Monthly Healthcare Review January 2017 IPOs The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

Last Last Financing Financing Company Name HQ Location Description Lead Manager Date Size (Millions)

Jounce Therapeutics Developer of cancer immunotherapies designed to match the right therapy to the right patients Cowen and Company, (JNCE) 27-Jan-2017 Cambridge, MA enabling the immune system to attack tumors and provide long-lasting benefits to patients. 104.00 J.P. Morgan Securities Credit Suisse Geneva, Securities, Jefferies, ObsEva (OBSV) 26-Jan-2017 Switzerland Developer of innovative drugs for women's reproductive health and pregnancy. 96.75 Leerink Partners

Developer of therapeutic antibodies for inflammation and immuno-oncology designed to provide first- BMO Capital Markets, in-class antibody product candidates. The company's therapeutic antibodies generates somatic hyper- Credit Suisse mutation for antibody discovery and protein optimization which replicates, in vitro, the natural process Securities, Stifel AnaptysBio (ANAB) 26-Jan-2017 , CA of antibody generation, enabling medical experts to focus on unmet medical needs in inflammation. 75.00 Nicolaus & Company

J.P. Morgan Securities, Salt Lake City, Developer of medical X-ray tubes and image processing products designed to harness the power of X- Wachtell, Lipton, Varex Imaging (VREX) 20-Jan-2017 UT ray energy to pioneer advances in any application. Undisclosed Rosen & Katz Goldman, Sachs & Co., Guggenheim Bioverativ (BIVV) 12-Jan-2017 Cambridge, MA The company engages in the research, development and treatment of hemophilia. Undisclosed Securities Developer of microchip technology designed for medical analysis and sorting of cells. The company's biomedical research and microchip technology applications in extracellular vesicles, bacteriological and cell-based research enables its clients to develop point-of-care instruments performing the same assays AcouSort (ACOU) 09-Jan-2017 Lund, Sweden but without the need for access to a laboratory. 1.23 Undisclosed

Compiled by: Sumerjit Sandhu Source: Pitchbook 1 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of an autologous anti-cancer immuno-therapy that involves expansion of Edinburgh, United naturally occurring, cancer-killing T-cells over several weeks, formulating a Scottish Enterprise, TC Biopharm 31-Jan-2017 Kingdom Early Stage VC treatment for a wide-variety of different tumor types. 8.02 Nipro

Provider of cloud management services and technology intended to simplify the PE Growth/ healthcare computing environment. The company's services provide a complete Netgain Hosting 31-Jan-2017 St. Cloud, MN Expansion end-point management allowing healthcare professionals to focus on patient care. 25.00 Bluff Point Associates

Kineta 31-Jan-2017 , WA Later Stage VC Developer of novel therapeutics. 1.75 Undisclosed Investors Focal Point Pharmaceuticals 31-Jan-2017 Memphis, TN Early Stage VC Developer of products designed to treat ocular diseases. 0.08 Undisclosed Investors

Developer and manufacturer of new products designed for sample preparation in the field of electron microscopy. The company's CryoCapsule uses high-pressure vitrification (or cryogenisation), a unique process which prevents the alteration of CryoCapCell 31-Jan-2017 , France Seed Round biological structures, initially for electron-microscopy in the field of cancer research. 1.59 Seventure Partners Developer of biotechnology drugs designed to deliver the frataxin protein to the mitochondria, helping patients who, due to a genetic abnormality, are unable to Chondrial Therapeutics 31-Jan-2017 Bala Cynwyd, PA Early Stage VC produce this essential protein. 22.60 Deerfield Management Developer of proprietary interventional neuroradiology devices and delivery Oxford, United systems designed for the treatment of neurovascular diseases, particularly Cerus Endovascular 31-Jan-2017 Kingdom Later Stage VC intracranial aneurysms. 2.39 Undisclosed Investors

Valeris Medical 30-Jan-2017 Marietta, GA Angel Manufacturer of orthopedic implants and delivery systems. 1.52 Undisclosed Investors

SafePath Medical 30-Jan-2017 Methuen, MA Angel Developer of medical devices for clinicians. 0.78 Undisclosed Investors Manufacturer of electrospun biomaterials designed to help the body repair and regenerate its own tissues. The company's electrospun biomaterials are used in The Electrospinning Didcot, United different applications in cell-based therapies, drug discovery and regenerative Rainbow Seedfund, Company 27-Jan-2017 Kingdom Later Stage VC medicine. 0.80 Undisclosed Investors Developer of soft tissue reconstruction products designed for use in hernia repair TELA Bio 27-Jan-2017 Malvern, PA Early Stage VC and abdominal wall reconstruction. 7.39 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 2 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of a bone-seeking agent that allows delivery of high amounts of radioactivity to bone and bone tumors while reducing bone marrow suppression, enabling treatment of osteosarcoma and relief of pain from bone metastases as well CycloSam Therapeutics 27-Jan-2017 Angleton, TX Angel as reduced myelotoxicity for patients. 0.20 Undisclosed Investors Biscayne Developer of Antiepileptic Agent BIS-001 created for serious central nervous Quark Venture and Neurotherapeutics 27-Jan-2017 , FL Early Stage VC system disorders, such as refractory epilepsy. 3.00 GF Securities

Airing 27-Jan-2017 Burlington, Canada Angel Maker of a micro-CPAP device that relaxes people suffering from sleep apnea. 1.90 Undisclosed Investors

Provider of online mental health treatment services that delivers therapy via college and university counseling centers, employee assistance programs, outpatient and FAN Fund, New TAO 26-Jan-2017 Saint Petersburg, FL Angel inpatient medical and mental health centers, and private practitioners. 1.56 World Angels Developer of an infusion therapy designed to enable patients to achieve stable plasma L-DOPA concentrations and to provide convenient, noninvasive, SynAgile 26-Jan-2017 Wilson, WY Angel continuous dopaminergic stimulation. 4.68 Undisclosed Investors

Developer of a cardiac device designed to improve vein performance in coronary artery bypass. The company's cardiac device creates a support layer around the vein using a novel process called electrospinning allowing nutrients and new cells to Neograft Technologies 26-Jan-2017 Taunton, MA Later Stage VC migrate into and through the support layer without deforming its natural shape. 5.00 Undisclosed Investors Developer of medical robotics, including the patented Flex Robotic System, designed to provide more patients with access to minimally invasive surgery. The company's robot-assisted surgical platform offers flexible instruments that can be deployed to perform procedures in a way that is not possible with line-of-sight Medrobotics 26-Jan-2017 Raynham, MA Later Stage VC approaches. 20.00 Undisclosed Investors

Provider of products and services intended for mutation detection and disease KromaTid 26-Jan-2017 Fort Collins, CO Later Stage VC diagnosis of genetic diseases, including cancers and developmental disorders. 0.62 Undisclosed Investors Developer of EMMA, a telehealth medical device for documented and professional INRange Systems 26-Jan-2017 Altoona, PA Later Stage VC medication administration to outpatients. 0.88 Undisclosed Investors

Developer of anti-cancer drugs focused on the treatment of patients with NOTCH- PPF Group, Cellestia Biotech 26-Jan-2017 Basel, Swaziland Seed Round dependent leukemia, lymphoma and solid tumors. 7.93 Undisclosed Investors Compiled by: Sumerjit Sandhu Source: Pitchbook 3 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Amsterdam, Developer of microbiome therapeutics created for the reduction of insulin Johnson & Johnson Caelus Health 26-Jan-2017 Netherlands Early Stage VC resistance and prevention of Type 2 diabetes in people. 2.65 Innovation Developer of a diabetes management system for people with insulin-dependent diabetes and blood sugar control, enabling patients to improve their lives through Quadrant Capital Bigfoot Biomedical 26-Jan-2017 Milpitas, CA Angel the application of smart technology. Undisclosed Advisors PE Growth/ Developer of spinal function products intended to address the unmet needs of AxioMed 26-Jan-2017 Malden, MA Expansion degenerative disc disease patients. 1.02 Undisclosed Investors BioCrossroads, Developer of therapeutics for lung diseases, like chronic obstructive pulmonary BioMotiv, Innovate Allinaire Therapeutics 26-Jan-2017 Shaker Heights, OH Seed Round disease. Undisclosed Indiana Fund

Central Texas Angel Developer of an online caregiving matching application created to connect people Network, Andrews Well Beyond Care 25-Jan-2017 Austin, TX Seed Round who need care for elderly family members with caregivers. 0.15 Kurth, Capital Factory Developer of thermal ablation therapy designed to treat cancer and cardiac Thermedical 25-Jan-2017 Waltham, MA Later Stage VC arrhythmias. 6.50 Undisclosed Investors

Manufacturer and distributor of innovative wound care products designed to be extensively used for management of burn and blast injuries. The company's Silverlon brand of dressings are uniquely designed with a silver-plated nylon matrix, PE Growth/ enabling the utilization of powerful antimicrobial properties of silver ions in the Silverlon 25-Jan-2017 Geneva, IL Expansion dressing without staining the skin and without increasing bio-burden. Undisclosed Shore Capital Partners Provider of a risk management platform that uses machine learning and predictive analytics to predict illness, improve care and optimize cost across patient Ignition Venture Kensci 25-Jan-2017 Seattle, WA Early Stage VC populations and individuals. 8.50 Partners Developer of an application platform designed for patients to choose their doctor, Doctolib 25-Jan-2017 Paris, France Later Stage VC make an appointment and monitor their health. 27.61 Bpifrance Provider of a Medicare-approved patient assessment program designed to give Hilton Head Island, physicians and organizations a baseline report detailing modifiable risk factors, BioAdvance, WellTrackONE 24-Jan-2017 SC Early Stage VC preventative goals and measurable data. 1.99 Undisclosed Investors

Redox 24-Jan-2017 Madison, WI Early Stage VC Provider of an information technology platform for healthcare systems. 9.00 RRE Ventures

Compiled by: Sumerjit Sandhu Source: Pitchbook 4 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions)

Keiretsu Capital, Developer of diagnostic devices for DNA-based detection of infections, using Keiretsu Forum, First Light Biosciences 24-Jan-2017 Bedford, MA Early Stage VC digital imaging to detect and count fluorescent targets without using magnification. 1.79 Undisclosed Investors

Connect Developer of novel immune modulators for the treatment of autoimmune diseases Biopharmaceuticals 24-Jan-2017 Taicang, China Early Stage VC and cancer created to identify therapeutic antibody drug candidates. 20.00 Qiming Venture Developer of a smartphone-based personalized ECG application created to offer CardioSecur 24-Jan-2017 Frankfurt, Germany Later Stage VC cardiac monitoring services. 5.31 KPN Ventures Developer of an electronic media application designed to treat amblyopia and other Amblyotech 24-Jan-2017 Marietta, GA Angel ocular diseases. 0.20 Undisclosed Investors

Developer of biological products, such as plasmid DNA, proteins and antibodies, that are used extensively in the fields of gene therapy and gene editing, enabling its PE Growth/ clients to manufacture novel treatments for a wide range of indications, including TA Associates Aldevron 24-Jan-2017 Fargo, ND Expansion cancer, infectious disease, pediatric disorders and rare diseases. Undisclosed Management Provider of a medication reminder system in the form of a medicine bottle cap that Smart Med Reminder 23-Jan-2017 West Lafayette, IN Later Stage VC tracks and reminds users to take medicines on time. 1.30 Undisclosed Investors Developer of a hand-held, wireless X-ray and digital imaging device that converts radiation to real time static and dynamic fluoroscopic images, enabling surgeons, doctors and healthcare providers to bring the X-ray source to the target to produce Micro C Imaging 23-Jan-2017 Savannah, GA Angel more resolute images. 0.65 Undisclosed Investors Developer of a subconscious-behavior tracker wearable device designed to manage HabitAware 23-Jan-2017 Minneapolis, MN Angel compulsive behavior. 0.51 Undisclosed Investors Developer and manufacturer of novel tissue-marking devices for use in surgery Focal Therapeutics 23-Jan-2017 Aliso Viejo, CA Later Stage VC designed to mark the surgical site of tissue removal in 3D. 0.05 Undisclosed Investors Novartis Venture Funds, Consort Developer of a novel molecular diagnostic system used for the ultra-rapid diagnosis Medical, Johnson & Trowbridge, United of a broad range of infectious diseases, such as chlamydia, gonorrhoea, meningitis Johnson Innovation - Atlas Genetics 23-Jan-2017 Kingdom Later Stage VC and MRSA, enabling physicians to get accurate diagnostic reports. 35.00 JJDC

Compiled by: Sumerjit Sandhu Source: Pitchbook 5 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of a microbiome discovery platform that mines molecular data collected from human interventional studies and uses proprietary machine learning techniques, enabling care providers and patients to treat diseases and infections Finch Therapeutics 21-Jan-2017 Somerville, MA Angel faster. 3.73 Undisclosed Investors

Developer of diagnostics devices that use proprietary thermal cycling, nucleic acid extraction and purification technologies to detect and measure patient blood samples, particularly in low resource settings, providing existing markets, as well as new markets that cannot be addressed with existing technologies, with access to Thermal Gradient 20-Jan-2017 Richmond, VA Later Stage VC faster and less expensive DNA testing products. 0.61 Undisclosed Investors

Provider of a telemedicine platform that offers physicians evaluation software to REACH Health 20-Jan-2017 Alpharetta, GA Later Stage VC assess and provide treatment options using video and patient medical data. 1.80 Undisclosed Investors

Developer of an asthma monitoring system using a contactless sensor, enabling Tueo Health 19-Jan-2017 Redwood City, CA Seed Round patients and their families to measure treatment progress and outcomes. 0.40 Undisclosed Investors Developer of small-peptide therapeutics for the treatment of gastrointestinal Rhythm Pharmaceuticals 19-Jan-2017 Boston, MA Later Stage VC functional disorders, obesity and diabetes. 20.48 Undisclosed Investors Droia, Fund+, Omnes OCTIMET 19-Jan-2017 Beerse, Belgium Early Stage VC Developer of discovery stage molecules used for the treatment of cancer cells. 12.00 Capital Developer of a novel biologics platform designed to be inactive upon administration but fully active in the tumor micro-environment, improving the MPM Capital and Maverick Therapeutics 19-Jan-2017 Brisbane, CA Early Stage VC utility of T-cell redirection therapy for the treatment of cancer. 56.00 Takeda Pharmaceutical

Developer of an online hearing solution platform that enables people with hearing Ameritas Life iHear Medical 19-Jan-2017 San Leandro, CA Later Stage VC loss to customize advanced hearing aids settings themselves at home. 4.10 Insurance Maastricht, Developer of therapies employing nanoparticle technology designed against cancer Aglaia BioMedical Cristal Therapeutics 19-Jan-2017 Netherlands Later Stage VC and chronic inflammatory disorders. 13.59 Ventures, DROIA

Alderley Park Ventures Developer of therapies for hematological cancers that reduce off-target side effects of Biocity, Finance Alderley Edge, United on healthy tissues, enabling patients to use their drugs without facing any side Wales, Undisclosed BiVictrix Therapeutics 19-Jan-2017 Kingdom Seed Round effects. 0.53 Investors Compiled by: Sumerjit Sandhu Source: Pitchbook 6 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of a diagnostic platform capable of simultaneous detection of hundreds of analytes in a single drop of fluid, enabling highly multiplexed protein detection RiverVest Venture Adarza BioSystems 19-Jan-2017 West Henrietta, NY Later Stage VC with high sensitivity and specificity. 17.00 Partners Provider of the VarLift Interbody Fusion System designed for surgeons to shorten Wenzel Spine 18-Jan-2017 Austin, TX Later Stage VC spine fusion surgeries. 1.60 Undisclosed Investors Developer of imaging systems and devices designed to detect breast cancer and guide cancer surgery, providing diagnostic accuracy while reducing side effects, and Weinberg Medical Physics 18-Jan-2017 Rockville, MD Later Stage VC enhance scientists' ability to track stem cells. 1.31 Undisclosed Investor

Developer of an oligonucleotide synthesizer designed to improve the economics, Synthomics 18-Jan-2017 Menlo Park, CA Seed Round speed, customization and quality associated with DNA and RNA synthesis. Undisclosed TEEC Angel Fund

Developer of single use disposable cartridges to capture stem and progenitor cells SynGen 18-Jan-2017 Sacramento, CA Later Stage VC from peripheral and umbilical cord blood, bone marrow and adipose tissue. 2.50 Undisclosed Investors SilverCloud (Healthcare Provider of an online health and e-therapy platform intended to improve behavioral Technology) 18-Jan-2017 Dublin, Ireland Later Stage VC health and mental wellness. 8.10 B Capital Group Developer of a suite of first-in-class therapeutic cancer vaccines based on a novel peptide platform technology targeting a key antigen expressed in a broad range of cancers and Epstein-Barr virus proteins strongly associated with nasopharyngeal SapVax 18-Jan-2017 Cleveland, OH Angel cancer, lymphoma and gastric cancer. 0.35 Undisclosed Investors

Ovid Therapeutics 18-Jan-2017 New York, NY Later Stage VC Developer of drugs for orphan diseases of the brain. 25.86 Undisclosed Investors Operator of a blood-based biomarker company focused on monitoring cancer Liquid Genomics 18-Jan-2017 Torrance, CA Early Stage VC patients for chemotherapy response. 1.63 Undisclosed Investors Developer of a therapy for patients who have received a bilateral lung transplant Renovion 17-Jan-2017 Chapel Hill, NC Angel and suffer from chronic inflammatory airway diseases. 1.87 Undisclosed Investors

Provider of an online service for scheduling appointments with doctors and storage Practo 17-Jan-2017 , India Later Stage VC of healthcare records including X-rays, files, prescriptions and billing. 55.00 Tencent Holdings

Fibrocor Therapeutics 17-Jan-2017 , Canada Early Stage VC Developer of novel therapeutics for the treatment of fibrosis. 2.12 MaRS Innovation

Compiled by: Sumerjit Sandhu Source: Pitchbook 7 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of bacterial-based therapeutics to leverage the ability of specific strains of bacteria, to potently activate the immune system against tumors and down- regulate the immune system for the treatment of autoimmune and inflammatory Evelo Biosciences 17-Jan-2017 Cambridge, MA Early Stage VC diseases. 45.50 Undisclosed Investors Developer of diagnostic tests designed to identify patients unlikely to have CardioDx 17-Jan-2017 Redwood City, CA Later Stage VC obstructive CAD. 18.13 Undisclosed Investors

Developer of MR imaging that provides body composition analysis to quantify the Pfizer Venture AMRA 17-Jan-2017 Linkoping, Sweden Later Stage VC amounts of visceral fat, subcutaneous fat, liver fat deposits and muscles. 9.00 Investments, Novo Provider of a SaaS-based platform that enables clinical personnel to pull real-time Ambassador Software patient information from the hospital's electronic medical records and use Rev1 Ventures, Ross Works 17-Jan-2017 Columbus, OH Early Stage VC predictive analytics to anticipate patient needs. 0.40 Youngs Developer of cell therapies and cancer vaccines intended to treat cancer through a Realist Pharma 16-Jan-2017 Toronto, Canada Early Stage VC patient's own immune system. 0.05 Undisclosed Investor

Connecticut Developer of pharmaceutical drugs that uniquely targets both glycemic and lipid Innovations, Thetis Pharmaceuticals 13-Jan-2017 Fairfield, CT Early Stage VC control in diabetes patients. 4.11 Undisclosed Investors Oak Park Heights, POPS! Diabetes Care 13-Jan-2017 MN Angel Developer of glucose monitoring devices for diabetic patients. 1.23 Undisclosed Investors

Maui Imaging 13-Jan-2017 Sunnyvale, CA Later Stage VC Developer of ultrasonic imaging devices via a portable system. 0.66 Undisclosed Investors

Developer of a non-surgical female sterilization device and two commercially Femasys 13-Jan-2017 Suwanee, GA Later Stage VC available products for the diagnosis of infertility and cervical cancer. 44.00 Salem Partners Developer of computer assisted medical devices for future-facing laparoscopic Virtual Possibilities 12-Jan-2017 Hamilton, Canada Angel surgeries. Undisclosed Undisclosed Investors Provider of a technology infrastructure that delivers chronic care management services to Medicare beneficiaries through a team of experienced registered nurses Signallamp Health 12-Jan-2017 Scranton, PA Angel who contact patients on a monthly basis. 0.14 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 8 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of cancer diagnosis artificial intelligence technology that applies deep learning techniques to massive aggregated sets of pathology data to build algorithms to automatically detect and diagnose medical conditions for cancer PathAI 12-Jan-2017 Boston, MA Early Stage VC patients to receive faster, accurate and reproducible diagnosis. Undisclosed Pillar Venture Capital Developer of novel immunotherapies for cancer, inflammation and autoimmune OncoImmune 12-Jan-2017 Gaithersburg, MD Later Stage VC diseases. 15.00 3E Bioventures Capital

EMBL Ventures, EMBL Enterprise Management Developer of the light-sheet microscopes that combines optical sectioning with Technology Transfer, Luxendo 12-Jan-2017 Heidelberg, Germany Early Stage VC multiple-view imaging to observe tissues and living organisms with clear resolution. 8.49 Life Science Partners Developer and manufacturer of mobile medical devices for diagnosis of common Whitecap Venture Clearwater Clinical 12-Jan-2017 Ottawa, Canada Later Stage VC medical conditions. 6.00 Partners PE Growth/ Provider of health information technology intended to provide release of Verisma Systems 11-Jan-2017 Pueblo, CO Expansion information services. 2.50 Undisclosed Investors

Manufacturer of custom prosthetic covers for amputees. The company offers Graph Ventures, reimagining orthotics and prosthetics by 3D printing and handcrafting custom, HealthTech Capital, Unyq Design 11-Jan-2017 , CA Early Stage VC fashionable fairings and accessories that embellish and restore body symmetry. 4.28 Undisclosed Investors Provider of gene-based food and lifestyle recommendations designed to build a ToolBox Genomics 11-Jan-2017 San Francisco, CA Seed Round healthier life and reduce risk of chronic conditions. Undisclosed Undisclosed Investors Developer of protein inhibitors for the treatment of ocular diseases, such as SemaThera 11-Jan-2017 Montreal, Canada Angel diabetic macular edema. 1.00 Undisclosed Investors OtoNexus Medical Developer of medical devices for data physicians that uses air-coupled ultrasound Technologies 11-Jan-2017 Seattle, WA Later Stage VC technology to assess middle ear infections. 7.85 Undisclosed Investors Developer of therapies designed to activate a patient's immune system to defeat IRX Therapeutics 11-Jan-2017 New York, NY Angel cancer and related diseases. 13.24 Undisclosed Investors Developer of medical devices to collect stem cells and deliver tissues to damaged EndoCellutions 11-Jan-2017 Marshfield, MA Angel areas. 0.60 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 9 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer, manufacturer and marketer of a device that applies pulsing forces in S3 Ventures, combination with standard orthodontics to move teeth faster through accelerated HealthpointCapital, bone remodeling allowing patients to have a reduced treatment duration for Piper Jaffray Merchant AcceleDent 11-Jan-2017 Bellaire, TX Later Stage VC wearing braces. 5.00 Banking Laboratory Provider of diagnostic tests for early prediction of preterm birth, preeclampsia and Corporation of Sera Prognostics 10-Jan-2017 Salt Lake City, UT Later Stage VC other pregnancy complications. 40.00 America Developer of a microfluidic platform for rapid, point-of-care serum screening that uses antibodies to detect biomarkers using a novel and compact microfluidics POC Medical Systems 10-Jan-2017 Livermore, CA Early Stage VC system containing a built-in reading mechanism. 20.40 BioVentures Investors Provider of non-surgical treatment for kidney stones using extracorporal shock Piedmont Stone Center 10-Jan-2017 Winston-Salem, NC Angel wave lithotripsy. 0.57 Undisclosed Investors Vinod Martin, Evan Lim, Kanchan Medinfi Healthcare 10-Jan-2017 Bangalore, India Angel Provider of an online platform to browse and find doctors and hospitals. 0.10 Ghoshal Developer of a device that provides cyclic thrusting pressure to the foot capillary Footbeat 10-Jan-2017 Grand Junction, CO Angel bed at the plantar venous plexus. 7.60 Undisclosed Investors Provider of a platform that helps hospitals improve patient engagement and gather Bioscape Digital 10-Jan-2017 Atlanta, GA Angel feedback. 0.53 Undisclosed Investors Provider of a technology platform for physicians to help deliver care to their Aledade 10-Jan-2017 Bethesda, MD Early Stage VC patients while reducing overall costs. 20.00 Biomatics Capital Developer of proprietary technologies based on a silk biopolymer platform for Vaxess Technologies 09-Jan-2017 Boston, MA Later Stage VC encapsulating and stabilizing biological compounds. 0.86 Undisclosed Investors Developer of a sensor-based wearable device that monitors heartbeat rate and detects heart related disorders, preventing heart attacks and similar fatal health ReThink Medical 09-Jan-2017 San Francisco, CA Angel conditions. 3.22 Undisclosed Investors PE Growth/ PeraHealth 09-Jan-2017 Charlotte, NC Expansion Developer of a technology platform for predicting patient risk. 14.00 Mainsail Partners Provider of a drug discovery platform that utilizes engineered gut bacteria for treating disease through the development of tools for controlling their abundance Novome Biotechnologies 09-Jan-2017 Daly City, CA Angel in patients. 0.54 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 10 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of a responsive neurostimulator system for the treatment of medically KCK, Undisclosed NeuroPace 09-Jan-2017 Mountain View, CA Later Stage VC refractory partial epilepsy. 50.00 Investors Berkhamsted, United Developer of novel therapies to enhance anti-tumour immune responses to boost Cancer Research Macrophage Pharma 09-Jan-2017 Kingdom Early Stage VC up the body's natural immune system to fight cancer. 11.10 Technology Provider of a digital health application that enables users to store and manage their Thieme, High-Tech health data digitally and import reports or X-rays directly after medical Gründerfonds, LifeTime 09-Jan-2017 Hamburg, Germany Early Stage VC consultations. 1.06 Fraunhofer-Society Developer of a minimally invasive microsurgical procedure for the treatement of glaucoma and other eye diseases that reduces eye pressure by re-establishing the RA Capital Ivantis 09-Jan-2017 Irvine, CA Later Stage VC patient's natural outflow pathway. 25.00 Management Developer of a therapy of small molecule inhibitors for dietary-related metabolic diseases by addressing sodium coupled citrate transporter NaCT, which is a key regulator of lipid metabolism involved in the pathogenesis of fatty liver, diabetes Eternygen 09-Jan-2017 Berlin, Germany Early Stage VC and obesity. 8.49 Epidarex Capital

Developer of a platform that combines on-premise, on-demand, web-based, SaaS Howard Goldstein, dashboards and reports and analytic support services for emergency departments, John Martinson, Beta d2i (Healthcare Analytics) 09-Jan-2017 Parsippany, NJ Angel as well as other clinical departments. Undisclosed Operators Fund

Corbin Therapeutics 09-Jan-2017 Montreal, Canada Seed Round Provider of a drug discovery platform to treat various inflammation-based diseases. 0.76 Undisclosed Investors

Developer of a technology platform addressing body pain at its molecular roots. The company develops a technology that prevents the development of pain Adynxx 09-Jan-2017 San Francisco, CA Later Stage VC following surgery or trauma and resolving established chronic pain syndromes. 16.00 TPG Biotech Provider of self-service consumer healthcare utilizing technology to develop and Pursuant Health 08-Jan-2017 Atlanta, GA Later Stage VC deploy interactive healthcare platforms and kiosks. 12.80 Undisclosed Investors Provider of a platform that enables patients to virtually receive ancillary care treatments such as nutrition, fitness and behavior modification and helps improve Virtual Health Partners 06-Jan-2017 New York, NY Angel post-care patient compliance. 1.62 Undisclosed Investors ARCH Venture Partners, Bill & Developer of a cure for infectious diseases through immune programming to Melinda Gates Vir Biotechnology 06-Jan-2017 San Francisco, CA Early Stage VC manipulate pathogen-host interactions. 150.00 Foundation Compiled by: Sumerjit Sandhu Source: Pitchbook 11 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Southlake Equity PE Growth/ Designer and manufacturer of titanium interbody cage devices utilized in the spinal- Group, Undisclosed Titan Spine 06-Jan-2017 Mequon, WI Expansion fusion surgical process. 9.17 Investors Developer of a mobile application that can be attached to a matiscope device for ThinkIT 06-Jan-2017 Kampala, Uganda Angel detecting and diagnosing malaria. 0.10 Undisclosed Investors Provider of a suite of software tools created to increase patient education and improve health outcomes through chronic condition management, smart triage Tesser Health 06-Jan-2017 Miami, FL Seed Round tools and medication adherence. 0.47 Cofounders Capital Developer of a treatment for neuropathic pain through novel pain therapeutics SiteOne Therapeutics 06-Jan-2017 Bozeman, MT Later Stage VC without the limitations of existing drugs, such as opioids. 15.00 Amgen Developer of technology-enhanced pharmaceutical products for epilepsy and HBM Healthcare Neurelis 06-Jan-2017 Encinitas, CA Later Stage VC central nervous system disorders. 20.00 Investments Developer of surgical devices for the treatment of urological and gynecological NeoTract 06-Jan-2017 Pleasanton, CA Later Stage VC disorders. 12.82 Undisclosed Investors Developer of a smartphone-connected thermometer that provides a real-time map and information on user's health temperature, symptoms and medication on a Kinsa 06-Jan-2017 San Francisco, CA Early Stage VC connected smartphone. 14.07 Undisclosed Investors Developer of a web-based platform for healthcare providers to send invoices, process payments, and track patient interaction with invoices related to medical Inbox Health 06-Jan-2017 Bridgeport, CT Early Stage VC services they provide. 3.01 Undisclosed Investors Healthie 06-Jan-2017 Lewes, DE Seed Round Provider of a web and mobile platform for dietitians and nutritionists. 0.99 Dorm Room Fund Provider of healthcare management services. The company provides a mobile and web-based software system to improve physician communication with their Diagnotes 06-Jan-2017 Indianapolis, IN Later Stage VC patients, care teams and office staff. 1.00 Undisclosed Investors Lilly Ventures, Novartis Venture Cavion 06-Jan-2017 Charlottesville, VA Later Stage VC Developer of oncology drugs for the treatment of cancer. 26.10 Funds

Echo Health Ventures, Provider of laboratory benefits management services by reducing unnecessary BlueCross BlueShield Avalon Healthcare utilization, optimizing network and increasing scores for payers through quality of South Carolina, Solutions 06-Jan-2017 Tampa, FL Early Stage VC improvement. Undisclosed Francisco Partners

Compiled by: Sumerjit Sandhu Source: Pitchbook 12 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) KCK Group, Excel Venture Management, Lilly Ventures, Developer of novel therapeutics for the treatment of cancer using proprietary cell Novartis Venture Aileron Therapeutics 06-Jan-2017 Cambridge, MA Later Stage VC permeable peptide technology. 30.11 Funds Developer of healthcare therapies for achondroplasia (short-limbed dwarfism) and Therachon 05-Jan-2017 Biot, France Early Stage VC its associated complications. 40.00 OrbiMed

The Pill Club 05-Jan-2017 Redwood City, CA Angel Developer of a mobile application software for medicine delivery. 3.18 Undisclosed Investors Provider of neurosurgical technological products and services. The company PE Growth/ provides advanced tools and information for neurosurgeons, radiologists, surgeons General Atlantic, Synaptive 05-Jan-2017 Toronto, Canada Expansion and hospitals to focus on patient outcomes. 5.54 Undisclosed Investors RA Capital Management, TPG Satsuma Pharmaceuticals 05-Jan-2017 San Francisco, CA Early Stage VC Developer of nasal migraine drugs. 12.00 Biotech PE Growth/ PaySpan 05-Jan-2017 Jacksonville, FL Expansion Provider of healthcare reimbursement and payment automation services. Undisclosed Primus Capital Funds Fountain Healthcare Developer of clinical and pre-clinical neurokinin receptor antagonists for the Partners, Forbion Stevenage, United treatment of common, chronic and debilitating conditions caused by neuronal Capital Partners, NeRRe Therapeutics 05-Jan-2017 Kingdom Early Stage VC hypersensitivity. 28.37 OrbiMed Developer of neoantigen-based therapeutic vaccines and T-cell therapies to treat Partner Fund Neon Therapeutics 05-Jan-2017 Cambridge, MA Early Stage VC cancer. 70.00 Management Developer of proprietary technology that analyzes circulating cell-free RNA in a blood sample to monitor organ damage and provide early detection of hard-to- Data Collective, Pfizer, Molecular Stethoscope 05-Jan-2017 San Diego, CA Seed Round detect diseases. 8.20 Index Ventures Developer of antimicrobial therapeutics to prevent microbial biofilms from Quark Ventures, GF Microbion 05-Jan-2017 Bozeman, MT Later Stage VC forming on medical devices implanted in the body. 25.00 Securities

Jupiter Orphan Developer of therapies for treatment of rare diseases linked to single gene Tarnagulla Ventures, Therapeutics 05-Jan-2017 Jupiter, FL Early Stage VC deficiencies. 2.50 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 13 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Provider of an intravenous infiltration detector device designed to monitor the status of a patient's IV therapy to aid in the early detection of peripheral IV ivWatch 05-Jan-2017 Hampton, VA Angel infiltrations. 9.29 Undisclosed Investors Developer of a blood glucose meter and multi-test cartridge that provides automatic testing with lancing, blood collection and analysis without the need for PTV Healthcare Intuity Medical 05-Jan-2017 Sunnyvale, CA Later Stage VC separate strips and lancets. 55.00 Capital, KCK Group Boehringer Ingelheim Developer of drugs for treating acute and chronic liver diseases that effectively Venture Fund, Novo HepaRegenix 05-Jan-2017 Germany Early Stage VC restore the regenerative capacity of hepatocytes. 9.56 Seeds

Developer of molecular diagnostic tests for oncologists and patients that identifies GeneCentric Diagnostics 05-Jan-2017 Durham, NC Early Stage VC patients who would benefit from drugs that inhibit tumor growth. 6.11 Undisclosed Investors

CiVi Biopharma 05-Jan-2017 San Francisco, CA Early Stage VC Developer of treatments and therapies against cardiometabolic diseases. 40.00 Tavistock Group South San Francisco, ARCH Venture Blackthorn Therapeutics 05-Jan-2017 CA Early Stage VC Developer of therapeutic drugs for neurological disorders. 54.00 Partners

Avidity Biosciences 05-Jan-2017 San Diego, CA Early Stage VC Developer of an antibody cancer therapy utilizing nanoparticle technology. 16.00 Takeda Ventures GE Ventures, Merck Global Health Operator of an electronic health record data aggregation and analytics technology Innovation, Morgan company. The company offers data integration from over 30 EHR vendors, Stanley, Peloton Arcadia Healthcare PE Growth/ enriching it with claims and operational data, and using that data to drive Equity, Zaffre Solutions 05-Jan-2017 Burlington, MA Expansion improvements in patient care quality, practice efficiency and financial performance. 30.00 Investments

Marico Innovation Manufacturer of medical devices that enables medical professionals to diagnose and Foundation, Villgro Yostra Labs 04-Jan-2017 Bengaluru, India Early Stage VC treat diabetic peripheral neuropathy and diabetic foot ulcers. Undisclosed Innovation Marketing

Synthego 04-Jan-2017 Redwood City, CA Early Stage VC Developer of a precision tool to automate genome engineering research. 41.00 8VC Pionyr Developer of drugs for immunotherapy to identify and target novel arms of the SV Life Sciences Immunotherapeutics 04-Jan-2017 San Francisco, CA Early Stage VC immune response within the tumor micro environment. 8.00 Advisers, OrbiMed

Compiled by: Sumerjit Sandhu Source: Pitchbook 14 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions) Developer of advanced analytics to assess the complex genomic heterogeneity in Slater Technology Medley Genomics 04-Jan-2017 Providence, RI Seed Round biological samples and support targeted therapies. 0.25 Fund

Developer of a telehealth and remote conferencing software platform that allows medical experts to reach out to their patients through telemedicine anywhere without being physically present. It also provides workflow management software, store-and-forward capabilities with electronic health record integration and a line of Avizia 04-Jan-2017 Reston, VA Early Stage VC peripherals, such as digital stethoscopes and examination cameras. 20.00 HealthQuest Capital Accelerator/ Developer of a treatment for cancer that involves activating a controlled cell-killing Merck Ventures Israel Artsavit 04-Jan-2017 , Israel Incubator mechanism called an apoptosis. Undisclosed BioIncubator

Provider of an intelligence platform for clinicians to assist primary care providers in College of AristaMD 04-Jan-2017 San Diego, CA Early Stage VC offering expanded specialty care to reduce unnecessary referrals. Undisclosed Osteopathic Medicine

Developer of novel medical strategies intended to improve organ, tissue and cellular preservation to overall enhance patients' wellness. It is used in preservation Caixa Capital Risc, Transplant Biomedicals 03-Jan-2017 , Spain Early Stage VC of the organs during transport from the donor hospital to the transplant center. 2.65 Kereon Partners Provider of a technology-enabled health community integrator for chronic disease Sandbox Industries, Solera (Health Network) 03-Jan-2017 Phoenix, AZ Early Stage VC prevention programs. 9.00 SJF Ventures

Provider of an acoustic droplet ejection technology that focuses on ultrasonic Labcyte 03-Jan-2017 Sunnyvale, CA Later Stage VC acoustic energy into a fluid sample to eject droplets of liquid from open wells. 5.00 Undisclosed Investor

Developer of products for minimally invasive peripheral vascular procedures. The company offers a tack-it endovascular stapler system that is designed to optimize New Enterprise Intact Vascular 03-Jan-2017 Wayne, PA Early Stage VC peripheral balloon angioplasty results in the treatment of peripheral artery disease. 46.00 Associates Developer of new treatments for cancer and infectious diseases, with both small Ascletis 03-Jan-2017 Hangzhou, China Early Stage VC molecule and biologics approaches. 100.77 C-Bridge Capital SDIC Innovation Developer of small-molecule targeted therapeutics for cancer, hepatitis B and age- Investment Ascentage Pharma 03-Jan-2017 Shanghai, China Later Stage VC related diseases. 72.00 Management Orello Hearing Accelerator/ Developer of a hearing aid designed to make hearing healthcare more accessible Technologies 01-Jan-2017 Surrey, Canada Incubator and affordable for individuals who are hard of hearing. 0.05 The Next Canada Compiled by: Sumerjit Sandhu Source: Pitchbook 15 Monthly Healthcare Review January 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month. Last Last Financing Company Name Financing HQ Location Round Description Lead Investor(s) Size Date (Millions)

AFTx 01-Jan-2017 Westminster, CO Angel Developer of diagnostic equipment and other medical devices. 0.41 Undisclosed Investors

Compiled by: Sumerjit Sandhu Source: Pitchbook 16 Monthly Healthcare Review January 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions)

Provider of healthcare technology strategic planning, product selection and contracting, disaster recovery or business continuity systems, clinical system integration and health CompuVision Sagewood Systems Santa Barbara, CA 31-Jan-2017 information, enabling healthcare providers to meet day to day IT management challenges. Undisclosed Soesterberg, Manufacturer of dental 3D printing materials specializing in photopolymer, thermoplastic, 3D Systems Nextdent Netherlands 31-Jan-2017 polymer and monomer materials. Undisclosed Hologic (Blood Screening Joint Developer of blood-screening products and services used to scan donated blood for Grifols Venture) San Diego, CA 31-Jan-2017 viruses, including HIV, Hepatitis C and B and Zika. 1,850.00 Developer of innovative spinal and orthobiologics created to improve patient outcomes ChoiceSpine Exactech Spine Gainesville, FL 31-Jan-2017 and restore spine health. Undisclosed Manufacturer of hemp extract products that help in controlling epileptic seizures, reducing pain and inflammation, and may also be an effective treatment for mental health disorders, PotNetwork Holdings Diamond CBD Fort Lauderdale, FL 31-Jan-2017 such as addiction and various forms of psychosis. Undisclosed Provider of physician-led telemedicine management and physician coverage services InTouch Health C30 Medical Ojai, CA 31-Jan-2017 intended to provide cost-effective remote physician services. Undisclosed Provider of life sciences strategy consulting services designed to develop high tailored commercialization strategies for rare disease, oncology, immunology, neuroscience and CRA International C1 Consulting Summit, NJ 31-Jan-2017 specialty biopharma. Undisclosed Bradford, United ESI Process Sunflower Medical Kingdom 30-Jan-2017 Manufacturer of healthcare equipment and furniture for hospitals and clinics. Undisclosed Developer of medical supply chain management software designed to simplify the PAR Excellence caregivers' day-to-day inventory management tasks and allow them to focus on their core Northlane Capital Partners Systems Cincinnati, OH 30-Jan-2017 objective of patient care. Undisclosed Supplier of exempt medicinal products, enabling large and small biotech companies to provide life cycle management of their product portfolio, from pre-launch medicines right DCC Healthcare Medisource Ireland Wicklow, Ireland 26-Jan-2017 through to discontinuation strategies for mature products. 33.98 Bilthoven, Kuros Xpand Biotechnology Netherlands 25-Jan-2017 Developer of technologies for bone repair. Undisclosed Developer of therapeutics for the treatment of cancer and other diseases on a dramatically Sumitomo Dainippon Tolero shortened time-frame and at a much lower cost than traditional drug development, helping Pharma Pharmaceuticals Lehi, UT 25-Jan-2017 patients reduce suffering. 780.00

Compiled by: Sumerjit Sandhu Source: Pitchbook 17 Monthly Healthcare Review January 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Provider of home oxygen therapy and sleep therapy services using appropriate biomedical equipment, technologies and the support of qualified and suitable personnel, enabling the Air Liquide Oxymaster Bogotá, Colombia 24-Jan-2017 patients and clients to access timely and quality services. Undisclosed Developer, manufacturer and seller of nanomechanical test instruments to measure Bruker Hysitron Minneapolis, MN 24-Jan-2017 mechanical properties of materials at the nanoscale. Undisclosed Edwards Lifesciences Valtech Cardio Or Yehuda, Israel 23-Jan-2017 Developer of implanted cardiac devices for mitral valve repair and replacement. 690.00 Developer of a bioinformatics software designed to detect structural variants from next- generation sequencing data, enabling medical, pharmaceutical and agricultural research Omicia Spiral Genetics Seattle, WA 23-Jan-2017 organizations to analyse DNA data. Undisclosed Developer of a novel biopharmaceutical platform to address chronic and hard-to-heal Leap Therapeutics MacroCure Radnor, PA 23-Jan-2017 wounds, such as diabetic foot ulcers and venous leg ulcers. Undisclosed

Developer of a health intelligence platform designed to support clinical workflows and engage patients in plans of care, providing patients with curated content, atomized care plans and direct connections to their care team enabling patients to have a better health Samepage Health Health123 Seattle, WA 23-Jan-2017 literacy and empowerment for better health, satisfaction and loyalty. Undisclosed

Developer of a mobile enterprise communications platform designed to exchange patient data between EMR and practice management systems. The company's platform allows online scheduling and pre-registration, moves to the point of care with paperless Seamless Medical registration, insurance verification and payment, and continues with patient GetWellNetworks Systems Santa Fe, NM 20-Jan-2017 communications and ongoing practice marketing, queue management and patient surveys. Undisclosed Megadyne Medical Manufacturer of electrosurgical tools created to save time and cost for surgeons, nurses, Tethicon Products Draper, UT 20-Jan-2017 and hospitals. Undisclosed

Developer of next-generation gene synthesis that automates production of DNA constructs Ginkgo Bioworks Gen9 Cambridge, MA 20-Jan-2017 and improve genes, pathways, genomes and organisms using synthetic biology techniques. Undisclosed Hema Diagnostic Manufacturer of proprietary infectious disease detection devices for HIV/AIDS, Generex Biotechnology Systems Miramar, FL 19-Jan-2017 tuberculosis, malaria and other infectious diseases. 15.00 Provider of a web-based care management platform that provides state-of-the-art technology supporting point-of-service decision making, unique specialty pharmacy care management programs and near real-time updates on activities and interactions with AssistRx Caret (US) Ann Arbor, MI 19-Jan-2017 patients. Undisclosed

Compiled by: Sumerjit Sandhu Source: Pitchbook 18 Monthly Healthcare Review January 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Manufacturer of point-of-care hemostasis management products designed to focus on Instrumentation creating best-in-class products that provide more timely, precise information, leading to Laboratory Accriva Diagnostics San Diego, CA 19-Jan-2017 improved treatment outcomes. Undisclosed Provider of pharmaceutical prescription products to treat pain and other central nervous Zydus Cadila Sentynl Therapeutics Solana Beach, CA 18-Jan-2017 system conditions through innovative therapeutics. 171.00

Healthcare Data Provider of health technology information services to physician groups to implement and Solutions (Healthcare support their ongoing system needs such as telemedicine, patient portal and other related Aprima Medical Software Technology Systems) Coral Gables, FL 18-Jan-2017 services. Undisclosed

Statens Serum Institute (Vaccine Copenhagen, AJ Biologics Production Business) Denmark 16-Jan-2017 Manufacturer of vaccines. Undisclosed

Kitov Pharmaceuticals TyrNovo Kiryat-Shmona, Israel 13-Jan-2017 Developer of small molecular drugs for the treatment of cancer and inflammation diseases. 3.80

Alfasigma Pamlab Covington, LA 13-Jan-2017 Developer of prescription pharmaceuticals addressing elevated homocysteine levels. Undisclosed Producer and distributor of infection control, barriers, safety eye wear and other infection Hu-Friedy Manufacturing Palmero Stratford, CT 13-Jan-2017 prevention and safety related products for dental care. Undisclosed Developer of medicines and drugs for treating cancer, obesity, Type 2 diabetes, liver Suwon-si, South disease, MELAS syndrome, dry eye syndrome, atopic dermatitis and other metabolic Yungjin Pharm KT&G Life Sciences Korea 13-Jan-2017 diseases. 38.50 Provider of healthcare data and guidelines to the workers' compensation industry. The Work Loss Data company provides its services to insurance companies, employers, healthcare providers and MCG Health Institute Encinitas, CA 12-Jan-2017 state-run agencies. Undisclosed Quality Engineering Provider of project quality management, consultancy, analysis and other related services for ÅF Group Gävle, Sweden 12-Jan-2017 the energy, life science and process industries. Undisclosed M Pharmaceutical 40 J's Cincinnati, OH 12-Jan-2017 Developer of medical and pharmaceutical drugs. 5.50

Predicata Healthcare TRIOSE Solutions Riverside, RI 11-Jan-2017 Provider of actionable and smart analytic services to hospitals. Undisclosed

Compiled by: Sumerjit Sandhu Source: Pitchbook 19 Monthly Healthcare Review January 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Wholesaler of pharmaceutical products, such as medicines, medical equipment, laboratory Galenica Pharmapool Widnau, Switzerland 11-Jan-2017 articles, toiletries and related products. 27.64 Manufacturer of honey-based medicines that provides antibacterial and anti-inflammatory Derma Sciences Medihoney Richlands, Australia 11-Jan-2017 treatments. 18.25

Provider of bio analytical accelerator mass spectrometry services for drug development. The company conducts micro-dosing, pre-clinical evaluation, intravenous pharmacokinetics, Pharmaron Xceleron Germantown, MD 10-Jan-2017 metabolite profiling and mass balance investigations in humans. Undisclosed

Chembio Diagnostics RVR Diagnostics Subang Jaya, Malaysia 10-Jan-2017 Manufacturer and supplier of diagnostic products. 3.50 Developer of ophthalmic technology to improve the sight, care and life of visually impaired Roche Holdings ForSight Labs Menlo Park, CA 10-Jan-2017 patients. Undisclosed Operator of medical cannabis clinics offering cannabis-based therapies that are used to treat a host of conditions, including chronic pain from cancer, rheumatoid arthritis and fibromyalgia, neurological conditions like epilepsy and multiple sclerosis, Crohn's Disease, Mettrum Bodystream Barrie, Canada 10-Jan-2017 IBS and other bowel conditions. 1.00

Provider of multi-omics data management infrastructure services to pharmaceutical and biotech companies, universities, hospitals and research institutes to research disease causes, QIAGEN OmicSoft Cary, NC 09-Jan-2017 discover drugs for genetic diseases and understand human genome. Undisclosed Developer of immunotherapy treatments for long-term survival of cancer patients by combining two main approaches to cancer treatment: immune checkpoint inhibition and RXi Pharmaceuticals MirImmune Cambridge, MA 09-Jan-2017 cell-based immunotherapies. Undisclosed

PENTAX Medical C2 Therapeutics Redwood City, CA 09-Jan-2017 Provider of ablation therapies to improve treatment of precursors to esophageal cancer. Undisclosed Pamplona Capital Management and Developer of revenue cycle management services, patient access services, physician practice Northwell Health Formativ Health New York, NY 06-Jan-2017 management and advisory services to its clients in the healthcare industry. Undisclosed Provider of patient insight networks that collect, curate and share patient and clinician Invitae AltaVoice San Mateo, CA 06-Jan-2017 reported health data. 15.00

Georgia Healthcare Group ABC Pharmacia Tbilisi, Georgia 06-Jan-2017 Retailer and wholesaler of pharmaceutical goods. 25.00

Compiled by: Sumerjit Sandhu Source: Pitchbook 20 Monthly Healthcare Review January 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions)

Provider of a technology-enabled financial engagement platform that offers patient Frontier Capital AccessOne Charlotte, NC 05-Jan-2017 payment options designed for patient consumers to manage their healthcare costs. Undisclosed Manufacturer of medical devices in clinical areas of cardiac rhythm management, atrial Abbott Laboratories St. Jude Medical Saint Paul, MN 04-Jan-2017 fibrillation, cardiovascular and neuromodulation. 25,000.00

Provider of monoclonal antibodies and recombinant proteins. The company offers a complete range of biotech services, from cloning, screening and recombinant expression of InVivo Biotech Hennigsdorf, antigens, to the generation of hybridoma cell lines and from characterization of antibodies, Bruker Services Germany 04-Jan-2017 to final production of the developed monoclonal antibodies. Undisclosed Roosendaal, Producer of stoma care products. The company specializes in the manufacturing of ConvaTec EuroTec Beheer Netherlands 04-Jan-2017 colostoma, ileostoma, urostoma, kinderzakjes and ostomate. 26.55

Manufacturer of a pharmacological stress agent that simulates the effects of exercise in the Rapiscan Pharma hearts of adult patients and offers an alternative screening method for patients who are GE Healthcare Solutions Palo Alto, CA 03-Jan-2017 unable to undergo traditional cardiac stress imaging procedures. Undisclosed Developer of a percutaneous transfacet compression device for posterior stabilization of the cervical spine. It also provides a family of expandable cages that are used in spinal fusion surgery to restore the natural disc height that is designed to provide optimal tactile DePuy Synthes Interventional Spine Irvine, CA 03-Jan-2017 feedback for the surgeon. Undisclosed Manufacturer of hearing instrument fitting, audiologic diagnostics, audiological test Natus Medical GN Otometrics Taastrup, Denmark 03-Jan-2017 equipment and audio measuring equipment. 145.00 McKesson Pharmacy Provider of hospital pharmaceutical cost containment software and services to healthcare Optimization Pharmatek Systems Parsippany, NJ 01-Jan-2017 providers and health systems. Undisclosed

Consumer Healthcare Boehringer Ingelheim Business of Boehringer (consumer healthcare Ingelheim / Rhein, Developer of medicines for cough and cold, sore throat, general pain, gastro-intestinal Ingelheim business) Germany 01-Jan-2017 disorders and vitamins and minerals for physical and mental well-being. 8,000.00

Compiled by: Sumerjit Sandhu Source: Pitchbook 21