DOCSLIB.ORG

Vol. 30, Issue 1/2003

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Vol. 30, Issue 1/2003 PL ISSN 0324-833X POLSKIE TOWARZYSTWO ANATOMICZNE POLSKIE TOWARZYSTWO BIOLOGII KOMÓRKI POLISH ANATOMICAL SOCIETY POLISH SOCIETY FOR CELL BIOLOGY VOL. 30, ISSUE 1/2003 (1- 216) www.pbkom.pl http://rcin.org.pl POSTĘPY BIOLOGII KOMÓRKI TOM 30, 2003 NR 1 (1-216) ADVANCES IN CELL BIOLOGY VOL. 30, 2003 NR 1 (1-216) Kwartalnik Polskiego Towarzystwa Anatomicznego, Polskiego Towarzystwa Biologii Komórki, Pol­ skiej Sieci UNESCO oraz Fundacji Biologii Komórki i Biologii Molekularnej wydawany z częściową pomocą finansową Komitetu Badań Naukowych. Quarterly of the Polish Anatomical Society, the Polish Society of Cell Biology, the Polish UNESCO Net, and the Foundation for Cell Biology and Molecular Biology, partialy supported by the Committee for Scientific Research (KBN) Redaguje K olegium - Editors: Szczepan BILIŃSKI - biologia rozwoju, embriologia, cytoszkielet, połączenia międzykomórkowe - developmental biology, embryology, cytoskeleton, cell junctions - Inst. Zoologii UJ, 30-060 Kraków, Ingardena 6 Lilia HRYNIEWIECKA - energetyka komórki, mitochondria - cell energetics, mitochondria - Zakład Bioenergetyki, Uniwersytetu im. A. Mickiewicza, 61-701 Poznań, ul. Frediy 10 Bożena KAMIŃSKA - neurobiologia, biologia molekularna - neurobiology, molecular biology - Instytut Biologii Doświadczalnej im. M. Nenckiego 02-097 Warszawa, ul. Pasteura 3 Jerzy KAWIAK - immunologia, cytometria, hematologia, biologia nowotworów - immunology, cyto­ metry, hematology, cancer biology - Zakład Cytologii Klinicznej CMKP, 01-813 Warszawa, ul. Mary- moncka 99 Wincenty KILARSKI - mięśnie, skurcz mięśniowy, ruchy komórek - muscles, muscle conctraction, cell m ovem ents - Instytut Zoologii UJ, 30-060 Kraków, ul. Ingardena 6 Maria OLSZEWSKA - komórki roślinne, informacja genetyczna w komórkach roślinnych i zwierzę­ cych - plant cells, genetic information in plant and animal cells - Zakład Cytologii i Cytochemii Roślin Instytutu Fizjologii i Cytologii UŁ, 90-237Łódź, ul. Banacha 12/16 Barbara PŁYTYCZ- immunologia- immunology- Instytut Zoologii UJ, 30-060 Kraków, ul.Ingardenaó Maciej ZABEL-histologia ogólna, endokrynologia, histochemia (immunocytochemia, hybrydocytoche- mia), ultrastruktura kom órek-histology, endocrinology, histochemistry (immunocytochemistry, hybry- docytochemistry), celi ultrastructure-Zakład Histologii AM, 50-368 Wroclw, ul.Chałubińskiego 6a Jan ŻEROMSKI - patologia, immunologia, cytometria - pathology, immunology, cytometry - Katedra i Zakład Im m unologii A M 60-355 Poznań, ul. Przybyszewskiego 49 Rada Redakcyjna - Advisory Board: Zofia OSUCHOWSKA - przewodnicząca, Mieczysław CHORĄŻY, Leszek CIECIURA, Antoni HORST, Aleksander KOJ, Włodzimierz KOROHODA, Leszek KUŹNICKI, Olgierd NARKIEWICZ, Aleksandra PRZEŁĘCKA, Aleksandra STOJAŁOWSKA, Lech WOJTCZAK Adres Redakcji - Editorial Office: Centrum Medyczne Kształcenia Podyplomowego, ul. Marymoncka 99,01-813 Warszawa, Poland, tel. 8340 344, fax 8340470, e-mail: [email protected]._____________________________________________ @ Fundacja Biologii Komórki i Biologii Molekularnej - Foundation for Cell Biology and Molecular Biology Wszystkie prawa zastrzeżone. Zabrania się kopiowania części lub całości bez uprzedniego pisemnego zezwolenia Fundacji Biologii Komórki i Biologii Molekularnej. All rights reserved. No part o f this publication may be reproduced in any form or by any means without the prior written permission o f the publisher. Requests to the publisherfor permission should be adressed to the Fundacja Biologii Komórki i Biologii Molekularnej. Ark. wyd. 18,0. Ark. druk. 13,75. Podpisano do druku w grudniu 2002 r. Druk ukończono w styczniu 2003 r. http://rcin.org.pl W TYM ZESZYCIE PBK Wyciszanie RNA jest procesem, w którym dochodzi do degradacji w ko­ mórkach roślin wybranych cząsteczek RNA. Mechanizm ten odgrywa klu­ czową rolę w dwóch niezwykle ważnych dla roślin procesach: w potran- skrypcyjnej regulacji ekspresji genów i w obronie roślin przed infekcją wi­ rusów. W identyfikacji właściwych do degradacji cząsteczek RNA biorą udział krótkie fragmenty RNA o długości 21-25 nukleotyów oraz roślinna rybonukleaza. Więcej na ten temat znajdzie Czytelnik na stronie 75 tego Zeszytu. Na stronie 167-186 sądyskutowane DNA i białka centromerowe. Wspól­ ną cechą dotąd zbadanych DNA centromerowych jest obecność układów tandemowych. Pewne ogólne podobieństwo sekwencji centromerowego DNA stwierdza się w rzędzie naczelnych, a także u spokrewnionych gatunków roślin wyższych. Kaspazy są egzekutorami procesu programowanej śmierci komórki. Za opisanie regulacji genetycznej tego]brocesu Nagrodę Nobla z Fizjologii i Medycyny w roku 2002 otrzymali Sydney Brenner, Robert Horovitz i John E. Sulston. Może również dlatego warto zajrzeć na stronę 129 tego ze­ szytu, gdzie podsumowano osiągnięcia badań nad mechanizmami akty­ wacji, głównymi substratami kaspaz i regulacją ich aktywności.. Komórki wątroby pełnią różne funkcje, co wiąże się też z ich lokalizacją. Na stronie 47 rozpoczyna się dwuczęściowy artykuł o roli komórek gwiaź­ dzistych w regulacji funkcji wątroby. http://rcin.org.pl WYKAZ RECENZENTÓW Z TOMU 29 Z ROKU 2002 REFEREES OF THE VOLUME 29, 2002 Prof. dr hab. Lucyna Antkiewicz-MichalukProf. dr hab. Jolanta Matuszyńska Prof. dr hab. Szczepn Biliński Prof. dr hab. Jerzy Nowak Prof. dr hab. Zofia Błach-Olszewska Prof. dr hab. Maria Olszewska Prof. dr hab. Maria Charzyńska Prof. dr hab. Regina Osiecka Prof. dr hab. Mieczysław Chrąży Prof. dr hab. Zofia Osuchowska Prof. dr hab. Andrzej Dżugaj Prof. dr hab. Barbara Płytycz Prof. dr hab. Anna Goździcka-Józefiak Prof. dr hab. Lech Ratajczak Prof. dr hab. Mirosława Furmanowa Prof. dr hab. Danuta Rożynkowa dr Grażyna Hoser Doc. dr hab. Bogusław Sawicki Prof. dr hab. L. Hryniewiecka Prof. dr hab. J. Selmaj Prof. dr hab. Danuta Hulanicka Prof. dr hab. Ryszard Słomski Prof. dr hab. Krystyna Janas Prof. dr hab. Jerzy Stachura Prof. dr hab. Józef Kałuża Prof. dr hab. Zofia Starek Prof. dr hab. Jerzy Kawiak Prof. dr hab. Piotr Stępień Prof. dr hab. Andrzej K. Konowonicz Doc. dr hab. Tomasz Stokłosa dr Anna Korzyńska Prof. dr hab. Kazimierz Strzałka Prof. dr hab. Zbigniew Krupa Prof. dr hab. Adam Szewczyk Prof. dr hab. Halina Krzanowska Prof. dr hab. Irena Szumiel Prof. dr hab. Anna Latos-Bieleńska Prof. dr hab. Maciej Ugorski Prof. dr hab. Stanisław Lewak Prof. dr hab. Maciej Zabel Prof. dr hab. Jerzy Liebhart Prof. dr hab. Jan Żeromski Prof. dr hab. Maria Malicka-Błaszkiewicz http://rcin.org.pl POSTĘPY BIOLOGII KOMÓRKI TOM 30 2003 NR 1 (3-8) PROFESOR MIROSŁAW MOSSAKOWSKI: NEUROBIOLOG - INTUICJONISTA I WIZJONER WSPOMNIENIE IN MEMORIAM: PROFESSOR MIROSŁAW MOSSAKOWSKI A NEUROBIOLOGIST WITH INTUITION AND VISION Jan ALBRECHT Zakład Neurotoksykologii, Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego PAN, Warszawa Streszczenie: Niniejszy artykuł poświęcony jest osiągnięciom naukowym Profesora Mirosława Mossa­ kowskiego, zmarłego rok temu wybitnego neurobiologa-neuropatologa, wieloletniego dyrektora Cen­ trum Medycyny Doświadczalnej i Klinicznej Polskiej Akademii Nauk, od 1998 r. do chwili śmierci Prezesa Polskiej Akademii Nauk. Przytoczone fakty z życia naukowego Profesora, uzupełnione reflek­ sjami z kontaktów osobistych oraz odniesieniami do aktualnego stanu wiedzy w dziedzinach zaintere­ sowania Profesora, a na tym tle osiągnięć badawczych Jego uczniów, dokumentują Jego niezwykłą intuicję naukową, a szczególnie dar przewidywania przyszłościowych kierunków badań nad fizjologią i patologią mózgu. Słowa kluczowe: mózg, astrocyty, niedokrwienie, niedotlenienie, encefalopatia wątrobową, biosynteza białek. Summary.Thz present paper is devoted to the scientific achievements of Professor Mirosław Mossa­ kowski, a leading figure in neuropathology and neuroscience who passed away a year ago. Professor Mossakowski was Director of the Medical Research Centre of the Polish Academy of Sciences for more than a quarter of a century, and held the post of a President of the Academy from 1998 until his last days. Facts from his professional life are presented in the context of the up-to-date state of the art of the areas of his interest and of the achievements of his scholars, and painted with the authors’ experiences derived from the personal contacts with his mentor. The treatise is aimed at documenting Prof. Mossakowski’s extraordinary intuition in various areas of neurobiology, in particular his gift to foresee the future lines of research on the physiology and pathology of the central nervous system. K ey w o rd s: brain, astrocytes, ischemia, hypoxia, hepatic encephalopathy, protein biosynthesis. http://rcin.org.pl 4 J. ALBRECHT W dniu 26 grudnia ubiegłego roku odszedł Profesor Mirosław Mossakowski. Był wybitnym neurobiologiem, jednym z rzadkich w dzisiejszych czasach przedstawicieli społeczności naukowej, których najkrótsza charakterystyka mieści się w pełni w sformułowaniu „postać renesansowa”. W czasach, gdy skuteczność drogi życiowej utożsamia się z zawężaniem i skracaniem szlaków ekspansji i pola widzenia, Profesor jako jeden z nielicznych łączył w sobie cechy wybitnego uczonego, organizatora i animatora nauki, menedżera i męża stanu. W ogólnej świadomości społecznej najsilniej zaakcentowały się jego rozliczne funkcje animacyjno-kierownicze. Przez ponad 25 lat był dyrektorem Centrum Medycyny Doświadczalnej i Klinicznej PAN - instytutu, który stworzył od podstaw i który w maju br. został na Jego cześć przemianowany na Instytut Medycyny Doświadczalnej i Klinicznej im. M. Mossakowskiego. Od przeszło 20 lat pełnił wysokie funkcje w Polskiej Akademii Nauk: od 1998 r. do
Load more

Recommended publications
  • Classical Liver (Hepatic) Lobules It Is Formed of a Polygonal Mass of A- Capsule: Glisson’S Capsule
    LIVER & SPLEEN Color index: Slides.. Important ..Notes ..Extra.. Objectives: By the end of this lecture, the student should be able to describe: 1. The histological structure of liver with special emphasis on: . Classical hepatic (liver) lobule. Hepatocytes. Portal tract (portal area). Hepatic (liver) blood sinusoids. Space of Disse (perisinusoidal space of Disse) . Bile canalculi. 2. The histological structure of spleen with special emphasis on: . White pulp. Red Pulp. LIVER 1-Stroma; 2-Parenchyma; mainly C.T, but not in humans. Classical liver (hepatic) lobules It is formed of a polygonal mass of a- Capsule: Glisson’s Capsule. liver tissue, bounded by b- Septa (absent in human) interlobular septa with portal areas & Portal areas (Portal tracts) at the periphery & central Portal area: surrounded by (centrolobular) vein in the center. other structures. Central vein: surrounded by c- Network of reticular fibers. hepatocytes LIVER Contents of the Classic Liver Lobule: Borders of the Classical Liver Lobule the rows of hepatocytes should be next to each other; 1- Septa: C.T. septa (e.g. in pigs). remember canaliculi 2- Portal areas (Portal tracts): 1- Anastomosing plates of hepatocytes. Are located in the corners of the classical hepatic 2- Liver blood sinusoids (hepatic blood lobule (usually 3 in No.). sinusoids): between the plates. Contents of portal area: 3- Spaces of Disse (perisinusoidal spaces of a- C.T. b- Bile ducts (interlobular bile ducts). Disse) between the hepatocytes and sinusoids c- Venule (Branch of portal vein). 4- Central vein. d- Arteriole (Branch of hepatic artery). 5- Bile canaliculi. Hepatic artery: surrounded by smooth muscles while the bile duct is not.
    [Show full text]
  • Nomina Histologica Veterinaria, First Edition
    NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria.
    [Show full text]
  • Junction Between Kupffer Cells and Hepatic Sinusoidal Endothelium. a Review This Short Review Was Prepared on the Basis of Trans
    Okajimas Folia Anat. Jpn., 57(2-3) : 145-158, August 1980 Junction between Kupffer Cells and Hepatic Sinusoidal Endothelium. A Review By TOSHIO ITO, YUTAKA TANUMA and SUSUMU SHIBASAKI Department of Anatomy, Teikyo University School of Medicine, Tokyo 173 and Department of Anatomy, Gunma University School of Medicine, Maebashi 371, Japan -Received for Publication, January 24, 1980- Key Words : Kupffer-endothelial junction, Human and bat liver, TEM and SEM. Summary. In this review, the junctions between Kupffer and sinusoidal endothelial cells previously revealed by the present authors under the transmission electron microscope in both normal human and bat livers has been discussed and compared with stereo- images of the connections between the two cell types reported by other authors in scanning electron microscopic studies. It is concluded that Kupffer cells lie on the gap or opening of the endothelial lining of the sinusoid, that part of the perisinusoidal surface of the cell body which is applied to the opening directly faces the perisinusoidal space, and that the margin of this part of the perisinusoidal surface of the Kupffer cell and the margin of the endothelial opening are circularly bound by means of a peculiar close junctional area identical in structure and appearance with the so-called "junctional complex" (Wisse) between endothelial cells . The two junctional areas between the Kupffer cell and the endothelial sheet which are found in a pair in trans- mission electron microscopic preparations on two diametrical parts of the perisinusoidal surface of the Kupffer cell, should be derived from the perpendicular section of such a circular margin of the endothelial opening attached to the Kupffer cell body.
    [Show full text]
  • (Hepatic Stellate Cells) in Diagnosis of Liver Fibrosis
    Gastroenterology & Hepatology: Open Access Research Article Open Access Ito stellate cells (hepatic stellate cells) in diagnosis of liver fibrosis Introduction Volume 10 Issue 4 - 2019 Adverse outcome of most chronic diffuse liver lesions of various etiologies including chronic hepatitis C (CHC) is liver fibrosis in the Vladimir Tsyrkunov,1 Viktor Andreev,2 Rimma development of which main participants are activated fibroblasts. Kravchuk,3 Iryna Kаndratovich1 Activated hepatic stellate cells (HSC) are the main source of activated 1 1,2 Department of Infectious Diseases, Grodno State Medical fibroblasts. University, Belarus 2 HSC, a synonym - stellate cells of liver, Ito cells, perisinusoidal Department of Histology, Grodno State Medical University, Belarus lipocytes, stellate cells. HSC were firstly described in 1876 and named 3Department of Science, Grodno State Medical University, by K. Kupffer stellate cells T. Ito, finding in them a drop of fat firstly Belarus marked them as lipophagic («shibo-sesshusaibo») but then finding that the fat elaborated by the cells from glycogen named them as Correspondence: Iryna Kаndratovich, Department of fat-storing cells or Ito sells («shibo-chozosaibo»).3 In 1971, K.Wake Infectious Diseases, Grodno State Medical University, Gorkogo str 80, Grodno 230009, Belarus, Tel +375152434286, Fax proved the identity of stellate cells of Kupffer and Ito cells and that +375152434286, Email these cells are “stored” vitamin A.4 Received: October 29, 2018 | Published: July 25, 2019 About 80% of vitamin A which is in the body accumulates in the liver and up to 80% of liver retinoids deposited in fat droplets of HSC. Ethers of retinol in formulation of chylomicrons entered to Methods hepatocytes, where they are converted to retinol and form of vitamin A complex with retinol binding protein (RBP), which is secreted in Lifetime liver biopsy obtained by performing aspiration biopsy perisinusoidal space where it deposited by cells.5 of the liver of patients with CHC (HCV ribonucleic acid+).
    [Show full text]
  • Dystroglycan Expression in Hepatic Stellate Cells: Role in Liver Fibrosis
    0023-6837/02/8208-1053$03.00/0 LABORATORY INVESTIGATION Vol. 82, No. 8, p. 1053, 2002 Copyright © 2002 by The United States and Canadian Academy of Pathology, Inc. Printed in U.S.A. Dystroglycan Expression in Hepatic Stellate Cells: Role in Liver Fibrosis Pierre Bedossa, Sophie Ferlicot, Valérie Paradis, Delphine Dargère, Frank Bonvoust, and Michel Vidaud Service d’Anatomie Pathologique (PB, SF, VP), Hôpital de Bicêtre, Université Paris Sud, UPRESA CNRS-8O67 (PB, VP, DD, FB), Faculté des Sciences Pharmaceutiques, Université Paris VI, and JE DRED 351 (MV), Laboratoire de Génétique Moléculaire, Faculté de Pharmacie, Paris, France SUMMARY: Dystroglycan is a membrane component of the dystrophin-glycoprotein transmembrane complex. Its expression is required for the spatial organization of laminin on the cell surface and for basement membrane assembly. In view of the constitution of a perisinusoidal basement membrane during liver fibrosis, we studied dystroglycan expression in liver fibrosis. Dystroglycan mRNA and protein expression were investigated by immunofluorescence, Western blot, and quantitative RT-PCR (TaqMan) in normal human and rat liver and in isolated rat hepatic stellate cells. On Western blot, a 43-kd band corresponding to ␤-dystroglycan was observed in protein extracted from normal and fibrotic human and rat livers. The specific 43-kd protein was also detected in lysates from rat hepatic stellate cells but not from hepatocytes. By immunofluorescence, patchy deposits of ␤-dystroglycan were detected on membrane of hepatic stellate cells in culture. On Western blot and quantitative RT-PCR, an up-regulation of ␤-dystroglycan was shown during spontaneous activation of hepatic stellate cells in culture. Direct evidence for the role of dystroglycan in laminin-hepatic stellate cell interaction was shown because specific antibody directed against ␣-dystroglycan inhibited partially hepatic stellate cell adhesion on laminin-coated plates.
    [Show full text]
  • Liver, Gallbladder, and Pancreas
    Digestive system III: Liver, Gallbladder, And Pancreas Liver Introduction - The embryology , gross morphology , and histology of the normal human liver ”the single largest organ in the human body ”are described in this chapter . - In many instances, immunohistologic studies of liver tissue have the potential to yield more information than electron microscopy. Embryology - The liver arises as the hepatic diverticulum from the endodermal lining of the most distal portion of the foregut during the 3 to 5 week of gestation. - In embryos 4 to 5 mm in length. - The hepatic diverticulum differentiates cranially into proliferating hepatic cords and caudally into the gallbladder and extrahepatic bile ducts. - The anastomosing cords of hepatic epithelial cells grow into the mesenchyme of the septum transversum. - As the hepatic cords extend outward during the 5 week of gestation, they are interpenetrated by the inwardly growing capillary plexus, which arises from the vitelline veins in the outer margins of the septum transversum and forms the primitive hepatic sinusoids. - Scattered mesenchymal cells lie between the endothelial wall of the sinusoids and the hepatic cords and form the hepatic stroma, as well as the capsule. - Hematopoietic tissue and Kupffer cells also derive from splanchnic mesenchyme, begins during the 6 week. - By 9 weeks' gestation accounts for approximately 10% of the total weight of the embryo. - The bile canaliculi appear in the 10-mm embryo (9weeks) as intercellular spaces between immature hepatocytes (hepatoblasts). - The epithelium of the intrahepatic bile ducts arises from the proximal part of the primitive hepatic cords. - the epithelial layer in direct contact with the mesenchyme around the portal vein transforms into bile duct “type cells.
    [Show full text]
  • 26 April 2010 TE Prepublication Page 1 Nomina Generalia General Terms
    26 April 2010 TE PrePublication Page 1 Nomina generalia General terms E1.0.0.0.0.0.1 Modus reproductionis Reproductive mode E1.0.0.0.0.0.2 Reproductio sexualis Sexual reproduction E1.0.0.0.0.0.3 Viviparitas Viviparity E1.0.0.0.0.0.4 Heterogamia Heterogamy E1.0.0.0.0.0.5 Endogamia Endogamy E1.0.0.0.0.0.6 Sequentia reproductionis Reproductive sequence E1.0.0.0.0.0.7 Ovulatio Ovulation E1.0.0.0.0.0.8 Erectio Erection E1.0.0.0.0.0.9 Coitus Coitus; Sexual intercourse E1.0.0.0.0.0.10 Ejaculatio1 Ejaculation E1.0.0.0.0.0.11 Emissio Emission E1.0.0.0.0.0.12 Ejaculatio vera Ejaculation proper E1.0.0.0.0.0.13 Semen Semen; Ejaculate E1.0.0.0.0.0.14 Inseminatio Insemination E1.0.0.0.0.0.15 Fertilisatio Fertilization E1.0.0.0.0.0.16 Fecundatio Fecundation; Impregnation E1.0.0.0.0.0.17 Superfecundatio Superfecundation E1.0.0.0.0.0.18 Superimpregnatio Superimpregnation E1.0.0.0.0.0.19 Superfetatio Superfetation E1.0.0.0.0.0.20 Ontogenesis Ontogeny E1.0.0.0.0.0.21 Ontogenesis praenatalis Prenatal ontogeny E1.0.0.0.0.0.22 Tempus praenatale; Tempus gestationis Prenatal period; Gestation period E1.0.0.0.0.0.23 Vita praenatalis Prenatal life E1.0.0.0.0.0.24 Vita intrauterina Intra-uterine life E1.0.0.0.0.0.25 Embryogenesis2 Embryogenesis; Embryogeny E1.0.0.0.0.0.26 Fetogenesis3 Fetogenesis E1.0.0.0.0.0.27 Tempus natale Birth period E1.0.0.0.0.0.28 Ontogenesis postnatalis Postnatal ontogeny E1.0.0.0.0.0.29 Vita postnatalis Postnatal life E1.0.1.0.0.0.1 Mensurae embryonicae et fetales4 Embryonic and fetal measurements E1.0.1.0.0.0.2 Aetas a fecundatione5 Fertilization
    [Show full text]
  • Digestive Glands
    Digestive glands Department of Histology and Embryology of Jilin university ----Jiang Wenhua 1.general description of digestive glands Small digestive glands oesophageal glands gastric glands pyloric glands intestinal glands large digestive glands salivary glands pancreas liver Function: excretion digestive juice incretion 2 salivary glands 2.1.The General Structure of Salivary Glands being composed of acinus and duct striated ducts mucous acinus intercalated ducts serous acinus serous demilune Schematic drawing of the structure of Salivary Glands 2.1.1 acinus (1) serous acinus (2) mucous acinus (3) mixed acinus serous acinus • Serous cells are usually pyramidal in shape, with a broad base and a narrow apical surface .They exhibit characteristics of protein-secreting cells. Adjacent secretory cells are joined together and usually form a spherical mass of cells called acinus, with a lumen in the center . striated ducts mucous acinus intercalated ducts serous acinus serous demilune Schematic drawing of the structure of Salivary Glands mucous cells Mucous cells are usually cuboidal to columnar in shape; their nuclei are oval and pressed toward the bases of the cells. They exhibit the characteristics of mucus-secreting cells , containing glycoproteins important for the moistening and lubricating functions of the saliva. striated ducts mucous acinus intercalated ducts serous acinus serous demilune Schematic drawing of the structure of Salivary Glands The cytoplasm stains lighter in an H and E preparation.large mucigen granules are present
    [Show full text]
  • The Space of Disse: the Liver Hub in Health and Disease
    Review The Space of Disse: The Liver Hub in Health and Disease Carlos Sanz-García 1 , Anabel Fernández-Iglesias 2,3 , Jordi Gracia-Sancho 2,3,4 , Luis Alfonso Arráez-Aybar 5 , Yulia A. Nevzorova 1,6,7 and Francisco Javier Cubero 1,7,* 1 Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain; [email protected] (C.S.-G.); [email protected] (Y.A.N.) 2 Liver Vascular Biology Research Group, IDIBAPS, 08036 Barcelona, Spain; [email protected] (A.F.-I.); [email protected] (J.G.-S.) 3 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain 4 Hepatology, Department of Biomedical Research, University of Bern, 3012 Bern, Switzerland 5 Department of Anatomy and Embriology, Complutense University School of Medicine, 28040 Madrid, Spain; [email protected] 6 Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany 7 12 de Octubre Health Research Institute (imas12), 28040 Madrid, Spain * Correspondence: [email protected]; Tel.: +34-394-1385 Received: 13 December 2020; Accepted: 25 January 2021; Published: 3 February 2021 Abstract: Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between the endothelial cells and hepatocytes filled with blood plasma, have acquired great importance in liver disease. The space of Disse is home for the hepatic stellate cells (HSCs), the major fibrogenic players in the liver. Quiescent HSCs (qHSCs) store vitamin A, and upon activation they lose their retinol reservoir and become activated.
    [Show full text]
  • The Kupffer Cell
    DICTIONARY OF NORMAL CELLS THE KUPFFER CELL Raluca Amalia Ceausu1 1 Department of Microscopic Morphology Morphology/Histology, Angiogenesis Research Center Timisoara “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Figure: CD68 immunoexpression with cytoplasmic pattern in Kupffer cells, CD 68 immunostaining, X400. The Kupffer cells were first described in the microglia, the liver- Kupffer cell, the 1876 by Karl Wilhelm von Kupffer, who called them lung- alveolar macrophages, the Langerhans cells. The “strenzellen”, star cells or stellate hepatic cells. He mechanisms responsible for generating diverse types considered that the above mentioned cells belong to a of macrophages in human remain unclear. The mecha- perivascular cell group- the pericytes. In 1898, he re- nisms of KC renewal are unclear. Two hypotheses were viewed his initial analysis, and stated that these cells are proposed: the classic one, in which the Kupffer cells an essential component of the endothelium, capable are not capable of cell renewal and they come from of phagocytosis of foreign substances. In 1898, Tadeus monocytes derived from the bone marrow. The second Browiecz described them as belonging to the macro- hypothesis argues that Kupffer cells are a population phage family. with regenerative capacity that can proliferate as mature As origin, differentiation and proliferation, cells or that originate from local intrahepatic progen- Kupffer cells appear for the first time, during the itors. The life of macrophages was described as 3.8 development, at the Yolk sac. Then, they migrate into days. In liver transplant patients, donor Kupffer cells the fetal liver through the umbilical veins and left veins persisted for up to one year.
    [Show full text]
  • The Pathology of Hepatic Cirrhosis: Analyzing Cytokine Signaling, Hepatocytes, and Collagen
    Eastern Washington University EWU Digital Commons 2020 Symposium Posters 2020 Symposium Spring 2020 The pathology of hepatic cirrhosis: analyzing cytokine signaling, hepatocytes, and collagen. Nicole Hamada Eastern Washington University, [email protected] Follow this and additional works at: https://dc.ewu.edu/srcw_2020_posters Part of the Pathological Conditions, Signs and Symptoms Commons Recommended Citation Hamada, Nicole, "The pathology of hepatic cirrhosis: analyzing cytokine signaling, hepatocytes, and collagen." (2020). 2020 Symposium Posters. 46. https://dc.ewu.edu/srcw_2020_posters/46 This Poster is brought to you for free and open access by the 2020 Symposium at EWU Digital Commons. It has been accepted for inclusion in 2020 Symposium Posters by an authorized administrator of EWU Digital Commons. For more information, please contact [email protected]. The pathology of hepatic cirrhosis: analyzing cytokine signaling, hepatocytes, and collagen. Nicole Hamada and Dr. Judd Case Department of Biology, Eastern Washington University, Cheney WA Abstract Introduction Cont. Results Cont. Discussion Chronic liver disease and cirrhosis takes the life of approximately Type I and III collagen are affected by cirrhosis. Type III of collagen is Chronic cirrhosis takes the lives of approximately 41,000 individuals 41,000 individuals each year in the United States (CDC, 2019). The The hepatocytes become small, dehydrated cells that begin to lose replaced by collagen type I. This is a result of cytokine signaling from each year in the United States. This disease is a result of either liver’s many responsibilities are filtering the blood, detoxifying their functionality. The hepatocytes that aren’t included in the the hepatic cellulite cell which starts fibrogenesis.
    [Show full text]
  • Histology of the Liver, and the Biliary System
    Histology of the liver, and the biliary system Dr. Zsuzsanna Tóth Semmelweis University Department of Anatomy, Histology and Embryology http://www.mgtowforums.com/forums/lads-night-inn/3969-give-your-liver-art.html What does liver do? More than 500 vital functions have been identified with the liver. Organization of lipid metabolism Storage of vitamins Conversion excess glucose into production of cholesterol. glycogen and vica versa in need. (A, B12, folic acid). Gluconeogenezis. Regulation of blood levels of amino acids. Progressing hemoglobin for use of its iron, storing iron and cupper. Production of plazma proteins (albumin, fibrinogen, blood coagulation factors, transferrin). Production of bile which helps carry away waste (ie. bilirubin) and break down fats in the small Clearing the blood of drugs and other intestine during digestion. poisonous substances. Conversion of poisonous ammonia to urea. Production and conversion of signal Resisting infections by producing molecules and hormones. immune factors and removing (erytropoetin, angiotensinogen, bacteria from the bloodstream. hepcidin, IGF1,2, trijodtyronin). Special circulation of the liver has a basic importance Dual blood supply of the liver Input: • 75% portal vein o poor in oxygen o rich in nutritions and pancreatic hormones ( from the bowels), o rich in hemoglobin metabolites-bilirubin and heme (from the spleen) o the liver is in a situation to be a key metabolic center • 25% hepatic artery o rich in oxigen Output: The liver is the first organ for the absorbed • hepatic veins → inferior vena cava material to reach from the gut. Complex lipids (chylomicrons) reach the liver through the lymph vessels. Glisson’s capsule Glisson’s capsule • The liver is covered by a fibrous capsule called Glisson’s capsule.
    [Show full text]