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Micro Biology 40:1 Feb 2013 MICRO BIOLOGY TODAYQuarterly Magazine of the Society for General Microbiology Viruses and cancer • HIV and immune suppression • Human papillomaviruses • Viral hepatitis and HCC • Vaccines for Epstein–BarrMicrobiology virus Today Feb 2013 1 22337_Chloramphenicol Ad_Micro Today_AW:1 11/4/12 17:10 Page 1 CHLORAMPHENICOL Widely distributed throughout the body, including CSF1 EDITORIAL Oral levels comparable to i.v. levels2 3 Rarely implicated with C.difficile Effective against serious infections including: H. influenzae1,2 Typhoid1,2 Welcome to the first issue of MRSA4 Microbiology Today of 2013, which will VRSA5 Neisseria1,2 be a year of great change for SGM. Legionella1,2 I will be finishing my tenure as Editor human papillomaviruses by Jo Parish 1,2 Rickettsia of Microbiology Today in September. & Sally Roberts. Robert Newton also 6-9 C.difficile The excellent Laura Bowater, a senior provides us with an excellent overview E. coli1 lecturer in the Medical School from the of the epidemiological burden of virus- University of East Anglia will succeed me associated cancers. in the post. I hope Laura will find the We have also included an post as enjoyable, stimulating and interview with Professor zur Hausen, Abbreviated Prescribing Information respiration and death within a few hours of the onset of symptoms. fun as I have – good luck! where he gives us a great insight into Chloramphenicol Capsules BP 250mg Overdose: Stop chloramphenicol immediately if signs of adverse events develop. Treatment is mainly supportive. If an allergy develops, This issue of Microbiology Today his work and career in virology. In all, it Presentation: Capsules containing 250mg chloramphenicol BP. oral antihistamines may be used. In severe overdosage e.g. Gray Baby Indications: Typhoid fever and life-threatening infections, particularly Syndrome, reduce plasma levels of chloramphenicol rapidly. Resin is a ‘virology special’; this is in part really is a tour de force of the area. those caused by Haemophilus Influenzae, where other antibiotics will haemoperfusion (XAD-4) has been reported to substantially increase not suffice. chloramphenicol clearance. to recognise the contribution of this The Comment in this issue is Posology: For oral administration. Pack size and Price: 60 capsules £377.00 year’s SGM Prize Medal winner, Harald provided by Leighton Chipperfield, Adults and elderly: 50mg/kg body weight daily in 4 divided doses. Legal Category: POM. For severe infections (meningitis, septicaemia), this dose may be Market Authorisation Number: PL17736/0075. zur Hausen, and his ground-breaking Head of Publications at SGM, where doubled initially, but must be reduced as soon as clinically possible. Market Authorisation Holder: Chemidex Pharma Limited, 7 Egham Children: Not recommended. Business Village, Crabtree Road, Egham, Surrey TW20 8RB, UK. contributions to understanding the link he outlines the challenges and Contra-indications: Known hypersensitivity or toxic reaction to Date of preparation: April 2012. chloramphenicol or to any of the excipients. Should not be used See Chloramphenicol Summary of Product Characteristics for full between viruses and cancer. The issue opportunities that lay ahead for SGM in for the prophylaxis or treatment of minor infections; during active prescribing information. immunisation; in porphyria patients; in patients taking drugs liable owes a huge debt to David Blackbourn, the changing landscape that is academic to depress bone marrow function; during pregnancy, labour or by breast-feeding mothers. Adverse events should be reported. Reporting forms and whose knowledge and expertise in this publishing. Special warnings and precautions for use: Use only if other treatments information can be found at www.mhra.gov.uk/yellowcard. area was invaluable in identifying and I hope you enjoy this issue of are ineffective. Use should be carefully monitored. Reduce dose and Adverse events should also be reported to Essential monitor plasma levels in hepatic or renal impairment in the elderly and Microbiology Today. in patients concurrently treated with interacting drugs. Generics on 01784 477167. inviting authors – in fact David did most Interactions: Chloramphenicol prolongs the elimination, increasing the of the author identification and arm- blood levels of drugs including warfarin, phenytoin, sulphonylureas, tolbutamide. Doses of anticonvulsants and anticoagulants may need to References twisting! We have relied heavily on the PAUL A. HOSKISSON, Editor be adjusted if given concurrently. Complex effects (increased/decreased 1. Sweetman S.C. (ed), Martindale: The Complete Drug Reference. plasma levels) requiring monitoring of chloramphenicol plasma levels [online] London: Pharmaceutical Press Viral Oncology group at the University Email [email protected] have been reported with co-administration of penicillins and rifampicin. <http://www.medicinescomplete.com/> (Accessed on 22 August 2011). Paracetamol prolongs chloramphenicol half-life. Chloramphenicol may 2. Feder, H. Chloramphenicol: What we have learned in the last Decade. 22337 of Birmingham, who have done a great increase the plasma levels of calcineurin inhibitors e.g. ciclosporin Southern Medical Journal. 1986; 79(9): 1129-34. 3. Kelly, C., LaMont, T. and tacrolimus. Barbiturates such as phenobarbitone increase Patient information: Antibiotic-associated diarrhea (Clostridium difficile). job. It has been a fascinating issue to the metabolism of chloramphenicol, resulting in reduced plasma www.uptodate.com. (Accessed on 11 August 2011). 4. Fluit, A.C., chloramphenicol concentrations. In addition, there may be a decrease Wielders, C.L.C., Verhoef, J., and Schmitz, F.J. Epidemiology and edit and I have learned a huge amount in the metabolism of phenobarbitone with concomitant chloramphenicol Susceptibility of 3,051 Staphylococcus aureus Isolates from 25 in this area. use. There is a small risk that chloramphenicol may reduce the University Hospitals Participating in the European SENTRY Study. contraceptive effect of oestrogens. Chloramphenicol reduces the Journal of Clinical Microbiology. 2001; 39(10): 3727-3732. 5. Weigel LM We begin with an overview of response to hydroxocobalamin. Chloramphenicol is contra-indicated et al. High-Level Vancomycin-Resistant Staphylococcus aureus (VRSA) in patients taking drugs liable to suppress bone marrow function Associated with a Polymicrobial Biofilm. Antimicrobial Agents and viruses and cancer by Laura Hindle & e.g. carbamazepine, sulphonamides, phenylbutazone, penicillamine, Chemotherapy. Published online ahead of print on 30 October 2006. cytotoxic agents, some antipsychotics including clozapine and http://aac.asm.org/cgi/reprint/AAC.00576-06v1.pdf. (Accessed on David Blackbourn, followed by several particularly depot antipsychotics, procainamide, nucleoside reverse 22 August 2011). 6. Ensminger, P., Counter, F., Thomas, L., Lebbehuse, transcriptase inhibitors, propylthiouracil. P. Susceptibility, Resistance Development, and Synergy of Antimicrobial articles covering more specific areas of Pregnancy and Lactation: The use of chloramphenicol is contra-indicated Combinations Against Clostridium difficile. Current Microbiology. Essential Generics: Chloramphenical Ad as the drug crosses the placenta and is excreted in breast milk. 1982; 7: 59-62. 7. Poilane, I., Bert, F., Cruaud, P., Nicolas-Chanoine, interest. These cover a range of viruses Effects on ability to drive and use machines: No significant effect MH., Collignon, A. Interest of the disk diffusion method for screening on driving ability. Clostridium difficile isolates with decreased susceptibility to antibiotics. and diseases such as viral hepatitis and Undesirable Effects: Reversible dose related bone marrow depression, PathologieBiologie (Paris). 2007; 55(8-9): 429-33. 8. Cattoir, V., hepatocarcinoma by Jane McKeating irreversible aplastic anaemia, increased bleeding time, hypersensitivity Ould-Hocine, ZF.,Legrand, P. Antimicrobial susceptibility of Clostridium reactions including allergic skin reactions, optic neuritis leading to difficile clinical isolates collected from 2001 to 2007 in a French CAPSULES & Colin Howard, Epstein–Barr virus blindness, ototoxicity, acidotic cardiovascular collapse, nausea, vomiting, university hospital. PathologieBiologie (Paris). 2008; 56(7-8): 407-11. glossitis, stomatitis, diarrhoea, enterocolitis, Gray Baby Syndrome 9. Brazier, JS., Levett, PN., Stannard, AJ., Phillips, KD., Willis, AT. mm Bleed: 3 mm Supply as hi-res PDF Job no: by James Turner & Graham Taylor and particularly in the newborn, which consists of abdominal distension, Antibiotic susceptibility of clinical isolates of clostridia. Journal of PIP: 106-5796 210 EG/CH/APR/2012/08 pallid cyanosis, vomiting, progressing to vasomotor collapse, irregular Antimicrobial Chemotherapy. 1985; 15(2): 181-5. x AAH: CHL600B 297 ALLIANCE: O65995 2 Microbiology Today Feb 2013 Microbiology Today Feb 2013 1 Trim size: Trim Journal: Microbiology Today Journal: Microbiology Today MOVIANTO: CHL25060 For further information, please contact: Essential Generics, 7 Egham Business Village, Crabtree Road, Egham, Surrey TW20 8RB, UK CONTENTS SGM Council 12/13 MICROBIOLOGY TODAY 40:1 Feb 2013 FEATURES WWW.SGM.AC.UK/PUBS/MICRO_TODAY 38 Schoolzone 44 How to Executive Officers James Redfern organise a President – Professor Nigel L. Brown describes a virus conference c/o Society for General Microbiology, Marlborough House, practical that can Karen McGregor ARTICLES Basingstoke Road,
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