Chemical Biology Volume 48 (2019 ) Editor Benjamin G Davis UK

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Current Opinion in Chemical Biology Volume 48 ( 2019 ) Editor Benjamin G Davis UK Editorial Enquiries Editorial Board 2019 Contents Current Opinion in Chemical Biology Duilio Arigoni (Switzerland) The subject of chemical biology is divided into Elsevier Jacqueline K. Barton (USA) nine major sections, each of which is reviewed once a year. Each issue contains one or two of the Radarweg 29 Hagan Bayley (UK) sections, and the amount of space devoted to Stephen J. Benkovic (USA) 1043 NX Amsterdam each section is related to its importance. The Netherlands Carolyn Bertozzi (USA) Tel.: +31 (0)20 485 2560 Thomas Cech (USA) e-mail: [email protected] Michelle Chang (USA) February Peng Chen (China) Jason Chin (UK) Omics Benjamin F. Cravatt (USA) Edited by Ileana M. Cristea and Kathryn S. Lilley Current Opinion in Chemical Biology William F. DeGrado (USA) ISSN 1367-5931 Peter B. Dervan (USA) is published bimonthly by Alan R. Fersht (UK) April Elsevier Katharina Gaus (Australia) www.elsevier.com Biocatalysis and Biotransformation Harry B. Gray (USA) Edited by Kylie Vincent and Bettina Nestl Jay Groves (USA) The Aims of the journal can be found at Bioinorganic Chemistry Itaru Hamachi (Japan) Edited by Kyle Lancaster www.elsevier.com/locate/cbi Chuan He (USA) Paul J. Hergenrother (USA) Current Opinion in Chemical Biology Donald Hilvert (Switzerland) June is indexed and/or abstracted by Philipp Holliger (UK) BIOSIS Linda Hsieh-Wilson (USA) Next Generation Therapeutics Edited by Paul Hergenrother and Yimon Aye CAB Abstracts International Barbara Imperiali (USA) CAB Health J. Bryan Jones (Canada) Daniel Kahne (USA) Chemical Abstracts August EMBASE Stephen H.B. Kent (USA) Medline Chaitan Khosla (USA) Molecular Imaging Also covered in the abstract and citation Thomas Kodadek (USA) Edited by Philipp Kukura and Sua Myong Jean-Marie Lehn (France) database SciVerse Scopus® Chemical Genetics and Epigenetics Stephen J. Lippard (USA) Full text available on SciVerse ScienceDirect® Edited by Xiaoguang Lei and David Xiang Li David Liu (USA) Tetsuo Nagano (Japan) Dario Neri (Switzerland) October Tom O'Halloran (USA) Emily Parker (New Zealand) Synthetic Biology Edited by Hirohide Saito and Yohei Yokobayashi Richard Payne (Australia) Lawrence Que (USA) Synthetic Biomolecules Julius Rebek (USA) Edited by Annemieke Madder and Johan Winne Janos Retey (Germany) Alanna Schepartz (USA) December Stuart L. Schreiber (USA) Peter G. Schultz (USA) Mechanistic Biology Peter Seeberger (Germany) Edited by David Vocadlo and Hermen Overkleeft Joan Selverstone Valentine (USA) Energy Scott K. Silverman (USA) Edited by Fraser Armstrong W. Clark Still (USA) Chemical Biophysics Hiroaki Suga (Japan) Edited By by Jie Yan and Terence Strick Suzanne Walker (USA) Stephen G. Withers (Canada) Chi-Huey Wong (USA) Dan Yang (USA) Amsterdam – Boston – London – New York – Oxford – Paris – Philadelphia – San Diego – St. Louis.

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Chunxiao Song LUDWIG WORKING FROM HOME “Basically, everything around us can be represented in this very simple and elegant way. It seemed like the whole world could be written in simple formulas.” 38 The chemical biologist IN 2008, CHUNXIAO SONG WAS JUST A dozen years on, that lost feeling is a beginning his graduate studies in chemistry pleasantly dim memory for Song, who is at the University of Chicago. It was not going now an assistant member of the Oxford well. A foreign student from China, Song Branch of the Ludwig Institute for Cancer had never traveled outside his country, and Research. In 2019, Song, in collaboration the pressure and loneliness were starting to with his Ludwig Oxford colleague Benjamin get to him. “Graduate studies, especially for Schuster-Boeckler, published a study in the foreigners, can be tough,” Song says. journal Nature Biotechnology that detailed a greatly improved method for mapping a He was professionally adrift as well. During key chemical—or “epigenetic”—modification college at Peking University, Song had made to DNA known as methylation. majored in organic chemistry. Now, eager Epigenetic modifications play a critical to harness chemistry to probe the natural role in controlling gene expression, and world, he had switched his focus to chemical aberrant methylation across the genome biology. He was adept at designing reactions has long been known to be a hallmark of to create synthetic molecules without cancer. In 2020, Song and his colleagues concern for their immediate utility. But in launched a company named Base Genomics the biological world, chemistry is only useful to commercialize their new technology to the extent that it explains or enables and apply it to minimally invasive cancer discovery.
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