fatty acyl-CoA a (3R)-3- F1729_RS08820 F1729_RS28865 F1729_RS02405 biotin-carboxyl carrier 13-DPG adenylyltransferase: with a 5' extension aldolase: eda a metal a metal hydroxyhexanoyl-[acp] asp F6P shikimate 3- [+ 3 isozymes] protein assembly F1729_RS05720 2-chloro-5-methyl- 3-chloro-2-methyl- α α N 4 -(β-N-acetyl- (2S,3S)-2,3- 2''-O-acetyl- cation cation phosphate ribonuclease PH: ribonuclease D: di-trans,octa-cis- UDP-N-acetyl- -D-muramoyl- di-trans,octa-cis- UDP-N-acetyl- -D- an apo [peptidyl- a [protein]- a [protein chain an L-asparaginyl- a [protein]-L- RS23515 beta-hydroxyacyl- type I glucose-1-phosphate pyruvate maleylacetate maleylacetate γ γ a ferrocytochrome stearoyl-CoA coenzyme A a [protein]-L-lysine β D-glucosaminyl) dihydroxy-5- N-ethylglycine glutamine-- ribonuclease F1729_RS25910 F1729_RS00955 L-alanyl- -D-glutamyl-L- muramoyl-L-alanyl- -D- L-glutamine (R)- -lysine elongation factor 4-hydroxy-L-threonine a protein Asn ADP-ribose ACP dehydratase: a (2E)-hex-2-enoyl-[acp] a [biotin carboxyl- cyanophycin glyceraldehyde- 3-phosphoshikimate 1- D-glucosamine undecaprenyl phosphate undecaprenyl phosphate b carrier protein] [tRNA ] dGDP methionine ala ala fructose-6- adenylyltransferase: P protein lysyl-D-alanyl-D-alanine glutamyl-L-lysyl-D-alanine 5 EF-P]-L-lysine 34 -L-asparagine ATP-dependent Clp oxohexanedioate peptide- F1729_RS02405 carrier protein]-L-lysine synthetase: 3-phosphate carboxyvinyltransferase: 6-phosphate ribonucleotide- enoyl-ACP phosphate glgC component: protease ATP-binding O-acetyl- methionine a metal a metal [+ 3 isozymes] biotin--[acetyl- cphA triose-phosphate dehydrogenase: aroA Secondary Metabolite Biosynthesis phosphoglucosamine transglutaminase glycine diphosphate RS24345 reductase: transaminase α α rnpA phospho-N- phospho-N- acyl-CoA holo-[acyl- EF-P lysine N(4)-(beta-N- low-specificity subunit ClpX: clpX 2-dehydro-3- aminoacyl-tRNA ADP-ribose (S)-S-oxide cation cation CoA-carboxylase] arg cyanophycin isomerase: gap a (1->4)- -D-glucan ADP- -D-glucose 5-enolpyruvoyl- mutase: glmM domain-containing oxidase reductase: F1729_RS05900 (isomerizing) acetylmuramoyl- acetylmuramoyl- desaturase: carrier- aminoacylase acetylglucosaminyl) L-threonine deoxyglucarate hydrolase: deacetylase: reductase a (2E)-hex-2-enoyl-[acp] ligase: primer-L-aspartate F1729_RS18995 shikimate 3- α protein: ATP-dependent Clp: ThiO: thiO F1729_RS25140 D-glyceraldehyde : glmS glycogen tunicamycin biosynthesis -D-glucosamine Detoxification pentapeptide- protein] aldolase: ltaE F1729_RS22835 MsrA: msrA [+ 2 isozymes] F1729_RS04695 DHAP phosphate myo-inositol D-galactonate degradation pentapeptide- F1729_RS15815 F1729_RS17870 GenX: genX -L-asparaginase: F1729_RS03055 clpP aldolase: F1729_RS15195 F1729_RS25145 a protein-L- 3-phosphate synthase 1-phosphate transferase: mraY synthase: 2+ 2+ enoyl-ACP a [biotin carboxyl- cyanophycin D-glucosamine chorismate UDP-N-acetyl- biosynthesis transferase: mraY delta-9 F1729_RS24680 a peptide F1729_RS26365 methionine- Ca RS17745 Ca a hexanoyl-[acp] 6-phosphate GlgA: glgA UTP arsenate reactive oxygen species degradation acpS [+ 5 isozymes] GDP reductase: carrier protein]-N synthetase: synthase: α-D-glucosamine an uncharged tRNA phenylmercury acetate degradation desaturase: [a protein chain ethylamine glyoxylate (S)-S-oxide 6 D-glucopyranose D-galactonate glycolaldehyde Asn ADP-D-ribose F1729_RS05900 -biotinyl-L-lysine cphA phosphoglucosamine a (1->4)-α-D-glucan aroC nucleoside triphosphate detoxification undecaprenyl-diphospho-N- UMP undecaprenyl-diphospho-N UMP F1729_RS02290 elongation factor N-acetyl-β- gly tartronate asn tRNA acetate beta-ketoacyl- 6-phosphate γ γ a protein with an pyruvate fructose- N-acetyl-α-D- galactonate II (glutaredoxin) acetylmuramoyl-L-alanyl- -D- -acetylmuramoyl-L-alanyl- - a holo [peptidyl- EF-P]-N-(β-L- asp 2+ 2+ mutase: glmM β pyrophosphohydrolase: myo-inositol- superoxide mercuriphenyl 3',5'-ADP N 6 -(γ-glutamyl)- glucosaminylamine semialdehyde Ca RS08670 Ca ACP synthase 1,4-alpha-glucan dTDP- -L-rhamnose chorismate glutamyl-L-lysyl- D-alanyl-D-alanine D-glutamyl-L-lysyl- D-alanine 34 a hexanoyl-[acp] asp bisphosphate α mazG 1-phosphate glucosamine dehydratase: arsenate acetate carrier protein] lysyl)-L-lysine II: fabF cyanophycin -D-glucosamine branching biosynthesis UDP-6-deoxy-5,6-ene- a ferricytochrome L-lysine crosslink a [biotin carboxyl- aldolase class I: 1-phosphate N-acetyl-D-glucosamine synthase: 1-phosphate dgoD arsenate superoxide dismutase: oleoyl-CoA beta-ketoacyl- protein GlgB: glgB α UMP b beta-ketoacyl- F1729_RS08315 -D-glucopyranose F1729_RS25385 lipoprotein posttranslational modification F1729_RS16045 5 carrier-protein dimer]- 2-dehydro-3-deoxy- reductase Co 2+ Co 2+ ACP synthase ACP synthase 6 1-phosphate CorA N -biotinyl-L-lysine cyanophycin class II fructose- a glycogen 5'/3'- Ins(3)P D-galactonate (glutaredoxin) 2+ 2+ II: fabF II: fabF glucose-1-phosphate hydrogen peroxide Mg Mg acetyl-CoA acetyl-CoA synthetase: bisphosphate nucleotidase preQ biosynthesis a [prolipoprotein]- UDP-N-acetyl- : arsC α 0 2+ 2503 an apo-[LYS2 L- a 1-acyl-2- 4-methyl-5-(2- 3''-O-acetyl- (3R,5S)-3- beta-ketoacyl- cphA aldolase: fbaA N-acetyl- -D- thymidylyltransferase UDP-N- SurE: surE inositol L-cysteine α-D-glucosamine acetate benzene Hg a [2-oxoglutarate-dehydrogenase adenine a [protein]- a ribonucleoside N-methyl-L- a 3-oxooctanoyl-[acp] carboxylase carboxylase [+ 2 isozymes] coenzyme A 2-aminoadipyl- FAD arachidonoyl- phosphooxyethyl) a glycyl-[tRNA Ala ] L-threo-3-phenylserine ADP-ribose repressor LexA glucosamine RfbA: rfbA acetylgalactosamine- a sulfurated [sulfur carrier] SAM 6 in 23S rRNA L-threonine hydroxy-1- ACP synthase carboxyltransferase biotin dTDP-α-D-glucose monophosphatase: prolipoprotein arsenite catalase: E2 protein] N -octanoyl-L-lysine dGTP HMP-PP diphosphate tryptophan dADP 1-phosphate 5,6-ene uridine 2-dehydro-3-deoxy- mercuric carrier-protein] sn-glycerol thiazole ribonucleotide- transcriptional pyrroline-5- Mg 2+ MgtE Mg 2+ II: fabF subunit beta: carboxylase arg [cyanophycin]- F1729_RS23735 diacylglyceryl ribonucleotide- 3-oxoacyl-[acyl- dTDP-glucose 4,6- GTP D-galactonate F1729_RS20485 reductase: 3-phosphate CTP diphosphate repressor carboxylatepyrroline-5- F1729_RS16890 subunit: accC L-aspartate transferase: lgt 23S rRNA FAD:protein FMN O-acetyl- diphosphate carrier-protein] β-D-fructose 1,6- PRPP biosynthesis dehydratase: rfbB GTP myo-inositol UDP-N-acetyl-α- 6-phosphate [+ 2 isozymes] F1729_RS17830 holo-[acyl- D-tyrosyl-tRNA(Tyr) reductase: low-specificity N-methyl-L- LexA: lexA carboxylate a 3-oxooctanoyl-[acp] a [carboxyl-carrier a [prolipoprotein]- H O hydroxyl radical lipoyl synthase: (adenine(2503)-C(2) transferase: thiamine ADP-ribose reductase: reductase: fabG bisphosphate dTDP-4-dehydro-6- cyclohydrolase D-glucosamine- 2 F1729_RS08040 carrier- phosphatidate deacylase: F1729_RS25140 L-threonine tryptophan reductase: protein dimer]-N 6 - cyanophycin UDP-N-acetyl- D-ribose 5- S-1,2-diacyl-sn- Hg 0 )-methyltransferase dNTP F1729_RS13795 phosphate deacetylase: repressor F1729_RS25140 Mg 2+ MgtE Mg 2+ α UDP-N-acetyl- enolpyruvate protein] 3-oxoacyl- a (3R)-3- synthetase: α-D-glucosamine phosphate deoxy- -D-glucopyranose I FolE2: glyceryl-L-cysteine arsenite O lipoyl synthase: lipA RlmN: rlmN triphosphohydrolase: dgt cytidylyltransferase: synthase: F1729_RS18615 a 2'- F1729_RS25145 aldolase: ltaE oxidase: solA F1729_RS15195 LexA: lexA proC carboxybiotinyl-L-lysine tunicaminyl-uracil 7,8- 2 synthase: [+ 2 isozymes] F1729_RS25145 [acyl-carrier- hydroxyoctanoyl-[acp] cphA ribose-phosphate dTDP-4- F1729_RS07290 UDP-N- F1729_RS06200 F1729_RS00750 deoxyribonucleoside cleaved Hyp pyrophosphokinase: prs dihydroneopterin acetylmuramate Amine and Polyamine acpS ADP protein] beta-hydroxyacyl- dehydrorhamnose signal D-glyceraldehyde 5'-diphosphate repressor LexA 3'-triphosphate pyruvate Degradation a [2-oxoglutarate dehydrogenase 2503 + + reductase: F6P ribose-phosphate 3,5-epimerase: rfbC peptidase dehydrogenase: 3-phosphate 5'-deoxyadenosine a 2-methyladenine a [protein]-FMN- a CDP-1-acyl- a tRNA Ala benzaldehyde formaldehyde acetate ADP-D-ribose Na RS08020 Na ACP dehydratase: met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] 5'-deoxyadenosine gly gly trp fabG cyanophycin pyrophosphokinase: prs 6-carboxytetrahydropterin II: lspA murB in 23S rRNA met triphosphate a holo-[LYS2 L- L-threonine thiamine F1729_RS02405 dTDP-4-dehydro- N-acetyl- ethanolamine utilization 2'-deoxyguanosine 3',5'-ADP AMP 2-arachidonoyl- fatty acid biosynthesis glucose-6- PRPP β synthase: F1729_RS29520 UDP-N-acetyl- 2-aminoadipyl- phosphate a (3R)-3- [+ 3 isozymes] -L-rhamnose tunicaminyl-uracil glycerol initiation (type II) cyanophycinase: phosphate an (S-diacyl-sn- a lipoprotein α-D-muramate carrier-protein] hydroxyoctanoyl-[acp] dTDP-4- 6-carboxy-5,6,7,8- NADH:ubiquinone F1729_RS13365 isomerase: glyceryl)-L-cysteinyl- signal peptide ethanolamine a (2E)-oct-2-enoyl-[acp] dehydrorhamnose tetrahydropterin UDP-N- + + beta-hydroxyacyl- acetyl-CoA β F1729_RS08820 [apolipoprotein] β Na reductase (Na(+) Na N- -aspartyl- reductase: rfbD 7-carboxy-7- signal peptide a [glycine-cleavage complex H a 2-oxo a [DNA]-3'- a 5'-phospho- DNA containing an [amino-group carrier D-glycero- -D- a (1->4)- acetyl-CoA D-glucopyranose N-acetyl-D- acetylmuramate:L- ethanolamine NAD + coenzyme A an apo-[aryl- a peptide with a a D-tyrosyl- a D-aspartyl- acetyl-CoA -transporting) ACP dehydratase: L-arginine apolipoprotein N- 6 protein]-C-terminal-γ- manno-heptose α enoyl-ACP deazaguanine peptidase alanyl-γ-D- a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine carboxylate hydroxyl [DNA] a base with lesion Tyr asp L-allo-threonine met met -D-glucan F1729_RS02405 carboxylase 6-phosphate dTDP-β-L-rhamnose glucosaminyl-N-acetyl- acyltransferase: lnt ammonia-lyase carrier protein] leader sequence [tRNA ] [tRNA ] 1,4-alpha- reductase: synthase QueE: SppA: sppA glutamyl-meso- (L-glutamyl)-L-glutamate 1,7-bisphosphateD-glycero- methionine- acetyl-CoA [+ 3 isozymes] carboxyltransferase tunicaminyl-uracil subunit EutB: eutB bifunctional glucan F1729_RS05900 F1729_RS25905 an N-acyl-(S-diacyl- signal peptide diaminopimelate acetylglutamate beta-D-manno- R-sulfoxide carboxylase predicted subunit beta: 2-oxoacid:ferredoxin NAD- G/U mismatch- glutamate N- branching [+ 2 isozymes] sn-glyceryl)-L- peptidase ligase: murC acetaldehyde lipoyl synthase: holo-[acyl- signal peptidase: D-tyrosyl-tRNA(Tyr) D-tyrosyl-tRNA(Tyr) kinase: argB low-specificity heptose 1,7- reductase: biotin ABC a (2E)-oct-2-enoyl-[acp] F1729_RS16890 7-carboxy-7- oxidoreductase dependent specific DNA acetyltransferase/ protein a sugar a sugar cysteinyl-[lipoprotein] SppA: sppA F1729_RS08040 carrier- F1729_RS08030 deacylase: deacylase: an [amino-group carrier L-threonine bisphosphate 7- F1729_RS21880 carboxylase transporter malonyl-CoA deazaguanine UDP-N-acetyl- subunit beta: DNA ligase glycosylase: amino-acid GlgB: glgB an octanoyl-[acp] arg asp N-acetyl-D-glucosaminyl- lipoyl synthase: lipA protein] F1729_RS18615 F1729_RS18615 protein]-C-terminal- aldolase: ltaE phosphatase: L-methionine- subunit: accC of a sugar enoyl-ACP 7-cyano-7- α-D-muramoyl- acetaldehyde ethanol F1729_RS02905 LigA: ligA signal F1729_RS08200 acetyltransferase ACP S- tunicaminyl-uracil a peptide synthase: γ-(5-phospho-L- β gmhB (R)-S-oxide [+ 3 isozymes] a GlgE-glycogen reductase: deazaguanine L-alanyl-γ-D- dehydrogenase: dehydrogenase: peptidase I: lepB D-glycero- -D- ArgJ: argJ malonyltransferase: acpS glutamyl)-L-glutamate N-acetyl-L- malonyl-CoA predicted F1729_RS05900 synthase glutamyl-meso-2,6- F1729_RS04220 F1729_RS15065 a [glycine-cleavage complex H a reduced a DNA containing manno-heptose fabD queuosine biosynthesis I (de novo) 5'-deoxyadenosine + a modified Tyr asp acetaldehyde methionine ABC QueC: queC met 6 an unsulfurated [sulfur carrier] an acyl-CoA CO H [DNA] NMN an apurinic/ D-tyrosine a tRNA tRNA D-aspartate gly 1-phosphate a sugar a sugar diaminopimelate protein] N -[(R)-lipoyl]-L-lysine 2 ferredoxin [iron- AMP nucleobase transporter an octanoyl-[acp] sulfur] cluster 3',5'-ADP a holo-[aryl- a leader sequence a peptide apyrimidinic site a malonyl-[acp] a tunicamycin preQ preQ acetyl-CoA ethanol carrier protein] of a sugar acyl-CoA hydrolysis 0 0 C1 Compound Utilization and Assimilation beta-ketoacyl- NADPH-dependent 7- ketoacyl-ACP ACP synthase a 2,3,4-saturated cyano-7-deazaguanine a sugar RS10245 a sugar synthase III: fabH formaldehyde oxidation formate assimilation into 5,10- II: fabF fatty acyl CoA reductase QueF: queF formaldehyde oxidation VI (H MPT pathway) formaldehyde oxidation a [pyruvate dehydrogenase E2 a [histone]-N 6 - 5-dehydro-4- 4-(cytidine 5'- β-D-glucose a glucosylated acyl-CoA 3-oxoacyl-ACP VII (THF pathway) 4 MoO - coenzyme A AsbD acyl- an adenosine 37 a kanamycin preQ methylenetetrahydrofolate 6 ala a pimeloyl-[acp] 2 DMAPP diphospho)-2-C- 5-MTR-1-P glycogenin beta-ketoacyl- [2Fe-2S] iron-sulfur Cofactor, Carrier, and Vitamin Biosynthesis 1 II (glutathione-dependent) a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine a type IV prepilin acetyl-L-lysine a tRNA precursor deoxy-D-glucarate sarcosine 6-phosphate thioesterase: synthase III: superpathway of tetrahydrofolate biosynthesis menaquinol-9 biosynthesis nickel cofactor biosynthesis pyridoxal 5'-phosphate biosynthesis I acetyl phosphate molybdopterin GTP carrier protein in tRNA bifunctional 1,4-alpha- ACP synthase cluster biosynthesis menaquinol-6 biosynthesis NADP molybdopterin methyl-D-erythritol4-(cytidine 5'- myo-inositol- S-methyl-5- fluoride CrcB fluoride F1729_RS27315 F1729_RS29200 formaldehyde formaldehyde cofactor aminoglycoside glucan II: fabF biosynthesis tRNA guanosine(34) formaldehyde formate diphospho) 1-phosphate thioribose-1- [+ 2 isozymes] D-erythrose formaldehyde- acetate/propionate histone phosphotransferase/ 2-dehydro-3- branching a 2,3,4-saturated demethylmenaquinol-9 nicotinate adenine dinucleotide transglycosylase Tgt: tgt formate-- lipoyl synthase: 8-amino-7- holo-[acyl- tRNA (adenosine(37)-N6) prepilin peptidase: -2-C-methyl- synthase: phosphate an acetoacetyl-[acp] L-cysteine desulfurase demethylmenaquinol-6 + activating enzyme: fae family kinase: ribonuclease D: deoxyglucarate a 3-oxodecanoyl-[acp] GTP NAD 4-phosphate tetrahydrofolate molybdenum cofactor carrier- -dimethylallyltransferase deacetylase: ATP-binding protein: glycine oxidase F1729_RS25385 isomerase: protein fatty acid bifunctional a 7-aminomethyl-7- a 5,10- formaldehyde- F1729_RS04235 F1729_RS08040 oxononanoate F1729_RS15700 F1729_RS00955 aldolase: D-erythritol bifunctional NAD(+)/ 34 S-(hydroxymethyl) ligase: F1729_RS10090 F1729_RS16010 ThiO: thiO GlgB: glgB sulfite RS14085 sulfite demethylmenaquinone deazaguanosine in tRNA methylenetetrahydrofolate lipoyl synthase: lipA synthase: bioF guanylyltransferase: protein] MiaA: miaA [+ 5 isozymes] kinase: ispE Ins(3)P mtnA cysteine demethylmenaquinone NADH kinase: activating enzyme: fae glutathione F1729_RS05020 [+ 2 isozymes] a kanamycin F1729_RS26365 2-phospho-4-(cytidine S-methyl-5- 3-oxoacyl- GTP methyltransferase/2- pyridin-1-ium-3,5- tRNA preQ1(34) S- an N 10 - acetate F1729_RS09540 synthase: a glycogen desulfurase: methyltransferase/2- F1729_RS14970 bifunctional 5,10-methylene-tetrahydromethanopterin 3'-phosphate 5'-diphospho)-2-C- thio-D-ribulose [acyl-carrier- cyclohydrolase methoxy-6-polyprenyl- dicarboxylate mononucleotide 4-phospho- adenosylmethionine glutathione- formyltetrahydrofolate acpS N 6 -(3-methylbut- F1729_RS27890 methoxy-6-polyprenyl- NADP + methylenetetrahydrofolate a [pyruvate dehydrogenase (8S)-8-amino-7- a nucleoside 5'- glyoxylate methylamine methyl-D-erythritol 1-phosphate protein] I FolE2: 1,4-benzoquinol ATP-dependent D-erythronate ribosyltransferase- bifunctional NADP-dependent dependent 5'-deoxyadenosine bis(guanylyl 2-en-1-yl)- a cleaved type a tRNA tartronate cysteine 1,4-benzoquinol dehydrogenase/ bifunctional met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] oxononanoate acyl-carrier protein a peptide acetate a [histone]-L-lysine monophosphate pyruvate reductase: F1729_RS07290 methylase UbiE: ubiE sacrificial sulfur isomerase QueA: queA methylenetetrahydromethanopterin formaldehyde molybdopterin) adenosine 37 IV prepilin semialdehyde desulfurase: 7,8- methylase UbiE: ubiE methenyltetrahydrofolate methylenetetrahydrofolate 3',5'-ADP a holo-[AsbD acyl- fabG menaquinol-9 transferase LarE: larE cyclohydrolase FolD: folD dehydrogenase/ dehydrogenase: dehydrogenase/ cofactor carrier protein] in tRNA sufS dihydroneopterin menaquinol-6 5-carboxy-1-(5-O-phospho- 34 a (3R)-3- an epoxyqueuosine in tRNA methylenetetrahydrofolate F1729_RS19800 methenyltetrahydrofolate 3'-triphosphate β-D-ribofuranosyl)pyridin- (3R)-3-hydroxy-2-oxo- a 5,10- hydroxydecanoyl-[acp] phosphatidylserine and an S-sulfanyl-[L- dehydrogenase: F1729_RS23880 glutathione- cyclohydrolase FolD: folD 1-ium-3-carbonyl adenylate 4 phosphooxybutanoate tRNA methenyltetrahydrofolate phosphatidylethanolamine cysteine desulfurase] dependent cob(I)yrinate a,c- 2-phospho-4-(cytidine 5'- a DNA containing a cis-delta21-39- 4-hydroxy-3- (E)-4-hydroxy-3- a protein-L- beta-hydroxyacyl- ATP-dependent 3-phosphoserine/ epoxyqueuosine(34) bifunctional 5,10-methenyltetrahydromethanopterin a 5,10- a homogalacturonan 2251 α-amylose biosynthesis I diamide-[corrinoid α diphospho)-2-C-methyl-D-erythritol guanosine in 23S rRNA carbamoyl L-ornithine leukotriene-D4 methylbut-2-en- methionine- 3',5'-ADP D-glyceraldehyde reductase QueG: queG formaldehyde methenyltetrahydrofolate ATP meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- a mismatch oxo-40-methyl- octaprenylbenzoate thr ACP dehydratase: 7,8- sacrificial sulfur phosphohydroxythreonine pyruvate methylenetetrahydrofolate adenosyltranferase] 23S rRNA phosphate UbiD family 1-yl diphosphate (R)-S-oxide 1,4-alpha- a CDP-diacylglycerol 3-phosphate dehydrogenase: L-alanyl-D-glutamate C59:1-[acp]cyclopropane-fatty- threonine/serine (E)-4-hydroxy- methionine- 3'(2'),5'- F1729_RS02405 transferase LarE: larE transaminase: serC 34 dehydrogenase/ methenyltetrahydromethanopterin bifunctional glucan CDP-diacylglycerol--serine dihydroneopterin a [LarE]-S-[5-carboxy-1-(5-O- a queuosine in tRNA F1729_RS24450 (guanosine(2251)-2'- decarboxylase: 3-methylbut- bisphosphate [+ 3 isozymes] an S-sulfanyl-[cysteine flavin biosynthesis I (bacteria and plants) 4-phosphooxy- methenyltetrahydrofolate cyclohydrolase: F1729_RS23330 methylenetetrahydrofolate pectic acid lyase: 2-C-methyl-D- G/U mismatch- membrane acyl-phospholipid dehydratase: R-sulfoxide branching O-phosphatidyltransferase: 3'-phosphate phosphono-β-D-ribofuranosyl) 1-deoxy-D- O)-methyltransferase ornithine F1729_RS24215 2-enyl- nucleotidase: desulfurase]-[disordered- L-threonine cyclohydrolase FolD: folD dehydrogenase/ ATP:cob(I)alamin UDP-N-acetylmuramoyl- F1729_RS11040 erythritol 2,4- specific DNA dipeptidase: synthase: F1729_RS04505 reductase: protein pssA pyridin-1-ium-3-carbonyl]-L-cysteine xylulose-5- 5-formyl-tetrahydromethanopterin S-formylglutathione L-alanyl-D-glutamate-- cyclodiphosphate RlmB: rlmB carbamoyltransferase: F1729_RS21875 UbiD family diphosphate F1729_RS21880 F1729_RS27090 a (2E)-dec-2-enoyl-[acp] form scaffold 4-hydroxythreonine- an N 10 - methenyltetrahydrofolate adenosyltransferase: pectate lyase: glycosylase: F1729_RS09585 threonine a [protein]-L- GlgB: glgB a 3-sn-phosphatidyl-L-serine GTP ATP-dependent phosphate 2, 6-diaminopimelate synthase: 23S rRNA argF a cis-keto-C60- decarboxylase: 2-C-methyl-D-synthase: ispG protein] complex 4-phosphate formyltetrahydrofolate cyclohydrolase FolD: folD F1729_RS13890 F1729_RS13630 F1729_RS08200 ammonia-lyase, methionine AMP enoyl-ACP [cysteine desulfurase]-S- sacrificial sulfur synthase: ligase: F1729_RS17265 F1729_RS24245 (guanosine(2251)-2'- meroacyl-[acp] F1729_RS24400 erythritol-2,4- amylopectin phosphatidylserine D-erythro-7,8- chorismate dehydrogenase 5-oxo-L-proline metabolism formyltetrahydrofolate a 5,10- biosynthetic: ilvA reductase: sulfanylcysteine:[acceptor superpathway of thiamine diphosphate biosynthesis II transferase LarE: larE dxs O)-methyltransferase leukotriene-E4 2-octaprenylphenol cyclodiphosphate decarboxylase family dihydroneopterin bifunctional PdxA: pdxA bis(guanylyl molybdenum deformylase: methylenetetrahydrofolate a [corrinoid adenosyl-cob(III) an unsaturated uracil gly 2-oxobutanoate F1729_RS05900 protein]-cysteine aminodeoxychorismate/ pyridin-1-ium-3-carboxylate-5- a [protein] with a [protein] with triphosphate α a homogalacturonan RlmB: rlmB L-citrulline an apyrimidinic 3,4-dihydroxy- formate yrinate a,c-diamide UDP-N-acetyl- -D-muramoyl-L-alanyl- pectate CMP 2251 protein: F1729_RS00930 sulfurtransferase: dihydroneopterin 3-amino-1- 1-deoxy-D- cofactor) biosynthesis F1729_RS09900 formate adenosyltransferase] 2-C-methyl-D-erythritol- 2-O-methylguanosine site in DNA a decanoyl-[acyl- anthranilate synthase 2-butanone- thiocarboxylate mononucleotide an N-terminal an N-terminal γ-D-glutamyl-meso-2,6-diaminopimelate oligosaccharide F1729_RS27890 aldolase: folB cys hydroxyacetone xylulose 5- MoO - 2,4-cyclodiphosphate in 23S rRNA carrier protein] an L-1-phosphatidylethanolamine component II: 4-phosphate ATP-dependent 2 L-glutamine L-glutamate formate a [cysteine desulfurase]- 6-(hydroxymethyl) 1-phosphate phosphate molybdopterin F1729_RS00995 synthase/GTP cysteine sacrificial sulfur molybdopterin beta-ketoacyl- S-sulfanyl-[disordered- -7,8-dihydropterin a [ThiS sulfur- cofactor aminodeoxychorismate/ cyclohydrolase II: desulfurase: transferase LarE: larE a ring-opened 7- an sn-glycero-3- a [protein] N- N-methyl-N-[(2S) a [protein]- a (1->4)- ACP synthase form scaffold carrier protein] pyridoxine 5'- α hydrogen (S)-1-pyrroline- cytidine 2-amino-4-hydroxy-6- anthranilate synthase: F1729_RS23450 1-(5-O-phospho-β-D-ribofuranosyl) cob(II)inamide 3-methylbutanoate glycerophosphoserine an N -methyl O-ureido-L- protoheme A(H2) α II: fabF protein] complex F1729_RS27890 phosphate molybdenum cofactor methylguanine phospho-N-(acyl) terminal-formyl- asp -1-phenylpropan- peroxide 5-carboxylate L-tyrosine -D-glucan cysteine hydroxymethyldihydropteridine pabB F1729_RS17790 2,5-diamino-6- -5-(sulfanylcarbonyl)pyridin- a [protein] with ATP L-amino acid homoserine L-glutamate nucleoside 1,4-alpha- cysteine synthase: guanylyltransferase: Carboxylate Degradation in DNA ethanolamine L-methionine 2-yl]hydroxylaminedimethylaniline phosphatepredicted beta-ketoacyl- desulfurase: diphosphokinase: folK (5-phospho-D- 1-ium-3-carbonyl adenylate an N-terminal 5- gamma- deaminase: glucan 4-amino-4- desulfurase: F1729_RS09475 F1729_RS09540 monooxygenase protein-tyrosine ACP synthase F1729_RS27890 ribosylamino) ATP-dependent oxo-L-proline γ acetate- glycerophosphodiester catalase/ F1729_RS02810 branching 2-amino-4-hydroxy-6- deoxychorismate sufS a carboxy- -L-glutamyl DNA- N-methyl-L- peptide argininosuccinate (N-oxide forming) ferrochelatase: semialdehyde II: fabF pyrimidin- sacrificial sulfur glutathione pyruvate decarboxylation to acetyl CoA I ATP:cob(I)alamin -CoA glycerophosphodiester phosphodiesterase: peroxidase phosphatase: nucleoside protein cysteine hydroxymethyldihydropteridine an [L-cysteine adenylated- pyridoxine bis(molybdenum 5-phosphate acetate formamidopyrimidine tryptophan deformylase: synthase: : F1729_RS10885 F1729_RS22430 dehydrogenase: 4(3H)-one transferase LarE: larE pyroglutamyl- adenosyltransferase: ligase: acs phosphodiesterase: F1729_RS28570 (Z)-methyl(oxido) HPI: katG F1729_RS00790 deaminase: GlgB: glgB cyclopropane fatty acid desulfurase: diphosphokinase: folK desulfurase]-S- [ThiS sulfur- a [LarE]-S-[1-(5-O-phosphono-β-D- 5'-phosphate cofactor) Carbohydrate Degradation conversion glycosylase: mutM oxidase: solA def F1729_RS27205 pruA a [protein]- a 3-oxododecanoyl-[acp] (7,8-dihydropterin- bifunctional peptidase a [pyruvate dehydrogenase F1729_RS13890 F1729_RS28570 (1-phenylpropan- F1729_RS06185 sufS sulfanyl-L-cysteine carrier protein] 6 pyruvate [+ 2 isozymes] L-tyrosine starch (CFA) biosynthesis an S-sulfanyl-[cysteine diaminohydroxyphosphoribosylaminopyrimidine ribofuranosyl)-5-(sulfanylcarbonyl) pyridoxamine molybdenum cofactor I: pcp E2 protein] N -lipoyl-L-lysine pyruvate to acetyl-CoA [+ 2 isozymes] 2-ylidene)azanium glu 6-yl)methyl dehydrogenase 3-methylbutanoyl- 2+ uridine 3-oxoacyl- 4-aminobenzoate pyridin-1-ium-3-carbonyl]-L-cysteine guanylyltransferase: superpathway of glucose and xylose degradation a [DNA]- 2,6-diamino-4- Fe protoporphyrin IX A H O a [phospholipid] cis desulfurase]-S- diphosphate deaminase/5-amino-6-(5-phosphoribosylamino) D-glyceraldehyde phosphate acetate a 5'-phospho- adenosylcobinamide diphosphate an N-terminal L- 2 [acyl-carrier- cysteine ATP-dependent F1729_RS09540 heparin degradation (acetyl- nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal AMP CoA sn-glycerol formaldehyde formate canavaninosuccinate -olefinic fatty acid sulfanyl-[disordered- uracil reductase RibD: ribD 3-phosphate oxidase: 5-oxo-L-proline pyruvate acetate- [DNA] triphosphate an N- an L-amino acid methionyl-[protein] protein] cyclopropane-fatty- 5-amino-6-(5- desulfurase: sacrificial sulfur bis(guanylyl D-glucopyranose transferring), 3'-phosphate formamidopyrimidine sn-glycerol 3-phosphate ser form scaffold dihydropteroate F1729_RS25565 dehydrogenase: -CoA acylethanolamine reductase: acyl-phospholipid phospho-D- 1-deoxy-D- F1729_RS27890 transferase LarE: larE molybdopterin) 6-phosphate heparin homodimeric 3-phosphate protein] complex synthase: gly xylulose-5- pyridoxamine F1729_RS11375 type: aceE ligase: acs fabG synthase: [cysteine desulfurase]-S- D-ribulose ribosylamino)uracil cysteine pyridin-1-ium-3,5- cofactor F1729_RS17780 phosphate 5'-phosphate glucose-6- [+ 2 isozymes] acetyl-CoA a [phospholipid]F1729_RS21875 sulfanylcysteine:[acceptor 5-phosphate bifunctional desulfurase: bisthiocarboxylate mononucleotide pyruvate glycine phosphate 4-deoxy-2-O-sulfo- a 7,8-dihydro- 10 a 2'- a peptide with D-glycero-D- 38- a (3R)-3- protein]-cysteine dihydropteroate synthase: sufS oxidase: dehydrogenase: an L-methionyl- an N - an acyl-[acyl- an L-aspartyl- a uridine D-sedoheptulose succinate a phosphate fatty acid containing bifunctional diaminohydroxyphosphoribosylaminopyrimidine oxidase pyridinium-3,5- dehydrogenase: β-L-erythro-hex-4- 8-oxoguanine deoxyribonucleoside an N-terminal manno-heptose RNA a protein arsenate hydroxydodecanoyl-[acp] sulfurtransferase: synthase: folP dxs F1729_RS08470 glu a [pyruvate dehydrogenase a [pyruvate dehydrogenase [initiator tRNA Met ] formyltetrahydrofolate ATP [DNA] [tRNA Asn ] 40 in tRNA 1,7-bisphosphate semialdehyde monoester cyclopropane deaminase/5-amino-6-(5-phosphoribosylamino) ThiO: thiO bisthiocarboxylic zwf F1729_RS11375 in DNA carrier protein] a tRNA precursor 5'-triphosphate 3,4-dihydroxy- 1-deoxy-D- a thiocarboxylated- enopyranuronosyl- 6 6 Xaa-L-proline 7-phosphatebifunctional heptose Asp-tRNA(Asn) RluA family NAD-dependent alkaline arsenate beta-hydroxyacyl- a [cysteine F1729_RS27890 uracil reductase RibD: ribD 6-phospho E2 protein] N - E2 protein] N -S- CTP tail-specific 7,8- 2-butanone- xylulose 5- [ThiS sulfur- acid mononucleotide PLP (1,4)-D-N- 7-phosphate /Glu-tRNA(Gln) pseudouridine succinate- phosphatase: reductase ACP dehydratase: desulfurase]-(S- 5-amino-6-(5- 2-iminoacetate D-glucono- dihydrolipoyl-L-lysine pyruvate acetyldihydrolipoyl-L-lysine class II fructose- protease: dihydropteroate 4-phosphate phosphate carrier protein] nickel chelatase: larC sulfoglucosamine DNA- methionyl-tRNA phosphate DNA leucyl kinase/heptose ribonuclease PH: amidotransferase: synthase: semialdehyde F1729_RS26570 (glutaredoxin) F1729_RS02405 sulfanyl) -[disordered- phospho-D- pyridin-1-ium-3-thioamide-5- periplasmic disulfide bond formation 1,5-lactone dehydrogenase: bisphosphate F1729_RS23000 2 bifunctional synthase/GTP ribitylamino)uracil 6-O-sulfate formamidopyrimidine formyltransferase: acyltransferase CCA tRNA polymerase IV: aminopeptidase: 1-phosphate F1729_RS25910 gatC gatA gatB F1729_RS23285 dehydrogenase: [+ 3 isozymes] : arsC [+ 3 isozymes] form scaffold thiocarboxylate mononucleotide NAD de novo biosynthesis iduronate- F1729_RS11375 an L-asparaginyl- aldolase: fbaA folylpolyglutamate cyclohydrolase II: thiazole synthase: a [DsbB protein] a [DsbA protein] two reduced glycosylase: mutM F1729_RS04320 PlsX: plsX nucleotidyltransferase: F1729_RS21840 F1729_RS11310 adenyltransferase: [+ 2 isozymes] F1729_RS19775 an alcohol a peptide arsenite protein] complex Ni pincer complex I (from aspartate) an electron- 2-sulfatase: [tRNA Asn ] a pseudouridine 38- a (2E)-dodec- synthase/ F1729_RS23450 F1729_RS28580 with reduced L- carrying a cysteine residues F1729_RS18965 [+ 8 isozymes] β F1729_RS26090 succinate transfer quinone F1729_RS16395 D-glycero- -D- a nucleoside 40 in tRNA D-erythrose 2-enoyl-[acp] 1-deoxy-L- AIR bis(guanylyl molybdopterin) cysteine residues disulfide bond in a protein D-gluconate β a [DNA]- RNA dihydrofolate 2-[(2R,5Z)- 4-deoxy- -L- a 5'-phospho- 7,8-dihydro- an N-formyl- a peptide with manno-heptose DHAP 4-phosphate enoyl-ACP glycero-tetrulose cofactor sulfurylation asp 6-phosphate D-mannose nucleotide- 4-oxo-2-pentenal a tetrahydrofolate an acyl phosphate a tRNA a proteinogenic diphosphate synthase: ARP 2-carboxy-4- erythro-hex-4- [DNA] 8-oxoguanine L-methionyl- acyl-carrier protein an N-terminal 1,7-bisphosphate 4-phosphate phosphomethylpyrimidine acetyl-CoA Fatty Acid and met amino acid reductase: a [cysteine desulfurase]- F1729_RS15670 L-aspartate decarboxylating enopyranuronosyl- degradation 3'-phosphate [initiator tRNA ] containing a [DNA] L-proline [scaffold protein- synthase ThiC: thiC methylthiazol-5(2H molybdopterin biosynthesis oxidase: nadB Lipid Degradation 3' CCA end F1729_RS05900 7,8-dihydrofolate cys NADP(+)-dependent (1,4)-D-N- D-mannopyranose (2Fe-2S)] complex 6,7-dimethyl-8- )-ylidene]ethyl 2-iminosuccinate monoglutamate phosphogluconate sulfoglucosamine 6-phosphate β a dodecanoyl-[acp] ribityllumazine HMP-P phosphate mannose-6- oleate -oxidation cysteine cys dehydrogenase: gnd 6-O-sulfate UDP-N-acetyl- decaprenyl-diphospho-N- 46 D-sedoheptulose synthase: quinolinate a 5-L-glutamyl- a D-tryptophanyl- a guanine an L-glutamyl- a [protein]- an unfolded desulfurase: phosphate α-D-glucosamine acetylmuramoyl-pentapeptide an amino acid 2-methylbutanoate glycerophosphoglycerol a tripeptide acetyl-CoA propanoyl-CoA 1-phosphate a protein gly F1729_RS09745 ATP synthase D-ribulose ATP [tRNA Trp ] in tRNA [tRNA Gln ] L-arginine F1729_RS27890 cysteine isomerase: oleate [peptide] tRNA protein beta-ketoacyl- a [co-chaperone]- NadA: nadA 5-phosphate 4'-phosphopantetheine Asp-tRNA(Asn) ATP-dependent protein 2-(2-carboxy-4- desulfurase: F1729_RS18675 (guanosine(46)-N7) chaperonin glycine ACP synthase [scaffold protein- a 7,8-dihydrofolate 6,7-dimethyl-8-(1- cysteine undecaprenyldiphospho- acetate- acetyl-CoA C- /Glu-tRNA(Gln) class II fructose- protease La (LON) arginine kinase: HMP-PP methylthiazol-5- F1729_RS27890 quinolinate N,6-O-disulfo- F6P glycerophosphodiester peptidase -methyltransferase GroEL: groL oxidase II: fabF (2Fe-2S)] complex D-ribityl)lumazine desulfurase: ribulose- ribose 5- muramoylpentapeptide beta-N- -CoA D-tyrosyl-tRNA(Tyr) acetyltransferase: amidotransferase: bisphosphate domain protein: F1729_RS06060 Peptide RS14430 Peptide dihydrofolate yl)ethyl phosphate GTP D-glucosamine gamma- phosphodiesterase: pantetheine-phosphate T: pepT TrmB: trmB a [protein]- [+ 2 isozymes] ThiO: thiO laurate sufS cysteine phosphate 3- phosphate acetylglucosaminyltransferase: ligase: acs deacylase: F1729_RS11190 an N 7 - gatC gatA gatB aldolase: fbaA F1729_RS02920 beta-ketoacyl- reductase: riboflavin an [L-cysteine a carboxy- carboxylating DsbA family glutamyltransferase: ggt F1729_RS06585 adenylyltransferase: an L-glutaminyl- N ω -phospho- desulfurase: epimerase: isomerase oleoyl-CoA murG F1729_RS18615 methylguanine 46 a protein glyoxylate ACP synthase synthase: thiamine nicotinate- Gln a peptide F1729_RS05975 desulfurase]-S- sufS adenylated GTP 3',8- oxidoreductase: D-xylose [+ 2 isozymes] coaD [tRNA ] L-arginine II: fabF a [chaperone-ATP]- F1729_RS00920 phosphate nucleotide rpe B: rpiB (2S)-2- in tRNA sulfanyl-L-cysteine an [L-cysteine [small subunit of cyclase a [DsbB protein] a [DsbA protein] F1729_RS13640 acyl-CoA/acyl-ACP an α-(5-L- a proteinogenic a dipeptide 3-oxopentanoyl- D-erythrose chloride RS16905 chloride [co-chaperone]- a tetrahydrofolate biotin biosynthesis from synthase: diphosphorylase: an electron- an intra- xylose ribose 5- N-sulfo-D- decaprenyl-pyrophosphoryl- UDP methylbutanoyl- diphosphate DHAP cysteine desulfurase]-S- molybdopterin dehydrogenase: glutamyl)- AMP Trp amino acid CoA [scaffold protein- riboflavin F1729_RS00750 MoaA: carrying a with reduced L- isomerase: D-xylulose phosphate glucosamine (N-acetylglucosamine)-N- a peptide glycerol sn-glycerol D-tryptophan a tRNA a 3-oxotetradecanoyl- lauroyl-CoA 8-amino-7-oxononanoate I desulfurase: sulfanyl-L-cysteine synthase] nadC transfer quinol protein disulfide F1729_RS15765 amino acid CoA 3'-dephospho-CoA (2Fe-2S)] complex bis(guanylyl moaA disulfide bond cysteine residues xylA 5-phosphate isomerase acetylmuramyl-(pentapeptide) 3-phosphate [acp] bifunctional (8S)-8-amino-7- F1729_RS27890 (8S)-3',8-cyclo-7,8- transketolase: acyl-CoA/acyl-ACP thiamine molybdopterin) NaMN B: rpiB riboflavin kinase/ oxononanoate cysteine molybdopterin- dihydroguanosine D-xylulose F1729_RS02935 dehydrogenase: 3-oxoacyl- adenosylmethionine- phosphate cofactor FAD synthetase: desulfurase: synthase 5'-triphosphate nicotinate-nucleotide [+ 2 isozymes] GDP-α-D- trans,octacis 37 1498 [acyl-carrier- folate transformations III (E. coli) -8-amino-7- xylulokinase: D-ribose 5- D-glucosamine F1729_RS16500 an oxidized a reduced sn-glycero-3- a glycogen fumarate methylglyoxal a guanine a uracil squalene roseoflavin a [protein]- histidinol sulfurylase: cyclic pyranopterin 6 37 -decaprenyl protein] a [chaperone- F1729_RS17510 thiamine- sufS adenylyltransferase: N -L-threonylcarbamoyladenosine phosphate (2E,9Z)- mannose DL-allothreonine phosphoethanolamine a PII protein asp in tRNA in 16S rRNA L-histidine D-ala an [2Fe-2S] oxononanoate a [bis(guanylyl F1729_RS05995 monophosphate xylB phosphate cytochrome cm552 cytochrome c554 UTP squalene-- bifunctional reductase: phosphatidylglycerol ADP]-[disordered- monophosphate F1729_RS07325 -modified tRNA biosynthesis octadecenoyl-CoA glyoxalase/bleomycin tRNA 16S rRNA histidinol cluster protein a tetrahydrofolate FMN transaminase: bioA molybdopterin) [bis-MGD synthase D-xylulose hopene cyclase: riboflavin kinase/ histidine kinase: glycine fabG biosynthesis II (non-plastidic) form scaffold (7R,8S)- kinase: nicotinate adenine D-sedoheptulose D-glyceraldehyde alpha-glucan resistance protein/ (guanosine(37)-N1) (uracil(1498)-N(3))- dehydrogenase: cofactor cofactor a thiocarboxylated MoaC: moaC 5-phosphate polyprenol glycerophosphodiester L-aspartate F1729_RS23250 FAD synthetase: F1729_RS15575 oxidase a (3R)-3- protein] complex bifunctional diaminononanoate F1729_RS15785 dinucleotide thr 7-phosphate 3-phosphate serine family [protein-PII] dioxygenase: -methyltransferase methyltransferase: hisD chaperone]-S- chaperone]- [small subunit of cyclic monophosphomannose cytochrome c554: phosphodiesterase: oxidase: F1729_RS21960 TrmD: trmD F1729_RS27340 F1729_RS17510 a [protein]- ThiO: thiO hydroxytetradecanoyl- DHAP methionine riboflavin kinase/ dethiobiotin thiamine NAD+ synthase: threonylcarbamoyl- hydroxymethyltransferase: phosphorylase: uridylyltransferase: an N 1 - an N 3 - squalene-- sulfanyl-L-cysteine bis-MGD molybdopterin pyranopterin NAD+ synthase: synthase: F1729_RS17455 F1729_RS23120 F1729_RS28570 nadB roseoflavin N-phospho- his pyruvate [acp] synthase: FAD synthetase: synthase: bioD diphosphate F1729_RS27255 AMP synthase: transaldolase: (S)-3-hydroxy-(9Z) F1729_RS18205 glgP glnD [+ 2 isozymes] methylguanine 37 methyluracil 1498 hopene cyclase: synthase] phosphate F1729_RS27255 [+ 2 isozymes] 5'-phosphate L-histidine beta-hydroxyacyl- metH F1729_RS17510 [+ 2 isozymes] F1729_RS00415 F1729_RS00305 fucose degradation -octadecenoyl-CoA trans,octacis- (R)-lactate in tRNA in 16S rRNA F1729_RS06145 sn-glycerol an [Fe-S cluster dihydrofolate dethiobiotin NADPH repair (eukaryotes) (L-threonylcarbamoyl) ACP dehydratase: molybdopterin decaprenylphospho- an oxidized a reduced α-D- 2-iminosuccinate succinate hop-22(29)-ene biosynthesis reductase: FAD NAD + adenylate D-erythrose GDP acetaldehyde an α-limit dextrin a uridylylated F1729_RS02405 3-phosphate synthase: F6P β-L-fucopyranose β-D-mannose gly ethanolamine sn-glycerol glucopyranose chaperone]-ATP F1729_RS05975serine biotin sulfo-bis(guanylyl tRNA (adenosine(37)-N6)- 4-phosphate cytochrome c554 cytochrome cm552 PII protein [+ 3 isozymes] glycerol-3- thiamine diphosphate F1729_RS02980 NADPH 3-phosphate 1-phosphate a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate synthase phosphopantothenate biosynthesis I molybdopterin) threonylcarbamoyltransferase 3-oxo-(9Z)- phosphate 1-O- glycine cleavage system biosynthesis I (E. coli) transketolase: L-fucose a (2E)-tetradec- F1729_RS18205 BioB: bioB cofactor complex dimerization mutarotase: octadecenoyl-CoA 2-enoyl-[acp] acyltransferase aminomethyltransferase 2-[(2R,5Z)- F1729_RS02935 3-methyl-2-oxobutanoate molybdopterin subunit type 1 TsaB: tsaB F1729_RS22765 3-ketoacyl- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N dehypoxanthine (1S,2R)-1- a [release factor]- guanine 37 dCDP PlsY: plsY GcvT: gcvT a (6S)-5- 9-mercaptodethiobiotin 2-carboxy-4- dipyrromethane [+ 2 isozymes] + a D-aminoacyl- an N-modified malonyl-CoA H + a DNA segment a dipeptide long chain bacillithiol biosynthesis CoA thiolase: γ SAM H hydrogencarbonate Phe chorismate enoyl-ACP a 1-acyl-sn bifunctional cofactor biosynthesis [+ 2 isozymes] -acetylmuramoyl-L-alanyl- - futalosine ser C-(indol-3- [tRNA] aminoacyl-[tRNA] L-glutamine in tRNA a phosphorylase b polyphosphate ribonucleotide- [+ 2 isozymes] formyltetrahydrofolate 3-methyl-2-oxobutanoate methylthiazol-5(2H S-adenosyl-L-methionine salvage II an N 6 -L- D-glyceraldehyde α-L-fucopyranose F1729_RS11190 peptide chain tRNA recombinase reductase: -glycerol 3- methylenetetrahydrofolate biotin D-glutamyl-L-lysyl- D-alanine yl)glycerol membrane diphosphate hydroxymethyltransferase: )-ylidene]ethyl an apo-[hydroxymethylbilane UDP-N-acetyl- (R)-NADPHX NAD(P)H-hydrate threonylcarbamoyladenine 37 3-phosphate release factor (guanosine(37)-N1) phosphorylase RecA: recA chorismate F1729_RS05900 phosphate dehydrogenase/ synthase HMP-PP (S)-malate fucose isomerase: undecaprenyldiphospho- 3-phosphate dipeptidase: polyphosphate reductase: methylenetetrahydrofolate panB phosphate synthase]-L-cysteine α-D-glucosamine epimerase: in tRNA (7Z)-hexadecenoyl-CoA dehypoxanthine carbonic anhydrase: type III polyketide N(5)-glutamine -methyltransferase kinase: recombinase mutase: aroH 1-acyl-sn-glycerol- methenyltetrahydrofolate BioB: bioB SAH type I F1729_RS22765 muramoylpentapeptide beta-N- D-tyrosyl-tRNA(Tyr) aminoacyl-tRNA F1729_RS09585 kinase 2: ppk2 F1729_RS25140 a myristoyl-[acp] reductase [NAD(P)H]: metF F1729_RS29500 D-galactose degradation I (Leloir pathway) futalosine F1729_RS10225 tryptophan synthase: methyltransferase: TrmD: trmD F1729_RS27145 RecA: 3-phosphate a 5,10- cyclohydrolase FolD: folD a 5,10- 2-dehydropantoate glyceraldehyde- acyl-CoA/acyl-ACP acetylglucosaminyltransferase: deacylase: hydrolase: an N 1 - F1729_RS25145 biotin thiamine adenosylhomocysteinase: (S)-NADPHX cyclase: mqnC carbonic anhydrase: synthase: trpB F1729_RS20455 prmC F1729_RS25255 a proteinogenic long chain prephenate acyltransferase: methenyltetrahydrofolate a [hydroxymethylbilane 3-phosphate L-fuculose dehydrogenase: murG F1729_RS18615 F1729_RS22835 methylguanine 37 a phosphorylase a beta-ketoacyl- methylenetetrahydrofolate phosphate F1729_RS29435 β-D- F1729_RS10625 F1729_RS26130 a [release factor]-N 5 a DNA segment amino acid polyphosphate CDP F1729_RS14950 synthase] ES intermediate dehydrogenase: Phe bifunctional synthase: 2 NAD(P)H-hydrate galactopyranose F1729_RS15765 cyclic in tRNA in reverse ACP synthase L-homocysteine (S)-malyl N-acetyl- gap ditrans,octacis-undecaprenyldiphospho- -methyl-L-glutamine 1-acyl-sn-glycerol- methylenetetrahydrofolate F1729_RS00750 hydroxymethylbilane dehydratase: aldose 1- acyl-CoA/acyl-ACP UDP 5'-deoxyadenosine dehypoxanthine D-glyceraldehyde octoketide orientation II: fabF α-D-glucosaminide Respiration N-acetyl-(N-acetylglucosaminyl)muramoyl- met an uncharged an N-modified an uncharged 3-phosphate dehydrogenase/ β-alanine synthase: hemC 5-methyltetrahydropteroyltriglutamate- F1729_RS24875 epimerase: dehydrogenase: futalosine CO H O 3-phosphate trp a D-amino acid beta-ketoacyl- (R)-pantoate bacillithiol 13-DPG L-fuculose L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine 2 2 tRNA amino acid tRNA acyltransferase: folate polyglutamylation methenyltetrahydrofolate thiamine a [hydroxymethylbilane - homocysteine S- F1729_RS27865 F1729_RS16500 ACP synthase biosynthesis NADPH 1-phosphate F1729_RS09470 cyclohydrolase FolD: folD phosphate synthase] ES intermediate methyltransferase: metE 2-oxoglutarate decarboxylation to succinyl-CoA galactose-1- (2E,7Z)- II: fabF a 1,2-diacyl- 3 deacetylase phosphoglycerate 10 pantoate--beta-alanine hexadecenoyl-CoA a tetrahydrofolate an N - methionine synthase: metH epimerase: α undecaprenyl-diphospho-N-acetylmuramoyl-L- 34 a thiocarboxylated an N-formyl-L- UDP-N-acetyl- β-D-fructofuranose an [RNA]-3'- (2Z,4Z)-2- a 3-oxohexadecanoyl- sn-glycerol thiamine- hydroxymethylbilane BshB1: bshB1 a [2-oxoglutarate kinase: pgk UDP-N-acetyl- -D-glucosamine a single a uridine an (S)-2- propionamide UDP phosphoenol formyltetrahydrofolate ligase: F1729_RS23950 F1729_RS24800 alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine [SAMP] C- methionylaminoacyl- α-D-glucosamine 1-phosphate ribonucleoside- methamphetamine hydroxyhepta- 2-chloroacetate [acp] 3-phosphate monophosphate synthase: hemC (S)-malyl α-D- dehydrogenase 3-phospho- stranded DNA in tRNA halocarboxylate GTP ribonucleotide- pyruvate met 6 α-D- terminal glycine tRNA 2',3'- dimethylaniline 2,4-dienedioate haloacid amidase: phosphatidate formate-- bifunctional serine kinase: a [hydroxymethylbilane glucosaminide E2 protein] N 2-oxoglutarate D-glycerate undecaprenyldiphospho- 2-hydroxyhepta- diphosphate 3-oxoacyl- (R)-pantothenate galactopyranose DHAP (S)-lactaldehyde cyclophosphate monooxygenase diguanylate cyclase: dehalogenase F1729_RS14080 pyruvate cytidylyltransferase: tetrahydrofolate folylpolyglutamate hydroxymethyltransferase: F1729_RS15785 synthase] ES intermediate methionine -lipoyl-L-lysine dehydrogenase (S)-3-hydroxy-(7Z) muramoylpentapeptide beta-N- exodeoxyribonuclease HAD family UDP-N- class II fructose- RNA 2',3'-cyclic 2,4-diene-1,7- reductase: [acyl-carrier- 4 2,3-bisphosphoglycerate- tRNA 2- (N-oxide forming) F1729_RS10065 type II: amidase: kinase: pyk F1729_RS06200 F1729_RS18205 2-oxoglutarate E1 component: acetylglucosaminyltransferase: VII: xseA peptide acetylglucosamine bisphosphate phosphodiesterase: dioate isomerase: F1729_RS25140 protein] ligase: synthase/ NAD salvage pathway V (PNC V cycle) type III pantothenate thiamine hydroxymethylbilane adenosyltransferase: independent -hexadecenoyl-CoA thiouridine(34) hydrolase: : F1729_RS10885 F1729_RS02195 F1729_RS15810 a CDP- dehydrogenase F1729_RS09845 murG F1729_RS27130 deformylase: 2-epimerase aldolase: fbaA thpR N-methyl-N-[(2S) F1729_RS25535 diguanylate cyclase: F1729_RS25145 reductase: F1729_RS05020 dihydrofolate kinase: F1729_RS27135 diphosphate synthase: hemC F1729_RS19080 phosphoglycerate synthase F1729_RS17930 an [RNA]-3'- (4Z)-2-oxohept- pyruvate diacylglycerol E1 component: α-D-galactose def (hydrolyzing): neuC -1-phenylpropan- F1729_RS27025 glycolate propanoate fabG synthase: a 5,10- bacillithiol mutase: UDP-α-D-glucose MnmA: mnmA [+ 4 isozymes] ribunucleoside- 4-enedioate c-di-GMP dUDP 10 + a holo-[hydroxymethylbilane a (3R)-3- CDP-diacylglycerol-- an N - F1729_RS15670 methylenetetrahydrofolate NAD NAD-dependent (R)-4'-phosphopantothenate SAM F1729_RS09845 1-phosphate ditrans,octacis-undecaprenyldiphospho-N- 2'-phosphate 2-yl]hydroxylamine F1729_RS04950 UDP a ribonucleoside a single-stranded α D-glyceraldehyde glycerol-3-phosphate 3- formyltetrahydrofolate deacylase: synthase] [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate 3-oxo-(7Z)- β N-acetyl- -D- UDP DHAP hydroxyhexadecanoyl- bifunctional acetyl-(N-acetyl- -D-glucosaminyl)muramoyl-L- oligodeoxyribonucleotide 34 a L-methionylaminoacyl- menaquinol-7 biosynthesis cofactor- hexadecenoyl-CoA 5'-monophosphate a [SAMP] C- a 2-thiouridine formate a (2R)-2- mannosamine [acp] phosphatidyltransferase: bifunctional folylpolyglutamate NAD+ synthase: F1729_RS20060 molybdenum cofactor biosynthesis cytidylyl molybdenum dehydrogenase dehydrogenase alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine tRNA a halide anion a tetrahydrofolate 6 6 independent 3-ketoacyl- terminal glycine in tRNA hydroxy fatty acid beta-hydroxyacyl- pgsA folylpolyglutamate synthase/ F1729_RS27255 cofactor sulfurylation E2 protein] N E2 protein] N -S- all-trans- phosphoglycerate CoA thiolase: ACP dehydratase: 1-(3-sn- synthase/ dihydrofolate thioredoxin pathway -dihydrolipoyl- succinyldihydrolipoyl- molybdate cytidylyl molybdenum heptaprenyl 1,4-dihydroxy- mutase: UDP- F1729_RS11190 F1729_RS02405 phosphatidyl) synthase: nicotinate adenine dinucleotide nicotinamide lipoate biosynthesis L-lysine L-lysine ADP-L-glycero-β- heptosyl- 34 dihydrofolate cofactor (trioxo) diphosphate 2-naphthoate F1729_RS29565 glucose 4- a sulfurated 2-amino-6-[1-hydroxyethyl]- an (R)-2- an (R)-2- a holo [BryP acyl- a cytidine D-ribofuranose -sn-glycerol F1729_RS15670 bifunctional molybdopterin and incorporation I an oxidized dethiobiotin SAM D-manno-heptose Kdo -lipid A 2-oxoglutarate ectoine canavaninosuccinate hydantoin MEP (S)-nicotine acrylamide wound RNA [+ 3 isozymes] synthase: molybdate ABC epimerase (5Z)-tetradecenoyl-CoA [sulfur carrier] 7-methyl-7,8-dihydropterin 2 halocarboxylate halocarboxylate in tRNA 3-phosphate 2-phospho- 2-amino-4-hydroxy-6- carrier protein] tRNA (cytidine(34) dimethylaniline amidase: ATP- a (2E)-hexadec- F1729_RS15670 a 5,10- nicotinamidase/ molybdopterin transporter thioredoxin GalE: galE 1-deoxy-D-xylulose- nicotinate-nucleotide an [MCD cofactor D-glycerate hydroxymethyldihydropteridine ACP S- -2'-O)- hydantoinase: monooxygenase F1729_RS14080 dependent ribokinase: phosphatidylglycerophosphatase 10 methylenetetrahydrofolate pyrazinamidase: pncA adenylyltransferase: substrate-binding an octanoyl-[acp] 2-oxoglutarate acyl-CoA/acyl-ACP lipopolysaccharide 5-phosphate 2-enoyl-[acp] an N - adenylyltransferase: chaperone]-MCD phosphopyruvate diphosphokinase: folK HAD family HAD family ectoine malonyltransferase: F1729_RS23305 rbsK A: F1729_RS09565 F1729_RS10200 protein: modA octanoyl glycolysis IV Glycolysis dehydrogenase dehydrogenase: biotin heptosyltransferase argininosuccinate methyltransferase: reductoisomerase: (N-oxide forming) amidase: RNA helicase enoyl-ACP formyltetrahydrofolate F1729_RS07325 NaMN nicotinate hydratase: hydrolase: hydrolase: hydroxylase: fabD an L-1- transferase: cysteine demethylmenaquinol-7 thioredoxin- E1 component: F1729_RS15765 synthase 2-amino-4-hydroxy-6- II: waaF lyase: argH a malonyl- a 2'-O- F1729_RS17960 F1729_RS04090 : F1729_RS10885 F1729_RS15810 HrpA: hrpA D-ribofuranose reductase: molybdopterin F1729_RS00935 F1729_RS17930 F1729_RS17930 thpD 1-deoxy-D- nicotine- phosphatidyl- molybdate desulfurase: disulfide α-D- BioB: bioB hydroxymethyldihydropteridine 34 N-carbamoylglycine acrylate an unwound RNA 5-phosphate adenine dinucleotide a [lipoyl-carrierF1729_RS08050 protein] F6P F1729_RS09845 UDP-α-D- acyl-CoA/acyl-ACP [BryP acyl- methylcytidine xylulose 5- 1'-N-oxide F1729_RS05900 sn-glycerol guanylyl molybdenum F1729_RS27890 bifunctional reductase: phosphopyruvate glucopyranose diphosphokinase: folK [+ 3 isozymes] [+ 3 isozymes] bis(guanylyl tungstenpterin) N 6 -octanoyl-L-lysine 2-oxoglutarate dehydrogenase: [1-(2-amino-7-methyl-4-oxo- (heptosyl) - carrier protein] in tRNA phosphate demethylmenaquinone galactose 2 cofactor biosynthesis menaquinol-8 biosynthesis nicotinate cofactor biosynthesis cysteine F1729_RS17445 diphosphate--fructose- hydratase: 1-phosphate F1729_RS16500 biotin 5'-deoxyadenosine an unsulfurated 7,8-dihydro-3H-pteridin- Kdo -lipid A 5-hydroxyectoine succinate L-canavanine fumarate a palmitoyl-[acp] acyl carrier molybdopterin lipoyl synthase: ATP-dependent 6- dehydrogenase met 2 phosphoribosyltransferase: MoO - desulfurase: sufS methyltransferase/2- 6-phosphate 1- F1729_RS12135 [sulfur carrier] ADP an (S)-2- a (2R)-2- 2 molybdotransferase complex (2E,5Z)- 6-yl)]ethyl diphosphate protein F1729_RS08040 a [cytidylyl molybdenum methoxy-6-polyprenyl- phosphofructokinase: phospho- (1,4)-β-D-xylan a halide anion a halide anion F1729_RS06475 molybdopterin MoeA: phosphotransferase: dihydrolipoyllysine- phosphoenol tetradecenoyl-CoA hydroxycarboxylate hydroxy fatty acid activation demethylmenaquinol-8 lipoyl cofactor chaperone]- 1,4-benzoquinol a reduced F1729_RS27555 sugar mutase: degradation bis(tungstenpterin) GTP cofactor molybdenum cofactor F1729_RS00990 F1729_RS17925 residue pyruvate an apo acyl- bifunctional synthase: lipA cytidylyl molybdenum methylase UbiE: ubiE thioredoxin F1729_RS25390 cofactor guanylyltransferase: β-D-fructose 1,6- succinyltransferase: β a [protein]- carrier protein demethylmenaquinone guanylyl a [lipoyl-carrier cofactor (sulfo-dioxo) pyruvate a (1->4)- -D-xylan an (S)-2- 2-deoxy-D-ribose a 3,5,7,9,11,13,15- an insertion sequence (3Z)-hex- L-malic holo-[acyl- F1729_RS09540 6 menaquinol-7 bisphosphate odhB D-glucopyranose a 5,10- a uridine 34 a proteinogenic leukotriene-C4 isobutanoate hydroxypyruvate a holo [BryU acyl- ethylphosphate N π -phospho- CAIR palmitate methyltransferase/2- molybdenum MoO -molybdopterin cofactor protein]-N -[(R)- kinase: pyk endo-1,4-beta- gly halocarboxylate 5-phosphate hepta-oxo- element IS30 3-en-1-ol semialdehyde carrier- molybdenum cofactor 2 6-phosphate methylenetetrahydrofolate in tRNA amino acid carrier protein] CHAT domain- L-histidine methoxy-6-polyprenyl- cofactor dihydrolipoyl]-L-lysine xylanase: (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) hexadecanoyl-[PKS-acp]aldo/keto transposase: alkaline aldehyde 5-(carboxyamino) protein] guanylyltransferase: fructose- pyruvate F1729_RS24410 ACP S- containing protein: phosphohistidine dehydrogenase imidazole 1,4-benzoquinol a (1->4)-β-D-xylan 3,5-dienoyl-CoA -tetradecenoyl-CoA pyruvate reductase: F1729_RS09960 phosphatase: synthase: F1729_RS09540 bisphosphate tRNA uridine-5- acetate--CoA HAD family deoxyribose- malonyltransferase: F1729_RS03400 phosphatase (NADP(+)): ribonucleotide methylase UbiE: ubiE oligosaccharide acyl-CoA dehydrogenase: F1729_RS17955 [+ 9 isozymes] F1729_RS07740 acpS aldolase class I: NADH repair (eukaryotes) carboxymethylaminomethyl(34) gamma- ligase: acs hydrolase: phosphate fabD an insertion [+ 2 isozymes] SixA: sixA F1729_RS12530 mutase: purE a holo acyl- menaquinol-8 thioesterase: F1729_RS11375 9-hydroxy-3,5,7,11,13,15-[+ 3 isozymes] a malonyl- [+ 3 isozymes] palmitoyl-CoA bis(guanylyl F1729_RS08315 synthesis enzyme MnmG: mnmG glutamyltransferase: ggt F1729_RS17930 aldolase: sequence IS30 with (3Z)-hex-3- a [protein]- carrier protein F1729_RS27315 hexaoxohexadecanoyl- [BryU acyl- ethanol (S)-malate AIR tungstenpterin) cofactor 3-oxo-(5Z)- [+ 3 isozymes] deoC integrated transposon en-1-yl acetate L-histidine class II fructose- NADH [+ 2 isozymes] [PKS-acp] carrier protein] bisphosphate (S)-lactate (R)-lactate β tetradecenoyl-CoA isobutanoyl-CoA -D-xylopyranose (3E,5Z)- a 5-carboxymethylaminomethyluridine 34 an α-(γ-L-glutamyl) diphosphate CO glycolyl-CoA NADH Nucleoside and Nucleotide Biosynthesis 3-ketoacyl- a 7,8-dihydrofolate leukotriene-D4 AMP D-glyceraldehyde 2 aldolase: fbaA tetradecadienoate in tRNA -L-amino acid a halide anion an (S)-2- acetaldehyde CoA thiolase: hydroxycarboxylate 3-phosphate UMP biosynthesis III F1729_RS11190 superpathway of guanosine inosine-5'-phosphate biosynthesis I guanine and guanosine salvage II pyrimidine deoxyribonucleotides de novo biosynthesis III adenine and superpathway of adenine and adenosine salvage III triose-phosphate (3Z)-dodec- nucleotides de novo biosynthesis I adenosine nucleotides adenosine isomerase: (R)-NADHX a purine base 3-[(1-carboxyvinyl) a [protein]-S- a uridine 34 a cis-delta19- a guanine 966 a monocarboxylic α-D-glucosamine Amino Acid Degradation 3-enoyl-CoA a proteinogenic glutathione methyl red pyruvate amphetamine D-glucopyranose acetaldehyde gln hydrogencarbonate de novo biosynthesis I AIR UDP CTP salvage VI F1729_RS18995 D-glyceraldehyde NAD(P)H-hydrate lesion in DNA oxy]benzoate SAM sulfanyl-L-cysteine in tRNA 37-methoxy-38- in 16S rRNA acid amide thr 6-phosphate amino acid glucose 1- 5-(carboxyamino) guanosine ribonucleotide- adenine DHAP 3-phosphate epimerase: methyl-C57:1-[acp]cyclopropane-fatty- 16S rRNA dimethylaniline amidase: aldehyde glucosamine- IMP dehydrogenase: L-threonine 3- IMP imidazole ribonucleotide diphosphate reductase: purine-nucleoside adenosine (S)-NADHX F1729_RS29500 L-threonine degradation I acyl-phospholipid (guanine(966)-N(2) monooxygenase F1729_RS14080 dehydrogenase 6-phosphate asp CDP L-glutamate L-citrulline degradation L-glutamate L-glutamate DNA- aminofutalosine tRNA 2- FMN-dependent pyruvate F1729_RS04510 dehydrogenase: glutamine- synthase: F1729_RS25900 F1729_RS25140 phosphorylase: (2E)-dodec- synthase: )-methyltransferase (N-oxide forming) amidase: (NADP(+)): deaminase: IMP adenosine kinase: type I NAD(P)H-hydrate degradation VI degradation X degradation I formamidopyrimidine gamma- synthase thiouridine(34) NADH- dehydrogenase: F1729_RS04970 hydrolyzing N5-CAIR F1729_RS25145 ribonucleotide- F1729_RS20760 2-enoyl-CoA 2 RsmD: rsmD : F1729_RS10885 F1729_RS15810 [+ 2 isozymes] F1729_RS12530 nagB dehydrogenase: F1729_RS27845 glyceraldehyde- dehydratase: glycosylase: mutM glutamyltransferase: ggt synthase azoreductase: F1729_RS11375 F1729_RS21875 an N - N-(1-phenylpropan- carbamoyl- guanine dUDP thr (to pyruvate) MqnE: mqnE a cis-methoxy- 966 D-glucono- aminoacetone adenylosuccinate diphosphate reductase: adenosine 3-phosphate L-citrulline MnmA: mnmA F1729_RS26810 methylguanine a monocarboxylate acetate F6P phosphate guaB F1729_RS24875 threonine/serine glu glu C59-meroacyl-[acp] 2-yl)hydroxylamine 1,5-lactone synthase: 5-(carboxyamino)imidazole nucleoside-diphosphate F1729_RS25140 AMP dehydrogenase: glu ornithine in 16S rRNA synthase dehydratase: a [DNA]- a 5'-phospho- a modified 6-amino-6- F1729_RS22775 ribonucleotide mutase: purE hypoxanthine kinase: F1729_RS22750 F1729_RS25145 adenosine gap phosphoglycerate NADH carbamoyltransferase: glutamate glutamate 4-oxo-2-pentenal an α-(γ-L-glutamyl) acetyl-CoA CO NADH XMP 3-phospho- F1729_RS04505 (S)-3- nucleotide- [DNA] nucleobase L-cysteinylglycine deoxyfutalosine met 34 2 small phosphoribosyltransferase: hpt deaminase: methylaspartate argF dehydrogenase: dehydrogenase: -L-amino acid a [protein]- a 2-thiouridine N,N-dimethyl-1,4- CAIR dUTP dCDP kinase: pgk D-glycerate carbamoyl hydroxydodecanoyl-CoA 3'-phosphate anthranilate subunit: carA F1729_RS07620 threonine mutase: F1729_RS22950 F1729_RS22950 L-cysteine in tRNA phenylenediamine glutamine- adenylo-succinate nucleoside-diphosphate phosphate 2-oxoglutarate 2-oxoglutarate nucleoside triphosphate 13-DPG 2,3-bisphosphoglycerate- ammonia- F1729_RS09395 hydrolyzing GMP phosphoribosylaminoimidazolesuccinocarboxamide GMP pyrophosphohydrolase: kinase: F1729_RS22750 inosine independent lyase, glutamine- carbamoyl adenylosuccinate an (S-diacyl-sn- RNase III mRNA 1518 an N-terminal L- a [protein]- asp synthase: guaA synthase: F1729_RS26205 mazG phosphoglycerate (2S, 3S)-3- an L-1- adenine / (indol-3-yl) phosphate dCTP biosynthetic: hydrolyzing glutathione hydrogen selenide coenzyme A a [protein] Ser/Thr an acyl phosphate D-glucopyranose τ benzaldehyde lyase: methylaspartate phosphatidylethanolamine glyceryl)-L-cysteinyl- hypoglycin A O-acetyl-L-serine processing VibB adenine 1519 in 16S rRNA alanyl-[S5 protein acetamide N -phospho- ser purine-nucleoside mutase: ilvA carbamoyl- 3-oxododecanoyl-CoA F1729_RS04485 SAICAR dUMP (2Z)-2-aminobut- [apolipoprotein] substrate ribosomal RNA of 30S ribosome]ribosomal- serine/threonine amidase: glucose 1- L-histidine aldehyde GMP phosphorylase: F1729_RS04950 phosphate phosphohistidine threonine/serine aspartate FAD-dependent 2-enoate acetyl-CoA C- small subunit protein-alanine N- protein kinase: acylphosphatase: F1729_RS14080 dehydrogenase: dehydrogenase F1729_RS20760 cofactor- synthase glycine cleavage phosphatase dehydratase: carbamoyltransferase adenylosuccinate thymidylate acetyltransferase: apolipoprotein N- cysteine holo-[acyl- methyltransferase acetyltransferase: F1729_RS09930 F1729_RS09665 amidase: F1729_RS29185 (NADP(+)): AMP independent small gamma- ribonuclease SixA: sixA F1729_RS04505 catalytic subunit: guanylate kinase: lyase: F1729_RS04485 superpathway of 5-aminoimidazole a [glycine-cleavage synthase carrier-protein] 6 A: rsmA 1518 [+ 19 isozymes] F1729_RS15810 [+ 2 isozymes] F1729_RS12530 synthase: thyX UTP and CTP de subunit: carA F1729_RS11190 acyltransferase: lnt III: rnc N -dimethyladenine an N-terminal N-acetyl-rimI a [protein]- F1729_RS19010 hypoxanthine phosphoglycerate mesaconate 6 glutamyltransferase: ggt A: cysK synthase: acpS a [protein] (L-serine/L- a carboxylate D-glucono- F1729_RS17090 ribonucleotide biosynthesis novo biosynthesis complex H protein] N /N 6 -dimethyladenine 1519 L-alanyl-[S5 protein (indol-3-yl)acetate benzoate pyruvate AICAR dTMP mutase: 1,5-lactone L-histidine adenylate kinase: 2-iminobutanoate carbamate -[(R)-lipoyl]-L-lysine glycine cleavage system decanoyl-CoA an N-acyl-(S-diacyl- in 16S rRNA of 30S ribosome] threonine) phosphate F1729_RS10640 PRPP UMP F1729_RS29565 a 2-acyl-1-lyso- N-carbamoyl- GDP bifunctional thymidylate kinase: hypoxanthine aminomethyltransferase sn-glyceryl)-L- acetate RNase III a holo-[VibB aryl- UMP kinase: glycine cleavage system phosphatidylethanolamine hypoglycin B L-cysteinylglycine L-selenocysteine an mRNA fragment 3',5'-ADP L-aspartate phosphoribosylaminoimidazolecarboxamide amidophosphoribosyltransferase: F1729_RS00145 phosphoribosyltransferase: hpt 2-phospho- GcvT: gcvT cysteinyl-[lipoprotein] processing carrier protein] F1729_RS02705 F1729_RS11540 D-glycerate aminomethyltransferase product mRNA ADP formyltransferase/IMP cyclohydrolase: purH β dTDP UDP (S)-citramalate [+ 3 isozymes] dihydroorotase: 5-phospho- - GcvT: gcvT phosphopyruvate (2E)-dec-2-enoyl-CoA F1729_RS17095 nucleoside- ribonucleotide- FAICAR D-ribosylamine nucleoside-diphosphate nucleoside- IMP 2-oxobutanoate CO [+ 4 isozymes] ribonucleotide- hydratase: 2 a 5,10- a 2-thiouridine 34 all-trans- a 2,3,4-saturated a 2'- N-(1-phenylpropan- a [phospholipid]- a negatively a supercoiled diphosphate diphosphate phosphoribosylamine- kinase: F1729_RS22750 diphosphate citramalate L-methionine degradation a formylmethanofuran THMPT trans-aconitate 4-nitrocatecholsulfate chloroacetaldehyde an aldehyde a ribonucleoside diphosphate xanthine and F1729_RS00935 methylenetetrahydrofolate in tRNA octaprenyl 1,2-diacyl-sn- deoxyribonucleoside [DNA] 2-yl)hydroxylamine palmitoleate supercoiled DNA duplex DNA (S)-dihydroorotate kinase: reductase: bifunctional -glycine ligase: purD dTTP kinase: synthase: a [glycine-cleavage I (to L-homocysteine) 4-hydroxybenzoate 5'-monophosphate reductase: xanthosine salvage phosphopyruvate a [glycine-cleavage diphosphate glycerol 3-phosphate CTP 5'-triphosphate dimethylaniline cyclopropane-fatty- trans-aconitate 2- sulfatase: aldehyde DNA helicase SNF2: aldehyde F1729_RS22750 F1729_RS25140 phosphoribosylaminoimidazolecarboxamide F1729_RS19035 complex H protein] N 6 - 5'/3'- F1729_RS22750 hydratase: complex H protein] N 6 monooxygenase acyl-phospholipid dehydrogenase topoisomerase I: dehydrogenase dihydroorotate F1729_RS25145 F1729_RS25140 formyltransferase/IMP cyclohydrolase: purH GAR aminomethyldihydrolipoyl- (S)-3- tRNA uridine-5- formylmethanofuran-- methyltransferase: F1729_RS09710 F1729_RS17120 nucleotidase UTP F1729_RS12135 -dihydrolipoyl-L-lysine met 4-hydroxybenzoate phosphatidate polymerase: (N-oxide forming) synthase: (NADP(+)): F1729_RS23910 (NADP(+)): dehydrogenase F1729_RS25145 xanthosine propanoyl-CoA L-lysine hydroxydecanoyl-CoA carboxymethylaminomethyl(34) tetrahydromethanopterin F1729_RS15440 [+ 28 isozymes] [+ 2 isozymes] SurE: surE a metal a metal acetate pyruvate methionine octaprenyltransferase: cytidylyltransferase: F1729_RS12965 : F1729_RS10885 F1729_RS21875 (E)-3- F1729_RS12530 [+ 2 isozymes] F1729_RS12530 electron GTP IMP phosphoenol synthesis enzyme MnmG: mnmG N-formyltransferase: fhcD (E)-N-(1-phenylpropan- a [phospholipid]-8- 4-nitrocatechol a single cation cation CMP purine-nucleoside phosphate adenosyltransferase: F1729_RS04305 F1729_RS06200 [+ 9 isozymes] (methoxycarbonyl) 2-chloroacetate a relaxed DNA a carboxylate a ribonucleoside RS11475 transfer subunit: dGDP dADP pyruvate L-serine degradation 2-ylidene)hydroxylamine (2-hexylcyclopropyl) stranded DNA phosphorylation phosphorylase: propanoyltransferase: F1729_RS19080 octanoate pent-2-enedioate acetate acetate F1729_RS11395 CTP guanine and guanosine salvage F1729_RS20760 pyruvate pduL SAM a 5-aminomethyl-2- 5-formyl- nucleoside- adenine and FGAR CMP xanthine a 7,8-dihydrofolate a methanofuran dihydroorotate nucleoside- kinase: pyk 3-oxodecanoyl-CoA thiouridine 34 in tRNA tetrahydromethanopterin 4-hydroxy-3- a CDP-2,3,4-saturated- diphosphate adenosine salvage I (d)CMP kinase: propanoyl ser glycine cleavage [DNA] dehydrogenase: diphosphate phosphoribosylformylglycinamidine octaprenylbenzoate diacylglycerol kinase: F1729_RS15645 pyruvate phosphate threonine/serine system protein acetyl-CoA C- F1729_RS09525 kinase: synthase subunit guanosine F1729_RS22750 CDP dehydratase: GcvH: gcvH octanoyltransferase: PRPP F1729_RS22750 adenosine PurQ: F1729_RS10975 purine-nucleoside acetate/propionate L-threonine α orotate F1729_RS04505 F1729_RS11190 pyridin-1-ium-3-carboxylate-5- 5-amino-4- iron(III)-enterobactin RNase R degradation D-sedoheptulose a cytidine 1402 (R)-3- a [protein]-L- a [protein]- GDP- -D- nucleoside- phosphorylase: family kinase: degradation II 2-aminoprop- [+ 2 isozymes] a [LarE]-L-cysteine PRPP pimeloyl-CoA 2-hydroxyisobutyramide DNA with lesion dATP purine-nucleoside phosphoribosylformylglycinamidine pyrimidine deoxyribonucleotide phosphorylation SAH thiocarboxylate mononucleotide imidazolecarboxyamide complex substrate RNA ala 7-phosphate in 16S rRNA hydroxybutanoate D-ala proline (ω = 180) N-phospho- mannose Cell Structure Biosynthesis dGTP diphosphate F1729_RS20760 XMP F1729_RS04235 2-enoate GDP- orotate phosphorylase: synthase subunit PurL: purL octanoyl-CoA diphosphate--fructose- 16S rRNA amidase: 3-hydroxybutyrate peptidylprolyl excinuclease L-histidine F1729_RS20760 kinase: guanine thr 6-phosphate 1- (cytosine(1402)-N(4) F1729_RS14080 D-alanine--D- isomerase: phosphohistidine mannose 4,6- phosphoribosyltransferase: F1729_RS22750 dTMP dCMP propanoate L-glutamine adenosylhomocysteinase: adenine ferric enterobactin dehydrogenase: ABC: uvrA uvrB lipid IV biosynthesis (P. putida) adenine FGAM thymidylate kinase: (d)CMP kinase: L-threonine 3- ATP-dependent ribonuclease phosphotransferase: )-methyltransferase amidase: alanine ligase: F1729_RS23310 phosphatase dehydratase: A lipid IV biosynthesis (E. coli) Kdo transfer to pyrE degradation I L-glutamate F1729_RS29435 phosphoribosyltransferase: esterase: 8-amino-7- F1729_RS11200 [+ 2 isozymes] A CTP TCA cycle TCA cycle I (prokaryotic) dehydrogenase: sacrificial sulfur R: rnr F1729_RS17925 RsmH: rsmH F1729_RS28505 SixA: sixA gmd lipid IV I (E. coli) hypoxanthine F1729_RS00145 F1729_RS15645 oxononanoate an N 4 - F1729_RS15810 [+ 6 isozymes] DNA without GDP-4-dehydro- a (3R)-3- A adenine phosphoribosylformylglycinamidine F1729_RS04970 2-iminopropanoate degradation IX (via transferase LarE: larE F1729_RS26930 F1729_RS14040 D-sedoheptulose 2-hydroxy-2- acetoacetate a [protein]-L- a [protein]- a (3R)-3- phosphoribosyltransferase: hpt dTDP dCDP synthase: bioF 1402 D-alanyl-D-alanine hydroxydecanoyl- UDP-N-acetyl- orotidine 5'- cyclo-ligase: F1729_RS26725 L-2-amino-3- gln 4-aminobutanoate) L-homocysteine (2E)-oct-2-enoyl-CoA 1,7-bisphosphate methylcytidine ω lesion L-histidine α-D-rhamnose hydroxytetradecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) phosphoribosyltransferase: acetyl-CoA methylpropanoate proline ( = 0) [acp] α A phosphate nucleoside- nucleoside- oxobutanoate Asp-tRNA(Asn) in 16S rRNA -D-glucosamine α F1729_RS26930 L-glutamine pyridin-1-ium-3,5- iron(III)-[N-(2,3- N-(2,3- a nucleoside 5'- [acp] -D-glucosamine AIR diphosphate kinase: diphosphate kinase: /Glu-tRNA(Gln) glu a [LarE]-dehydroalanine AICAR a diribonucleotide orotidine-5'- GMP degradation II glycine C- bisthiocarboxylate mononucleotide dihydroxybenzoyl) dihydroxybenzoyl) monophosphate (8S)-8-amino-7- acyl-ACP--UDP-N- 3-deoxy-D-manno- F1729_RS22750 F1729_RS22750 oxaloacetate amidotransferase: glutamate coenzyme A acyl-ACP--UDP-N- phosphate AMP type II citrate synthase: acetyltransferase: -L-serine] complex -L-serine oxononanoate acetylglucosamine O- octulosonic acid pyruvate gatC gatA gatB decarboxylase: acetylglucosamine O- decarboxylase: dTTP dCTP F1729_RS02670 F1729_RS04965 (S)-3- acyltransferase: lpxA transferase: gln [+ 8 isozymes] F1729_RS01235 acyltransferase: lpxA pyrF citrate synthase: glutamate 4-aminobutanoate L-alanine hydroxyoctanoyl-CoA F1729_RS19085 gly glu pyridin-1-ium-3,5- a single- (2E,6E)-farnesyl a holo [PedD acyl- UDP-3-O-[(3R)-3- F1729_RS05890 synthase: degradation IV a [LarE]-L-cysteine glycyl-glycine glutathione cephalosporin C protoheme uroporphyrinogen-I 4-guanidinobutyramide N-ethylmaleimide 3-phenylpropionitrile Ins(2)P (S)-mandelate pyrazinamide (R)-lactate UDP-3-O-[(3R)-3- UMP dicarboxylate mononucleotide stranded RNA diphosphate carrier protein] hydroxydecanoyl]- α-Kdo-(2->6)- malate dehydrogenase: gltD gltB amidase: hydroxymyristoyl]-N- inositol mandelate amidase: D-2-hydroxyacid N-acetyl-α-D- lipid IV (E. coli) F1729_RS11355 glu ala uroporphyrinogen ACP S- F1729_RS14080 alkene reductase: nitrilase: acetyl-α-D-glucosamine A cephalosporin- monophosphatase: racemase: F1729_RS14080 dehydrogenase: glucosamine (S)-malate citrate 3-oxooctanoyl-CoA ATP-dependent gamma- polyribonucleotide protoheme IX decarboxylase: hemE malonyltransferase: amidase: F1729_RS02855 F1729_RS11315 UDP-3-O-[3- KDO transferase: alanine C deacetylase: F1729_RS23735 F1729_RS20125 [+ 2 isozymes] F1729_RS04700 UDP-3-O-[3- sacrificial sulfur glutamyltransferase: ggt nucleotidyltransferase: pnp farnesyltransferase: fabD F1729_RS15810 hydroxymyristoyl] N- F1729_RS19085 superpathway of branched chain amino acid biosynthesis Amino Acid Biosynthesis dehydrogenase: ald acetyl-CoA C- F1729_RS04785 a malonyl- pyrazine-2- hydroxymyristoyl] N- L-isoleucine L-arginine biosynthesis II (acetyl cycle) L-tryptophan biosynthesis transferase LarE: larE cyoE coproporphyrinogen I N-ethylsuccinimide 3-phenylpropanoate myo-inositol (R)-mandelate pyruvate acetylglucosamine α-Kdo-(2->4)- L-histidine biosynthesis L-proline pyruvate acetyltransferase: [PedD acyl- 4-guanidinobutanoate carboxylate acetylglucosamine biosynthesis IV biosynthesis I aconitate hydratase deacetylase: lpxC α-Kdo-(2->6)- F1729_RS11190 γ carrier protein] deacetylase: lpxC pyruvate (from L-glutamate) AcnA: acnA Inorganic Nutrient Metabolism pyridin-1-ium-3-carboxylate-5- -L-glutamyl- L-cysteinylglycine a nucleoside a single- UDP-3-O-(3- lipid IV (E. coli) thr PRPP N-acetylglutamyl-phosphate gln class II fumarate a [LarE]-dehydroalanine acetate deacetylcephalosporin C UDP-3-O-(3- A propanoate chorismate hexanoyl-CoA thiocarboxylate mononucleotide glycylglycine diphosphate stranded RNA ferroheme o hydroxymyristoyl) biosynthetic-type hydratase: F1729_RS28095 hydroxydecanoyl) -α-D-glucosamine threonine/serine propanoate:CoA glu α acetolactate ATP fumarate cis-aconitate selenate reduction - -D-glucosamine UDP-3-O-(3- ligase (AMP- assimilatory thiosulfate oxidation III urea cycle synthase large dehydratase: phosphoribosyltransferase: anthranilate synthase glutamate 5- aconitate hydratase UDP-3-O-(3- forming): acs N-acetyl- sulfate reduction IV 6 hydroxymyristoyl) (multienzyme complex) + a [protein]-N - α 7,8-dihydrofolate + a [heparan-sulfate]-2- F1729_RS04505 F1729_RS06210 component I: trpE kinase: proB succinate dehydrogenase/ AcnA: acnA NAD UDP-N-acetyl- -D-muramoyl- NADPH H a ribonucleoside a single a holo [PedN acyl- 2+ hydroxymyristoyl) subunit: ilvB propanoyl-CoA gamma-glutamyl- γ-L-glutamyl selenate D-alanyl-D-alanine MEP protoporphyrinogen IX N,N-dimethylaniline α a folate Ins(1)P ethanol a nitrile Fe glucosamine N- threonine fumarate reductase arg acetyl-L-lysine L-alanyl-γ-D-glutamyl-L-lysine monoglutamate CTP triphosphate stranded DNA carrier protein] O-sulfo- -L-iduronate glucosamine N- acyltransferase: acetolactate 1-(5-phospho-β-D-ribosyl)-ATP phosphate 5-phosphate sulfate sulfate a [SoxY protein]-L-cysteine (2E)-hexenoyl-CoA dimethylaniline iduronate- dihydrofolate catalase: bacterioferritin: bfr ammonia-lyase, 2-oxoacid:ferredoxin iron-sulfur subunit: ACP S- inositol acyltransferase: lpxD synthase small reductase: anthranilate PRPP glutamate-5- adenylyltransferase: sulfate ammonium protoporphyrinogen monooxygenase 2-sulfatase: reductase: F1729_RS20485 nitrilase: biosynthetic: ilvA oxidoreductase F1729_RS23040 NAD-dependent UDP-N-acetylmuramoyl- dihydrofolate malonyltransferase: monophosphatase: bacterioferritin: lpxD UDP-2-N,3-O-bis[(3R)- subunit: ilvN acetylglutamate F1729_RS22865 semialdehyde F1729_RS11905 adenylyltransferase: 2-C-methyl-D- DNA oxidase: hemG (N-oxide forming) F1729_RS16395 F1729_RS05975 F1729_RS11315 subunit beta: adenosine 5'- deacylase: tripeptide--D-alanyl-D- reductase: fabD F1729_RS23735 [+ 2 isozymes] F1729_RS29570 UDP-2-N-[(3R)-3- 3-hydroxytetradecanoyl]- (2Z)-2-aminobut-2-enoate kinase: argB dehydrogenase: succinate D-threo-isocitrate F1729_RS11905 argininosuccinate glutamine- erythritol 4-phosphate primase: : F1729_RS10885 anthranilate phosphoselenate F1729_RS20060 F1729_RS05975 a malonyl[PedN a [heparan sulfate]- 3+ hydroxydodecanoyl]- α (S)-2-acetolactate F1729_RS02905 gln N-acetyl-L-glutamate APS lyase: argH hydrolyzing alanine ligase: murF dnaG protoporphyrin IX N,N-dimethylaniline- a 7,8-dihydrofolate myo-inositol acetaldehyde a carboxylate Fe -D-glucosamine glu N-acetyl-L-glutamate F1729_RS22940 a [SoxY protein]-S- (S)-3- cytidylyltransferase: ispD acyl-carrier α-L-iduronate 3-O-[(3R)-3- 1-(5-phospho-β-D-ribosyl)-AMP 5-semialdehyde phosphoribosyltransferase: trpD carbamoyl- N-oxide UDP-2,3- ketol-acid 2-oxobutanoate bifunctional sulfosulfanyl-L-cysteine hydroxyhexanoyl-CoA protein] hydroxydecanoyl]- glutamate N- glutamine- N-acetylornithine L-glutamate-5- ADP-forming succinate- adenylyl-sulfate phosphate 2''-O-acetyl- UDP-N-acetyl-α-D-muramoyl-L-alanyl- 5,6,7,8- diacylglucosamine reductoisomerase: L-methionine biosynthesis III L-arginino- nicotinamide a [protein]-L-lysine NADP + 4-(cytidine 5'-diphospho) ssDNA/pppN(pN) α-D-glucosamine phosphoribosyl-AMP acetyltransferase/ hydrolyzing aminotransferase: N-(5-phosphoribosyl)-anthranilate semialdehyde -CoA ligase: sucD sucC kinase: cysC L-ornithine synthase ADP-ribose γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine tetrahydrofolate diphosphatase: ilvC biosynthetic-type bifunctional selenite cytochrome c: succinate -2-C-methyl-D-erythritol hybrid UDP-2,3- cyclohydrolase: hisI carbamoyl- F1729_RS07500 small n -1 F1729_RS16025 2-iminobutanoate acetolactate amino-acid glutamate N- PAPS F1729_RS14630 diacylglucosamine (2R)-2,3-dihydroxy- 1-(5-phospho-β-D-ribosyl)- phosphate phosphoribosylanthranilate L-homoserine subunit: carA synthase large acetyltransferase acetyltransferase/ 3-oxohexanoyl-CoA diphosphatase: lipid X 3-methylbutanoate 5-[(5-phosphoribosylamino) synthase small isomerase: F1729_RS12000 succinyl-CoA 2-oxoglutarate a 2-O-acetylated a DNA containing subunit: ilvB ArgJ: argJ amino-acid phosphoadenylyl- a [SoxY protein]-S- a [SoxY protein]-S carbamoyl 3-methyl-2- 5,10-methylene- (2R)-phospho- a [phospholipid]- (2R,3S)-3- (S)-2- F1729_RS16025 dihydroxy-acid methylideneamino]imidazole- subunit: carA (S)-1-pyrroline- homoserine O- seleno-L- a sialyloligosaccharide rhamnogalacturonan I an apurinic/ [DNA] (+)-muconolactone MeOH pyruvate prephenate lipid-A- acetolactate acetyltransferase 1-(2-carboxyphenylamino)-1- sulfate reductase: disulfanyl-L-cysteine -sulfanyl-L-cysteine phosphate acetyl-CoA C- oxobutanoate tetrahydromethanopterin 3-sulfolactate oleate isopropylmalate hydroxyglutarate dehydratase: ilvD 4-carboxamide L-lysine biosynthesis VI 5-carboxylate acetyltransferase: argininosuccinate ornithine homocysteine apyrimidinic site DNA polymerase cyclopropane-fatty- disaccharide synthase small ArgJ: argJ deoxy-D-ribulose 5-phosphate selenodiglutathione F1729_RS09495 acetyltransferase: 2-phosphosulfolactate muconate 3-isopropylmalate L-2- catalase: pyruvate prephenate lipid X (P. putida) 2-oxobutanoate 1-(5-phosphoribosyl)-5- carbamoyl phosphate L-ornithine pyrroline-5- F1729_RS06325 synthase: carbamoyltransferase: 5-methyltetrahydropteroyltriglutamate- III subunit acyl-phospholipid synthase: lpxB subunit: ilvN F1729_RS11190 3-methyl-2-oxobutanoate exo-alpha-sialidase: rhamnogalacturonan phosphatase: cycloisomerase I: dehydrogenase: hydroxyglutarate F1729_RS20485 carboxylase: dehydratase: 3-methyl-2-oxobutanoate [(5- phosphoribosylamino) N-acetyl-L-ornithine indole-3-glycerol phosphate carboxylate 2-oxoglutarate sulfite F1729_RS27205 argF - homocysteine S- gamma/tau: dnaX synthase: lipid-A- lipid A disaccharide biosynthetic-type (S)-2-aceto-2- asp synthase TrpC: trpC O-acetyl-L- L-citrulline hydroxymethyltransferase: methyltransferase: metE F1729_RS12340 acetylesterase: endonuclease F1729_RS18130 F1729_RS14135 leuB oxidase: lhgO [+ 2 isozymes] F1729_RS06090 pheA disaccharide methylideneamino]imidazole-4- reductase: homoserine hydrogen sulfide dehydrogenase butanoyl-CoA panB F1729_RS26340 [+ 3 isozymes] F1729_RS21875 4-methyl-2- 3-phenyl-2- (E. coli) acetolactate hydroxybutanoate aspartate kinase: [+ 21 isozymes] III: nth (2R)-3-sulfolactate a [phospholipid]- cis,cis-muconate 2-oxoglutarate formaldehyde oxaloacetate synthase: lpxB 2-isopropylmalate carboxamide isomerase: hisA proC E1 component: a [SoxY protein]-S-(2- a 2'-deoxyribonucleoside oxopentanoate oxopropanoate branched chain synthase large 2-aceto-2-hydroxy- F1729_RS17235 (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate SeMet dihydrosterculate lipid A tetraacyldisaccharide synthase: phosphoribulosylformimino- F1729_RS09845 glutathioselenol sulfodisulfanyl)-L-cysteine 5'-monophosphate 4'-kinase: lpxK amino acid subunit: ilvB butanoate aspartate kinase: pro assimilatory a rhamnogalacturonan disaccharide F1729_RS10970 AICAR-phosphate N-acetylneuraminate an oligosaccharide acetate a 3'-terminal a 5'-phospho- aminotransferase: acetolactate isomeroreductase: ornithine F1729_RS20615 tryptophan synthase: hydrogen sulfide sulfate reduction III 2-dehydropantoate THMPT type I (P. putida) lipid IV (E. coli) 2-isopropylmalate F1729_RS27935 ilvE L-aspartyl- 2-aminoethylphosphonate unsaturated sugar [DNA] A synthase small ilvC carbamoyltransferase: trpB F1729_RS26130 crotonyl-CoA tetraacyldisaccharide synthase: branched chain imidazole glycerol argF 4-phosphate L-homocysteine sulfate degradation I subunit: ilvN (R)-2,3-dihydroxy- ser 4'-kinase: lpxK F1729_RS09555 amino acid phosphate synthase indole sulfate (S)-2-aceto-2- 3-methylpentanoate aspartate- hydrogen selenide methylphosphonate (2-aminoethyl) 5-formyl- (R)-4'- DNA combined with a 3-O-acetylated a cytosine 967 (2R,3S)-3- (indole-3-yl) lipid IV subunit HisF: hisF adenylyltransferase: a methanofuran a formylmethanofuran uroporphyrinogen-III a [protein] (L-serine/L- a double stranded DNA nitric oxide acetamide NADH A aminotransferase: 5-methyltetrahydropteroyltriglutamate- degradation III phosphopantothenoyl- exogenous DNA to form rhamnogalacturonan I hydroxybutanoate dihydroxy-acid semialdehyde polyphosphate F1729_RS11905 phosphonate2-aminoethylphosphonate- tetrahydrosarcinapterin in 16S rRNA threonine) phosphate isopropylmalate acetonitrile (P. putida) F1729_RS09330 imidazole glycerol methionine - homocysteine S- sulfate activation (S)-3- L-cysteine a recombinational junction formylmethanofuran 16S rRNA (2S)-2-isopropylmalate ketol-acid dehydratase: ilvD dehydrogenase: tryptophan synthase: metabolism APS -pyruvate Holliday junction uroporphyrinogen-III serine/threonine DNA gyrase 3-isopropylmalate NO-inducible acetamidase: NAD(+)/ phosphate synthase synthase: methyltransferase: metE for sulfonation methylphosphonate hydroxybutanoyl-CoA dehydrogenase subunit (cytosine(967)-C(5) nitrilase: reductoisomerase: F1729_RS18140 trpB F1729_RS26130 metH transaminase: phnW formylmethanofuran-- phosphopantothenoylcysteine resolvase RuvX: ruvX rhamnogalacturonan C-methyltransferase: phosphatase: subunit A: gyrA dehydratase: flavohemoprotein: F1729_RS13045 NADH kinase: 3-isopropylmalate subunit HisH: hisH (3S)-3-methyl-2- methionine long chain phosphoadenylyl- A: F1729_RS10230 )-methyltransferase F1729_RS11315 val ilvC L-citrulline L-aspartate 4- sulfate phosphonoacetaldehyde tetrahydromethanopterin decarboxylase: F1729_RS19020 crossover junction acetylesterase: cobA F1729_RS25305 [+ 3 isozymes] leuD leuC hmpA [+ 2 isozymes] F1729_RS14970 dehydratase: oxopentanoate synthase: polyphosphate sulfate reductase: formylmethanofuran RsmB: rsmB (R)-2,3-dihydroxy- sulfate endodeoxyribonuclease F1729_RS26340 967 a negatively (2S)-2- leuD leuC semialdehyde trp (hydroxymethyl) N-formyltransferase: fhcD precorrin-2 a 5-methylcytosine a [protein] Ser/Thr (indol-3-yl)acetate nitrate acetate NADPH sulfate RS06785 sulfate 3-methylpentanoate AICAR D-erythro-1-(imidazol-4- branched chain L-homoserine metH adenylyltransferase: F1729_RS09495 phosphonoacetaldehyde 4'-phosphopantetheine RuvC: ruvC dehydrogenase subunit supercoiled DNA isopropylmalate amino acid argininosuccinate dihydrodipicolinate phosphonate resolution of recombinational in 16S rRNA 2-isopropylmaleate yl)-glycerol 3-phosphate biosynthesis superpathway of L-serine F1729_RS11905 hydrolase: F1729_RS28400 acetoacetyl-CoA a rhamnogalacturonan C: F1729_RS19130 dihydroxy-acid aminotransferase: synthase: synthetase: met polyphosphate sulfite junction formation imidazoleglycerol- F1729_RS27205 and glycine biosynthesis I APS tetrahydrosarcinapterin a formylmethanofuran of two intact strands acetate type I a methanofuran 3-isopropylmalate dehydratase: ilvD F1729_RS27935 ilvE F1729_RS11270 kinase 1: ppk1 acetaldehyde acetyl-CoA C- phosphate (2S,4S)-4- asp 3-phospho- acetyltransferase: dehydratase: (3S)-3-methyl-2- branched chain L-arginino-succinate polyphosphate adenylyl-sulfate sulfate RS07510 sulfate dehydratase hydroxy-2,3,4,5- aspartate kinase: D-glycerate formate acetaldehyde F1729_RS11190 leuD leuC oxopentanoate HisB: hisB amino acid F1729_RS17235 phosphoglycerate kinase 2: ppk2 kinase: cysC (1R,6R)-6-hydroxy-2- α tetrahydrodipicolinate dehydrogenase: a generic phosphatidylglycerolphosphate a 5-carboxymethylaminomethyluridine 34 D-threo-7,8- a single dTDP-4-amino-4,6- a uridine 55 2-hydroxy-2- (S)-4- a 2-O-sulfo- - CTP branched chain aminotransferase: argininosuccinate dehydrogenase: succinylcyclohexa-2,4- an aryl sulfate citrate (2R,3S)-3-isopropylmalate 3-(imidazol-4-yl)-2- 4-hydroxy- aspartate kinase: hydrogen sulfide F1729_RS04220 acetyl-CoA polynucleotide substrate in tRNA Leu dihydroneopterin stranded DNA dideoxy-α-D-galactose in tRNA methylpropanenitrile hydroxymandelate L-iduronate F1729_RS09330 lyase: argH F1729_RS27725 PAPS (1-oleoyl, 2-palmitoyl) amino acid oxopropyl phosphate tetrahydrodipicolinate F1729_RS20615 glycine biosynthesis II long chain tRNA (cytidine(34) dTDP-4-amino-4,6- diene-1-carboxylate tRNA mandelate in [dermatan] sulfatase: dCTP deaminase: aconitate L-aspartyl- deoxyribonuclease nitrilase: iduronate- 3-isopropylmalate aminotransferase: reductase: phosphoglycerate polyphosphate acetyl-CoA phosphatidylglycerophosphatase -2'-O)- dideoxygalactose o-succinylbenzoate pseudouridine(55) racemase: F1729_RS09710 F1729_RS02910 hydratase dehydrogenase: F1729_RS27935 ilvE histidinol-phosphate ile arg 4-phosphate dehydrogenase: a [glycine-cleavage glyphosate S1/P1 nuclease: A: F1729_RS09565 methyltransferase: dihydroneopterin IV: F1729_RS09715 F1729_RS11315 2-sulfatase: F1729_RS26845 6 transaminase: rffA synthase: menC synthase TruB: truB F1729_RS20125 [+ 28 isozymes] AcnA: acnA transaminase: hisC complex H protein] N - degradation II F1729_RS16395 UTP leuB F1729_RS27290 F1729_RS12265 F1729_RS17960 aldolase: folB dTDP-4-dehydro-6- 55 α branched chain (S)-2,3,4,5- aspartate- aminomethyldihydrolipoyl- 1-oleoyl-2-palmitoyl- a pseudouridine 2-hydroxy-2- (R)-4- an -L-iduronate L-cysteine biosynthesis I 3-phosphooxypyruvate a 5-carboxymethylaminomethyl- a 5'-phosphooligonucleotide deoxy-α-D-glucopyranose 2-succinylbenzoate a phenol D-threo-isocitrate (2S)-2-isopropyl- amino acid ammonia tetrahydrodipicolinate semialdehyde 34 Leu in tRNA methylpropanoate hydroxymandelate in [dermatan] L-histidinol phosphate L-lysine glyphosate phosphatidylglycerol 2'-O-methyluridine in tRNA 3-oxosuccinate aminotransferase: assimilation cycle III LL-diaminopimelate dehydrogenase: 3-phosphoserine/ glycine cleavage glycine cleavage systemgly 6-(hydroxymethyl) glycolaldehyde F1729_RS09330 ser aminotransferase: F1729_RS18140 phosphohydroxythreonine aminomethyltransferase a 5'-phosphomononucleotide a 5'-phosphooligonucleotide system protein glycine -7,8-dihydropterin ammonium glu F1729_RS29390 L-aspartate 4- transaminase: serC GcvT: gcvT ile serine GcvH: gcvH oxidase L,L- semialdehyde O-phospho- [+ 2 isozymes] [+ 3 isozymes] ThiO: thiO 2,5-diamino-6-(5- an [amino-group carrier protein]- 4-methyl-2-oxopentanoate acetyltransferase: 5,10-methenyl- 4a-hydroxy-N 10 - 2'-deoxycytidine a uridine 13 N-acetyl-D- L-gulono- dCTP uracil degradation histidinol diaminopimelate homoserine L-serine a [glycine-cleavage a [glycine-cleavage phospho-D-ribitylamino) C-terminal-γ-(L-glutamate 5- uroporphyrinogen-III oxaloacetate L-rhamnulofuranose cellulose D-glucopyranose F1729_RS12925 glutamine 6 6 tetrahydrosarcinapterin formyltetrahydrofolate in tRNA mannosamine 1,4-lactone dehydrogenase: complex H protein] N complex H protein] N nucleoside deaminase: branched chain I (reductive) serine synthetase: diaminopimelate (aminomethyl) pyrimidin-4(3H)-one semialdehyde-2-yl)-L-glutamateN-acetyl-gamma- tRNA dCTP deaminase: xylose histidinol F1729_RS27300 -dihydrolipoyl-L-lysine -[(R)-lipoyl]-L-lysine glyoxylate bifunctional methenyltetrahydromethanopterin 4a-hydroxytetrahydrobiopterin uroporphyrinogen F1729_RS02810 citrate synthase: N-acetylneuraminate rhamnulokinase: Endoglucanase Y: gluconolactonase: amino acid uracil acetyltransferase: F1729_RS25750 epimerase: phosphonate glutamyl-phosphate pseudouridine(13) F1729_RS02910 isomerase: dehydrogenase: hisD diaminohydroxyphosphoribosylaminopyrimidine cyclohydrolase: F1729_RS23330 dehydratase: F1729_RS17775 decarboxylase: hemE nucleoside deaminase: F1729_RS05890 synthase: neuB rhaB F1729_RS08800 F1729_RS28085 aminotransferase: L-threonine F1729_RS02010 [+ 3 isozymes] F1729_RS01555 reductase: synthase TruD: truD xylA L-homoserine deaminase/5-amino-6-(5-phosphoribosylamino) F1729_RS06185 β dUTP F1729_RS27935 ilvE 10 13 N-acetyl- - biosynthesis histidinal meso- uracil reductase RibD: ribD 5-formyl- an N -formyl- an [amino-group carrierF1729_RS22865 protein]- a pseudouridine 1,2-dihydroxypropane- L-rhamnulose a cellodextrin keto-D-fructose ser 5-amino-6-(5-phospho- coproporphyrinogen III 2'-deoxyuridine neuraminate L-gulonate branched chain O-acetyl-L-serine hydrogen sulfide diaminopimelate tetrahydrosarcinapterin 7,8-dihydrofolate C-terminal-γ-(5-phospho- in tRNA 1,2,3-tricarboxylate 1-phosphate 5,6-dihydrouracil D-ribitylamino)uracil amino acid L-homoserine histidinol gln serine glycine cleavage system L-glutamyl)-L-glutamate aminotransferase: hydantoinase: dehydrogenase: hisD diaminopimelate hydroxymethyltransferase: aminomethyltransferase F1729_RS09330 cysteine glutamate decarboxylase: lysA GcvT: gcvT F1729_RS23305 synthase: superpathway of L- F1729_RS18205 O-phospho- his synthase A: cysK [+ 4 isozymes] gltD gltB asparagine biosynthesis leu L-homoserine 3-ureidopropanoate lys gly L-glutamate threonine cys glu asp biosynthesis III synthase: thrC L-alanine threonine 2-oxoglutarate biosynthesis III L-glutamate asparagine asparagine synthase: β-alanine β-alanine glutamate biosynthesis II glycine synthase synthase F1729_RS20715 biosynthesis III synthase: cys biosynthesis IV (glutamine- (glutamine- gltD gltB cysteine 2-oxoglutarate thr hydrolyzing) hydrolyzing) asp desulfurase: glutamate thr glutamate dehydrogenase: : asnB : asnB aspartate 1- dehydrogenase: F1729_RS27890 low-specificity F1729_RS22950 [+ 2 isozymes] [+ 2 isozymes] decarboxylase: F1729_RS22950 cysteine L-threonine glu F1729_RS18940 glu desulfurase: sufS aldolase: ltaE β-alanine ala gly asn asn

a reduced a reduced a reduced a reduced plastocyanin plastocyanin plastocyanin plastocyanin an oxidized an oxidized an oxidized a sugar 6- an oxidized a C4- a C4- an inorganic an inorganic sodium D-fructose a quaternary molybdate a tricarboxylate a nucleoside plastocyanin plastocyanin plastocyanin ammonium a dipeptide phosphate plastocyanin dicarboxylate dicarboxylate anion anion bicarbonate 1-phosphate D-gluconate ammonium a lipopolysaccharide compound

cytochrome cytochrome cytochrome ModA RS26020 RS27055 RS26245 CoxB RS06545 RS24730 RS05695 RS03255 RS21165 RS23540 RS06885 LptB SugE Amt RS14420 c oxidase c oxidase c oxidase

a C4- a C4- an inorganic an inorganic sodium molybdate a tricarboxylate a sugar a nucleoside D-fructose D-gluconate a quaternary ammonium a dipeptide O dicarboxylate dicarboxylate anion anion bicarbonate a lipopolysaccharide 2 O O O ammonium H O 2 2 2 compound 2 H O H O H O 2 2 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.