A Tipping Point in Cancer Research

A Tipping Point in Cancer Research Annual Report 2011 In this new era of accelerated progress, Their innovative contributions have it is more important than ever that we support been widely recognized: creative young scientists who can harness the • 2 Damon Runyon scientists were included in A Tipping Point in Cancer Research momentum of the past decade to transform the Science magazine’s Insights of the Decade, way we prevent, detect, and treat cancer. The Celebrating Extraordinary Progress which listed “10 insights that have changed science Damon Runyon Cancer Research Foundation is since the dawn of the new millennium.” Scientists, research organizations and the National Cancer Institute all agree: playing a central role by funding groundbreaking we are at a tipping point in cancer research. The convergence of knowledge from across the spectrum basic and clinical cancer research. In the past year, • 2 Damon Runyon alumni were elected to the of cutting-edge science combined with powerful new technologies has created a deeper understanding our brilliant young scientists: National Academy of Sciences (the science “Hall of Fame”), bringing Damon Runyon’s total to 61. of cancers and advanced our ability to detect and treat these diseases earlier and more effectively. • led studies resulting in FDA approval of two new drugs for advanced melanoma: Yervoy, an immu- • William R. Sellers, MD, Board Member and notherapy, and Zelboraf, a targeted therapy former Clinical Investigator, was appointed by President Obama to the National Cancer • reported the success of a novel immunotherapy Advisory Board. for pancreatic cancer • Elaine V. Fuchs, PhD, Board Member and • completed the first genome sequencing of former Fellow, received the prestigious Albany multiple myeloma and medulloblastoma Medical Center Prize. • established the link between changes in cell • Current Innovator Muneesh Tewari, MD, PhD, metabolism and brain tumor development was awarded a Presidential Early Career Award • developed a new understanding of how inflam- for Scientists and Engineers. mation leads to drug resistance in cancer cells

1 The Damon Runyon Cancer Research Foundation 2011 Annual Report 2 We also launched a new initiative, Damon Runyon formed to address the critical the Cancer Breakthrough Fund, shortage of high-quality clinical investigators. A Tipping Point in Cancer Research to invest in 100 of the most brilliant young cancer This new model for collaboration will increase researchers. We believe that these innovative minds, resources to support young clinical researchers, A Time to Act with their audacity and unfettered creativity, are rebuilding the ranks of those who have the the key to building on recent gains and translating potential to make cutting-edge breakthroughs in It is critical that we seize this moment and act on the extraordinary progress discoveries into solutions. cancer treatments, translating science into cures. of the past year and the past decade. That is why the Damon Runyon Cancer Research Our goal is to raise a fund of $50 million over the Its charter members have already pledged $5.1 Foundation is increasing its investment. In the past year, we awarded $10.2 million in new scientific next five years that we will put to work as rapidly million and include: grants and funded 122 scientists at 41 institutions in 17 states. as possible to support 50 Damon Runyon-Rachleff Innovators focused on high-risk, high-reward discovery and 50 Damon Runyon Clinical Inves- tigators committed to bringing new therapies to cancer patients. The inaugural event in January in Menlo Park, California, raised $1.6M in new commitments for this bold new effort. Accelerating Cancer Cures, a part of the Cancer Breakthrough Fund, is an historic collaboration www.damonrunyon.org/accelerate of the biopharmaceutical industry, academia and

of all donations 100% fund cancer research

All administrative and fundraising expenses are paid through Damon Runyon Broadway Tickets and our endowment.

3 The Damon Runyon Cancer Research Foundation 2011 Annual Report 4 Thank You To Our Donors Damon Runyon Board of Directors

Every new discovery that our young scientists make is directly linked to your support, and we are immensely Steven J. Burakoff, MD Mr. Jay W. Ireland grateful for the generosity of all of our donors. Thanks to you, Damon Runyon raised nearly $10 million and Director President and Chief Executive Officer The Tisch Cancer Institute GE Africa received more than $1.6 million in bequests in Fiscal Year 2011. Mount Sinai School of Medicine Nairobi, Kenya New York, New York Mr. Steven A. Kandarian Our Annual Breakfast, honoring William L. Carroll, MD President and Chief Executive Officer Boston business and philanthropic Director MetLife, Inc. leader Norman B. Leventhal, NYU Cancer Institute New York, New York New York, New York raised $1.16 million. Mr. Noah Knauf The Damon Runyon 5K at Mr. Gary E. Erlbaum Principal President Warburg Pincus Yankee Stadium raised $400,000 Alan M. Leventhal, Greentree Properties San Francisco, California in August 2010, drawing a capacity Chair Ardmore, Pennsylvania crowd of 4,000 participants. A Ronald Levy, MD Thomas J. Fahey Jr., MD Chief, Division of Oncology special thanks to Walgreens, Chair Senior Vice President Professor of Medicine Unilever/White Rose, 24 Hour Mr. Alan M. Leventhal Clinical Program Development Stanford University School of Medicine Fitness, New York Daily News, Chair and Chief Executive Officer Director, International Center Stanford, California Beacon Capital Partners, LLC Memorial Sloan-Kettering Cancer Center NBC4, SiriusXM, Poland Spring Boston, Massachusetts New York, New York Mr. David G. Marshall and Utz for their sponsorship. Chair and Chief Executive Officer Vice Chair Mr. Buck French Amerimar Realty Company Development and Marketing Darien, Connecticut Philadelphia, Pennsylvania Mr. David M. Beirne Aspen, Colorado Mr. Dale F. Frey Mr. John H. Myers Retired Chair of the Board Senior Advisor Vice Chair and President Angelo, Gordon & Co. Finance and Treasurer General Electric Investment Corporation New York, New York Mr. Leon G. Cooperman Weston, Connecticut Chair and Chief Executive Officer Richard J. O’Reilly, MD Omega Advisors, Inc. Mr. John A. Fry Chair, Department of Pediatrics New donors, including the Jake New York, New York President Chief, Bone Marrow Transplantation Wetchler Foundation for Innova- Drexel University Service tive Pediatric Cancer Research Vice Chair Philadelphia, Pennsylvania Memorial Sloan-Kettering Cancer Center Board Development New York, New York and the Richard A. Lumsden Mr. Michael L. Gordon Elaine V. Fuchs, PhD Foundation, committed to Chief Operating Officer Rebecca C. Lancefield Professor Mrs. Katharine F. Plum sponsoring individual Damon Angelo, Gordon & Co. Laboratory Head, Mammalian Cell Hobe Sound, Florida New York, New York Biology and Development Runyon scientists. The Rockefeller University Mr. Andrew S. Rachleff Vice Chair New York, New York President and Chief Executive Officer Damon Runyon Broadway Tickets Scientific Programs Wealthfront continues to offer premium seats David M. Livingston, MD Richard B. Gaynor, MD Faculty, Stanford Graduate to the best shows in town like The Deputy Director Vice President School of Business Cancer Research and Clinical Investigation Palo Alto, California Book of Mormon. Thanks once Dana-Farber/Harvard Cancer Center Emil Frei III Professor of Eli Lilly and Company again to the Shubert Organization, Genetics and Medicine Indianapolis, Indiana Mr. Scott Ryles Harvard Medical School Chair and Chief Executive Officer Nederlander Productions, Ms. Margaret A. Gilliam Boston, Massachusetts Home Value Protection, Inc. Jujamcyn Theaters and Disney President San Francisco, California Theatrical Productions for making Vice Chair Gilliam & Company this program possible. Audit & Corporate Governance New York, New York Ms. Karen D. Seitz Managing Director and Secretary Todd R. Golub, MD Fusion Partners Sanford W. Morhouse, Esq. Director, Cancer Program Learn more at New York, New York www.damonrunyon.org/broadway Of Counsel Broad Institute of Harvard and M.I.T. Dewey & LeBoeuf LLP Cambridge, Massachusetts New York, New York William R. Sellers, MD Mr. Scott Greenstein Vice President and Global Head, Oncology President, Entertainment & Sports Novartis Institutes for Sirius XM Satellite Radio, Inc. BioMedical Research New York, New York Cambridge, Massachussets Mr. Steve Hayden Samuel C. Silverstein, MD Vice Chair John C. Dalton Professor Ogilvy & Mather Worldwide Department of Physiology and New York, New York Cellular Biophysics Columbia University Mr. Bill Helman New York, New York Chief Executive Officer and Managing Partner Greylock Partners Cambridge, Massachusetts

5 The Damon Runyon Cancer Research Foundation 2011 Annual Report 6 Damon Runyon Award Programs Damon Runyon Fellowship Award Committee

Damon Runyon Damon Runyon Clinical CHAIR Tyler Jacks, PhD Norbert Perrimon, PhD Daniel E. Gottschling, PhD Investigator, Howard Hughes Investigator, Howard Hughes Fellowship Award Investigator Award Member, Basic Sciences Division Medical Institute Medical Institute Supports the training of the brightest postdoctoral Supports early career physician-scientists conduct- Fred Hutchinson Cancer Research Center Director, David H. Koch Institute for Professor of Genetics Seattle, Washington Integrative Cancer Research Harvard Medical School scientists as they embark upon their research ing patient-oriented research. The goal of this David H. Koch Professor of Biology Boston, Massachusetts careers. This funding enables them to be mentored innovative program is to increase the number of Vice Chair Ludwig Scholar by established investigators in leading research physicians capable of moving seamlessly between Lynn Cooley, PhD Massachusetts Institute of Technology Rama Ranganathan, MD, PhD Professor of Genetics, Cell Biology and Cambridge, Massachusetts Professor, Department of Pharmacology laboratories across the country. the laboratory and the patient’s bedside in search Molecular, Cellular and Develop- Cecil H. and Ida Green Chair in of breakthrough treatments. mental Biology Liqun Luo, PhD Biomedical Science Three-Year Award Department of Genetics Investigator, Howard Hughes Director, Green Center for Basic Scientists: $156,000 Three-Year Award: $450,000 plus up to Yale University School of Medicine Medical Institute Systems Biology New Haven, Connecticut Professor, Department of University of Texas Southwestern Physician-Scientists: $186,000 $100,000 for medical school loan repayment Biological Sciences Medical Center David P. Bartel, PhD Stanford University Dallas, Texas Investigator, Howard Hughes Stanford, California Dale F. Frey Award for Continuation Grant Medical Institute Amita Sehgal, PhD Breakthrough Scientists Supports Damon Runyon Clinical Investigators Professor of Biology Terry Magnuson, PhD Investigator, Howard Hughes who are approaching the end of their original Massachusetts Institute of Technology Sarah Graham Kenan Professor Medical Institute Supports a select few Damon Runyon Fellows who John Herr Muser Professor three-year awards and need extra time and funding Member Chair, Department of Genetics have greatly exceeded the Foundation’s highest Whitehead Institute for Vice Dean for Research, Department of Neuroscience expectations. This additional investment in these to complete a promising avenue of research or Biomedical Research School of Medicine University of Pennsylvania exceptional individuals is to help catapult their initiate/continue a clinical trial. Cambridge, Massachusetts Program Director, Cancer Genetics School of Medicine Lineberg Comprehensive Cancer Center Philadelphia, Pennsylvania research careers and their impact on cancer. Frederick R. Cross, PhD University of North Carolina Two-Year Award: $300,000 Professor Brent R. Stockwell, PhD School of Medicine Laboratory of Yeast Molecular Genetics Associate Professor Two-Year Award: $200,000 Chapel Hill, North Carolina This program is possible through the support of The Rockefeller University Department of Biological Sciences and Department of Chemistry the William K. Bowes, Jr., Foundation, and Connie New York, New York Philippa C. Marrack, FRS, PhD This program was created to honor Dale F. Frey, Columbia University Investigator, Howard Hughes retired Chairman of the Damon Runyon Board and Bob Lurie. Andrew G. Dillin, PhD New York, New York Medical Institute Investigator, Howard Hughes of Directors, in recognition of his sixteen years of Member, Department of Immunology Medical Institute Wilfred A. van der Donk, PhD visionary leadership. National Jewish Medical and Associate Professor and Pioneer Investigator, Howard Hughes Research Center Developmental Chair Medical Institute Denver, Colorado Damon Runyon-Rachleff Molecular and Cell Biology Lab Richard E. Heckert Professor Salk Institute for Biological Studies of Chemistry Innovation Award David J. McConkey, PhD University of Illinois, Urbana-Champaign La Jolla, California Director of Urologic Research Supports the next generation of exceptionally Urbana, Illinois Robert N. Eisenman, PhD Professor, Departments of Urology creative thinkers with high-risk, high-reward ideas Member, Basic Sciences Division and Cancer Biology Terry A. Van Dyke, PhD that have the potential to significantly impact our Fred Hutchinson Cancer Research Center M.D. Anderson Cancer Center Chief, Mouse Cancer Genetics Program Seattle, Washington The University of Texas Center for Cancer Research understanding of and/or approaches to the pre- Houston, Texas Director, Center for Advanced vention, diagnosis or treatment of cancer. Sankar Ghosh, PhD Preclinical Research Michael T. McManus, PhD Silverstein and Hutt Family Professor National Cancer Institute at Frederick Associate Professor of Microbiology and Immunology Frederick, Maryland Three-Year Award: $450,000 Department of Microbiology Chair, Department of Microbiology and Immunology Johannes Walter, PhD and Immunology This program is possible through a founding grant Diabetes Center Professor Columbia University from Andrew and Debra Rachleff, and the support University of California Department of Biological Chemistry New York, New York of the Island Outreach Foundation. San Francisco, California and Molecular Pharmacology R. Kiplin Guy, PhD Harvard Medical School Ramon E. Parsons, MD, PhD Boston, Massachusetts Chairman, Department of Chemical Avon Foundation Professor of Biology and Therapeutics Medicine and Pathology St. Jude Children’s Research Hospital Institute for Cancer Genetics Memphis, Tennessee Assistant Director of Neuro-Oncology Herbert Irving Comprehensive Thomas S. Hays, PhD Cancer Center Professor, Department of Genetics, Columbia University Cell Biology and Development New York, New York University of Minnesota Minneapolis, Minnesota

7 The Damon Runyon Cancer Research Foundation 2011 Annual Report 8 using high-throughput and mechanistic with Rachel D. Green, PhD, The Johns Rebecca S. Mathew, PhD analyses of allelic expression in Candida Hopkins University, Baltimore Howard Hughes Medical Institute Fellow Damon Runyon Fellowship Awards albicans” with Jonathan S. Weissman, “Revealing epigenetic changes that un- PhD, University of California, San Robin E. Stanley, PhD derlie cellular memory” with Danesh Francisco “Structural and biochemical character- Moazed, PhD, Harvard Medical School, California Sarah E. Ewald, PhD* induced ribosomal protein mRNA ization of the autophagy specific class Boston Daniel H. Kim, PhD Dennis and Marsha Dammerman Fellow degradation” with Karsten Weis, PhD, Deniz Simsek, PhD* 3 phosphatidylinositol 3-phosphate “Epigenetic regulation of X-chromo- “Innate immune detection of Toxoplasma University of California, Berkeley Philip O’Bryan Montgomery Jr. Fellow complex” with James H. Hurley, PhD, Joshua J. Sims, PhD* some inactivation by noncoding RNAs” gondii in the host cell cytosol” with John “Understanding the physiological National Institute of Diabetes and Di- “Regulation of mitochondrial apoptosis” with Barbara J. Wold, PhD, California C. Boothroyd, PhD, Stanford University Yumi Kim, PhD* relevance of distinct polyubiquitin gestive and Kidney Diseases, Bethesda with Peter K. Sorger, PhD, Harvard Institute of Technology, Pasadena School of Medicine, Stanford Howard Hughes Medical Institute Fellow chains in the maintenance of genome Medical School, Boston “Identification of the signaling cascades integrity” with David P. Toczyski, PhD, Massachusetts James P. Scott-Browne, PhD* Tom A. Hartl, PhD regulating meiotic chromosome dy- University of California, San Francisco Costas A. Lyssiotis, PhD Scott J. Valastyan, PhD* Fraternal Order of Eagles Fellow Robert Black Fellow namics” with Abby F. Dernburg, PhD, Amgen Fellow Harry Kriegel Fellow “Function and genomic stability of “Serotonergic neuronal control of University of California, Berkeley Nathan D. Thomsen, PhD* “Reversing the Warburg effect in “A novel system for the unbiased discov- 5-hydroxymethylcytosine” with Anjana growth in Drosophila” with Matthew P. Suzanne and Bob Wright Fellow basal-like breast cancer: a unique point ery of genes that regulate breast cancer Maurizio Righini, PhD* Rao, PhD, La Jolla Institute for Allergy Scott, PhD, Stanford University School “Molecular and cellular mechanism of for therapeutic intervention” with Lewis metastasis” with Joan S. Brugge, PhD, Merck Fellow and Immunology, La Jolla of Medicine, Stanford caspase activation by small molecule C. Cantley, PhD, Beth Israel Deaconess Harvard Medical School, Boston “Single molecule translation control” proenzyme activators” with James A. Medical Center, Boston Ilan Wapinski, PhD Gabriel C. Lander, PhD Liana F. Lareau, PhD with Carlos Bustamante, PhD, University Wells, PhD, University of California, Howard Hughes Medical Institute Fellow Merck Fellow Howard Hughes Medical Institute Fellow of California, Berkeley San Francisco Xu Tan, PhD “Structural roles of enzymes and “Global analysis of the role of 5’ “Unraveling the costs and benefits of Lara C. Skwarek, PhD “Discovery of new potent short hairpin substrates in the construction of a untranslated regions in the regulation Hyun Youk, PhD* gene expression on cellular growth” Robert Black Fellow RNAs targeting pathogenic viruses” microtubule platform that catalyzes of translation” with Patrick O. Brown, Howard Hughes Medical Institute Fellow with Roy Kishony, PhD, Harvard Medical “In vivo identification of novel with Stephen J. Elledge, PhD, Brigham APC-directed ubiquitination of spindle MD, PhD, Stanford University School of “Synthetic development: Elucidating School, Boston regulators of epithelial-mesenchymal and Women’s Hospital, Boston checkpoint proteins” with Eva Nogales, Medicine, Stanford principles for genetically encoding transition” with David Bilder, PhD, Dong Yan, PhD PhD, Lawrence Berkeley National Labo- simple multicellular architectures using Sujun Hua, PhD Wan-Jin Lu, PhD* University of California, Berkeley Howard Hughes Medical Institute Fellow ratory, Berkeley Saccharomyces cerevisiae as a model “Genomic analysis of core transcrip- Merck Fellow “Building a kinase and phosphatase system” with Wendell A. Lim, PhD, Uni- tional regulatory networks in normal “The role of injury-inducible epithelial/ Adam de la Zerda, PhD* network using phosphorylation signa- Sharsti L. Sandall, PhD versity of California, San Francisco and malignant neural stem cells” with stromal feedback signaling pathways in “Imaging cancer glycomes with tures” with Norbert Perrimon, PhD, “Mechanisms regulating maintenance of Ronald A. DePinho, MD, Dana-Farber bladder cancer” with Philip A. Beachy, functionalized carbon nanotubes” with Harvard Medical School, Boston stem cells and the niche in Drosophila” Jesse Zalatan, PhD Cancer Institute, Boston PhD, Stanford University School of Carolyn R. Bertozzi, PhD, University of with D. Leanne Jones, PhD, Salk Institute California, Berkeley “Elucidating the kinetic mechanism by Alexandra Zidovska, PhD Medicine, Stanford Jason M. Crawford, PhD for Biological Studies, La Jolla which a scaffold protein regulates MAPK “Cell division under confinement: “Systematic approaches to discovering Benjamin R. Myers, PhD Orkun Akin, PhD signaling” with Wendell A. Lim, PhD, exploring mechanisms for cell division Hua Lu, PhD* bioactive bacterial metabolites” with “Analyzing the mechanism of Hedgehog Howard Hughes Medical Institute Fellow University of California, San Francisco and volume regulation” with Timothy The Jake Wetchler Foundation for Jon Clardy, PhD, Harvard Medical signaling regulation by the Patched “Live imaging of neuronal targeting J. Mitchison, PhD, Harvard Medical Pediatric Innovation Fellow COLORADO School, Boston protein” with Philip A. Beachy, PhD, in the Drosophila visual system with School, Boston “Homogeneous antibody-drug con- Jianfu (Jeff ) Chen, PhD Stanford University School of Medicine, 2-photon microscopy” with S. Lawrence jugates containing unnatural amino Howard Hughes Medical Institute Fellow Harrison W. Gabel, PhD Stanford Zipursky, PhD, University of California, Niels Bradshaw, PhD acid for targeted AML therapy” with Los Angeles “Epigenetic and cellular control of lung “Dissecting the mechanism and function “Regulation of the SpoIIE phosphatase Peter G. Schultz, PhD, The Scripps Jason A. Reuter, PhD development” with Lee A. Niswander, of Arc regulation by the Angelman and activation of a cell-specific transcrip- Research Institute, La Jolla “Characterizing non-coding RNA in- Christopher J. Hale, PhD PhD, University of Colorado Denver, Syndrome-associated ubiquitin ligase tion factor” with Richard M. Losick, PhD, teractions with dominant regulators of Howard Hughes Medical Institute Fellow Aurora Ube3a” with Michael E. Greenberg, Harvard University, Cambridge Raymond E. Moellering, PhD* neuronal differentiation” with Michael “Understanding how a histone meth- PhD, Harvard Medical School, Boston Howard Hughes Medical Institute Fellow P. Snyder, PhD, Stanford University yltransferase links DNA replication, CONNECTICUT William J. Greenleaf, PhD “Characterization of novel pathogenic Simon Jenni, PhD School of Medicine, Stanford repair and transcription” with Steven E. Kristina M. Herbert, PhD “Fluorogenic single-molecule fluores- pathways in cancer: do tumor cells use Jacobsen, PhD, University of California, Howard Hughes Medical Institute Fellow Howard Hughes Medical Institute Fellow cence enzymology” with X. Sunney Xie, quorum-sensing molecules to support Volker Schweikhard, PhD Los Angeles “Regulation and mechanism of pri-miRNA “Structural and functional studies of ki- PhD, Harvard University, Cambridge malignancy?” with Benjamin F. Cravatt, “A single-molecule study of factors processing by Drosha and DGCR8” with netochores” with Stephen C. Harrison, David G. Hendrickson, PhD PhD, The Scripps Research Institute, TFIIS and TFIIF during transcriptional Christopher S. Campbell, PhD Joan A. Steitz, PhD, Yale University, PhD, Harvard Medical School, Boston Robert Black Fellow La Jolla elongation by RNA polymerase II” with “Control of the chromosomal passenger New Haven Kristin A. Krukenberg, PhD “A guiding role for lincRNAs in the Steven M. Block, PhD, Stanford University complex by post-translational modi- Fayez Sarofim Fellow establishment of cancer-like epigenetic Pedro J. Batista, PhD* School of Medicine, Stanford fication” with Arshad B. Desai, PhD, Illinois “The molecular mechanism of landscapes” with John L. Rinn, PhD, Kenneth G. and Elaine A. Langone Fellow University of California, San Diego Yoko Shibata, PhD* poly(ADP-ribose) in the mitotic Harvard University, Cambridge “LincRNA dependent transcriptional Sabrina L. Spencer, PhD Howard Hughes Medical Institute Fellow Kimberley Evason, MD, PhD† spindle” with Timothy J. Mitchison, memory in cancer stem cells” with “Protein expression dynamics and “Identifying protein quality control Robert Black Fellow PhD, Harvard Medical School, Boston Josselin Milloz, PhD Howard Y. Chang, MD, PhD, Stanford thresholds in cell cycle commitment” mechanisms in the nucleus” with Richard “Hepatic stellate cell development and “Coordination of quiescence, meiosis and University School of Medicine, Stanford with Tobias Meyer, PhD, Stanford Uni- I. Morimoto, PhD, Northwestern role in carcinogenesis” with Didier Y.R. Young Kwon, PhD autophagy in the yeast Saccharomyces versity School of Medicine, Stanford University, Evanston Sean C. Bendall, PhD Stainier, PhD, University of California, “Identification and validation of new cerevisiae” with Sharad Ramanathan, PhD, Harvard University, Cambridge “Improved single-cell phospho-protein Alexander Ward, PhD* San Francisco Maryland regulators in Hpo signaling” with Nor- bert Perrimon, PhD, Harvard Medical signaling analysis of oncogenic progres- Howard Hughes Medical Institute Fellow Nicholas R. Guydosh, PhD Xi Huang, PhD* School, Boston Sumeet Sarin, PhD* sion in leukemia” with Garry P. Nolan, “Investigations of cancer signaling path- Howard Hughes Medical Institute Fellow “Functional significance of potassium Marion Abbe Fellow PhD, Stanford University School of ways in Drosophila olfactory system “Genome-wide regulation and dynamics channel EAG2 in medulloblastoma” Ying Lu, PhD* “A molecular mechanism of spatial Medicine, Stanford development” with Liqun Luo, PhD, of ribosome elongation” with Rachel with Lily Y. Jan, PhD, University of “Single-molecular study of ubiquitina- pattern formation in the vertebrate Stanford University School of Medicine, D. Green, PhD, The Johns Hopkins David K. Breslow, PhD* California, San Francisco tion/deubiquitination kinetics in cell retina” with Joshua R. Sanes, PhD, Stanford University, Baltimore Connie and Bob Lurie Fellow extracts” with Marc W. Kirschner, Harvard University, Cambridge Qiong Yang, PhD* Calvin H. Jan, PhD* PhD, Harvard Medical School, Boston “Dissecting the functions of phos- Chuan-Hsiang Huang, MD, PhD Cole Trapnell, PhD* Howard Hughes Medical Institute Fellow Rebecca Ridley Kry Fellow phoinositide lipids in the primary Harold L. Plotnick Fellow “Globally characterizing lncRNA “Nonlinear coupling of positive and “Studying translation with subcellular John R. Lydeard, PhD cilium” with Maxence V. Nachury, “Adaptation and gradient amplification oncogenes with next-generation tran- negative feedback loops in Xenopus resolution” with Jonathan S. Weissman, “Defining CRL4 substrates and regula- PhD, Stanford University School of in the chemotaxis signaling pathway” scriptomics” with John L. Rinn, PhD, early embryonic cycles” with James E. PhD, University of California, San Fran- tors through a systematic proteomic Medicine, Stanford with Peter N. Devreotes, PhD, The Harvard University, Cambridge Ferrell, MD, PhD, Stanford University cisco, California and functional analysis of DCAFs” with Johns Hopkins University, Baltimore Won-Suk Chung, PhD School of Medicine, Stanford Jeffrey Wade Harper, PhD, Harvard Ken S. Lau, PhD “Phagocytic capacity of glial cells and Dale Muzzey, PhD Medical School, Boston Rita L. Strack, PhD Robert Black Fellow their role in glioma progression” with Leon Y. Chan, PhD* Howard Hughes Medical Institute Fellow Lallage Feazel Wall Fellow “In vivo systems analysis of network Ben A. Barres, MD, PhD, Stanford Uni- Howard Hughes Medical Institute Fellow “Resolving general principles of cis “The mechanistic role of Upf1, Upf2, level signaling properties in the intes- versity School of Medicine, Stanford “Determining the mechanism of stress- translational regulation in eukaryotes and Upf3 in nonsense-mediated decay” tinal epithelium during acute inflam-

9 The Damon Runyon Cancer Research Foundation 2011 Annual Report 10 matory stimulus” with Kevin M. Haigis, William Rodney Hardy, PhD Maria Genander, PhD* PhD, and Douglas A. Lauffenburger, “Elucidation of signal transduction Dale F. and Betty Ann Frey Fellow PhD, Massachusetts General Hospital, pathways controlling oncogene-induced “Deciphering the mechanisms governing Damon Runyon-Rachleff Innovation Award Committee Boston senescence and their protective roles BMP regulated stem cell maintenance in against melanoma and breast cancer” hair follicles” with Elaine V. Fuchs, PhD, Taiowa A. Montgomery, PhD with Michael R. Green, MD, PhD, The Rockefeller University, New York Chair Todd R. Golub, MD Steven M. Larson, MD “Mechanisms of microRNA-directed University of Massachusetts Medical Ronald Levy, MD Investigator, Howard Hughes Chief, Nuclear Medicine Service RNA silencing” with Gary B. Ruvkun, School, Worcester Chief, Division of Oncology Medical Institute Donna and Benjamin M. Rosen PhD, Massachusetts General Hospital, Tennessee Professor of Medicine Director of the Cancer Program of the Chair in Radiology Boston Meelad M. Dawlaty, PhD Matthew F. Calabrese, PhD Stanford University School of Medicine Broad Institute of Harvard and MIT Memorial Sloan-Kettering Cancer Center “Deciphering the genetics and epigenetics Ian Y. Wong, PhD Howard Hughes Medical Institute Fellow Stanford, California Charles A. Dana Investigator in New York, New York of glioblastomagenesis by direct in vitro Merck Fellow “Ubiquitin interactions with a Human Cancer Genetics reprogramming of glioblastoma mul- Elizabeth H. Blackburn, PhD Jacqueline A. Lees, PhD “Suppressing cancer cell invasion and novel ubiquitin recognition motif” Dana-Farber Cancer Institute tiforme progenitor cells” with Rudolf Morris Herzstein Professor of Biology Associate Director, David H. Koch plasticity in 3D microenvironments” with Brenda A. Schulman, PhD, St. Jude Associate Professor of Pediatrics Jaenisch, MD, Whitehead Institute for and Physiology Institute for Integrative Cancer Research with Mehmet Toner, PhD, and Daniel Children’s Research Hospital, Memphis Harvard Medical School Biomedical Research, Cambridge Department of Biochemistry and Boston, Massachusetts Ludwig Scholar Irimia, MD, PhD, Massachusetts Gen- North Carolina Biophysics Professor of Biology eral Hospital, Boston Jared T. Nordman, PhD Erin A. Osborne, PhD* University of California, San Francisco Rachel D. Green, PhD Massachusetts Institute of Technology Yimon Aye, PhD Howard Hughes Medical Institute Fellow Howard Hughes Medical Institute Fellow San Francisco, California Investigator, Howard Hughes Cambridge, Massachusetts Robert Black Fellow “Cell cycle control of DNA replication in “When paths diverge: patterns and Medical Institute David Botstein, PhD Dan R. Littman, MD, PhD “Investigations toward mechanistic metazoans” with Terry L. Orr-Weaver, mechanisms of asymmetric cell divi- Professor, Department of Molecular Director, Lewis-Sigler Institute for Investigator, Howard Hughes understanding of human ribonucleotide PhD, Whitehead Institute for Biomedical sion” with Jason D. Lieb, PhD, The Uni- Biology and Genetics Integrative Genomics Medical Institute reductase -subunit-specific inhibition Research, Cambridge versity of North Carolina, Chapel Hill The Johns Hopkins University β Anthony B. Evnin Professor of Genomics Helen L. and Martin S. Kimmel by triapine” with JoAnne Stubbe, PhD, Baltimore, Maryland Missouri Wisconsin Princeton University Professor of Molecular Immunology Massachusetts Institute of Technology, Jihye Yun, PhD* Princeton, New Jersey Linda G. Griffith, PhD Skirball Institute of Biomolecular Cambridge Elizabeth M. Duncan, PhD “Transcription factors for engraftable Director, Biotechnology Process Medicine Howard Hughes Medical Institute Fellow Mark M. Davis, PhD hematopoietic stem cells” with James Engineering Center New York University School of Medicine Robert K. Bradley, PhD “Epigenetic regulation of cellular Investigator, Howard Hughes A. Thomson, VMD, PhD, Morgridge S.E.T.T. Professor of Biological and New York, New York “Investigating the splicing co-regulatory memory during planarian regeneration” Medical Institute Institute for Research, University of Mechanical Engineering network” with Christopher B. Burge, PhD, with Alejandro Sánchez Alvarado, PhD, Director of the Stanford Institute for Wisconsin, Madison Massachusetts Institute of Technology Stephen R. Quake, DPhil Massachusetts Institute of Technology, Stowers Institute for Medical Research, Immunity, Transplantation and Infection Cambridge Kansas City Cambridge, Massachusetts Investigator, Howard Hughes Stanford University School of Medicine Medical Institute * Initial Award Stanford, California Gregory J. Hannon, PhD Nadya Dimitrova, PhD Tiffany A. Reese, PhD Professor of Bioengineering Investigator, Howard Hughes Robert Blount Family Fellow “The immune response to latent gamma Co-Chair, Department of Bioengineering Napoleone Ferrara, MD Medical Institute “Functional characterization of the herpesvirus infection” with Herbert Stanford University Genentech Fellow Professor role of p53-regulated lincRNAs in W. Virgin, IV, MD, PhD, Washington Stanford, California Dale F. Frey Award Tumor Biology and Angiogenesis Cold Spring Harbor Laboratory tumorigenesis” with Tyler Jacks, PhD, University, St. Louis Genentech, Inc. Cold Spring Harbor, New York Kevan M. Shokat, PhD Massachusetts Institute of Technology, for Breakthrough South San Francisco, California Investigator, Howard Hughes Cambridge New Jersey Kenneth W. Kinzler, PhD Björn F.C. Kafsack, PhD Scientists Sanjiv Sam Gambhir, MD, PhD Medical Institute Daniel A. Heller, PhD Director, The Ludwig Center for Cancer Howard Hughes Medical Institute Fellow Director, Molecular Imaging Program Professor and Chair “Molecularly imprinted polymeric Genetics and Therapeutics “Density-dependent autocrine control Ken Cadwell, PhD Head, Nuclear Medicine Division Department of Cellular and Molecular antibodies for tumor-targeted siRNA Professor of Oncology and Director of gametocytogenesis in the virulent “Characterization of mice deficient Professor of Radiology and Bioengineering Pharmacology delivery” with Robert S. Langer, ScD, The Johns Hopkins University malaria parasite Plasmodium falciparum” in autophagy protein Atg16L1”, New Stanford University School of Medicine University of California, San Francisco Massachusetts Institute of Technology, Kimmel Cancer Center with Manuel Llinás, PhD, Princeton York University School of Medicine, Stanford, California San Francisco, California Cambridge Baltimore, Maryland University, Princeton New York, New York Nikhil S. Joshi, PhD Jung-Min Kee, PhD L. Stirling Churchman, PhD “Understanding the development and “Investigation of histidine phosphory- “Visualizing global transcription function of regulatory T cells in an lation in histone H4 through synthetic in vivo at nucleotide resolution”, Damon Runyon-Rachleff Innovation Award autochthonous mouse model of human protein chemistry” with Thomas W. Muir, Harvard Medical School, Boston, non-small cell lung cancer” with Tyler PhD, Princeton University, Princeton Massachusetts Jacks, PhD, Massachusetts Institute of Technology, Cambridge New York California Matthew G. Vander Heiden, MD, PhD* Joshua C. Munger, PhD Duncan J. Smith, PhD “Understanding the metabolic require- “Elucidating mechanisms of oncogenic Daniel Schmidt, PhD* Alexei A. Aravin, PhD* Howard Hughes Medical Institute Fellow ments of cancer cells” at the David metabolic manipulation” at the Univer- Norman B. Leventhal Fellow “Epigenetic regulation of transposable “Lagging strand synthesis and chromatin H. Koch Institute of Massachusetts sity of Rochester, Rochester “Molecular-targeted reagents to probe elements in cancer” at the California replication” with Iestyn Whitehouse, Institute of Technology, Pasadena Institute of Technology, Cambridge the role of ion channels in glioblastoma PhD, Memorial Sloan-Kettering Cancer Texas oncogenesis, proliferation, and migra- Center, New York Joshua E. Elias, PhD* Michigan Benjamin P. Tu, PhD* tion” with Edward S. Boyden, PhD, “How cancers cope with damage: a Ivan Maillard, MD, PhD and “A novel strategy for attacking tumors Massachusetts Institute of Technology, Jelena Nedjic, PhD proteomics approach” at Stanford Uni- Yi Zhang, MD, PhD based on the identification of a funda- Cambridge “Molecular mechanisms of leukemia versity School of Medicine, Stanford “Modulation of Notch signaling to mental carbon-source signal driving metastasis and tissue infiltration” with control graft-versus-host-disease and cell growth” at the University of Texas Iannis Aifantis, PhD, New York University Heather R. Christofk, PhD preserve the anti-tumor activity of Southwestern Medical Center, Dallas School of Medicine, New York “Regulation of cancer metabolism” at the alloreactive T cells” at the University of University of California, Los Angeles Michigan, Ann Arbor Washington Muneesh Tewari, MD, PhD Massachusetts New York “Cancer detection in ‘pre-diagnosis’ James E. Bradner, MD* Raffaella Sordella, PhD blood samples via microparticle-asso- “Targeting epigenetic readers as cancer Island Outreach Foundation Innovator ciated RNAs” at the Fred Hutchinson therapy” at the Dana-Farber Cancer “Characterization of Erlotinib resistant, Cancer Research Center, Seattle Institute, Boston Mesenchymal and Metastatic (EMM) cells present in naïve lung tumors prior John L. Rinn, PhD to treatments” at Cold Spring Harbor “The functional roles of large inter- Laboratory, Cold Spring Harbor genic non-coding RNAs in cancer” at Harvard University, Cambridge

11 The Damon Runyon Cancer Research Foundation 2011 Annual Report 12 Damon Runyon Clinical Investigator Award Committee Damon Runyon Clinical Investigator Awards

Chair Patricia A. Ganz, MD Michael D. Prados, MD, FACP California New York Washington Richard J. O’Reilly, MD Professor, Schools of Medicine and Professor in Residence of Jean Y. Tang, MD, PhD* Igor Matushansky, MD, PhD Marie Bleakley, MD, PhD* Chair, Department of Pediatrics Public Health Neurological Surgery “Mechanisms of acquired resistance to Gordon Family Clinical Investigator Richard A. Lumsden Chief, Pediatric Bone Marrow Director, Division of Cancer Prevention Charles B. Wilson, MD, Endowed Chair Hedgehog pathway inhibitors in basal “Implementing and imaging epigenetic Foundation Investigator Transplant Service and Control Research Director of Translational Research cell carcinomas” with Philip A. Beachy, based differentiation therapy for solid “Segregating the GVL effect from Claire L. Tow Chair in Pediatric Jonsson Comprehensive Cancer Center in Neuro-Oncology PhD, and Ervin H. Epstein, MD, tumors” with Carlos Cordon-Cardo, GVHD in humans” with Stanley R. Oncology Research University of California, Los Angeles Department of Neurological Surgery Stanford University, Stanford MD, PhD, Columbia University, New York Riddell, MD, Fred Hutchinson Cancer Memorial Sloan-Kettering Cancer Center Los Angeles, California University of California, San Francisco Research Center, Seattle Connecticut Zsofia K. Stadler, MD* New York, New York San Francisco, California Philip D. Greenberg, MD Tobias J.E. Carling, MD, PhD “Characterization of de novo germline Brian G. Till, MD Frederick R. Appelbaum, MD Director, Immunology Program Leslie L. Robison, PhD Doris Duke-Damon Runyon genetic alterations in cancer susceptibil- Pfizer Clinical Investigator Director, Clinical Research Division Member, Fred Hutchinson Cancer Member, St. Jude Faculty Clinical Investigator ity” with Kenneth Offit, MD, MPH, and “Optimization of adoptive immuno- Member, Fred Hutchinson Cancer Research Center Chair, Epidemiology and Cancer Control “Molecular genetics of endocrine tumor Michael H. Wigler, PhD, Memorial therapy for lymphoma using genetically Research Center Professor of Medicine and Immunology Associate Director for Cancer Prevention disease” with Richard P. Lifton, MD, Sloan-Kettering Cancer Center, New York modified CD20-specific T cells” with Head, Division of Medical Oncology University of Washington and Control Cancer Center PhD, and Robert Udelsman, MD, MBA, North Carolina Oliver W. Press, MD, PhD, Fred Hutchinson University of Washington School Seattle, Washington St. Jude Children’s Research Hospital Yale University School of Medicine, Cancer Research Center, Seattle of Medicine Memphis, Tennessee New Haven William Y. Kim, MD Hedvig Hricak, MD, PhD Seattle, Washington Merck Clinical Investigator Wisconsin Chair, Department of Radiology Louise C. Strong, MD Illinois “Molecular determinants of clinical Kevin R. Kozak, MD, PhD Carroll and Milton Petrie Chair Joseph R. Bertino, MD Sue and Radcliffe Killam Chair Vu H. Nguyen, MD response to EGFR inhibition in bladder Genentech Clinical Investigator Memorial Sloan-Kettering Cancer Center Chief Scientific Officer Professor of Cancer Genetics August M. Watanabe, MD, cancer” with Charles M. Perou, PhD, “Radiosensitization with antiangiogenic New York, New York The Cancer Institute of New Jersey Chief, Section of Clinical Cancer Genetics Clinical Investigator University of North Carolina, Chapel Hill therapy” with Paul M. Harari, MD, Interim Director, The Stem Cell M.D. Anderson Cancer Center “Organ-specific regulatory T cells as a William G. Kaelin, Jr., MD C. Ryan Miller, MD, PhD University of Wisconsin, Madison Institute of New Jersey The University of Texas targeted therapy for graft-versus-host Investigator, Howard Hughes Genentech Clinical Investigator University Professor of Medicine Houston, Texas disease” with Thomas F. Gajewski, This award program is currently sup- Medical Institute “Genomics-driven drug development and Pharmacology MD, PhD, The University of Chicago, ported by founding sponsor Eli Lilly Professor of Medicine for glioblastoma” with Charles M. UMDNJ-Robert Wood Johnson David A. Williams, MD Chicago and Company in addition to Genentech, Harvard Medical School Medical School Chief, Division of Hematology/Oncology Perou, PhD, and Terry Van Dyke, PhD, Merck and Company, Novartis Pharma- Dana-Farber Cancer Institute New Brunswick, New Jersey Director, Translational Research for Michigan University of North Carolina, Chapel Hill ceuticals Corporation, Siemens Medical Boston, Massachusetts Children’s Hospital Boston N. Lynn Henry, MD, PhD Texas Solutions, Inc. and Pfizer, Inc. David P. Carbone, MD, PhD Dana-Farber Cancer Institute Drew M. Pardoll, MD, PhD Lilly Clinical Investigator Harold L. Moses Chair in Cancer Research Leland Fikes Chair of Pediatrics Ralph J. DeBerardinis, MD, PhD* * Initial Award Director, Cancer Immunology Program “Pain processing pathway analysis Director, Specialized Program of Research Harvard Medical School “Translational studies in cancer Sidney Kimmel Comprehensive in aromatase inhibitor-associated Excellence in Lung Cancer Boston, Massachusetts metabolism” with Helen H. Hobbs, MD, Cancer Center musculoskeletal syndrome” with Daniel Ingram Professor of Cancer Research University of Texas Southwestern Abeloff Professor of Oncology F. Hayes, MD, University of Michigan, Professor of Medicine and Cancer Biology Medical Center, Dallas The Johns Hopkins University Ann Arbor Vanderbilt-Ingram Cancer Center School of Medicine Utah Vanderbilt University Minnesota Baltimore, Maryland Joshua D. Schiffman, MD* Nashville, Tennessee Andrew L. Feldman, MD “Microsatellite length and integrin signal- David R. Piwnica-Worms, MD, PhD “Investigation of IRF4 as a therapeutic Dennis A. Carson, MD ing as risk factors for Ewing’s Sarcoma” Director, Molecular Imaging Center target in T-Cell lymphomas” with Professor Emeritus with Stephen L. Lessnick, MD, PhD, Professor of Developmental Stephen M. Ansell, MD, PhD, and Ahmet Department of Medicine University of Utah, Salt Lake City Biology and Radiology Dogan, MD, PhD, Mayo Clinic, Rochester Moores Cancer Center Washington University School University of California, San Diego of Medicine La Jolla, California St. Louis, Missouri Bruce A. Chabner, MD Kornelia Polyak, MD, PhD Clinical Director Damon Runyon Clinical Investigator Award Associate Professor of Medicine Massachusetts General Hospital Department of Medical Oncology Cancer Center Continuation Grants Dana-Farber Cancer Institute Professor of Medicine Harvard Medical School Harvard Medical School Boston, Massachusetts Boston, Massachusetts Colorado Andrew T. Chan, MD, MPH Elahe A. Mostaghel, MD, PhD Douglas K. Graham, MD, PhD “Molecular imaging of colorectal Genentech Clinical Investigator Novartis Clinical Investigator neoplasia” with Charles S. Fuchs, MD, “Defining and exploiting molecular “Novel biologically targeted therapy MPH, and Ralph Weissleder, MD, PhD, mechanisms of androgen metabolism against the Mer receptor tyrosine Massachusetts General Hospital, Boston for prostate cancer therapy” with Peter kinase in the treatment of pediatric S. Nelson, MD, Fred Hutchinson Cancer New Jersey ALL” with James V. DeGregori, PhD, Research Center, Seattle and Sue Gail Eckhardt, MD, University Vassiliki Karantza, MD, PhD The Continuation Grant Program is of Colorado Denver, Aurora “Autophagy as a therapeutic target in breast cancer treatment” with Robert supported by the William K. Bowes Jr. Massachusetts S. DiPaola, MD, UMDNJ/Robert Wood Foundation, and Connie and Bob Lurie. Rachael A. Clark, MD, PhD Johnson Medical School, New Brunswick “Reversing immune evasion in human squamous cell carcinomas of the skin” Washington with Thomas S. Kupper, MD, Brigham Colleen S. Delaney, MD, MSc and Women’s Hospital, Boston Novartis Clinical Investigator “Notch-mediated ex vivo expansion of Catherine J. Wu, MD cord blood progenitors for hematopoi- “Immune-targeted leukemia antigens etic cell transplantation” with Irwin D. for eradication of CML stem cells” with Bernstein, MD, and Frederick R. Ap- Jerome Ritz, MD, Dana-Farber Cancer pelbaum, MD, Fred Hutchinson Cancer Institute, Boston Research Center, Seattle

13 The Damon Runyon Cancer Research Foundation 2011 Annual Report 14 Erin A. Osborne, PhD* Merck Fellows Clinical Investigators The University of North Carolina Gabriel C. Lander, PhD Gordon Family Clinical Investigator Named Awards Chapel Hill, North Carolina Lawrence Berkeley National Laboratory Igor Matushansky, MD, PhD Berkeley, California Columbia University Yoko Shibata, PhD New York, New York The following awards are funded by dedicated supporters of the Damon Runyon Cancer Research Foundation Northwestern University Wan-Jin Lu, PhD Evanston, Illinois Stanford University School of Medicine Richard A. Lumsden who have generously endowed an award in perpetuity or sponsored an individual Damon Runyon scientist: Stanford, California Foundation Investigator Duncan J. Smith, PhD Marie Bleakley, MD Memorial Sloan-Kettering Cancer Center Fellows Dennis and Marsha Dammerman Fellow* Christopher J. Hale, PhD Maurizio Righini, PhD Fred Hutchinson Cancer Research Center New York, New York Amgen Fellow Sarah E. Ewald, PhD University of California University of California Seattle, Washington Berkeley, California Costas A. Lyssiotis, PhD Stanford University School of Medicine Los Angeles, California Ilan Wapinski, PhD August M. Watanabe, MD Beth Israel Deaconess Medical Center Stanford, California Harvard Medical School Ian Y. Wong, PhD Clinical Investigator Kristina M. Herbert, PhD Boston, Massachusetts Boston, Massachusetts Massachusetts General Hospital Vu H. Nguyen, PhD Fraternal Order of Eagles Fellow* Yale University Boston, Massachusetts The University of Chicago Marion Abbe Fellow* James P. Scott-Browne, PhD New Haven, Connecticut Alexander Ward, PhD Chicago, Illinois Sumeet Sarin, PhD* La Jolla Institute for Allergy Stanford University School of Medicine Simon Jenni, PhD Philip O’Bryan Harvard University and Immunology Stanford, California A number of Clinical Investigators Harvard Medical School Montgomery Jr., MD, Fellow* Cambridge, Massachusetts La Jolla, California are named in recognition of generous Boston, Massachusetts Dong Yan, PhD Deniz Simsek, PhD support from Eli Lilly and Genentech, Robert Black Fellows Harvard Medical School University of California Dale F. and Betty Ann Frey Fellow* Inc.; Merck and Company; Novartis Phar- Yimon Aye, PhD Björn F.C. Kafsack, PhD Boston, Massachusetts San Francisco, California Maria Genander, PhD maceuticals Corporation; and Pfizer, Inc. Massachusetts Institute of Technology Princeton University The Rockefeller University Norman B. Leventhal Fellow Please refer to page 14 for a list of those who Cambridge, Massachusetts Princeton, New Jersey Qiong Yang, PhD New York, New York Stanford University School of Medicine Daniel Schmidt, PhD hold this distinction. Yumi Kim, PhD Kimberley Evason, MD, PhD Stanford, California Massachusetts Institute of Technology Howard Hughes Medical Institute Fellows University of California University of California Cambridge, Massachusetts Innovators Orkun Akin, PhD Berkeley, California Hyun Youk, PhD* San Francisco, California Island Outreach Foundation Innovator University of California University of California Harold L. Plotnick Fellow Liana F. Lareau, PhD Raffaella Sordella, PhD Tom A. Hartl, PhD Los Angeles, California San Francisco, California Chuan-Hsiang Huang, MD, PhD Stanford University School of Medicine Stanford University School of Medicine The Johns Hopkins University Cold Spring Harbor Laboratory Stanford, California Matthew F. Calabrese, PhD Stanford, California Harry Kriegel Fellow Baltimore, Maryland Cold Spring Harbor, New York St. Jude Children’s Research Hospital Scott J. Valastyan, PhD Rebecca S. Mathew, PhD The Damon Runyon-Rachleff Innovation David G. Hendrickson, PhD Memphis, Tennessee Harvard Medical School Fayez Sarofim Fellow* Harvard Medical School Award is funded by the generous support Harvard University Boston, Massachusetts Kristin A. Krukenberg, PhD Boston, Massachusetts of Andrew and Debra Rachleff. Please Cambridge, Massachusetts Leon Y. Chan, PhD Harvard Medical School refer to page 12 for a list of Rachleff University of California Rebecca Ridley Kry Fellow* Boston, Massachusetts Raymond E. Moellering, PhD Innovators. Ken S. Lau, PhD Berkeley, California The Scripps Research Institute Calvin H. Jan, PhD Massachusetts General Hospital Lallage Feazel Wall Fellow* La Jolla, California University of California * In perpetuity Boston, Massachusetts Jianfu (Jeff ) Chen, PhD San Francisco, California Rita L. Strack, PhD University of Colorado Denver, Aurora Dale Muzzey, PhD The Johns Hopkins University Lara C. Skwarek, PhD Aurora, Colorado University of California Kenneth G. and Elaine A. Baltimore, Maryland University of California San Francisco, California Langone Fellow* The Jake Wetchler Berkeley, California Elizabeth M. Duncan, PhD Pedro J. Batista, PhD Foundation Fellow Stowers Institute for Medical Research Jared T. Nordman, PhD Stanford University School of Medicine Hua Lu, PhD Robert Blount Family Fellow Kansas City, Missouri Whitehead Institute for Stanford, California Nadya Dimitrova, PhD Biomedical Research The Scripps Research Institute Massachusetts Institute of Technology Nicholas R. Guydosh, PhD Cambridge, Massachusetts Connie and Bob Lurie Fellow* La Jolla, California Cambridge, Massachusetts The Johns Hopkins University David K. Breslow, PhD Suzanne and Bob Wright Fellow* Baltimore, Maryland Stanford University School of Medicine Nathan D. Thomsen, PhD Stanford, California University of California San Francisco, California

15 The Damon Runyon Cancer Research Foundation 2011 Annual Report 16 Ms. Penelope P. Harris Burroughs Wellcome Fund Patrick William Gray, PhD Our Contributors Laura Hartenbaum Breast Cancer Ms. Tanya Burrow Mr. and Mrs. Vernon Grizzard Foundation, Inc. The CAC Group Mr. and Mrs. Andrew S. Grove Joe & Pasena Maroun Family Mr. and Mrs. Patrick J. Callan Mr. and Mrs. David Lee Hamilton Foundation The Damon Runyon Cancer Research Foundation acknowledges the generosity and support of the many Estate of Robert J. Cameron Mr. I.H. Hammerman II Maryland Charity Campaign individual, corporate, and foundation donors who supported our brilliant researchers through gifts to the Mrs. Christina E. Carroll Mr. and Mrs. William B. Harrison Foundation from July 1, 2010 to June 30, 2011.* Those whose individual lifetime giving is $100,000 or Maverick Capital Charities William L. Carroll, MD Ms. Denny Hartman more are highlighted. We are especially grateful to these extraordinarily generous and committed donors. Sanford W. Morhouse, Esq. The Chubb Corporation Mr. and Mrs. Robert Haupt Mr. and Mrs. Warren K. Myer Ms. Joni L. Walser and Miss Happy G. Hawn $1,000,000 OR MORE Goldman Sachs The Leo Model Foundation, Inc. New York State Industries for the Mr. Andrew B. Church Lenore Hecht Foundation, Inc. Harvey Family Fund Grand Aerie Fraternal Mr. Paul M. Montrone, Perspecta Trust Disabled (NYSID) Estate of Laurelia M. Clifford Mr. and Mrs. Robert M. Hess Howard Hughes Medical Institute Order of Eagles Eugene & Mary Murphy Mr. and Mrs. Rahn Pitzer Mr. and Mrs. Jay L. Cohan Mr. Chris Hoerenz Debra and Andrew S. Rachleff Hettinger Foundation Charitable Gift Fund Mr. and Mrs. Roy Plum Mr. Laurence W. Cohen Dr. and Mrs. Howard A. Hoffman $100,000 – $999,999 Estate of Walter Tom Holmes Mr. Steven S. Payson Dr. and Mrs. John W. Rowe Errol M. & Gladys Cook Fund Mr. and Mrs. Edward E. Hood Jr. Amgen, Inc. Mr. and Mrs. Jay Ireland Mr. and Mrs. Robert P. Quinn Roberta & Ernest Scheller, Jr. Mr. Milton Cooper Ms. Sandra J. Horbach Angelo, Gordon & Co. Mr. and Mrs. David G. Marshall Raiff Foundation Family Foundation Mr. and Mrs. Michael J. Cosgrove Mr. and Mrs. Daniel Huber Anonymous MetLife Foundation Mr. and Mrs. Arthur Samberg Stewart Senter, Inc. Mr. and Mrs. Michael J. Crames Mr. and Mrs. Wayne M. Hummel Anonymous Morgan Stanley Ms. Karen D. Seitz Ms. Suzy Sang Shechtman Bonni Curran, MD Mr. Andre Hunter Anonymous Estate of Bernice Natkowski Henry J. & Kathleen Singer Estate of Beatrice G. Smedley Family Foundation Mrs. Mikell M. Smith Mr. Lawrence H. David Mr. Patrick M. Hurless and Terry and David Beirne The Nielsen Company Ms. Megan K. Curran-Hurless Charles Spear Charitable Trust The Richard C. and Theresa P. Smith Mr. Jeffrey L. Davis Robert Black Charitable Foundation Mrs. Julia R. Plotnick ING Foundation Barbara & Peter Strauss Memorial Fund Dr. Davis and Dr. Chien Fund William K. Bowes, Jr. Foundation Estate of William M. Poindexter, Esq. Instinet Group, LLC Philanthropic Fund Mr. James D. Staley Mr. David Dembo Celgene Corporation Pyramid Hotel Group Mr. Thomas C. Israel The T.F. Trust Structure Tone, Inc. Mr. and Mrs. Pierre J. de Vegh Estate of Adrienne & Mr. and Mrs. Fred Seigel Johnson & Johnson Matching Tzedakah Foundation Daniel P. & Grace I. Tully Deborah Coleman and Harry Chamberlain Select Equity Group Gifts Program White Rose Charitable Trust Timothy W. Diggins Clayman Family Foundation Tishman Speyer Mr. and Mrs. Norman M. Johnson Wickham Family Fund The Turk Family Foundation Dr. Craig A. Drill Leon & Toby Cooperman Foundation Mrs. Mary Vetter Johnson-Miller Foundation Mr. and Mrs. Gary Wolf Ueberroth Family Foundation Doris Duke Charitable Foundation Lora S. Gallegher Trust Mr. and Mrs. Stephen Joseph Walgreens Mr. Scott Urdang Mrs. Willis H. DuPont Patrick J. Gallegher Trust $5,000 – $9,999 Mr. and Mrs. James H. Kimenker $10,000 – $24,999 Mrs. Carolyn R. Aller Venable Foundation Estate of Rowena J. Easop Genentech, Inc. 24 Hour Fitness Mr. and Mrs. William B. King The Howard Bayne Fund Mr. and Mrs. Gregg Wasser Mr. and Mrs. Don C. Eddington Sally and Michael Gordon Robert Alexander, CB Richard Ellis, Inc. Mr. and Mrs. Douglas M. Kinney Mr. and Mrs. Steven H. Berg Estate of Emma Werk Mr. Sanford B. Ehrenkranz Independent Charities of America Mr. Lee P. Klingenstein/ Almar Foundation/Mr. and Mrs. Estate of Winifred Wiederkerr Alex Engardt Roofing & Siding Island Outreach Foundation Albert Hess Mr. Richard L. Bowen Klingenstein Fund Chelsea Lighting, Inc. Mr. and Mrs. Robert C. Wright Mr. Peter Erichsen and Mr. and Mrs. Jeremy R. Kramer Estate of Burton H. Ladensohn Anonymous Mr. David Palumb City of Baltimore Combined $1,000 – $4,999 Estate of Marie Kronman Sherry and Alan Leventhal Aurora Capital Group Dr. John W. Espy Family Foundation Charity Campaign Ms. Elaine M. Addis Mr. and Mrs. William L. Kronthal Mrs. Barbara Lieb Baumstein Estate of Edward & Bozena Etnyre Lilly USA, LLC Mr. and Mrs. Martin J. Cohen Mr. and Mrs. O. Kelley Anderson, Jr. Lafer Equity Investors, LP Sol & Margaret Berger Foundation Thomas J. Fahey, Jr., MD Richard A. Lumsden Foundation Community Health Systems, Inc. Anonymous Mr. W. Loeber Landau Mr. William Cortelyou Mr. and Mrs. Frank Feinberg Mr. W. Barry McCarthy, Jr. Creative Dimensions Mr. Joseph Ansanelli Dr. and Mrs. Melvin Landew Mr. and Mrs. James J. Costello Ms. Leslie Ferrone Merck & Company, Inc. Ms. Dorothy D’Amato Apple Lane Foundation Ms. Ellen S. Lane Robert M. Currey & Associates, Inc. Mr. Ralph A. Fields Millennium: The Takeda Mr. and Mrs. Michael DeDomenico Mrs. Joan Armour-Mendell William D. & E.M. Lane Foundation Debevoise & Plimpton LLP Ms. Ilene Fine and Dr. Jay Pomerance Oncology Company Mr. and Mrs. Frank Doyle Atlantic Trust Ms. Janice R. Lane Dewey & LeBoeuf LLP Mrs. Roberta Fine Pfizer Inc Mr. and Mrs. Larry D. Droppa Mr. Arthur S. Bahr Mr. and Mrs. Ralph R. Layman Lorraine and Bill Egan LaRue S. & Walter F. Fisher $50,000 – $99,999 Echlin Foundation Bank of America Matching Gifts Mr. and Mrs. Richard LeFrak Erlbaum Family Foundation Memorial Trust Bloomberg L.P. Edwards Angell Palmer & Dodge LLP Mr. F. Harlan Batrus Mrs. Tova Leidesdorf First American Title Robert F. Fisher, PhD Connie and Bob Lurie Eisai Pharmaceuticals Mr. and Mrs. Roger Bauman Mrs. Ann R. Lermer Insurance Company Mr. William Fisher Mr. and Mrs. James M. Emanuele Mr. and Mrs. John R. Berkley Levin Capital Strategies, LP $25,000 – $49,999 Goulston & Storrs PC Mr. Ronald Forster Mr. and Mrs. Lawrence Altman Endo Pharmaceuticals Inc. Mr. Jordan Berman Estate of Franklin S. Lewis Greenberg Traurig Ms. Mary Ann Frenzel John M. and Judy Hart Angelo Mr. and Mrs. Michael C. Erlbaum Donald P. Biek, PhD David M. Livingston, MD Mr. Steve Hayden Mrs. Mary Ann Fribourg Anonymous Mr. Steven Esrick Mr. and Mrs. Bruce J. Bier Estate of Wanda Livingston Irma T. Hirschl Charitable Trust Elaine V. Fuchs, PhD Barney Family Foundation Ms. Erica K. Evans Mr. and Mrs. Eugene K. Bolton LKC Foundation Mr. Clair Howey/Maryann Howey Gabelli Funds Mrs. Joellen Fisher Blount Memorial Fund Mrs. Phyllis Farleigh Estate of William Borea Mr. Carl M. Loeb III Estate of Lawrence J. Gazzolo Bossidy Foundation Interco Charitable Trust Drs. Sheryl and Randall Feingold Mr. and Mrs. Thomas J. Bracken William Maidman Family, LP Ms. Janet Gelbart Eastdil Secured Estate of Mamie Kaffel Friedman Family Foundation Mr. William S. Brady Mr. Richard H. Maidman General Electric Foundation Estate of Rita Eisenberg Mr. Steven A. Kandarian Estate of Elsinore Machris Gilliland brightroom, Inc. Henri Emile Maisin, MD, PhD Goldstone Fund, Inc. Emigrant Bank Mr. and Mrs. Kenneth G. Langone Mr. and Mrs. James Gould Judy Buechner Advised Fund Mr. James H. Manges Todd R. Golub, MD EOG Resources, Inc. Thomas H. Lee and Ann Tenenbaum Jon & Mindy Gray Family Foundation Steven J. Burakoff, MD Mr. and Mrs. Joseph Mannello Mr. and Mrs. Peter Grad Betty Ann and Dale Frey Mr. Edmund S. Burke Estate of Marion Manuel Mr. and Mrs. Henry Mannix III Mr. and Mrs. Scott Greenstein Mr. H. Devon Graham, Jr. GE Asset Management Mr. Jim Mara Gordon H. & Karen M. Millner Robert E. Griffin, Jr., Mrs. Genevieve Burlingame Ms. Elizabeth A. Gray Ms. Margaret A. Gilliam Family Foundation Cushman & Wakefield Mr. and Mrs. Charles B. Marqusee

17 The Damon Runyon Cancer Research Foundation 2011 Annual Report 18 Andrew C. Marsh Memorial Fund Mr. and Mrs. D. Paul Rittmaster Mr. and Mrs. Melville Straus Mr. and Mrs. Gerald M. Marshall Mr. Mike Robbins The Stuart Family Foundation Damon Runyon Advisors Mrs. William Matheson Mr. and Mrs. Bruce S. Robinson Mr. Richard Sullivan The August Mattheyses Fund of the Rockefeller Financial Services Inc. Carolyn K. Suzuki, PhD Community Foundation of New Jersey Mr. and Mrs. Gary R. Rockhold Ms. Judy C. Swanson The Damon Runyon Advisors act as special advisors to the Foundation in their areas of expertise MB Real Estate Gary N. Rogers, PhD Mr. and Mrs. Sanford V. Teplitzky and are committed to expanding awareness about our important work to the next generation of supporters. Jennifer M. McCafferty-Cepero, PhD Mr. Christopher Romanyshyn Thomas & Associates CPA, P.C. Ms. Lisa McInerney Jill E. Bargonetti-Chavarria, PhD Jeremy Lack, PhD Annemarie Schoepfer Ronson Family Philanthropic Fund Mr. and Mrs. Michael J. Tine Professor of Biological Sciences Principal Senior Partner, Planning Mr. John McStay Mr. and Mrs. Francis C. Rooney, Jr. Mr. John L. Tishman Hunter College and The Graduate Center New Leaf Venture Partners Ogilvy & Mather Worldwide Mrs. Janet Menn Edwards City University of New York Mrs. Miriam K. Rothenberg Mr. and Mrs. Donald W. Torey Henry Mannix III Marcel R. M. van den Brink, MD, PhD Mr. Richard Menschel Mr. Philip R. Rotner John & Carol Trani Fund Michael J. Bossidy Vice President Head, Division of Hematologic Oncology The Messinger Foundation, Inc. Dr. Howard S. Rudominer Truist Managing Director Kelso & Company Memorial Sloan-Kettering Cancer Center Mr. Louis J. Mezzina Head of U.S. Distribution Mr. Mark T. Rutkowski UBS Matching Gift Program JPMorgan Securities, Inc. Gerald M. Marshall Gary Wolf Mrs. Julie Michelena Sanderson Family Charitable Fund Visa GivingStation President and Chief Executive Officer Managing Director Mr. and Mrs. Fred Middleton Deborah Clayman Amerimar Enterprises, Inc. Angelo, Gordon & Co. Dr. Lief Sannen and Mr. Larry Wieman Mr. and Mrs. H. Mitchell Watson, Jr. Clayman Family Foundation Mrs. Payne W. Middleton Mr. Norman R. Schlanger Mr. William R. Weinberg Christine L. O’Donnell Mr. and Mrs. Fred H. Miller Erica K. Evans Vice President and Senior Mr. Alan S. Schneier Mr. and Mrs. Leo F. Wells III Senior Vice President Program Officer Mintz Levin Ms. Linda Schoenthaler Mr. and Mrs. David W. Wiederecht ING Investment Management Foundation Advisory Services Mr. and Mrs. Charles H. Murphy III Bank of America Merrill Lynch Mendon F. Schutt Family Fund Mr. Henry Wilf Karen Fang Mr. and Mrs. John H. Myers Marvin & Donna Schwartz Winter Management Corporation Head of Cross Asset Solutions and John M. Olivieri National Mah Jongg League, Inc. Foundation Mr. and Mrs. Rod C. Wood Strategies for Global Markets Partner Bank of America Merrill Lynch White & Case LLP Dr. Herbert E. Natof Mr. Marvin C. Schwartz H.R. Young & Betty G. Young Fund Mr. and Mrs. Thomas J. Neff Robert J. Seifer Cancer Research Robert C. Young, MD Foundation L.M. Newman Family Foundation Mr. and Mrs. Michael J. Zaccagnino Ms. Ethel G. Sensenig Mr. and Mrs. Michael J. Nohe Mr. Steven Zalkind Mrs. Felice K. Shea Premier Circle 2011 Novartis Institutes for Mr. and Mrs. J. Thomas Zusi Biomedical Research Abraham I. & Jean Sherr Mrs. William J. Oppenheim Foundation, Inc. * Our donor lists are checked carefully. The Broadway Premier Circle is a group of committed Damon Runyon Broadway Tickets customers Ms. Paula S. Oreck The Sidewater Family Foundation, Inc. However, if you have any corrections or who have made a special donation in support of cancer research. The Premier Circle offers members Mrs. Joann Oreffice Joseph M. Siegman Family Foundation questions, please call 877.722.6237. priority access to tickets and other benefits. Richard J. O’Reilly, MD Mr. and Mrs. David M. Silfen The full pledge amount is listed in the Mr. Robert J. Osterhus Samuel C. Silverstein, MD year the pledge is made. In subsequent Ms. Sandye Berger Ms. Lisa McInerney Mr. and Mrs. Kenneth M. Stabler Mr. and Mrs. Ronald E. Parr Mr. and Mrs. Fredric C. Slater years, actual pledge payments are listed. Bonni Curran, MD Mr. and Mrs. Charles H. Murphy III Mrs. Barbara W. Stern Mr. Gerald S. Payne Mr. and Mrs. Jeffrey Q. Smith Mr. James L. Currie Mr. James K. Murray, Jr. Mr. and Mrs. Michael J. Tine Pells Mayton Foundation, Inc. Estate of Mildred A. Smith Ms. Dorothy D’Amato Ms. Sue Nager Ms. Dina Treanor and Mr. Jeffrey Taschler Mr. and Mrs. E. Lee Perry Mr. Andrew Solomon Mr. and Mrs. James M. Emanuele Mr. Sheldon Pressler The Turk Family Foundation of the Mr. and Mrs. Leonard Pfau Mr. Andrew Sommers Ms. Mary Ann Frenzel Ms. Virginia H. Randt Jewish Community Fund Mr. and Mrs. Edwin L. Phelps Mr. and Mrs. Alfred Spain Ms. Penelope P. Harris Mr. Philip R. Rotner Mr. Scott Urdang Dr. Joseph Piorkowski Mr. and Mrs. Kenneth M. Stabler Mr. and Mrs. Peter J. Wasserman Mr. Richard Poll Mr. Fred Stein Mr. and Mrs. Robert Haupt Mr. and Mrs. Ernest Scheller, Jr. Mr. Benjamin J. Winter Pratt Industries, Inc. Steiner Sports Memorabilia Mr. and Mrs. James H. Kimenker Abraham I. & Jean Sherr Foundation, Inc. Mr. Sheldon Pressler Mrs. Barbara W. Stern Ms. Ellen S. Lane Mr. and Mrs. Henry J. Singer Mr. Jerry Pyle Mrs. Linda B. Stern Mr. and Mrs. Gerald M. Marshall Harold K. Raisler Foundation Bruce W. Stillman, PhD, FRS Mr. and Mrs. Carl A. Ressa Jr. Mr. David H. Strassler Mr. Philip A. Riordan Martha Washington Straus – Harry Straus Foundation, Inc. Discovery Society 2011

Discovery Society members are valued supporters who have provided for the Damon Runyon Cancer Research Foundation through planned gifts. These donations provide a vital source of support and fuel future breakthroughs against cancer.

Ms. Elaine M. Addis Mr. and Mrs. William C. Hines Mr. and Mrs. Ronald E. Parr Ms. Ann K. Cote Mrs. Rebecca R. Kry Mr. Seymour Rosenheck Mrs. Phyllis Farleigh Mr. and Mrs. Leo LoFrisco Ms. Phoebe H. Showers Robert F. Fisher, PhD Mr. and Mrs. Charles B. Marqusee Mrs. Carol H. Stix Ms. Mary Ann Frenzel Mr. D.G. Mitchell Ms. Rose Vaccariello Mr. Rick J. Govern Ms. Martha R. Nortner Mr. and Mrs. Arthur Walker

19 The Damon Runyon Cancer Research Foundation 2011 Annual Report 20 “The challenge for cancer is still strong, but there is new progress being made. The science is Financial Summary complex and demanding, but I think it’s really going to pay off very handsomely. We’re at this kind of tipping point for cancer research, where we can truly start thinking about how to Fiscal Year 2011 harness all of this knowledge—medical, biomedical, treatment—to prevent disease entirely or intercept it earlier.“ As in previous years, the financial activities of the Damon Runyon Cancer Research Foundation were audited by McGladrey and Pullen, LLP. For our complete audited financial statements, please Elizabeth H. Blackburn, PhD visit our website at www.damonrunyon.org. Damon Runyon-Rachleff Innovation Award Committee Member Professor of Biology and Physiology University of California, San Francisco 2010 2011 “We are entering an exciting and unprecedented new era in translational cancer research. Overall Financial Health Total Assets $92,257,373 $106,487,205 Basic lab studies and new genome-scale technologies are creating optimism that we can actually Summary of Balance Sheets understand the biological complexity in different patients’ tumors. We have already seen successes The Damon Runyon Cancer Research against cancers that were considered incurable 5 years ago (for example, multiple myeloma, Total Foundation remained fiscally strong in FY Liabilities $15,513,605 $17,214,923 advanced prostate cancer, and melanoma). These efforts are completely changing the way we do 2011. Thanks to our donors, our revenues cancer research: the new science is being performed by highly collaborative, multi-disciplinary grew, enabling us to expand our scientific Total teams of basic and clinical researchers in close coordination with industrial partners. We have program funding. Net Assets $76,743,768 $89,272,282 never been this excited or confident about our ability to have major, transformative impact on cancer mortality.” David J. McConkey, PhD Damon Runyon Fellowship Award Committee Member Where Our Money Goes Where Our Support Director of Urological Research Summary of Operating Expenses Comes From Professor of Cancer Biology and Urology University of Texas MD Anderson Cancer Center General Administration

4.9% Fundraising Damon Runyon Bequests Broadway Tickets “It’s an incredibly important year in realizing the promises of new innovation in cancer 11.4% and Trusts Donated Services research. For the first time, the government reported that a patient diagnosed with cancer has a Misc. Income two-thirds likelihood of being alive and cancer-free five years later. That is a great accomplishment 83.7% Award in a generation. The excitement going forward is that we can combine new approaches—turning Programs off genes that cause cancer while hiring the immune system to clean up the rest of the damage— Draw from Investments and turn them into a cure.” Craig B. Thompson, MD Contributions President and Chief Executive Officer Memorial Sloan-Kettering Cancer Center

Damon Runyon has received an outstanding 4 stars from Charity Navigator, Total Operating Expenses: Total Operating Revenue: indicating that the Foundation “exceeds industry standards and outperforms most charities $13.8 Million $15.1 Million in its Cause.”

2011 Annual Report 22

21 The Damon Runyon Cancer Research Foundation One Exchange Plaza 55 Broadway, Suite 302 New York, New York 10006 1.877.7CANCER T 212.455.0500 F 212.455.0509 www.damonrunyon.org