Monthly Healthcare Review July 2017 IPOs The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

Last Last Financing Financing Company Name HQ Location Description Lead Manager Date Size (Millions) Promore Pharma Owner and operator of a bio-pharmaceutical company developing therapeutic peptides for (PROMO) 6-Jul-17 Solna, Sweden treating local wounds and infections. 8.74 Undisclosed

Network 1 Financial Operator of a molecular diagnostics company offering a DNA-based testing platform that Securities, Network Co-Diagnostics specializes in the development of probes for real-time PCR to its customers. It also 1 Securities, (CODX) 12-Jul-17 Sandy, UT develops a design and analytics software for DNA test designing. 7.07 WallachBeth Capital The company is engaged in the extraction and purification of heparin glycosaminoglycan NKF Pharmaceuticals and develops a controlled, traceable, and detectable process for the production of crude (603707) 13-Jul-17 Nanjing, China heparin. 67.22 Undisclosed NextCell Pharma Huddinge, (NEXTCL) 13-Jul-17 Sweden Provider of medical products for autoimmune and inflammatory diseases and transplants. 2.88 Undisclosed Akcea Therapeutics Developer of RNA-targeted antisense therapeutic products created to transform the lives of BMO Capital (AKCA) 14-Jul-17 Cambridge, MA patients with serious cardiometabolic lipid disorders. 175.00 Markets Provider of nutritional supplements and medical devices for the restoration of the ability to PharmaNutra (PHN) 18-Jul-17 Pisa, Italy articulate and movement in osteoarticular affections. Undisclosed Undisclosed Developer of innovative nanoparticle-based treatments created to treat ocular diseases BofA Merrill Lynch, Kala Pharmaceuticals affecting both front and back of the eye, such as dry eye disease and post-surgical ocular J.P Morgan (KALA) 20-Jul-17 Waltham, MA inflammation and pain. 90.00 Securities

JP Morgan Chase & Co, Itaú Unibanco Montevideo, Developer, manufacturer, and distributor of advanced medicines for gastroenterology, Holding, Grupo Grupo Biotoscana 21-Jul-17 Uruguay respiratory disease, and immunology. 407.24 BTG Pactual BMO Capital Sienna Markets, Cowen and Biopharmaceuticals Westlake Provider of medical dermatology and aesthetics treatment therapies for the treatment of Company, J.P (SNNA) 27-Jul-17 Village, CA inflammatory skin conditions. 65.00 Morgan Securities

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 1 Monthly Healthcare Review July 2017 Private Equity Placements and Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of an online platform that matches patients' records with the world's largest knowledge-base of cancer trials and helps to Mendel.ai 1-Jul-17 , CA Seed Round contact and enroll patients in clinical trials. Undisclosed SOSV Siegfried Holding Zofingen, (SFZN) 1-Jul-17 Switzerland PIPE Developer and manufacturer of pharmaceutical products. Undisclosed Norges Bank Lightspeed Venture Partners, LionBird, Developer of non-invasive electrical nerve stimulation medical devices Corundum Open Theranica 3-Jul-17 Netanya, Israel Early Stage VC created to treat migraines and other common illnesses. 6.00 Innovation

Scottish Enterprise, TRI Cap, Strathtay Ventures, Braveheart Investment Selkirk, United Developer of nano-technology and gene therapy designed to treat Group, Brian Kennedy, Ryboquin 3-Jul-17 Kingdom Early Stage VC cancer. 2.02 Brian Souter

Developer of optical diagnostic devices that offer artificially intelligent MobileODT 4-Jul-17 , Israel Early Stage VC visual diagnostic tools to conduct visual inspections and detect cancer. 6.83 OrbiMed, Tristel Secondary Manufacturer of pharmaceutical products, including generic drugs, Transaction - hospital equipment, herbal medicines, food supplements, and other Mr. Marcelo Leite Teuto Pfizer 4-Jul-17 Anapolis, Brazil Private related products. Undisclosed Henriques Medicxi Ventures, JDRF T1D, McDonald's Ventures, Diasome Developer of novel and cell targeted therapies designed to treat Black Beret Life Pharmaceuticals 5-Jul-17 Cleveland, OH Later Stage VC diabetes and obesity. 30.00 Sciences

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 2 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Seventure Partners, Shinsei Corporate Developer of a genetically enhanced bacteria that fights tumors and Investment, Novartis proliferates in the hypoxic core of solid tumors where it secretes the Pharma, Mitsubishi UFJ enzyme cytosine deaminase, turning a systemically administered pro- Capital, Innovation drug into a cytotoxic agent, which hollows out the tumor from the Network Corporation Anaeropharma Science 5-Jul-17 Tokyo, Japan Later Stage VC inside. 13.20 of Japan

Direct Allergy 5-Jul-17 Erie, PA Early Stage VC Provider of immunotherapy treatments for allergy sufferers. 0.20 Undisclosed Investors Developer of blood-based cancer molecular diagnostics for patient Exosome Diagnostics 5-Jul-17 Waltham, MA Later Stage VC stratification and disease monitoring. 30.29 Undisclosed Investors Accelerator/ Hemotune 5-Jul-17 Zürich, Switzerland Incubator Developer of a medical device designed to purify blood. 0.13 Venture Kick GenePath Dx 5-Jul-17 Pune, India Angel Operator of a next generation diagnostics company. Undisclosed Undisclosed Investors

Secondary Manufacturer and developer of disposable insulin kits designed to Petach-Tikvah, Transaction - improve the current meal-time insulin therapy by providing controlled Insuline Medical (INSL) 5-Jul-17 Israel Private and consistent insulin injection site treatment and stabilization. 0.13 Mr. Kfir Zilberman PE Growth/ Jawbone Health Hub 6-Jul-17 San Francisco, CA Expansion Provider of health-related hardware and software services. Undisclosed BlackRock Capital ProMetic Life Sciences Developer of therapeutics products for fibrosis, anemia, neutropenia, Equity, Peter J. (PLI) 6-Jul-17 Laval, Canada PIPE cancer, and autoimmune disease/inflammation. 29.63 Thomson

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 3 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Edmond de Rothschild Investment Partners, Advent Life Sciences, Cormorant Asset Management, Gilde Healthcare, CICA, Legend Capital, Alfred Mann Foundation, Axonics Modulation Developer of an implantable neuromodulation technology designed NeoMed Management, Technologies 6-Jul-17 Irvine, CA Later Stage VC for the treatment of urinary and fecal dysfunction. 35.00 Undisclosed Investors Developer of biosensors for cellular biology research and screening, Innovation Works, Sharp Edge Labs 6-Jul-17 Pittsburgh, PA Seed Round and drugs for protein trafficking disorders. 2.17 Undisclosed Investors Provider of contract research services and manufacturer of biological Qiming Venture products, including recombinant proteins, monoclonal antibodies, and Partners, Undisclosed Sino Biological 6-Jul-17 Beijing, China Early Stage VC genetic vaccines, for drug R&D. 29.40 Investors The Kraft Group, Developer of a radiofrequency spectroscopy platform designed to Canepa Healthcare, Dune Medical Devices 6-Jul-17 Paoli, PA Later Stage VC detect microscopic residual cancer. 13.80 ATON Partners Developer and provider of a disease diagnosis technology that can Aperiomics 6-Jul-17 Ashburn, VA Angel simultaneously test for all pathogens. 0.06 Undisclosed Investors

Provider of a software that targets all underlying causes of Alzheimer's Muses Labs 6-Jul-17 Raleigh, NC Early Stage VC with a goal to return individuals to normal cognitive function. 2.06 Undisclosed Investors Developer of a bedside monitoring system that detects and depicts variations in pressure across a patient's body to aid in the prevention Wellsense 6-Jul-17 Nashville, TN Later Stage VC of pressure ulcers. 6.30 Undisclosed Investors Auckland, New Accelerator/ Provider of an online booking platform intended to facilitate online Vensa Health 6-Jul-17 Zealand Incubator appointment booking to available healthcare services. 0.02 Vodafone Xone

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 4 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Adams Street Partners, BlueCross BlueShield Venture Partners, Provider of a technology-enabled health community integrator for Sandbox Industries, SJF Solera (Health Network) 7-Jul-17 Phoenix, AZ Early Stage VC chronic disease prevention programs. 18.33 Ventures

London, United Provider of an online recruitment platform designed to customize, Albion Capital, IDO Locum's Nest 7-Jul-17 Kingdom Early Stage VC filter, and automate the hiring process of locum staffs. 1.41 Investments Provider of a patient education and navigation platform that tracks patient compliance and measures outcomes throughout the Total Joint Pro 7-Jul-17 Prospect, KY Angel continuum of care. 0.05 Undisclosed Investors Ferrosan Medical PE Growth/ Manufacturer of medical devices and equipment designed for Devices 7-Jul-17 Soeborg, Denmark Expansion haemostasis surgery. Undisclosed Impilo Developer of devices and technology intended for the measurement, Revenio Group monitoring, and screening of intraocular pressure for diagnosing (REG1V) 7-Jul-17 Vantaa, Finland PIPE glaucoma. 0.01 Mr. Joensuun Kauppa Provider of an e-learning and healthcare informatics platform designed to help learning, competency, and performance among ArcheMedX 7-Jul-17 Charlottesville, VA Early Stage VC healthcare professionals. 2.54 Undisclosed Investors

Ativa Medical 7-Jul-17 Saint Paul, MN Later Stage VC Developer of point-of-care testing medical diagnostic products. 9.50 Undisclosed Investors

Developer of magnetic resonance image analysis software designed to Myocardial Solutions 7-Jul-17 Morrisville, NC Later Stage VC enhance the clinical utility of cardiac magnetic resonance testing. 5.00 Undisclosed Investors Developer of human tissues and organs for pharmaceutical testing and organ transplant designed to create high resolution tissue Prellis Biologics 7-Jul-17 San Francisco, CA Seed Round scaffolds that grow into functioning human organs. 1.85 Undisclosed Investors Advanced Cancer Therapeutics 7-Jul-17 Louisville, KY Angel Developer of therapeutics designed to prevent and treat cancer. Undisclosed Frank Weisberg

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 5 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) VF Venture, Borean Copenhagen, Developer of an electrophysiology recording system designed to guide Innovation, CathVision 7-Jul-17 Denmark Later Stage VC medical professionals in cardiac ablation procedures. Undisclosed Undisclosed Investors Developer of ophthalmic drugs designed for the treatment of wet age- San Juan related macular degeneration, diabetic retinopathy, and diabetic Allegro Ophthalmics 9-Jul-17 Capistrano, CA Angel macular edema. 10.72 Undisclosed Investors Developer of compounds that act topically from nerve cell membranes and improve neural signalling to the brain stem for the New Ventures III, Enterin 10-Jul-17 , PA Early Stage VC treatment of Parkinson's disease. 12.70 Undisclosed Investors Swiss Re Group, Developer of a wearable multi-sensor platform intergrated into cloud STMicroelectronics, infrastructures to provide users with data on heart rate variability, Harmony Medical, Biovotion 10-Jul-17 Zurich, Switzerland Corporate respiratory rate, energy expenditure, and sleep and stress monitoring. 13.42 Undisclosed Investors Developer of the first absorbable IVC filter for the prevention of Adient Medical 10-Jul-17 Pearland, TX Later Stage VC pulmonary embolism. 1.74 Undisclosed Investors Developer of a predictive health management platform that combines genomic data with clinical and behavioral analysis to engage patients with their physicians in a highly-collaborative way and provide BaseHealth 10-Jul-17 Sunnyvale, CA Later Stage VC personalized disease risk assessment. 4.54 Undisclosed Investors Developer of catheter-based tools designed to treat atrial fibrillation Iowa Approach 10-Jul-17 Iowa City, IA Early Stage VC by offering access to the outside of the heart. 5.00 Undisclosed Investors Developer of a SaaS-based online healthcare platform offering online appointment booking, automated reminders, and medical self-service Bridgescale Partners, Chronometriq 11-Jul-17 Montreal, Canada Early Stage VC terminal services. 3.50 Undisclosed Investors Creathor Venture, MedTech Innovation Partners, Pontos Blueprint Genetics 11-Jul-17 Helsinki, Finland Later Stage VC Provider of genetic testing and diagnostics services. 15.71 Group, Inventure

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 6 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) HLM Venture Partners, Providence Ventures, Pioneer Venture Provider of a cloud-based patient experience platform designed to Partners, Undisclosed BinaryFountain 11-Jul-17 McLean, VA Later Stage VC engage patients, improve operations, and impact revenue. 19.92 Investors Seventure Partners, Dr. Becker Klinikgruppe, IBB Operator of an online workplace health promotion platform designed Beteiligungsgesellschaft Machtfit 11-Jul-17 Berlin, Germany Later Stage VC to promote the health of employees with a unique health network. 2.47 Berlin, PHS Capital Inimiti Capital Partners and Glilot Capital Provider of a genomic analytics platform designed to make clinical Partners, Undisclosed Genoox 11-Jul-17 Palo Alto, CA Early Stage VC genetic sequencing more accessible and affordable. 6.00 Investors Romulus Capital, Developer of Elipse Balloon, a thin, flexible polymer film that is Cogepa Investments, delivered in a swallowable capsule, eliminating the need for surgery, IDO Investments, endoscopy, or anesthesia, enabling overweight and obese individuals FundRx, Undisclosed Allurion Technologies 11-Jul-17 Natick, MA Later Stage VC to reduce weight. 27.00 Investors AFTx 11-Jul-17 Westminster, CO Angel Developer of diagnostic equipment and other medical devices. 1.34 Undisclosed Investors Innovative Developer of an embolic protection catheter designed to be utilized in Cardiovascular trans aortic valve replacement procedures and other left heart Solutions 11-Jul-17 Grand Rapids, MI Angel interventional procedures. 5.00 Undisclosed Investors

London, United Accelerator/ Developer of a medication scheduling application using artificial King's College London The Medic App 11-Jul-17 Kingdom Incubator intelligence to schedule medication reminders and track adherence. 0.04 Endowment Supplier of surgical equipment to medical centers and hospitals PE Growth/ specializing in urological laser treatments, general surgery, United Therapies 11-Jul-17 Des Plaines, IL Expansion neurosurgery, ophthalmology, and orthopedic surgery. 0.87 Undisclosed Investors Accelerator/ Provider of a mobile platform intended to match and connect people Find Your Ditto 12-Jul-17 Ann Arbor, MI Incubator living with common chronic illnesses. 0.03 Desai Accelerator Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 7 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of eldercare mobility devices, such as smart wheelchairs that help disabled people to safely access bathrooms at their homes Arcatron Mobility 12-Jul-17 Pune, India Angel and on the go. Undisclosed Indian Angel Network Developer of protein therapeutics designed to target white blood cell diseases, such as hematologic malignancies, latent infections, and Actinobac Biomed 12-Jul-17 Kendall Park, NJ Later Stage VC autoimmune diseases. 4.40 Kairos Ventures

OrbiMed, Novartis Venture Funds, Novo, Johnson & Johnson Innovation, Osage University Partners, Developer of therapeutics against genetic targets for Lilly Asia Ventures, neurodegenerative diseases, including Alzheimer's Disease and Lewy Sutter Hill Ventures, E-scape Bio 12-Jul-17 San Francisco, CA Early Stage VC Body Disease. 63.00 Undisclosed Investors

Developer of a bone reconstruction technology that utilizes a scan of Accelerator/ the bone defect and the patient's own stem cells to construct and EpiBone 12-Jul-17 Brooklyn, NY Incubator cultivate a defect-specific autologous-like bone graft. Undisclosed Grand Central Tech

Schlieren, Developer of a proteomics platfrom designed to offer innovative BiognoSYS 12-Jul-17 Switzerland Later Stage VC services and products for highly multiplexed protein quantification. Undisclosed Undisclosed Investors Developer of an immuno-oncology technology designed to harness INmune Bio 12-Jul-17 , CA Angel patients' immune systems and treat cancer. 3.34 Undisclosed Investors Developer of an intraoperative imaging system that includes a margin- targeted injectable imaging agent and hand-held imaging device that gives surgeons real-time visual feedback of residual cancer in the Lumicell 12-Jul-17 Wellesley, MA Later Stage VC tumor bed. 13.50 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 8 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of a medical device technology to decode the internal processes of the brain and improve the lifestyle of the sensory impaired - specifically profoundly deaf patients with cochlear Resonance Medical 12-Jul-17 Chicago, IL Angel implants. 0.33 Undisclosed Investors Secondary Franklin Township, Transaction - Developer and manufacturer of specialty active pharmaceutical Apicore US 12-Jul-17 NJ Private ingredients and pharmaceuticals. 24.50 Medicure Operator of a life science tools company creating novel products for Wisconsin Economic microscopy laboratories to improve specimen preparation, handling, Development Microscopy Innovations 12-Jul-17 Marshfield, WI Later Stage VC and storage. 0.15 Corporation Secondary Transaction - Provider of cloud-based electronic medical record software designed WebPT 12-Jul-17 Phoenix, AZ Private for rehab therapy professionals. 16.00 Battery Ventures Operator of a health technology company created to diagnose brain disorders using an efficient and radiation-free approach that involves BrainSpec 13-Jul-17 Boston, MA Early Stage VC software and magnetic resonance spectroscopy. 0.50 Data Collective EW Healthcare Partners, HealthQuest Capital, Madryn Asset Developer of non-surgical aesthetic equipment designed for non- Management, Venus Concept 13-Jul-17 , Canada Later Stage VC invasive cosmetic procedures. 38.00 Undisclosed Investors

Founder's Co-Op, Y Combinator, Slow Ventures, Section 32, Liquid 2 Ventures, Fifty Developer of a medical data management platform that gives access Years Fund, Perkins to medical records and automatically downloads and keeps a current Coie, WeiFund, NewDo copy of the dissemination data, enabling healthcare professionals and Venture, Parker companies to track and securely share important medical Conrad, Undisclosed BloomAPI 13-Jul-17 , WA Seed Round data with trusted third parties. 2.40 Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 9 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Developer of an advanced micro-interventional cataract treatment Global Health device designed to deliver energy-free endocapsular lens Investment Fund, IanTech 13-Jul-17 Reno, NV Early Stage VC fragmentation. 4.50 Visionary Venture Fund SV Tech Ventures, Maveron, Correlation Ventures, Band of Angels, Ammunition, WTI, Russell Okung, Oakhouse Partners, Lee Equity Partners, Harald Ludwig, Hadi Partovi, Mehmet Oz, Michael Developer of a heart monitoring device that alerts the user, their Rubin, Ali Partovi, family, and emergency responders upon detection of a life-threatening Mark Burg, Henry iBeat 13-Jul-17 San Francisco, CA Seed Round condition. 6.00 Kravis

Developer of a medical device for treating battlefield wounds and UM Ventures, gel-e 13-Jul-17 College Park, MD Later Stage VC severe hemorrhage. 3.10 Undisclosed Investors Provider of information technology to healthcare workers with Health: ELT 13-Jul-17 Dallas, TX Angel advanced tools for data collection and patient care. 1.69 Undisclosed Investors

Developer of a pediatric medical device for imaging through the PhotoniCare 13-Jul-17 Champaign, IL Angel eardrum for better diagnosis of middle ear ailments and infections. 0.75 Undisclosed Investors Colorado Springs, Provider of contract research laboratory services specializing in GLP Pyxant Labs 13-Jul-17 CO Angel bioanalytical chemistry. 1.10 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 10 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Developer of phototherapy devices for pain relief, tissue repair, and skin cancer imaging scanners using patented technology that uses light and its remittance to view suspicious moles and lesions in a pain-free, non-invasive manner and creates multiple real- time digital images for dermatologists, physicians, and skin specialists to evaluate various Medx Health (MDX) 14-Jul-17 Mississauga, Canada PIPE types of moles or lesions within seconds. 1.08 Undisclosed Investors Keiretsu Capital, Collector and analyzer of saliva samples to provide clinical Keiretsu Forum, ActX 14-Jul-17 Seattle, WA Early Stage VC information to patients and healthcare providers. 3.11 Undisclosed Investors Developer of a drug development platform using machine learning Mayo Clinic, Matrix and artificial intelligence that identifies new uses for existing Capital Management, Qrativ 14-Jul-17 Cambridge, MA Early Stage VC molecules for diseases with unmet medical needs. 8.30 Matrix Partners Developer of a multiparametric fluorescence imaging technology Akoya Biosciences 14-Jul-17 San Francisco, CA Early Stage VC designed to study tissue organization in situ. 9.00 Undisclosed Investors

Endure Capital, Lumia Capital, The Hope Foundation, The Bonnie J. Addario Lung Cancer Foundation, Charlie Cheever, Jared Friedman, Paul Developer of a community platform for physicians intended to help Buchheit, Peter The Mednet 14-Jul-17 New York, NY Seed Round treat patients with cancer. 1.30 Hershberg, Peter Pham

Developer of mitochondrial-derived therapeutics intended to treat age- related diseases, including obesity, fatty liver disease, Type 2 diabetes, CohBar (COB.U) 14-Jul-17 Pasadena, CA PIPE cancer, and cardiovascular and neurodegenerative diseases. 5.16 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 11 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of a web-based telemedicine portal designed for online Qapsula 15-Jul-17 Moscow, Russia Angel communication between patients and doctors. Undisclosed Dmitry Shatalin Secondary Zur Rose Group Frauenfeld, Transaction - Wellington (ROSE) 15-Jul-17 Switzerland Private Provider of online pharmaceutical drugs retail services. Undisclosed Management Group

Aju Pharm, IlDong Holdings Company, Developer of innovative drug therapies for the treatment of diabetes Medici Investment, AntriaBio (ANTB) 17-Jul-17 Louisville, CO PIPE and metabolic diseases. 13.00 Undisclosed Investors Provider of a cloud-based healthcare automation software offering a virtual physician assistant that connects patients to their physicians via B Capital Group, Seven Bright.md 17-Jul-17 Portland, OR Early Stage VC a home computer or mobile device. 8.00 Peaks Ventures

Developer of two medical devices: a controllable, fully visible BRM Capital, Shanghai stentriever designed to treat ischemic stroke patients, and a Israel Investment Fund, controllable aneurysm neck-bridging device to treat peripheral arterial Winnovation, Gefen Rapid Medical 17-Jul-17 Yokneam, Israel Later Stage VC disease. 9.00 Capital Operator of a commercial-stage biopharmaceutical company focused Strongbridge Biopharma on the development and commercialization of therapies for rare (SBBP) 17-Jul-17 Trevose, PA PIPE diseases. 53.00 CRG, Vivo Capital

PE Growth/ General Atlantic, Synaptive 17-Jul-17 Toronto, Canada Expansion Provider of neurosurgical technological products and services. 19.76 Undisclosed Investors

Developer of evolutionary micro-sensor technology to reliably identify biological tissues in contact with the device, providing physicians a Kurma Partners, stroke guidewire to reopen the vessel for each patient and to detect IdInvest Partners, - Sensome 17-Jul-17 Palaiseau, France Seed Round the composition of the blockage in the brain during stroke treatment. 5.27 Saclay Seed Fund

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 12 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Tasly Pharmaceutical Group Company, Operator of a biopharmaceutical drug discovery firm intended to Legend Star, PegBio 17-Jul-17 Suzhou, China Later Stage VC manufacture medical products for diabetes and obesity. 20.00 Undisclosed Investors Developer of imaging agents for cancer diagnosis and therapy that Angiex 17-Jul-17 Cambridge, MA Early Stage VC destroys tumor vessels through vascular targeting. 2.88 Undisclosed Investors Developer of a real-time patient information application designed to IllumiCare 17-Jul-17 Birmingham, AL Angel offer predictive health analytics. 3.72 Undisclosed Investors Developer of a new generation technology that helps in-vitro creation of human tissues and organs in disposable chip-like devices designed Nortis 17-Jul-17 Seattle, WA Angel for the discovery of novel therapies. 0.32 Undisclosed Investors Developer of vital signs monitoring technologies designed to detect Sotera Wireless 17-Jul-17 San Diego, CA Later Stage VC early signs of patient deterioration in any acute care setting. 31.84 Undisclosed Investors Developer and marketer of medical devices to cure pain in bad backs, Zygood 17-Jul-17 Dayton, MD Angel nerve pain from chemotherapy, and arthritic joint pain. 0.38 Undisclosed Investors Capstone Therapeutics Developer of peptides and other molecules intended to help patients (CAPS) 17-Jul-17 Tempe, AZ PIPE with underserved medical conditions. Undisclosed Brookstone GE Ventures, FirstMark Capital, Provider of smart technology-based health insurance services to Aberdare Ventures, Gravie 18-Jul-17 Minneapolis, MN Later Stage VC improve health benefits for employers and consumers. 14.10 Split Rock Partners Norwest Venture Partners and Janus Developer of less-invasive medical devices designed to improve the Henderson Group, treatment of carotid artery disease by protecting the brain from stroke Warburg Pincus, The Silk Road Medical 18-Jul-17 Sunnyvale, CA Later Stage VC throughout the carotid revascularization procedure. 47.00 Vertical Group, CRG Producer of a laboratory developed blood test used as a Chronix Biomedical 18-Jul-17 San Jose, CA Later Stage VC supplementary evaluation to prostate cancer screening. 9.79 Undisclosed Investors Provider of biotechnology data mining services created to develop Hexagon Bio 18-Jul-17 Menlo Park, CA Seed Round drugs for diseases. 8.30 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 13 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Operator of a digital therapeutics company offering fun and engaging video games to improve human nervous system performance in Highmark Interactive 18-Jul-17 Toronto, Canada Seed Round patients with neurological disorders. 2.00 Undisclosed Investors Provider of services and internal research using AI for drug discovery InSilico Medicine 18-Jul-17 Baltimore, MD Early Stage VC and aging research. 6.76 Undisclosed Investors Turnpoint Medical Developer of an infusion pump system for home infusion and cancer Devices 18-Jul-17 Baskin Ridge, NJ Angel clinic markets. 3.28 Undisclosed Investors Provider of a cloud-based healthcare relationship management platform designed to personalize the healthcare experience for hc1.com 18-Jul-17 Indianapolis, IN Later Stage VC providers and the patients they serve. 1.50 Undisclosed Investors

VenBio, Novo Holdings, Rock Springs Capital, Aisling Capital, Bay City Capital, Vivo Developer of serlopitant, a once-daily oral tablet NK-1 receptor Capital, Presidio antagonist, for the treatment of chronic pruritus and chronic cough Partners, Remeditex, F- Menlo Therapeutics 18-Jul-17 Menlo Park, CA Later Stage VC associated with prurigo nodularis. 50.00 Prime Capital PE Growth/ Provider of an online platform designed to help patients book DocASAP 19-Jul-17 Broadlands, VA Expansion appointments with doctors and dentists. 8.58 Cohen Private Ventures

Kaiser Permanente Ventures and F-Prime Capital Partners, Arthur Ventures, LionBird, DreamIt Ventures, Cognosante, TCP Venture Capital, TEDCO, Baltimore Developer of security tools designed to protect patient privacy by Angels, Undisclosed Protenus 19-Jul-17 Baltimore, MD Early Stage VC detecting and preventing data breaches in the electronic health record. 7.00 Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 14 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Life Sciences Partners, Developer of a cervical artificial disc designed to permit the full Sectoral Asset diagnostic imaging capability of MRI imaging and eliminate the need Management, M.H. Simplify Medical 19-Jul-17 Sunnyvale, CA Early Stage VC for CT/Myelogram and CT imaging. 21.00 Carnegie Developer of a highly effective therapy technology that kills cancer tumors with minimal damage to neighboring healthy tissue and is effective against hypoxic tumors, which have great resistance to gamma and beta radiations, enabling the treatment of small tumors Alpha Tau Medical 19-Jul-17 Tel Aviv, Israel Angel and metastatic lesions. Undisclosed Undisclosed Investors Developer of precision-targeted cancer therapies designed to treat Aspyrian Therapeutics 19-Jul-17 San Diego, CA Later Stage VC solid tumors. 15.10 Undisclosed Investors Operator of a medical equipment and supply company intended to Interphase Medical PE Growth/ meet the home medical equipment, supply, and service needs of those Equipment 19-Jul-17 Philadelphia, PA Expansion requiring care in the home. 8.93 Undisclosed Investors Developer of a SaaS platform designed to instantly measure and MuscleSound 19-Jul-17 Glendale, CO Angel analyze glycogen levels. 1.82 Undisclosed Investors Developer of non-invasive neurostimulation devices that induce a Belfast, United Product metabolic shift within the body, leading to a suppressed appetite and Neurovalens 19-Jul-17 Kingdom an increase in fat utilization. Undisclosed Crowdfunding

Developer of a surgical navigation device that can be used in conjunction with magnetic resonance or CT equipment to provide Huayi Capital, National two-dimensional or three-dimensional medical images of the human Emerging Industry body, along with automatic tracking and calibration and images of Guidance Fund, surgical instruments in use, enabling doctors to improve surgical Shandong Buchang planning, get intraoperative guidance, real-time monitoring, Pharmaceuticals, Sangel Symbow Medical 20-Jul-17 Beijing, China Later Stage VC postoperative field effects assessment, and other functions. 17.70 Capital

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 15 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Longtitude Capital, Boston Scientific Corporation, Baird Developer of a medical treatment device using a minimally invasive Capital, F-Primer procedure and cyctoscopic technology to treat female overactive Capital Partners, HBM Amphora Medical 20-Jul-17 Maple Grove, MN Later Stage VC bladder syndrome. 35.50 Healthcare Investments New Enterprise Associates, Lundbeckfonden, Aperture Venture Provider of a clinical development program intended to offer drugs Partners, Omega Funds, Trevi Therapeutics 20-Jul-17 New Haven, CT Later Stage VC for chronic pruritus disease. 50.50 TPG Biotech

OS Fund, Bioeconomy Provider of an enzyme design technology that develops reaction- Capital, Sustainable specific optimized enzymes by creating innovative cell factories that Conversion Ventures, Arzeda 20-Jul-17 Seattle, WA Later Stage VC can transform or supplement current chemical production methods. 12.00 WRF Capital Developer of a phototherapy device for the treatment of patients with Clarify Medical 20-Jul-17 San Diego, CA Early Stage VC psoriasis, vitiligo, and eczema diseases. 3.22 Undisclosed Investors Developer of a reagent-driven technology designed for high-definition Ultivue 20-Jul-17 Cambridge, MA Early Stage VC biological imaging in situ multiplexing. 10.10 Undisclosed Investor

Operator of a gut health and wellness firm focused on restoring internal fitness by a sophisticated test that identifies key small molecules associated with the gut microbiome that are out of balance, and an individualized therapy, enabling individuals to address health Ixcela 20-Jul-17 Bedford, MA Early Stage VC issues such as irritable bowel syndrome, acid reflux, and leaky gut. 1.82 Undisclosed Investors PE Growth/ Developer of medical devices for the treatment of cardiovascular and Nexeon MedSystems 20-Jul-17 Lexington, KY Expansion peripheral vascular diseases. 5.44 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 16 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of surgical devices and non-invasive dry eye products used PE Growth/ for standalone glaucoma procedures or in combination with cataract Sight Sciences 20-Jul-17 Menlo Park, CA Expansion surgery using the same clear corneal incision. 10.00 Undisclosed Investors Provider of a remote medication dispensing management system for Wellfount 20-Jul-17 Indianapolis, IN Later Stage VC long-term care facilities. 11.92 Undisclosed Investors Developer of a wearable health monitoring and emergency alarm system designed to record physiological signals and detect patterns Accelerator/ associated with health-related emergencies while also informing Qolware 20-Jul-17 Munich, Germany Incubator caretakers about such situations. 0.02 Startupbootcamp Provider of a personalized mobile application that controls and København N, Accelerator/ monitors insulin levels in diabetic patients by registering carbohydrate Hedia 20-Jul-17 Denmark Incubator intake and exercise. 0.02 Startupbootcamp

Developer of a medical device designed to help heart disease patients manage their health from home through its artificial intelligence Accelerator/ algorithms and allows physicians to collect information from patients Cardio Cube 20-Jul-17 Warsaw, Poland Incubator and provide them with personalized advice and information. 0.02 Startupbootcamp Accelerator/ Developer of a point-of-care diagnostic machine designed to prescribe Aurora BreakBox 20-Jul-17 Sopot, Poland Incubator appropriate and precise antibiotics. 0.02 Startupbootcamp Developer of a digital health platform using smart sensors that utilize artificial intelligence and machine learning algorithms to provide real Accelerator/ time feedback of rehabilitation patients and adapt exercises according Aisens 20-Jul-17 Poznań, Poland Incubator to the person's progress. 0.02 Startupbootcamp Provider of traditional Chinese medicine developed through Kowloon, Hong proprietary prescriptions for health threats through rigorous scientific MiLOC Group (PPIR) 21-Jul-17 Kong PIPE research and development. 0.22 Undisclosed Investors

IP Group, Woodford Developer of a medical technology designed to offer an unique Investment Tissue Regenix Group Leeds, United approach to regenerative medicine by producing allograft and Management, (TRX) 21-Jul-17 Kingdom PIPE xenograft tissue matricses that retain native structures. 51.16 Undisclosed Investors Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 17 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

MIG Verwaltungs and 1st Capital Partner, S- UBG, WCTI Partners, KfW Bank, HMW Innovations, Seed Fond Aachen, KfW Bank, NRW.BANK.Venture Developer of the ECMO (Extra Corporeal Membrane Oxygenation) Fonds, PB Beteiligung- unit that supports or replaces heart and lung function in the event of und Hemovent 21-Jul-17 Aachen, Germany Early Stage VC cardiac and respiratory failure. Undisclosed Vermoegensverwaltun

The Florida Institute for the Developer of a tunable and reversible linker technology designed to Commercialization of deliver anti-cancer medicines inside the tumor cell and within the Public Research, BlinkBio 21-Jul-17 Jupiter, FL Later Stage VC tumor microenvironment while minimizing toxicities to the patient. 19.14 Undisclosed Investors

Developer of a one-of-a kind sensor and software package that helps users develop and maintain proper computer habits by incorporating the recommended treatment philosophies and recommendations from Eyes4Lives 21-Jul-17 La Habra, CA Angel key eye care professionals and organizations. 2.77 Undisclosed Investors Provider of a transdermal drug delivery system to treat neurological Novopyxis 21-Jul-17 Cambridge, MA Angel disorders. 0.51 Undisclosed Investors Developer of drugs to mitigate gastro-intestinal acute radiation RxBio 21-Jul-17 Johnson City, TN Angel syndrome. 0.34 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 18 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Industrial Innovation Capital Management, Huatai Securities, Developer of next-generation sequencing technology created to detect Boyuanhongsheng, Geneseeq 21-Jul-17 Nanjing, China Later Stage VC cancers and provide healthcare management services. 15.00 Cowin Capital Developer of a diagnostic platform designed for disease management and diagnosis through prognosis from blood samples using liquid BioFluidica 21-Jul-17 Chapel Hill, NC Angel biopsies. 4.14 Undisclosed Investors

Atomico, Eleven Two Provider of health care products designed to digitize each aspect of Capital, The Vertical non-operative preventative care by targeting musculoskeletal disorders Group, Jon Reynolds, Hinge Health 24-Jul-17 San Francisco, CA Early Stage VC using a mobile app, wearable sensors, and personal coaching. 9.57 Undisclosed Investors Investitionsbank des Developer of an online therapy platform offering exercises for the Landes Brandenburg, treatment of neurological defect vision, enabling patients to stimulate BC Brandenburg Caterna Vision 24-Jul-17 Berlin, Germany Later Stage VC the brain and re-establish the connection between brain and eye. Undisclosed Capital

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 19 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Pfizer Venture Investments, Alexandria Venture Investments, U.S. Venture Partners, Abingworth, Novartis Venture Fund, SR One, The Column Group, Altitude Life Science Ventures, Sectoral Asset Management, Abbvie Developer of translation regulators to restore homeostasis to the Biotech Ventures, eFFECTOR protein-synthesis landscape, offering treatment for a variety of serious BioMed Ventures, Therapeutics 24-Jul-17 San Diego, CA Later Stage VC conditions, including cancer. 38.60 Astellas Ventures

NovaScan 24-Jul-17 Milwaukee, WI Later Stage VC Developer of a non-invasive breast cancer detection device. 0.05 Undisclosed Investors Developer of a proprietary medical device with an initial focus on skin Recros Medica 24-Jul-17 San Diego, CA Angel tightening and hair restoration. 4.41 Undisclosed Investors Vietnam Innovative Accelerator/ Provider of an online healthcare service platform designed to Startup Accelerator Dental Cloud 24-Jul-17 Moscow, Russia Incubator automate the joint work of dentists. Undisclosed Program

4490 Ventures, Global Health Sciences (GHS) Fund through Quark Developer of wearable and implantable sensors designed to capture Venture, GF Securities, physiological data for data streaming to understand vital sign patterns LionBird, Undisclosed PhysIQ 25-Jul-17 Naperville, IL Later Stage VC and detect deviations that may indicate a change in health. 8.00 Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 20 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Accelerator and AbbVie Ventures, Alexandria Venture Investments, Eli Lilly and Company, Johnson & Johnson Developer of novel small molecule therapies for the treatment of Innovation, Watson inflammatory bowel disease and the promotion of blood cell Fund, WRF Capital, Rodeo Therapeutics 25-Jul-17 Seattle, WA Early Stage VC reconstitution following bone marrow transplant. 5.90 WuXi AppTec Developer of novel cancer therapeutics designed to spare healthy cells while targeting tumor adaptive responses and cancer evasion Aravive Biologics 25-Jul-17 Houston, TX Later Stage VC pathways. 0.36 Undisclosed Investors

Cormorant Asset Management, Morningside Venture, Cowen Healthcare Investments, Pappas Ventures, Qiming Developer of novel small molecule therapeutics targeting distinct, Venture Partners, Bay fundamental aspects of cellular physiology dealing with protein City Capital, EcoR1 South San homeostasis created to treat autoimmune disorders and malignant Capital, Omega Funds, Kezar Life Sciences 25-Jul-17 Francisco, CA Early Stage VC diseases. 50.00 Aju IB Investment HBM-MedFocus Fund, Developer of medical devices offering state-of-the-art imaging and Invus Group, Wexford Rebound Therapeutics 25-Jul-17 Irvine, CA Early Stage VC illumination technologies for minimally invasive surgery procedures. 16.50 Capital

Developer of an asthma monitoring system using a contactless sensor, Launchpad Digital enabling patients and their families to measure treatment progress and Health, Plug and Play, Tueo Health 25-Jul-17 Redwood City, CA Seed Round outcomes. 1.10 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 21 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Provider of an oncology diagnostics service specializing in histological, UNIM 25-Jul-17 Moscow, Russia Early Stage VC immunohistochemical, and molecular analysis. 2.00 Medme Provider of a platform for online research comparison that allows life science researchers to compare products, share application Monkfish Equity, information, and get access to the biotech kits relevant for their Grazia Equity, ZAGENO 25-Jul-17 Berlin, Germany Early Stage VC research. 7.93 Undisclosed Investors Developer of a potent, self-delivered, and short-acting nasally- Milestone Saint-Laurent, delivered calcium channel antagonist for the episodic treatment of Pappas Ventures, Pharmaceuticals 25-Jul-17 Canada Later Stage VC paroxysmal supraventricular tachycardia, a cardiac arrhythmia. 6.88 Undisclosed Investors Developer of in-vitro diagnostic tests and targeted cancer therapeutics BioAffinity using technology that preferentially targets cancer cells to detect early- Technologies 25-Jul-17 San Antonio, TX Angel stage lung cancer. 4.05 Undisclosed Investors

Versant Ventures, Domain Associates, Accuitive Medical Ventures and Partners Developer of acne treatment technology focused on developing Healthcare Innovation, alternatives to the daily use of topical and systemic drugs currently Salem Partners, available and selectively heat only those skin structures involved in Hercules Capital, Sebacia 25-Jul-17 Duluth, GA Later Stage VC acne. 36.00 Undisclosed Investors US Venture Partners, Members of the Board of Directors of Inceptus Developer of medical devices for the treatment of cardiovascular Medical, Undisclosed Okami Medical 25-Jul-17 Aliso Viejo, CA Early Stage VC diseases. 4.50 Investors Versant Venture Developer of a bio-pharmaceutical platform designed to offer next- Management, generation antibiotics to address multi-drug resistant gram negative Abingworth bacteria, as well as resistant hospital and community bacterial Management, Foresite VenatoRx 25-Jul-17 Malvern, PA Later Stage VC infections. 42.00 Capital Management

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 22 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Provider of a Medicare-approved patient assessment program designed to give physicians and organizations a baseline report Hilton Head Island, detailing modifiable risk factors, preventative goals, and measurable BioAdvance, WellTrackONE 26-Jul-17 SC Early Stage VC data. 2.76 Undisclosed Investors Accelerator/ Developer of chimeric antigen receptor T-cells therapeutics designed Chimera Bioengineering 26-Jul-17 Menlo Park, CA Incubator to treat lymphoblastic leukemia and lymphoma. 0.10 Illumina Accelerator Developer of biotechnology tools designed to track and analyze Accelerator/ genomics composition of human bodies and help better tailor Encompass Bioscience 26-Jul-17 San Francisco, CA Incubator treatment recommendations and guidelines for patients. 0.10 Illumina Accelerator

Developer of therapeutic antibodies for the treatment of cancer and MPM Capital, Aeries other diseases that harness the patient's own immune system to Capital, Affimed destroy tumor cells and their precursors by allowing the antibodies to Therapeutics, EMBL Amphivena bind to target molecules on the surface of tumor cells, T-cells, or NK- Ventures, Undisclosed Therapeutics 26-Jul-17 San Francisco, CA Early Stage VC cells, leading to the breakdown of the cells. 26.50 Investors

New Enterprise Associates and Pfizer Venture Investments, Edmond de Rothschild Investment Partners, Developer of therapies for the treatment of inflammatory and HBM Healthcare Complexa 26-Jul-17 Radnor, PA Later Stage VC metabolic diseases. 62.00 Investments, JAFCO Signature Medical Developer of a medical wearable product using proprietary cloud- Riot Ventures, Bose (Monitoring based audio technology and artificial intelligence that offers remote Ventures and Allied Equipment) 26-Jul-17 Boston, MA Early Stage VC monitoring and evaluation of heart failure. 2.50 Minds Operator of a biopharmaceutical company developing novel antibiotics against infectious diseases, effective treatments for oral mucositis, and proprietary probiotics and health products specifically Oragenics (OGEN) 26-Jul-17 Tampa, FL PIPE designed to enhance oral health of humans and pets. 3.00 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 23 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Operator of a regenerative medicine company developing ground- breaking stromal cell treatments to address some of today's most challenging diseases, including heart disease, arterial disease of the PE Growth/ limbs, diabetes complications, arthritis, and other inflammatory Orbsen Therapeutics 26-Jul-17 Galway, Ireland Expansion conditions. 1.25 Undisclosed Investors PE Growth/ Developer of proteomic technology designed to commercialize life SomaLogic 26-Jul-17 Boulder, CO Expansion science research tools and clinical diagnostic products. 162.97 Undisclosed Investors Developer, manufacturer, and seller of innovative hearing devices, William Demant hearing implants, diagnostic instruments, and personal communication Canada Pension Plan (WDH) 26-Jul-17 Smørum, Denmark PIPE equipment. 0.61 Investment Board Provider of data-based treatment programs intended to help patients Vista Research Group 26-Jul-17 Annapolis, MD Seed Round suffering from mental health disorders. 0.10 TEDCO Developer of novel therapeutics intended to combat leukemia and Teamedon International 26-Jul-17 Rockville, MD Seed Round other related diseases. 0.10 TEDCO

Optikira 26-Jul-17 Cleveland, OH Angel Developer of therapeutics to prevent blindness. 5.30 Undisclosed Investors

Serra Ventures, Keshif Ventures, Hale BioPharma Ventures, Founder.org, Crescent Ridge Partners Developer of a phototherapy device for the treatment of patients with Ventures, Undisclosed Clarify Medical 26-Jul-17 San Diego, CA Seed Round psoriasis, vitiligo, and eczema diseases. 6.48 Investors Prescient Healthcare London, United PE Growth/ Provider of strategic consultancy services to biopharmaceutical Group 27-Jul-17 Kingdom Expansion companies. 19.83 Baird Capital

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 24 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions)

Sanderling Ventures, Arix Bioscience, Fonds de solidarité FTQ, CTI Developer of precision medicines made through the development of Life Sciences and PreciThera 27-Jul-17 Outremont, Canada Early Stage VC innovative biological agents intended to treat orphan diseases. 29.00 Emerillon Capital

Trinity Ventures, Provider of easy-to-use protein structure prediction and protein OrbiMed, SpringRock design software to learn how to use these tools for molecular Ventures, The W Fund, Cyrus Biotechnology 27-Jul-17 Seattle, WA Early Stage VC modeling. 8.00 Undisclosed Investors

High-Tech Gründerfonds, Developer of patented Mimicking Bone Technology created to Mittelständische transform implant surfaces from an artificial barrier into a bone Beteiligungsgesellschaft stimOS 27-Jul-17 Konstanz, Germany Seed Round identic implant body interface. 0.81 Baden-Württemberg Developer of products designed to treat patients suffering from Saba Labs 27-Jul-17 Birmingham, AL Angel complex, chronic, or acute wounds. 0.25 Undisclosed Investors Developer of vision correction technologies designed for the Clerio Vision 27-Jul-17 Rochester, NY Early Stage VC treatment of refractive error. 3.56 Undisclosed Investors Manufacturer and distributor of medical marijuana to treat symptoms Canopy Growth Smiths Falls, such as chronic pain, seizures, muscle spasms, nausea, and loss of (WEED) 27-Jul-17 Canada PIPE appetite. 25.00 Undisclosed Investors

Khosla Ventures, Bold Capital Partners, Peter Provider of wellness as a service using artificial intelligence intended Diamandis, Undisclosed Viome 28-Jul-17 Cupertino, CA Early Stage VC to help people track their microbiome health. 15.00 Investors Developer of a patient empowerment platform created to visualize GAN Ventures, Nicolette 28-Jul-17 , CA Seed Round complex medical data. 0.23 Backstage Capital

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 25 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of clinical grade cardiovascular self-measurement systems targeting the prevention of heart attack and stroke designed to Lexington Biosciences measure and monitor cardiovascular health by assessing the function (LNB) 28-Jul-17 Reno, NV PIPE of a person's vascular endothelium. 0.23 Undisclosed Investors Developer of biotechnical compounds for the healthcare, nutrition, Deinove (ALDEI) 28-Jul-17 Montpellier, France PIPE and cosmetics sectors. 0.56 Truffle Capital

Canadian International West Vancouver, Pharma (CIP.H) 28-Jul-17 Canada PIPE Developer of generic and nutraceutical drugs. 0.17 Undisclosed Investors Developer of immunologically-based disease-specific tests and advanced highly sensitive quantitative platforms used for analyzing BioMedomics 28-Jul-17 Durham, NC Angel cell-based assay procedures. 0.53 Undisclosed Investors

Andreessen Horowitz, Felicis Ventures, AME Cloud Ventures, Pear Ventures, Caffeinated Developer of anti-aging drugs coupling genomics data with machine Capital, Elad Gil, learning, enabling people to combat the suffering and disability caused Farzad Nazem, BioAge Labs 28-Jul-17 Berkeley, CA Early Stage VC by aging-related diseases. 10.90 Undisclosed Investors Manufacturer and provider of medical instruments for cardiovascular Avicena 28-Jul-17 Los Angeles, CA Angel diagnostics and treatments. 2.23 Undisclosed Investors

Boston Harbor Angels, SideCar Angels, UT Astrocyte Developer of CNS drugs designed to protect neurons from stress and Horizon Fund, Pharmaceuticals 28-Jul-17 Cambridge, MA Seed Round trauma after stroke, traumatic brain injury, or concussion. 2.42 Undisclosed Investors Developer of a medical device designed to preserve components of AboGen 28-Jul-17 Portland, ME Angel saliva for medical tests. 0.03 Undisclosed Investors

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 26 Monthly Healthcare Review July 2017 Private Equity Placements and Venture Capital Rounds The following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Last Last Company Name Financing HQ Location Round Description Financing Investor(s) Date Size (Millions) Developer of a predictive care platform that uses passive sensor data from the patient's phone, AI chatbots, and machine learning to suggest medical guidance, and connects patients to physicians and Kae Capital, Touchkin 31-Jul-17 Bengaluru, India Seed Round caregivers. 1.30 Undisclosed Investors Developer of a platform that develops antibiotics by using chemical SOSV, Undisclosed Prospective Research 31-Jul-17 Beverly, MA Seed Round communications to spur Streptomyces bacteria. 0.42 Investors BridgeBio Pharma, The Atlanta Trust, The Developer of skin cancer therapeutics to decrease the number of Montana Trust, The PellePharm 31-Jul-17 Menlo Park, CA Early Stage VC surgically-eligible basal cell carcinomas in Gorlin syndrome patients. 20.00 Piedmont Trust Manufacturer of fully adjustable socket prosthetics created for Lim Innovations 31-Jul-17 San Francisco, CA Angel amputee mobility. 7.93 Undisclosed Investors

Cohen Private PE Growth/ Provider of an online platform designed to help patients book Ventures, Undisclosed DocASAP 31-Jul-17 Broadlands, VA Expansion appointments with doctors and dentists. 8.58 Investors

Developer of a point-of-care screening system designed to detect drug- SpinDiag Undisclosed Freiburg, Germany Early Stage VC resistant bacteria within 30 minutes directly from patient samples. Undisclosed Investiere

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 27 Monthly Healthcare Review July 2017 The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Provider of genetic testing services focused on neurological, cardiological, Asper Biogene Asper Biotech Tartu, Estonia 1-Jul-17 oncological, and hematological services. Undisclosed Litha Healthcare Midrand, South Supplier of devices, consumables, and equipment to public and private hospitals, Acino Group Africa 3-Jul-17 pharmacies, and specialist practitioners. 100.00 Penumbra Crossmed Turin, Italy 3-Jul-17 Distributor of medical supplies and equipment. 9.20

Manufacturer and distributor of medical equipment to simplify diagnosis and Novanta World of Medicine Berlin, Germany 3-Jul-17 facilitate treatment, including cameras, insufflators, medical pumps, and tubing. 129.04 Developer of pharmaceutical products and molecules for the prevention and Invent Farma FB Health Ascoli Piceno, Italy 3-Jul-17 treatment of diseases in the psychiatric, neurologic, and geriatric fields. Undisclosed Developer of therapeutics for patients suffering from atopic dermatitis, such as Spherix Hoth Therapeutics Cincinnati, OH 3-Jul-17 eczema. Undisclosed Pacific Bio-Material Brooks Automation Management Torrance, CA 5-Jul-17 Provider of storage and cold-chain logistics for biological sample materials. 33.00 Cross Country Provider of traveling nurses and staffing for healthcare recruitment services, Healthcare Advantage RN West Chester, OH 5-Jul-17 surgical services, and critical and emergency room services. 88.00

Manufacturer of medical devices in several specialties, including ophthalmology, Katena Products NuPak Medical San Antonio, TX 5-Jul-17 with an ISO 13485-certified and FDA-registered contract manufacturing service. Undisclosed DASA Brasil Previlab Análises Provider of laboratory services, including clinical analysis and pathology laboratory Participações Clínicas Piracicaba, Brazil 5-Jul-17 services. Undisclosed Santa Lucia Pharma Provider of proprietary software, patented robotic technologies, and specialist H.I.G. Capital Apps Gragnanino, Italy 5-Jul-17 support services for drug and medical device management. Undisclosed Lonza Group Capsugel Morristown, NJ 6-Jul-17 Developer and manufacturer of drug delivery systems. 5500.00 Tanntekniker Dentinor Telemark Arnestad Skien, Norway 6-Jul-17 Manufacturer of medical and dental instruments and equipment. Undisclosed Cobalt Light Abingdon, United Agilent Technologies Systems Kingdom 7-Jul-17 Developer of technologies designed to perform non-invasive chemical analysis. 51.16

Rancho Cordova, Developer of instrument systems designed to harvest stem and progenitor cells Cesca Therapeutics SynGen CA 7-Jul-17 from umbilical cord blood, bone marrow, peripheral blood, and cell culture. Undisclosed

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 28 Monthly Healthcare Review July 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions)

Golden Leaf Holdings Chalice Portland, OR 10-Jul-17 Marketer and seller of cannabis flower, edibles, and oils. Undisclosed Integrated Practice Designer and developer of certified innovative chiropractic software technology Waud Capital Partners Solutions San Diego, CA 10-Jul-17 services. Undisclosed Developer and provider of OralCDx, an accurate and non-invasive biopsy to Galen Partners CDx Diagnostics Suffern, NY 11-Jul-17 evaluate common oral lesions and detect pre-cancerous cells. Undisclosed Pan-American Life Provider of a comprehensive Spanish-language health and wellness digital Insurance Company HolaDoctor Roswell, GA 11-Jul-17 networking site. Undisclosed Provider of a SaaS-based system intended to streamline the decision-making process for hospital committees reviewing new products and value analysis TractManager MedApproved Hudson, OH 11-Jul-17 initiatives. Undisclosed Harvest Modern Flower Guadalupe, AZ 11-Jul-17 Operator of a medical marijuana dispensary. Undisclosed Harbor View Medical Regenexx Developer of stem cell treatment network intended to cure patients suffering from Services (Colorado) Broomfield, CO 11-Jul-17 orthopedic problems. Undisclosed Manufacturer and seller of remote cardiac and monitoring diagnostic equipment, providing mobile cardiac telemetry, cardiac event monitoring, and holter BioTelemetry Lifewatch Zug, Switzerland 12-Jul-17 monitoring. 257.00

Constellation (Health Information Technology Med Tech Solutions Business Unit) Minneapolis, MN 12-Jul-17 Developer of healthcare software providing health tech information services. Undisclosed Vierpolders, Developer and manufacturer of ophthalmic products, including disposable micro Beaver-Visitec Vitreq Netherlands 12-Jul-17 forceps and scissors, backflush instruments, and surgical liquids. Undisclosed Global Healthcare Provider of cloud-based technology and services designed to track medical and Temasek Holdings Exchange Louisville, CO 13-Jul-17 surgical supplies. 1800.00 Coastal Life Provider of assembly, packaging, and sterilization services of single-use surgical MedPlast Technologies San Antonio, TX 13-Jul-17 devices. Undisclosed Manufacturer and supplier of pediatric aids intended for children with special AddLife Krabat Hvalstad, Norway 13-Jul-17 needs. Undisclosed

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 29 Monthly Healthcare Review July 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Manufacturer and marketer of active ingredients created for the production of Principia SGR Trifarma Milan, Italy 16-Jul-17 drugs with an emphasis on antibiotics and drugs for the nervous system. 48.09 Developer and marketer of aesthetic medical products designed to offer Apax Partners Syneron Medical Yokneam Illit, Israel 17-Jul-17 nonsurgical cosmetic procedures. 397.00 Operator of a specialty pharmaceutical company intended to acquire and optimize Merus Labs legacy pharmaceuticals and new specialty medicines in a number of therapeutic Norgine International Toronto, Canada 17-Jul-17 categories. 256.44 Provider of information technology consulting services for the healthcare industry Encore Health by advising on how to align strategy, implement systems, apply analytics, and eMids Technologies Resources Houston, TX 17-Jul-17 realize value from clinical data. Undisclosed

Malta Informatique AXigate Paris, France 18-Jul-17 Developer of a health information system designed to ensure patient follow-up. Undisclosed Operator of a laboratory-based healthcare consulting company that provides spectrum diagnostics across the continuum of care in oncology, women's health, Quest Diagnostics Med Fusion Lewisville, TX 18-Jul-17 and urology. Undisclosed TomTec Imaging Unterschleissheim, Developer of intelligent image analysis software, including multimodality, vendor Philips Systems Germany 18-Jul-17 neutral imaging, and analysis for cardiology and radiology. Undisclosed Manufacturer of in-vitro diagnostic products, including proprietary digestion, decontamination, neutralization, and other sample preparation products, for StoneCalibre Alpha-Tec Systems Vancouver, WA 19-Jul-17 mycobacteria diagnostics. Undisclosed Designer, manufacturer, and validator of multi-cavity injection molds created to Avenue Mould be used for high volume applications in the medical device and pharmaceutical GW Plastic Solutions Sligo, Ireland 19-Jul-17 industry. Undisclosed Developer of nanoparticle-drug conjugates designed to selectively attack tumor Daré Bioscience Cerulean Pharma Waltham, MA 19-Jul-17 cells and reduce toxicity by sparing the body's normal cells. Undisclosed Developer of a cloud-based software as a service healthcare platform for home Netsmart Technologies DeVero San Jose, CA 19-Jul-17 health care, hospice, pediatric, and therapy group industries. Undisclosed Enplas PolyLinks Asheville, NC 19-Jul-17 Manufacturer of injection molding, including laboratory slides. Undisclosed

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 30 Monthly Healthcare Review July 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions)

Distributor of ancillary medical supplies partnered with ambulatory clinic Ridgemont Equity customers to increase operational excellence in the ordering, usage, delivery, and Partners HemaSource West Jordan, UT 20-Jul-17 storage of medical products in plasma protein collections and dialysis services. Undisclosed Melbourne, Developer of a novel nasal spray intended to treat acquired hearing loss in Auris Medical Otifex Therapeutics Australia 20-Jul-17 children. Undisclosed Manufacturer of positive-displacement piston pumps used primarily in analytical and diagnostic instrumentation, such as high performance liquid chromatography Teledyne Instruments Scientific Systems State College, PA 20-Jul-17 systems and specific medical devices. Undisclosed Developer of regenerative matrices and graft products dedicated to the development of innovative osteoinductive and wound care scaffolds that enhance Tissue Regenix Group CellRight Universal City, TX 21-Jul-17 healing opportunities of defects created by trauma and disease. 29.42 GED Vitro Sevilla, Spain 21-Jul-17 Manufacturer of equipment, reagents, and software for in-vitro diagnostics. Undisclosed Biochemical Systems Star Capital International Arezzo, Italy 21-Jul-17 Provider of biochemical research products intended for liquid and dry chemistry. Undisclosed Manufacturer of medical devices, including incubators, warmers, procedural beds, neonatal transporters, photo-therapy products, resuscitation products, and Flexicare Neoforce Group Ivyland, PA 24-Jul-17 incubator drawers. 0.72 Developer of a novel class of disease modifying therapies designed to preserve Alpine Immune Nivalis intracellular GSNO, an endogenous molecule with cell signaling effects that are Sciences Therapeutics Boulder, CO 24-Jul-17 implicated in the pathophysiology of cystic fibrosis. 90.00 Developer and manufacturer of a range of pharmaceutical products and medical devices based on a proprietary collagen-based technology for the treatment of Gurnet Point Capital Innocoll Athlone, Ireland 24-Jul-17 post-operative pain and diabetic foot infections. 209.00 Jean-Pascal Peyret @-Health France 24-Jul-17 Provider of cardiovascular monitoring and diagnostic services. Undisclosed Zavation Medical Manufacturer of a range of spinal hardware covering key areas, including LongueVue Capital Products Flowood, MS 25-Jul-17 thoracolumbar, cervical, interbody fusion, and minimally invasive surgeries. Undisclosed Genesis Medical London, United Distributor of medical products intended to provide reliable diagnostic products Cogentix Medical (London) Kingdom 26-Jul-17 and medical equipment for the urology and gynecology fields. 0.66

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 31 Monthly Healthcare Review July 2017 Mergers and Acquisitions The following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Transaction Acquirer Target HQ Location Date Description Value (Millions) Essential Developer of organ preservation products and provider of research facilities to Accord Healthcare Pharmaceuticals Ewing, NJ 26-Jul-17 surgeons and bio-pharmaceutical companies. Undisclosed Monteggio, Provider of micronization services and equipment intended to improve active Lonza Group Micro-Macinazione Switzerland 26-Jul-17 pharmaceutical ingredients. Undisclosed Baxter International Claris Injectables NJ 27-Jul-17 Developer of injectable drugs and pharmaceuticals. 625.00 Constance, Provider of DNA and RNA sequencing and bioinformatics services to academic Eurofins Scientific GATC Biotech Germany 27-Jul-17 and industrial customers. Undisclosed

Medtronic (Medical Provider of medical supplies, including diabetes products, insulin pumps, health Cardinal Health Supplies Business) Dublin, Ireland 30-Jul-17 and fitness products, and glucose monitoring products. 6100.00 Manufacturer of electrically operated healthcare beds and other healthcare CoBe Capital Völker (Witten) Witten, Germany 31-Jul-17 furnishings. Undisclosed Operator of a leading medical contract manufacturing company specializing in the Sant'Antonino, production of forged medical products like joint implants, anatomical trauma Marle SMB Medical Switzerland 31-Jul-17 products, and medical instruments. Undisclosed Philips (Sonalleve Amsterdam, Distributor of sonalleve devices used to ablate uterine fibroids and palliative pain Profound Medical MR-HIFU) Netherlands 31-Jul-17 treatment of bone metastases. 6.07 Oceania Manufacturer of orthopedic products, including a mobile bearing tibia, hip LifeHealthcare Group Orthopaedics Albion, Australia 31-Jul-17 implants, knee replacement products, and elbow joints. 7.24

Napo Provider of Mytesi, an antidiarrheal indicated for the symptomatic relief of Jaguar Health Pharmaceuticals San Francisco, CA 31-Jul-17 noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy. Undisclosed Developer of adenosine-based pharmaceutical products to treat autoimmune Lewis & Clark diseases that have molecular properties offering enhanced distribution in tissue Inspyr Therapeutics Pharmaceuticals Charlottesville, VA 31-Jul-17 and penetration of human skin. Undisclosed

Source: Pitchbook Compiled by: Lea Keller and Morgan Reape 32