1-4 of July 2015 in Bordeaux, France

33rd meeting of the European Program Section of ISHR Avec le soutien de ISHR International Society for Heart Research European Section The organizing committee Logistics team

Pierre Dos Santos: LIRYC Institute & CardioThoracic Elza Appatore Research Center of Bordeaux (UMR 1045 Inserm- University of Bordeaux University of Bordeaux) & University Hospital of Bordeaux, Fabrice Blanquie, Deputy head of administration in France charge of communication and institutional life, Security Rodolphe Fischmeister: President-Elect of the ISHR- ES - Signaling and Cardiac Pathophysiology (UMR-S 769 Norbert Loustaunau, Communication Manager, Inserm-University Paris Sud), France Communications Direction, University of Bordeaux David Eisner: President ISHR-ES - Manchester Academic Sandrine Micheneau, Audiovisuel Support Service Health Science Centre, University of Manchester, manager, Audiovisual and Multimedia Service, Logistic Manchester, UK Direction, PILPSE Pôle, University of Bordeaux Peter Ferdinandy: Past-President of ISHR-ES - Céline Thouvenin, Event Manager, Congress & Events Department of pharmacology and pharmacotherapy, Department, University of Bordeaux Semmelweis University, Budapest, Hungary Sophie Vialle, Communication Manager, LIRYC Institute, Derek J Hausenloy: Secretary of the ISHR-ES - The Hatter Bordeaux Cardiovascular Institute, University College of London, UK Jolanda Van der Velden: Treasurer of the ISHR-ES Laboratory for physiology, Institute for cardiovascular research, VU University Medical Center, Amsterdam, Contact Netherlands Thomas Eschenhagen: Department of Experimental Danielle Pichereau-Le Ster, PTIB Manager Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany 33604 Pessac - France Emilio Hirsch: Member of the ISHR-ES Council - [email protected] Department of Molecular Biotechnology and Health +33 (0)5.57.10.28.60 Sciences, Center for Molecular Biotechnology, Torino, Italy Michel Haïssaguerre: LIRYC Institute & CardioThoracic Research Center of Bordeaux (UMR 1045 Inserm- Partners University of Bordeaux) & University Hospital of Bordeaux, France Pierre Jaïs: LIRYC Institute & CardioThoracic Research Center of Bordeaux (UMR 1045 Inserm-University of Bordeaux) & University Hospital of Bordeaux, France Roger Marthan: LIRYC Institute & CardioThoracic Research Center of Bordeaux (UMR 1045 Inserm- University of Bordeaux) & University Hospital of Bordeaux, France Olivier Bernus: LIRYC Institute & CardioThoracic Research Center of Bordeaux (UMR 1045 Inserm-University of ISHR International Society for Heart Research Bordeaux), France European Section Pierre Bordachar: LIRYC Institute & CardioThoracic Research Center of Bordeaux (UMR 1045 Inserm- University of Bordeaux) & University Hospital of Bordeaux, France Philippe Ritter: LIRYC Institute & University Hospital of Bordeaux, France Raymond Roudaut: University of Bordeaux & University

Hospital of Bordeaux, France Avec le soutien de : Cardiovascular adaptation to Ischemia (UMR 1024 Inserm-University of Bordeaux) & University Hospital of Bordeaux, France Cécile Duplàa: Cardiovascular adaptation to Ischemia (UMR 1024 Inserm-University of Bordeaux), France Pascale Dufourcq: Cardiovascular adaptation to Ischemia (UMR 1024 Inserm-University of Bordeaux), France Photo credit Alain-Pierre Gadeau: Cardiovascular adaptation to © Mairie de Bordeaux - Thomas Sanson - Château Olivier - Château Ischemia (UMR 1024 Inserm-University of Bordeaux), Pichon-Longueville France Welcome to Bordeaux, World Capital of Wine

The 33rd Annual Meeting of the European Section of the ISHR will be held in Bordeaux from the 1st until the 4th of July 2015. It will be hosted by the University of Bordeaux (http://www.u-bordeaux.com). The University researchers and 110 research units. It contains several major national research centres including various laboratories of major national centres (CNRS, INSERM, INRA, INRIA, IFREMER, etc.). Ranked among the top universities in France, the

internationally recognized site. carried out all over the world.

You will be received by the teams of the Liryc institute (http://www.ihu-liryc.fr), a multidisciplinary research, clinical practice and training institute that is dedicated to understand electrical malfunctions of the heart. This

We have no doubt you will enjoy your stay in Bordeaux, the world capital of wine. 10,000 new inhabitants arrive science, we hope you will take the opportunity to stroll through the streets of Bordeaux and appreciate its sights, restaurants and cafes.

Rodolphe Fischmeister Pierre Dos Santos President-Elect of the ISHR-ES

A world-renowned destination for its prestigious vineyards, Bordeaux is a beautiful city in an outstanding region, with a habit of surprising its visitors … attractive metropolis. The wine-growing activities and the strong political and cultural links with the British Isles General information

Registration (Prices include taxes) Registration to participate at ISHR can only be done by internet at ishr2015.com.

Registration fee to the Congress Until 9th May 2015 From the 10th May 2015 ISHR non member 400€ 500€ ISHR member 300€ 400€ Students 100€ 150€

breaks, the lunches and the Gala dinner. Registration fee for the social Program: 30€ ; 45€ for companions and 10€ for students.

Registration conditions and cancellation Each registration will only be valid after the reception of payment. The closure date for on-line registration is 29th May 2015. After that, registration can be done on site at the Congress with an increase of 15%. Any cancellation must be done absolutely in writing (letter or fax) to Madame Danielle Pichereau Le Ster - Before 29th May 2015, the Registration will be reimbursed minus 60€ Administration fee (30€ for Students). After this deadline, it will not be possible to get any reimbursement.

Accommodation

Internet site Up to date program, information, registration, submission of abstracts is avalaible on line on the website ishr2015.com

Congress venue Place de la Victoire 33000 Bordeaux

Public transport Tram: Line B - Victoire stop Bus: Line 11 - 16 - 43 - 45 - Victoire stop

Meeting venue 8:30-12:00 ISHR International Council Salle TD5 1 July, Wednesday 12:00 Poster Display 14:00-14:15 Opening ceremony 14:15-15:15 Plenary session 1 - Outstanding Investigator Award lecture microRNAs and the heart: what comes next? Thomas Thum (Hannover, Germany) Chair: Asa Gustafsson (San Diego, USA) - Co-chair: Jolanda Van der Velden (Amsterdam, The Netherlands)

15:30-17:00 Session 1 - Emerging Ca2+ channels in cardiovascular Jonathan Lederer (Baltimore, MD, USA), system Marie Demion (Montpellier, France) st

Stim 1 and Orai in cardiac hypertrophy Jean-Sébastien Hulot (Paris, France) 2015 Donald Bers (Davis, USA) TRPC channels in cardiac physiopathology Jessica Sabourin (Châtenay-Malabry, France) Hind Mehel (Paris, France) culture Catherine Pavoine (Paris, France) Compensated Cardiac HyPERTROPHY Session 2 - Myocardial protection by remote ischemic pre-conditioning Pierre Dos Santos (Bordeaux, France) Clinical application of RIPC Hans Erik Bøtker (Aarhus, Denmark) Cofounders of cardioprotection by RIPC Petra Kleinbongard (Essen, Germany) Circulating nitrite during cardioprotection by RIPC Tienush Rassaf (Düsseldorf, Germany) Overexpression of the mitochondrial Ca2+ uniporter Marika Campesan (Padova, Italy) increases cardiac tolerance against ischemia/reperfusion injury. Zoltan Giricz (Budapest, Hungary) Session 3 - Pathophysiology of heart failure with preserved Jolanda van der Velden (Amsterdam, The ejection fraction Netherlands), Richard L. Moss (Madison, WI, USA) The road to understanding diastolic dysfunction in heart Nazha Hamdani (Amsterdam, The Netherlands) failure with preserved ejection fraction fraction: Novel regulatory mechanisms and therapeutic Wolfgang Linke (Münster, Germany) implications Collagen network Javier Diez (Pamplona, Spain) Altered phosphorylation of cardiac myosin binding protein is a Sumit Kar (Madison, WI, USA) dominant determinant of diastolic function C in hypertrophic cardiomyopathy Monoamine oxidases contribute to oxidative stress and cardi- Nina Kaludercic (Padova, Italy) ac dysfunction in type 1 diabetic hearts 17:00-18:00 18:00-19:30 Session 4 - Calcium induced arrhythmias David Eisner (Manchester, UK) Donald M. Bers (Davis, USA) Ernst Niggli ( Bern, Switzerland) Calcium handling in catecholaminergic polymorphic Ana Maria Gomez (Châtenay-Malabry, France) ventricular tachycardia Role of ryanodone receptor inhibitors in the treatment of Luigi Venetucci (Manchester, UK) catecholaminergic polymorphic ventricular tachycardia Fabien Brette (Bordeaux, France) Phosphorylation of inhibitor-1 at Ser-67 reduces PKA- Davor Pavlovic (Birmingham, UK) mediated stimulation of Na/K ATPase via phospholemman and leads to increased intracellular Na+ in cardiac myocytes. Peter Ferdinandy (Budapest, Hungary), injury revisited

2015 France) st Reducing I/R injury - experimental hope or clinical reality? Fatih Arslan (Utrecht, The Netherlands) Robin P. Choudhury (Oxford, UK) reperfusion using targeted microparticles Monocytes and heart function after acute myocardial infarction Ziad Mallat (Paris, France & Cambridge, UK) Infarct limitation by GYY4137 at reperfusion, a slow-releasing dependency on endothelial NO in the rat in vivo TLR4 expression is associated with left ventricular dysfunction Edith Hochhauser (Petah Tikva, Israel)

Wednesday July, 1 in patients undergoing coronary artery bypass surgery Session 6 - Novel aspects of cell death and survival Metin Avkiran (London, UK), mechanisms in heart failure Lucie Carrier (Hambourg, Germany) Autophagy, mitochondria and heart failure Asa Gustafsson (San Diego, CA, USA) Interplay between UPS and autophagy in the development of Tania Zaglia (Padova, Italy) cardiomyopathies Novel cAMP signalling in cardiac autophagy and apoptosis Frank Lezoualc’h (Toulouse, France) during myocardial stress Alessandra Ghigo (Torino, Italy) chemotherapy-induced cardiomyopathy by promoting cardiac autophagy Derailment of Cellular Protein Quality Control system Vaishali Kakkar (Amsterdam, The Netherlands) represents a contributing factor for muscle atrophy in striated muscle myopathies

Amphitheatre Broca Amphitheatre Durkeim Amphitheatre E 7:30-9:30 ISHR-ES Council Salle du Conseil 08:30 Poster Display Cour d‘honneur 09:00-10:00 Plenary session 2 - Peter Harris Distinguished Scientists Award Cell-Based Therapies for Ischemic Cardiomyopathy - Roberto Bolli (Louisville, KY, USA) Chair: Masatsugu Hori (Osaka, Japan) - Co-chair: Peter Ferdinandy (Budapest, Hungary) 9:30-11:30 JMCC AE Salle du Conseil 10:00-10:30 Atrium & Cour d’honneur 10:30-12:00 Session 7 - Electrophysiological and structural Michel Haïssaguerre (Bordeaux, France), determinants of driver mechanisms in persistent AF: insights from experimental models Jérôme Kalifa (Ann Arbor, MI, USA) Stéphane Hatem (Paris, France) Epi-endocardial dissociation in persistent AF Ulrich Schotten (Maastricht, The Netherlands) 2 July, Thursday Atrial remodeling in conscious freely-moving rats exposed to Yoram Etzion (Beer-Sheva, Israel) sustained atrial tachypacing Inhibition of ER stress-induced autophagy preserves Marit Wiersma (Groningen, The Nether- proteostasis and protects against cardiomyocyte dysfunction lands) in experimental and human Atrial Fibrillation

Fauconnier (Montpellier, France) nd Mitofusin functioning other than mitochondrial fusion Gerald W. Dorn (St Louis, MO, USA) 2015 Oxidation of Opa1 participates in heart ischemic reperfusion Luca Scorrano (Padova, Italy) injury Arnaud Mourier (Köln, Germany) levels in heart Dual knockout of the mitochondrial fusion proteins Mfn1 and Andrew Hall (London, UK) against ischemia-reperfusion injury. Overexpression of mitofusin 2 in the diabetic heart; pathological or cardioprotective remodelling? Session 9 - Extreme adrenergic stress and the heart - Yoshihiko Saito (Nara, Japan), Alexander Lyon (London, UK) Myocardial responses to supraphysiological catecholamine Sian E. Harding (London, UK) stimulation Altered myocardial lipid metabolism after severe adrenergic Elmir Omerovic (, Sweden) Michael J. Shattock (London, UK) trigger for sudden death? Trusha Mistry (London, England, UK) stimulation Prolonged exhaustive exercise induces diastolic dysfunction Olivier Cazorla (Montpellier, France) with preserved systolic function mediated by oxidative stress. 12:00-12:45 Generally Assembly of ISHR-ES 12:00-13:30 Lunch and Posters Atrium & Cour d’honneur

Amphitheatre Broca Amphitheatre Durkeim Amphitheatre E Thursday July, 2nd 2015 Masatsugu Hori (Osaka, Japan), Jane-Lise Samuel (Paris, France) Bertrand Crozatier (Châtenay Malabry, France) Karin Y. van Spaendonck-Zwart (Amsterdam, The Netherlands) Ilse Bollen (Amsterdam, The Netherlands) Atrium & Cour d’honneur Jean-Jacques Schott (Nantes, France) Jean-Jacques (Cambridge, UK) Andrew Grace (Haifa, Israel) Oren Caspi Germany) Frederik Flenner (Hamburg, France) Malorie Blancard (Paris, France) Pierre Dos Santos (Bordeaux, Rainer Schulz (Germany) Marisol Ruiz-Meana (, Spain) Torsten Doenst (Jena, Germany) Siavash Beikoghli Kalkhoran (London, UK) Gabor Koncsos (Budapest, Hungary) France) (Paris, Guicheney Pascale - - vs vs vs Peripartum Cardiomyopathy and Dilated Cardiomyopathy: Peripartum Cardiomyopathy and Dilated Are pregnancy and exercise-induced ventricular hypertrophies hypertrophies ventricular exercise-induced and pregnancy Are really physiological? Pregnancy unmasks genetic cardiomyopathies Subsarcolemmal hypertrophy and heart failure de pointes Subsarcolemmal protein content and function Targeted arrhytmia management Targeted arrhytmia iPS syndromes with inherited arrhythmogenic Modeling incidence in ventricular cells and muscle Increased arrhythmia a mouse model of hypertrophic cardio strip preparations of myopathy Inherited Cardiac Arrhythmias in the Era of Next Generation in the Era of Next Cardiac Arrhythmias Inherited with junctional sarcoplasmic reticulum in MFN2-KO mice using with junctional sarcoplasmic reticulum a 3 dimensional approach contributes to de Elevated mitochondrial oxidative stress creased heart function in prediabetes stress model Session 12 - Pregnancy as a cardiac Session 11 - Subsarcolemmal - 11 Session location! Location, location, Session 10 - Genetics of cardiac arrhythmias cardiac of 10 - Genetics Session

15:00-16:30 13:30-15:00 13:30-15:00

Thursday July, 2 July, Thursday 2015 nd 16:30-18:00 Session 13 - New Insights into the mechanisms of Olivier Bernus (Bordeaux, France) The Importance of Purkinje Activation in Long Duration Raymond E. Ideker (Birmingham, Alabama, Ventricular Fibrillation USA) Bruno Stuyvers (Bordeaux, France) designed to preserve the electric conduction in the heart? Reconstructing transmural electrical activity from intact Richard Walton (Bordeaux, France) tisssue using novel optical mapping approaches Session 14 - Mitochondrial Ca transport & cardiac diseases Hossein Ardehali (Chicago, USA), Mitochondrial oxydative stress and arrhythmias in hypertrophic Christoph Maack (Hamburg, Germany)

cardiomyopathy 2 July, Thursday Calcium Regulation of Mitochondrial Function Elizabeth Murphy (Columbia, MD, USA) Endoplasmic reticulum, Ca2+ and mitochondria Michel Ovize (Lyon, France) Measuring the Mitochondrial Membrane Potential In Vivo Victoria Pell (Cambridge, UK) Using Mitochondria-Targeted Click Chemistry - Soni Deshwal (Padova, Italy) tive stress through monoamine oxidases Session 15 - Heart repair with pluripotent stem cells Keiichi Fukuda (, Japan), nd

Michel Puceat (Marseille, France) 2015 Clinical translation of pluripotent stem cell-based heart repair Stefan Janssens (Leuven, Belgium) Stem Cell Allogenicity for Cardiac repair and Beyond Reem Al-Daccak (Paris, France) Translating engineered heart muscle-based heart failure repair Wolfram H. Zimmermann (Göttingen, Germany) Anna Hnatiuk (BA, Argentina) function in an ovine model of acute myocardial infarction NO donor-induced cytoprotection against simulated ischemia/ Aniko Görbe (Szeged, Hungary) reperfusion induced cell death in induced pluripotent stem cell-derived cardiac myocytes 18:00-19:30 Plenary session 3 Presentation of ISHR-ES Medal of Merit to Fabio di Lisa (Bologna, Italy) Award Servier Modulation of the Notch signaling pathway by ErbB2: role in the cardiotoxicity of ErbB2- targeted therapy - Pietro Ameri (Genova, Italy) Presentation of “Distinguished Leader Award” to David Hearse (London, UK) Novartis Chair: Metin Avkiran (London, UK) - Co-chair: Richard L. Moss (Madison, WI, USA) From 20:30 Gala Dinner at the CAPC

Amphitheatre Broca Amphitheatre Durkeim Amphitheatre E Friday July, 3rd 2015 12:00-13:30 10:30-12:00 10:00-10:30 09:00-10:00 8:30-9:00 and cardiacfunction edema intersticial permeability, Myocardial - 18 Session Lunch andPosters Session 16-Metabolicsignalingpathways Poster Display really myfriend? Session 17-Heartandcancer:Istheenemyofmy Ischemic postconditioningpreventsischemia-inducedacute Myocardial edema:Atranslationalview Extracellular matrixdrivesvesselnavigation anthracycline-induced cardiotoxicityinvitroandvivo perfused rathearts Real-time opticalmappingofacutemitochondrialdysfunction inhibition Two birdswithonestone:blockingdoxorubicin-induced of cardioprotection mechanisms the to understading in advances Recent transport incardiomyocytes A roleforFocalAdhesionKinaseinthestimulationofglucose infarction relevant, closed-chestpigmodelofacutemyocardial myocardial dilationandlimitscardiacedemainaclinically treatment Role ofEpacsignalingincardiotoxicityinducedbyanticancer- Role ofP2Y4receptorinadipogenesisandcardioprotection. Cardiac IronHomeostasisandFunction The CardiacHepcidin/FerroportinAxisisImportantfor metabolism Adiponectin inheartfailure,focusonskeletalmuscle Sirtuin 1andenergymetabolisminnormalfailingheart various heartdiseases against strategies therapeutic for target multifaceted a AMPK, Chair: DavidEisner(Manchester,USA)-Co-chair:PierreDosSantos(Bordeaux,France) Plenary session4-PeterHarrisDistinguishedScientistsAward X-ROS signalinginHeart- Jon Lederer(Maryland,USA) Republic) Czech Králové, (Hradec Sterba Martin Eric Morel( (Châtenay-Malabry, France) David Lefer(Atlanta,USA),EricMorel Anne lemaire(Bruxelles,Belgique) (Antwerp, Samira Lakhal-Littleton(Oxford,UK) Berendoncks Van Belgium) M. (Châtenay-Malabry, An Garnier France) Anne Luc Bertrand(Louvain,Belgium) Fabio DiLisa(Padova,Italy) Derek JHausenloy(London,UK), Atrium&Courd’honneur Cour d’honneur Atrium &Courd’honneur land) Christophe Montessuit(Geneva,Switzer Tamas Baranyai(Budapest,Hungary) David Garcia-Dorado(Barcelona,Spain) Arkadi Rutkovskiy(Oslo,Norway) Frederico Bussolino(Torino,Italy) France) Alain Lacampagne(Montpellier, Republic) Hana Jansova(HradecKrálové,Czech Maeve Elder(London,UK) Emilio Hirsch(Torino,Italy) Châtenay-Malabry, France honneur ) - 13:30-15:00 Session 19 - Compartmentation of cardiac signaling Lea M. Delbridge (Melbourne, Australia), Rodolphe Fischmeister (Châtenay-Malabry, France) A-kinase anchoring proteins: molecular regulators of cardiac Dario Diviani (Lausanne, Switzerland) remodeling Viacheslav O. Nikolaev (Hamburg, cardiomyocytes Germany) Cyclic nucleotide signaling compartmentation in normal and Grégoire Vandecasteele (Châtenay failing heart Malabry, France) - lands) HCM mouse model Cyclic GMP-mediated phosphorylation of titin reduces passive Selene J. Sollie (Oslo, Norway) tension in rat cardiomyocytes Session 20 - Imaging the heart from within Gemma Vilahur (Barcelona, Spain), Sean M Davidson (London, UK) Superresolution meets physiology: EC coupling super-hubs in Stephan E. Lehnart (Göttingen, atria Germany) Fluorescence imaging of cardiac mitochondria in ischaemia Sean M Davidson (London, UK) and reperfusion Multimodality imaging of the adult murine heart Daniel J. Stuckey (London, UK) Nanoscale changes in ryanodine receptor organisation JPH2 Christian Soeller (Auckland, NZ) transgenic mice A new experimental model for magnetic resonance Fanny Vaillant (Bordeaux, France) investigations of an isolated working heart from a large animal Session 21 - Joint SASCAR-ISHR-ES Session - Cardiovascular Thomas Eschenhagen (Hamburg, biomaterials and regenerative medicine Germany), Sandrine Lecour (Cape Friday July, 3 July, Friday Town, South Africa) Injectable biomaterials therapy for heart failure Neil H. Davies (Cape Town, South Africa) The fascinating journey of stem cell therapy for heart disease Massimiliano Gnecchi (Pavia, Italy) Engineered heart tissues for cardiac repair Thomas Eschenhagen (Hamburg, Germany) In vivo implantation of mesenchymal stem cells-tissue Megan Swim (Bristol, UK) engineered grafts fail to produce blood vessel-like structure rd 2015 Katarina Zihlavnikova (Oslo, Norway) 15:45 Social event & Dinner, at Château Giscours

Amphitheater Broca Amphitheater Durkeim Amphitheater E Saturday July, 4th 2015 honneur Joseph M. Metzger (Minneapolis, MN, USA) Diederik W. D. Kuster (Maywood, IL, USA) Ilse Bollen (Amsterdam, The Netherlands) Manual Mayr (London, UK), Joost P. G. Sluijter (Utrecht, The Netherlands) Jean-Luc Balligand (Brussels, Belgium) Serena Zacchigna (Trieste, Italy) Eva van Rooij (Utrecht, The Netherlands) Marie Cauquil (Toulouse, France) Sarah Pedretti (Geneva, Switzerland) Atrium & Cour d’honneur Atrium & Cour d’honneur Italy), Emilio Hirsch (Torino, Norway) Finn Olav Levy (Oslo, Germany) Lucie Carrier (Hamburg, Germany) Olympia Bikou (Heidelberg, UK) Alexander Lyon (London, Germany) Giulia Mearini (Hamburg, Mathieu Pernot (Pessac, France) (Châtenay-Malabry, France) Jolanda van der Velden (Amsterdam, The Netherlands) Zoltan Papp (Debrecen, Hungary) Cour d’honneur Cour Chair: Elisabeth Murphy (Columbia, MD, USA) - MD, USA) Murphy (Columbia, Chair: Elisabeth Plenary session 5 - President’s Distinguished Lecture Distinguished 5 - President’s session Plenary

Co-chair: Rodolphe Fischmeister (Châtenay-Malabry, France) (Châtenay-Malabry, Rodolphe Fischmeister Co-chair: A central role of MG53 in metabolic syndrome and diabetic cardiomyopathy - and diabetic cardiomyopathy syndrome role of MG53 in metabolic A central microRNAs in cardiac regeneration Regulation of nuclear ephrin-B1 in cardiomyocytes: impact on heart regeneration HDL-induced cardioprotection against ischemia reperfusion involves miRNAs Dnmt3a downregulation by miR29a promotes adult cardiac in infarcted hearts Myocyte proliferation by microRNAs to enhance cardiac repair highly prevalent 25 bp deletion mutation in MYBPC3 highly prevalent 25 bp deletion mutation A mutation in the glutamate-rich region dilated of cardiomyopathy RBM20 through causes missplicing impaired Frank-Starling mechanism of titin and Sarcomere active drugs in heart failure Troponin I residues as molecular myocyte performance determinants of cardiac In vivo pathophysiology of hypertrophic cardiomyopathy in a development of dilated cardiomyopathies contraction cardiac of cost energetic and mutations Sarcomere Gene therapy for arrhythmia control Gene therapy for arrhythmia failure Gene therapy in heart gene therapy in juvenile Mybpc3- Evaluation of Mybpc3 targeted knock-in mice Gene therapy for hypertrophic cardiomyopathy Gene therapy for hypertrophic Lunch and Posters heart Session 24 - MicroRNAs for regenerative therapy of the Session 23 - Control of cardiac performance by sarcomere by performance cardiac of Control - 23 Session proteins therapy of cardiac diseases Session 22 - Gene Poster Display Poster

12:00-13:30 10:00-10:30 10:30-12:00 09:00-10:00 8:30-9:00

Saturday July, 4 July, Saturday 2015 th 13:30-15:00 Session 25 - Epigenetic control of cardiac remodeling Federica del Monte (Boston, MA, USA), Anne Garnier (Châtenay-Malabry, France) Histone deacetylase signaling in cardioprotection Joahnnes Backs (Heidelberg, Germany) Roberto Papait (Rozzano, Italy) cardiac hypertrophy Epigenetics and noncoding RNAs in heart failure Leon de Windt (Maastricht, The Netherlands) Aude Angelini (Paris, France) integrity and protects against oxidative stress in SRF-related dilated cardiomyopathy - Kate L. Weeks (London, UK) sessment of protein nucleo-cytoplasmic shuttling in live adult cardiomyocytes pathophysiology France), Jean-François Arnal (Toulouse, France) Jane-Lyse Samuel (Paris, France) Vera Regitz-Zagrosek (Berlin, Germany) implications to pharmacotherapy Susan E. Howlett (Halifax, Canada) Attila Olah (Budapest, Hungary) of exercise-induced left ventricular hypertrophy in a rat model Igor Khaliulin (Bristol, UK) System to Remote Ischaemic Preconditionning in Young Healthy Subjects Session 27 - Circadian rhythms in cardiac repair: new Rui-Tai Hui (, China), Manuel mechanisms for an old phenomenon Galiñanes (Barcelona, Spain) Circadian rhythms in cardiac regeneration: experimental basis Linda W. van Laake (Utrecht, The Netherlands) for a clinical phenomenon Mesp1 controls the speed and polarity of cardiovascular pro- Giuseppe Chiapparo (Bruxelles, Belgium) genitor migration Angiogenesis is regulated by the circadian clock Yihai cao (Stockholm, Sweden) Ephrin-B1 blocks adult cardiomyocyte proliferation and cardi- Céline Mias (Toulouse, France) ac tissue regeneration Endothelial progenitor cells, VEGF and cytokines in patients Ka Khmelnitskaya (Saint-Petersburg, Russian Federation) chronic heart failure 15:00-16:00 Plenary session 6 - Posters award ceremony Closing session

Amphitheatre Broca Saturday July, 4 Amphitheatre Durkeim Amphitheatre E th 2015 Gala Dinner & Social Event Information

On Thursday, a Gala dinner will be held at the CAPC has now become the Contemporary Art Museum of Bordeaux, a beautiful place, down town by the Garonne river.

To get there from the conference site, with the tram line B: Place Victoire stop CAPC stop

On Friday, we will host a social event at Château Giscours

Departure at 3:45PM, from Place de la Victoire Departure from Giscours at 9:30PM

Photo credit: ©CAPC Bordeaux - ©Château Giscours