HIST1H2BG, NT (HIST1H2BC, H2BFL, H2B type 1-C/E/F/G/I, Histone H2B.1 A, Histone H2B.a, Histone H2B.g, Histone H2B.h, Histone H2B.k, Histone H2B.l) (Biotin)

Catalog number 036594-Biotin Supplier United States Biological

Histones are basic nuclear that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on 6. [provided by RefSeq]. Applications Suitable for use in Western Blot, ELISA Recommended Dilution ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note Applications are based on unconjugated antibody. Immunogen HIST1H2BG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BG. Formulation Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin. Purity Purified by A affinity chromatography. Specificity Human Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications E WB Crossreactivity Hu Storage -20°C Detection Method Biotin Reference Kim, S.C., et al. Mol. Cell 23(4):607-618(2006) Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006) Pavri, R., et al. Cell 125(4):703-717(2006) Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006) Zhu, B., et al. Mol. Cell 20(4):601-611(2005)

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