Chemical Biology Volume 52 (2019 ) Editor Benjamin G Davis UK

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Current Opinion in Chemical Biology Volume 52 ( 2019 ) Editor Benjamin G Davis UK Editorial Enquiries Editorial Board 2019 Contents Current Opinion in Chemical Biology Duilio Arigoni (Switzerland) The subject of chemical biology is divided into Elsevier Jacqueline K. Barton (USA) nine major sections, each of which is reviewed once a year. Each issue contains one or two of the Radarweg 29 Hagan Bayley (UK) sections, and the amount of space devoted to Stephen J. Benkovic (USA) 1043 NX Amsterdam each section is related to its importance. The Netherlands Carolyn Bertozzi (USA) Tel.: +31 (0)20 485 2560 Thomas Cech (USA) e-mail: [email protected] Michelle Chang (USA) February Peng Chen (China) Jason Chin (UK) Omics Benjamin F. Cravatt (USA) Edited by Ileana M. Cristea and Kathryn S. Lilley Current Opinion in Chemical Biology William F. DeGrado (USA) ISSN 1367-5931 Peter B. Dervan (USA) is published bimonthly by Alan R. Fersht (UK) April Elsevier Katharina Gaus (Australia) www.elsevier.com Biocatalysis and Biotransformation Harry B. Gray (USA) Edited by Kylie Vincent and Bettina Nestl Jay Groves (USA) Bioinorganic Chemistry The Aims of the journal can be found at Itaru Hamachi (Japan) Edited by Kyle Lancaster www.elsevier.com/locate/cbi Chuan He (USA) Paul J. Hergenrother (USA) Current Opinion in Chemical Biology Donald Hilvert (Switzerland) June is indexed and/or abstracted by Philipp Holliger (UK) BIOSIS Linda Hsieh-Wilson (USA) Next Generation Therapeutics CAB Abstracts International Barbara Imperiali (USA) Edited by Paul Hergenrother and Yimon Aye CAB Health J. Bryan Jones (Canada) Chemical Abstracts Daniel Kahne (USA) August EMBASE Stephen H.B. Kent (USA) Chaitan Khosla (USA) Medline Chemical Genetics and Epigenetics Also covered in the abstract and citation Thomas Kodadek (USA) Edited by Xiaoguang Lei and Xiang David Li Jean-Marie Lehn (France) database SciVerse Scopus® Molecular Imaging David Liu (USA) Full text available on SciVerse ScienceDirect® Edited by Philipp Kukura and Sua Myong Tetsuo Nagano (Japan) Dario Neri (Switzerland) Tom O'Halloran (USA) October Emily Parker (New Zealand) Richard Payne (Australia) Synthetic Biology Lawrence Que (USA) Edited by Hirohide Saito and Yohei Yokobayashi Julius Rebek (USA) Synthetic Biomolecules Janos Retey (Germany) Edited by Johan Winne and Annemieke Madder Alanna Schepartz (USA) Stuart L. Schreiber (USA) Peter G. Schultz (USA) December Peter Seeberger (Germany) Joan Selverstone Valentine (USA) Mechanistic Biology Scott K. Silverman (USA) Edited by David Vocadlo and Hermen Overkleeft W. Clark Still (USA) Chemical Biophysics Hiroaki Suga (Japan) Edited by Jie Yan and Terence Strick Suzanne Walker (USA) Stephen G. Withers (Canada) Chi-Huey Wong (USA) Dan Yang (China) Amsterdam – Boston – London – New York – Oxford – Paris – Philadelphia – San Diego – St. Louis.

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The-Chemical-Biologist.Pdf
Chunxiao Song LUDWIG WORKING FROM HOME “Basically, everything around us can be represented in this very simple and elegant way. It seemed like the whole world could be written in simple formulas.” 38 The chemical biologist IN 2008, CHUNXIAO SONG WAS JUST A dozen years on, that lost feeling is a beginning his graduate studies in chemistry pleasantly dim memory for Song, who is at the University of Chicago. It was not going now an assistant member of the Oxford well. A foreign student from China, Song Branch of the Ludwig Institute for Cancer had never traveled outside his country, and Research. In 2019, Song, in collaboration the pressure and loneliness were starting to with his Ludwig Oxford colleague Benjamin get to him. “Graduate studies, especially for Schuster-Boeckler, published a study in the foreigners, can be tough,” Song says. journal Nature Biotechnology that detailed a greatly improved method for mapping a He was professionally adrift as well. During key chemical—or “epigenetic”—modification college at Peking University, Song had made to DNA known as methylation. majored in organic chemistry. Now, eager Epigenetic modifications play a critical to harness chemistry to probe the natural role in controlling gene expression, and world, he had switched his focus to chemical aberrant methylation across the genome biology. He was adept at designing reactions has long been known to be a hallmark of to create synthetic molecules without cancer. In 2020, Song and his colleagues concern for their immediate utility. But in launched a company named Base Genomics the biological world, chemistry is only useful to commercialize their new technology to the extent that it explains or enables and apply it to minimally invasive cancer discovery.
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