Rodenticides
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
“Baits and Baiting Strategies for Multi-Species Pest Control and Feral
Baits and baiting strategies for multi-species pest control and feral cats SCIENCE FOR CONSERVATION: 40 D.R. Morgan, J. Innes, C. Ryan, L. Meikle Published by Department of Conservation P.O. Box 10-420 Wellington, New Zealand 1 Science for Conservation presents the results of investigations contracted to science providers outside the Department of Conservation. Reports are subject to peer review within the Department and, in some instances, to a review from outside both the Department and the science providers. November 1996, Department of Conservation ISSN 1173-2946 ISBN 0-478-01855-X This publication originated from work done under Department of Conservation contract 1748 carried out by D.R. Morgan, J. Innes and C. Ryan, Manaaki Whenua – Landcare Research, P.O. Box 69, Lincoln; and contract 617, carried out by D.R. Morgan and L. Meikle, Manaaki Whenua – Landcare Research, P.O. box 31-011, Christchurch. It was approved for publication by the Director, Science and Research Division, Department of Conservation, Wellington. Cataloguing-in-Publication data Baits and baiting strategies for multi-species pest control and feral cats / D.R. Morgan ... {et al.} Wellington, N.Z. : Dept. of Conservation, 1996. 1 v. ; 30 cm. (Science for conservation, 1173-2946 ; 40.) Includes bibliographical references. ISBN 047801855X 1. Pests- -Control- -New Zealand. I. Morgan, D.R. (David Rowland), 1950- II. Series: Science for conservation (Wellington, N.Z.) ; 40. 632.9510993 20 zbn96-124202 2 CONTENTS PART 1: DEVELOPMENT OF MULTI-SPECIES BAITING (D.R. Morgan, J. Innes, C. Ryan) Abstract 5 1. Introduction 5 2. Background 6 3. Objectives 6 4. -
The Persistence and Secondary Poisoning Risks of Sodium Monofluoroacetate (1080), Brodifacoum, and Cholecalciferol in Possums
THE PERSISTENCE AND SECONDARY POISONING RISKS OF SODIUM MONOFLUOROACETATE (1080), BRODIFACOUM, AND CHOLECALCIFEROL IN POSSUMS C. T. EASON, G. R. WRIGHT, and L. MEIKLE, Manaaki Whenua - Landcare Research, P.O. Box 69, Lincoln, New Zealand. P. ELDER, Steroid and Immunobiochemistry Unit, Christchurch Health Laboratories, Christchurch Hospital, P.O. Box 151, Christchurch, New Zealand. ABSTRACT: To determine the risk of secondary poisoning for animals preying on sub-lethally poisoned brushtail possums, captive possums were treated with near-lethal doses of sodium monofluoroacetate (1080) or brodifacoum, and toxicant concentrations in blood and tissue were monitored over time. Sodium monofluoroacetate was rapidly eliminated from the blood (within three days). Brodifacoum was retained in the liver and, to a lesser extent, the muscle of possums for eight months after dosing. To determine the potential risk for animals scavenging on the carcasses of possums poisoned with cholecalciferol, cats were fed poisoned carcasses for six days. No changes in behavior, appetite, or body weight were observed. Serum calcium concentrations increased slightly, but remained within the normal range for cats. KEY WORDS: vertebrate pest control, secondary poisoning, sodium monofluoroacetate, brodifacown, cholecalciferol Proc. 17th Yertebr. Pest Conf. (R.M. Timm & A.C. Crabb, Eds.) Published at Univ. of Calif., Davis. 1996. INTRODUCTION 1995), and toxic amounts of brodifacoum may be retained Sodium monofluoroacetate (1080) has been used for in a carcass. vertebrate pest control in New Zealand since 1954. It is The existence of an effective antidote to brodifacoum currently used most frequently in aerially sown baits and in the form of vitamin Kl means that dogs that have eaten in baits in bait stations for the control of the Australian carcasses containing brodifacoum residues can usually be brushtail possum (Trichosurus vulpecula) (Livingstone saved. -
First Evidence of Anticoagulant Rodenticides in Fish in German
Environmental Science and Pollution Research https://doi.org/10.1007/s11356-018-1385-8 ADVANCEMENTS IN CHEMICAL METHODS FOR ENVIRONMENTAL RESEARCH First evidence of anticoagulant rodenticides in fish and suspended particulate matter: spatial and temporal distribution in German freshwater aquatic systems Matthias Kotthoff1 & Heinz Rüdel2 & Heinrich Jürling1 & Kevin Severin1 & Stephan Hennecke1 & Anton Friesen3 & Jan Koschorreck3 Received: 27 September 2017 /Accepted: 24 January 2018 # The Author(s) 2018. This article is an open access publication Abstract Anticoagulant rodenticides (ARs) have been used for decades for rodent control worldwide. Research on the exposure of the environment and accumulation of these active substances in biota has been focused on terrestrial food webs, but few data are available on the impact of ARs on aquatic systems and water organisms. To fill this gap, we analyzed liver samples of bream (Abramis brama) and co-located suspended particulate matter (SPM) from the German Environmental Specimen Bank (ESB). An appropriate method was developed for the determination of eight different ARs, including first- and second-generation ARs, in fish liver and SPM. Applying this method to bream liver samples from 17 and 18 sampling locations of the years 2011 and 2015, respectively, five ARs were found at levels above limits of quantifications (LOQs, 0.2 to 2 μgkg−1). For 2015, brodifacoum was detected in 88% of the samples with a maximum concentration of 12.5 μgkg−1. Moreover, difenacoum, bromadiolone, difethialone, and flocoumafen were detected in some samples above LOQ. In contrast, no first generation AR was detected in the ESB samples. In SPM, only bromadiolone could be detected in 56% of the samples at levels up to 9.24 μgkg−1.A temporal trend analysis of bream liver from two sampling locations over a period of up to 23 years revealed a significant trend for brodifacoum at one of the sampling locations. -
Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-Target Organisms Katherine Horak U.S
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln USDA National Wildlife Research Center - Staff U.S. Department of Agriculture: Animal and Plant Publications Health Inspection Service 2018 Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms Katherine Horak U.S. Department of Agriculture, [email protected] Penny M. Fisher Landcare Research Brian M. Hopkins Landcare Research Follow this and additional works at: https://digitalcommons.unl.edu/icwdm_usdanwrc Part of the Life Sciences Commons Horak, Katherine; Fisher, Penny M.; and Hopkins, Brian M., "Pharmacokinetics of Anticoagulant Rodenticides in Target and Non- target Organisms" (2018). USDA National Wildlife Research Center - Staff Publications. 2091. https://digitalcommons.unl.edu/icwdm_usdanwrc/2091 This Article is brought to you for free and open access by the U.S. Department of Agriculture: Animal and Plant Health Inspection Service at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in USDA National Wildlife Research Center - Staff ubP lications by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Chapter 4 Pharmacokinetics of Anticoagulant Rodenticides in Target and Non-target Organisms Katherine E. Horak, Penny M. Fisher, and Brian Hopkins 1 Introduction The concentration of a compound at the site of action is a determinant of its toxicity. This principle is affected by a variety of factors including the chemical properties of the compound (pKa, lipophilicity, molecular size), receptor binding affinity, route of exposure, and physiological properties of the organism. Many compounds have to undergo chemical changes, biotransformation, into more toxic or less toxic forms. Because of all of these variables, predicting toxic effects and performing risk assess- ments of compounds based solely on dose are less accurate than those that include data on absorption, distribution, metabolism (biotransformation), and excretion of the compound. -
Veterinary Toxicology
GINTARAS DAUNORAS VETERINARY TOXICOLOGY Lecture notes and classes works Study kit for LUHS Veterinary Faculty Foreign Students LSMU LEIDYBOS NAMAI, KAUNAS 2012 Lietuvos sveikatos moksl ų universitetas Veterinarijos akademija Neužkre čiam ųjų lig ų katedra Gintaras Daunoras VETERINARIN Ė TOKSIKOLOGIJA Paskait ų konspektai ir praktikos darb ų aprašai Mokomoji knyga LSMU Veterinarijos fakulteto užsienio studentams LSMU LEIDYBOS NAMAI, KAUNAS 2012 UDK Dau Apsvarstyta: LSMU VA Veterinarijos fakulteto Neužkre čiam ųjų lig ų katedros pos ėdyje, 2012 m. rugs ėjo 20 d., protokolo Nr. 01 LSMU VA Veterinarijos fakulteto tarybos pos ėdyje, 2012 m. rugs ėjo 28 d., protokolo Nr. 08 Recenzavo: doc. dr. Alius Pockevi čius LSMU VA Užkre čiam ųjų lig ų katedra dr. Aidas Grigonis LSMU VA Neužkre čiam ųjų lig ų katedra CONTENTS Introduction ……………………………………………………………………………………… 7 SECTION I. Lecture notes ………………………………………………………………………. 8 1. GENERAL VETERINARY TOXICOLOGY ……….……………………………………….. 8 1.1. Veterinary toxicology aims and tasks ……………………………………………………... 8 1.2. EC and Lithuanian legal documents for hazardous substances and pollution ……………. 11 1.3. Classification of poisons ……………………………………………………………………. 12 1.4. Chemicals classification and labelling ……………………………………………………… 14 2. Toxicokinetics ………………………………………………………………………...………. 15 2.2. Migration of substances through biological membranes …………………………………… 15 2.3. ADME notion ………………………………………………………………………………. 15 2.4. Possibilities of poisons entering into an animal body and methods of absorption ……… 16 2.5. Poison distribution -
The Veterinarian's Guide
The Veterinarian’s Guide Bromethalin Addendum The Soft Bait Innovators™ Liphatech, Inc. • 3600 W. Elm Street • Milwaukee, WI 53209 • 1-888-331-7900 • www.liphatech.com NOTE: The information in this guide does not represent labeling and does not replace information on rodenticide labels relating to exposure of non-target species. Please read and follow all label directions on all rodenticide products you are using. Mentions of trade names in this publication does not imply endorsement of these products. Assault® is a registered trademark of PM Resources (St. Louis, MO) TakeDown™ and Cannon™ are trademarks of Liphatech, Inc. (Milwaukee, WI) Gunslinger® is a registered trademark of Liphatech, Inc. (Milwaukee, WI) Fastrac® is a registered trademark of Bell Labs (Madison, WI) Top Gun™ is a trademark of JT Eaton (Twinsburg, OH) Tomcat® and Rampage® are registered trademarks of Motomco (Madison, WI) Trounce® is a registered trademark of Agricultural Feeds (St. Louis, MO) At the time of this printing all information was deemed accurate and reliable. Liphatech, Inc. 3600 W. Elm Street Milwaukee, WI 53209 1-888-331-7900 www.liphatech.com October, 2016 The Veterinarian’s Guide - Bromethalin Addendum The Veterinarian’s Guide to Accidental Rodenticide Ingestion by Dogs and Cats focuses on anticoagulants. This addendum is intended to help veterinarians recognize and treat the symptoms of bromethalin toxicity in domestic animals. It describes bromethalin’s mode of action and how it is used as a rodenticide. In addition to reviewing the symptoms of bromethalin poisoning in domestic animals and the acute toxicity levels for dogs and cats (Table 5), we have also included the American Society for Prevention of Cruelty to Animals’ Animal Poison Control Center (ASPCA APCC) recommendations for decontamination (Tables 6 and 7). -
The Evaluation of Alternative Toxins to Sodium Monofluoroacetate (1080) for Possum Control
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by UNL | Libraries University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Proceedings of the Fifteenth Vertebrate Pest Vertebrate Pest Conference Proceedings Conference 1992 collection March 1992 THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL Charles T. Eason Forest Research Institute, P.O. Box 31-011, Christchurch, New Zealand Follow this and additional works at: https://digitalcommons.unl.edu/vpc15 Part of the Environmental Health and Protection Commons Eason, Charles T., "THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL" (1992). Proceedings of the Fifteenth Vertebrate Pest Conference 1992. 24. https://digitalcommons.unl.edu/vpc15/24 This Article is brought to you for free and open access by the Vertebrate Pest Conference Proceedings collection at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Proceedings of the Fifteenth Vertebrate Pest Conference 1992 by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. THE EVALUATION OF ALTERNATIVE TOXINS TO SODIUM MONOFLUOROACETATE (1080) FOR POSSUM CONTROL CHARLES T. EASON, Forest Research Institute, P.O. Box 31-011, Christchurch, New Zealand ABSTRACT: Possum control in New Zealand is dependent on the use of sodium monofluroacetate (1080) and cyanide. Although 1080 is highly effective, its use is restricted to government staff. Cyanide is available for a wider group of licensed operators, but cyanide "shyness" reduces its effectiveness. An acute toxicity programme has been set up to identify non- anticoagulant toxins that could be used safely by farmers. Dose-ranging studies showed that possums are susceptible to cholecalciferol, calciferol, gliftor, alpha-chloralose, and nicotine, but not to bromethalin. -
Bromethalin Ingestion
PEEER REVR IEWEWED PRACTICAL TOXICOLOGY The Decontamination Dilemma: Bromethalin Ingestion Renee Tourdot, DVM, ASPCA Animal Poison Control Center shutterstock.com/Ysbrand Cosijn Bromethalin-based rodenticide bait exposures have become increasingly common since the Welcome to Practical Toxicology, brought to you in 1 partnership between Today’s Veterinary Practice and product became available in 1985. In 2015, the ASPCA Animal Poison Control Center (APCC) the American Society for the Prevention of (www.aspcapro.org/poison). This column provides practical clinical information about diagnosing and Cruelty to Animals Animal Poison Control treating pets that have been exposed to potentially Center received 2791 calls regarding exposures harmful substances. to bromethalin-based rodenticides.2 The APCC: • Provides 24-hour diagnostic and treatment Exposures to this toxin present a unique challenge recommendations by specially trained veterinary to clinicians. Once signs of convulsant syndrome—a toxicologists neurologic syndrome caused by bromethalin • Protects and improves animal lives through toxicology toxicosis—have developed, prognosis for recovery is education, consulting services, and case data review poor.3,4 Therefore, most clinicians seem aware that • Developed and maintains AnTox, an animal toxicology database system that identifies and characterizes prompt and aggressive decontamination measures toxic effects of substances in animals must be taken. However, if decontamination • Works closely with human poison control centers to is too aggressive, iatrogenic hypernatremia can provide animal poisoning information develop, and clinical hypernatremia can be just as • Offers extensive veterinary life-threatening as a large bromethalin exposure. toxicology consulting to organizations in industry, government, and agriculture. To further complicate matters, clinical signs of hypernatremia can appear similar to the neurologic If treating a patient that 5 requires emergency care for signs caused by bromethalin. -
RRAC Guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of Croplife International Aim
RRAC guidelines on Anticoagulant Rodenticide Resistance Management Editor: Rodenticide Resistance Action Committee (RRAC) of CropLife International Aim This document provides guidance to advisors, national authorities, professionals, practitioners and others on the nature of anticoagulant resistance in rodents, the identification of anticoagulant resistance, strategies for rodenticide application that will avoid the development of resistance and the management of resistance where it occurs. The Rodenticide Resistance Action Committee (RRAC) is a working group within the framework of CropLife International. Participating companies include: Bayer CropScience, BASF, LiphaTech S. A., PelGar, Rentokil Initial, Syngenta and Zapi. Senior technical specialists, with specific expertise in rodenticides, represent their companies on this committee. The RRAC is grateful to the following co-authors: Stefan Endepols, Alan Buckle, Charlie Eason, Hans-Joachim Pelz, Adrian Meyer, Philippe Berny, Kristof Baert and Colin Prescott. Photos provided by Stefan Endepols. Contents 1. Introduction ............................................................................................................................................................................................................. 2 2. Classification and history of rodenticide compounds ..............................................................................................3 3. Mode of action of anticoagulant rodenticides, resistance mechanisms, and resistance mutations ......................................................................................................6 -
Question of the Day Archives: Monday, December 5, 2016 Question: Calcium Oxalate Is a Widespread Toxin Found in Many Species of Plants
Question Of the Day Archives: Monday, December 5, 2016 Question: Calcium oxalate is a widespread toxin found in many species of plants. What is the needle shaped crystal containing calcium oxalate called and what is the compilation of these structures known as? Answer: The needle shaped plant-based crystals containing calcium oxalate are known as raphides. A compilation of raphides forms the structure known as an idioblast. (Lim CS et al. Atlas of select poisonous plants and mushrooms. 2016 Disease-a-Month 62(3):37-66) Friday, December 2, 2016 Question: Which oral chelating agent has been reported to cause transient increases in plasma ALT activity in some patients as well as rare instances of mucocutaneous skin reactions? Answer: Orally administered dimercaptosuccinic acid (DMSA) has been reported to cause transient increases in ALT activity as well as rare instances of mucocutaneous skin reactions. (Bradberry S et al. Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning. 2009 Q J Med 102:721-732) Thursday, December 1, 2016 Question: What is Clioquinol and why was it withdrawn from the market during the 1970s? Answer: According to the cited reference, “Between the 1950s and 1970s Clioquinol was used to treat and prevent intestinal parasitic disease [intestinal amebiasis].” “In the early 1970s Clioquinol was withdrawn from the market as an oral agent due to an association with sub-acute myelo-optic neuropathy (SMON) in Japanese patients. SMON is a syndrome that involves sensory and motor disturbances in the lower limbs as well as visual changes that are due to symmetrical demyelination of the lateral and posterior funiculi of the spinal cord, optic nerve, and peripheral nerves. -
Justification for the Renewal of the Approvals for the Anticoagulant
Justification for the renewal of the approvals for the anticoagulant rodenticides brodifacoum, bromadiolone, chlorophacinone, coumatetralyl, difenacoum, difethialone, flocoumafen and warfarin Rodent control is essential, and in many cases a legal requirement, to prevent disease transmission, consumption and contamination of food and feedingstuffs, structural damage and to remove social abhorrence. Currently, the anticoagulant rodenticides (also referred to as AVKs) are the dominant and most effective substances for rodent control. Therefore, the current AVK active substances approved for PT 14 will continue to be essential for efficient and effective rodent control in order to maintain good public hygiene and protect public health. The original evaluations for first approval at EU level recognised the need of the AVKs. The corresponding Assessment Reports for the AVKs acknowledged this when they concluded that: According to the Annex I inclusion criteria referred to in Article 10 of the Directive and TNsG on Annex I inclusion, AVKs should not be included in Annex I. However, in the decision making also benefits of using the active substance in the biocidal products have to be considered (Paragraph 96 in Annex VI of the Directive). It is concluded that AVKs are needed as rodenticides for human hygiene and public health reasons. In this exceptional case the benefit should take precedence over the risks and AVKs should be included in Annex I. [The text above is a generalised extract based on the conclusions of the Assessment Reports of the AVKs] All of the AVKs meet one of the exclusion criteria under Article 5(1) of the Biocidal Products Regulation (BPR), which prohibits their approval unless one or more of the derogations provided for in Article 5(2) are met. -
Final Soft Bait Singapore Date Created: March 2017 Supplier: Bell Laboratories, Inc
FINAL®SOFT BAIT SAFETY DATA SHEET ACCORDING TO REGULATION: Section 274 of DATE OF ISSUE: PREPARED BY: the Work Health and Safety Act March 2017 CAR SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product Identifier: FINAL® SOFT BAIT Relevant identified uses: Anticoagulant Rodenticide - Ready to use Uses advised against: Use only for the purpose described above MANUFACTURER: IMPORTER: EMERGENCY PHONE NUMBERS: Bell Laboratories, Inc. Bentz Jaz Singapore Pte Ltd Consult the local/regional poison control 3699 Kinsman Blvd. 48 Toh Guan Road East, center. Madison, WI 53704, USA Enterprise Hub #06-139 email: [email protected] Singapore 608586 t +65 6841 2986 I f +65 6841 2026 www.bentzjaz.com.sg SECTION 2. HAZARDS IDENTIFICATION THIS PRODUCT IS CLASSIFIED AS: NOT HAZARDOUS ACCORDING TO THE CRITERIA OF SWA. NOT A DANGEROUS GOOD ACCORDING TO AUSTRALIAN DANGEROUS GOODS (ADG) CODE, IATA OR IMDG/IMSBC CRITERIA. SUSMP Classification: S6 ADG Classification: None allocated. Not a Dangerous Good according to Australian Dangerous Goods (ADG) Code, IATA or IMDG/IMSBC criteria. UN Number: None allocated GHS Signal word: WARNING HAZARD STATEMENT: H373: May cause damage to organs through prolonged or repeated exposure. PREVENTION P102: Keep out of reach of children. P264: Wash contacted areas thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P273: Avoid release to the environment. RESPONSE P313: Get medical attention/advice P321: Treatment with Vitamin K, which is antidotal, is almost always successful P337: If eye irritation persists: seek medical attention P353: Rinse skin or shower with water. P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.