Camille Dreyfus Teacher-Scholar Awards Program
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Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H. -
The-Chemical-Biologist.Pdf
Chunxiao Song LUDWIG WORKING FROM HOME “Basically, everything around us can be represented in this very simple and elegant way. It seemed like the whole world could be written in simple formulas.” 38 The chemical biologist IN 2008, CHUNXIAO SONG WAS JUST A dozen years on, that lost feeling is a beginning his graduate studies in chemistry pleasantly dim memory for Song, who is at the University of Chicago. It was not going now an assistant member of the Oxford well. A foreign student from China, Song Branch of the Ludwig Institute for Cancer had never traveled outside his country, and Research. In 2019, Song, in collaboration the pressure and loneliness were starting to with his Ludwig Oxford colleague Benjamin get to him. “Graduate studies, especially for Schuster-Boeckler, published a study in the foreigners, can be tough,” Song says. journal Nature Biotechnology that detailed a greatly improved method for mapping a He was professionally adrift as well. During key chemical—or “epigenetic”—modification college at Peking University, Song had made to DNA known as methylation. majored in organic chemistry. Now, eager Epigenetic modifications play a critical to harness chemistry to probe the natural role in controlling gene expression, and world, he had switched his focus to chemical aberrant methylation across the genome biology. He was adept at designing reactions has long been known to be a hallmark of to create synthetic molecules without cancer. In 2020, Song and his colleagues concern for their immediate utility. But in launched a company named Base Genomics the biological world, chemistry is only useful to commercialize their new technology to the extent that it explains or enables and apply it to minimally invasive cancer discovery. -
Hemistry N E W S L E T T E R
University of Michigan Chemistry N E W S L E T T E R Letter from the Chair I am pleased to send greetings and to fullerene, was a very engaging keynote Contents highlight the activities of the Chemistry speaker for this event. Before his talk, the Department this past year. The Depart- Department was awarded a 2006 Citation Letter from the Chair ........................ 1 ment is continuing to make enormous for Chemical Breakthroughs from the Di- New Faculty ..................................... 3 strides towards accomplishing its goal of vision of the History of Chemistry of the becoming one of the top Chemistry De- American Chemical Society in recognition Faculty News.................................... 4 partments in the nation. The most recent of work by Moses Gomberg. Additionally, I 150th Birthday ...................................4 US News and World Report ranking of have enjoyed meeting departmental alumni Graduate Program News Chemistry Departments listed Michigan and alumnae as well as prospective faculty as 16th in the nation; the analytical cluster candidates at the University of Michigan Graduate Awards .......................... 7 was ranked 9th, biochemistry 13th, organic reception that is held at every American Graduate Degrees........................ 10 th th 13 , and inorganic 15 . These are the Chemical Society National meeting. Please GS Council News .........................12 highest rankings for these clusters in many plan on attending this reception at the next years. We anticipate that our standing in ACS meeting. Undergraduate Program News the community will continue to rise, in REU Program ...............................12 Over the past year the department has view of the tremendous success that we recruited Dr. Anne McNeil, an outstand- Undergraduate Awards ............... -
Julia A. Kalow
JULIA A. KALOW Department of Chemistry Northwestern University Technological Institute, M290 (847) 467-4972 2145 Sheridan Rd [email protected] Evanston, IL 60208 http://sites.northwestern.edu/kalowlab/ RESEARCH EXPERIENCE Assistant Professor, Northwestern University, Department of Chemistry 2016–present Ruth L. Kirschstein Postdoctoral Fellow, Massachusetts Institute of Technology 2013–2016 Advisor: Professor Timothy M. Swager • Developed an efficient synthesis of telechelic P3HT and a versatile strategy to prepare miktoarm branched polymers based on ring-opening metathesis polymerization. • Studied the self-assembly of novel architectures of conjugated polymers in solution and in bulk. • Collaborated with a team of researchers studying tunable complex emulsions and applied these emulsions to enzyme sensing. • Mentored a visiting undergraduate student from Tianjin University (Xinping He). Graduate Research Assistant, Princeton University, Department of Chemistry 2008–2013 Advisor: Professor Abigail G. Doyle Thesis title: Catalytic strategies for asymmetric nucleophilic fluorination using a latent HF source: Development and mechanistic investigations • Initiated a program in asymmetric catalytic nucleophilic fluorination in the Doyle lab and introduced the use of benzoyl fluoride as a latent HF source for C–F bond formation. • Discovered key mechanistic insights into cooperative catalysis in the fluorination reactions that have led to additional projects, including selective radiofluorination. • Mentored an undergraduate chemistry major (Dana Schmitt, class of 2012). Intern, Merck Research Laboratories, Medicinal Chemistry, Boston, MA Summer 2007 • Investigated metal-catalyzed trifluoromethylation methods (with Dr. Jed Hubbs). Undergraduate Researcher, Columbia University, Department of Chemistry 2005–2008 Advisor: Professor James L. Leighton • Participated in studies toward the synthesis of isocyclocitrinol A (with Dr. Arash Soheili). • Developed an enantioselective imino-Nazarov rearrangement (with Dr. -
Dioxygen Activation in Soluble Methane Monooxygenase
Dioxygen Activation in Soluble Methane Monooxygenase The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Tinberg, Christine E., and Stephen J. Lippard. “Dioxygen Activation in Soluble Methane Monooxygenase.” Accounts of Chemical Research 44.4 (2011): 280–288. As Published http://dx.doi.org/10.1021/ar1001473 Publisher American Chemical Society Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/69856 Terms of Use Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. Dioxygen Activation in Soluble Methane Monooxygenase† Christine E. Tinberg and Stephen J. Lippard* Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139 RECEIVED DATE (to be automatically inserted after your manuscript is accepted if required according to the journal that you are submitting your paper to) * To whom correspondence should be addressed. E-mail: [email protected]. Telephone: (617) 253-1892. Fax: (617) 258-8150. †Work from our laboratory discussed in this Account was funded by grant GM032134 from the National Institute of General Medical Sciences. 1 CONSPECTUS The controlled oxidation of methane to methanol is a chemical transformation of great industrial importance that is underutilized because of inefficient and costly synthetic procedures. Methane monooxygenase enzymes (MMOs) from methanotrophic bacteria achieve this chemistry efficiently under ambient conditions. In this Account we discuss the first step in the oxidation of methane at the carboxylate-bridged diiron active site of the soluble MMO (sMMO), namely, the reductive activation of atmospheric O2. -
Here Science-Based Cost- Effective Pathways Forward?
Sponsors Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan PIRE-ECCI Program, UC Santa Barbara, USA Max-Planck-Gesellschaft, Germany National Science Council, Taiwan Organizing committee Dr. Kuei-Hsien Chen (IAMS, Academia Sinica, Taiwan) Dr. Susannah Scott (University of California - Santa Barbara, USA) Dr. Alec Wodtke (University of Göttingen & Max-Planck-Gesellschaft, Germany) Table of Contents General Information .............................................................................................. 1 Program for Sustainable Energy Workshop ....................................................... 3 I01 Dr. Alec M. Wodtke Beam-surface Scattering as a Probe of Chemical Reaction Dynamics at Interfaces ........................................................................................................... 7 I02 Dr. Kopin Liu Imaging the steric effects in polyatomic reactions ............................................. 9 I03 Dr. Chi-Kung Ni Energy Transfer of Highly Vibrationally Excited Molecules and Supercollisions ................................................................................................. 11 I04 Dr. Eckart Hasselbrink Energy Conversion from Catalytic Reactions to Hot Electrons in Thin Metal Heterostructures ............................................................................................... 13 I05 Dr. Jim Jr-Min Lin ClOOCl and Ozone Hole — A Catalytic Cycle that We Don’t Like ............... 15 I06 Dr. Trevor W. Hayton Nitric Oxide Reduction Mediated by a Nickel Complex -
Call for Papers | 2022 MRS Spring Meeting
Symposium CH01: Frontiers of In Situ Materials Characterization—From New Instrumentation and Method to Imaging Aided Materials Design Advancement in synchrotron X-ray techniques, microscopy and spectroscopy has extended the characterization capability to study the structure, phonon, spin, and electromagnetic field of materials with improved temporal and spatial resolution. This symposium will cover recent advances of in situ imaging techniques and highlight progress in materials design, synthesis, and engineering in catalysts and devices aided by insights gained from the state-of-the-art real-time materials characterization. This program will bring together works with an emphasis on developing and applying new methods in X-ray or electron diffraction, scanning probe microscopy, and other techniques to in situ studies of the dynamics in materials, such as the structural and chemical evolution of energy materials and catalysts, and the electronic structure of semiconductor and functional oxides. Additionally, this symposium will focus on works in designing, synthesizing new materials and optimizing materials properties by utilizing the insights on mechanisms of materials processes at different length or time scales revealed by in situ techniques. Emerging big data analysis approaches and method development presenting opportunities to aid materials design are welcomed. Discussion on experimental strategies, data analysis, and conceptual works showcasing how new in situ tools can probe exotic and critical processes in materials, such as charge and heat transfer, bonding, transport of molecule and ions, are encouraged. The symposium will identify new directions of in situ research, facilitate the application of new techniques to in situ liquid and gas phase microscopy and spectroscopy, and bridge mechanistic study with practical synthesis and engineering for materials with a broad range of applications. -
Marye Anne Fox Papers
http://oac.cdlib.org/findaid/ark:/13030/c8fn19bp No online items Marye Anne Fox Papers Finding aid prepared by Special Collections & Archives, UC San Diego Special Collections & Archives, UC San Diego 9500 Gilman Drive La Jolla, California, 92093-0175 858-534-2533 [email protected] Copyright 2014 Marye Anne Fox Papers MSS 0764 1 Descriptive Summary Title: Marye Anne Fox Papers Identifier/Call Number: MSS 0764 Contributing Institution: Special Collections & Archives, UC San Diego 9500 Gilman Drive La Jolla, California, 92093-0175 Languages: English Physical Description: 2.0 Linear feet (5 archives boxes) Date (inclusive): 1969 - 2011 Abstract: The papers of physical organic chemist Marye Anne Fox, documenting her career as a researcher and professor. The collection dates from 1969-2011 and includes reprints, teaching files, subject files, notebooks, and grant proposals. Creator: Fox, Marye Anne, 1947- Scope and Content of Collection The papers of Marye Anne Fox, seventh chancellor of UC San Diego and National Medal of Science laureate, document her career as a researcher and professor of physical organic chemistry. The collection dates from 1969-2011 and is arranged in five series: 1) REPRINTS, 2) TEACHING FILES, 3) SUBJECT FILES, 4) NOTEBOOKS and 5) GRANT PROPOSALS. SERIES 1: REPRINTS The REPRINTS series contains most of Fox's published scientific articles from 1970-1999, arranged chronologically, including collaborative works with other researchers. Her research in the fields of organic photochemistry and electrochemistry has applications in solar energy, semiconductors, functional polymers, and environmental chemistry. SERIES 2: TEACHING FILES The TEACHING FILES series (1969-1993) includes notes, syllabi, problem sets, exam questions and departmental memoranda used by Fox while teaching advanced organic chemistry and photochemistry at the University of Texas, Austin. -
Academic Career Research Interests Honors and Awards
Prof. Dr. Christian P.R. Hackenberger born 04.02.1976 in Osnabrück Humboldt Universität zu Berlin Leibniz‐Forschungsinstitut für Molekulare Pharmakologie (FMP) Homepage: www.fmp‐berlin.info/hackenbe/ Academic career 1996 – 1998 Undergraduate studies and prediploma in Chemistry Albert‐Ludwigs‐Universität Freiburg 1998 – 1999 Graduate studies and M.Sc. with Prof. Samuel H. Gellman Univ. of Wisconsin/Madison, USA 2000 – 2003 Ph.D. research with Prof. Carsten Bolm (summa cum laude) RWTH‐Aachen 2003 – 2005 Postdoctoral work with Prof. Barbara Imperiali Massachusetts Institute of Technology, USA 2004 Research stay with Prof. Sheena E. Radford University of Leeds, UK 2005 – 2006 Junior group leader as Liebig‐Scholar (FCI) Freie Universität Berlin 2006 – 2011 Emmy‐Noether‐Group leader (DFG) Freie Universität Berlin 2011 Habilitation and venia legendi in Organic Chemistry Freie Universität Berlin 2011 – 2012 Associate Professor (W2) for Bioorganic Chemistry Freie Universität Berlin 2012 – Leibniz‐Humboldt‐Professor (W3) for Chemical Biology Humboldt Universität zu Berlin and FMP Research interests ‐ Development of ligation and modification strategies for the synthesis of functional proteins ‐ Labeling strategies for antibody‐ and nanobody‐conjugates, generation of antibody‐drug‐conjugates (ADCs) ‐ Synthesis and proteomic analysis of labile phosphorylated peptides (pLys and pCys) ‐ Intracellular delivery and targeting of functional proteins ‐ Functional investigation of the Alzheimer‐relevant Tau protein ‐ Engineering of protein‐based multivalent scaffolds, metabolic oligosaccharide engineering Honors and Awards 2018 Leonidas Zervas Award of the European Peptide Society 2018 Leibniz Gründerpreis for the foundation of Tubulis Technologies 2016 Fellow of the Royal Society of Chemistry 2014 “The best 40 under 40 in Germany” (Welt am Sonntag) 2013 Harlan L. -
Caged Phosphopeptides and Phosphoproteins: Agents in Unraveling Complex Biological Pathways
Caged Phosphopeptides and Phosphoproteins: Agents in Unraveling Complex Biological Pathways by Deborah Maria Rothman S. B., Biochemistry, University of Chicago, 2000 A. B., Biology, University of Chicago, 2000 Submitted to the Department of Chemistry in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy at the Massachusetts Institute of Technology June 2005 MASSACi.USE_.]S iNSTITTE OF TECHNOLOGY © 2005 Massachusetts Institute of Technology JUN 2 1 2005 All rights reserved LIBRARIES Signature of Author: ( I I 1., , ,, - Department of Chemistry May 9, 2005 Certified by: Barbara Imperiali Class of 1922 Professor of Chemistry and Professor of Biology Thesis Supervisor Accepted by: Robert W. Field Haslam and Dewey Professor of Chemistry Chairman, Departmental Committee on Graduate Students AtmCHlvtS This doctoral thesis has been examined by a committee of the Department of Chemistry as follows: Timothy F. Jamison Chairman Professor of Chemistry 6) Barbara ImDerialiI Thesis Supervisor Class of 1922 Professor of Chemistry and Professor of Biology Douglas A. Lauffenburger oafEr fi s o ei/- g/ a Bl Whitaker Professor of Biological Engineering, Pofessor of themica/ngineering and Biology 2 Caged Phosphopeptides and Phosphoproteins: Agents in Unraveling Complex Biological Pathways by Deborah Maria Rothman Submitted to the Department of Chemistry on May 9, 2005 in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy ABSTRACT Within cellular signaling, protein phosphorylation is the post-translational modification most frequently used to regulate protein activity. Protein kinases and phosphoprotein phosphatases generate and terminate these phosphoryl signals, respectively. Chemical approaches for studying protein phosphorylation and the roles of phosphoproteins include photolabile caged analogs of bioactive species. -
The Future of Life
Second Annual John H. Chafee Memorial Lecture on Science and the Environment The Future of Life Dr. Edward O. Wilson Pellegrino University Research Professor, Harvard University December 6, 2001 THE NATIONAL COUNCIL FOR SCIENCE AND THE ENVIRONMENT (NCSE) has been working since 1990 to improve the scientific basis of environmental decisionmaking and has earned an impressive reputa- tion for objectivity, responsibility, and achievement. The Council envisions a society where environmental decisions are based on an accurate understanding of the underlying science, its meaning, and its limitations. In such a society, citizens and decisionmakers receive accurate, understandable, and integrated science-based information. They understand the risks, uncertainties, and potential consequences of their action or inaction. Supported by over 500 academic, scientific, environmental, and business organizations, and federal, state, and local government, NCSE works closely with the many communities creating and using environmental knowledge to make and shape environmental decisions. The Council operates a range of innovative activities in the areas of: Promoting Science for the Environment The Council played an instrumental role in stimulating the National Science Foundation initiative to triple its annual budget for environmental research, education, and scientific assessment. The Council presents expert testimony to Congressional committees, consults regularly with key decisionmakers in government, and works to promote funding for environmental programs at numerous federal agencies. Enhancing Programs at Institutions of Higher Learning NCSE brings members of the academic community together to improve their environmental programs and increase their value to society through the University Affiliate Program, the Council of Environ- mental Deans and Directors, and the Minority Programs Office. -
The Life of a Professor Email Print
Log In ACS ACS Publications C&EN CAS About Subscribe Advertise Contact Join ACS Serving The Chemical, Life Sciences & Laboratory Worlds Search Adv anced Search Home Magazine News Departments Collections Blogs Multimedia Jobs Home > Volume 92 Issue 11 > The Lif e Of A Prof essor Volume 92 Issue 11 | pp. 14-18 Issue Date: March 17, 2014 0 0 MOST POPULAR COVER STORIES: TRAILBLAZER AND MENTOR Viewed Commented Shared The Life Of A Professor Email Print Spider Silk Poised For Commercial Department: Science & Technology, ACS News | Collection: Life Sciences Entry News Channels: JACS In C&EN Keywords: Priestley Medal, Stephen Lippard Controversy Clouds E-Cigarettes Reports Make Progress In Transforming C–H Bonds Into Druglike Motifs I am honored to receive the 2014 Priestley Medal. The award is a tribute to the talented Cover Stories students, both graduate and undergraduate, as well as postdoctoral associates who Global Top 50 have trained with me over nearly 50 years. I am proud of these individuals, for their Trailblazer And Mentor Milk Proteins Protect Fabrics From courage in agreeing to venture onto new snowfields to place the first footprints, for their The Life Of A Professor Fire relentless pursuit of the truth, and for their creative ideas and clever experiments that *Most Viewed in the last 7 days brought insight where previously there was often confusion. Of equal importance are the many collaborators who have greatly facilitated our ability to Advertisement make progress in areas beyond our knowledge base. If “professor” stands for “professional student,” these individuals have been my teachers. I thank them, the ACS Board of Directors who award this medal, and those who entered and supported my nomination.