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Annual Conference Abstracts
ANNUAL CONFERENCE 14-17 April 2014 Arena and Convention Centre, Liverpool ABSTRACTS SGM ANNUAL CONFERENCE APRIL 2014 ABSTRACTS (LI00Mo1210) – SGM Prize Medal Lecture (LI00Tu1210) – Marjory Stephenson Climate Change, Oceans, and Infectious Disease Prize Lecture Dr. Rita R. Colwell Understanding the basis of antibiotic resistance University of Maryland, College Park, MD, USA as a platform for early drug discovery During the mid-1980s, satellite sensors were developed to monitor Laura JV Piddock land and oceans for purposes of understanding climate, weather, School of Immunity & Infection and Institute of Microbiology and and vegetation distribution and seasonal variations. Subsequently Infection, University of Birmingham, UK inter-relationships of the environment and infectious diseases Antibiotic resistant bacteria are one of the greatest threats to human were investigated, both qualitatively and quantitatively, with health. Resistance can be mediated by numerous mechanisms documentation of the seasonality of diseases, notably malaria including mutations conferring changes to the genes encoding the and cholera by epidemiologists. The new research revealed a very target proteins as well as RND efflux pumps, which confer innate close interaction of the environment and many other infectious multi-drug resistance (MDR) to bacteria. The production of efflux diseases. With satellite sensors, these relationships were pumps can be increased, usually due to mutations in regulatory quantified and comparatively analyzed. More recent studies of genes, and this confers resistance to antibiotics that are often used epidemic diseases have provided models, both retrospective and to treat infections by Gram negative bacteria. RND MDR efflux prospective, for understanding and predicting disease epidemics, systems not only confer antibiotic resistance, but altered expression notably vector borne diseases. -
Future Science Group
future science group CATALOGUE 2014 www.future-science-group.com Contents Welcome 2 International Journal of Future Science Subject collections 4 Endocrine Oncology 30 Journals 43 Future Medicine International Journal of Bioanalysis 46 Hematologic Oncology 31 Journals 11 Clinical Investigation 47 Interventional Biomarkers in Medicine 14 Future Medicinal Chemistry 48 Cardiology 32 Breast Cancer Management 15 Pharmaceutical Journal of Comparative Clinical Lipidology 16 Bioprocessing 49 Effectiveness Research 33 Clinical Practice 17 Pharmaceutical Patent Lung Cancer Analyst 50 CNS Oncology 18 Management 34 Therapeutic Delivery 51 Colorectal Cancer 19 Melanoma eBooks Diabetes Management 20 Management 35 52 Publication Epigenomics 21 Nanomedicine 36 solutions 56 Future Cardiology 22 Neurodegenerative Post-publication Future Microbiology 23 Disease Management 37 solutions 58 Future Neurology 24 Pain Management 38 Information for Future Oncology 25 Personalized Medicine 39 authors 59 Future Virology 26 Pharmacogenomics 40 Information for Hepatic Oncology 27 Regenerative Medicine 41 librarians 60 Immunotherapy 28 Women’s Health 42 Trials information 61 International Journal of Clinical Rheumatology 29 Future Science Group – Catalogue 2014 Browse our products & services Subject collections 4–9 “Your Complete Digital Library” To help you pinpoint the most relevant titles for you, we have highlighted journals that fall within one of our subject collections: Oncology, Neurology, Cardiology, Immunology, Molecular Medicine and Drug R&D. Look for the subject collection tab on each journal page. Future Medicine Journals 11–42 “Tomorrow’s medicine today” 30 journals providing cutting-edge coverage of postgenomic medicine. Future Science Journals 43–51 “Revelations in R&D” High-quality commentary and analysis in today’s key areas of research endeavor. -
Table of Contents
Table of Contents Verbal Presentations Verbal Presentations – Monday………………………………………………………...................... Page 2 Verbal Presentations – Tuesday……………………………………………………………………… Page 17 Verbal Presentations – Wednesday………………………………………………………..…….….. Page 32 Verbal Presentations – Thursday……………………….……………………………….………..…. Page 46 Poster Presentations Poster Presentations – Monday…………………………………………………………………..…. Page 52 Poster Presentations – Tuesday……………………………………………………………..……… Page 64 Poster Presentations – Wednesday……………………………………………………….……….. Page 77 Poster Presentations – Thursday……………………………………….………………….……….. Page 90 Page 1 of 99 Verbal Presentations Monday, May 15th 8:30 – 10 AM Grumman A Microsimulation Approach to Estimating Annual Risk in QMRA. Coping with Non-Random Variation in Risk Amongst Populations Paul Hunter, The Norwich Medical School, University of East Anglia Additional Author: James Maas Most QMRA studies have focused on refining the estimation of the daily risk comparatively little thought has been given to estimating the annual risk. As pointed out by Karavarsamis and Hamilton most studies have used a relatively simple method of estimating annual risk from the distribution of daily risks, namely 1-(1-Pd)^365 (1). This approach essentially assumes that the daily risk is constant through the year and Karavarsamis and Hamilton, with justification, refer to this approach as "Naϊve". Instead they propose a stochastic approach that essentially samples the distribution of daily risks and then calculates the annual risk as 1-the product of (1- 365 randomly sampled daily risk), calling this the "Gold Standard Approach". We argue that Karavarsamis and Hamilton's gold standard approach is also naϊve. Daily risks in any one individual are neither constant through a year nor are they entirely random. For example, across a population some people drink a lot of water each day and others drink very little. Other factors like the concentration of pathogen in a supply may vary much more randomly. -
Extensive Microbial Diversity Within the Chicken Gut Microbiome Revealed by Metagenomics and Culture
Extensive microbial diversity within the chicken gut microbiome revealed by metagenomics and culture Rachel Gilroy1, Anuradha Ravi1, Maria Getino2, Isabella Pursley2, Daniel L. Horton2, Nabil-Fareed Alikhan1, Dave Baker1, Karim Gharbi3, Neil Hall3,4, Mick Watson5, Evelien M. Adriaenssens1, Ebenezer Foster-Nyarko1, Sheikh Jarju6, Arss Secka7, Martin Antonio6, Aharon Oren8, Roy R. Chaudhuri9, Roberto La Ragione2, Falk Hildebrand1,3 and Mark J. Pallen1,2,4 1 Quadram Institute Bioscience, Norwich, UK 2 School of Veterinary Medicine, University of Surrey, Guildford, UK 3 Earlham Institute, Norwich Research Park, Norwich, UK 4 University of East Anglia, Norwich, UK 5 Roslin Institute, University of Edinburgh, Edinburgh, UK 6 Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Banjul, The Gambia 7 West Africa Livestock Innovation Centre, Banjul, The Gambia 8 Department of Plant and Environmental Sciences, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus, Hebrew University of Jerusalem, Jerusalem, Israel 9 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK ABSTRACT Background: The chicken is the most abundant food animal in the world. However, despite its importance, the chicken gut microbiome remains largely undefined. Here, we exploit culture-independent and culture-dependent approaches to reveal extensive taxonomic diversity within this complex microbial community. Results: We performed metagenomic sequencing of fifty chicken faecal samples from Submitted 4 December 2020 two breeds and analysed these, alongside all (n = 582) relevant publicly available Accepted 22 January 2021 chicken metagenomes, to cluster over 20 million non-redundant genes and to Published 6 April 2021 construct over 5,500 metagenome-assembled bacterial genomes. -
1985517720.Pdf
JOURNAL OF BACTERIOLOGY, Jan. 2009, p. 347–354 Vol. 191, No. 1 0021-9193/09/$08.00ϩ0 doi:10.1128/JB.01238-08 Copyright © 2009, American Society for Microbiology. All Rights Reserved. Complete Genome Sequence and Comparative Genome Analysis of Enteropathogenic Escherichia coli O127:H6 Strain E2348/69ᰔ† Atsushi Iguchi,1 Nicholas R. Thomson,2 Yoshitoshi Ogura,1,3 David Saunders,2 Tadasuke Ooka,3 Ian R. Henderson,4 David Harris,2 M. Asadulghani,1 Ken Kurokawa,5 Paul Dean,6 Brendan Kenny,6 Michael A. Quail,2 Scott Thurston,2 Gordon Dougan,2 Tetsuya Hayashi,1,3 Julian Parkhill,2 and Gad Frankel7* Division of Bioenvironmental Science, Frontier Science Research Center,1 and Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine,3 University of Miyazaki, Miyazaki, Japan; Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom2; School of Immunity and Infection, University of Downloaded from Birmingham, Birmingham, United Kingdom4; Department of Biological Information, School and Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa, Japan5; Institute of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom6; and Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom7 Received 5 September 2008/Accepted 15 October 2008 Enteropathogenic Escherichia coli (EPEC) was the first pathovar of E. coli to be implicated in human disease; however, no EPEC strain has been fully sequenced until now. Strain E2348/69 (serotype O127:H6 belonging to E. http://jb.asm.org/ coli phylogroup B2) has been used worldwide as a prototype strain to study EPEC biology, genetics, and virulence. -
Holding Hands with Bacteria the Life and Work of Marjory Stephenson
SPRINGER BRIEFS IN MOLECULAR SCIENCE HISTORY OF CHEMISTRY Soňa Štrbáňová Holding Hands with Bacteria The Life and Work of Marjory Stephenson 123 SpringerBriefs in Molecular Science History of Chemistry Series editor Seth C. Rasmussen, Fargo, North Dakota, USA More information about this series at http://www.springer.com/series/10127 Soňa Štrbáňová Holding Hands with Bacteria The Life and Work of Marjory Stephenson 1 3 Soňa Štrbáňová Academy of Sciences of the Czech Republic Prague Czech Republic ISSN 2191-5407 ISSN 2191-5415 (electronic) SpringerBriefs in Molecular Science ISSN 2212-991X SpringerBriefs in History of Chemistry ISBN 978-3-662-49734-0 ISBN 978-3-662-49736-4 (eBook) DOI 10.1007/978-3-662-49736-4 Library of Congress Control Number: 2016934952 © The Author(s) 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. -
Microbiology Society Activities
MICROBIOLOGY TODAY 48:1 May 2021 Microbiology Today 48:1 May 2021 Life on a Changing Planet Life on a Changing Planet Exploring the relationship between climate change and the microbial world Forest Fire in Dixie National Forest, Utah, USA. santirf/iStock which in turn increase the risk of COVID-19 complications. impact on respiratory health of affected communities. Curr Opin Pulm Wildfire smoke exposure might also increase the likelihood of Med 2019;25:179–187. comorbidities, including cardiovascular diseases, respiratory Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. Air pollution and diseases, diabetes and hypertension, leading to an increased COVID-19 mortality in the United States: strengths and limitations of an ecological regression analysis. Sci Adv 2020;6:eabd4049. COVID-19 risk. Higher daily average PM2.5 concentrations during the wildfire season in western US states were positively Gosling SN, Bryce EK, Dixon PG, Gabriel KMA, Gosling EY et al. associated with increased influenza rates the following A glossary for biometeorology. Int J Biometeorol 2014;58:277–308. winter, indicating strong evidence for delayed effects of wildfire exposure. Research on understanding the underlying mechanisms between wildfire exposure and respiratory Rosa von Borries infection is an area of active investigation. Consultant at World Meteorological Organization, In particular, vulnerable population groups such as socio- Bernhard-Lichtenberg-Str 15, 10407 Berlin, economically disadvantaged populations, individuals with Germany comorbidities and the elderly face higher risks of experiencing [email protected] the combined consequences of COVID-19 and wildfires. @rosavborries In the US, migrant farmworkers who were continuously linkedin.com/in/rosa-von-borries-5b4987197 exposed to wildfire smoke and deemed essential workers during the pandemic faced much higher risks of severe Rosa von Borries holds an MSc in Public Health from London School health consequences from wildfire smoke and COVID-19. -
Quadram Institute Newsletter
Autumn 2019 Welcome to the newsle�er of the Quadram Ins�tute. This issue highlights recent research breakthroughs at the We con�nue to build our team and are pleased to welcome Quadram Ins�tute (QI) that could have posi�ve impacts on Professor Cynthia Whitchurch to the QI. Cynthia is se�ng public health. Working with clinicians our researchers have up a research group inves�ga�ng bacterial lifestyles, and shown how the latest sequencing technologies can aid in how these make them more infec�ous or resistant to diagnos�cs and surveillance. Coupling these techniques an�microbials. Cynthia joins us from the ithree ins�tute at with ‘Big Data’ analy�cal approaches will be vital to the University of Technology Sydney. Her research led to addressing 21st century popula�on health challenges, and the discovery that extracellular DNA is required for biofilm the QI aims to be a leader in this area. development. Big Data in the NHS was the topic of a roundtable We con�nue to welcome visitors to our new building to discussion I a�ended with Patricia Hart at the policy share our vision to understand how food and microbes development think tank Reform. This roundtable was interact to promote health and prevent disease. In June, we sponsored by QI and explored how universi�es and industry had the honour of hos�ng His Excellency Simon Smits, can work with government to realise poten�al applica�ons Ambassador of the Netherlands to the UK. The Ambassador of Big Data. The event was chaired by Baroness Blackwood, visited the Norwich Research Park as part of an Parliamentary Under-Secretary of State, Department of interna�onal trade delega�on to East Anglia to learn about Health and Social Care (DHSC) and included senior the region’s world-leading life sciences research and trade policy-makers, public service prac��oners, academics and opportuni�es. -
Curriculum Vitae Professor Mark John Pallen
Curriculum Vitae Professor Mark John Pallen MA (Hons) Cantab, MBBS, MD, PhD January 2014 Mark Pallen — Curriculum vitae Personal Details Name Mark John Pallen Date of Birth 6 July 1960 Nationality British Address 17 Lodge Drive, Malvern Worcestershire, WR14 4LS E-mail address [email protected] Telephone 01684 567710 (home); 07824 086946 (mobile) Web Page: http://tinyurl.com/ncul2p3 Twitter: http://twitter.com/mjpallen YouTube Channel: http://www.youtube.com/user/pallenm/ Education and Qualifications PhD 1998 Imperial College, London An investigation into the links between stationary phase and virulence in Salmonella enterica enterica serovar Typhimurium MD 1993 St Bartholomew's Hospital Medical College Detection and characterisation of diphtheria toxin genes and insertion sequences MRCPath by examination in Medical Microbiology 1991 (upgraded to FRCPath 2005) MB BS 1981-84 London Hospital Medical College Undergraduate Prizes: LEPRA National Essay Prize, 1982 Turnbull Prize in Pathology, 1983, 1984 Sutton Prize in Pathology, 1983 BA (Hons) in Medical Sciences 1978-81 University of Cambridge Fitzwilliam College (Lower Second, converted to MA, 1985) Page 1 Mark Pallen — Curriculum vitae Employment Professor of Microbial Genomics Head of Division of Microbiology and Infection Apr 2013-now Warwick Medical School, University of Warwick Professor of Microbial Genomics 2001-2013 University of Birmingham Professor and Head of Department 1999-2001 Department of Microbiology and Immunobiology Queen’s University, Belfast Senior Lecturer (Honorary Consultant) 1992–99 Department of Medical Microbiology St Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary Westfield College) Visiting Research Fellow 1994–97 Department of Biochemistry Imperial College of Science, Technology and Medicine (on a Wellcome Trust Research Leave Fellowship, working at Imperial, while still employed by Barts) Lecturer (Hon. -
The Foot-And-Mouth Disease Virus Replication Complex
The Foot-and-Mouth Disease Virus Replication Complex: Dissecting the Role of the Viral Polymerase (3Dpol) and Investigating Interactions with Phosphatidylinositol-4-kinase (PI4K) Eleni-Anna Loundras Submitted in accordance with the requirements for the degree of Doctor of Philosophy The University of Leeds School of Molecular and Cellular Biology August 2017 The candidate confirms that the work submitted is her own, except where work which has formed part of jointly authored publications has been included. The contribution of the candidate and the other authors to this work has been explicitly indicated below. The candidate confirms that appropriate credit has been given within the thesis where reference has been made to the work of others. The work appearing in Chapter 3 and Chapter 4 of the thesis has appeared in publications as follow: • Employing transposon mutagenesis in investigate foot-and-mouth disease virus replication. Journal of Virology (2015), 96 (12), pp 3507-3518., DOI: 10.1099/jgv.0.000306. Morgan R. Herod (MRH), Eleni-Anna Loundras (EAL), Joseph C. Ward, Fiona Tulloch, David J. Rowlands (DJR), Nicola J. Stonehouse (NJS). The author (EAL) was responsible for assisting with preparation of experiments and production of experimental data. MRH, as primary author drafted the manuscript and designed the experiments. NJS and DJR conceived the idea, supervised the project, and edited the manuscript. • Both cis and trans activities of foot-and-mouth disease virus 3D polymerase are essential for viral replication. Journal of Virology (2016), 90 (15), pp 6864-688., DOI: 10.1128/JVI.00469-16. Morgan R. Herod, Cristina Ferrer-Orta, Eleni-Anna Loundras, Joseph C. -
Exploratory Experimentation and Scientific Practice: Metagenomics and the Proteorhodopsin Case
Forthcoming in: History and Philosophy of the Life Sciences (2007), 29 (3): 335-358 Exploratory experimentation and scientific practice: Metagenomics and the proteorhodopsin case Maureen A. O’Malley Egenis, University of Exeter Byrne House, St Germans Road Exeter, EX4 4PJ, UK ABSTRACT Exploratory experimentation and high-throughput molecular biology appear to have considerable affinity for each other. Included in the latter category is metagenomics, which is the DNA-based study of diverse microbial communities from a vast range of non-laboratory environments. Metagenomics has already made numerous discoveries and these have led to reinterpretations of fundamental concepts of microbial organization, evolution and ecology. The most outstanding success story of metagenomics to date involves the discovery of a rhodopsin gene, named proteorhodopsin, in marine bacteria that were never suspected to have any photobiological capacities. A discussion of this finding and its detailed investigation illuminates the relationship between exploratory experimentation and metagenomics. Specifically, the proteorhodopsin story indicates that a dichotomous interpretation of theory-driven and exploratory experimentation is insufficient, and that an interactive understanding of these two types of experimentation can be usefully supplemented by another category, ‘natural history experimentation’. Further reflection on the context of metagenomics suggests the necessity of thinking more historically about exploratory and other forms of experimentation. Forthcoming -
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