This is a repository copy of Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer? . White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/1045/ Article: Clough, G.R., Truscott, J. and Haigh, L.I.G. (2004) Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer? Breast Cancer Research, 6 (Suppl ). p. 18. ISSN 1465-542X https://doi.org/10.1186/bcr837 Reuse See Attached Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing
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[email protected] https://eprints.whiterose.ac.uk/ Available online http://breast-cancer-research.com/supplements/6/S1 Abstracts from Symposium Mammographicum 2004 Edinburgh International Conference Centre, 19–20 July 2004 1 Developing new treatments for breast cancer D Lane University of Dundee, UK and Cyclacel Ltd, UK Breast Cancer Res 2004, 6(Suppl 1):P1 (DOI 10.1186/bcr820) Twenty-five years after its first description the p53 protein has A key regulator is Mdm2, an E3 ubiquitin ligase, that binds and been shown to play a key role in both cancer and ageing. The p53 ubiquitinates p53 and directs its degradation via the proteosome. protein is activated by many different stress pathways, including Small potent peptides that can block the p53 Mdm2 interaction oncogene action and DNA damage. The elucidation of the p53 and activate the p53 response have been described.