Regulation of Apoptosis Pathway

TNF, FasL, TRAIL TNF, FasL, TRAIL Trophic Factors FADD c-IAP TRADD RIP

TRAF2 FADD Itch

TRADD PKC c-IAP

RIP1 TRAF2 CYLD ASK1 Cytoplasm PI3K RIP RAIDD FLIP PIDD p90RSK Erk1/2 Cell Cycle TAK1 Casp-2 NIK p53 JNK Bcl-2 Bad cdc2 IKKα IKKβ TRADD IKKγ FADD Casp-8, SirT2 -10 Bak RIP 14-3-3 Akt Bax TRAF2 Bcl-xL BID Cellular Stress FoxO1 I B к α Bim tBID NF-кB JNK Puma IкBα HtrA2 Mcl-1 HECTH9 NF-кB Arts Endo G Casp-12 AIF Cyto c Smac/ XIAP Calpain Casp-9 Diablo

Casp-3, Casp-9 [Ca2+] -6,-7 Apaf-1

DFF45 DFF40 Chk1/2 APP

ROCK ATM/ATR p53 ER Stress

- Cell shrinking - Membrane blebbing Cytoplasm

DFF40 Endo G Nucleus AIF p53 FoxO1 JNK

FLIP Puma Bim XIAP Noxa NF-кB DNA Fragmentation DNA Damage p53 c-Jun

Activation Separation of Subunits

Inhibition Joining of Subunits Multistep Activation Translocation antibody and ELISA experts Multistep Inhibition Transcriptional Activation Tentative Activation Transcriptional Inhibition For more pathways, please visit: www.bosterbio.com/pathway-maps Tentative Inhibition Key Products for Regulation of Apoptosis Visit www.bosterbio.com for full listing of antibodies, related kits, and reagents

ANTIBODIES APPLICATION REACTIVITY A01127 Anti-14-3-3 sigma/SFN Picoband™ Antibody ELISA, FC, IF, IHC, ICC, WB Human, Mouse, Rat A01141-1 Anti-14-3-3 zeta/delta/YWHAZ Picoband™ Antibody FC, IF, IHC-P, IHC-F, ICC, WB Human, Mouse, Rat M01571-1 Anti-AIF Picoband™ Antibody (monoclonal, 2I5) FC, IF, IHC-P, WB Human, Mouse, Rat PB9366 Anti-AIF/AIFM1 Picoband™ Antibody FC, IHC-P, IHC-F, ICC, WB Human, Mouse, Rat A00024 Anti-AKT1 Picoband™ Antibody WB Mouse, Rat A00040-1 Anti-Bcl-2/BCL2 Picoband™ Antibody FC, IHC, ICC, WB Human, Mouse, Rat A00181 Anti-Bcl-XL/BCL2L1 Picoband™ Antibody FC, IHC, ICC, WB Human, Mouse, Rat PB9027 Anti-Bid Picoband™ Antibody FC, IHC, ICC, WB Human, Mouse, Rat PA1364 Anti-Calpain 1/CAPN1 Antibody IHC, ICC, WB Human, Mouse, Rat A02384-1 Anti-Caspase-2/CASP2 Picoband™ Antibody ELISA, IHC, WB Human, Mouse, Rat PB9188 Anti-Caspase-3/CASP3 Picoband™ Antibody FC, IF, IHC-P, ICC, WB Human, Mouse, Rat PA1441-1 Anti-Caspase-6(P18)/CASP6 Antibody IHC, WB Mouse, Rat A02631 Anti-Caspase-6/CASP6 Picoband™ Antibody WB Human, Mouse, Rat PA1442 Anti-Caspase-7(P11)/CASP7 Antibody IHC, WB Human, Mouse, Rat PB9369 Anti-Caspase-7/CASP7 Picoband™ Antibody IHC, WB Human, Rat A00042-1 Anti-Caspase 8/CASP8 Picoband™ Antibody ELISA, WB Human, Mouse, Rat PA1524 Anti-Caspase-8(P10)/CASP8 Antibody IHC, WB Human PA1735 Anti-Caspase-8(p18)/CASP8 Antibody IHC, WB Human PB9332 Anti-Caspase-9/CASP9 Picoband™ Antibody WB Human PA1513 Anti-Caspase-10/CASP10 Antibody IHC, WB Human PA2103 Anti-Caspase-12/CASP12 Antibody IHC, WB Human M03529-5 Anti-Cytochrome C Picoband™ Antibody (monoclonal, 15F10) FC, IHC, ICC, WB Human, Mouse, Rat PB9334 Anti-Cytochrome C/CYCS Picoband™ Antibody IF, IHC-P, ICC, WB Human, Mouse, Rat PA1464 Anti-FADD Antibody WB Human PB9195 Anti-FOXO1A Picoband™ Antibody WB Human, Rat PB9110 Anti-IKK alpha/CHUK Picoband™ Antibody IHC, WB Human, Mouse, Rat PB9221 Anti-IKK beta/IKBKB Picoband™ Antibody IHC, WB Human A00874 Anti-IKK gamma/IKBKG Picoband™ Antibody FC, WB Human, Mouse, Rat PB9132 Anti-MCL1 Picoband™ Antibody IHC, WB Human, Mouse, Rat A00284-1 Anti-NF-κB p65/RELA Picoband™ Antibody ELISA, IHC, WB Human, Mouse, Rat PA1946 Anti-NFκB p100/p52/NFKB2 Antibody IHC, WB Mouse, Rat PB9149 Anti-NFκB p105/p50/NFKB1 Picoband™ Antibody IHC, WB Human, Rat PB9116 Anti-RIP/RIPK1 Picoband™ Antibody WB Human PB9860 Anti-Smac/Diablo Picoband™ Antibody ELISA, IHC, WB Human, Mouse, Rat PB10006 Anti-TAK1/MAP3K7 Picoband™ Antibody WB Human, Mouse, Rat PB9965 Anti-XIAP Picoband™ Antibody WB Human, Mouse, Rat

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