DOCSLIB.ORG

Microbiology-Today-November-2019

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Microbiology-Today-November-2019 University of Southern Denmark Antimicrobial resistance, antimicrobial peptides and drug repurposing Vorup-Jensen, Thomas; Hill Christiansen, Stig; Petersen, Jørgen Eskild Published in: Microbiology Today Publication date: 2019 Document version: Final published version Citation for pulished version (APA): Vorup-Jensen, T., Hill Christiansen, S., & Petersen, J. E. (2019). Antimicrobial resistance, antimicrobial peptides and drug repurposing. Microbiology Today, 46(4), 174-177. Go to publication entry in University of Southern Denmark's Research Portal Terms of use This work is brought to you by the University of Southern Denmark. Unless otherwise specified it has been shared according to the terms for self-archiving. If no other license is stated, these terms apply: • You may download this work for personal use only. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying this open access version If you believe that this document breaches copyright please contact us providing details and we will investigate your claim. Please direct all enquiries to [email protected] Download date: 11. Oct. 2021 Microbiology ANNUAL CONFERENCE TODAY Microbiology 46:4 Today November 2019 2020 46:4 November 2019 Natural Products and Drug Discovery Natural Products Monday 30 March to Friday 3 April 2020 and Drug Discovery EICC Edinburgh,UK Abstracts now open Actinomycetes as nature’s pharmacists Breaking barriers with garlic microbiologysociety.org/annualconference Manuka honey: potential from beehive to bedside #Microbio20 Burkholderia bacteria: natural alternatives to synthetic pesticides Antimicrobial resistance, antimicrobial peptides and drug repurposing MS Annual Conf ad 2020_03102019.indd 1 03/10/2019 10:27 ACCESS EARLY CAREER MICROBIOLOGISTS’ MICROBIOLOGY FORUM SUMMER CONFERENCE 2020 A new open access journal publishing University of Strathclyde, Glasgow, UK a variety of high-quality research 25–26 June 2020 outputs across the full spectrum of microscopic life forms. Cross-disciplinary scientifi c sessions Submit your article now featuring research from forum members microbiologyresearch.org Professional development training, including insights into what to do after your degree The opportunity to present your research and win poster prizes @MicrobioSoc #AccessMicro Stay connected and join our LinkedIn group @MicrobioSoc #ECMConf20 ACCESS MICROBIOLOGY_A4 ADVERT_03102019.indd 1 microb.io/ecmforumlinkedin03/10/2019 10:22 ECM SUMMER 2020_v2_A4_14102019.indd 6 15/10/2019 08:12 Editorial Welcome to the November edition of Microbiology Today, the last one for 2019! This time we are addressing the wonderful world of drug discovery and natural products. The natural world has provided us with a huge diversity of products, which have been utilised for everything from medicine to pesticides. The sources of the natural products can themselves be from a variety of places and include products produced by micro-organisms, plants and animals. Whole Picture he discovery of a novel molecule and the business involved in natural While prospecting around the is often the very first step in product design, Heather suggests globe in the hunt for natural products, Ta long process, leading to a how research in this field could move we sometimes forget to take a closer functional product that we then see in forward. look at what we already have. Thomas wider circulation. Our authors provide an On to a substance that needs input Vorup-Jensen, Stig Hill Christiansen insight into some of the current research from both plants and animals, Aled and J. Eskild Petersen look at how that is advancing natural products for Roberts discusses the role for honey in drug repurposing can create useful microbiology. infectious disease control, highlighting antimicrobial agents. Addressing First to take us into the world how variation between different honeys delivery, toxicity and development of natural products is Lorena affects their antimicrobial activity. costs, they demonstrate how rational Fernández-Martínez, who brings us Drawing on research which elucidates experimental design can uncover the actinomycetes. Highlighting the how manuka honey can inhibit bacteria effective antimicrobial candidates from role these micro-organisms have had in different ways, Aled addresses how compounds originally designed to treat over the years, she gives us a real this natural product could be used non-infectious diseases. appreciation of the impact these bacteria to help in the fight against antibiotic Finally, with the business end of have had in antimicrobial compound resistance. drug discovery in mind, Michael Bagnall development. Describing the diversity Next, we shift our focus from gives us the inside track on the various of products that have come from these medical to environmental, with Alex J. issues which can impact drug discovery micro-organisms, Lorena discusses Mullins and Eshwar Mahenthiralingam and natural product development from a how new culture approaches might lead explaining how Burkholderia have manufacturing point of view. Reminding to the discovery of previously hidden shown potential as natural alternatives us that discovering a promising natural compounds. to synthetic pesticides. With a growing product is only the very start of the It is not just micro-organisms world population that needs feeding, the process, Michael outlines the complex which can produce compounds with need for safe and effective pesticides and ever-evolving factors which need antimicrobial activity, and taking us from to protect food crops is becoming ever to be considered before a product can micro-organisms to plants, Heather Graz more important. Alex and Eshwar reach its intended market. gives us some insight into the research discuss the genomics which have led and development steps necessary to to the identification of key genes in Rowena Jenkins turn something like the humble bulb of these bacteria, and also the challenges Editor garlic into a registered pharmaceutical involved when designing a product that [email protected] product. Addressing both the science will be released into the environment. Microbiology Today Nov 19 | microbiologysociety.org 149 Contents Microbiology TODAY Articles Actinomycetes as nature’s pharmacists 158 Lorena T. Fernández-Martínez The diversity of novel bioactive compounds to be explored in actinomycetes. Breaking barriers with garlic 162 Heather Graz The medicinal potential of garlic. Manuka honey: potential from beehive 166 to bedside Aled Roberts The role of honey in infectious disease control. Burkholderia bacteria: natural alternatives 170 to synthetic pesticides Alex J. Mullins and Eshwar Mahenthiralingam The benefits and challenges involved in the use of bacteria as pesticides. Antimicrobial resistance, antimicrobial 174 peptides and drug repurposing Thomas Vorup-Jensen, Stig Hill Christiansen and J. Eskild Petersen Discovery of antimicrobial candidates from existing treatments. 46:4 November 2019 Features Regulars 157 Gill Elliott: Chair of the Virology Division 149 Editorial Find out more about the Virology Division Chair, Gill Elliott. 152 Council 2019 182 Annual General Meeting and Showcase of 153 From the President the Society’s Achievements Highlights from September’s event. 154 From the Chief Executive 183 Spotlight on grants 155 News Sabastine Arthur made use of our Education and Outreach Grant. 178 Annual Conference 2020 184 The new face of Microbiology 180 Focused Meetings 2019 Find out about the journal’s revised scope. 194 Reviews 186 Reviving the antibiotic research and Editor Rowena Jenkins development pipeline: marine natural Managing Editor Ruth Paget products Production Editor Ellen Hinkley The underwater search for antibiotics. Editorial Board André Antunes, Nigel Brown, David Blackbourn, Rachel Exley, 188 Reflections on being a member of the Lorena Fernández-Martínez, Rebecca Hall, Freya Harrison, Chloe James, Chris Randall, Nicola Stonehouse Microbiology Society Address Microbiology Society, 14–16 Meredith Street, London EC1R 0AB Hear from members about the benefits of being part of the Society. T +44 (0)20 3034 4870 E [email protected] 190 Microbiology Society and MiSAC: Design Ian Atherton, Corbicula Design (www.corbiculadesign.co.uk) Printed by Charlesworth Press, Wakefield 50 years of mutualism © 2019 Microbiology Society A look back at the relationship between the Microbiology Society and MiSAC. ISSN 1464-0570 191 ECM Forum update: Looking forward: The views expressed by contributors do not necessarily reflect official policy of the Society; nor can the claims of advertisers be guaranteed. translating research and tackling mental health Q&A with incoming Communications Representative, Robert Will. FSC Logo 192 Member Q&A Zina Alfahl tells us about her career. 193 Obituary Professor Michael Rossmann 1930–2019. 195 Comment – Industry insights in drug development Pharmaceutical research, Michael Bagnall conceptual image. Tek Image/ The drug development process at Merck Sharp & Dohme (MSD). Science Photo Library Council 2019 Executive Officers President – Professor Judith Armitage Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU; [email protected] General Secretary – Professor Maggie Smith Department of Biology, Wentworth Way, University of York, York YO10 5DD; [email protected] Treasurer – Professor Ian Roberts School of Biological Sciences, Faculty
Load more

Recommended publications
  • Annual Conference Abstracts
    ANNUAL CONFERENCE 14-17 April 2014 Arena and Convention Centre, Liverpool ABSTRACTS SGM ANNUAL CONFERENCE APRIL 2014 ABSTRACTS (LI00Mo1210) – SGM Prize Medal Lecture (LI00Tu1210) – Marjory Stephenson Climate Change, Oceans, and Infectious Disease Prize Lecture Dr. Rita R. Colwell Understanding the basis of antibiotic resistance University of Maryland, College Park, MD, USA as a platform for early drug discovery During the mid-1980s, satellite sensors were developed to monitor Laura JV Piddock land and oceans for purposes of understanding climate, weather, School of Immunity & Infection and Institute of Microbiology and and vegetation distribution and seasonal variations. Subsequently Infection, University of Birmingham, UK inter-relationships of the environment and infectious diseases Antibiotic resistant bacteria are one of the greatest threats to human were investigated, both qualitatively and quantitatively, with health. Resistance can be mediated by numerous mechanisms documentation of the seasonality of diseases, notably malaria including mutations conferring changes to the genes encoding the and cholera by epidemiologists. The new research revealed a very target proteins as well as RND efflux pumps, which confer innate close interaction of the environment and many other infectious multi-drug resistance (MDR) to bacteria. The production of efflux diseases. With satellite sensors, these relationships were pumps can be increased, usually due to mutations in regulatory quantified and comparatively analyzed. More recent studies of genes, and this confers resistance to antibiotics that are often used epidemic diseases have provided models, both retrospective and to treat infections by Gram negative bacteria. RND MDR efflux prospective, for understanding and predicting disease epidemics, systems not only confer antibiotic resistance, but altered expression notably vector borne diseases.
    [Show full text]
  • Holding Hands with Bacteria the Life and Work of Marjory Stephenson
    SPRINGER BRIEFS IN MOLECULAR SCIENCE HISTORY OF CHEMISTRY Soňa Štrbáňová Holding Hands with Bacteria The Life and Work of Marjory Stephenson 123 SpringerBriefs in Molecular Science History of Chemistry Series editor Seth C. Rasmussen, Fargo, North Dakota, USA More information about this series at http://www.springer.com/series/10127 Soňa Štrbáňová Holding Hands with Bacteria The Life and Work of Marjory Stephenson 1 3 Soňa Štrbáňová Academy of Sciences of the Czech Republic Prague Czech Republic ISSN 2191-5407 ISSN 2191-5415 (electronic) SpringerBriefs in Molecular Science ISSN 2212-991X SpringerBriefs in History of Chemistry ISBN 978-3-662-49734-0 ISBN 978-3-662-49736-4 (eBook) DOI 10.1007/978-3-662-49736-4 Library of Congress Control Number: 2016934952 © The Author(s) 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication.
    [Show full text]
  • Microbiology Society Activities
    MICROBIOLOGY TODAY 48:1 May 2021 Microbiology Today 48:1 May 2021 Life on a Changing Planet Life on a Changing Planet Exploring the relationship between climate change and the microbial world Forest Fire in Dixie National Forest, Utah, USA. santirf/iStock which in turn increase the risk of COVID-19 complications. impact on respiratory health of affected communities. Curr Opin Pulm Wildfire smoke exposure might also increase the likelihood of Med 2019;25:179–187. comorbidities, including cardiovascular diseases, respiratory Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. Air pollution and diseases, diabetes and hypertension, leading to an increased COVID-19 mortality in the United States: strengths and limitations of an ecological regression analysis. Sci Adv 2020;6:eabd4049. COVID-19 risk. Higher daily average PM2.5 concentrations during the wildfire season in western US states were positively Gosling SN, Bryce EK, Dixon PG, Gabriel KMA, Gosling EY et al. associated with increased influenza rates the following A glossary for biometeorology. Int J Biometeorol 2014;58:277–308. winter, indicating strong evidence for delayed effects of wildfire exposure. Research on understanding the underlying mechanisms between wildfire exposure and respiratory Rosa von Borries infection is an area of active investigation. Consultant at World Meteorological Organization, In particular, vulnerable population groups such as socio- Bernhard-Lichtenberg-Str 15, 10407 Berlin, economically disadvantaged populations, individuals with Germany comorbidities and the elderly face higher risks of experiencing [email protected] the combined consequences of COVID-19 and wildfires. @rosavborries In the US, migrant farmworkers who were continuously linkedin.com/in/rosa-von-borries-5b4987197 exposed to wildfire smoke and deemed essential workers during the pandemic faced much higher risks of severe Rosa von Borries holds an MSc in Public Health from London School health consequences from wildfire smoke and COVID-19.
    [Show full text]
  • Qumrter{Y Rn{-}#R.}Rin* Nf Thw S**:Imty Rnicrr:Hl*I*E5r
    F r-nierobiologytodcly i W; vol33i oug06 ,: qumrter{y rn{-}#r.}rin*nf thw s**:imty f'*r 6*[":*l"C*l rnicrr:hl*i*E5r I f vcl33(3) [*j'l-l l.-ili:i i" t'.ir'iliL.i i{:}li 90 News 128 Cradline 134 Reviews 122 Meetings 130 Hotoff the press 139 Addresses 124 Schoolzone132 Coingpublic it'l i:)'i-:il;I i i i::ji-i-l:; 117 Usingmicroscopy to enhanceundergraduate teaching 127 Letter 136 obituaries i:l l'Tl{,-li:}S 96 Fluorescencemicroscopy Canyou seethe asa researchtool in bacterial light? cellbiology lain Hagan , AgnesCrallert & Jeff Errington SteveBagley The revolution of new views of the subcellularorganization Simpleand affordable steps to exploitrecent of bacteria. advancesin ffuorescenceimaging. 100 |nvestigating a bacterial killer usingatomic force microscopy 118 HenryBaker: author of the MeganNufiez & EileenSpain first m icroscopy labo ratory Learnabout the secretlife of the predatorykiller, Bdellovibrio. manual Virusesand intracellular RichardBurns This18th century polymath played a big partin popularizing movement earlymicroscopes. TomWileman How do virusesmanaSe to move within and between the cellsof their host? Comment - Openoption for SCM 108 Studyingsingle molecules in journals microbialsystems RonFraser & RobinDunford ChristophBaumann Openaccess demands by grant-awardingbodies Individualmolecules in livingcells can now be observed. arecausing problems for publishers. {ovr:r inoge Microscopelenses. Tony Craddock / SciencePhoto Library Theviews expressed fditr.rrDrCavinThomas[lcii|*riili{l*"lrdDr5ueAssinder'Professor|ainHagan,ProfessorBertRlma
    [Show full text]
  • 70Th Anniversary Collection of the Microbiology Society: Journal of General Virology Robin A
    Journal of General Virology (2015), 00, 1–3 DOI 10.1099/jgv.0.000286 Commentary 70th Anniversary Collection of the Microbiology Society: Journal of General Virology Robin A. Weiss Correspondence Division of Infection & Immunity, University College London, London WC1E 6BT, UK Robin A. Weiss [email protected] To mark the 70th anniversary of the founding of the Society From its inception, the Journal of General Virology took for General Microbiology (now renamed the Microbiology papers on the structure and design of virus particles, Society) it was decided to showcase 70 salient publications such as human adenovirus type 5. In a superb biochemical from the archives of its various journals. The Journal of Gen- and structural analysis comprising three consecutive eral Virology was allocated 15 papers. I was invited to curate papers, the second paper by Russell et al. (1967) showed them and given a carte blanche which ones to choose. True that when heated to 56 8C, the icosahedral capsid ruptured to the name of the journal, I picked a broad range of viruses at the penton bases and liberated viral DNA. They also cor- and a paper on prion disease. If readers are disappointed not rectly predicted that unknown nucleocore proteins exist to see their own most cherished contribution featured that in later years became important for understanding among them, please consider the odds: only 15 from over cell transformation and early steps in virus replication. 15 000 Journal of General Virology articles could be selected The only paper among the 15 selected that does not present and I gave more weight to older papers to recall contri- primary research data is the commentary on virus diversity butions by the pioneers of virology.
    [Show full text]
  • Microbiologytoday Biology and Pathogenesis Current Technology and Author: Naveed Khan Molecular Biology Applications
    Caister Academic Press New Books for 2009 www.caister.com Acanthamoeba Lactobacillus Real-Time PCR microbiologytoday Biology and Pathogenesis Current Technology and Author: Naveed Khan Molecular Biology Applications ... available now! c. 220 pp., February 2009 From Genomics to Probiotics Edited by: J. Logan, K. Edwards and N. Saunders ISBN: 978-1-904455-43-1 $310 / £150 Edited by: Åsa Ljungh and Torkel Wadström x + 284 pp., January 2009 The first comprehensive review of c. 220 pp., January 2009 ISBN 978-1-904455-39-4 $310 / £150 Acanthamoeba research to be published. ISBN 978-1-904455-41-7 $310 / £150 A comprehensive guide to the latest PCR The current state of research on every aspect An essential reference for all dairy of this organism, detailing major advances platforms, fluorescent chemistries, validation technologists, microbiologists and in areas such as genomics, molecular and software, data analysis, internal and external cellular biology, life cycles, geographical biotechnologists. Includes phylogenetics, controls and a wide range of applications: distribution, role in ecosystem, morphology, taxonomy, comparative genomics, functional clinical diagnostics, biodefense, RNA vol35|nov08 genomics, the intestinal microflora, surface motility, phylogenetics, genotyping, metabolism, expression studies, validation of array data, quarterly regulation of morphogenesis, host-parasite proteins, stress responses, interaction with mutation detection, food authenticity and interactions, the molecular and immunological the immune system, probiotics, anti-cancer legislation, NASBA, and molecular halotyping. basis of pathogenesis, methods of transmission, potential, and much more. Essential reading for magazine of epidemiology, clinical manifestation, diagnosis, all scientists involved with lactic acid bacteria treatment, new target development and drug or probiotic research and a recommended book the society resistance.
    [Show full text]
  • Downloaded from the SGM Website
    F I: t' SGMHeadquarterc MarlborouqhHouse. Articles Basingsto[eRoad, Spencers Thingsthat go rotin the night - Wood,Reading RG7 lAG Tel.01 18 988 1800 a reviewof biodeteriorationGlyn Morton 103 Fax01 189885656 [email protected] Everythingyou wanted to knowaboutthe dry-rot SGMWebsite fungusbutwere afraid to askJohnW Palfreyman http:./www.sgm.ac.uk &NiaA.White 107 Editor Lichens,agents of monumentaldestruction DrMerielJones MarkR.D.Seaward 110 EditorialBoard ProfessorDave Kelly Conservationof monu m ental stones bv bacterial ProfessorTonyNash biomineralizationBrunetla Perito &Giorgio Mastromei 1 13 ManagingEditor JanetHurst Sulfate-red uci n g bacteriain biofiI ms on metalIic Production Editor materialsand corrosion lwonaB. Beech 11 5 lanAtherton AssistantEditorand TheBiodeterioration Centre, University of Herbfordshire BookReviewManager RichardSmith 1 18 JaniceMeekings Pilzkrieg :the German warti me quest for penicil lin Gontributions Theseare always welcome and GilbertShama 120 shouldbe addressed tothe Editor AcuteRespi ratory rome(SARS) (c/o SGM Headquarters), Severe Synd FaveJones 124 CopyDates Lastdates for receipt of copy atMarlborouqh House are aeneratuopv Regular Featunes November2003 issue 1 Sept Februarv2004 issue 8 December MicroShorts 117&141 AOVerUSemen$ (LKl-.l November2003 issue 29 Sept SocietyNews February2004 issue1 9 January MayCouncilMeeting 126 Advertisements Above:Ascanning usuallycaused bysulfate- NewsofMembers 126 (SRB) Allenquiriesshould be sentto: electronmicrograph of the reducingbacteria and StaffNews 126 Domin
    [Show full text]
  • Microbiologytoday
    microbiologytoday microbiology vol36|feb09 quarterly magazine of the society today for general microbiology vol 36 | feb 09 the legacy of fleming ‘that’s funny!’: the discovery of penicillin what manner of man was fleming? the future of antibiotic discovery look who’s talking when good bugs fight bad contents vol36(1) regular features 2 News 38 Schoolzone 46 Hot off the Press 10 Microshorts 42 Gradline 49 Going Public 36 Conferences 45 Addresses 60 Reviews other items 33 The Defra-commissioned independent review of bovine tuberculosis research 54 Education Development Fund report 58 Obituary – Professor Sir James Baddiley FRS 59 Obituary – Emeritus Professor Naomi Datta FRS articles 12 ‘That’s funny!’: the 24 Look who’s talking! discovery and development Julian Davies of penicillin Antibiotics aren’t just for fighting infections; they are part of the bacterial signalling network. Kevin Brown The chance discovery of penicillin 80 years ago made Alexander Fleming a famous scientist. 28 When good bugs fight bad Roy Sleator 16 What manner of man was There are alternative methods available Alexander Fleming? for combating infectious diseases – not just antimicrobial chemotherapy. Philip Mortimer Alexander Fleming, the Society’s first President, did so much more than discover penicillin. 32 A precious memory Norberto Palleroni One of the few people left who met Fleming recounts his 20 Antibiotics and experience. Streptomyces: the future of antibiotic discovery 64 Comment: Debating creationism Flavia Marinelli Many options for drug discovery
    [Show full text]
  • Microbiology Society
    MICROBIOLOGY TODAY 47:1 May 2020 Microbiology Today May 2020 47:1 Why Microbiology Matters – 75th anniversary issue Why Microbiology Matters We are celebrating our 75th anniversary by showcasing why microbiology matters and the impact of microbiologists past, present and future. MICROBIOLOGY TODAY 47:1 May 2020 Microbiology Today May 2020 47:1 Why Microbiology Matters – 75th anniversary issue Why Microbiology Matters We are celebrating our 75th anniversary by showcasing why microbiology matters and the impact of microbiologists past, present and future. Editorial Welcome to Microbiology Today, which has a new look. This issue is the first of two special editions of the magazine to be published in the 75th anniversary year of the Microbiology Society. As we look back and celebrate during 2020, we are also considering ‘Why Microbiology Matters’. The longer you think about it, the more you realise how in so many ways it does. Whole Picture ince the first observations of microbes by Antonie van thrive in extreme conditions and are found in every niche Leeuwenhoek in the 1600s, our understanding of how around the globe. Smicrobes underpin and impact our lives has advanced Part of the reason for the success of microbes in these considerably. From discovering their life cycles and roles within varied environments is their genetic plasticity. Charles Dorman various environmental niches to harnessing them in industrial introduces the next section on microbial genetics and the role processes, and, not least, our ability to utilise them for good, to it has played in advancing modern biotechnology. From the vaccinate and treat diseases, with many diseases now known original discovery of restriction enzymes through to potential to be caused by microbes.
    [Show full text]
  • Downloadedfrom the SGM Invertebrates), Consideri Ng Involvement in Microbiology, the Nu M Ber of Staffand Applicationforms for These
    SGMHeadquarters MarlboroughHouse, Articles BasingstokeRoad, Spencers Wood,Reading RG7 l AG Clinicalmicrobiology:a new golden age? Tel. 011BgBB1800 StephenGillespie Fax 01 189885656 Whatmakes a pathogen? emailmtoday@sg m.ac.uk C,Anthony Hart & CraigWinstanley SGMWebsite http:./wwwsgm.ac.uk Theenemy within - hospital-acquired, antibiotic- Editor resistantbacteria Peter Hawkey Dr MerielJones Fungalinfections in the immunocompromised EditorialBoard MarcMendelson ProfessorDave Kelly 10 Dr LynneMacaskie Theuse of moleculartechniquesto detect antimicrobial ManagingEditor resistanceinclinical bacterial isolates Janet Hurst Ad C,Fluit&Franz-Josef Schmib. 1At+ Produc{ion Editor lanAtherton Howtechnology drives pathogen d iscovery PauI Kellam& Robin Assistant Editor and A, Weiss to Book Review Manager {n Microbiology before Pasteur M i lto n Wai n w ri g ht It, JaniceMeekings parasites - Gontributions Protozoan inthe UK causefor concern? These are alwayswelcome and TimMcHugh oo shouldbe addressedto the Editor (c/o SGM Headquarters). GopyDates Last dates for receiptof copy Regular Features at MarlborouohHouse are: SocietyNews oeneral uoDV Mav2001issue2Aoril November Counci IMeeting 24 August2O0l issue29 May Nominationsfor Members of Council 24 Advertisements (CRC) Above:The risein (pp.1 - 15) describe how NewYearsHonours 24 May2001 issue30April OA hospital-acouired i nfection. newmethods can speed up NewontheSGMwebsite z+ August200 1 issue 25 June Howserious is the ihreat to theirdetection, StaffNews OA Advertisements ourhealth care? NewGroup Conveners
    [Show full text]
  • Microbiology Society
    Advertisement Feature Research Grade Galleria mellonella Microbiology TruLarv™ Galleria mellonella are more cost effective than bait shop larvae TODAY Increased reproducibility G. mellonella have been commercially 44:2 May 2017 available as food for captive reptiles and Variability between the responses of individual larvae, Microbiology The 44:2 Microbiome Today May 2017 birds and as fishing bait, and these larvae and the variability between replicate experiments can have been widely used in research. Fishing mean that experiments using bait shop larvae need bait G. mellonella are cheap to buy so here to be repeated many times to obtain a meaningful we explain why TruLarv™ cost more, but result. Independent research has shown that replicate can save you money. experiments using TruLarv™ are significantly more reproducible than experiments using bait shop larvae. TruLarv™ contain no antimicrobials, hormones Increased Power or other chemicals Our decontaminated larvae consistently show no Prophylactic antibiotics and hormones are usually used deaths in control groups (n=10) injected with PBS, in the breeding of bait shop G. mellonella because they whereas in our comparative studies other groups markedly increase the colony yield. However, residues of larvae typically show at least one death. Deaths of these chemicals remain in the larvae affecting the in the control groups can significantly reduce the reproducibility and sensitivity of your experiments experimental power of your study, meaning that and making it difficult or impossible to interpret data. subtle differences cannot be detected. The additional TruLarv™ are bred from a separate colony maintained statistical power that TruLarv™ provide to your without antimicrobials, hormones or other chemicals.
    [Show full text]
  • Ouarterly Magaiine of the Society for General
    OUARTERLYMAGAIINE OFTHE SOCIETY FORGENERAL [/ICROBIOLOGY VOLUME 27NOVEMBER 2OOO Thenature of TSEs Viroids- thesmallest living fossils? Virusesrule the waves Astrobiology Transposableelements I Nan o bacte ria L Unculturables and bacterial diversity q ', i i l ffiI;ffiffi'ffi:ffiffi,% l SGM Headquarters MarlboroughHouse, Articles Basingstoke Road, Spencers Wood,Reading RG7 1AG Thetwilight zones of microbiologyJoh n Postgate 162 Tel 01189881800 Thenature of TSEsChris Bostock 164 FaxOl 189885656 emailmtoday@sgm,ac,u k Viroidsand othersub-viral pathogens of plants: SGMWebsite thesmallest living fossils? http:,/,/www.sg m.ac.u k NicolaSpence & DezBarbara 168 Editor Virusesrule - DrlVerielJones thewaves thesmallest and mosr abundantmembers of marineecosystems Editorial Board ProfessorDave Kelly GunnarBratbak&MikalHeldal 171 DrLynne lVacaskie Insearch of asecond evolutionaryexperiment ManagingEditor DonCowan & MonbaGrady 174 JanetHurst MobilegenesNrcholasWest&ChristophTang Production Editor 178 lanAtherton Nanobacteria:goldmine or minefield of intellectual Assistant Editor and enguiryAllan Hamrlton 182 Book Review Manager 'unculturable JaniceMeekings Bacterialdiversity and s'John Fry 1Bo Contributions Theseare always welcome and shouldbe addressed tothe Editor (c/oSG M Headquarters). Regular Features CopyDates SocietyNews I acl.letoc fnr'- roe--- oinl r"- n{ cr-rPY JulyCouncil Meeting 190 at l\,4arlboroughHouse are: NewMembers of Counciland Group Committees 190 General Copy NewHonoraryMembers February2O01issue 20 November 191 NewGroup Conveners
    [Show full text]