S720 14th International Congress of Endocrinology

Sat. March 27 Scientific Program

Plenary Lectures Room 1

PL1 8:25 - 9:10 Chairperson: Kenji Kangawa National Cardiovascular Center Research Institute, Osaka, Japan Bowels control brain - gut hormones and obesity Stephen R. Bloom Imperial College London, UK

PL2 16:10 - 16:55 Chairperson: Hajime Nawata Fukuoka Prefectural University, Fukuoka, Japan Insulin signaling molecules and pathogenesis of type 2 diabetes mellitus Masato Kasuga Research Institute, International Medical Center of Japan

PL3 16:55 - 17:40 Chairperson: Toshio Matsumoto Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, Japan Parathyroid hormone’s actions on bone Henry M. Kronenberg Massachusetts General Hospital, USA

Meet-the-Professor 11:10-12:00

MTP1 Management of diabetes and cardiovascular protection Room 2 Chairpersons: Rury R. Holman Diabetes Trials Unit, The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK Peter Gaede Steno Diabetes Center, Denmark MTP1-1 Management of diabetic nephropathy Ryuichi Kikkawa Shiga University of Medical Science, Otsu, Japan MTP1-2 Management of diabetes and cardiovascular protection Rury R. Holman Diabetes Trials Unit, The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK

MTP2 Primary aldosteronism Room 3 Chairpersons: Franco Mantero Department of Medical and Surgical Sciences, University of Padua, Italy Ching-Chung Chang The Endocrine Society of the Republic of China, Taiwan MTP2-1 Current issues on the diagnosis and treatment of primary aldosteronism Sadayoshi Ito Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, Sendai, Japan MTP2-2 Primary aldosteronism Franco Mantero Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padua, Italy

MTP3 * GH and IGF-1 deficiency Room 4 Chairpersons: Ron G. Rosenfeld Department of Pediatrics, Oregon Health & Science University, USA Kazuo Chihara Hyogo Prefectural Kakogawa Medical Center, Japan MTP3-1 Novel syndrome of growth hormone deficiency: adult combined GH, PRL and TSH deficiency associated with circulating anti-PIT-1 antibody Yutaka Takahashi Department of Internal Medicine, Division of Diabetes, Metabolism and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan MTP3-2 Diagnosis and management of IGF deficiency Ron G. Rosenfeld Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA

MTP4 * Estrogen action and disease Room 5 Chairpersons: Evan R. Simpson Prince Henry’s Institute of Medical Research, Australia Hideo Honjo Aiseikai Yamashina Hospital, Kyoto, Japan MTP4-1 Genetic Mutations of CYP19A1 in humans Makio Shozu Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Japan MTP4-2 The link between the LKB1/AMPK pathway and aromatase in the breast provides a link between obesity and breast cancer Evan R. Simpson Prince Henry’s Institute of Medical Research, Australia Scientific Program Sat. March 27 S721

MTP5 * Obesity and hypothalamo-pituitary axis Room 6 Chairpersons: Felipe F. Casanueva Department of Medicine, University of Santiago de Compostela, Santiago de Compostela University Hospital Complex, Spain Shigeru Matsukura Chiyoda Hospital, Miyazaki, Japan MTP5-1 Obesity and central regulation of appetite Masamitsu Nakazato Department of Internal Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, University of Miyazaki, Miyazaki, Japan MTP5-2 Obesity and hypothalamo-pituitary axis Felipe F. Casanueva Department of Medicine, University of Santiago de Compostela, Santiago de Compostela University Hospital Complex, Spain

MTP6 Graves’ disease Room 7 Chairpersons: Valeria Guimaraes Physician-Clinical Practitioner, ENNE, Brazil Toru Mori Higashiyamatakeda Hospital, Kyoto, Japan MTP6-1 Antithyroid drug therapy of Graves’ disease: Methimazole or propylthiouracil and how much of the dosage? Hirotoshi Nakamura Department of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan MTP6-2 TBD Terry F. Davies Mount Sinai School of Medicine, USA

MTP7 Andropause Room 8 Chairpersons: Ilpo T. Huhtaniemi Department of Surgery and Cancer, Division of Cancer, Reproductive Biology, Clinical Obstetrics and Gynaecology, Imperial College London, London, UK Gianni Forti Endocrine Unit, Department of Physiopathology, University of Florence, Italy MTP7-1 Effects of testosterone replacement therapy for late-onset hypogonadism patients mainly suffering from psychological symptoms Tadashi Matsuda Department of Urology and Andrology, Kansai Medical University, Hirakata, Japan MTP7-2 Andropause - Fact or fiction? Ilpo T. Huhtaniemi Department of Surgery and Cancer, Division of Cancer, Reproductive Biology, Clinical Obstetrics and Gynaecology, Imperial College London, London, UK

MTP8 Cardiac natriuretic peptides Room 9 Chairpersons: M. Gary Nicholls Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand Yoshihiko Saito First Department of Internal Medicine, Nara Medical University, Japan MTP8-1 Positioning of rapid BNP assay in the emergency room and intensive care unit Michihiro Yoshimura The Jikei University School of Medicine, Tokyo, Japan MTP8-2 Cardiac natriuretic peptides: Looking to the future M. Gary Nicholls Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand

MTP9 * FGF family and disease Room 10 Chairpersons: Kenneth E. White Indiana University School of Medicine, USA Yasuo Imanishi Osaka City University Graduate School of Medicine, Osaka, Japan MTP9-1 Evolution and functional diversity of the Fgf gene family Nobuyuki Itoh Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan 27 March Sat. MTP9-2 Fibroblast growth factor-23 (FGF23) Kenneth E. White Indiana University School of Medicine, USA

MTP10 Diabetes insipidus Room 15 Chairpersons: Soren Rittig Pediatric Research Center, Department of Pediatrics, Aarhus University Hospital, Denmark San-e Ishikawa Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan MTP10-1 Subclinical diabetes insipidus Yasumasa Iwasaki Health Care Center, Kochi University, Kochi, Japan MTP10-2 Diabetes insipidus - Translational aspects Soren Rittig Pediatric Research Center Skejby, Department of Pediatrics, Aarhus University Hospital, Denmark

* Basic/TR S722 14th International Congress of Endocrinology

Symposia 9:20-11:00

SY1-1 Molecular basis for insulin resistance and diabetes Room 2 Chairpersons: Morris F. White Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA Wataru Ogawa Kobe University Graduate School of Medicine, Japan SY 1-1-1 * Mechanism of insulin resistance and the rational path to a cure Morris F. White Howard Hughes Medical Institute, Division of Endocrinology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA SY 1-1-2 Regulation of insulin action and secretion by SOCS proteins and microRNAs Emmanuel Van Obberghen Department of Biochemistry and Molecular Biology, and INSERM Unit 907, Faculty of Medicine, University of Nice Sophia Antipolis; SY 1-1-3 Transcriptional regulation of hepatic energy metabolism Wataru Ogawa Kobe University Graduate School of Medicine, Japan SY 1-1-4 Role of liver transcription ChREBP in the the development of hepatic steatosis in mouse and human liver Catherine Postic Departement of Endocrinology, Metabolism and Cancer, Cochin Institute, Inserm U1016, France

SY1-3 Regulation of pancreatic beta cell mass Room 5 Chairpersons: Rohit N. Kulkarni Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Yasuo Terauchi Department of Endocrinology and Metabolism, Yokohama City University, Yokohama, Japan SY 1-3-1 * Growth factor signaling in the regulation of ER stress and pancreatic beta cell mass Rohit N. Kulkarni Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA SY 1-3-2 Regulation of pancreatic beta cell mass Harry Heimberg Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium SY 1-3-3 Role of glucokinase on pancreatic beta-cell mass and impact of glucokinase activator on the regulation of beta-cell mass Yasuo Terauchi Department of Endocrinology and Metabolism, Yokohama City University, Yokohama, Japan SY 1-3-4 Role of autophagy in the regulation of pancreatic β-cell mass and function Hye S. Jung Seoul National University Hospital, Republic of Korea

SY1-7 Diabetic complications Room 10 Chairpersons: George L. King Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Masakazu Haneda Department of Medicine, Asahikawa Medical College, Asahikawa, Japan SY 1-7-1 * Diabetic complications- Mechanisms beyond oxidative stress George L. King Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA SY 1-7-2 Canceled SY 1-7-3 Pathogenic role of mitochondrial reactive oxygen species in diabetes and its complications Takeshi Nishikawa Department of Metabolic Medicine, Kumamoto University, Kumamoto, Japan SY 1-7-4 Pathogenesis of diabetic nephropathy: Role of hypoxia-inducible factor-1α (HIF-1α) Masakazu Haneda Department of Medicine, Asahikawa Medical College, Asahikawa, Japan

SY3-4 Peptide networks in energy metabolism Room 6 Chairpersons: Yukari Date Frontier Science Research Center, University of Miyazaki, Japan Kevin L. Grove Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA SY 3-4-1 * A new neural circuit by hypothalamic peptides relative to feeding behavior Yukari Date Frontier Science Research Center, University of Miyazaki, Japan SY 3-4-2 Leptin insufficiency in the hypothalamus confers disease cluster of metabolic syndrome: A new insight Satya P. Kalra Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA SY 3-4-3 Development of hypothalamic neuropeptide systems: Impact of maternal health and diet Kevin L. Grove Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA SY 3-4-4 Roles of orexins in regulation of energy homeostasis Takeshi Sakurai Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Japan Scientific Program Sat. March 27 S723

9:20-11:00 Symposia * State-of- the-art

SY3-7 New peptides in comparative endocrinology Room 11 Chairpersons: Hubert Vaudry Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, France Kazushige Touhara Department of Applied Biological Chemistry, The University of Tokyo, Japan SY 3-7-1 * The unique contribution of amphibians to the discovery of novel neuropeptides Hubert Vaudry Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, France; European Institute for Peptide Research (IFRMP 23), University of Rouen, France; Regional Platform for Cell Imaging (PRIMACEN) SY 3-7-2 The peptide pheromone ESP1 enhances sexual receptive behavior in female mice via a select vomeronasal receptor Kazushige Touhara Department of Applied Biological Chemistry, The University of Tokyo, Japan SY 3-7-3 Novel hypothalamic peptides and receptors in a basal vertebrate, the sea lamprey Stacia A. Sower Center for Molecular and Comparative Endocrinology, University of New Hampshire, Durham, New Hampshire, USA SY 3-7-4 Discovery and functional significance of gonadotropin-inhibitory hormone (GnIH) in vertebrates: From comparative to general Kazuyoshi Tsutsui Department of Biology, Waseda University, Tokyo, Japan

SY4-3 Animal models of Graves’ disease Room 14 Chairpersons: Marian Ludgate School of Medicine, Cardiff University, UK Yuji Nagayama Department of Medical Gene Technology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan SY 4-3-1 * Animal models of Graves’ disease Marian Ludgate School of Medicine, Cardiff University, UK SY 4-3-2 Human versus mouse thyrotropin receptor as an autoantigen in a mouse model of Graves’ hyperthyroidism Yuji Nagayama Department of Medical Gene technology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan SY 4-3-3 Animal models of Graves’ disease Sandra M. McLachlan Cedars-Sinai Medical Center and UCLA, USA SY 4-3-4 Animal models of Graves’ disease Gattadahalli S. Seetharamaiah Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA

SY4-6 Thyroid hormone metabolism Room 7 Chairpersons: Antonio C. Bianco Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA Yoshiharu Murata Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan SY 4-6-1 * Thyroid hormone deiodination is a cell-specific mechanism to control thyroid hormone signaling Antonio C. Bianco Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, USA SY 4-6-2 The skeletal consequences of altered thyroid hormone metabolism J. H. Duncan Bassett Imperial College London, UK SY 4-6-3 The local control of thyroid hormone action in the balance between proliferation and differentiation at cellular level 27 March Sat. Domenico Salvatore Department of Endocrinology and Molecular and Clinical Oncology, The University of Naples Federico II, Naples, Italy SY 4-6-4 Increased thyroidal type 2 iodothyronine deiodinase (D2) activity may account for serum T3 predominance over T4 in patients with abnormal thyroglobulin (Tg) or sodium/iodine symporter (NIS) Yoshiharu Murata Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

SY5-5 Bone biology Room 4 Chairpersons: Roland Baron Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA Shu Takeda Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Japan SY 5-5-1 * Molecular and cellular basis of bone remodeling and their implications for the treatment of bone diseases Roland Baron Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA SY 5-5-2 Cross-talk between bone and other organs Shu Takeda Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Japan SY 5-5-3 Endocrine and paracrine regulation of osteoblasts, osteoclasts and osteocytes Natalie A. Sims St. Vincent’s Institute of Medical Research, Australia SY 5-5-4 The pituitary-bone axis Jameel Iqbal Mount Sinai School of Medicine, New York, USA S724 14th International Congress of Endocrinology

Symposia 9:20-11:00

SY7-4 Vasopressin agonist and antagonist Room 8 Chairpersons: San-e Ishikawa Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan Joseph G. Verbalis Department of Medicine, Georgetown University, Washington, DC, USA SY 7-4-1 * Arginine vasopressin agonists and antagonists: Development and clinical use San-e Ishikawa Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan SY 7-4-2 Vasopressin receptor antagonists: Past, present and future Joseph G. Verbalis Department of Medicine, Georgetown University, Washington, DC, USA SY 7-4-3 The pathogenesis of osmotic demyelination syndrome (ODS) and the therapy to prevent ODS Yoshihisa Sugimura Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan SY 7-4-4 Discovery of nonpeptide vasopressin receptor modulators Kazumi Kondo Qs’ Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan

SY7-5 Hypothalamus: Differentiation and development Room 15 Chairpersons: Sergio R. Ojeda Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA Stuart A. Tobet Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA SY 7-5-1 * The epigenetics of mammalian puberty Sergio R. Ojeda Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA SY 7-5-2 Ultradian oscillation of GnRH gene expression in the mouse hypothalamic slices Kyungjin Kim School of Biological Sciences, Seoul National University, Seoul, Republic of Korea SY 7-5-3 Mechanisms of hypothalamic development: Spotlight on cell grouping Stuart A. Tobet Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA SY 7-5-4 Epigenetic regulation of hypothalamic-pituitary adrenal axis and corticotrophin releasing hormone transcription by early life stress Greti Aguilera Section on Endocrine Physiology, Program in Development Endocrinology and Genetics, National institute of Child Health and Human Development, USA

SY11-2 Mechanism of sex differentiation and development Room 3 Chairpersons: Richard R. Behringer Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA Gen Yamada The Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan SY 11-2-1 * Genetic regulation of female reproductive tract development Richard R. Behringer Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA SY 11-2-2 A model for the development of sexual dimorphism: Wnt signal mediated external genitalia masculinization Gen Yamada The Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan SY 11-2-3 Establishment and reprogramming of somatic sex in mammals Ryohei Sekido Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK SY 11-2-4 Disorders of androgen production and action: Molecular etiology and beyond Elaine M. F. Costa The Developmental Endocrine Unit, Clinical Hospital, University of Sao Paulo, Sao Paulo, Brazil

SY12-2 Angiogenesis Room 9 Chairpersons: Hyo-Soo Kim Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea Yuichi Oike Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan SY 12-2-1 * Angiogenic cell therapy for ischemic disease Toyoaki Murohara Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan SY 12-2-2 Strategies to enhance the vasculogenic potential of endothelial progenitor cells Hyo-Soo Kim Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea SY 12-2-3 Angiopoietin-like proteins: Potential therapeutic targets for metabolic syndrome and cardiovascular disease Yuichi Oike Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan SY 12-2-4 Novel roles of cyclic AMP pathway in endothelial cell differentiation and specification Jun K. Yamashita Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan Scientific Program Sat. March 27 S725

9:20-11:00 Symposia * State-of- the-art

SY13-5 Molecular basis of congenital hypothyroidism Room 13 Chairpersons: Annette Grüters University Children’s Hospital Charité, Berlin, Germany Kazumichi Onigata Department of Pediatrics, Shimane University Faculty of Medicine, Japan SY 13-5-1 * Molecular basis of congenital hypothyroidism Annette Grüters University Children’s Hospital Charité, Berlin, Germany SY 13-5-2 Clinical faces of H2O2 generation defects of the thyroid Jose C. Moreno Institute for Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Spain SY 13-5-3 Studies on the potential involvement of a novel pathway in congenital hypothyroidism (CH) Luca Persani Department of Medical Sciences, The Italian Institute for Auxology, University of Milan, Italy SY 13-5-4 Phenotype of subjects with inactivating thyrotropin receptor gene mutations Kazumichi Onigata Department of Pediatrics, Shimane University Faculty of Medicine, Japan

SY14-2 TRP channels Room 12 Chairpersons: Thomas Gudermann Walther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Germany Yasuo Mori Graduate School of Engineering, Kyoto University, Japan SY 14-2-1 * TRPC channels in the cardiopulmonary system Thomas Gudermann Walther-Straub-Institute of Pharmacology and Toxicology, University of Munich, Germany SY 14-2-2 Redox-sensitive TRP channels Yasuo Mori Graduate School of Engineering, Kyoto University, Japan SY 14-2-3 TRPM2 channel - A Jack of all trades Reinhold Penner The Queen’s Medical Center, University of Hawai‘i, USA SY 14-2-4 Phosphorylation-based modal regulation of mechanically- and receptor-activated cardiovascular Ca2+ entry channel TRPC6 Ryuji Inoue Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, Fukuoka, Japan

SY15-2 Primary aldosteronism Room 1 Chairpersons: William F. Young Jr. Mayo Clinic, Rochester, MN, USA Tetsuo Nishikawa Department of Medicine, Division of Endocrinology and Metabolism, Yokohama Rosai Hospital, Yokohama, Japan SY 15-2-1 * Primary aldosteronism: State of the art William F. Young Jr. Mayo Clinic, Rochester, MN, USA SY 15-2-2 An update on primary aldosteronism Michael Stowasser Endocrine Hypertension Research Centre, University of Queensland School of Medicine, Greenslopes and Princess Alexandra Hospitals, Brisbane, Australia SY 15-2-3 Prevalence of primary aldosteronism (PA) in Japan - Unexpectedly high incidence of unilateral CT-undetectable adrenal lesion- Sat. March 27 March Sat. Tetsuo Nishikawa Department of Medicine, Division of Endocrinology and Metabolism, Yokohama Rosai Hospital, Yokohama, Japan SY 15-2-4 Metabolic and cardiovascular complications of primary aldosteronism Martin Reincke Medizinische Klinik Innenstadt, Klinikum der Ludwig-Maximilians-Universität München, Germany

S726 14th International Congress of Endocrinology

Symposia 14:20-16:00

SY1-2 Genetics of diabetes Room 5 Chairpersons: Leif Groop Lund University Diabetes Centre, Malmo, Sweden Kazuki Yasuda Research Institute, International Medical Center of Japan, Tokyo, Japan SY 1-2-1 * Genetics of type 2 diabetes - Are we getting any closer? Leif Groop Lund University Diabetes Centre, Malmo, Sweden SY 1-2-2 TBD Hans Häring University Hospital of Tubingen, Germany SY 1-2-3 Genetic analyses of type 2 diabetes mellitus in Japan Kazuki Yasuda Research Institute, International Medical Center of Japan, Tokyo, Japan SY 1-2-4 Identification of susceptibility loci for nephropathy in diabetes Andrzej S. Krolewski Joslin Diabetes Center and Harvard Medical School, USA

SY1-4 Beta cell biology Room 8 Chairpersons: Claes B. Wollheim Department of Cell Physiology and Metabolism, University Medical Centre, Geneva, Switzerland Itaru Kojima Institute for Molecular and Cellular Regulation, Gunma University, Japan SY 1-4-1 * Importance of beta cell mitochondrial calcium in glucose-stimulated insulin secretion Claes B. Wollheim Department of Cell Physiology and Metabolism, University Medical Centre, Geneva, Switzerland SY 1-4-2 Sweet taste receptor expressed in pancreatic β-cells regulates insulin secretion by modulating the calcium and cAMP messenger systems Itaru Kojima Institute for Molecular and Cellular Regulation, Gunma University, Japan SY 1-4-3 Cyclic AMP signalling in glucose-induced insulin secretion Anders Tengholm Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden SY 1-4-4 Autophagy in pancreatic beta cells Hirotaka Watada Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan

SY1-6 Clinical trials in diabetes Room 7 Chairpersons: Atsunori Kashiwagi University Hospital, Shiga University of Medical Science, Shiga, Japan Mark E. Cooper Baker IDI Heart & Diabetes Institute, Melbourne, Australia SY 1-6-1 * Microalbuminuria as a cardiovascular risk factor in type 2 diabetes Atsunori Kashiwagi Department of Medicine, Shiga University of Medical Science, Otsu, Japan SY 1-6-2 Clinical trials in diabetic complications Mark E. Cooper Baker IDI Heart & Diabetes Institute, Melbourne, Australia SY 1-6-3 Multifactorial intervention in patients with type 2 diabetes - How much can be gained and how low should we go? Peter Gæde Steno Diabetes Center, Copenhagen, Denmark SY 1-6-4 Glycaemic exposure and vascular outcomes in the ADVANCE trial Anushka A. Patel The George Institute for International Health, University of Sydney, Sydney, Australia

SY1-8 Skeletal muscle and diabetes Room 14 Chairpersons: Bente Klarlund Pedersen Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark Tatsuya Hayashi Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan SY 1-8-1 * The diseasome of physical inactivity ñ and the role of myokines Bente Klarlund Pedersen Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark SY 1-8-2 TBC1D1/D4 - A multi kinase target integrating insulin- and exercise-induced metabolic signals Joergen F.P. Wojtaszewski Molecular Physiology Group, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark SY 1-8-3 Muscle contraction as a physiological stimulator of glucose metabolism Tatsuya Hayashi Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan SY 1-8-4 Role of myokines in metabolic regulation Mark A. Febbraio Cellular and Molecular Metabolism Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, VIC, Australia Scientific Program Sat. March 27 S727

14:20-16:00 Symposia * State-of- the-art

SY3-2 Ghrelin: Clinical application Room 1 Chairpersons: Michael O. Thorner Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia, USA Masamitsu Nakazato Department of Internal Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, University of Miyazaki, Miyazaki, Japan SY 3-2-1 * Potential role of ghrelin mimetics in preventing frailty and partially reversing sarcopenia of aging Michael O. Thorner Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia, USA SY 3-2-2 The central ghrelin signalling system is required for alcohol and food reward Suzanne L. Dickson The Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden SY 3-2-3 Clinical application of ghrelin for chronically exhausted disorders Masamitsu Nakazato Department of Internal Medicine, Division of Neurology, Respirology, Endocrinology and Metabolism, University of Miyazaki, Miyazaki, Japan SY 3-2-4 Beta-cell survival and function: The role of ghrelin and obestatin Riccarda Granata Department of Internal Medicine, Division of Endocrinology, Diabetology and Metabolism, University of Turin, Turin, Italy

SY3-5 Peptidomics and new peptides Room 11 Chairpersons: Per E. Andrén Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden Naoto Minamino Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan SY 3-5-1 * Strategies for specific and sensitive identification of neuropeptides Per E. Andrén Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden SY 3-5-2 Peptidomics-based discovery of bioactive peptides: Identification of neuroendocrine regulatory peptides and their precursor processing pathway Naoto Minamino Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan SY 3-5-3 Peptidomics of classical and non-classical neuropeptides in brain: From discovery to function Lloyd D. Fricker Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA SY 3-5-4 Peptide discovery: Past, present & future: Peptidomics in fundamental and applied research Jurgen Huybrechts Department of Biology, Research Group of Functional Genomics and Proteomics, The Catholic University of Leuven, Belgium

SY4-4 Subclinical hypothyroidism and arteriosclerosis Room 3 Chairpersons: Paul W. Ladenson Johns Hopkins Medical Institutions, Baltimore, USA Nobuyuki Takasu University of the Ryukyus, Okinawa, Japan SY 4-4-1 * Subclinical hypothyroidism and cardiovascular disease across the spectrum of aging Paul W. Ladenson Johns Hopkins Medical Institutions, Baltimore, USA SY 4-4-2 Subclinical hypothyroidism and atherosclerosis: What do the cohort studies tell us? John P. Walsh Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia SY 4-4-3 Subtle thyroid failure in the elderly 27 March Sat. Fabio Monzani Department of Internal Medicine, University of Pisa, Pisa, Italy SY 4-4-4 Subclinical hypothyroidism and arteriosclerosis Salman S. Razvi Department of Endocrinology, Gateshead Health NHS Foundation Trust, UK

SY5-1 FGF23 Room 6 Chairpersons: Kenneth E. White Indiana University School of Medicine, USA Seiji Fukumoto Department of Medicine, Division of Nephrology and Endocrinology, University of Tokyo Hospital, Japan SY 5-1-1 * FGF23 and phosphate homeostasis Kenneth E. White Indiana University School of Medicine, USA SY 5-1-2 FGF23 as a phosphotropic hormone Seiji Fukumoto Department of Medicine, Division of Nephrology and Endocrinology, University of Tokyo Hospital, Japan SY 5-1-3 Is Klotho essential for FGF23-mediated endocrine regulation of phosphate homeostasis? Mohammed S. Razzaque Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, USA SY 5-1-4 FGF23 and Klotho Makoto Kuro-o Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA S728 14th International Congress of Endocrinology

Symposia 14:20-16:00

SY7-8 New aspects of vasopressin action Room 12 Chairpersons: Harold Gainer NIH, NINDS, Bethesda, MD, USA Yoichi Ueta Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan SY 7-8-1 * Recent progress in understanding the regulation of the cell-specific expression of oxytocin and vasopressin genes in the hypothalamus Harold Gainer NIH, NINDS, Bethesda, MD, USA SY 7-8-2 The expression of the vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamo-pituitary system in rats: A new aspect of vasopressin dynamics Yoichi Ueta Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan SY 7-8-3 New aspects of vasopressin action Gareth Leng University of Edinburgh, UK SY 7-8-4 The role of vasopressin in sexual differentiation of the brain Geert J. de Vries Center for Neuroendocrine Studies, University of Massachusetts, Amherst, USA

SY9-6 Aldosterone and disease Room 2 Chairpersons: Gian Paolo Rossi Department of Clinical and Experimental Medicine, Internal Medicine 4, University of Padua, Italy Michihiro Yoshimura The Jikei University School of Medicine, Tokyo, Japan SY 9-6-1 * Aldosterone and disease Gian Paolo D. Rossi Department of Clinical and Experimental Medicine, Internal Medicine 4, University of Padua, Italy SY 9-6-2 Sodium and glucose regulation by aldosterone in rat cardiomyocytes Michihiro Yoshimura The Jikei University School of Medicine, Tokyo, Japan SY 9-6-3 Genetic regulation of aldosterone production in cardiovascular disease John M. Connell University of Dundee, Dundee, UK SY 9-6-4 Aldosterone stimulates transcription of ICAM-1 via SGK-1 in rat mesangial cells in vivo and in vitro Yoshio Terada Kochi Medical School, Japan

SY10-1 Endocrine-related cancers Room 9 Chairpersons: Sheue-yann Cheng Laboratory of Moleculer Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA Junn Yanagisawa TARA center, University of Tsukuba, Tsukuba Science City, Japan SY 10-1-1 * Regulation of metastasis in follicular carcinoma of the thyroid: Insights from a mouse model Sheue-yann Cheng Laboratory of Moleculer Biology, Center for Canser Research, National Canser Institute, Bethesda, MD, USA SY 10-1-2 Androgen dependence and its alteration in human prostate cancer: Revisiting prostate specific protein tyrosine phosphatase Tsukasa Igawa Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan SY 10-1-3 Breast cancer - Achievements and challenges Robert C.F. Leonard Human Cancer Studies Group, Imperial College London, UK SY 10-1-4 Tumor progression and non-genomic function of nuclear receptors Junn Yanagisawa TARA center, University of Tsukuba, Tsukuba Science City, Japan

SY10-4 Recent management of acromegaly Room 10 Chairpersons: Albert Beckers Department of Endocrinology, University of Liege, Liege, Belgium Kazunori Arita Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan SY 10-4-1 * Short and long term effects of transsphenoidal surgery on growth hormone producing pituitary adenomas : Based on experiences with 290 patients Kazunori Arita Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan SY 10-4-2 Surgery followed by gamma knife radiosurgery for treatment of acromegaly Marco Losa Department of Neurosurgery, The Vita-Salute San Raffaele University, Milan, Italy SY 10-4-3 FIPA (Familial Isolated Pituitary Adenomas) Albert Beckers Department of Endocrinology, University of Liege, Liege, Belgium SY 10-4-4 TBD Marily Theodoropoulou Department of Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany Scientific Program Sat. March 27 S729

14:20-16:00 Symposia * State-of- the-art

SY11-1 Steroidogenic gene regulation Room 15 Chairpersons: Douglas M. Stocco Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, USA Matti Poutanen Institute of Biomedicine, University of Turku, Finland SY 11-1-1 * The compartmentalization of signals regulating StAR Douglas M. Stocco Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, USA SY 11-1-2 Zebrafish gonad differentiation and sex determination Bon-chu Chung Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan SY 11-1-3 Enzymes that metabolize sphingosine regulate CYP17 transcription by direct interaction with steroidogenic factor 1 Marion B. Sewer Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA SY 11-1-4 Intracrine regulation of estrogen action by the extragonadal expression of steroidogenic enzymes Matti Poutanen Institute of Biomedicine, University of Turku, Finland

SY15-3 Cushing’s /subclinical Cushing’s syndrome and disease Room 4 Chairpersons: Steven W.J. Lamberts Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Toshihiro Suda Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Aomori, Japan SY 15-3-1 * The medical treatment of Cushing’s disease Steven W. Lamberts Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands SY 15-3-2 Solutions of microsurgical problems in Cushing’s disease at the example of young patients Dieter K. Ludecke Department of Neurosurgery, University of Hamburg, Hamburg, Germany SY 15-3-3 Evaluation of diagnostic tests for ACTH-dependent Cushing’s syndrome Toshihiro Suda Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Aomori, Japan SY 15-3-4 Diagnosis and treatment of subclinical Cushing’s syndrome Mitsuhide Naruse Department of Endocrinology, Metabolism and Hypertension, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

SY15-6 Adrenal development Room 13 Chairpersons: Neil A. Hanley Endocrinology and Diabetes, University of Manchester, UK Ken-ichirou Morohashi Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan SY 15-6-1 * State of the art in adrenal development Neil A. Hanley Endocrinology and Diabetes, University of Manchester, UK SY 15-6-2 Implication of Ad4BP/SF-1 into adrenal development Ken-ichirou Morohashi Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan SY 15-6-3 Shh signaling regulates adrenocortical development and identifies novel progenitors of steroidogenic lineages Ed Laufer Department of Pathology and Cell Biology, Columbia University, New York, USA SY 15-6-4 Molecular pathways in early adrenal and gonad development 27 March Sat. Amanda Swain Institute of Cancer Research, London, UK S730 14th International Congress of Endocrinology

JES-Sponsored Symposia

JES1 Brain sex differentiation and it’s plasticity 9:20-11:00 Room 16 Chairpersons: Yasuo Sakuma Nippon Medical School, Tokyo, Japan Takefumi Kikusui Azabu University, Kanagawa, Japan JES1-1 Sex difference and its plasticity in the expression of aromatase in the medaka brain Kataaki Okubo Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan JES1-2 Social interaction and sex differentiation in anemonefish Eri Iwata Department of Environmental Science, Iwaki Meisei University, Fukushima, Japan JES1-3 Gonadal steroid action on sexual preference in adult rat brain Yasuhiko Kondo Department of Physiology, Nippon Medical School, Tokyo, Japan JES1-4 Sex differences in the human brain, their mechanisms and implications Ivanka Savic-Berglund Department of Neuroscience, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

JES2 Clinical trials in CVEM 14:20-16:00 Room 16 Chairpersons: Juliana C.N. Chan The Chinese University of Hong Kong, Hong Kong Koichi Hayashi Keio University, Tokyo, Japan JES2-1 Incidence of cardiovascular events in hypertensive patients with diabetes and/or obesity: Subanalysis of the CASE-J trial Toshio Ogihara Osaka General Medical Center, Osaka, Japan JES2-2 Atrial natriuretic peptide mediates potent cardiovascular protection: Linkage between endocrinology and cardiology Masafumi Kitakaze Cardiovascular Division of Internal Medicine, National Cardiovascular Center, Suita, Japan JES2-3 Effects of angiotensin-receptor-blockers on the development of new-onset diabetes in hypertensive patients: Meta-analysis of the randomized controlled clinical trials Kenji Ueshima EBM Research Center, Kyoto University Graduate School of Medicine, Japan JES2-4 Reducing cardiovascular risk in type 2 diabetes Juliana C.N. Chan Hong Kong Institute of Diabetes and Obesity, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, NT, Hong Kong

JES3 Epidemiology of diabetes and metabolic syndrome in the world 14:20-16:00 Room 17 Chairpersons: Fahmy E. Amara Emeritus Professor, Alexandria University, Egypt Ariachery C. Ammini Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India JES3-1 Epidemiological aspects of metabolic syndrome and diabetes mellitus in Japanese general population Shigeyuki Saitoh Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan JES3-2 Metabolic syndrome and cardiovascular disease risk in Korean adults: The Korean heart study Sun Ha Jee Department of Epidemiology, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea JES3-3 Epidemic of diabetes and metabolic syndrome in China -The national nutrition and health survey (2002) Guangwei Li Department of Endocrinology, China-Japan Friendship Hospital, China JES3-4 Epidemiology of diabetes and metabolic syndrome in Thailand Wannee Nitiyanant Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand JES3-5 Type 2 diabetes mellitus and the metabolic syndrome in sub-Saharan Africa Augustine E. Ohwovoriole Department of Medicine, College of Medicine, University of Lagos, Nigeria Scientific Program Sat. March 27 S731

Oral Hot Topics 12:10-13:00

OH1 Diabetes mellitus 1 Room 9 OH3 Bone and mineral metabolism Room 11 Chairperson: Hitoshi Ishida Third Department of Internal Medicine, Kyorin University Chairperson: Toshitsugu Sugimoto Shimane University Faculty of Medicine, Japan School of Medicine, Japan OH3-1 OH3-3 OH1-1 OH1-2 OH1-3 OH4 CVEM 1 Room 12 OH2 Thyroid Room 10 Chairperson: Issei Tanaka Hirakata Kohsai Hospital, Japan Chairperson: Yoshiharu Murata Research Institute of Environmental Medicine, Nagoya OH4-1 OH4-2 OH4-3 University, Japan OH2-1 OH2-2 OH2-3

Oral Sessions 9:20-11:00, 11:10-12:00

O 1 Diabetes mellitus 1 11:10-12:00 Room 11 O 5 Pituitary / Neuroendocrinology 1 11:10-12:00 Room 16 Chairperson: Tadahiro Kitamura Gunma University, Japan Chairperson: Naomi Hizuka Department of Medicine II, Tokyo Women’s Medical O 1-1 O 1-2 O 1-3 O 1-4 University, Japan O 5-1 O 5-2 O 5-3 O 5-4 O 2 Diabetes mellitus 2 11:10-12:00 Room 12 Chairperson: Kazuyuki Tobe First Department of Internal of Medicine, University of O 6 CVEM 1 9:20-10:10 Room 17 Toyama, Japan Chairperson: Toshio Nishikimi Dokkyo Medical University, Japan O 2-1 O 2-2 O 2-3 O 2-4 O 6-1 O 6-2 O 6-3 O 6-4 O 3 Thyroid 1 11:10-12:00 Room 13 O 7 CVEM 2 10:10-11:00 Room 17 Chairperson: Shigekazu Sasaki Hamamatsu University School of Medicine, Japan Chairperson: Akira Nishiyama Kagawa University Medical School, Japan O 3-1 O 3-2 O 3-3 O 3-4 O 7-1 O 7-2 O 7-3 O 7-4

O 4 Bone and mineral metabolism 11:10-12:00 Room 14 O 8 Adrenal 1 11:10-12:00 Room 17 Chairperson: Mitsuyasu Itoh Division of Endocrinology and Metabolism, Fujita Health Chairperson: Hiroyuki Sasamura Keio University, Japan University, School of Medicine, Japan O 8-1 O 8-2 O 8-3 O 8-4 O 4-1 O 4-2 O 4-3 O 4-4

Poster Presentations 13:10-14:20 Event Hall 27 March Sat.

P1-1 Diabetes mellitus 1 P1-4 Diabetes mellitus 4 Chairperson: Hidenori Katsuta The Third Department of Internal Medicine, Kyorin Chairperson: Hitomi Imachi Department of Internal Medicine, Division of Endocrinology University, Tokyo, Japan and Metabolism, Faculty of Medicine, Kagawa University, Kagawa, Japan P1-1-1 P1-1-2 P1-1-3 P1-1-4 P1-1-5 P1-1-6 P1-4-1 P1-4-2 P1-4-3 P1-4-4 P1-4-5 P1-4-6 P1-1-7 P1-1-8 P1-4-7 P1-4-8 P1-4-9 P1-2 Diabetes mellitus 2 P1-5 Diabetes mellitus 5 Chairperson: Noriko Satoh-Asahara Division of Diabetic Research, Clinical Research Chairperson: Masakazu Hirata Pharmaceuticals and Medical Devices Agency, Japan Institute, National Hospital Organization Kyoto Medical Center, Japan P1-5-1 P1-5-2 P1-5-3 P1-5-4 P1-5-5 P1-5-6 P1-2-1 P1-2-2 P1-2-3 P1-2-4 P1-2-5 P1-2-6 P1-5-7 P1-5-8 P1-2-7 P1-2-8 P1-6 Diabetes mellitus 6 P1-3 Diabetes mellitus 3 Chairperson: Michio Shimabukuro Second Department of Internal Medicine, Chairperson: Masahiro Yamamoto Internal Medicine 1, Shimane University Faculty University of the Ryukyus, Okinawa, Japan of Medicine, Izumo, Japan P1-6-1 P1-6-2 P1-6-3 P1-6-4 P1-6-5 P1-6-6 P1-3-1 P1-3-2 P1-3-3 P1-3-4 P1-3-5 P1-3-6 P1-6-7 P1-6-8 P1-6-9 P1-3-7 P1-3-8 S732 14th International Congress of Endocrinology

Poster Presentations 13:10-14:20 Event Hall

P1-7 Diabetes mellitus 7 P4-5 Thyroid 5 Chairperson: Kouichi Inukai Division of Endocrinology and Diabetes, Saitama Medical Chairperson: Yuji Hiromatsu Department of Medicine, Division of Endocrinology and University, Saitama, Japan Metabolism, Kurume University School of Medicine, Fukuoka, Japan P1-7-1 P1-7-2 P1-7-3 P1-7-4 P1-7-5 P1-7-6 P4-5-1 P4-5-2 P4-5-3 P4-5-4 P4-5-5 P4-5-6 P1-7-7 P1-7-8 P1-7-9 P4-5-7 P4-5-8 P2-1 Obesity and adiposcience 1 P5-1 Bone and mineral metabolism 1 Chairperson: Jun Hino Department of Biochemistry, National Cardiovascular Center Chairperson: Daisuke Inoue Third Department of Medicine, Teikyo University Chiba Research Institute, Osaka, Japan Medical Center, Chiba, Japan P2-1-1 P2-1-2 P2-1-3 P2-1-4 P2-1-5 P2-1-6 P2-1-7 P2-1-8 P5-1-1 P5-1-2 P5-1-3 P5-1-4 P5-1-5 P5-1-6 P5-1-7 P5-1-8 P2-2 Obesity and adiposcience 2 P5-2 Bone and mineral metabolism 2 Chairperson: Ken-ichi Aihara Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Chairperson: Yasato Komatsu Department of Endocrinology, Kyoto City Hospital, Tokushima, Japan Kyoto, Japan P2-2-1 P2-2-2 P2-2-3 P2-2-4 P2-2-5 P2-2-6 P5-2-1 P5-2-2 P5-2-3 P5-2-4 P5-2-5 P5-2-6 P2-2-7 P2-2-8 P5-2-7 P5-2-8 P2-3 Obesity and adiposcience 3 P5-3 Bone and mineral metabolism 3 Chairperson: Hiroshi Sakaue Department of Nutrition and Metabolism, Institute of Chairperson: Masako Miura Department of Medicine and Clinical Science, Kyoto Health Biosciences, The University of Tokushima, Tokushima, Japan University Graduate School of Medicine, Kyoto, Japan P2-3-1 P2-3-2 P2-3-3 P2-3-4 P2-3-5 P2-3-6 P5-3-1 P5-3-2 P5-3-3 P5-3-4 P5-3-5 P5-3-6 P2-3-7 P5-3-7 P5-3-8 P2-4 Obesity and adiposcience 4 P7-1 Pituitary / Neuroendocrinology 1 Chairperson: Kenji Moriyama Mukogawa Women’s University, Japan Chairperson: Izumi Fukuda Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women’s Medical University, Tokyo, Japan P2-4-1 P2-4-2 P2-4-3 P2-4-4 P2-4-5 P2-4-6 P2-4-7 P2-4-8 P7-1-1 P7-1-2 P7-1-3 P7-1-4 P7-1-5 P7-1-6 P7-1-7 P7-1-8 P2-5 Obesity and adiposcience 5 P7-2 Pituitary / Neuroendocrinology 2 Chairperson: Hajime Ueshiba Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine, Japan Chairperson: Yasuhiko Okimura Department of Biophysics, Kobe University Graduate School of Health Science, Japan P2-5-1 P2-5-2 P2-5-3 P2-5-4 P2-5-5 P2-5-6 P2-5-7 P2-5-8 P7-2-1 P7-2-2 P7-2-3 P7-2-4 P7-2-5 P7-2-6 P7-2-7 P7-2-8 P4-1 Thyroid 1 P7-3 Pituitary / Neuroendocrinology 3 Chairperson: Tsuyoshi Kouki Department of Endocrinology and Metabolism, University of the Ryukyus School of Medicine, Okinawa, Japan Chairperson: Sumiko F. Kato Department of Endocrinology and Metabolism, Kishiwada City Hospital, Japan P4-1-1 P4-1-2 P4-1-3 P4-1-4 P4-1-5 P4-1-6 P4-1-7 P4-1-8 P7-3-1 P7-3-2 P7-3-3 P7-3-4 P7-3-5 P7-3-6 P7-3-7 P7-3-8 P7-3-9 P4-2 Thyroid 2 P7-4 Pituitary / Neuroendocrinology 4 Chairperson: Akira Miyauchi Kuma Hospital, Japan Chairperson: Nobuhiro Miki Department of Medicine II, Institute of Clinical P4-2-1 P4-2-2 P4-2-3 P4-2-4 P4-2-5 P4-2-6 Endocrinology, Tokyo Women’s Medical University, Japan P4-2-7 P4-2-8 P7-4-1 P7-4-2 P7-4-3 P7-4-4 P7-4-5 P7-4-6 P4-3 Thyroid 3 P7-4-7 P7-4-8 P7-4-9 Chairperson: Naotetsu Kanamoto Department of Medicine and Clinical Science, P7-5 Pituitary / Neuroendocrinology 5 Kyoto University Graduate School of Medicine, Kyoto, Japan Chairperson: Hideki Katakami Department of Medicine, Division of Clinical Research P4-3-1 P4-3-2 P4-3-3 P4-3-4 P4-3-5 P4-3-6 Sciences, Teikyo University Chiba Medical Center, Chiba, Japan P4-3-7 P4-3-8 P4-3-9 P7-5-1 P7-5-2 P7-5-3 P7-5-4 P7-5-5 P7-5-6 P4-4 Thyroid 4 P7-5-7 P7-5-8 P7-5-9 Chairperson: Tetsuya Tagami National Hospital Organization Kyoto Medical Center, Kyoto, Japan P4-4-1 P4-4-2 P4-4-3 P4-4-4 P4-4-5 P4-4-6 P4-4-7 P4-4-8 Scientific Program Sat. March 27 S733

Poster Presentations 13:10-14:20 Event Hall

P9-1 CVEM 1 P15-1 Adrenal 1 Chairperson: Koichiro Kuwahara Department of Medicine and Clinical Science, Kyoto Chairperson: Yoshiyu Takeda Internal Medicine, Kanazawa University, Japan Graduate School of Medicine, Kyoto, Japan P15-1-1 P15-1-2 P15-1-3 P15-1-4 P15-1-5 P9-1-1 P9-1-2 P9-1-3 P9-1-4 P9-1-5 P9-1-6 P15-1-6 P15-1-7 P15-1-8 P9-1-7 P9-1-8 P9-1-9 P15-2 Adrenal 2 P9-2 CVEM 2 Chairperson: Kiminori Yamane Department of Molecular and Internal Medicine, Chairperson: Fumitoshi Satoh Nephrology, Endocrinology and Vascular Medicine, Hiroshima University, Japan Tohoku University Hospital, Sendai, Japan P15-2-1 P15-2-2 P15-2-3 P15-2-4 P15-2-5 P9-2-1 P9-2-2 P9-2-3 P9-2-4 P9-2-5 P9-2-6 P15-2-6 P15-2-7 P15-2-8 P9-2-7 P9-2-8 P15-3 Adrenal 3 P9-3 CVEM 3 Chairperson Takamasa Ichijo Department of Internal Medicine, Division of Diabetes Chairperson: Jinya Suzuki The Third Department of Internal Medicine, University of and Endocrinology, Saiseikai Yokohama-city Tobu Hospital, Kanagawa, Japan Fukui, Fukui, Japan P15-3-1 P15-3-2 P15-3-3 P15-3-4 P15-3-5 P9-3-1 P9-3-2 P9-3-3 P9-3-4 P9-3-5 P9-3-6 P15-3-6 P15-3-7 P15-3-8 P15-3-9 P9-3-7 P9-3-8 P9-4 CVEM 4 Chairperson: Shin-ichiro Miura Department of Cardiology, Fukuoka University, Fukuoka, Japan P9-4-1 P9-4-2 P9-4-3 P9-4-4 P9-4-5 P9-4-6 P9-4-7 P9-4-8 P10-1 Tumor 1 Chairperson: Jun-ichi Akahira Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan P10-1-1 P10-1-2 P10-1-3 P10-1-4 P10-1-5 P10-1-6 P10-1-7 P10-1-8 P10-2 Tumor 2 Chairperson: Haruhiro Sato Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan P10-2-1 P10-2-2 P10-2-3 P10-2-4 P10-2-5 P10-2-6 P10-2-7 P11-1 Reproduction and development 1 Chairperson: Sumio Takahashi Department of Integrative Biology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan P11-1-1 P11-1-2 P11-1-3 P11-1-4 P11-1-5 27 March Sat. P11-1-6 P11-1-7 P11-1-8 P11-1-9 P11-2 Reproduction and development 2 Chairperson: Hiroshi Fujiwara Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan P11-2-1 P11-2-2 P11-2-3 P11-2-4 P11-2-5 P11-2-6 P11-2-7 P11-2-8 P11-3 Reproduction and development 3 Chairperson: Hideya Sakakibara Yokohama City University, Japan P13-1-1 P13-1-2 P13-1-3 P13-1-4 P13-1-5 P13-1-6 P13-1-7 P13-1-8 P14-1 Signal transduction 1 Chairperson: Taroh Iiri Department of Endocrinology, The University of Tokyo, Japan P14-1-1 P14-1-2 P14-1-3 P14-1-4 P14-1-5 P14-1-6 P14-1-7 P14-1-8 S734 14th International Congress of Endocrinology

Luncheon Seminars 12:10-13:00

LS1 Metabolic syndrome and RAS inhibition: Mechanistic Insights Room 3 Nippon Boehringer Ingelheim Co., Ltd. / Astellas Pharma Inc. Chairperson: Yoshihiko Saito Nara Medical University, Japan Speaker: Thomas Unger Charité University of Medicine Berlin, Germany LS2 Incretin Biology: Islet and Extrapancreatic Actions of Incretin Hormones Room 4 BANYU PHARMACEUTICAL CO., LTD. Chairperson: Atsunori Kashiwagi Shiga University of Medical Science, Japan Speaker: Daniel J. Drucker Banting and Best Diabetes Centre, University of Toronto, Canada LS3 Role of DPP-4 inhibitor vildagliptin in the protection of islet function Room 5 Novartis Pharma K.K. Chairperson: Yuji Matsuzawa Sumitomo Hospital, Osaka, Japan Speaker: Yasuo Terauchi Department of Endocrinology and Metabolism, Yokohama City University, Yokohama, Japan LS4 Aldosterone synthesis in the brain contributes to hypertension Room 6 Pfizer Japan Inc. Chairperson: Toshio Ogihara Osaka General Medical Center, Osaka Prefectural Hospital Organization / Professor Emeritus, Osaka University, Japan Speaker: Celso E. Gomez-Sanchez The University of Mississippi Medical Center, USA LS5 Heart as an Endocrine Organ Room 7 Takeda Pharmaceutical Company Limited Chairperson: Ryuichi Kikkawa Shiga University of Medical Science, Otsu, Japan Speaker: Michihiro Yoshimura The Jikei University School of Medicine, Tokyo, Japan Hirofumi Yasue Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan

Satellite Symposium 17:50-19:20

SS1 Beta Cells and Blood Glucose: The Pathophysiology and Treatment of Type 2 Diabetes Room 3 Eli Lilly and Company Chairperson: Toshiaki Hanafusa First Department of Internal Medicine, Osaka Medical College, Japan Hiroaki Masuzaki Second Department of Internal Medicine Faculty of Medicine, University of the Ryukyus, Japan Speaker: Christopher J. Nolan Department of Endocrinology, The Canberra Hospital, Medical School, The Australian National University, Australia Geremia Bolli Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy