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(12) United States Patent (10) Patent No.: US 8,771,763 B2 Asiedu Et Al

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(12) United States Patent (10) Patent No.: US 8,771,763 B2 Asiedu Et Al US00877 1763B2 (12) United States Patent (10) Patent No.: US 8,771,763 B2 Asiedu et al. (45) Date of Patent: Jul. 8, 2014 (54) COMPOSITION FORTREATING AIDS AND 2004 as R 38 8. AsSiedlu et al.al ASSOCATED CONDITIONS 2010/0266715 A1 10, 2010 Asiedu et al. (71) Applicant: Ward-Rams. Inc., Bridgewater, NJ FOREIGN PATENT DOCUMENTS WO 98.25633 A2 6, 1998 (72) Inventors: William Asiedu, Accra (GH); Frederick WO 9951249 A1 10, 1999 Asiedu, Accra (GH); Manny Ennin, W E. A. 3.38. Accra (GH); Michael Nsiah Doudu, Accra (GH); Charles Antwi Boateng, OTHER PUBLICATIONS Accra (GH); Kwasi Appiah-Kubi, Accra (GH); Seth Opoku Ware, Accra (GH): "Alstonia. The Plant List.” http://www.theplantlist.org/brows/A? Debrah Boateng. Accra (GH): Kofi Apocynaceae/Alstonia, accessed May 9, 2013, 3 pages. Amplim, Accra (GH); William Owusu, “Anogeissus. The Plant List.” http://www.theplantlist.org/brows/A? Accra (GH); Akwete Lex Adjei, Combretaceae. Anogeissus, accessed May 9, 2013, 2 pages. Bridgewater, NJ (US) “Cleistopholis—The Plant List.” http://www.theplantlist.org/brows/ A? Annonaceae/Cleistopholis, accessed May 9, 2013, 2 pages. (73) Assignee: Wilfred-Ramix, Inc., Bridgewater, NJ “Combretum. The Plant List.” http://www.theplantlist.org/brows/ (US) A/Combretacaea/Combretum, accessed May 9 2013, 13 pages. “Dichapetalum—The Plant List.” http://www.theplantlist.org/ (*) Notice: Stil tO E. distic th t brows/A/Dichapetalaceae/Dichapetalum, accessed May 9, 2013, 7 patent 1s extended or adjusted under pageS. U.S.C. 154(b) by 0 days. "Gongronema. The Plant List.” http://www.theplantlist.org/brows/ A? Apocynaceae/Gongronema, accessed May 9, 2013, 2 pages. (21) Appl. No.: 13/949,613 "Strophanthus (plant genus)—Britannica Online Encyclopedia.” 1-1. http://www.britannica.com/EBchecked/topic/56953.5/Strophanthus, (22) Filed: Jul. 24, 2013 accessed May 9, 2013, 2 pages. O O “Uvariastrum. The Plant List.” http://www.theplantlist.org/brows/ (65) Prior Publication Data A? Annonaceae/Uvariastrum, accessed May 9, 2013, 2 pages. US 2014/OO23731 A1 Jan. 23, 2014 (Continued) Related U.S. Application Data Primary Examiner — Susan Hoffman (60) Division of application No. 12/828,956, filed on Jul. 1, (74) Attorney, Agent, or Firm – Frommer Lawrence & 2010, now abandoned, which is a continuation of Haug LLP; Marilyn Matthes Brogan: Kathleen N. Ehrhard application No. 10/902,993, filed on Jul.30, 2004, now applicationPat. No. 7,749,544, No. 10,241,973, which filedis aon continuation Sep. 12, 2002, of (7) ABSTRACT now abandoned. An Aids and associated conditions related to Aids treating (51) Int. Cl compositions is disclosed. The compositions comprise: a A. iK s6/2 (2006.01) medicament selected from an extract of at least one of the A6 IK 36/22 (2006.015 following plant families: Apocynaceae (Pleioscarpa Bicar A6 IK36/86 (2006.015 pellata); Annonaceae (Cleistopholis Patens); Dichapetal A6 IK 36/24 (200 6,015 aceae (Dichapetehan Madagasca Riense); Annoceae 52) U.S. C (Uvaristrum Pierreanum); Cynocynaceae (Strophantus Gra (52) jSpC 424f725 tus); Asclepiadaceae (Gongronema Latifolium); Combreta ... ." grrrrr. ceae (Combretum Racemosum); Apocynaceae (Alostonia (58) Field of Classification Search Boonei); Amaranthaceae (Alternanthera Pungens); Aroceae CPC ........................... A61K 36/00; A61K 2300/00 (Anchomanes Differmis); Cyperaceae (Seleria Voivinil); USPC . 424/725, 769 Anacardiaceae (Lannea Acida); Bignodaceae (Kigelia Afri See application file for complete search history. cana); Bombacaceae (Ceiba Pentanota); Anarcardiaceae (56) References Cited (Antrocaryon Micraster); Bombacaceae (Bombax Bounopo zense): Anarcardiaceae (Spondias Mombin); Caricaceae U.S. PATENT DOCUMENTS (Carica Papaya); a glyceryl ester of any of the foregoing extracts; a saponin of any of the foregoing extracts; an alka 4,761,286 A 8/1988 Hiji loid of any of the foregoing extracts; a protein of any of the 4,923,697 A 5, 1990 Albeck et al. foregoing extracts; a fat of any of the foregoing extracts; a 4,940,726 A 7, 1990 Pettit et al. 5,227,383 A 7, 1993 Clark et al. Sugar of any of the foregoing extracts; and any mixture of any 5,545,623 A 8, 1996 Matsumori of the foregoing. 5,607.673 A 3/1997 Bashengezi 5,919,460 A 7/1999 Ingram 6,132,725 A 10, 2000 Kadono et al. 2 Claims, No Drawings US 8,771,763 B2 Page 2 (56) References Cited Engler, A. et al., “Die Naturlichen: Pflanzenfamilien.” 1897, p. 349. Ginsberg, et al., “Challenges in tuberculosis drug research and devel OTHER PUBLICATIONS opment.” Nature Medicine, vol. 13, No. 3, Mar. 2007, pp. 290-294. Keshinro, O. O., “The Unconventional Sources of Ascorbic Acid in Akah, P. A. et al., “Evaluation of Nigerian Traditional Medicines: 1. the Tropics.” Nutrition Reports International, vol. 31, No. 2, Feb. Plants Used for Rheumatic (Inflammatory) Disorders,” Journal of 1985, pp. 381-387. Ethnopharmacology, vol. 42, 1994, pp. 179-182. Njoku, C. J. et al., “The Anthelmintic Activities of Pleiocarpa Atindehou, K. K. et al., “Evaluation of the Antimicrobial Potential of bicarpellata Leaf Aqueous Extract.” Fitoterapia, vol. 67, No. 4, 1996, Medicinal Plants from the Ivory Coast.” Phytotherapy Research, vol. 16, Aug. 2002, pp. 497-502. pp. 339-343. Boyom, F. F. et al., “Aromatic plants of tropical central Africa. Part Ojewole, J. A. O., “Studies on the Pharmacology of Echitamine, and XLIII: volatile components from Uvariastrum pierreanum Engl. Alkaloid from the Stem Bark of Alstonia boomei L. (Apocynaceae).” (Engl. & Diels) growing in Cameroon.” Flavour and Fragrance Jour International Journal of Crude Drug Research, vol. 22, No. 3, 1984, nal, vol. 18, 2003, pp. 296–298. pp. 121-143. Breteler, F. J., “Novitates Gabonenses 47. Another new Sanogo, R. et al., “Evaluation of Malian Traditional Medicines: Dichapetalum (Dichapetalaceae) from Gabon.” Adansonia, vol. 25. Screening for Antimicrobial Activity.” Phytotherapy Research, vol. No. 2, 2003, pp. 223-227. 12, 1998, pp. S154-S156. Calderón et al., “Evaluation of Diuretic Activity of Alteranthera Sultana, S. et al., “A Flavanone from Lannea acida.” Phytochemistry, pungens Extract in Rats.” Phytotherapy Research, vol. 11, 1997, pp. vol. 25, No. 4, 1986, pp. 963-964. 606-608. International Search Report for International Patent Application No. Duke, J. A. et al., “Handbook of Medicinal Herbs, Second Edition.” PCT/US2003/028295 mailed May 17, 2004. CRC Press, USA, 2002, pp. 364, "Abbreviations” section, 815-819, International Preliminary Report on Patentability for International 821-827. Patent Application No. PCT/US2003/028295 mailed Dec. 21, 2004. US 8,771,763 B2 1. 2 COMPOSITION FORTREATING AIDS AND interpreted, and highly specific. Other manifestations of ASSOCATED CONDITIONS HTLV-II/LAV infections than those currently proposed to be reported are less specific and less likely to be consistently CROSS REFERENCE TO RELATED reported nationally. Milder disease associated with HTLV-III/ APPLICATIONS LAV infections and asymptomatic infections may be report able in some states and cities but will not be nationally report The present application is a Divisional of U.S. patent appli able. Because persons with less specific or milder cation Ser. No. 12/828,956, filed Jul. 1, 2010, now aban manifestations of HTLV-III/LAV infection may be important doned, which is a Continuation of U.S. patent application Ser. in transmitting the virus, estimates of the number of Such No. 10/902,993, filed Jul 30, 2004, now U.S. Pat. No. 7,749, 10 persons are of value. These estimates can be obtained through 544, issued Jul. 6, 2010, which is a Continuation of U.S. epidemiologic studies or special Surveys in specific popula patent application Ser. No. 10/241,973, filed Sep. 12, 2002, tions. now abandoned; all of the foregoing applications are incor Issues related to the case definition of AIDS were discussed porated herein by reference in their entireties. by the Conference of State and Territorial Epidemiologists 15 (CSTE) at its annual meeting in Madison, Wis., Jun. 2-5. BACKGROUND OF THE INVENTION 1985. The CSTE approved the following resolutions: 1. that the case definition of AIDS used for national report 1. Field of the Invention ing continue to include only the more severe manifestations This invention relates to a composition for treating AIDS of HTLV-III/LAV infection; and and related conditions, and more particular, to a composition 2. that the Center For Disease Control (CDC) develop more comprising at least one extract of a selected plant. inclusive definitions and classifications of HTLV-III/LAV 2. Description of the Prior Art infection for diagnosis, treatment, and prevention, as well as Patients with illnesses that, in retrospect, were manifesta for epidemiologic Studies and special Surveys; and tions of acquired immunodeficiency syndrome (AIDS) were 3. that the following refinements be adopted in the case first described in the summer of 1981 CDC Pneumocystis 25 definition of AIDS used for national reporting: pneumonia Los Angeles. MMWR 1981, 30:250-2; CDC - a. In the absence of the opportunistic diseases required by Kaposi's sarcoma and Pneumocystis pneumonia among the current case definition, any of the following diseases homosexual men New York City and California. MMWR will be considered indicative of AIDS if the patient has a 1981, 30:305-8. A case definition of AIDS for national positive serologic or virologic test for HTLV-III/LAV: reporting was first published in the MMWR in September 30 1. disseminated histoplasmosis (not confined to lungs or 1982 CDC Hepatitis B virus vaccine safety: report of an lymph nodes), diagnosed by culture, histology, or antigen inter-agency group MMWR 1982, 31:465-67: CDC Up detection; date on acquired immune deficiency syndrome (AIDS)— 2. isosporiasis, causing chronic diarrhea (over 1 month), United States. MMWR 1982, 31:507-14. Since then the diagnosed by histology or stool microscopy; definition has undergone minor revisions in the list of dis 35 3. bronchial or pulmonary candidiasis, diagnosed by eases used as indicators of underlying cellular immunodefi microscopy or by presence of characteristic white plaques ciency Jaffe HW.
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